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<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WSL2</accession>
    <name>A0A103WSL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_025526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol polyphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006495">
        <property type="protein sequence ID" value="KVH77699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WSL2"/>
    <dbReference type="STRING" id="59895.A0A103WSL2"/>
    <dbReference type="Gramene" id="KVH77699">
        <property type="protein sequence ID" value="KVH77699"/>
        <property type="gene ID" value="Ccrd_025526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045849">
        <property type="entry name" value="IP5P_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666:SF5">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH77699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="18858" checksum="2F187D72FCFF1781" modified="2016-04-13" version="1">MTRSEGEEEIHPFNEESNFDELMDGPADLNVNMSMKTSDSNDNLLASMQAKGDLERRLSSPKRLDRASLAMTVLFHTRLEYLLWALGRPYWVHKLFREVCVYKKRKANVEGSSMFRIIRLGDLNYRLNSLYDGARELISKNDWPKLLECDQLMRELRKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBF4</accession>
    <name>A0A103XBF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Helicase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_025082</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005994">
        <property type="protein sequence ID" value="KVH87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XBF4"/>
    <dbReference type="Gramene" id="KVH87633">
        <property type="protein sequence ID" value="KVH87633"/>
        <property type="gene ID" value="Ccrd_025082"/>
    </dbReference>
    <dbReference type="OMA" id="ICPIANC"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080188">
        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000068">
        <property type="entry name" value="SNF2 domain-containing protein / helicase domain-containing protein / zinc finger protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000071">
        <property type="entry name" value="SNF2 domain-containing protein / helicase domain-containing protein / zinc finger protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="604"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1036"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1183"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH87633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1346" mass="147917" checksum="213F1BD930201DE4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBW3</accession>
    <name>A0A103XBW3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01005777">
        <property type="protein sequence ID" value="KVH87841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBW3"/>
    <dbReference type="STRING" id="59895.A0A103XBW3"/>
    <dbReference type="Gramene" id="KVH87841">
        <property type="protein sequence ID" value="KVH87841"/>
        <property type="gene ID" value="Ccrd_024847"/>
    </dbReference>
    <dbReference type="OMA" id="TAEYHIY"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000052">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF57">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="74"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="448" mass="48990" checksum="DDED7C5FF1386DDF" modified="2016-04-13" version="1">MENVDKLEMNSSAADRRLSTLARHLAVTINNEGSSIFSSPTSAGDSAFANVARAPEDPILGVTVAYNKDPSPVKLNLGVGAYRTEEGKPLVLNVVRKAEQLLVNDRSRVKEYLPIVGLADFNKLSAKLILGADSPAIHGNLVTTVQCLSGTGSLRVGAEFLARHYRERTIYIPNPTWGNHTKVFTLAGLTVKTYRYYDPVTRGLNIQGLLEDLESAPTGAIVLLHACAHNPTGVDPTLQQWEQIRQMIRSKSLLPFFDSAYQGFASGSLDGDAQSVRMFVGDGGECFIAQSYAKNMGLYGERVGALSIVCRTADVASRVNSQLKLVIRPMYSNPPIHGASIVATILKDRNLYHEWTLELKAMADRIITMRKHLFDALGARGTPGDWSHIIKQIGMFTFTGLNRKQVTFMTKEYHIYMTSDGRISMAGLSSRTVPHLADAIHAAVTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC45</accession>
    <name>A0A103XC45_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine permeases (TC 2.A.7.14) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005644">
        <property type="protein sequence ID" value="KVH87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC45"/>
    <dbReference type="STRING" id="59895.A0A103XC45"/>
    <dbReference type="Gramene" id="KVH87992">
        <property type="protein sequence ID" value="KVH87992"/>
        <property type="gene ID" value="Ccrd_024626"/>
    </dbReference>
    <dbReference type="OMA" id="LGPKAYW"/>
    <dbReference type="OrthoDB" id="683622at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015211">
        <property type="term" value="F:purine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030182">
        <property type="entry name" value="PUP_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376">
        <property type="entry name" value="OS09G0467300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376:SF3">
        <property type="entry name" value="PURINE PERMEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16913">
        <property type="entry name" value="PUNUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="42434" checksum="DC87160645ACAC56" modified="2016-04-13" version="1">MSNSSQSTSPKKVRFQHPEINWLTSNKSSLYGKPYKILVTLNYICLFVGSVSSSLLLKFYFNHKGSNLWLSTWVQSAGFPLLLLPIYLPYHLHCFRPKEANKRRKPFSSFDIKLLSLSFGVGLMLGVSNLCFSWGSSYLPLSTWSLVLSSQLAFTLLLSILIVKQKITFLNVNCVILLTLGCVLLAMNSSGDRPEGLTREKYLIGFLTTVCAGLLFALYLPLMEKIYRKVDCYAMVMEMQFLMELTATALATAGMAVAGGFKEMRHESDEVFDLGPTRYWLTVGFNVVTWQLSFMGAAGMVFLTTSLTGGICMTALMAMNVLGGVVVYGDDFKGPKVVSTVLCLWGFCSYVYGMYVKMKDDNNGGDRDDENQAAAAATIDGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDD9</accession>
    <name>A0A103XDD9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_026162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005352">
        <property type="protein sequence ID" value="KVH88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDD9"/>
    <dbReference type="STRING" id="59895.A0A103XDD9"/>
    <dbReference type="Gramene" id="KVH88678">
        <property type="protein sequence ID" value="KVH88678"/>
        <property type="gene ID" value="Ccrd_026162"/>
    </dbReference>
    <dbReference type="OMA" id="VTCGKTM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="577" mass="64050" checksum="FF718A7A05A2FBC1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE02</accession>
    <name>A0A103XE02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_024741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005326">
        <property type="protein sequence ID" value="KVH88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE02"/>
    <dbReference type="STRING" id="59895.A0A103XE02"/>
    <dbReference type="Gramene" id="KVH88919">
        <property type="protein sequence ID" value="KVH88919"/>
        <property type="gene ID" value="Ccrd_024741"/>
    </dbReference>
    <dbReference type="OMA" id="ANMGYWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008191660" description="Dirigent protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="38444" checksum="5E46EF08F84FBF38" modified="2016-04-13" version="1">MAQTLPILTILLLSLLLQTQSHKFSSKLSPKSFGFKKEKLSHLHFYFHDIVGGDHPTAVRVAAAATTNTSQTGFGATVMIDDPLTVGPERTSKIVGRAQGIYASACLTETRLLMALNYVFVEGKYNGSTLSILGTNSVMSPVREMPIVGGSGLFRFARGYALAKTVFFNISNGKYNGSSLSILGRNAVLDPMREMTVVGGSGLFLFAKGYAQAKTHSLDLETGNAVVEYNVVAEATVTNTSASLFGAVVMIDDPLTVGPERTSRIVGRAQGLYASADLDEFGLTMVLNYVFIEGKYNGSTLSILGRNKVMSSVREMPIIGGTGLFRFARGYALAKTYSLNFSNGDAVVEYNVYVIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEF5</accession>
    <name>A0A103XEF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_008791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005288">
        <property type="protein sequence ID" value="KVH89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XEF5"/>
    <dbReference type="Gramene" id="KVH89222">
        <property type="protein sequence ID" value="KVH89222"/>
        <property type="gene ID" value="Ccrd_008791"/>
    </dbReference>
    <dbReference type="OMA" id="KMGFEHD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF486">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="807"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="898" mass="99670" checksum="742BA799E0240A6A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF48</accession>
    <name>A0A103XF48_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">riboflavin kinase</fullName>
            <ecNumber evidence="2">2.7.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005196">
        <property type="protein sequence ID" value="KVH89608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF48"/>
    <dbReference type="STRING" id="59895.A0A103XF48"/>
    <dbReference type="Gramene" id="KVH89608">
        <property type="protein sequence ID" value="KVH89608"/>
        <property type="gene ID" value="Ccrd_008425"/>
    </dbReference>
    <dbReference type="OMA" id="QWDGRES"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000119">
        <property type="entry name" value="Bifunctional riboflavin kinase/FMN phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="8">
        <location>
            <begin position="268"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="42969" checksum="37349537A588B41F" modified="2016-04-13" version="1">MQQNCVVHSSFLSICVVVSVRRRELRLPKFVNASLKSSARVLVLTKWMMNSVRKLVSCVILDLDGTLVNTDGIVCEVLKAYLVKYEKKWDGREAHKIIGKTPIEAAAAIVEDYGLPLSKEDLLSEISPMFSDQWCKLKALPGAYRLITHLRGHGVQMALASNSPRASIETKISYHPTWKESFSAIIAGDEVKSGKPSPEIFLEAAKRLSIDPSKCLVIEDSLPGITAAKAAEMEVVAVPSQPKQSHLYTAADEVINSLLDLRPENWEPWHIGGPVIKGYGRGSKVLGIPTANLSVEGYATVLAEHPAGVYFGWAKLSNRGVYKMVMSLGWNPYFNNTEKTIANFPSLESLVAKIHEDGKIAENALELPSYAKYKDEKYFTSIAIGEDGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG91</accession>
    <name>A0A103XG91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG91"/>
    <dbReference type="STRING" id="59895.A0A103XG91"/>
    <dbReference type="Gramene" id="KVH90208">
        <property type="protein sequence ID" value="KVH90208"/>
        <property type="gene ID" value="Ccrd_007795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37195:SF2">
        <property type="entry name" value="NUCLEOLIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37195">
        <property type="entry name" value="OS01G0332900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="15078" checksum="F7B64D84A4D823E9" modified="2016-04-13" version="1">MAESAADALGHINLENEVGADTDELNMPLTTPSNGASASSIPQDVEASSKKRRREKQEDAPTEYLVRPVANPEDEEEASDFEPEENGADEDAESEEEDEDDDDGGKIEAPPKRKRSNKDDSDDDDDDGGDDDQRPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIL7</accession>
    <name>A0A103XIL7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004987">
        <property type="protein sequence ID" value="KVH91445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIL7"/>
    <dbReference type="STRING" id="59895.A0A103XIL7"/>
    <dbReference type="Gramene" id="KVH91445">
        <property type="protein sequence ID" value="KVH91445"/>
        <property type="gene ID" value="Ccrd_006532"/>
    </dbReference>
    <dbReference type="OMA" id="WQDVSEV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000325">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF409">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="614"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="706" mass="78519" checksum="A39D6A4F9A300BD9" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ67</accession>
    <name>A0A103XJ67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Six-bladed beta-propeller, TolB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004925">
        <property type="protein sequence ID" value="KVH91559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ67"/>
    <dbReference type="STRING" id="59895.A0A103XJ67"/>
    <dbReference type="Gramene" id="KVH91559">
        <property type="protein sequence ID" value="KVH91559"/>
        <property type="gene ID" value="Ccrd_006418"/>
    </dbReference>
    <dbReference type="OMA" id="YDFRTIV"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF136">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118845" evidence="5">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="6">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="318" mass="34568" checksum="89A473A777CA6CA1" modified="2016-04-13" version="1">MKTSSLFVVDLIVCFLILGTVFSDTTSFNKLQLPPNVTGPESAAFDRQGGGPYVTVADGRILKWKNPTTGFVDFAYTSPNRTKQVCDGTNDLKLGSTCGRPLALSFNYKTSDLYITDAFLGLLVVGFNGGLATQLSGGYKYLSGIDVESYTGNVYVTDASLTYDIRNMTQPGFTPDSTGRLLKYDPRTQRVTVLLSGLSGGGGPAVSSDRKYVLVPDYVKKQIQRHWVQGPKRNTNDVFMTDCGIPKNIKRAVNGGEFWVAVEKMSEAQGLRVNGSAMVLQTVALSQFLNMSIAVVQEMNDALYVGSSRTDFVGVYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ71</accession>
    <name>A0A103XJ71_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_006308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004912">
        <property type="protein sequence ID" value="KVH91682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ71"/>
    <dbReference type="STRING" id="59895.A0A103XJ71"/>
    <dbReference type="Gramene" id="KVH91682">
        <property type="protein sequence ID" value="KVH91682"/>
        <property type="gene ID" value="Ccrd_006308"/>
    </dbReference>
    <dbReference type="OMA" id="KQPAINI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF380">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN (MAP) KINASE KINASE KINASE STE11, CRYPTOCOCCUS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="258"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH91682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="686" mass="79347" checksum="8CDE6EAFFE539FE1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKQ7</accession>
    <name>A0A103XKQ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aluminum-activated malate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_005418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aromatic acid exporter (TC 2.A.85) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004814">
        <property type="protein sequence ID" value="KVH92523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKQ7"/>
    <dbReference type="STRING" id="59895.A0A103XKQ7"/>
    <dbReference type="Gramene" id="KVH92523">
        <property type="protein sequence ID" value="KVH92523"/>
        <property type="gene ID" value="Ccrd_005418"/>
    </dbReference>
    <dbReference type="OMA" id="QFEDPEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH92523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="494" mass="56087" checksum="CA33563CEC710E8B" modified="2016-04-13" version="1" fragment="single">MAMAANHGFDRSKERLLLSRKGCSAFFEEPDNNGGTDASILDRIAKKWEDFQVFMVQIYEMGRSDPRQIIFAAKSGLALALVSTLIFFKESLRYFRATLSKGFNRAIGTVSAAILALCVAQASVWAGAWHEVVVVVSIFAAGTITSFVKLYPSMKAYEYGFRVFMLTFSIVLVSGTSHFYRTAISRLLLVAVGASVCLIVNICIYPIWSGEDLHKLVVKNFRGVASSLEGCVRSYLENVEYERIPSKILLGFAIWEPPHGRYRMFRYPWVQFIKVSGALRHCAFMVLREIGNKLEKLERLSPDFDLLDKVHEAAEDLQMLIDQKSYHLVNSEKWAAARRPKEFEDPEHLQELKEEETHMYTMGSSTSTLKPSHTFKNIDRHITNMSMNPSFANWGSSEDVLRQQVQWPSRLSVLGDVILNDREVRTYESASALSLTNFTSSLIEFVARLQNILNSYEELSEKARFSEPKNDLEKPEDRNSCLYVNVISTILIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLC1</accession>
    <name>A0A103XLC1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLC1"/>
    <dbReference type="Gramene" id="KVH92783">
        <property type="protein sequence ID" value="KVH92783"/>
        <property type="gene ID" value="Ccrd_005118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="77" mass="8748" checksum="5A4BF69392B4F8B9" modified="2016-04-13" version="1">MKMIGLHIKESYGKLTDGWKNLAYGIDSFGYEASCRNLEINTVGRIWPNACSSNPRWSKSQQKVSFCEPNTIGCIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM20</accession>
    <name>A0A103XM20_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 SUMO-protein ligase Nse2 (Mms21)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004793">
        <property type="protein sequence ID" value="KVH93150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM20"/>
    <dbReference type="STRING" id="59895.A0A103XM20"/>
    <dbReference type="Gramene" id="KVH93150">
        <property type="protein sequence ID" value="KVH93150"/>
        <property type="gene ID" value="Ccrd_004807"/>
    </dbReference>
    <dbReference type="OMA" id="VECKHIY"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="255" mass="28711" checksum="BCFA2D88CAD7E10A" modified="2016-04-13" version="1">MASTSAPRSETGSSRMKSAASTLCYDNQTLLADIRKAMGTMKEIGVSLEKQHKSQMVKELEAEFMELLKAYEDCANLSSAVDSVGNMYRPNEQVTDFKKLLDDEMAKTKRHSSSVPQVNQLFRQFREAIWNVHNSGQPMPGEEQEDIVMTSTQSILLNITCPLSGKPVGQLSEPVRSMDCKHIYEKKVIMEYIRSKHGQPKCPMAACPKKIVAERVVCDPLLRVEIEESCAMNKQTVRPNVIEDFTEDLEQEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMU5</accession>
    <name>A0A103XMU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004698">
        <property type="protein sequence ID" value="KVH93632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMU5"/>
    <dbReference type="STRING" id="59895.A0A103XMU5"/>
    <dbReference type="Gramene" id="KVH93632">
        <property type="protein sequence ID" value="KVH93632"/>
        <property type="gene ID" value="Ccrd_004316"/>
    </dbReference>
    <dbReference type="OMA" id="DINQEFS"/>
    <dbReference type="OrthoDB" id="623055at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000096">
        <property type="entry name" value="Basic helix-loop-helix (BHLH) DNA-binding superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="28807" checksum="8153BEDDD3F1EDF6" modified="2016-04-13" version="1">MEDIGDEYKNIGDEYKNYWETNMFLQTEEFDSWGGLEETFSGYYDSSSPDGPQSSAASKNIVSERNRRKKLNDRLFALRAVVPNISKMDKASIIKDAIDYIQHLHDQERIIQGDIMELESRKSESDVFDFDQEAEFMSYERLKKKKIEQSPDSSESRASPVEILELKVSYVGEKTVLVSLKCRKRRDTMVKICEVFESLKLNVVTANITAFSETIFKTLFLQADEEEIDLLKIQIHSAISAINDPPSPMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN25</accession>
    <name>A0A103XN25_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin/Peripherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004612">
        <property type="protein sequence ID" value="KVH93725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN25"/>
    <dbReference type="Gramene" id="KVH93725">
        <property type="protein sequence ID" value="KVH93725"/>
        <property type="gene ID" value="Ccrd_004220"/>
    </dbReference>
    <dbReference type="OMA" id="DWSILCY"/>
    <dbReference type="OrthoDB" id="761290at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="293" mass="33356" checksum="FB12B4746DEDE0C4" modified="2016-04-13" version="1">MAENANPIAETTQDVTVVAENRTTPNPAANKKHDPKPSSVKRIMFPLTTISFLLSFPILFCIVWLLYVKQCNCEHLLPLSKLQHGVVFALILLFVVSNSVVFLRSRFLMLGLIVVMVPLIVILTIGLALVGSYTIESRMIPGSPSWLKMMVNDDNNWYNIETCIYNTRTCQDLAVQSIMIKSYDFSMTKLSPIESGCCIPPTICDMEYLNATYWIKKTEVYDDLDGPYDIDCDLWQNNVTKLCYDCYACRKGFINTLRQKWYKLGVFLVVVTILLIVSHLLLFVASMQERYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNN4</accession>
    <name>A0A103XNN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mlo-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004564">
        <property type="protein sequence ID" value="KVH94171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNN4"/>
    <dbReference type="STRING" id="59895.A0A103XNN4"/>
    <dbReference type="Gramene" id="KVH94171">
        <property type="protein sequence ID" value="KVH94171"/>
        <property type="gene ID" value="Ccrd_003764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF109">
        <property type="entry name" value="MLO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="280" mass="31579" checksum="993F02AFEB0722B2" modified="2016-04-13" version="1">MVSLLNRFHDRSADGSIGKRLSEKIILTLQKSRHHVKLSNLEPEFTHVRDHDFIKNRFLGLGKRSAILGWLQFYGSVTKTDYAALRLGFITLLFFVGTKLEHIIIQLAHEVAEKHVAIEGEVAVKPSDDHFWFRRPRIILLLIHFILFQNAFEIAFFFWILVQFGLDSCIMGKLRYMIPRLVIGVFIQVLCSYSTLPLYALVTQMGSHFKKSIFEERIQTSLTSWAQKAKRKKALNVTTNGSSQDGPDGGGGGGSSGVGNDGVELQSIHIINDPPQSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNR6</accession>
    <name>A0A103XNR6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004560">
        <property type="protein sequence ID" value="KVH94216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNR6"/>
    <dbReference type="STRING" id="59895.A0A103XNR6"/>
    <dbReference type="Gramene" id="KVH94216">
        <property type="protein sequence ID" value="KVH94216"/>
        <property type="gene ID" value="Ccrd_003727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32204" checksum="9D3FF46716CE58CD" modified="2016-04-13" version="1">MGGDTISPSDSSIDDEDVMKKQLADRLSKKPYSRPGGLIGGKTAEDNNESIFGEKISRSLRDPYKCLESEANDRRMNNAYAQSVITYTPGLWVENVGGMTKSDYDVPITTTLLLIGPKGSGKSSLVNRISRVFEDDKFAPERAQVTYNSRSTNGTLFLQEYMIPRSSTSFCLYDTRSFSDHKPAIAITHGDLLSLSERARVRIYLGELLGVHPSKQTFDVPVFVAPLSDNSERTTDLTIIDMDSIPVWACLLLLVALGIIIITNRLAHGESIPEPSVEVDWKTIRHLWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP50</accession>
    <name>A0A103XP50_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_003646</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP50"/>
    <dbReference type="STRING" id="59895.A0A103XP50"/>
    <dbReference type="Gramene" id="KVH94260">
        <property type="protein sequence ID" value="KVH94260"/>
        <property type="gene ID" value="Ccrd_003646"/>
    </dbReference>
    <dbReference type="OMA" id="ATINHPD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000102">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF346">
        <property type="entry name" value="PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="116"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH94260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="493" mass="57453" checksum="C6BF5DB5E7D4D8BE" modified="2016-04-13" version="1">MDSARSWLHKFQPRDRLRSNNRRRDSMGGGEDEISGEEASAITKQKVAAAKKYIENHYKEQMRNLQERRERRILLEKKLADADVSEEDQNNLLKFLEKKETEYMRLQRHKMGADDFELLTMIGKGAFGEVRVCREKTTGCVYAMKKLKKSEMLRRGQVEHVRAERNLLAEVDSNCIVKLYCSFQDAEYLYLVMEYLPGGDMMTLLMRKDTLNEDEARFYVAETVLAIESIHKHNYVHRYAYNWLWYVLRTSFPLCILIFHYVFCNRDIKPDNLLLDRYGHLRLSDFGLCKPLDCSTLEDTDFSSVDNASGTSTSNERAAAPRRTQQEQLQHWQKNRRTLAYSTVGTPDYIAPEVLMKKGYALECDWWSLGAIMFEMLVGYPPFYSDDPMSTCRKIVNWKMHLKFPEEAKLSLEAKDLISKLLCNVNQRLGSKGADEIKSEHQINSSARSGPWRRMLSSKDINFVGYTYKNFEIVNDYQVPGMGIPLFFSHQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPB2</accession>
    <name>A0A103XPB2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_003512</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPB2"/>
    <dbReference type="Gramene" id="KVH94433">
        <property type="protein sequence ID" value="KVH94433"/>
        <property type="gene ID" value="Ccrd_003512"/>
    </dbReference>
    <dbReference type="OMA" id="CMNITTQ"/>
    <dbReference type="OrthoDB" id="780646at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000287">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase RKF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000390">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase RKF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043891">
        <property type="entry name" value="SPARK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF62">
        <property type="entry name" value="OS05G0423500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19160">
        <property type="entry name" value="SPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118980" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="308"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVH94433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="653" mass="72161" checksum="8B76DFB1B4C964B0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPM1</accession>
    <name>A0A103XPM1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichome birefringence-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004551">
        <property type="protein sequence ID" value="KVH94498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPM1"/>
    <dbReference type="STRING" id="59895.A0A103XPM1"/>
    <dbReference type="Gramene" id="KVH94498">
        <property type="protein sequence ID" value="KVH94498"/>
        <property type="gene ID" value="Ccrd_003418"/>
    </dbReference>
    <dbReference type="OMA" id="FINQETR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF19">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="3">
        <location>
            <begin position="140"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="48821" checksum="A454A498B15EFC77" modified="2016-04-13" version="1">MERQTSFSFKRTRFFVFYLTVSFSIIFLTFFSIWVFKTDPLFINQETRFQFSEIQSSSLTSVRNSPTQNSSTRLVAATVVNLNHTLFGKLLNTSQTPNISFSFDGFQKKSSGSQLPNLVSHKIEAVNGTNFSGFDVNSLFNATNMLELIKGKRLVFVGDSINRNQWESMLCLLITAIKDPKRVYEVHGRRITKDKGNYCFKFVDYKCTVEYYVSHFLVREGKARVGKKRLQTLRIDTVDKGSSRWKGADVLIFNTAHWWSHYKTKSGVNYYQEGDTVVPHLEVSTAFKKSMITWASWVDEYINPRKTQVVFRSSAPSHFAGGEWNAGGHCKEASQPLNRTASSIYPAKNAIVEEVIQQMKTPVKILNITSLSDYRIDGHPSIYGRRRGSTVRGEDCSHWCLPGVPDIWNQFLYVHLQSKVRNSYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ10</accession>
    <name>A0A103XQ10_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Basic-leucine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004531">
        <property type="protein sequence ID" value="KVH94715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ10"/>
    <dbReference type="STRING" id="59895.A0A103XQ10"/>
    <dbReference type="Gramene" id="KVH94715">
        <property type="protein sequence ID" value="KVH94715"/>
        <property type="gene ID" value="Ccrd_003218"/>
    </dbReference>
    <dbReference type="OMA" id="MGNYMAL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048653">
        <property type="term" value="P:anther development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071588">
        <property type="term" value="P:hydrogen peroxide mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002237">
        <property type="term" value="P:response to molecule of bacterial origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd14708">
        <property type="entry name" value="bZIP_HBP1b-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF13">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DOG1" evidence="11">
        <location>
            <begin position="278"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57565" checksum="5B7CF80F850B56EA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR14</accession>
    <name>A0A103XR14_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR14"/>
    <dbReference type="STRING" id="59895.A0A103XR14"/>
    <dbReference type="Gramene" id="KVH95295">
        <property type="protein sequence ID" value="KVH95295"/>
        <property type="gene ID" value="Ccrd_002639"/>
    </dbReference>
    <dbReference type="OMA" id="DAPFGWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="549" mass="62067" checksum="38CB8786225ABD8F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRW6</accession>
    <name>A0A103XRW6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004377">
        <property type="protein sequence ID" value="KVH95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRW6"/>
    <dbReference type="STRING" id="59895.A0A103XRW6"/>
    <dbReference type="Gramene" id="KVH95768">
        <property type="protein sequence ID" value="KVH95768"/>
        <property type="gene ID" value="Ccrd_002146"/>
    </dbReference>
    <dbReference type="OMA" id="WYKPQVS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000373">
        <property type="term" value="P:Group II intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044190">
        <property type="entry name" value="THA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594:SF4">
        <property type="entry name" value="OS04G0475500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594">
        <property type="entry name" value="PPR CONTAINING PLANT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31028" checksum="BD3B75C48EB4490E" modified="2016-04-13" version="1">MSMATRGMSCCGYGTVSIQTRMSCCDSFTEFSNSPSLEIGNKCRGSSMRITMRDRGKNRKPLQKGRNLSIEAIQTIQALKRAPKFSDKQQQVIHSKFTRLLKFDMMAILRELLRQDHSLLALMVFAEIQKEHWYKPEVSLYAEIILVLARNSLYDKVDMIFVELKSEKGRLEGKTEGFNALLENLMSYNMTGLAMDCFELMKEIDCEPDRSTFKLLVAHLESKGETGLSEGIKQEARKYYGDSLDFLDEQEDTVTAKLHSSIESADCRFGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSC0</accession>
    <name>A0A103XSC0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="5">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Extracellular space</location>
            <location evidence="5">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004367">
        <property type="protein sequence ID" value="KVH95959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSC0"/>
    <dbReference type="Gramene" id="KVH95959">
        <property type="protein sequence ID" value="KVH95959"/>
        <property type="gene ID" value="Ccrd_001960"/>
    </dbReference>
    <dbReference type="OMA" id="IFYDYCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044042">
        <property type="term" value="P:glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989401" description="Xyloglucan endotransglucosylase/hydrolase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR608264-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="23489" checksum="8277CF21ADEA7E4A" modified="2016-04-13" version="1">MASSSSFLFTTLFLSLYVCSVISTAKFDQLFQPYWAADHFSFDGEAVNMKLDNFSGAGFSSKSKYMFGKVNIQIKLVEGDSAGTVTAFYMSSDGPKHHEFDFEFLGNTTGEPYVVQTNVYVNGVGNREQRLNLWFDPTKDFHSYSVLWNQRQVVGGWWDRPVLSELNVHQSHQLIWVRANHMIYDYCNDAARFASVPVECEHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSR7</accession>
    <name>A0A103XSR7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004348">
        <property type="protein sequence ID" value="KVH96199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSR7"/>
    <dbReference type="STRING" id="59895.A0A103XSR7"/>
    <dbReference type="Gramene" id="KVH96199">
        <property type="protein sequence ID" value="KVH96199"/>
        <property type="gene ID" value="Ccrd_001712"/>
    </dbReference>
    <dbReference type="OMA" id="QATQRHR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000557">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="207" mass="23342" checksum="2E6BC28203E7890C" modified="2016-04-13" version="1" fragment="single">AVLKNISTPAFLPLRKVSRTQRKTFQSPPLLCSIDRMNQQVQKNTLYVGGLAEEANETILHSAFIPFGDIKDVKTPLDQATQKHRSFGFVTFLEREDAAAAMDNMDGAELYGRVLTVNYALPEKIKGGEQGWAAQPIWADADTWFERQQQEEEMQRIQAENRASMQAAEELHRKKLADEREGEKDEADTKDDPMAMAEAEAVKQNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU98</accession>
    <name>A0A103XU98_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="5">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_000944</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003964">
        <property type="protein sequence ID" value="KVH96961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU98"/>
    <dbReference type="STRING" id="59895.A0A103XU98"/>
    <dbReference type="Gramene" id="KVH96961">
        <property type="protein sequence ID" value="KVH96961"/>
        <property type="gene ID" value="Ccrd_000944"/>
    </dbReference>
    <dbReference type="OMA" id="WWLHRAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF4">
        <property type="entry name" value="NADH:UBIQUINONE REDUCTASE (NON-ELECTROGENIC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="106"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="16">
        <location>
            <begin position="436"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH96961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="506" mass="55850" checksum="C9D0A420DABD6F5B" modified="2016-04-13" version="1">MAFARISRNWRRSSGTGTINRYINNNDIPSYSSSDSTLNAKTFGKMSYLESKTKVDHMNFEGRGTQAIQGYRFGHAEGISEDYSDSETENVQYASLEATKAGDKPRVVVLGTGWAACRLLKGIDTTIYDVVCISPRNHMVFTPLLASTCVGTLEFRSVAEPVGRIQSALAKDPNSYFYLSSCYHIDTDKHETVSDNGLPHEPSRFKVAYDKLVIASGSEPVTFGIKGVSEEEKERMLHCVVIGGGPTGVEFSGELSDFIVRDVCQRYAHVKNYVRVTLIEANEILSSFDVGLRQYAMKHLTKYGVRLVRGVVKEVHPKKLILSNGSVVPYGLLVWSTGVGPSEFIKSLDLPKSPGGRIGVDEWLRVPSVEDVFALGDCAGFLENTGRQVLPALAQVAEREGKYLVELFNNKIGKQNAGKAGSANDLVLGDPFVYKHLGSMASVGRYKALVDLSQSKDAKGVSMAGFVSWLIWRSAYLTRVLSWRNRFYVAINWATTLVFGRDNTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVR0</accession>
    <name>A0A103XVR0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVR0"/>
    <dbReference type="STRING" id="59895.A0A103XVR0"/>
    <dbReference type="Gramene" id="KVH97769">
        <property type="protein sequence ID" value="KVH97769"/>
        <property type="gene ID" value="Ccrd_000126"/>
    </dbReference>
    <dbReference type="OMA" id="FSEFTEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36034:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36034">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="861" mass="94133" checksum="348EF0D6F51DECF9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVR9</accession>
    <name>A0A103XVR9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003818">
        <property type="protein sequence ID" value="KVH97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVR9"/>
    <dbReference type="Gramene" id="KVH97793">
        <property type="protein sequence ID" value="KVH97793"/>
        <property type="gene ID" value="Ccrd_000075"/>
    </dbReference>
    <dbReference type="OMA" id="DQFIKFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000239">
        <property type="entry name" value="probable BOI-related E3 ubiquitin-protein ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647:SF51">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="49248" checksum="6D5E30A7B728C8E4" modified="2016-04-13" version="1">MPYHFFNQLLPLYPLSLCIHNFLSLKVSILIDYSLSIGSLIVSRYEIFIAEIIFDLLLSLSLLLWFDYWSGSSNDLPDLLFFLLVILQDLARFWTSERKMFGGSNTNSLVPVFLDENLFQYPSNQLQLFGNVPATRNVDPVNYSVREHNSPVFRSNKRPREAEANLMQKKLQISLNQNFYNEETDRPSTIPTPHPVSTGLKLSYDDEERNSSITSASGSMTAAPSIMSSFGDGVTNELDRHNEELERFIMIQVGENMVKGVKEIRQRHMATFLASIGKGIEKKIREKDLEIETINLKNKDLVGRIKQVANEAQNWHYRAKYNESMVNMLRTNLQQALAQGNEQQQQVKEGFGDTDVEYDAVSSIDPNNYLNAPGKSLKDNNSSMMVCKACKAKEVSVLVMPCRHLSLCKDCDRGVNVCPVCQIVKTVGVEVYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW72</accession>
    <name>A0A103XW72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003811">
        <property type="protein sequence ID" value="KVH98048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW72"/>
    <dbReference type="STRING" id="59895.A0A103XW72"/>
    <dbReference type="Gramene" id="KVH98048">
        <property type="protein sequence ID" value="KVH98048"/>
        <property type="gene ID" value="Ccrd_023730"/>
    </dbReference>
    <dbReference type="OMA" id="YIHTINT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="719" mass="76145" checksum="ADF132F8729CDE46" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW81</accession>
    <name>A0A103XW81_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_023763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW81"/>
    <dbReference type="STRING" id="59895.A0A103XW81"/>
    <dbReference type="Gramene" id="KVH98010">
        <property type="protein sequence ID" value="KVH98010"/>
        <property type="gene ID" value="Ccrd_023763"/>
    </dbReference>
    <dbReference type="OMA" id="HRVQANG"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH98010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="14785" checksum="01BF2ECAD6ED5D2A" modified="2016-04-13" version="1">MSGKGAKGLIMGKASSSALNGSNNKDKDKKKSISRSSRAGLQFPVGRVHRLLKTRVSASGRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDTLIKGTIAGGGVIPHIHKSLINKSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWF1</accession>
    <name>A0A103XWF1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Auxin response factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWF1"/>
    <dbReference type="STRING" id="59895.A0A103XWF1"/>
    <dbReference type="Gramene" id="KVH98104">
        <property type="protein sequence ID" value="KVH98104"/>
        <property type="gene ID" value="Ccrd_023674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF162">
        <property type="entry name" value="AUXIN RESPONSE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Auxin response factor" evidence="9">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="45070" checksum="737F7CB898DE24FF" modified="2016-04-13" version="1" fragment="single">MTSSEVSSKGNSSMRGDRDTFSLSGFSDKNDAVGDSRTVPAVSGAVDADVALYKELWRACAGPLVTVPRENELVFYFPQGHIEQVEASTHQVPEQQMPVYDLPSKILCRVVNVQLKAEQETDEVFAQITLMPEPDVSLPLLPMNPQDVNSVKKEPAPPAQSRFHVHSFCKTLTASDTSTHGGFSVLRRHADECLPPLVRHVKATSNTGAGSEGFAWKRMALQAHISGTSPAEFIVPYDQYMESIKNNYSIGMRFKMRFEGEEAPEQRFTGTVVGIEESDPKRWPESKWRCLKARDGRSSAFGEYSVHLNRRGSEQQHGKWMMPPPLPSYLHMPSHSTEVMPKSPLSHQNEVRKPQDGNCKIFGVPLAGNKVASDEAGNSHQGLQSQSYPTLESDQRFEQSKSPKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWL8</accession>
    <name>A0A103XWL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWL8"/>
    <dbReference type="STRING" id="59895.A0A103XWL8"/>
    <dbReference type="Gramene" id="KVH98219">
        <property type="protein sequence ID" value="KVH98219"/>
        <property type="gene ID" value="Ccrd_023582"/>
    </dbReference>
    <dbReference type="OMA" id="WESAMIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF36">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="187" mass="20987" checksum="8BE0BA1541393041" modified="2016-04-13" version="1">MRPHIVLFGDSITEQSFRYGGWGASLTDTYSRKADIVVRGYGGYNTRWALFLLHHIFPLGSTTPPVAATIFFGANDAALAGRTSERQYVPLEEYKENLRKIVRHLKECSPTMLIVLITPPPIDEEGRKEYATDGLHLTPDGNGVVFEEVVRAFKGAWLSATEMPSDFPHHSEIDPQSPQTVFHQRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWN4</accession>
    <name>A0A103XWN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003804">
        <property type="protein sequence ID" value="KVH98270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWN4"/>
    <dbReference type="STRING" id="59895.A0A103XWN4"/>
    <dbReference type="Gramene" id="KVH98270">
        <property type="protein sequence ID" value="KVH98270"/>
        <property type="gene ID" value="Ccrd_023502"/>
    </dbReference>
    <dbReference type="OMA" id="MHAYCRD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF81">
        <property type="entry name" value="OS01G0618100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="35540" checksum="DE75D610CF3AC254" modified="2016-04-13" version="1">MADGSLTFDMPRVKLGNQGLQVSRLGYGCMGLTGAYNNPLRVEEGIKVLKEAFDRGITFFDTADIYGVEHANEILVGKALKELPREKIQLATKFGIVKMDPTKITVKGGAEYARSCCEGSLKRLGVDYIDLYYIHRIDTIVPIEDTMEELKKMVAEGKIKYIGLSEANADTIRRAHAVHPITALQMEYSIWTREIEEELVPLCRFTGENFMKNKVVYERVESMAKRHECTPAQLALTWLLHQGEDVVPIPGTTKIKNLDENVGSVKVKLTKEDVTEICNVVPINDIAGCKTSEAPLLCLVEIRKFTTKEQQLIILMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWU6</accession>
    <name>A0A103XWU6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">START-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWU6"/>
    <dbReference type="STRING" id="59895.A0A103XWU6"/>
    <dbReference type="Gramene" id="KVH98325">
        <property type="protein sequence ID" value="KVH98325"/>
        <property type="gene ID" value="Ccrd_023446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="154"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="34278" checksum="2205E3DAE6844C3C" modified="2016-04-13" version="1" fragment="single">ALCRNRRDFPVNSYLITASRLGLSILVADSYRSKNIYSSSSDQLHCFTMSSLKSTSKAVRQLIICKNGGTRLVRCLQNNPELETCVQSRYFRSIGSVETLPSSCQMVGAAHKDPPFLQNTSSGILSQRRGFLGCGDGDEGSNVLSKVHEEKRIMGYSPEQLFAVVAAVDMYQDFLPWCQRSDIIQRHSDASFDAELEIGFKFLVESYVSHVEMIKPKMIKTTSSQSSLFDHLINIWEFHPGPVPGTCNLHFFVDFKFQSPLYSQMASMFFKEVVSRLVNSFNDRCHLIYGPGIPVREKLIERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX50</accession>
    <name>A0A103XX50_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Plastid</location>
            <location evidence="8">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01003791">
        <property type="protein sequence ID" value="KVH98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX50"/>
    <dbReference type="STRING" id="59895.A0A103XX50"/>
    <dbReference type="Gramene" id="KVH98538">
        <property type="protein sequence ID" value="KVH98538"/>
        <property type="gene ID" value="Ccrd_023229"/>
    </dbReference>
    <dbReference type="OMA" id="GWSIDSW"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0104">Cadmium</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="350"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="515" mass="56966" checksum="AFDE2BA875267A94" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXZ7</accession>
    <name>A0A103XXZ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003643">
        <property type="protein sequence ID" value="KVH98865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXZ7"/>
    <dbReference type="STRING" id="59895.A0A103XXZ7"/>
    <dbReference type="Gramene" id="KVH98865">
        <property type="protein sequence ID" value="KVH98865"/>
        <property type="gene ID" value="Ccrd_022909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000199">
        <property type="entry name" value="Thioredoxin-like 1-2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF17">
        <property type="entry name" value="THIOREDOXIN-LIKE 1-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="149"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="37605" checksum="CCD5282303278923" modified="2016-04-13" version="1">MTWTGIFYLWVHSNLVKWIKLLSKEKETLKTPTNPFLSHSFPFQITTSIFLSHHSKKIHIFSGFSRILHFITSSRCFFVIWILYHLIWSFLWFFWGVESWLTSLYVQQHLSMAASSSSFNPISFPASFEEALTNSNGFLSPSIVSTDFLKKGSQIPSDHKGLTSSCWNAKTPVLTHASKSLSKPMRWWEKTLPPNMMEIKSAQELVDKLSNSGDRLVILDFYSPGCGGCKALHPKICQLAESNPNAIFLQVNYEALKPMCHSLRIHVLPFFRFYKGSEGKLCSFSCTIATIKKFKDALSKHGTDGGDVGAAKGLEESELLTLASIVKSHIICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYD8</accession>
    <name>A0A103XYD8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYD8"/>
    <dbReference type="STRING" id="59895.A0A103XYD8"/>
    <dbReference type="Gramene" id="KVH99133">
        <property type="protein sequence ID" value="KVH99133"/>
        <property type="gene ID" value="Ccrd_022661"/>
    </dbReference>
    <dbReference type="OMA" id="NWWESST"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF46">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="302" mass="33400" checksum="A3AAB3A3141C15DD" modified="2016-04-13" version="1" fragment="single">RGDQRNDHHQSGYQTLIQEDHSLSSNSNFQDSQWKLSHKMYSDSPSEFKQVNVRSFRLDEPVNYSDENGLNPSFQSMDHSYGSSTVIQSLFGSDNTTNQQQDSGFDQNQAMSTYSYQSGYGGITLSGGGTGSGEYPPPPQEFSVNSSPPKVPSPNIASQLHFSNNARFWNASAASMNDTASEMVKKSSNKPSSTKRPRNENPPLPAFKVRKEKMGDRITALQQLVSPFGKTDTASVLSEAIEYIKFLHEQVNICSEKAGEGSPIRQDLRSRGLCLVPISSTFPVTHETTVDFWTPSFGGTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZK8</accession>
    <name>A0A103XZK8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bicarbonate transporter, eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZK8"/>
    <dbReference type="STRING" id="59895.A0A103XZK8"/>
    <dbReference type="Gramene" id="KVH99799">
        <property type="protein sequence ID" value="KVH99799"/>
        <property type="gene ID" value="Ccrd_021979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF40">
        <property type="entry name" value="BORON TRANSPORTER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="17302" checksum="399FDD8F5D7C62EF" modified="2016-04-13" version="1">MANRKKSDNHLFNLFQRSKSPAGELILLWIIVYPRGRVVALTISAMDTPKTPFSGIKKDVRGRLQCYKQDWIGALGSGARYLAIIHIEKLTNCTDAPPLWFSSFSRILAPTAYIFFASALPVIAFGEQLNKDTGTNRYIMCNLSFIDLPWYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y026</accession>
    <name>A0A103Y026_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y026"/>
    <dbReference type="STRING" id="59895.A0A103Y026"/>
    <dbReference type="Gramene" id="KVI00041">
        <property type="protein sequence ID" value="KVI00041"/>
        <property type="gene ID" value="Ccrd_021693"/>
    </dbReference>
    <dbReference type="OMA" id="HEPNWQL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11046">
        <property type="entry name" value="CYP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF183">
        <property type="entry name" value="CYTOCHROME P450 97B3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="527" mass="59493" checksum="B34968E9F05712DB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0E1</accession>
    <name>A0A103Y0E1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING-CH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003396">
        <property type="protein sequence ID" value="KVI00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0E1"/>
    <dbReference type="STRING" id="59895.A0A103Y0E1"/>
    <dbReference type="Gramene" id="KVI00219">
        <property type="protein sequence ID" value="KVI00219"/>
        <property type="gene ID" value="Ccrd_021550"/>
    </dbReference>
    <dbReference type="OMA" id="HECIARS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46158">
        <property type="entry name" value="OS02G0165000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46158:SF1">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="438" mass="48200" checksum="9908B58E5B9C511B" modified="2016-04-13" version="1">MKSQENGGFRSAEEGYDSSNDQREQNLVLEIPSRTLQPSSSQEFVHIKMPPTPTPSHKKVNFNLLASPDTCSSQTKSSKKSSLLPKLSLKNRNTISDIVIPAALASIPQEKPSIARSWSLTKMLIKMTPSLPFALIEHSDRESGLRRAGGSLNLQTKVHECIARSQSVPIINENTNVKRMDSFFPEEEAVCRICLIELCEGGETLKMECSCKGELALAHQECAVKWFSIKGNKTCDVCHQDVQNLPVTLQRIQSTVRHQDTGATTVGKMGTGSIALSIPFSCVLGLLSTMTSSAMVERRFAWLYASIQFTFVVVFAHIFYSMVHVQPILSILLATFAGCGVAICGRSIIVEVLRLRRWWHDRSNQQHDSLSVEIAPPSETPLPSLPPPPPPSYIASPDVLLYVEPQHDHVTSLSCPPPPPPPPPSPPHCTENHKTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1S0</accession>
    <name>A0A103Y1S0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003170">
        <property type="protein sequence ID" value="KVI00926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1S0"/>
    <dbReference type="STRING" id="59895.A0A103Y1S0"/>
    <dbReference type="Gramene" id="KVI00926">
        <property type="protein sequence ID" value="KVI00926"/>
        <property type="gene ID" value="Ccrd_020812"/>
    </dbReference>
    <dbReference type="OMA" id="HECWHEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000763">
        <property type="entry name" value="Os01g0748600 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF140">
        <property type="entry name" value="INACTIVE PROTEIN TYROSINE KINASE PTKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="125"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="450" mass="51394" checksum="5DA659324688BBB9" modified="2016-04-13" version="1">MESMPNVRFMLGRQSSMATDRVSGSDSDSEHEEVNRAEAIDPRLRLMFFSSEGDLEGIKELLTSGTDVNFKDIDNRTALHVAACQGFSNVAELLLERGAEVDPRDRWGSTMQSIIRTMMLSNFWRNMVPNLWQMAPMHVQNAREVPEYEIEPKEFDFTNSIDITKGTFIMASWRGTQVAVKKLGDEVFTDEEKVRAFRDELELLQKVRHPNVVQFLGAVTQSSPMMIVTEYLPKGDLRALLKRKGALKPATALRFARDIARGMNYLHENKPEPIIHMDLEPSNILLDDSGHLKVADFGISKLLKGTGKVKQEKLMTCQDTACRYFAPEVFRNEDYDTKVDVFSFALILQEMIEGCLPFSAKRENDVPKAYAAKERPPFNAPSKKYAHECWHENPARRPTFRQIIPRLESIHSSLNHKWRWKVRPLKCFQKMGSWNSEGSGTSSRDRSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1U9</accession>
    <name>A0A103Y1U9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003155">
        <property type="protein sequence ID" value="KVI00967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1U9"/>
    <dbReference type="Gramene" id="KVI00967">
        <property type="protein sequence ID" value="KVI00967"/>
        <property type="gene ID" value="Ccrd_020779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="207" mass="23244" checksum="6CAA5FB3382EC78B" modified="2016-04-13" version="1" fragment="single">MLQIEYEAQISAIEQKIKLLESFETVTNIPVDESLKTKAIPEQTAYGKESTNSLKANALLKSINKDNTSPDHMLGKTSRLVNSNPSAEGLSKMTTLSSNKMQEQKLAPSYLRALKDNSQTRYYVNYRGPHKGVYTDWGVVEAFCKEGKTTAREEHDDVIDDVSLLSSAMAREERDDVIDDVSLLSSAMLFLNQNLTQFLNQNLTQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2H5</accession>
    <name>A0A103Y2H5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003121">
        <property type="protein sequence ID" value="KVI01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2H5"/>
    <dbReference type="STRING" id="59895.A0A103Y2H5"/>
    <dbReference type="Gramene" id="KVI01309">
        <property type="protein sequence ID" value="KVI01309"/>
        <property type="gene ID" value="Ccrd_020450"/>
    </dbReference>
    <dbReference type="OMA" id="EFMRIEE"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF50">
        <property type="entry name" value="F21B7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="459" mass="51038" checksum="87A130E8F008DA29" modified="2016-04-13" version="1">MAPFSSSWVQERHFPDLLIPISIDRAFSVLPEGPIQAQDGDTLYLSNLDDIIGARVFTPTVYFYTATRSSFDDVVDILKDALGKVLVPYYPFSGRLRGTNNGKLEVFFGPNQGALMVQAHTELSLDRLGDLTVPNPAWSNLVYKFPNEGNYKVIDMPLLIAQVTRFSCGGFSLGLRICHCICDGLGAMQFLGAWASTAKTGSLVVDPNPCWDREIFVPRDPPMVKYPHVEFMKIDDGSNLTISLWEVKPLQKCYWLSREFQAHLKSVARPMDSLGCTTFDAMAAHVWRSWVKALNVKPLDFGLRLTFSVNARSKLKNPPLKDGFYGNVVCVACATCTVSNLINGSLQDVTRLVREARLGVSEEYLRSTIDFVEVDRPNKLEFGGKLTITQWTRFSMYESSDFGWGRAIYVGPIDLTPTPQVCVLLPEGVADSSGAMVVCICLPEAAAHRFKELLCLMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2P8</accession>
    <name>A0A103Y2P8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003100">
        <property type="protein sequence ID" value="KVI01414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2P8"/>
    <dbReference type="STRING" id="59895.A0A103Y2P8"/>
    <dbReference type="Gramene" id="KVI01414">
        <property type="protein sequence ID" value="KVI01414"/>
        <property type="gene ID" value="Ccrd_020305"/>
    </dbReference>
    <dbReference type="OMA" id="QLIPMED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000014">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="2">
        <location>
            <begin position="35"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="480" mass="54598" checksum="F237AAEB8677E0F2" modified="2016-04-13" version="1">MGNLMGTFESFRKAFGALKDSTKVGLAKVNSEFKVAIKTLIVFHRTLREGDPSFKEELLNYMHRSHVFQISNFKDDSSSLGKNNMNPSFRTIHCIFCNENTDLIVIDYDFVKAYSRTRLMSGEELLEQLPTMQQLLHRLIGCQPEGAAYYNYLVQYALALVLKESFKIYCAINDGIINLVDLFFDMPKPDAVKALNIYKKAGKQPPPSFLTTMEEYIREAPAVASVLMKRLEYEDIGEDDQQAGDDNSHESENNNEQVEDKEAVQAKPELEIVKDEHGLREINQKAAELDERNAMALAIVENGSHPQSSSIDWDEIKNTPGWELALVENNINTSNNTSQAQTCGGFDKFLLNSLYEDDAARRQIQLQNAGYNVGYRYDSRYNPFNQGPLPPPPHQLQDPFAMSNGVSPMMNVQMAMMQQQQQMTMNQQPPYQNQYQQLYHQQNMMVPYNNGYPMGTSNPFADVYEYPQSSTQPHGNHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5W3</accession>
    <name>A0A103Y5W3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase, beta-Grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002551">
        <property type="protein sequence ID" value="KVI03100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5W3"/>
    <dbReference type="STRING" id="59895.A0A103Y5W3"/>
    <dbReference type="Gramene" id="KVI03100">
        <property type="protein sequence ID" value="KVI03100"/>
        <property type="gene ID" value="Ccrd_018608"/>
    </dbReference>
    <dbReference type="OMA" id="LSECHET"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000003">
        <property type="entry name" value="Glutamine synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF117">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="3">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="13518" checksum="D45316C5F7DD1A30" modified="2016-04-13" version="1">MALLNDLINLNLTDSTKKIIAEYIWIGGSGMDLRSKARTLPGPVSDPKKLPNWNYDGSSTGQAPGEDSEVIIYPQAIFKDPFRGGNNILVICDAYTPAGEPIPTNKRHAAAKIFSHPEVEKEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6W7</accession>
    <name>A0A103Y6W7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002337">
        <property type="protein sequence ID" value="KVI03622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6W7"/>
    <dbReference type="STRING" id="59895.A0A103Y6W7"/>
    <dbReference type="Gramene" id="KVI03622">
        <property type="protein sequence ID" value="KVI03622"/>
        <property type="gene ID" value="Ccrd_018084"/>
    </dbReference>
    <dbReference type="OMA" id="FIRHRII"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36735">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36735:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="21996" checksum="DAC7999AF10FAEDF" modified="2016-04-13" version="1" fragment="single">EPIGSNPTHDSPVGADVTPFKTLFVWCREASDSTMVVTIATISLPPFPAPESFKYHAIKSPNRSSLSILSPPTTNFIRHRIILPRTTGNRPVSATPNGIFLLSEASPAENSDKIVAAVAADNGDGVSVVISVLLFIAFVGLSVLTIGVVYIAVTDYLQKREKDKFEKEEAEKAKRGGKKKRVRSRAGPKGFGQKINDDNYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7H0</accession>
    <name>A0A103Y7H0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNARE associated Golgi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002320">
        <property type="protein sequence ID" value="KVI03938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7H0"/>
    <dbReference type="STRING" id="59895.A0A103Y7H0"/>
    <dbReference type="Gramene" id="KVI03938">
        <property type="protein sequence ID" value="KVI03938"/>
        <property type="gene ID" value="Ccrd_017741"/>
    </dbReference>
    <dbReference type="OMA" id="GWHEISR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF24">
        <property type="entry name" value="OS07G0655900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="176"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="40966" checksum="D0D1B36BFDE5D7FC" modified="2016-04-13" version="1">MSVKGFMKCYKITVLLHQRSMVPPWSVGSTGKQVYNCLAQKSRFERNLNPDHRAPEFVHLEFSFILNSINLANVVGLRARSSLKPDLTNEDDEDFRPWRRRLLSSVKMNVSFSFTWSSAVRASIFLLLLGVFAFACFSLPVEKILKDFLLWIKTELGPLGPLVLAIAYIPLTVFAVPASVLTLGGGYLFGLPVGFVADSIGATLGATAAFLVGKTIGRSYVISKLRKYPKFQAIAIAIQRSGFKIVLLLRFVPLLPFNVLNYLLSVTPVRLWEYMLATWLGMMPITFVFVYIGTTLKDLSDVTHGWHEISRTLLMIVYIIRVAKASLEKALAENGAIDGIDLDSPGLPILADSALGLHQPLISTTADDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9D7</accession>
    <name>A0A103Y9D7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001899">
        <property type="protein sequence ID" value="KVI04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9D7"/>
    <dbReference type="Gramene" id="KVI04925">
        <property type="protein sequence ID" value="KVI04925"/>
        <property type="gene ID" value="Ccrd_016747"/>
    </dbReference>
    <dbReference type="OMA" id="DEPMCAV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF177">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="19343" checksum="44FEFA8CC22DB601" modified="2016-04-13" version="1">MADDNNGVLTEVYVVLLIIALGALLIAIYHCISMLWWDLHRHRRRRGPTEIQLEGNDVSFENSVAGLIPAHKHKKGIGSEDDEPMCAVCLSEFEEGEELRTLPDCMHSFHVSCIDMWLYSHRNCPICRMDAATTASPLMEIIYIVDPQHDQEEVVSRPNMPQDLAVQSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9G5</accession>
    <name>A0A103Y9G5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARR-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001893">
        <property type="protein sequence ID" value="KVI04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9G5"/>
    <dbReference type="STRING" id="59895.A0A103Y9G5"/>
    <dbReference type="Gramene" id="KVI04976">
        <property type="protein sequence ID" value="KVI04976"/>
        <property type="gene ID" value="Ccrd_016696"/>
    </dbReference>
    <dbReference type="OMA" id="MMGTAHH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010017">
        <property type="term" value="P:red or far-red light signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000214">
        <property type="entry name" value="Two-component response regulator-like PRR37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF117">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR-LIKE APRR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="93"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="12">
        <location>
            <begin position="662"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="594"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="716" mass="78190" checksum="C0F8CD67E3111635" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9W0</accession>
    <name>A0A103Y9W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_016449</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001885">
        <property type="protein sequence ID" value="KVI05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9W0"/>
    <dbReference type="STRING" id="59895.A0A103Y9W0"/>
    <dbReference type="Gramene" id="KVI05211">
        <property type="protein sequence ID" value="KVI05211"/>
        <property type="gene ID" value="Ccrd_016449"/>
    </dbReference>
    <dbReference type="OMA" id="GQFMVFN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000896">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000292">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF44">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE CLAVATA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119519" description="non-specific serine/threonine protein kinase" evidence="19">
        <location>
            <begin position="27"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="726"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="956" mass="105389" checksum="996C98292CB741CB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB19</accession>
    <name>A0A103YB19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB19"/>
    <dbReference type="Gramene" id="KVI05800">
        <property type="protein sequence ID" value="KVI05800"/>
        <property type="gene ID" value="Ccrd_015862"/>
    </dbReference>
    <dbReference type="OMA" id="HYESKGM"/>
    <dbReference type="OrthoDB" id="1908822at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="16773" checksum="523DB7C09586E0AD" modified="2016-04-13" version="1">MMQGTGESNPLSSATADSPPSSIGLGMGMGMGMGIGAAMRAEKDKGRKPRKKLPTPKEMIAHYESKGMQSQEASLKVIDDLQNLLMRVVTTAKNTNTNLDPINSRLLRLESKLDSKPGYTQTLGIGIVSGAVIRVFPQVAASVVHIWNCVRESTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBE2</accession>
    <name>A0A103YBE2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bicarbonate transporter, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBE2"/>
    <dbReference type="STRING" id="59895.A0A103YBE2"/>
    <dbReference type="Gramene" id="KVI05984">
        <property type="protein sequence ID" value="KVI05984"/>
        <property type="gene ID" value="Ccrd_015650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF40">
        <property type="entry name" value="BORON TRANSPORTER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="272"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="49232" checksum="F7C17CA2728CF0CB" modified="2016-04-13" version="1">MEHMRSPFRGIVEDVRGRALILAPTTYIFFASALPVIAFGEQLSRDTDGSLSTVETLISTAICGLIHSILGGQPLLILGVAEPTIIMYTYLYNFAKGKQALGQHLFLAWAGWRNFWDVNCRSFHSRGRKVSEFKVPKNDDPNKAKYQFQWLYANGLLAIAFSFGLLYTALKSRKARSCWLSKKNSTSRILQRKLTHRKLRSKTPSICSNNLKVVYQFIRKKLVASAKESIKQKASNSEIYNKMQTDAVMKVEEDTKLGKFDPEEHIDAHLPVRVNEQRVSNLLQSLLLAASITAMPLIKLIPTSLLWGYFAYMAIDSLPGNQFWERILLLFVHASFVESVPFRSIAIFTIFQIMYFLVCYGVTWIPIAGILFPVPFFLLISIRQHILPKLFQLHHLRELDAAEYEEIAGEVTMCDAEILDELTTSRGELKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCR6</accession>
    <name>A0A103YCR6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014943</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01001744">
        <property type="protein sequence ID" value="KVI06701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCR6"/>
    <dbReference type="STRING" id="59895.A0A103YCR6"/>
    <dbReference type="Gramene" id="KVI06701">
        <property type="protein sequence ID" value="KVI06701"/>
        <property type="gene ID" value="Ccrd_014943"/>
    </dbReference>
    <dbReference type="OMA" id="MKDVHNS"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025298">
        <property type="entry name" value="DUF4094"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF275">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13334">
        <property type="entry name" value="DUF4094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF4094" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI06701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="485" mass="55635" checksum="05C9CA35B6E86DB1" modified="2016-04-13" version="1">MLKMRGKLVPGKIILMLCMASFLVGTLFTRHTWPYPPINNDLRFKNHQHKISLTIPRDCDHKRKLVEQSSGDIMGEVEKTHQAIRSLDKTISTLEMELEAARTSLTRAKFPSSNKTSSLQKAFVVIGINTAFSSKKRRDSVRETWMPTEQILTHPLVNACEYHWAKDPLAFPRAKLNKLAKEKGIIVRFVIGHSATPGGVLDRAIDAEEEKYQDFLRLNHVEGYHELSTKTRVYFSTAVSIWDAEFYVKVDDDVHVNLGMLVTALARYRSKPRTYIGCMKSGPVLFQKSVNFFSSFVYSYSFINFRMPSPKYNKIGTKYYCHVKNLVPFLSRRMLAKCLLETELSRGVRYHEPEYWKFGEEGNKYFRHATGQIYAISKDLAAYISSNSGILHRYANEDVSLGSWLIGLDVQHIDDRSIGICKSVERMKFVHDSCGEGDVVVWNRITHTPKYNIRVSWDELNYQGDIDDADKVIDPLLWTVPNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE32</accession>
    <name>A0A103YE32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_014235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be a cell surface adhesion protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001507">
        <property type="protein sequence ID" value="KVI07407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE32"/>
    <dbReference type="STRING" id="59895.A0A103YE32"/>
    <dbReference type="Gramene" id="KVI07407">
        <property type="protein sequence ID" value="KVI07407"/>
        <property type="gene ID" value="Ccrd_014235"/>
    </dbReference>
    <dbReference type="OMA" id="IYDAMSP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000011">
        <property type="entry name" value="Fasciclin-like arabinogalactan protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044654">
        <property type="entry name" value="FLA15/16/17/18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32499:SF21">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32499">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119621" evidence="10">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="11">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="11">
        <location>
            <begin position="259"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI07407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="441" mass="48573" checksum="6CB0D0EE9BD20CD9" modified="2016-04-13" version="1" fragment="single">MASIRKSFTILFVLSVLIQFATAALSGKPTNATTQINSNSVLVALLDSRYTELAELVEKALLLQKLEEAVTNHNITIFAPRNEALERELDPEFKRFLLEPRNLHSLQTLILHHIVPSRLAQSEWPDESTQHTTLSPDPIHLSNLDSVKLAGNAEVVRLDDVFRPDGIIHGISRLLIPKSVQQDFNNRRSLRAISAVKPEGAPEVDPRTNRLKKPAPSVPAGSSPVLPIYYAMAPGPSLAPAPAPGPGGPHHHFDGESQVKDFIQTLLHYGGYNEMADILVNLTNLATEMGKLVSEGYVLTVLAPNDEAMAKLTADQLAEPGAPERIMYYHIVPEYQTEESMYNAVRRFGKVRYDTLHVPHKVVAQEADGSVKFGDDDETAYLFDPDIYTDGRISVQGIDGVLFPASEKTDSKKPESITTVDTIQSKPKSRRGTLTILLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE74</accession>
    <name>A0A103YE74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE74"/>
    <dbReference type="Gramene" id="KVI07459">
        <property type="protein sequence ID" value="KVI07459"/>
        <property type="gene ID" value="Ccrd_014164"/>
    </dbReference>
    <dbReference type="OMA" id="AWSVIFS"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF36">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="186"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="519" mass="59099" checksum="4DA6901EC1A84AAA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEB9</accession>
    <name>A0A103YEB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_014075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YEB9"/>
    <dbReference type="Gramene" id="KVI07541">
        <property type="protein sequence ID" value="KVI07541"/>
        <property type="gene ID" value="Ccrd_014075"/>
    </dbReference>
    <dbReference type="OMA" id="VWNALIQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031425">
        <property type="term" value="P:chloroplast RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF26">
        <property type="entry name" value="CHLOROPLAST RNA SPLICING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="816"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="921"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="956"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1131"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1453" mass="164775" checksum="0A715FF7FC83F5E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFB4</accession>
    <name>A0A103YFB4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001382">
        <property type="protein sequence ID" value="KVI08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFB4"/>
    <dbReference type="Gramene" id="KVI08035">
        <property type="protein sequence ID" value="KVI08035"/>
        <property type="gene ID" value="Ccrd_013598"/>
    </dbReference>
    <dbReference type="OMA" id="DIMAYWF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040273">
        <property type="entry name" value="PIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245:SF4">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119655" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="72" mass="7666" checksum="AFBFFF1E10F5BA27" modified="2016-04-13" version="1">MAFKKTCTLLVLVVILIAVMSLVVVDGRALSEDFAGANHLATYSSVYAKAKKGMCFWLQQLASGPSPRGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFI4</accession>
    <name>A0A103YFI4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001228">
        <property type="protein sequence ID" value="KVI08154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFI4"/>
    <dbReference type="STRING" id="59895.A0A103YFI4"/>
    <dbReference type="Gramene" id="KVI08154">
        <property type="protein sequence ID" value="KVI08154"/>
        <property type="gene ID" value="Ccrd_013477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119669" evidence="3">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="15289" checksum="A17DF52CCE9E9825" modified="2016-04-13" version="1" fragment="single">LLGLDLFTQSLHLLLIFEVLCRFCAAVEAKYPALLFKQQLTTFLEKIYGLIRDNLKKEISLLIGSCIQVSRTSRAIFFNNLPSGSVIFDARCGNGKYLGLNPDYVFIGCDISAPLIQICNDRGHEVLVADAVNLPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFZ0</accession>
    <name>A0A103YFZ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001125">
        <property type="protein sequence ID" value="KVI08397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFZ0"/>
    <dbReference type="STRING" id="59895.A0A103YFZ0"/>
    <dbReference type="Gramene" id="KVI08397">
        <property type="protein sequence ID" value="KVI08397"/>
        <property type="gene ID" value="Ccrd_013230"/>
    </dbReference>
    <dbReference type="OMA" id="FPADSCE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009739">
        <property type="term" value="P:response to gibberellin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010090">
        <property type="term" value="P:trichome morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044291">
        <property type="entry name" value="GIS/GIS2/ZFP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46547">
        <property type="entry name" value="ZINC FINGER PROTEIN GIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46547:SF7">
        <property type="entry name" value="ZINC FINGER PROTEIN GIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="293" mass="33309" checksum="502A20F507378CA4" modified="2016-04-13" version="1">MERNDTETHDFMNVESFSQLPFIRPSPLKEKSIRLFGKEFSGAAGADSPEVIISDDADSNETAAVESKDAGESNRKFECNYCCRNFPTSQALGGHQNAHKRERQHAKRAHLQSTMVHGSFSEAQMYGLMNYHRFAPSTTPPPPYFHHTNTASSITNYNNRFYGGTSSYTSHQTPINGSPLAMWKFPTTTTTTTFSDNPKSSIIGTGNHSQIRYTYEQKPNVQEQWKSKLEIESSERKVKGQIPRKELLEPKEGDRFGKTNHMNEIDLEIDMERRITGTRSIWVKFCGISFCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH80</accession>
    <name>A0A103YH80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001074">
        <property type="protein sequence ID" value="KVI09041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH80"/>
    <dbReference type="Gramene" id="KVI09041">
        <property type="protein sequence ID" value="KVI09041"/>
        <property type="gene ID" value="Ccrd_012597"/>
    </dbReference>
    <dbReference type="OMA" id="PNKFMYN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000690">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000470">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g66520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000348">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF528">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="666" mass="75037" checksum="CE09E6D67CDF13E2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHP3</accession>
    <name>A0A103YHP3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_012320</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; prenylquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001066">
        <property type="protein sequence ID" value="KVI09294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHP3"/>
    <dbReference type="STRING" id="59895.A0A103YHP3"/>
    <dbReference type="Gramene" id="KVI09294">
        <property type="protein sequence ID" value="KVI09294"/>
        <property type="gene ID" value="Ccrd_012320"/>
    </dbReference>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000013">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000025">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="17">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="17">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI09294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="441" mass="48455" checksum="F7BAA205846D8EED" modified="2016-04-13" version="1">MGTEAMLTNGSTAAGSTFKLVGFKNFTRVNPMSDKFSVKRFHHVEFWCSDATNTARRFSWGLGMPIVLKSDLSTGNATHASYLLRSGQLNFLFTAPYSPSISTNTSTSTASIPTFSHTDCRNFTASHGLAVRSIAIEVEDAEIAFSVSVSHGAKPSTSPITLGNNDAVLSEVKLYGDVVLRYISYKNPNYDALSSFLPGFEPVEKTSTFLDLDYGIRRLDHAVGNVPELAPAVDYVKSFTGFHEFAEFTAEDVGTSESGLNSVVLACNSEMVLLPMNEPVYGTKRKSQIQTYLEHNEGAGVQHLALASEDIFRSLREMRKRSGVGGFEFMPSPPPTYYRNLKKRAGDVLSDEQIKECEELGILVDRDDQGTLLQIFTKPVGDRPTIFIEIIQRVGCMMKDDDGKVQQKAGCGGFGKGNFSELFKSIEEYEKTLESRSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIS4</accession>
    <name>A0A103YIS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI09896">
        <property type="protein sequence ID" value="KVI09896"/>
        <property type="gene ID" value="Ccrd_011716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="19849" checksum="3B4BC402DCCC6679" modified="2016-04-13" version="1" fragment="single">MDRNHLVAVVSILNVYIQMLVCLFSLTIWLIELENRNSKRETLGQRTFTXRQIRSTKIQRITRESDVSYINELRVDRNVFENMSMENDDDRNVPPIPSPFNTTSHSSIPNKEEGTSKKRKRTNEISKLLEKIKNGIHEATNQMKGLASVISDSTTEMDGLSDELKRLGLGVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM70</accession>
    <name>A0A103YM70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000058">
        <property type="protein sequence ID" value="KVI11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM70"/>
    <dbReference type="Gramene" id="KVI11676">
        <property type="protein sequence ID" value="KVI11676"/>
        <property type="gene ID" value="Ccrd_009911"/>
    </dbReference>
    <dbReference type="OMA" id="LVCAIWY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="571" mass="62334" checksum="010820E325ECC0EF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM81</accession>
    <name>A0A103YM81_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-acyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_009899</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01000053">
        <property type="protein sequence ID" value="KVI11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM81"/>
    <dbReference type="STRING" id="59895.A0A103YM81"/>
    <dbReference type="Gramene" id="KVI11689">
        <property type="protein sequence ID" value="KVI11689"/>
        <property type="gene ID" value="Ccrd_009899"/>
    </dbReference>
    <dbReference type="OMA" id="RECQSHS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000300">
        <property type="entry name" value="S-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000334">
        <property type="entry name" value="S-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF17">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="377"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="607" mass="66734" checksum="2BDC6427BC3E986F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNG2</accession>
    <name>A0A103YNG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L31e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNG2"/>
    <dbReference type="STRING" id="59895.A0A103YNG2"/>
    <dbReference type="Gramene" id="KVI12278">
        <property type="protein sequence ID" value="KVI12278"/>
        <property type="gene ID" value="Ccrd_009332"/>
    </dbReference>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF52">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL31X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13909" checksum="0B9C5AC50D6FD351" modified="2016-04-13" version="1">MVEKTKGRKEEVVTREYTINLHKRLHGCTFKKKAPKAIKEIRKFAQKTMGTTDVRVDVKLNKYVWSRGIRSVPRRVRVRIARKRNDDEDAKEELYSLVTVAEIPAEGLKGLGTKIIDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118HVQ6</accession>
    <name>A0A118HVQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007757">
        <property type="protein sequence ID" value="KVG70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118HVQ6"/>
    <dbReference type="Gramene" id="KVG70788">
        <property type="protein sequence ID" value="KVG70788"/>
        <property type="gene ID" value="Ccrd_026253"/>
    </dbReference>
    <dbReference type="OMA" id="YIYRWRE"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25895" checksum="8BF28CE69B870FEE" modified="2016-04-13" version="1">MDQIKHTYVQVDGLKLHVAEIGSESAPPVLFFHGFPEISYTWCHQMIAVANAGYRAIAPDYRGYGLSDIPAEPEKTSFADLIADTATILDSLAISKVFVIGKDFGSMVGYLFALFFPEKLAGIITLGIPYMPPEALQQLQTLPEGFYMRRWQEPGRAEADFDRFDAKTVVRKIYILFSRSEVPIAXENQEVLDLVEPSAPLPSWFTEEDLETYGAXYTKSGFLTALQVPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118IBM5</accession>
    <name>A0A118IBM5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_026010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADAGIO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007258">
        <property type="protein sequence ID" value="KVH01646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118IBM5"/>
    <dbReference type="STRING" id="59895.A0A118IBM5"/>
    <dbReference type="Gramene" id="KVH01646">
        <property type="protein sequence ID" value="KVH01646"/>
        <property type="gene ID" value="Ccrd_026010"/>
    </dbReference>
    <dbReference type="OMA" id="REICGIF"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22154">
        <property type="entry name" value="F-box_AtADO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000021">
        <property type="entry name" value="Adagio protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000041">
        <property type="entry name" value="Adagio protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000005">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000062">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175:SF5">
        <property type="entry name" value="ADAGIO PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="17">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH01646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="66172" checksum="D7C3D505884AA98B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTB5</accession>
    <name>A0A118JTB5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTB5"/>
    <dbReference type="STRING" id="59895.A0A118JTB5"/>
    <dbReference type="Gramene" id="KVH90504">
        <property type="protein sequence ID" value="KVH90504"/>
        <property type="gene ID" value="Ccrd_007531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF593">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24317" checksum="48C9B3C2A83272DD" modified="2016-04-13" version="1">MDRIMEWNSGNPSSRPFIPRSAPQSSFAFLYNYNNDHYVYPPGVGEMKHQMMQGAVPAGALAMMEMNANEYDNNNQEKKKRLSSEQLEALENTFQEEKKLDPDTKMKLAHELGLQPRQIAVLALRTILKEQVSKRQGAGSSTGYTYISGEETVESTSVATIRTTTNHHPHQLTLGGQHATTTTAAAAAMDCNYVLNYDPATSMPPTPSYSNWAVLPTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUC9</accession>
    <name>A0A118JUC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_006146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUC9"/>
    <dbReference type="Gramene" id="KVH91839">
        <property type="protein sequence ID" value="KVH91839"/>
        <property type="gene ID" value="Ccrd_006146"/>
    </dbReference>
    <dbReference type="OMA" id="FFEGCHY"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000234">
        <property type="entry name" value="Probable inactive receptor kinase RLK902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF6">
        <property type="entry name" value="OS01G0223600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159683" evidence="13">
        <location>
            <begin position="19"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="322"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH91839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="619" mass="68200" checksum="62465ABA988EABFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV13</accession>
    <name>A0A118JV13_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_005406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004813">
        <property type="protein sequence ID" value="KVH92577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV13"/>
    <dbReference type="STRING" id="59895.A0A118JV13"/>
    <dbReference type="Gramene" id="KVH92577">
        <property type="protein sequence ID" value="KVH92577"/>
        <property type="gene ID" value="Ccrd_005406"/>
    </dbReference>
    <dbReference type="OMA" id="ISWWIEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF541">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="109"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="471" mass="52851" checksum="5A5AC98032F06B3A" modified="2016-04-13" version="1" fragment="single">ECLFLPLLFNRPFFCKIKSHRPYHPYTTYSPWSVIYSITASGATIYPAYLSIIPHTTFKINSGGRRSRTGFRVLIHSLLSSSSNSVCWCRESEREREREKRKMVNPRCYLDISIGGELEGRLVVELYKDVVPKTAENFRALCTGEKGIGPNTGVPLHLKGSCFHRVIKGFMIQGGDISARNGTGGESIFGMKFEDENFELKHERKGMLSMANSGPNTNGSQFFVTTTRTPHLDGKHVVFGRVIKGMGVVRSVEHTTTGENDVPTLDVIIEDCGEIPEGADDGVCDFFKDGDTYPDWPLDLDVKPEEISWWITAKQDYKNALRKYRKALRYLDVCWEKEDIDEGKTDSLRKTKSQIFTNSSACKLKLGDLKGALLDADFALREMDDNVKALYRQGQVGNCTCVASMALNDIDSAVESFKKALVLEPNDGGIKKELAAAKKKASFIFAPARFCKPQVRLFPALWEIFETTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV92</accession>
    <name>A0A118JV92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calmodulin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant ACBP60 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004617">
        <property type="protein sequence ID" value="KVH93712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV92"/>
    <dbReference type="STRING" id="59895.A0A118JV92"/>
    <dbReference type="Gramene" id="KVH93712">
        <property type="protein sequence ID" value="KVH93712"/>
        <property type="gene ID" value="Ccrd_004239"/>
    </dbReference>
    <dbReference type="OMA" id="RQTVQCH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046829">
        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF51">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN 60 E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="10">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein C-terminal" evidence="11">
        <location>
            <begin position="283"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="57081" checksum="6EB42E99A3F56F01" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVD7</accession>
    <name>A0A118JVD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004755">
        <property type="protein sequence ID" value="KVH93506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVD7"/>
    <dbReference type="STRING" id="59895.A0A118JVD7"/>
    <dbReference type="Gramene" id="KVH93506">
        <property type="protein sequence ID" value="KVH93506"/>
        <property type="gene ID" value="Ccrd_004440"/>
    </dbReference>
    <dbReference type="OMA" id="GHIWCVG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000373">
        <property type="term" value="P:Group II intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37763">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37763:SF1">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="425" mass="48871" checksum="397E3B3BF1835376" modified="2016-04-13" version="1">MFVQSFGVIRQINRHVRNHFHVPNPLRINKLTGVVHLYAKSYHSLTEPQLDDHLSFEWCERAFPKLIKLTQLLNGFDLINGRLVNVHNKCVVTDEFLMQSMHTFKSLGTAFLWSPSMQQTLCTAKSPSICVNKPIYRKPIAVNSLKKVCDILEVSAQQRKLVRLAICPQITQHQIWMAALGEILNQLKYEMGVKDYGCTTKGDNMGQQIVVNCLGFLDDAVAYDPDSTSWMRLAPKRDADSPPPAKWADFLEMFNDLTKILKNDQEFLFYVAKLEIMKEGLLQIKDVLVDKNIGYKEARHQEHLVQKKLTKSLGHSSQCLFTLLLYYLYGDIRDIELDMCCWFSADVGGNKFYLCVGKILTSDGEKMLRHAVKQLDRVLGVIKFVHEMAEMEEILELQGHLWCIDSENRSLTYRGHKFFIHGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVQ7</accession>
    <name>A0A118JVQ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallophosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004802">
        <property type="protein sequence ID" value="KVH92890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVQ7"/>
    <dbReference type="STRING" id="59895.A0A118JVQ7"/>
    <dbReference type="Gramene" id="KVH92890">
        <property type="protein sequence ID" value="KVH92890"/>
        <property type="gene ID" value="Ccrd_005065"/>
    </dbReference>
    <dbReference type="OMA" id="LHCMKYP"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07384">
        <property type="entry name" value="MPP_Cdc1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000050">
        <property type="entry name" value="Calcineurin-like metallo-phosphoesterase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159735" evidence="6">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="531" mass="60052" checksum="C193D019E59FF77A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX31</accession>
    <name>A0A118JX31_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="7">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Probably involved in membrane trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
            <location evidence="7">Secretory vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004268">
        <property type="protein sequence ID" value="KVH96579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX31"/>
    <dbReference type="STRING" id="59895.A0A118JX31"/>
    <dbReference type="Gramene" id="KVH96579">
        <property type="protein sequence ID" value="KVH96579"/>
        <property type="gene ID" value="Ccrd_001328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF76">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="209" mass="23903" checksum="126F6D9B6C04E733" modified="2016-04-13" version="1">MGSTYDSNPFDGEEPDTFANSRPEPADYGGGSKDDVPLNSTNDLRAKEKELEAKEAELNRREEELKRKEDAIARARIFQEEKNWPPFFPLIHHDIPKEIPLHQQRTQYVAFTTLLGIVVCLIWNLVAVTVAWIAGEVSYSLLPICFYCSSYDLQGEISYCFYFVGFAFFAIESTISIYVIQQVYRYFRGSGKAQEVKRDAKRSTTMVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY23</accession>
    <name>A0A118JY23_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01004318">
        <property type="protein sequence ID" value="KVH96400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY23"/>
    <dbReference type="STRING" id="59895.A0A118JY23"/>
    <dbReference type="Gramene" id="KVH96400">
        <property type="protein sequence ID" value="KVH96400"/>
        <property type="gene ID" value="Ccrd_001511"/>
    </dbReference>
    <dbReference type="OMA" id="IGCIDSM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000003">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="248"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="43443" checksum="5E5D78238B5F0DFC" modified="2016-04-13" version="1">MATKKLYENFSKSLIDEVHKWGAMKQTGVSLRYMLDFGSVPSDRNLIIAAQFLHKELPIRIARRAIELQSLPYGLSEKPAVLKVRDWYLDSFRDLRSFPEIKDITDERDFTQMIKLIKVRHNNVVPTMALGVKQLKKGLDPKVEDEGLDEIHQFLDRFYMSRIGIRMLIDVKTCFCAFKFGSNSGQHVAVHDPNPPPNCIGYIHAKMSPMQVAKDASEDARSICLREYGSAPDINIYGDPSFAFPYVPTHLHMMVFELVKNSLRAVQERYMDSEKVPPPIRIIVADGAEDVTIKACVSDEGGGIARSGLPKIFTYLYSTANNPLYEQSNLGAVDTVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYE8</accession>
    <name>A0A118JYE8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003910">
        <property type="protein sequence ID" value="KVH96985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYE8"/>
    <dbReference type="STRING" id="59895.A0A118JYE8"/>
    <dbReference type="Gramene" id="KVH96985">
        <property type="protein sequence ID" value="KVH96985"/>
        <property type="gene ID" value="Ccrd_000924"/>
    </dbReference>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH96985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="93" mass="10526" checksum="F9B31A7F42428EE5" modified="2016-04-13" version="1">MGKRKSRAKPPPKKRMDKLDTVFSCPFCNHGTSVECRIDMKNLIGEASCRICQENFSTTITALTEPIDIYSEWIDECERVNALDDDGVPVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYT9</accession>
    <name>A0A118JYT9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine-rich repeat, cysteine-containing subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYT9"/>
    <dbReference type="STRING" id="59895.A0A118JYT9"/>
    <dbReference type="Gramene" id="KVH99067">
        <property type="protein sequence ID" value="KVH99067"/>
        <property type="gene ID" value="Ccrd_022699"/>
    </dbReference>
    <dbReference type="OMA" id="INCIISP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000690">
        <property type="entry name" value="F-box/LRR-repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001151">
        <property type="entry name" value="F-box/LRR-repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF182">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="48071" checksum="603D0669BF2EFAB4" modified="2016-04-13" version="1" fragment="single">MIDHVESSEFVSSFYKRFHNLDNEQRKYLRVGCGLNPANEALTSLCHRFPNLNNVEITYSGWMSKLGKQLEDPGLCVLSETCPFLTDLTLSYCTFITDAGLSCLASCSKLSSLKLNFTPRITGCGIFSIVVGCKNLKVLHLIRCLNVSNLEWLECLGRLETLEDLCVKNCRGIGEGALIKLGPTWRNIKRLQFEVDANYRYMKLYDRLAVDRWQKQWVPCESIVELSLINCIISPGRGLACILDKCKNLEKIHLDMCIGARDCDIIGLAKNSRNLRSISIRVPSDFSLPLLMENPLRLTDESLKAVAQNCTLLESVSLSFSDGEFLSLSSFSLDGILSLIKMCPLKELSLDRVCSFNNIGMEALCSADHLQTLELSGCQEISDEGLELLAHYPRLRVLRLMKCLGVTDDGFKPFIGSGKLEVLVVNDCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ44</accession>
    <name>A0A118JZ44_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003643">
        <property type="protein sequence ID" value="KVH98862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ44"/>
    <dbReference type="Gramene" id="KVH98862">
        <property type="protein sequence ID" value="KVH98862"/>
        <property type="gene ID" value="Ccrd_022905"/>
    </dbReference>
    <dbReference type="OMA" id="WALANWF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16276" checksum="D53B7A676D0E0511" modified="2016-04-13" version="1">MAKIGLFDLEKHFAFYGAYHSNPVNVFIHMLFVWPILFTSLVILYFTPPLVDLSLPYSLIMNYGFFFTVIYAGFYVSLDVKAGSLAGFLCFLCWVFGSFLAHHLGFSLAWKVIMRSGLSTMVIPAKVDAGIQEWKEKKQKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1R5</accession>
    <name>A0A118K1R5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETICULATA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002399">
        <property type="protein sequence ID" value="KVI03240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1R5"/>
    <dbReference type="STRING" id="59895.A0A118K1R5"/>
    <dbReference type="Gramene" id="KVI03240">
        <property type="protein sequence ID" value="KVI03240"/>
        <property type="gene ID" value="Ccrd_018463"/>
    </dbReference>
    <dbReference type="OMA" id="ACPASHM"/>
    <dbReference type="OrthoDB" id="497268at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021825">
        <property type="entry name" value="RETICULATA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620:SF15">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11891">
        <property type="entry name" value="RETICULATA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="358" mass="37953" checksum="011FFAC441ADD2A7" modified="2016-04-13" version="1">MASVAQLHYSPLAENNRHLNPARHIPSFQLPNFTCKKLVLNSSQNFPCSSFRSRPINPDLLSNQQPNTCAGGGGGGSGVGHGSGGGGDGGSSDWNGGGKSDDSSSLDSFGPIGAFLSGWRSRVAADPQFPFKVLMEEVVGVSACVLGDMASRPNFGLNELDFVFSTLVVGSIMNFTLMYLLATTMTSASATLPFIFANSPTSHMFEPGAYSLMNRVGTFVYKGTVFAAVGFAAGLVGTALSNGLIKMRKKMDPSFESPNKPPPTVLNAFTWAIHMGLSSNFRYQTLNGIEFVLAKGLPPLAFKSSVVGLRLVNNVLGGMSFVILARMTGSQSSGEEKKIGDEEVSEEKMKLLNEIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1T7</accession>
    <name>A0A118K1T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_018420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002386">
        <property type="protein sequence ID" value="KVI03283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1T7"/>
    <dbReference type="Gramene" id="KVI03283">
        <property type="protein sequence ID" value="KVI03283"/>
        <property type="gene ID" value="Ccrd_018420"/>
    </dbReference>
    <dbReference type="OMA" id="HENTEYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="5">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI03283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="492" mass="56609" checksum="5F9C7E2C7EDD1088" modified="2016-04-13" version="1">MDPISFNETFVKDIFDEIDGINGKRKGVVHDREFTTVTNDDVKYKPKVGDSFESVESAEKMYRKYANEVGFDVRLSNKKINKLGRITSQFYVCSKEGRPKVSGRTIRNSNIKRSGCGACLKIHLVKEPNQYEVYKFVEQHNHILFNKEEMRFSRSKRQLHYADHKNVFHGSSSKVGVTKSHRFIKAVKGGVDSSGGTVRDHQNFKRDMTYFVGNKDAQMLLNVMANRRKVTTKSTIPRLVSPCKLEAHAAEVYTRTIFFEIQKELRKAVWLCGWDGFTDIGETRVYIITHKNKASKVTTKYTVIKNKMENSYDCSCNCFVRNGISCRHALKVMLNDEVDKIPDKYILRRWRRDLVPVEWLPAHFRYGEVDAEKERLMSLAYSYFERILGRVQNEKDILSRFVDQLVDIELPLQSHTEETTSSIKEFLGVSQPETVDVLPPTGIRNKGCGTGKRLISAAEKAIPNGKKQNKKCRLCGQMATHDSRNCPKRDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2I6</accession>
    <name>A0A118K2I6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_017273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002119">
        <property type="protein sequence ID" value="KVI04413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2I6"/>
    <dbReference type="STRING" id="59895.A0A118K2I6"/>
    <dbReference type="Gramene" id="KVI04413">
        <property type="protein sequence ID" value="KVI04413"/>
        <property type="gene ID" value="Ccrd_017273"/>
    </dbReference>
    <dbReference type="OMA" id="DASIACH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF98">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="42"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="545" mass="60673" checksum="3D5F487F3FAD0F40" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2K0</accession>
    <name>A0A118K2K0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_017224</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002049">
        <property type="protein sequence ID" value="KVI04457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2K0"/>
    <dbReference type="STRING" id="59895.A0A118K2K0"/>
    <dbReference type="Gramene" id="KVI04457">
        <property type="protein sequence ID" value="KVI04457"/>
        <property type="gene ID" value="Ccrd_017224"/>
    </dbReference>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="668" mass="77406" checksum="2A8936BE980AB00D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K338</accession>
    <name>A0A118K338_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001878">
        <property type="protein sequence ID" value="KVI05325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K338"/>
    <dbReference type="STRING" id="59895.A0A118K338"/>
    <dbReference type="Gramene" id="KVI05325">
        <property type="protein sequence ID" value="KVI05325"/>
        <property type="gene ID" value="Ccrd_016345"/>
    </dbReference>
    <dbReference type="OMA" id="EMFENGF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF16">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="828" mass="92682" checksum="BE87C1C04344AF6A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K391</accession>
    <name>A0A118K391_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_016073</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K391"/>
    <dbReference type="Gramene" id="KVI05567">
        <property type="protein sequence ID" value="KVI05567"/>
        <property type="gene ID" value="Ccrd_016073"/>
    </dbReference>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <location>
            <begin position="401"/>
            <end position="424"/>
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        <location>
            <begin position="448"/>
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            <begin position="182"/>
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            <begin position="9"/>
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            <position position="541"/>
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            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI05567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1341" mass="151829" checksum="BD2FF702990F5461" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3H7</accession>
    <name>A0A118K3H7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3H7"/>
    <dbReference type="Gramene" id="KVI05970">
        <property type="protein sequence ID" value="KVI05970"/>
        <property type="gene ID" value="Ccrd_015662"/>
    </dbReference>
    <dbReference type="OMA" id="WLQDDEI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35105">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35105:SF7">
        <property type="entry name" value="PROTEIN CDI-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38986" checksum="590C315051C57174" modified="2016-04-13" version="1">MMMEMYCAKRSDQIDAGSKCNKTIVEGLSGTYNQNENQYIRLYLDAFLDPSTRFRQSRSTIFVFFLRTDLLLAMSVESLKTSNIVNGDSNFSNGHTKKPCRIYVGYDPREDVAYEVCRYSIMKRSSIPVEIIPIKQSELREKNYFWRERGKLESTEFSFTRFLTPFLAGYEGWAMFVDCDFLYLGDIKELFDLIDDKYAVMCVQHDYTPKETTKMDGAVQTVYPRKNWSSMVLYNCGHPKNKVLTPEVVNKESGAFLHRFQWLEDHEIGSVPFVWNFLVGHNRVEKGDPNSYPKAIHYTLGGPWFEAWKDCEFGDLWLNELEECEIAKKVEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3U6</accession>
    <name>A0A118K3U6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_015184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001824">
        <property type="protein sequence ID" value="KVI06467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3U6"/>
    <dbReference type="STRING" id="59895.A0A118K3U6"/>
    <dbReference type="Gramene" id="KVI06467">
        <property type="protein sequence ID" value="KVI06467"/>
        <property type="gene ID" value="Ccrd_015184"/>
    </dbReference>
    <dbReference type="OMA" id="NISYYTQ"/>
    <dbReference type="OrthoDB" id="1874781at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF75">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI06467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="523" mass="59815" checksum="43DB0B188C0657DD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4B2</accession>
    <name>A0A118K4B2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4B2"/>
    <dbReference type="Gramene" id="KVI07275">
        <property type="protein sequence ID" value="KVI07275"/>
        <property type="gene ID" value="Ccrd_014325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11677" checksum="CF2BD392BE5CE679" modified="2016-04-13" version="1">MNRSDRNFEGIARQPEAEGKIRAKVRLLDVRLAGDINISIAGRWWWFMLKFHRCRFRRSISTLCFTSRWFPWIPGWWLTVVFPIHSTAVSFVGERLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5R0</accession>
    <name>A0A118K5R0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">glutamate carboxypeptidase II</fullName>
            <ecNumber evidence="15">3.4.17.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_012155</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.</text>
            <dbReference type="EC" id="3.4.17.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01001061">
        <property type="protein sequence ID" value="KVI09465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5R0"/>
    <dbReference type="STRING" id="59895.A0A118K5R0"/>
    <dbReference type="Gramene" id="KVI09465">
        <property type="protein sequence ID" value="KVI09465"/>
        <property type="gene ID" value="Ccrd_012155"/>
    </dbReference>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010075">
        <property type="term" value="P:regulation of meristem growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000164">
        <property type="entry name" value="Os01g0740650 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF75">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE AMP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="331"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="578"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI09465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="703" mass="77494" checksum="0AB40BBD025CE7EC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K628</accession>
    <name>A0A118K628_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the production of high-mannose type N-glycans during plant development and fruit maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(4)-(oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:73067"/>
            <dbReference type="Rhea" id="RHEA-COMP:12603"/>
            <dbReference type="Rhea" id="RHEA-COMP:18176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:132248"/>
            <dbReference type="ChEBI" id="CHEBI:192714"/>
            <dbReference type="ChEBI" id="CHEBI:192715"/>
            <dbReference type="EC" id="3.2.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K628"/>
    <dbReference type="STRING" id="59895.A0A118K628"/>
    <dbReference type="Gramene" id="KVI10003">
        <property type="protein sequence ID" value="KVI10003"/>
        <property type="gene ID" value="Ccrd_011630"/>
    </dbReference>
    <dbReference type="OMA" id="WGVLQSY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06547">
        <property type="entry name" value="GH85_ENGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000043">
        <property type="entry name" value="cytosolic endo-beta-N-acetylglucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057882">
        <property type="entry name" value="ENGase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25529">
        <property type="entry name" value="Ig_ENGASE1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="9">
        <location>
            <begin position="122"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase C-terminal" evidence="10">
        <location>
            <begin position="570"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="683" mass="77122" checksum="A3FC83B03C9ECD2A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K679</accession>
    <name>A0A118K679_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001026">
        <property type="protein sequence ID" value="KVI10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K679"/>
    <dbReference type="STRING" id="59895.A0A118K679"/>
    <dbReference type="Gramene" id="KVI10217">
        <property type="protein sequence ID" value="KVI10217"/>
        <property type="gene ID" value="Ccrd_011381"/>
    </dbReference>
    <dbReference type="OMA" id="CIRVIGK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47747">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P38-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47747:SF2">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P38-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="947" mass="109401" checksum="B38E6FCE109235C9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7F3</accession>
    <name>A0A118K7F3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7F3"/>
    <dbReference type="STRING" id="59895.A0A118K7F3"/>
    <dbReference type="Gramene" id="KVI12148">
        <property type="protein sequence ID" value="KVI12148"/>
        <property type="gene ID" value="Ccrd_009488"/>
    </dbReference>
    <dbReference type="OMA" id="HWESLAN"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="274" mass="30079" checksum="8E9D6B9030E37582" modified="2016-04-13" version="1">MAERGGERGGFGRGFGDRGRGRGGDRGRGRRRGGRRDADEEKWVPVTKLGRLVKDGKITKLEEVYLHSLPIKEHQIIDQILPSLKDEVMKIMPVQKQTRAGQRTRFKAFVVVGDGNGHVGLGVKCSKEVATAIRGAIILAKLSVIPVRRGYWGNKIGKPHTVPCKVTGKCGSVTVRLVPAPRGAGIVAARVPKKVLQFAGIDDVFTSSRGSTKTLGNFVKATFDCLLKTYGFLTPDFWRETRFSRSPFQEYTDMLAKPTTKAITYVEDVADIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7K5</accession>
    <name>A0A118K7K5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000005">
        <property type="protein sequence ID" value="KVI12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7K5"/>
    <dbReference type="STRING" id="59895.A0A118K7K5"/>
    <dbReference type="Gramene" id="KVI12378">
        <property type="protein sequence ID" value="KVI12378"/>
        <property type="gene ID" value="Ccrd_009201"/>
    </dbReference>
    <dbReference type="OMA" id="ENTGERN"/>
    <dbReference type="OrthoDB" id="10038011at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF374">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16293" checksum="048C55A4533FAE1F" modified="2016-04-13" version="1">MNRGGASRGNHNDSRTTGGPTEEVIKYRGVRRRPWGKFAAEIRDPNRQGTRVWLGTYATAEEAARAYDRAAFDMRGHMAVLNFPSEYPPTFSAAAYNASSAMSAASSAAESSSGSTTAAHGREVFEFEYLDDQLLEDLLDYDNNKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEW1</accession>
    <name>A0A124SEW1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003110">
        <property type="protein sequence ID" value="KVI01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEW1"/>
    <dbReference type="STRING" id="59895.A0A124SEW1"/>
    <dbReference type="Gramene" id="KVI01366">
        <property type="protein sequence ID" value="KVI01366"/>
        <property type="gene ID" value="Ccrd_020351"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937164at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057209">
        <property type="entry name" value="DUF7887"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38389">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38389:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25397">
        <property type="entry name" value="DUF7887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7887" evidence="2">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="13272" checksum="A98ED0EA9D581F84" modified="2016-04-13" version="1">MVTTQKCVVGISLSTTLFSSISMVNNNMNEGGRRRRRRRSKTSCISMAKKDDKYPLKIVSQAAVVVLGLGFIDAGYSGDWSRIGVISKENEDLLKAAAFIVVPLCIFLIFSISKPNHDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGR1</accession>
    <name>A0A124SGR1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase inhibitor 2 (IPP-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001515">
        <property type="protein sequence ID" value="KVI07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SGR1"/>
    <dbReference type="Gramene" id="KVI07173">
        <property type="protein sequence ID" value="KVI07173"/>
        <property type="gene ID" value="Ccrd_014466"/>
    </dbReference>
    <dbReference type="OMA" id="FWTDPCI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="991" mass="108816" checksum="566276CD78E7745D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGS1</accession>
    <name>A0A124SGS1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGS1"/>
    <dbReference type="STRING" id="59895.A0A124SGS1"/>
    <dbReference type="Gramene" id="KVI07261">
        <property type="protein sequence ID" value="KVI07261"/>
        <property type="gene ID" value="Ccrd_014365"/>
    </dbReference>
    <dbReference type="OMA" id="VGWLETL"/>
    <dbReference type="OrthoDB" id="1919674at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33448">
        <property type="entry name" value="CHLOROPLAST PROTEIN HCF243-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33448:SF3">
        <property type="entry name" value="OS09G0370000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="38420" checksum="E7C5DD33DD9B334A" modified="2016-04-13" version="1">MSRREGKGPPSRDLLVCFPTRAHLTLMPKAVSSPRRHHQNHLRKSMRGGGGGHASPYLKQMSSENLSEPTSPKVTCAGQIKVRPRAGACKNWQTVMEEIERLHINRKTKKPNWVEALGFKKEVMQFLACLRRIKFDFRCMRSFSHVDVTSDDEEGDNDKEIDQNQDIQDHYDHEEVSSRTVFSKWFMVLQENNQDCGVFSKDEKSLTSEETDQDPRPCLPPANALLLMRCRSAPAKSWMEEKQEEEEQEKEDDDDDGHDEKVEEEEHADDDDGDDDEKMEKKEKKRKSLMELMKINDQSDFYKLSSDVVKETWVIGGIQKDPFSRSRSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHN9</accession>
    <name>A0A124SHN9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHN9"/>
    <dbReference type="STRING" id="59895.A0A124SHN9"/>
    <dbReference type="Gramene" id="KVI10141">
        <property type="protein sequence ID" value="KVI10141"/>
        <property type="gene ID" value="Ccrd_011497"/>
    </dbReference>
    <dbReference type="OMA" id="FHDHLHM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051871">
        <property type="entry name" value="GMC_Oxidoreductase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968:SF31">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE (GMC) OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968">
        <property type="entry name" value="OSJNBA0019K04.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176276" evidence="8">
        <location>
            <begin position="28"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="503"/>
            <end position="504"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="543"/>
            <end position="544"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="440"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="551" mass="59953" checksum="28D3A9294606B03F" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHW9</accession>
    <name>A0A124SHW9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_010721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000987">
        <property type="protein sequence ID" value="KVI10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHW9"/>
    <dbReference type="Gramene" id="KVI10876">
        <property type="protein sequence ID" value="KVI10876"/>
        <property type="gene ID" value="Ccrd_010721"/>
    </dbReference>
    <dbReference type="OMA" id="RWIVYPA"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="737" mass="82960" checksum="A69DE4ACAEC30565" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI34</accession>
    <name>A0A124SI34_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_010142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000121">
        <property type="protein sequence ID" value="KVI11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI34"/>
    <dbReference type="STRING" id="59895.A0A124SI34"/>
    <dbReference type="Gramene" id="KVI11448">
        <property type="protein sequence ID" value="KVI11448"/>
        <property type="gene ID" value="Ccrd_010142"/>
    </dbReference>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase 4 peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A oxidase 4, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045008">
        <property type="entry name" value="ACX4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43188:SF1">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43188">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="157"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="267"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="46589" checksum="E40F021E47980251" modified="2016-04-13" version="1">MTIQSSKPQDDQSKDSKSSYFNLPALDVSVAFPQATPVSVFPPCTSDFYHFDDLLTPAEQALRLRVRECVEREVAPIMTKLGALNIAGGTIKGYGCPGLSVTANAIVTAELARVDASCSTFILVHSSLGMLTISLCGSEIQKQKYLPSLAKLNTIACWGLTEPDYGSDASGLRTTATKVDGGWVLEGQKRWIGNSTFADILIIFAKNKDTNQINGFIVKKNAPGLQATKIENKIGLRMVQNGDILLQKVFVPDEDRLPGVNSFQDTSKVLAVSRVMVAWQPIGITMGVYDMCHRYLLERKQFGAPLAAFQINQQKLVQMLANIQAMFLMGWRLCKLYEAGKMTPGQASLGKSWISLRARETVALGRELLGGNGILSDFLVAKAFGDLEPIYTYEGTYDINTLVTGREITGIASFKPVVKKPQMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103N0J8</accession>
    <name>A0A103N0J8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008740">
        <property type="protein sequence ID" value="KVG03581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103N0J8"/>
    <dbReference type="Gramene" id="KVG03581">
        <property type="protein sequence ID" value="KVG03581"/>
        <property type="gene ID" value="Ccrd_026585"/>
    </dbReference>
    <dbReference type="OMA" id="HAHGHQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVG03581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="34721" checksum="24A12B513F18BB60" modified="2016-04-13" version="1">MSTTSCSDSPDSDPCRDDKTALILKFVAIAAILLAGIIGVAIPLVGKXWRFLRTDSNLFFATKAFAAGVILATGFVHMLPDATEALTNPCLPETPWSQFPFAGFIAMMAALVTLLADFVSTQYYESKQQVKQIQDVRVDSVDSGSEFLIGPMAVDEKVFGEEGGGGIHIVGMHAHVLELGIVSHSIMIGLSLGVSQSPCTIRPLLGALSFHQFFEGFALGGCISEAKLGALHSSVMACLFAVTAPLGVAIGXVICSFYNPNSPRALVIEGILDSISAGILVYMALXDLIXXDFMSKKMRCNPRLQMVSYFALFLGAGLMALIAVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RS45</accession>
    <name>A0A103RS45_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM dependent carboxyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007724">
        <property type="protein sequence ID" value="KVG72834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103RS45"/>
    <dbReference type="Gramene" id="KVG72834">
        <property type="protein sequence ID" value="KVG72834"/>
        <property type="gene ID" value="Ccrd_026229"/>
    </dbReference>
    <dbReference type="OMA" id="FHMATGE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG72834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="40030" checksum="CB72EA687A1ACDE8" modified="2016-04-13" version="1">MKSKEKMGLQVENILHMNTGNGESSYAQNSFLQEMVIRKTLPVFEHTIKGMADLDIDVFGQCFKIADLACSSGRNTLLFARTIMDIVDEVCKEYDRKGPQFEVCLNELYGNDFNTIFGMLPNFIAKLKKEKGENFGPSFVSAVPGSFYGRLFPDQSLHLVHSSYSVHWLSQLPEGLENNKANIYMSKTSPPNVIQGYQKQFYSDFTNFLNLRSEEIVCGGRMVLTFLGRSIADPTNINLFNLPFYTPCEDEVRNFIQNEGSFAIETLYGFQGNWDPYDTDYTNKNDLKEDSREHGKNASNAFRAVAEPLLTSHFGNSIIDVLFNKFERHVAEHLANKKTRYFNILISLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SVY1</accession>
    <name>A0A103SVY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zein-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007310">
        <property type="protein sequence ID" value="KVG97392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SVY1"/>
    <dbReference type="STRING" id="59895.A0A103SVY1"/>
    <dbReference type="Gramene" id="KVG97392">
        <property type="protein sequence ID" value="KVG97392"/>
        <property type="gene ID" value="Ccrd_026056"/>
    </dbReference>
    <dbReference type="OMA" id="YWDLICS"/>
    <dbReference type="OrthoDB" id="1047602at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080115">
        <property type="term" value="F:myosin XI tail binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007656">
        <property type="entry name" value="GTD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039306">
        <property type="entry name" value="MYOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31448:SF32">
        <property type="entry name" value="MYOSIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31448">
        <property type="entry name" value="MYOSIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04576">
        <property type="entry name" value="Zein-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51775">
        <property type="entry name" value="GTD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="GTD-binding" evidence="7">
        <location>
            <begin position="426"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG97392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="529" mass="59957" checksum="14A1878CFAD777DF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X6A7</accession>
    <name>A0A103X6A7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Wall-associated receptor kinase galacturonan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006365">
        <property type="protein sequence ID" value="KVH84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X6A7"/>
    <dbReference type="Gramene" id="KVH84859">
        <property type="protein sequence ID" value="KVH84859"/>
        <property type="gene ID" value="Ccrd_025443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="19345" checksum="057EBB5483799F70" modified="2016-04-13" version="1">MFSFATAGKYPTSKTYSLVNATNLAKPGCDSRWGDLIVPYPFGIGTNSNCSIGDGFDIHYNTSSDPPKASIRKTDYNSIKQISDSTLHISNMVATSLFDDSDIANSTRYVDPWTYAFFGDEDVFKFKPNQWAVLLAIQIVRVLTLQGRAVGIAASAKKAIREIPIYLRVAKVQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC72</accession>
    <name>A0A103XC72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)H dehydrogenase (quinone)</fullName>
            <ecNumber evidence="4">1.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_024577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + NADPH + H(+) = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsuE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005613">
        <property type="protein sequence ID" value="KVH88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC72"/>
    <dbReference type="STRING" id="59895.A0A103XC72"/>
    <dbReference type="Gramene" id="KVH88040">
        <property type="protein sequence ID" value="KVH88040"/>
        <property type="gene ID" value="Ccrd_024577"/>
    </dbReference>
    <dbReference type="OMA" id="MESAIVV"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000031">
        <property type="entry name" value="NADPH:quinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF22">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE (QUINONE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="13">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="197" mass="21672" checksum="37C4E45808739DE0" modified="2016-04-13" version="1">MESAIVVKPPIINVAAICGSLRKASFNHSLIRSAIDLSKQSVEGMSIQYVDLSPLPMLNTDLEIDGKYPPAVEAFRQKILQSDCFLFASPEYNYSVTAPLKNAIDWASRPPNVWADKAAAIVSAGGGFGGGRSQYVLRQCGIYVDLHFVNQPEFFLNVFEAPSRFDDEGNLIDPQAKERLKSVLLALKVLTLRLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCS4</accession>
    <name>A0A103XCS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005450">
        <property type="protein sequence ID" value="KVH88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCS4"/>
    <dbReference type="STRING" id="59895.A0A103XCS4"/>
    <dbReference type="Gramene" id="KVH88324">
        <property type="protein sequence ID" value="KVH88324"/>
        <property type="gene ID" value="Ccrd_024139"/>
    </dbReference>
    <dbReference type="OMA" id="DEEGHIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="862" mass="98068" checksum="943E3E61E14B4E2C" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD21</accession>
    <name>A0A103XD21_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chloride channel, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005391">
        <property type="protein sequence ID" value="KVH88502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD21"/>
    <dbReference type="STRING" id="59895.A0A103XD21"/>
    <dbReference type="Gramene" id="KVH88502">
        <property type="protein sequence ID" value="KVH88502"/>
        <property type="gene ID" value="Ccrd_026676"/>
    </dbReference>
    <dbReference type="OMA" id="CYYMIRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="29935" checksum="BC47005FAB49211D" modified="2016-04-13" version="1">MILCYLLMHSRVYVDDKSSFSDLLVLPLYSFRGGRRESVLLPSPGCFFDVESVLWPSPTESYLSLTNTTSTVILSVVIASVVSEIGLGSEPAFTVSDYDFCSPSELPLYLLLGIFCGLVSLSFSWCTSLMMVVTDKIQKTFVMPKAVFPVVGGFTVGPLALIYPEVLYWGFENVDTLLESRPLVKGLSVDLLLQLIAIKIAATSFCRACGLVGGYYAPSLFIGAAARMAYGRLTSFMISQLNSIFHLSGIEVAPPQAYGLVYIFCYYMIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDI6</accession>
    <name>A0A103XDI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005350">
        <property type="protein sequence ID" value="KVH88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDI6"/>
    <dbReference type="STRING" id="59895.A0A103XDI6"/>
    <dbReference type="Gramene" id="KVH88686">
        <property type="protein sequence ID" value="KVH88686"/>
        <property type="gene ID" value="Ccrd_026102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33700" checksum="28F85BA4378F6680" modified="2016-04-13" version="1">MNVVAKQQLKTDRPSSSWTFDPHPRLNPRQSTFDPHPQLDPRQSTQLHPVGSFFIINRVSTVSSDSHHTSRLLREFELQNELTCCILDFKKVELTNSGVMNDSGYSELFVLIELKTCIEADEIYKICSVIGSLTESSWAEGLELASTIGYLFPEVTNSGFQTILPELIFELAFLEPISLVISHYISKLAEVIPLLQSAMGGAGCASTTKFSGKFSRIPDQEVQRRNLYTQMSSSLVALDERSSEIKLDQNKKLHVVKASLIKKLHVAKVSRAPFTFGLFMNFAIEIVEARPPYLHKRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF06</accession>
    <name>A0A103XF06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005207">
        <property type="protein sequence ID" value="KVH89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF06"/>
    <dbReference type="STRING" id="59895.A0A103XF06"/>
    <dbReference type="Gramene" id="KVH89506">
        <property type="protein sequence ID" value="KVH89506"/>
        <property type="gene ID" value="Ccrd_008505"/>
    </dbReference>
    <dbReference type="OMA" id="FPPPENM"/>
    <dbReference type="OrthoDB" id="1931494at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF228">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="244" mass="26437" checksum="37B3B7CA994EB7D5" modified="2016-04-13" version="1">MAPRDRTPTAVKVNGGSAGVGVQVKEAHFRGVRKRPWGRYAAEIRDPGKKTRVWLGTFDTAEEAAKAYDAAAREFRGAKAKTNFPIHDDNGLLKVQKDELFKKASYVSQQSTSQGSTIESPSREAESVVPSLDLNLSYGVAAPPAVQFPFHQKNMYCFSPSTGAVTGFFTPPSNQMFYFPDGIFLSGKVQVHHSGGYDSSALPFRQSVSDDSNSSSVVDLKPLPTPASQRLIIDLNLPPPAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHF2</accession>
    <name>A0A103XHF2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHF2"/>
    <dbReference type="STRING" id="59895.A0A103XHF2"/>
    <dbReference type="Gramene" id="KVH90840">
        <property type="protein sequence ID" value="KVH90840"/>
        <property type="gene ID" value="Ccrd_007102"/>
    </dbReference>
    <dbReference type="OMA" id="NDSCYQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="437"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="488"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111310" checksum="961472820052CBFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHG0</accession>
    <name>A0A103XHG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHG0"/>
    <dbReference type="STRING" id="59895.A0A103XHG0"/>
    <dbReference type="Gramene" id="KVH90767">
        <property type="protein sequence ID" value="KVH90767"/>
        <property type="gene ID" value="Ccrd_007229"/>
    </dbReference>
    <dbReference type="OMA" id="IKMFKDV"/>
    <dbReference type="OrthoDB" id="686198at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045026">
        <property type="entry name" value="LIMYB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584:SF14">
        <property type="entry name" value="L10-INTERACTING MYB DOMAIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="302" mass="35006" checksum="C887F66A1CD9122B" modified="2016-04-13" version="1">MALNDGDRDELETVPDPATWTLSEENTFINIMAKEVKRGNRHSTTFSRSSWSFIEREFYEKTNRRYNHAQFRNKYNQLRIHYLWFTKLLKEPGFTWDPVLGTAIAADDVWESYLKTNKKARRFRKKGCPMYNELVIIFCDTATEYKDAYPLTRYPSHSGEKVDLEYESTNETPQAFPVGSSSAGKDCQSVGKRRRSPSPIPTLHLHKNKEAKIDESLKETIRMTVSNKQGSDPISDRTQNLEGCPEPSSFSITNCVKCLESIQDVDTTTYIKAIKMFKDVDWREMFMAMSAQRRSDWLASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHN1</accession>
    <name>A0A103XHN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHN1"/>
    <dbReference type="STRING" id="59895.A0A103XHN1"/>
    <dbReference type="Gramene" id="KVH90890">
        <property type="protein sequence ID" value="KVH90890"/>
        <property type="gene ID" value="Ccrd_007137"/>
    </dbReference>
    <dbReference type="OMA" id="WANAFDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000015">
        <property type="entry name" value="Metal tolerance protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000005">
        <property type="entry name" value="Metal tolerance protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF23">
        <property type="entry name" value="METAL TOLERANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="112"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="41435" checksum="744161F03364DAA1" modified="2016-04-13" version="1">MEEGKEALLSPTTPGGSRRGRRLSRRYSVNSLRNDFLTRLPDKVRSTVDIECSSPFALPSKSSESLTPGEKEYYEKQFATLKSFEEVDAIVSSEGIDEEDLDEQLQQERAMKISNYANILLLAIKIFATIETGSIAIAASTLDSLLDLMAGGILWFTHLSMQSINIYKYPIGKLRVQPVGIIIFAAIMATLGFQVLIQAVEQLIENKPPEKMSSLQLLWLYVIMISATVVKLALWLYCRSSGNEIVRAYAKDHYFDVVTNVVGLVAAVLGDMFYWWIDPLTYLVTRHPQVKRVDTVRAYTFGVLYFVEVDIELPEDLSLKEAHAIGETLQIKIEKLPEVERAFVHLDFECTHKPEHNVLTRLPNSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIG4</accession>
    <name>A0A103XIG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005045">
        <property type="protein sequence ID" value="KVH91338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIG4"/>
    <dbReference type="STRING" id="59895.A0A103XIG4"/>
    <dbReference type="Gramene" id="KVH91338">
        <property type="protein sequence ID" value="KVH91338"/>
        <property type="gene ID" value="Ccrd_006640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051596">
        <property type="entry name" value="Caulimoviridae_Movement"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028919">
        <property type="entry name" value="Viral_movement"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47599">
        <property type="entry name" value="CELL-TO-CELL MOVEMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47599:SF3">
        <property type="entry name" value="CELL-TO-CELL MOVEMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01107">
        <property type="entry name" value="MP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="51565" checksum="A6066DF9BA446747" modified="2016-04-13" version="1">MEQSESEHVIDITSSSGASSSSSSEDTVNQSNSRLNQDLPSTSMTAPVFQHSFSISNGGNTRNTSFGRRESGHGRRNPLNSGYWISTEIVITVSQIIAAIVVLCLSRHELPQAPLFTWVIGFIGIRAMSLNQGEKIEETQSIQLFSDEENVFVCENEASYSADLMIHQDLLKKISKLDLNLDKTKVFKIENSLMKAVQKAFKRKNEIFYCVSTKEISIDINDVSGQVYLPLITKEEIGQKLSKIPTDIRKKMNFVHIGALKILIKAQFRNGIDTPIKMALLDNRINNRRDSLLGVAQGNLAYDKFMFTVYPEFGVSLKTQNLNQILSFVHKFERTDLMNRGYKVFTITYLLEYALTNSHHSIDYRESSTIEIEDLFQEIGSIQENHFKKITNDNTNWVLDISKNKNQYGETSTIKTKEDQLLIDKPRSSTTREMVKSMSKRIDSMSILLKDVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ51</accession>
    <name>A0A103XJ51_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_006275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004910">
        <property type="protein sequence ID" value="KVH91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ51"/>
    <dbReference type="STRING" id="59895.A0A103XJ51"/>
    <dbReference type="Gramene" id="KVH91698">
        <property type="protein sequence ID" value="KVH91698"/>
        <property type="gene ID" value="Ccrd_006275"/>
    </dbReference>
    <dbReference type="OMA" id="HANVSKM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="11119" checksum="70828AA87F1FF6BE" modified="2016-04-13" version="1">MAYVGIVIDVVHPGRPNVSKAELKEKLARIYDVKDPNSIFVFKFRTHFGGGKSTGFGLIYDSVENAKKYEPKYRLVRHWEFVYLSVNKQHKQRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJN7</accession>
    <name>A0A103XJN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004879">
        <property type="protein sequence ID" value="KVH92015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJN7"/>
    <dbReference type="STRING" id="59895.A0A103XJN7"/>
    <dbReference type="Gramene" id="KVH92015">
        <property type="protein sequence ID" value="KVH92015"/>
        <property type="gene ID" value="Ccrd_005955"/>
    </dbReference>
    <dbReference type="OMA" id="CTISKFI"/>
    <dbReference type="OrthoDB" id="591587at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="510" mass="58708" checksum="D0DB6077E92FCD2C" modified="2016-04-13" version="1">MSSRSEEQRPINLPLLDQEESNDDVEIGNIQDPVQFLLHSAKNHRNKISPSIHMIPSRIRHLNPRVFNPRQVSIGPLHRKRKNLKAFEGTKAIFLHDLLHYSGVPPEQILETCVQKVNASLGRIKACYGNGMKSYSDDQITRMMVMDGCFILEFIYKLLKHKFDEEMVIEPISMAFDLVLLENQIPFLVLEHIFECTSSRFQPEVASLNALIILGLIPALGFLDLKCKKNKVFDGTDHILGFIHECYRPLPLCDKLPSDSFENRILGFIQDCYRPLCDAVKKAVEKIQTPDLGIDVNAQSSEDFEIDLSSNSDKFYSAVELDRSGVNFKPHHQPSPKNKKDGKWSMDIELTFPLCFWCRPWAKPTLRMPVMRIHNYTELVFRNLIAYEQLSPGSVCHYVTSYAIAMDRLIDNHEDVARLVKSQVLINTIGSNEEAAKLINDLRKEISSPHFFYVQVWKEMNGYHDRVVPRNIAKLRRTYFSNPWSSIALFAGIFLFLFTLVQTYYTINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJN8</accession>
    <name>A0A103XJN8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004880">
        <property type="protein sequence ID" value="KVH92013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJN8"/>
    <dbReference type="STRING" id="59895.A0A103XJN8"/>
    <dbReference type="Gramene" id="KVH92013">
        <property type="protein sequence ID" value="KVH92013"/>
        <property type="gene ID" value="Ccrd_005958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7288" checksum="EAC628CD7BC9CEAE" modified="2016-04-13" version="1">MMIEEDVELQNKNLNTALSLAAAAGTVHDIAKIMVEKKRALLTIPGSQAMMPLYVVAVFGKSDMVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKF0</accession>
    <name>A0A103XKF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase-like, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004824">
        <property type="protein sequence ID" value="KVH92323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKF0"/>
    <dbReference type="STRING" id="59895.A0A103XKF0"/>
    <dbReference type="Gramene" id="KVH92323">
        <property type="protein sequence ID" value="KVH92323"/>
        <property type="gene ID" value="Ccrd_005642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="191" mass="21566" checksum="F66277A5C88D87D1" modified="2016-04-13" version="1">MDAFSTRYPPFQRSLYISSPPGNHHRFPNLQHHGGVACRLAMRFHNLQRITTALNLSHRNRIQLSLKSTIYLDLSFDFNSNSIMDGSGAKNEIRSGDGLSAVKDTKETEKLPEIPPPPEKPLPGDCCGSGCVRCVWDIYYEELEEYNKLCKGKSDATIGSKLLHSIEENTKFIISKSNLLLFPRLPDMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKN6</accession>
    <name>A0A103XKN6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FRIGIDA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Frigida family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKN6"/>
    <dbReference type="STRING" id="59895.A0A103XKN6"/>
    <dbReference type="Gramene" id="KVH92464">
        <property type="protein sequence ID" value="KVH92464"/>
        <property type="gene ID" value="Ccrd_005488"/>
    </dbReference>
    <dbReference type="OMA" id="MMISNVP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012474">
        <property type="entry name" value="Frigida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791:SF41">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07899">
        <property type="entry name" value="Frigida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4 5" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="617" mass="67296" checksum="1726B9F45BF13BFB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMW2</accession>
    <name>A0A103XMW2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_004508</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="14">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004766">
        <property type="protein sequence ID" value="KVH93449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XMW2"/>
    <dbReference type="Gramene" id="KVH93449">
        <property type="protein sequence ID" value="KVH93449"/>
        <property type="gene ID" value="Ccrd_004508"/>
    </dbReference>
    <dbReference type="OMA" id="HIMQNIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000010">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF48">
        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="17">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH93449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="20826" checksum="9355BB6E661A7553" modified="2016-04-13" version="1">MLSRSRDLTGGRSWQVPLGRRDGLVSQASDTAXLPAFNDPISVQIRKFADKGGHTIGTSACALFSYRLYNFNNTNGPDPEINQAFLPQLRALCPNGGDGLRRVALDTGSVDRFGSSFYENLRNGRGVLESDAKLWSDRRTQGFVQGFLGTRGQPGSRFNSEFGRAMVKMGNTEVKTGMQGEIRRVCTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQA0</accession>
    <name>A0A103XQA0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004494">
        <property type="protein sequence ID" value="KVH94926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQA0"/>
    <dbReference type="STRING" id="59895.A0A103XQA0"/>
    <dbReference type="Gramene" id="KVH94926">
        <property type="protein sequence ID" value="KVH94926"/>
        <property type="gene ID" value="Ccrd_003003"/>
    </dbReference>
    <dbReference type="OMA" id="IFVVQTF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080162">
        <property type="term" value="P:endoplasmic reticulum to cytosol auxin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039305">
        <property type="entry name" value="PILS2/6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419">
        <property type="entry name" value="PROTEIN PIN-LIKES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419:SF1">
        <property type="entry name" value="PROTEIN PIN-LIKES 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="41535" checksum="81A9D333D29BC6A6" modified="2016-04-13" version="1">MHRLLSEILMDTQGGGESLFGSIKIAVLPIAKVFTMCFLGFLMASKYVNILPASGRKLLNGLVFSLLLPCLIFSQLGQAITWFIPFNVVLATISGSLVGLLVACIVRPPYPYFKFTIVHIGIGNIGNVPLVLIAALCRDKSNPFGDSAKCTQDGNAYISFGQWVGAIVLYTYVFQMLAPPPGGSFDIEDSKLPIKNTPKGSSPPEEVPLLTQEPETIDQDPPKDGKIKVFMKFLYEKLKLKQILQPPIIASILALVIGTIPFLKRDAMIPCILLALGGNLTDGPGSSKLGLKTTAAIIFGRLVLVPPAGLGIVTLADKLGLLPPDDKMFRFILLLQHSMPTSVLSGAVASLRGCGREAAAILFWVHIFAIISMAGWIVLYLNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQR4</accession>
    <name>A0A103XQR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQR4"/>
    <dbReference type="STRING" id="59895.A0A103XQR4"/>
    <dbReference type="Gramene" id="KVH95158">
        <property type="protein sequence ID" value="KVH95158"/>
        <property type="gene ID" value="Ccrd_002764"/>
    </dbReference>
    <dbReference type="OMA" id="MAIMPMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044827">
        <property type="entry name" value="GBF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012900">
        <property type="entry name" value="MFMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967:SF2">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967">
        <property type="entry name" value="G-BOX-BINDING FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07777">
        <property type="entry name" value="MFMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16596">
        <property type="entry name" value="MFMR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="397" mass="42397" checksum="2EEE1B6E0329285A" modified="2016-04-13" version="1">MGSRDMDKPAKEAKDSAKETPTSQEQSSGNAMGAVPDWTGFQAYSPMPPHGYLASSPQPHPYMWGVQHLMPPYGTAPHPYVAMYPHGGIYAHPSMPPGSYPFSPFAMPSPNGVAEVSGNTPGSMEVNGKSPEGKEKLPIKRSKGSLGSLNMITGKNSEPSKAGASANGSYPKSAESGSEGSSEGSDANSENVEFPNEIRIQARFYGRFGSGEASQNGNTVHGSQNGGPNTPHSVVNPTMGIVPISAGATLGSVAGPTTNLNIGMDYWSGANTSNIPAMRGHVTSAPVAGGMVAAGSRESMQPQLWIQDERELKRQRRKQSNRESARRSRLRKQAECDELAQRAETLKEENASLRAEVSRIRSDYEQLLAENASLKERVGESQEEARENHQTEVVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRH7</accession>
    <name>A0A103XRH7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRH7"/>
    <dbReference type="STRING" id="59895.A0A103XRH7"/>
    <dbReference type="Gramene" id="KVH95554">
        <property type="protein sequence ID" value="KVH95554"/>
        <property type="gene ID" value="Ccrd_002362"/>
    </dbReference>
    <dbReference type="OMA" id="TITNWNC"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119042" evidence="2">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="40068" checksum="741766A7E7663509" modified="2016-04-13" version="1">MERRRWLMLLLMACLFVGSTGRGFRIKHTVESAAYNHTLATILVEYASAVYMSDLTELFTWTCSRCDGLTKGFEVLELVVDVQSCLQAFVGVADDLDAIVIAFRGTQETSIQNWIEDLFWKQLDFDYPGCTDAKVHHGFFNAYNNTIMRSGILDGVNRAKEIYGDLKVMVTGHSMGGAMAAFCGLDLAHIYGSKNVQVMTFGQPRIGNAAFASYYSEHVPNTFRVTHEHDMVPHLPPYYRYFPEKTYHHFPREVWLYNVGFGFLIYEVEKICDGSGEDPECSRSVSGNSISDHLSYFGVEMGCDTSSKCRIVMAPTLASYGNVDNNGNFALSRLPSKFILKMKTEPGVNNTNHRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRQ5</accession>
    <name>A0A103XRQ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate kinase</fullName>
            <ecNumber evidence="5">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_002241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004379">
        <property type="protein sequence ID" value="KVH95668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRQ5"/>
    <dbReference type="STRING" id="59895.A0A103XRQ5"/>
    <dbReference type="Gramene" id="KVH95668">
        <property type="protein sequence ID" value="KVH95668"/>
        <property type="gene ID" value="Ccrd_002241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH95668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="46069" checksum="460990471FFEF79D" modified="2016-04-13" version="1">MATSSTSLEDVPSLDIMTELLRRFKCSSKPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKETMEKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVAQAEKLDEMLEKQRTKIDKVLDFAIDDSILEERITGRWIHASSGRTYHTNFALVTGEPLMQRKDDTAEVLKSRLQAFHRQTEPVIDYYKKKGVVAKLHAENPPKEVTVEISRKKSAIAGNDHDEIIVDAAMIKAPQMVTSATAFPTLDGFGKSPVEMASNNTFLVNAPSLDIMTEFKCSSKPHKRIIFIGPPGSGKGTQSLIIKEKYGLCHLATGDILRAVVAAKTPLGIKIKENMEKPLIQRKDDTAEVLKLRLEVFHRQTEPVIEYYKKKGVVAKIPAENPPNEVTAEVLKVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSV0</accession>
    <name>A0A103XSV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004343">
        <property type="protein sequence ID" value="KVH96257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSV0"/>
    <dbReference type="Gramene" id="KVH96257">
        <property type="protein sequence ID" value="KVH96257"/>
        <property type="gene ID" value="Ccrd_001665"/>
    </dbReference>
    <dbReference type="OMA" id="WYYNYLQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000163">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF454">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="52641" checksum="2587E4F813AB5B77" modified="2016-04-13" version="1">MSFTKIESDHIEFINLSSMESTPFNLLLFLTLLFHRHTHSSASTLPKEALPTKSGYLPVNSTTGSAIFYAFYEAQNPDDTSLSQTPLVIWLQGGPGCSSMTGNFYELGPWRLTPSLKQNVEHLELQPNPGSWNRIFGLLFLDNPIGTGFSIASTPEEIPTDQESVARHLFIAIRKFIALDPSFRYRPIYITGESYAGKYVPSIGYYILKRNPLLPLSKRVNLHGLAIGNGLTDPETQVGTHALQSYYHGLINEKQKTQLERLQFEAIQLTKAGNWSDATDARNNVFSFLQNATGLATLFDFRRYRPYDSIWVEEFLKNPEVKKALGVDESMVFEKCSKVVGAALHSDVMKSVRFKVEYLVKNTKLLLFQGQCDLRDGVFAAESWMKKMKWEGLQKFLDAERDIWYVNGGLAGYVQKSDNLSHVVVLAAGHFVSTDQAVNAQAMIEDWILDRSLFANKYIQNLFMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSW1</accession>
    <name>A0A103XSW1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPX2, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004343">
        <property type="protein sequence ID" value="KVH96254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSW1"/>
    <dbReference type="STRING" id="59895.A0A103XSW1"/>
    <dbReference type="Gramene" id="KVH96254">
        <property type="protein sequence ID" value="KVH96254"/>
        <property type="gene ID" value="Ccrd_001660"/>
    </dbReference>
    <dbReference type="OMA" id="CESDAME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044216">
        <property type="entry name" value="WDL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47067">
        <property type="entry name" value="TPX2 (TARGETING PROTEIN FOR XKLP2) PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47067:SF23">
        <property type="entry name" value="TPX2 (TARGETING PROTEIN FOR XKLP2) PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="7">
        <location>
            <begin position="404"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="578" mass="64884" checksum="34399B702AC139C1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU52</accession>
    <name>A0A103XU52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004079">
        <property type="protein sequence ID" value="KVH96919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU52"/>
    <dbReference type="STRING" id="59895.A0A103XU52"/>
    <dbReference type="Gramene" id="KVH96919">
        <property type="protein sequence ID" value="KVH96919"/>
        <property type="gene ID" value="Ccrd_000987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7829" checksum="BCA44E7D9A76DB0F" modified="2016-04-13" version="1">MHQEDVSSFQLQLKKAIWILFLFRVGVHRTEYNNVKRQKINVNAIIPVNFAADTRLILEDISLMKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVH8</accession>
    <name>A0A103XVH8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003823">
        <property type="protein sequence ID" value="KVH97652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVH8"/>
    <dbReference type="Gramene" id="KVH97652">
        <property type="protein sequence ID" value="KVH97652"/>
        <property type="gene ID" value="Ccrd_000230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051761">
        <property type="entry name" value="MLP-like_ligand-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31907">
        <property type="entry name" value="MLP-LIKE PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="15790" checksum="01D84B7AA3A3B2C1" modified="2016-04-13" version="1">MVLIGKLIMYVGINSHGDVFHEMYTTWLRFPQITFRVVRLMVNQELLGPSSSSTIPELSGKSVLEEVDEKNHKVVYNVIEGDLVEELYKSFKIIFHVEPKDDGQLAIWTLEFEKMNASIPYPTVEILFGISFNHFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVL1</accession>
    <name>A0A103XVL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVL1"/>
    <dbReference type="STRING" id="59895.A0A103XVL1"/>
    <dbReference type="Gramene" id="KVH97701">
        <property type="protein sequence ID" value="KVH97701"/>
        <property type="gene ID" value="Ccrd_000178"/>
    </dbReference>
    <dbReference type="OMA" id="HECAIND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF375">
        <property type="entry name" value="WRKY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="37867" checksum="3279114FE57B6097" modified="2016-04-13" version="1" fragment="single">LTHSFSPSLFVKPKTLDRAFSLSHAINSFDFSLFCTGSWYMDDKDKVDPVAGGFTSDNTWTFQGDYSFFGNDARESSVLNEFGWNFQPPPSVFDRIDSDVVGSSVSLPEVSVGVIASEVQAGSIDEAGDVSISNPLVSTSSSEDRMESSTASGDAAFGGKPPSSERAGKAKKKGPKRIRQPRFAFMTKSEIDHLEDGYRWRKYGQKAVKNSPFPRLSYYRCTNSKCTVKKRVERSSEDPTIVITTYEGQHCHHTVGFPRGLINHHEAVYARQLPPSSALQPANYSRAQFPSEMHAVVTSQSRPQLVSSESGDHMSHRLPQSSSQGSQVGQGLLGDIVPPRMRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVT2</accession>
    <name>A0A103XVT2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVT2"/>
    <dbReference type="Gramene" id="KVH97789">
        <property type="protein sequence ID" value="KVH97789"/>
        <property type="gene ID" value="Ccrd_000153"/>
    </dbReference>
    <dbReference type="OMA" id="GANDHHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33474:SF27">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10783" checksum="55C63FF72DB14898" modified="2016-04-13" version="1">MAANGFHLIVITLLAFSHLLFMANAISTSGKIHRHLLNESVEILASRNTKNQMMNMKETAFLEDEFMSERMDLEKTDYPGPGANKNHTPRPPQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWX1</accession>
    <name>A0A103XWX1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WEB family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WEB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWX1"/>
    <dbReference type="STRING" id="59895.A0A103XWX1"/>
    <dbReference type="Gramene" id="KVH98326">
        <property type="protein sequence ID" value="KVH98326"/>
        <property type="gene ID" value="Ccrd_023445"/>
    </dbReference>
    <dbReference type="OMA" id="WVHEANE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009904">
        <property type="term" value="P:chloroplast accumulation movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009903">
        <property type="term" value="P:chloroplast avoidance movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008545">
        <property type="entry name" value="Web"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054">
        <property type="entry name" value="HEAVY CHAIN, PUTATIVE, EXPRESSED-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054:SF89">
        <property type="entry name" value="WEB FAMILY, PREFOLDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05701">
        <property type="entry name" value="WEMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="188"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="91834" checksum="4431B6DF31EBF37A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY50</accession>
    <name>A0A103XY50_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY50"/>
    <dbReference type="STRING" id="59895.A0A103XY50"/>
    <dbReference type="Gramene" id="KVH99066">
        <property type="protein sequence ID" value="KVH99066"/>
        <property type="gene ID" value="Ccrd_022693"/>
    </dbReference>
    <dbReference type="OMA" id="RQFTISI"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF515">
        <property type="entry name" value="AMINO ACID TRANSPORTER AVT6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="464" mass="50138" checksum="353788EBB51A7403" modified="2016-04-13" version="1">MVGKDKAVRNDSIISHVNGRQEPATHSRSGRGSDDFDFQNIPPMSVSSEKGSGMSGAVFNLATTVIGAGIMALPATMKVLGLIAGVVFIFLMGVLSEISLELLVRFTHQCKATSYGEVVEHAMGKPARIVSEIFIILNNAGVLLVYLIIMGDVMSGSSRHSGVLEQWFGNGFWDDRRIVSLILLIIFLAPLCALSKIDSLSMTSAASVVLAILFVVIACVVTSIMLAEGKIGSPRLVPDFGSKSAILDLLVVIPIMSNAYVCHFNVQPIYNELEDRSPEKMNTVGRWTTVICVLIYWSTAIAGYLLFGKDTEPDVLTNFDKPLPVKGSEALSYIVRVGYIFHLILVFPVIHFSLRQTVDALAFKGKPPLSKSKTRCLGLTGAILIVVYLASVLIPSIWTAFKFTGATTAVSLGFVFPSLIALRLSRHGPEGLSSRERVLSWLMLILAIVVSVVGVVGNIYGMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYM5</accession>
    <name>A0A103XYM5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003612">
        <property type="protein sequence ID" value="KVH99323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYM5"/>
    <dbReference type="STRING" id="59895.A0A103XYM5"/>
    <dbReference type="Gramene" id="KVH99323">
        <property type="protein sequence ID" value="KVH99323"/>
        <property type="gene ID" value="Ccrd_022445"/>
    </dbReference>
    <dbReference type="OMA" id="NIFEERY"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="32452" checksum="4F8C8A56838283CD" modified="2016-04-13" version="1">MALPQLLPSPSSSYLTHHRLNPHTLSFSPSNFNSISLPHRRRHHRNHTSSLRCSSSSFSEKHENTPSPNSNDIVELPLFPLPLVLFPGAILPLQIFEYRYRIMMHTLLQTDLRFGVIYTDATSGTADVGCVGEVVKHERLVDDRFFIICKGQERFRVTKVVRTKPYLVAEVVWLEDRPSGNGEEDLEGLASEVESHMKDVIRLSNRLNGKPEKEAGDLRRNLFPTPFSFFVGSTFEGAPREQQALLELEDTMVRLKREKETLRNTLNYLSAASAVKDVFPSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYR6</accession>
    <name>A0A103XYR6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox KN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/BELL homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003612">
        <property type="protein sequence ID" value="KVH99329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYR6"/>
    <dbReference type="Gramene" id="KVH99329">
        <property type="protein sequence ID" value="KVH99329"/>
        <property type="gene ID" value="Ccrd_022443"/>
    </dbReference>
    <dbReference type="OMA" id="REACNPR"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006563">
        <property type="entry name" value="POX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07526">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00574">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH99329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="421" mass="47269" checksum="AEB0FA966CD41ED0" modified="2016-04-13" version="1">MVSPDSSSNPNSIHQFLISNPIPSQTHYESQPFDVYGVDLRSLGSYPHQSLNVLPTIQSLGERMSRSIDLIQAPPMADNEQDLNQHHQNQKLSLSLGSGLLFPSSTQYRGGRWNLISEEELREKTRKTFNPSDYCSSSSSSSLHQSSSTFYGTESISISIGSSRYLKPTQSLLEEIVSIGGKDLDSSNKSYAQKLSSSGWQGSLGLCSELKAELCSNGLSMEKQELQATLAKLISLLEEVERKYEQYYQQLEDVVSSFELNAGLGSGKSYTALALNAMSGHFSGLKDAILSQIYVTRKKILQDLPKINTGFSQLSLFDKETNRHNRIALQQLGMIASPRQTWRPIRGLPETSVMILRSWLFEHFLHPYPNDNEKLMLASQTGLSKNQVSNWFINARVRLWKPMIEEMYKEEFADSSEDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ27</accession>
    <name>A0A103XZ27_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BZR1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein BRASSINAZOLE-RESISTANT 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in brassinosteroid signaling. May function as transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the BZR/LAT61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003455">
        <property type="protein sequence ID" value="KVH99530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ27"/>
    <dbReference type="STRING" id="59895.A0A103XZ27"/>
    <dbReference type="Gramene" id="KVH99530">
        <property type="protein sequence ID" value="KVH99530"/>
        <property type="gene ID" value="Ccrd_022235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008540">
        <property type="entry name" value="BES1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033264">
        <property type="entry name" value="BZR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506">
        <property type="entry name" value="BES1/BZR1 HOMOLOG PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506:SF29">
        <property type="entry name" value="PROTEIN BZR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05687">
        <property type="entry name" value="BES1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1070">Brassinosteroid signaling pathway</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BES1/BZR1 plant transcription factor N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="21731" checksum="FA02CCE163E5AA66" modified="2016-04-13" version="1">MPVWVTDMINFDSDNQVLGTETPVFNGVAPGAELFDKIFNQGPLALCKEAGWVVLPDGTTFRKGCKPSPSSVEIKCTSANTTPSSSQRPSPPSSSFRSPSRLDSKNPPSNNPFGFLSNSIPPSLPPLRISSSAPVTPPLSSPTSKFPKKNNLDWKISPNNTLPPSVCQFLHHQCPLARTGTSGSGLLLYQSAMSLIGAPLVPSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZB3</accession>
    <name>A0A103XZB3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_022168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003437">
        <property type="protein sequence ID" value="KVH99600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZB3"/>
    <dbReference type="STRING" id="59895.A0A103XZB3"/>
    <dbReference type="Gramene" id="KVH99600">
        <property type="protein sequence ID" value="KVH99600"/>
        <property type="gene ID" value="Ccrd_022168"/>
    </dbReference>
    <dbReference type="OMA" id="CHVVEED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000002">
        <property type="entry name" value="Nac domain-containing protein 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF216">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="NAC" evidence="13">
        <location>
            <begin position="84"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH99600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="593" mass="66733" checksum="746ECB7D68769C71" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0E2</accession>
    <name>A0A103Y0E2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003396">
        <property type="protein sequence ID" value="KVI00220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0E2"/>
    <dbReference type="STRING" id="59895.A0A103Y0E2"/>
    <dbReference type="Gramene" id="KVI00220">
        <property type="protein sequence ID" value="KVI00220"/>
        <property type="gene ID" value="Ccrd_021545"/>
    </dbReference>
    <dbReference type="OMA" id="PNIRITQ"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF93">
        <property type="entry name" value="DNA POLYMERASE II SUBUNIT B3-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="226" mass="25660" checksum="CC9A4C07F5F5699F" modified="2016-04-13" version="1">MEEEQKAERGGSTPAPAKANGKRKVKKDFEEENTPDKVPIILSSSSNSHNHVNNGAKSESSEEEEQRQVEVSGEKDVVDDSVEAEDAANSTDASNKKKKAKKEVKEDKNQKKKKKKRKEEIEEKESSSLYQIPMNRVSRIIKSEDPNIRISQEAVFIINKASEKFLQLFTTEAYASAFLDRKKHIDYKHLSSVISKRRRFDFLSDFVPEKVKAEDALKESSPTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0Q2</accession>
    <name>A0A103Y0Q2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Embryo sac development arrest 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0Q2"/>
    <dbReference type="STRING" id="59895.A0A103Y0Q2"/>
    <dbReference type="Gramene" id="KVI00386">
        <property type="protein sequence ID" value="KVI00386"/>
        <property type="gene ID" value="Ccrd_021340"/>
    </dbReference>
    <dbReference type="OMA" id="IEMETRW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009561">
        <property type="term" value="P:megagametogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34657">
        <property type="entry name" value="EMBRYO SAC DEVELOPMENT ARREST 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34657:SF4">
        <property type="entry name" value="EMBRYO SAC DEVELOPMENT ARREST 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15647" checksum="D85C6DE3149EEC08" modified="2016-04-13" version="1">MNEQRSYGMMNPGASRLKRKDRESVFPAIRSPQPPPQKLGRATTVTASTTIPTSKGMSSHKLLAGYMAYEFLTKGTLLGQKFESTVQNQNQSGIEAETEKWRKGKESYKEITSLMMVKSDGGGIHIPGIVNPTQLGRWIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1D5</accession>
    <name>A0A103Y1D5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purple acid phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_021002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01003292">
        <property type="protein sequence ID" value="KVI00744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI00744">
        <property type="protein sequence ID" value="KVI00744"/>
        <property type="gene ID" value="Ccrd_021002"/>
    </dbReference>
    <dbReference type="OMA" id="YARVHTT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040974">
        <property type="entry name" value="Fn3_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778:SF3">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17808">
        <property type="entry name" value="fn3_PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010000032" description="Purple acid phosphatase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase Fn3-like" evidence="14">
        <location>
            <begin position="80"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="358"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="12">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI00744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="526" mass="58819" checksum="49E3A05DF45F4EF8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1Y5</accession>
    <name>A0A103Y1Y5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein beta WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003145">
        <property type="protein sequence ID" value="KVI01011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1Y5"/>
    <dbReference type="STRING" id="59895.A0A103Y1Y5"/>
    <dbReference type="Gramene" id="KVI01011">
        <property type="protein sequence ID" value="KVI01011"/>
        <property type="gene ID" value="Ccrd_020726"/>
    </dbReference>
    <dbReference type="OMA" id="ARIWTIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="31262" checksum="05F3127752005DA3" modified="2016-04-13" version="1" fragment="single">GGEVAKDHPSRDKNVAKGGLSFKEVETFFTSNDIVLCCHFSSDGKLLATAGNDKMVSVWNVESLCHLGNTPQQSNMITDVRFMPHSTVFATSSFDTTIRLWDAANISKFLVELHGHADRVISVDFNPHEREIVCSFQFRNLLAVASGNMILMIDIETDKKERLQGHARDIQSICWDQSGRYLASVSEDSARVWSTKSGWKCDYELYSTENMFKSCTFHPVHSLLLVIGGFQIFEFWDCVKGSKTRSIQLHSGIISSLTYSPEAGLIASTSNDGHIRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y314</accession>
    <name>A0A103Y314_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003011">
        <property type="protein sequence ID" value="KVI01581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y314"/>
    <dbReference type="STRING" id="59895.A0A103Y314"/>
    <dbReference type="Gramene" id="KVI01581">
        <property type="protein sequence ID" value="KVI01581"/>
        <property type="gene ID" value="Ccrd_020146"/>
    </dbReference>
    <dbReference type="OMA" id="ISMMDEG"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="541"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="617" mass="68588" checksum="2FE6802D864B9CD9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y355</accession>
    <name>A0A103Y355_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002860">
        <property type="protein sequence ID" value="KVI01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y355"/>
    <dbReference type="STRING" id="59895.A0A103Y355"/>
    <dbReference type="Gramene" id="KVI01654">
        <property type="protein sequence ID" value="KVI01654"/>
        <property type="gene ID" value="Ccrd_020068"/>
    </dbReference>
    <dbReference type="OMA" id="EITCANF"/>
    <dbReference type="OrthoDB" id="1904546at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05489">
        <property type="entry name" value="xylanase_inhibitor_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000041">
        <property type="entry name" value="Basic 7S globulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000045">
        <property type="entry name" value="Basic 7S globulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033868">
        <property type="entry name" value="Xylanase_inhibitor_I-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF103">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119345" evidence="5">
        <location>
            <begin position="25"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="46"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="438" mass="47203" checksum="0680EE4DE2A98C7E" modified="2016-04-13" version="1">MAEPSSYSLLFFCSFLLVVSSSVAKTSPRPKVLLLSVSKDAETLQYVTQVSQRTPLLPVKLTLDLGGDYMWVNCERGYTSSTYLPAPCGSAPCRLLNTTSCTTECYSAPAPDCYNNTCGHGPTNTVANTGTSGQLGADVFKIQSTDGKNVLPVVTVPRLYFICGSNFIEAGLASGVTGMAGLGRTGASLPAQLSSYFRFKRKFAVCLSSSTRSRGVVFFGNGPYTFLPNVDASSSVTYTPLIINPVTENGFLGDASPKYFIRVNSIKINDNRVLLNETLLSIDSEGYGGTTISTVDPYTILESSIYSAVVDAFVKAMPKNVKRVPSVAPFGACFSSKNIRRTRVGPAVPSIELVLQSESVYWRIYGANSMVEAREDVLCLGFVEAQTDFRPRFAVVIGGHQIEDNLLQFDLSRSRLGFSSSLLGRSTTCANFNFTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3B1</accession>
    <name>A0A103Y3B1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_019989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01002699">
        <property type="protein sequence ID" value="KVI01732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3B1"/>
    <dbReference type="Gramene" id="KVI01732">
        <property type="protein sequence ID" value="KVI01732"/>
        <property type="gene ID" value="Ccrd_019989"/>
    </dbReference>
    <dbReference type="OMA" id="KSAWLLY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI01732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="15190" checksum="D9E1615D036B07F8" modified="2016-04-13" version="1">MKSVGSAALKMVEEVWRQFNTIPGLMEGTTKPDYATCVKISTDASLKEMIPPGALVMITPLVAGTLFGVESLAGVLAGSLVSGVQIAISASNTGGAWDNAKKYIEAGGSEHARTLGPKGSEAHKAAVIGDTMGDPLKDTLGPSLKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y402</accession>
    <name>A0A103Y402_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="4">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_019596</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycolate + O2 = glyoxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:25311"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:25312"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Photosynthesis; photorespiration; glycine from 2-phosphoglycolate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002663">
        <property type="protein sequence ID" value="KVI02111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y402"/>
    <dbReference type="STRING" id="59895.A0A103Y402"/>
    <dbReference type="Gramene" id="KVI02111">
        <property type="protein sequence ID" value="KVI02111"/>
        <property type="gene ID" value="Ccrd_019596"/>
    </dbReference>
    <dbReference type="OMA" id="PEMQVWV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009854">
        <property type="term" value="P:oxidative photosynthetic carbon pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 13" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0323">Glycolate pathway</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI02111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="35672" checksum="DB569D78CF2611BA" modified="2016-04-13" version="1">MEVTNVSEYQAIAKEKLPKMAYDYYASGAEDEFRPRILIDVSKIDLTTTILGFKLSMPIMIAPTAFQKMAHPEGEYATARAASSAGTIMTLSSWATSSVEEVASTGPGIRFFQLYVYKDRNVVAQLVRRAEKAGFKAIALTVDTPRLGRREADIKNRFTLPPFLTLKNFEGLNLGKMDEANDSGLASYVAGQIDRTLSWKGVITAEDTRLAIQAGAAGIIVSNHGARQLDYVPATIMALEEVVKAAQGRVPVFLDGGVRRGTDIGRPVVFSLAAEGEAGVRKVLQMLREEFELTMALSGCTSLREITRDHIVTEWDAPRARPAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y747</accession>
    <name>A0A103Y747_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_017957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y747"/>
    <dbReference type="STRING" id="59895.A0A103Y747"/>
    <dbReference type="Gramene" id="KVI03744">
        <property type="protein sequence ID" value="KVI03744"/>
        <property type="gene ID" value="Ccrd_017957"/>
    </dbReference>
    <dbReference type="OMA" id="ITEYNIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="185"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="513"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI03744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="715" mass="78723" checksum="B59F679078A073AF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y913</accession>
    <name>A0A103Y913_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001928">
        <property type="protein sequence ID" value="KVI04734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y913"/>
    <dbReference type="Gramene" id="KVI04734">
        <property type="protein sequence ID" value="KVI04734"/>
        <property type="gene ID" value="Ccrd_016946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="28" mass="3402" checksum="6604B3294D0CF81B" modified="2016-04-13" version="1">MYCQIFNMIPQDLVPFKHHASRLKRVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB37</accession>
    <name>A0A103YB37_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARID/BRIGHT DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB37"/>
    <dbReference type="STRING" id="59895.A0A103YB37"/>
    <dbReference type="Gramene" id="KVI05831">
        <property type="protein sequence ID" value="KVI05831"/>
        <property type="gene ID" value="Ccrd_015822"/>
    </dbReference>
    <dbReference type="OMA" id="SCGEWAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15615">
        <property type="entry name" value="PHD_ARID4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042293">
        <property type="entry name" value="ARID4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46694">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46694:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="625"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="814" mass="89846" checksum="81B676D9B8647B21" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBW3</accession>
    <name>A0A103YBW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBW3"/>
    <dbReference type="STRING" id="59895.A0A103YBW3"/>
    <dbReference type="Gramene" id="KVI06250">
        <property type="protein sequence ID" value="KVI06250"/>
        <property type="gene ID" value="Ccrd_015387"/>
    </dbReference>
    <dbReference type="OMA" id="DCQFVRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36335">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36335:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="52642" checksum="AB6348D963FAF370" modified="2016-04-13" version="1">MKALRRCRNNLEVDNVVLIDVDSYNFNNVIVIDVPESHSKKVGGSNGLTNDRSRPLRTYIYIDDDESPSNHHAGTHADSERNFEDDASSSRRYGPDTHFAQENISPVKLSKGKRTYSGISSNNRNSFSLQSDSDSSDDDDSPDCEFMEDFSGKLREQWERASLKRKAGVHNDHIGRRDNSSSFKSSRGAHNDSGVNKNKQKYAQASTSKGKSRQPAYMQGYQHEDRIRHAESSLSDCDARNEVDVDHGKADSRVGNETEDCSQCSPVHRDDKHEHMPSTSSDEENEKNDLDVAPTIGAVPVQSSIIDQREKLKETDEYKRALEEEWSARQIALKIQAEEAQQLRRLQKRKKAETLRLLDMERRQKQRVEEIRESQKKDEENMNLKEVYRTEVRHELNKLEKTCLDMASLLRGLGIQVRAAYKRALLSFHPDRAAGSDMRQQVEAEEKFKLISRMKEKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBY3</accession>
    <name>A0A103YBY3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">High-affinity nitrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nitrate transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001842">
        <property type="protein sequence ID" value="KVI06274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBY3"/>
    <dbReference type="Gramene" id="KVI06274">
        <property type="protein sequence ID" value="KVI06274"/>
        <property type="gene ID" value="Ccrd_015382"/>
    </dbReference>
    <dbReference type="OMA" id="ACQFEIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010167">
        <property type="term" value="P:response to nitrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016605">
        <property type="entry name" value="Transptr_NO3_Nar2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806:SF1">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16974">
        <property type="entry name" value="NAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012939">
        <property type="entry name" value="Transpt_NO3_Nar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017107556" description="High-affinity nitrate transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="200" mass="22200" checksum="88577226E4E1EE5C" modified="2016-04-13" version="1">MEVPAGFLLVSLLLFSFAATGYGITFSSLPRSLVVTTSPTQGQGEEQITVTWALNQTFPAGTDSAYRTVKVKLCYAPISQKDRSWRKTEDEMKKDKTCQHKIVSRPYSASNNSFSWTIMRDIPSATYFVRAYVFNAEDHEVAFGQNTNAERATNLFEVQAITGRHASLDIASVCFSAFSIVALAGFFYMEKSKGKASQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC52</accession>
    <name>A0A103YC52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001832">
        <property type="protein sequence ID" value="KVI06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC52"/>
    <dbReference type="STRING" id="59895.A0A103YC52"/>
    <dbReference type="Gramene" id="KVI06370">
        <property type="protein sequence ID" value="KVI06370"/>
        <property type="gene ID" value="Ccrd_015274"/>
    </dbReference>
    <dbReference type="OMA" id="YIRINHD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="7">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="181" mass="20728" checksum="D2C0173027EA803D" modified="2016-04-13" version="1">MRGEGCVFNVELTDENASGTQMQATMFNEAARKFFDRLEIGKVYCISKGTIKVANKQFGTVDNDYEMTLSKYSRVMEAINESILVPERRFNFVPIDQLGLYFNQKDLVDKSSRKKSVVVCLWNDHATYLGQELLDMVDKSPVVAIKSLKVRDFRGVSLPTLPNSYIRINHDISQCLKLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCB6</accession>
    <name>A0A103YCB6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_015191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + H2O = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21209"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001825">
        <property type="protein sequence ID" value="KVI06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCB6"/>
    <dbReference type="STRING" id="59895.A0A103YCB6"/>
    <dbReference type="Gramene" id="KVI06459">
        <property type="protein sequence ID" value="KVI06459"/>
        <property type="gene ID" value="Ccrd_015191"/>
    </dbReference>
    <dbReference type="OMA" id="ANYFIGF"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000003">
        <property type="entry name" value="Phosphoserine phosphatase SerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000114">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="37225" checksum="9AD5994E6EAC0637" modified="2016-04-13" version="1">MQQGGTPDDRRRGGKDARGRREAVMGLPPHPLFSVSPIYSLLVSNEQINLMEGLISSRIIPIRAYGNQGNTPLFPTQTSSRRRVFYGPIRMMGPSTSSNSKAGSVKPLTASSSGRLDNTLPSKEVLDIWQKADAVCFDVDSTVCVDEGIDELAEFCGAGKAVAEWTARAMGGSVPFEEALAARLSLFKPSLSQVQDFLEKRPPRLSPGIKELVQKLKESGKTVYLISGGFRQMINPVASILGVPTENIFANQLLFKTSGEFSGFDANEPTSRSGGKPFAVELLRKAHGYKMVVMIGDGATDLEAQKPGCADLFICYGGVQLREAVSAKAGWLVFNFKDLINSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCJ3</accession>
    <name>A0A103YCJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_015038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001785">
        <property type="protein sequence ID" value="KVI06611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YCJ3"/>
    <dbReference type="Gramene" id="KVI06611">
        <property type="protein sequence ID" value="KVI06611"/>
        <property type="gene ID" value="Ccrd_015038"/>
    </dbReference>
    <dbReference type="OMA" id="KSYGEHD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20654">
        <property type="entry name" value="CYP82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000026">
        <property type="entry name" value="Cytochrome P450 82C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF26">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI06611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="494" mass="55598" checksum="A1802666FC6C6808" modified="2016-04-13" version="1" fragment="single">KKSEPPKAKGAWPIIGHLHLLGGSQSPQKVLGDMADIYGPIFSINLGVHQALVVSNKEIAKECYTTNDKVFASRPKXVASELMGYNYAMFGLAPYGEHWRQVRKIIMLEVLSQRRVEMLGHVRVSELXASSRXIYEAWVNHKENGGSDMVKVDMQQWFGNLVLNVVVRIISGKRFSPNDKEGVRFQKVARKFFELLGAFVVSDFIPYIKRLDLGGYEKEMKTIAKEMDNVIDGWLEEHKREKGSEQQLEGNQVFMDVLISILEGASEEDFPGFDHNXIIKASCLAILTAGLDTTSGTLTWALSLLXNNPKALKVAQDEIDEHVGRERLVQESDMKNLVYLEAIIKETLRLYPAAPLAVPHESMEDCSVSGYDIPKGTRLLVNLWKMHRDPDIWSDPNEFQPERFLTSQKDIDVKGKHFELLPFGSGRRMCPGVFFALQAMRLTLATLLQQFMLRNPSNEPVDISESWGLTTSKATPLEVLLSPRLSHGMYPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEA3</accession>
    <name>A0A103YEA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, CHCC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEA3"/>
    <dbReference type="STRING" id="59895.A0A103YEA3"/>
    <dbReference type="Gramene" id="KVI07512">
        <property type="protein sequence ID" value="KVI07512"/>
        <property type="gene ID" value="Ccrd_014080"/>
    </dbReference>
    <dbReference type="OMA" id="TTHTAKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="16671" checksum="E947751B991B8EE5" modified="2016-04-13" version="1" fragment="single">CVVFSLSIRSDATKNTKRKCRRSSTLKYPRSSFPYFNHSSSQLISMATIGAKRGYAMASNFLKALKTSSSSTSVRRFSGVVNSEITTTHTAKWMQLINEVPPIKVEGRIVACEGDTNPALGHPIEFICLDLSEPAVCKYCGLRYVQDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFE9</accession>
    <name>A0A103YFE9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001318">
        <property type="protein sequence ID" value="KVI08092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFE9"/>
    <dbReference type="Gramene" id="KVI08092">
        <property type="protein sequence ID" value="KVI08092"/>
        <property type="gene ID" value="Ccrd_013540"/>
    </dbReference>
    <dbReference type="OMA" id="AKFTMAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040273">
        <property type="entry name" value="PIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245:SF4">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119673" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7927" checksum="39AAB52AF78450F5" modified="2016-04-13" version="1">MAIINKTYTLLVVVIILIAVMSPVVVEGRVLTEDFVRANHLATYSTVYETAKNGMCIWLQQLASGPSPKGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG41</accession>
    <name>A0A103YG41_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001115">
        <property type="protein sequence ID" value="KVI08471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG41"/>
    <dbReference type="STRING" id="59895.A0A103YG41"/>
    <dbReference type="Gramene" id="KVI08471">
        <property type="protein sequence ID" value="KVI08471"/>
        <property type="gene ID" value="Ccrd_013157"/>
    </dbReference>
    <dbReference type="OMA" id="IQFPLEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119690" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI08471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="258" mass="28818" checksum="626DB58589406350" modified="2016-04-13" version="1">MKPTVALLLLSFTLLFSLFSAFQSDELLVDDEQFGLGKRPSPELDLSISSSSPSIPSRSHSPPKPIRKRSADSNSDSRVQFALEHAFGDSDDFSTAGTFTARLKTYGGHGTLTKLRFTRNDLSTIEQEKFKKLLENDDFYTIRVPSDVLNPPGRDYVISSVKARCLPNDGLDENFIIHMPAKWSFNSHAVLKYSEQAPRRPMFSEDIGSGEMGEDEGWMYFIPLVIIVVNAFTQAMNMPEEQASAQTQQPVGAAMQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG66</accession>
    <name>A0A103YG66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin/actin-like conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001110">
        <property type="protein sequence ID" value="KVI08516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG66"/>
    <dbReference type="STRING" id="59895.A0A103YG66"/>
    <dbReference type="Gramene" id="KVI08516">
        <property type="protein sequence ID" value="KVI08516"/>
        <property type="gene ID" value="Ccrd_013113"/>
    </dbReference>
    <dbReference type="OMA" id="PNIMVGM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048767">
        <property type="term" value="P:root hair elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI08516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="45669" checksum="18EA4D357D50C51A" modified="2016-04-13" version="1">MKGCQRQVLAIDDLNLLKSSYLMIDRSCFELLVKMADTEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDSLMKILTERGYMFTTTAEREIVRDMKEKLAYVALDYEQELETAKSSSSVEKNYELPDGQVITIGAERFRCPEVLFQPSLIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKGEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG87</accession>
    <name>A0A103YG87_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha crystallin/Hsp20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001111">
        <property type="protein sequence ID" value="KVI08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG87"/>
    <dbReference type="STRING" id="59895.A0A103YG87"/>
    <dbReference type="Gramene" id="KVI08513">
        <property type="protein sequence ID" value="KVI08513"/>
        <property type="gene ID" value="Ccrd_013132"/>
    </dbReference>
    <dbReference type="OMA" id="YSYMAPL"/>
    <dbReference type="OrthoDB" id="1927234at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000049">
        <property type="entry name" value="Increased DNA methylation 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039321">
        <property type="entry name" value="IDM2/3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34661:SF3">
        <property type="entry name" value="INCREASED DNA METHYLATION 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34661">
        <property type="entry name" value="INCREASED DNA METHYLATION 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="316"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48233" checksum="6B10CA3333EFFAC6" modified="2016-04-13" version="1">MEGSFPVREYLIDMGSDMDDKSSGRTPTDDQFFLLYFIMGTYFGPDLKEETQKSVFQRRAEGLPPYTPEKLAGSCIKTVEVERVYYYVLRKADPSIVLKLPWLQQFFHGNLSTSTRSPTLPFPQFDDLFPPNLHPHSMFKGQYEAINNIVFISDPNTLYIGPEYLERFKRLTRLEDVRLDRDDARRHTTVDGKVLYNIDVQEIDCHKESRPTSSGGPEEETPPLSPLLKHKGSLPTNGVPYSDTPPIRSVVGNSTPISGCVTNNGGSADCLSTGMKSSALAELGSDMIFLPSRPTREEWINIVNATKSGCALTGSATMGHIGPNIGSIDIGECEDSYLFRVSLPGVKRDEREFSCEVEDDGKVSVRGATVTGEKTVCRFDQIFEMQSQKLCPPGHFSVSFKLPGPVDPQQFSGNFGTDGILEGIVMKARRKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGF1</accession>
    <name>A0A103YGF1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001099">
        <property type="protein sequence ID" value="KVI08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGF1"/>
    <dbReference type="STRING" id="59895.A0A103YGF1"/>
    <dbReference type="Gramene" id="KVI08651">
        <property type="protein sequence ID" value="KVI08651"/>
        <property type="gene ID" value="Ccrd_012974"/>
    </dbReference>
    <dbReference type="OMA" id="FRNIMIV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="661" mass="71403" checksum="C2FBD1C5B3703DB9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH15</accession>
    <name>A0A103YH15_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001077">
        <property type="protein sequence ID" value="KVI08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH15"/>
    <dbReference type="STRING" id="59895.A0A103YH15"/>
    <dbReference type="Gramene" id="KVI08960">
        <property type="protein sequence ID" value="KVI08960"/>
        <property type="gene ID" value="Ccrd_012680"/>
    </dbReference>
    <dbReference type="OMA" id="TETKFNS"/>
    <dbReference type="OrthoDB" id="1922547at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304:SF1">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="228" mass="24985" checksum="2A69FF7CE6852F58" modified="2016-04-13" version="1">MSCNGCRVLRKGCSDNCILRPCLQWIDTPEAQGHATVFVAKFFGRAGLMSFISAVPENQRPSLFQSLLFEAAGRTVNPVNGAVGLLWTGNWHVCQASVDTVLRGGTLRPIPELNDGFPTMPKLGDSFQTDATFPDILKLQDPVTHPRSKVQRRRRACEPPSNMTQSQDLDLNLNQSFPAVKGSPEKRRQGSPSMNSEDSVTTTCLDGGFGEYSYIQGGGEVHLLNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH93</accession>
    <name>A0A103YH93_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanal + NADP(+) + H2O = octanoate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:59904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:59905"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YH93"/>
    <dbReference type="Gramene" id="KVI09081">
        <property type="protein sequence ID" value="KVI09081"/>
        <property type="gene ID" value="Ccrd_012462"/>
    </dbReference>
    <dbReference type="OMA" id="MQDPFVI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000065">
        <property type="entry name" value="Aldehyde dehydrogenase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="509" mass="55277" checksum="D0845E536B865809" modified="2016-04-13" version="1">MATRRLSSVLSSSYAPALLRSLGRYSSRGTGIARLSTAAALEEPITPHVQVEHTKLLINGQFVDSASGKTFPTLDPRTGHVIANVAEGDIEDVNRAVSAARKAFDEGPWPKMTAYERSRIMLRFADLLEKHADEITALEVWDNGKPYDQAAADEIPLLIRLFRYYAGWADKIHGLTIQADGXHHXXXXXXPIXVAGQIIPWNFPLLMYAWKVGPALACGNTVVLKTAEQTPLSALYVSKLFLEAGLPPGVLNIVSGYGPSAGAALASHMDVDKLAFTGSTETGKIVLGLAAQSNLKPVTLELGGKSXFIVCEDANVDEAVDLAHLALFYNQGQCCCAGSRTYVHERVYDEFVEKAKARALHRVVGDPFKKGVEQGPQVDSEQFEKILKFIRSGVDSGATLEIGAKEEIFGPVQSILKFKDVNEVIRRSNASPYGLAAGVFTQNLDTANTLTRALKAGTVWINTFDVFDAAIPFGGYKMSGHGREKGIYSLSNYLQIKAVVTRLKNPAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHF4</accession>
    <name>A0A103YHF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. The H form is known to activate a number of cytosolic enzymes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the thioredoxin family. Plant H-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHF4"/>
    <dbReference type="STRING" id="59895.A0A103YHF4"/>
    <dbReference type="Gramene" id="KVI09146">
        <property type="protein sequence ID" value="KVI09146"/>
        <property type="gene ID" value="Ccrd_012483"/>
    </dbReference>
    <dbReference type="OMA" id="HAMADKF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000104">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF413">
        <property type="entry name" value="THIOREDOXIN H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15540" checksum="481C9B235600E1EA" modified="2016-04-13" version="1">MGSVASALLGGGDNTPEGDSSSEESRVIEFHSSNRWQLHYNQSKQSPKLMVVDFSATWCGPCKMLEPFIRSLASKYQEIDFIKIDVDELKDVAQEFGVQAMPTIVVLKQGKEVERVVGAKKDELEQKILKHREVPKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI67</accession>
    <name>A0A103YI67_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_012061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001056">
        <property type="protein sequence ID" value="KVI09552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI67"/>
    <dbReference type="STRING" id="59895.A0A103YI67"/>
    <dbReference type="Gramene" id="KVI09552">
        <property type="protein sequence ID" value="KVI09552"/>
        <property type="gene ID" value="Ccrd_012061"/>
    </dbReference>
    <dbReference type="OMA" id="HDRINTA"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000044">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000073">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF22">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="16">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="16">
        <location>
            <begin position="237"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI09552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="477" mass="54240" checksum="438C85D1621319B3" modified="2016-04-13" version="1">MNNMKQLHKQSTANQRRDEEMPTSQTPPYSPKFPKHQSSSRYLPRSINYILKEQRLLFILVGILIGSAFFILKPSISSFTITDASDENQTTSLTRSIAFSHPDTTSHYYRPINQATGRVPVAIGRKKRRVVVTGGSGFVGSHLVDKLIARGDDVIVIDNFFTGRKENVAHHFGNPRFELIRHDVVEPILLEVDQIYHLACPASPVHYKFNPVKTIISFFRVGYLKVMSLEFLNWCNYKTNVMGTLNMLGLAKRIGARFLLTSTSEVYGDPLEHPQKETYWGHVNPIGVRSCYDEGKRTAETLTMDYHRGDGVEPDMWQLWFTLQVRIARIFNTYGPRMCLDDGRVVSNFVAQAIRKQPMTVYGDGKQTRSFQYVSDLVDGLMALMEGEHIGPFNLGNPGEFTMLELAQVVKETIDPSATIEFKENTADDPQKRKPDISKAKSMLNWEPKITLREGLPRMASDFRNRILNEDEGKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ28</accession>
    <name>A0A103YJ28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ28"/>
    <dbReference type="STRING" id="59895.A0A103YJ28"/>
    <dbReference type="Gramene" id="KVI10019">
        <property type="protein sequence ID" value="KVI10019"/>
        <property type="gene ID" value="Ccrd_011607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33879">
        <property type="entry name" value="17.6 KDA CLASS II HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33879:SF3">
        <property type="entry name" value="17.6 KDA CLASS II HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="83" mass="9484" checksum="0424676FD86BCDD8" modified="2016-04-13" version="1">MKVHPAPNKRNITVRYDFGSQSNAAATICRQKKLRQLPHVFAKVLELPFYADADVSIEETSDSLIFIVDTDDDRVWGEGFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJC0</accession>
    <name>A0A103YJC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJC0"/>
    <dbReference type="STRING" id="59895.A0A103YJC0"/>
    <dbReference type="Gramene" id="KVI10176">
        <property type="protein sequence ID" value="KVI10176"/>
        <property type="gene ID" value="Ccrd_011403"/>
    </dbReference>
    <dbReference type="OMA" id="QDWKSDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000003">
        <property type="entry name" value="Cyclic nucleotide-gated ion channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000024">
        <property type="entry name" value="Cyclic nucleotide-gated ion channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651:SF5">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="413"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="645" mass="73921" checksum="B9520CC267A5D090" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJE3</accession>
    <name>A0A103YJE3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">X8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJE3"/>
    <dbReference type="STRING" id="59895.A0A103YJE3"/>
    <dbReference type="Gramene" id="KVI10241">
        <property type="protein sequence ID" value="KVI10241"/>
        <property type="gene ID" value="Ccrd_011375"/>
    </dbReference>
    <dbReference type="OMA" id="ENASPFC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000001">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044788">
        <property type="entry name" value="X8_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044">
        <property type="entry name" value="BETA-1,3 GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044:SF28">
        <property type="entry name" value="CARBOHYDRATE-BINDING X8 DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="199"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="286" mass="29947" checksum="6447F8E84BD400C8" modified="2016-04-13" version="1">MSIHYARLPGALTLSSRYHVVNRLADDFPLPPVDPLSPVLPEAYCSYPPGSSPPSTTSLPTPTSPGFSPPSTTSLPPPASPAFSPPTTTSPPVSVSPTIGSYTPSPSPPASSSSSSYPTPPFSYSTPSTPPTTTTPGSPATYQPSPVMSPPYNFEPSPPTFSFPSPTGFIPAPPLFEPPVVYPPPTGPPPAHSEPESALWCVAKPSVPDPIIQEAMNYACGSGADCESLQPNGDCYQPDTLFAHASYAFNSYWQRTKVAGGTCEFGGSAMLVTVDPSYDGCHFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJU8</accession>
    <name>A0A103YJU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001023">
        <property type="protein sequence ID" value="KVI10342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJU8"/>
    <dbReference type="Gramene" id="KVI10342">
        <property type="protein sequence ID" value="KVI10342"/>
        <property type="gene ID" value="Ccrd_011277"/>
    </dbReference>
    <dbReference type="OMA" id="MCRTYVP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46151">
        <property type="entry name" value="NEP1-INTERACTING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46151:SF12">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25079" checksum="0FECA12E61B8DF3A" modified="2016-04-13" version="1">MLPLLSSLFNAILIPTPTPTPTATVLLHFSADKMADSKIRNVINRIFTALLTCAFALGGAGIGIITGAIKGQTTETGLVRGAGVGAVTGAITALQLMEMMANGESFSKVALLHSLLNGKVFMEWVSPAVLKAYQWQASAMEMSFSDMFDMDSNGIRGLSEDIIDSLPKRIFGNSTQNDNECNETSCTICLQDFKNGEEGRELLNCRHVFHLKCIDEWLIRQGSCPICRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJZ3</accession>
    <name>A0A103YJZ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_011064</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001016">
        <property type="protein sequence ID" value="KVI10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YJZ3"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000004">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000433">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF61">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119795" description="non-specific serine/threonine protein kinase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="15">
        <location>
            <begin position="437"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="16">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="16">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="627" mass="69538" checksum="A5DE5E75BF1D8D6B" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK54</accession>
    <name>A0A103YK54_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="3 9">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="3 9"/>
    <dbReference type="EMBL" id="LEKV01001017">
        <property type="protein sequence ID" value="KVI10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK54"/>
    <dbReference type="STRING" id="59895.A0A103YK54"/>
    <dbReference type="Gramene" id="KVI10525">
        <property type="protein sequence ID" value="KVI10525"/>
        <property type="gene ID" value="Ccrd_011068"/>
    </dbReference>
    <dbReference type="OMA" id="EPVSSHF"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000024">
        <property type="entry name" value="Folate gamma-glutamyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119800" description="folate gamma-glutamyl hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="341" mass="38107" checksum="08F5D6BFDC507745" modified="2016-04-13" version="1">MWNYIWILFLIYLLIEISFAKAASVDDGLTSTCPALDPRLNYRPIIGILSHPGDGASGQLSNATDASYIAASYVKFVESAGARVIPLIYNEPPEVLQSKLNLVNGVLFTGGWSKAGLYFDVVEGIFNQVLKKNDAGDHFPLLAICLGFELLTMVISKNNNILEAFSASNQASTLQFMKNVNIEGTLFQRFAPELIAKLSTECLVMQNHKFGISPETFQGNMELCSFFKILTTSRDENNKVYVSTVQSESYPVTAVQWHPEKNAFEWGLSMIPHSDDAIQVTQHVANFFVSEARKSFNNPPAKEVLDNVIYNYSPTYRGKEGKGYDEVYIFTEKAAPFHYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLX2</accession>
    <name>A0A103YLX2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_010001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000075">
        <property type="protein sequence ID" value="KVI11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLX2"/>
    <dbReference type="Gramene" id="KVI11585">
        <property type="protein sequence ID" value="KVI11585"/>
        <property type="gene ID" value="Ccrd_010001"/>
    </dbReference>
    <dbReference type="OMA" id="EACFRLP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17315">
        <property type="entry name" value="MFS_GLUT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="52"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="492" mass="52884" checksum="345CF050680E3718" modified="2016-04-13" version="1">MLAHSHGSSLMYKRMPSRDGANPVDLEDESGLLQDDMVQELTHPPLINSLPHVVVATIVSFLFGYHLGVVNEPLESISYDLGFNGNSLAEGFVVSTCLGGAFIGSLLSGWIADGVGRRRAFQLCAMPMVVGAACSATTSNLGGMLLGRFLVGIGLGIGPSVASLYITEVSPPSVRGTYGSFIQISTCLGLLGSLLIGIPVKSIPGWWRMCFWLSTIPAIVLAIAMMFCAESPHWLCKSGRNAEAEVEFRKLLGAAHVRSAMAELLKSNRGDENDTVTISELLCGRHSRVVFIGSTLFALQQLSGINAVFYFSSTVFRSVGVSPNLANAFVGIVNLLGSIIALLLMDKLGRRVLLLWSFFGMAISTVFQVVAAGLFASTSGALYLSVGGMLMFVFSFAVGAGPVPGLLLSEIFPSRIRAKAMAFCMSVHWVFNFIVGLLFLRLLEVMGPQLLYTMFGAICLNGVMFVKKHIMETKGKSLQEIEIALLPQEYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMG3</accession>
    <name>A0A103YMG3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_009802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01000043">
        <property type="protein sequence ID" value="KVI11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMG3"/>
    <dbReference type="STRING" id="59895.A0A103YMG3"/>
    <dbReference type="Gramene" id="KVI11784">
        <property type="protein sequence ID" value="KVI11784"/>
        <property type="gene ID" value="Ccrd_009802"/>
    </dbReference>
    <dbReference type="OMA" id="FFWFAKE"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047213">
        <property type="term" value="F:anthocyanidin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033485">
        <property type="term" value="P:cyanidin 3-O-glucoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031542">
        <property type="term" value="P:positive regulation of anthocyanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000129">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1494">
        <property type="entry name" value="FLAVONOL 3-O-GLUCOSYLTRANSFERASE UGT76E12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="471" mass="51780" checksum="4ADF560E3B1A6A83" modified="2016-04-13" version="1">MEDITTGNHNNGGSRPERHVAVFAFPFSSHPPLLLTLVRRLASASPTVVFSFFNTPDSNRSLFSDFSCHNIKPFDISDGIPEGYVFLGKPQEAINLFLAVAEEELRKAVKVATADIGLKVSCLVVDAFFWFSGDMAEEMNIPWVAFWTAGACSLSAHFYTDLIRSKSSELLKGSSAVPNEDEIVDFVPGFPGIRLSDLPSGVLFGNLESPFSTTLHKMGRNISRATAVPINSFQQLDPDLTRNLTSELNNFLNIGPFNLITSKQNPPSKVDEFSCISWLESQKPRSVAYISFGTVCRPLPHELVAIAEALEETKTPFLWSINNDSKKHFLEGFLERTAANGSGKVVPWAPQVQVLEHIAIGVFVTHGGWNSVLESIGAGVPMICRPFFGDQQINTWMIEEVWGIGVRIEGGSFTKRGTRSALEQVLSLDGSRTRMNERIEPLKELAHMAVEPNGSSDQDFKTLVDVVTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JGQ4</accession>
    <name>A0A118JGQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CheY-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARR family. Type-A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006558">
        <property type="protein sequence ID" value="KVH71664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JGQ4"/>
    <dbReference type="STRING" id="59895.A0A118JGQ4"/>
    <dbReference type="Gramene" id="KVH71664">
        <property type="protein sequence ID" value="KVH71664"/>
        <property type="gene ID" value="Ccrd_025595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF167">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH71664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="136" mass="14672" checksum="7DAC10F587D92803" modified="2016-04-13" version="1">MGVAAGSQFHVLAVDDSIINRKLIERLLKTSSFQVTTLDSGNMNSNQPFVSPNINQEVEVNLIIIDYCMPGMTGYDLLKKVKILLVKSNVAGSVAFLNAGLFFLLICQLAANDMGQDNDIGPTEHVGEQDNDTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRJ9</accession>
    <name>A0A118JRJ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005884">
        <property type="protein sequence ID" value="KVH87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRJ9"/>
    <dbReference type="STRING" id="59895.A0A118JRJ9"/>
    <dbReference type="Gramene" id="KVH87727">
        <property type="protein sequence ID" value="KVH87727"/>
        <property type="gene ID" value="Ccrd_024987"/>
    </dbReference>
    <dbReference type="OMA" id="VMKSARY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="102" mass="11762" checksum="AF14846AD0B88B1B" modified="2016-04-13" version="1">MGTKMDNAHQSDFMFCDICGTMLSFDSRNYIRCPLCKFKRKAIAIAGKEIKYTVSEEDYNVRCPKCSNKGVYYHTQQTRSADEGQTMFYNCPNCGYNFTDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS33</accession>
    <name>A0A118JS33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005560">
        <property type="protein sequence ID" value="KVH88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS33"/>
    <dbReference type="Gramene" id="KVH88122">
        <property type="protein sequence ID" value="KVH88122"/>
        <property type="gene ID" value="Ccrd_024489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="33" mass="3821" checksum="6CEC6F63435270A4" modified="2016-04-13" version="1">MLTLSKMLRHSHPSNLLLQRKLIVSIQLSVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSD2</accession>
    <name>A0A118JSD2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phospholipase A2</fullName>
            <ecNumber evidence="5">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_026752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01005400">
        <property type="protein sequence ID" value="KVH88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSD2"/>
    <dbReference type="STRING" id="59895.A0A118JSD2"/>
    <dbReference type="Gramene" id="KVH88466">
        <property type="protein sequence ID" value="KVH88466"/>
        <property type="gene ID" value="Ccrd_026752"/>
    </dbReference>
    <dbReference type="OMA" id="CQVDEVI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04706">
        <property type="entry name" value="PLA2_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000005">
        <property type="entry name" value="Secretory phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="17761" checksum="A6AA8E322F2E03C9" modified="2016-04-13" version="1">MLHLSVPFTSSMASLLHPLLFISFLTLYYSPISLFALKVNVGANTGVSLSKECSNKCESSFCKVPPLLRYGKYCGILYSGCPGEKPCDELDACCMKHDACIAANNNNYLSEECNKGLLGCVQRFKKAGSRTFKGNTCDVNDVTNTINLVMDAAVLAGRYIHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSI2</accession>
    <name>A0A118JSI2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005342">
        <property type="protein sequence ID" value="KVH88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSI2"/>
    <dbReference type="Gramene" id="KVH88736">
        <property type="protein sequence ID" value="KVH88736"/>
        <property type="gene ID" value="Ccrd_025859"/>
    </dbReference>
    <dbReference type="OMA" id="IPVYHQK"/>
    <dbReference type="OrthoDB" id="551907at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010158">
        <property type="term" value="P:abaxial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044847">
        <property type="entry name" value="KAN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31496:SF57">
        <property type="entry name" value="MYB DOMAIN, PLANT, HOMEODOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31496">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="40484" checksum="AE38D442614A693F" modified="2016-04-13" version="1">MEFFPAQPDLSLRISPPDTQPTSTTWRTSNPNDQDHDLDLGHFWKRALSSQNNHHGSTARSDTSFGLYFPYQTSHLNDSDLTQNMTNSTTNLQQYHHQKLSSELGLLTPIRGVPLYYQNTHPNFQILAQYHHQNNQTSSDSCITATSSSSASLIHGNSINNIARSRFLSSRFPAKRSVRAPRMRWTTTLHARFVHAVELLGGHERATPKSVLELMDVKDLTLAHVKSHLQMYRTVKTTDHKALLSTGQPEVFDNGSSGDNSYDIILGTENRRTELSTEHGGGRSSVYQDKEFQYGVWSNSSREALLHGKHGDFEANIPSLEKEMSSKGMKNERSSEVSSSSHSEARLKKPNLEFTLGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU90</accession>
    <name>A0A118JU90_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005073">
        <property type="protein sequence ID" value="KVH91149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU90"/>
    <dbReference type="STRING" id="59895.A0A118JU90"/>
    <dbReference type="Gramene" id="KVH91149">
        <property type="protein sequence ID" value="KVH91149"/>
        <property type="gene ID" value="Ccrd_006835"/>
    </dbReference>
    <dbReference type="OMA" id="PREICAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF246">
        <property type="entry name" value="3-ALPHA-(S)-STRICTOSIDINE BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="42853" checksum="D1265E8199231D07" modified="2016-04-13" version="1">MLDFNHTPLLDDDLKRQNFPSNFLFGVATSAYQVEGAWNADGKGLSICDCFALRNPDKISGGTNACVTVDSYSRMKVNISFCSFVNNYQEDVQLLKKMGVNSYRFSISWPRILPGGKVSMGKNQEGINYYNKLIDELLANGIEPFVTLFHWDLPNALEEEYMGFLSSKVVADFVDYVDICFWEFGDRVKNWLTLNEPHMFTYNGYVIGKFAPGRGENCKDSDVETEPYTVAYNLLNCHAAAYRKYEKDYKKSQKGKVGITLDLNFCKPYGGPSNDEDVKAVQYAYDFGNGWFLEPLVKGKWPENMQKFATTPTANYPKGRALPEFSADQRTKLIDSYDFLGINYYTSSYIQYRAPSVGIAPGYSTDCHFNASGNGKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVP6</accession>
    <name>A0A118JVP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVP6"/>
    <dbReference type="STRING" id="59895.A0A118JVP6"/>
    <dbReference type="Gramene" id="KVH92845">
        <property type="protein sequence ID" value="KVH92845"/>
        <property type="gene ID" value="Ccrd_005107"/>
    </dbReference>
    <dbReference type="OMA" id="ICNDNCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="313" mass="34826" checksum="42E0D542D5D4B7F9" modified="2016-04-13" version="1">MVTGGKSLKKFHDLICNDNCKDIKLTYFIMIFASVHFVLSHLPNFNSISGVSLAAAVMSLSYSIIAWSASVAKGVQPNVDYGYKSSTTADKIFNFFSALGDVAFAYAGHNVVLEIQATIPSTPEKPSKGPMWKGVVVAYIIVAICYFPVALIGYWIFGNEVSDNILISLEKPTWLIAMANLFVVIHVIGSYQIYAMPVFDMIETVLVKNLNFTPSFTLRFITRNLYVALTMFIGICFPFFGGLLGFFGGFAFAPTTYFLPCIMWLTIYKPKKWSLSWITNWICIVLGVALMIVSPIGGLRQIIVEAKDYEFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW00</accession>
    <name>A0A118JW00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAZY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004577">
        <property type="protein sequence ID" value="KVH94017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW00"/>
    <dbReference type="STRING" id="59895.A0A118JW00"/>
    <dbReference type="Gramene" id="KVH94017">
        <property type="protein sequence ID" value="KVH94017"/>
        <property type="gene ID" value="Ccrd_003914"/>
    </dbReference>
    <dbReference type="OMA" id="DWPNGLL"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009630">
        <property type="term" value="P:gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044683">
        <property type="entry name" value="LAZY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34045:SF12">
        <property type="entry name" value="NGR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34045">
        <property type="entry name" value="OS03G0406300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="234" mass="26534" checksum="0016E0F2C3B04628" modified="2016-04-13" version="1">MKIFSWMQSKLNAKQVTKKPDKIAANNHMAQATSKEEFSDWPHSLLAIGTFGISNLKADSESESQGPSQRYPQSPTPEELQEEEELNSYLETAESESLEPPSQSVCEERDIRLQRSISGMFSRGKDILMDPKNNVIRKKSLTFLLKNMFTSRSRFNHASFVRDSLPDPTLDKSRMEKVLRAILNKKIHPQSSTAKGMPKKYLGGKEISMGEDDEDDSEGSIWVKTDSEYIVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWT1</accession>
    <name>A0A118JWT1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004364">
        <property type="protein sequence ID" value="KVH96039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWT1"/>
    <dbReference type="STRING" id="59895.A0A118JWT1"/>
    <dbReference type="Gramene" id="KVH96039">
        <property type="protein sequence ID" value="KVH96039"/>
        <property type="gene ID" value="Ccrd_001880"/>
    </dbReference>
    <dbReference type="OMA" id="PAMVANH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000001">
        <property type="entry name" value="Probable aquaporin PIP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="29667" checksum="CEFA0FCB82FA718D" modified="2016-04-13" version="1">MSKEVSEVGETVRRDYVDPPPAPLMDMAELKLWSFYRALIAEFVATLLFLYITVATVIGYKNQSDPCGGVGLLGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLIRAVAYMVAQCLGAICGVGLVKAFMKSPYNSLGGGANSIAPGYNKGTALGAEIIGTFVLVYTVFSATDPKRSARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKVWDDQWIFWVGPFVGALAAAAYHQYILRAAAIKALGSFRSNATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXL3</accession>
    <name>A0A118JXL3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01003853">
        <property type="protein sequence ID" value="KVH97149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JXL3"/>
    <dbReference type="Gramene" id="KVH97149">
        <property type="protein sequence ID" value="KVH97149"/>
        <property type="gene ID" value="Ccrd_000763"/>
    </dbReference>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159785" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="163"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="571" mass="63433" checksum="9C8D9E0AB17BD219" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYG8</accession>
    <name>A0A118JYG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYG8"/>
    <dbReference type="STRING" id="59895.A0A118JYG8"/>
    <dbReference type="Gramene" id="KVH97449">
        <property type="protein sequence ID" value="KVH97449"/>
        <property type="gene ID" value="Ccrd_000427"/>
    </dbReference>
    <dbReference type="OMA" id="EESYQMM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="411"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH97449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="594" mass="67442" checksum="C717BF81026872F4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZD9</accession>
    <name>A0A118JZD9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteine peptidase, asparagine active site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_022457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003619">
        <property type="protein sequence ID" value="KVH99312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZD9"/>
    <dbReference type="STRING" id="59895.A0A118JZD9"/>
    <dbReference type="Gramene" id="KVH99312">
        <property type="protein sequence ID" value="KVH99312"/>
        <property type="gene ID" value="Ccrd_022457"/>
    </dbReference>
    <dbReference type="OMA" id="CDPAEKN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000057">
        <property type="entry name" value="Cysteine protease RD19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018588322" evidence="9">
        <location>
            <begin position="24"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="138"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH99312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="38771" checksum="80C40F821E4D23FF" modified="2016-04-13" version="1">MARFSLLFIFSLFLLISASVAVAVDDSASDPLIRQVVSEEETNADHLLNAEHHFTLFKSKFGRKYATPEEHEYRFSVFKSNLRRAKRHQLLDPTAEHGVTKFSDLTPSEFRKTYLGLKNPLTYPADANKAPILPTKDLPENFDWRDHGAVSGVKDQGSCGSCWSFSATGALEGSHFLQTGELVSLSEQQLVDCDHECDPAEKNSCDAGCNGGLMNNAFEYILNAGGIQKEADYPYTGKDGTCHFDKTKIAASVSNFSVVGTDEDQIAANLVKNGPLAISCPYICSKKRLDHGVLLVGYGAADYSPSRFKDKAYWIIKNSWGANWGEDGYYKICSGYNSCGMDTMVSAVVSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZM5</accession>
    <name>A0A118JZM5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003399">
        <property type="protein sequence ID" value="KVI00093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZM5"/>
    <dbReference type="Gramene" id="KVI00093">
        <property type="protein sequence ID" value="KVI00093"/>
        <property type="gene ID" value="Ccrd_021660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="40195" checksum="1BE2782FBD23521A" modified="2016-04-13" version="1">MASPHTPATSPSALSFSTDSDRHGRSKTGKAQMCLLKILRIISLFPAVDVSLKQRSSHGSXGSCENKEFDVDLNIGLGASKEIEPLEYPPLLATGGANCEDCVFTKNNRRKIDLFLEEKQEPVEEERTTENSEISHVGDQSSGIDCNGCSEEVGEKTRDEGYLDLLIEAAQLILGDECEPPSNKTETSFNYVESSTAAEKRGGTKRKKYCWTTTAYFIWTKAFCRFGDGSWIHFKVKCFHMHMDWNIFTSRSSMHPFGLSHSSVISLGKSVSIFRNSKYDVRAWTNMLGASADPSSDLKHFAFTQTSKQALCGSYTKFIFNNSCIKYSSTSTPLEWKKRWPNMSKKSLSNLVMVLGFLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Y9</accession>
    <name>A0A118K0Y9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003096">
        <property type="protein sequence ID" value="KVI01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Y9"/>
    <dbReference type="STRING" id="59895.A0A118K0Y9"/>
    <dbReference type="Gramene" id="KVI01441">
        <property type="protein sequence ID" value="KVI01441"/>
        <property type="gene ID" value="Ccrd_020289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="18954" checksum="33AE74FC3ED254F0" modified="2016-04-13" version="1">MAHVDHAFSISNEDTMTDSDSSYSQHNRPPVKEIGLAIALLIFGIVGVVSASSCPSIAGYAVNTGVLSYVDCLLRIQGYKGFSFSNIPPVYGFSIVESLRCSSVRSLGRQDLSNSFLGDRRARELLGTNVPSNLLVLPVPFEAPNLQIVSISTITSSIDMNDTYTIERFTLDNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1C3</accession>
    <name>A0A118K1C3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Forkhead-associated (FHA) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002649">
        <property type="protein sequence ID" value="KVI02613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1C3"/>
    <dbReference type="STRING" id="59895.A0A118K1C3"/>
    <dbReference type="Gramene" id="KVI02613">
        <property type="protein sequence ID" value="KVI02613"/>
        <property type="gene ID" value="Ccrd_019098"/>
    </dbReference>
    <dbReference type="OMA" id="QQAIWTF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000053">
        <property type="entry name" value="Os06g0275900 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="682" mass="75656" checksum="50AA8271AC9E3A74" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1H0</accession>
    <name>A0A118K1H0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic</fullName>
            <ecNumber evidence="4">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_019197</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[thioredoxin]-disulfide + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+) = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1H0"/>
    <dbReference type="STRING" id="59895.A0A118K1H0"/>
    <dbReference type="Gramene" id="KVI02476">
        <property type="protein sequence ID" value="KVI02476"/>
        <property type="gene ID" value="Ccrd_019197"/>
    </dbReference>
    <dbReference type="OMA" id="WDKCKEV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103012">
        <property type="term" value="F:ferredoxin-thioredoxin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="entry name" value="Ferredoxin thioredoxin reductase catalytic beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113">
        <property type="entry name" value="FERREDOXIN-THIOREDOXIN REDUCTASE CATALYTIC CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113:SF1">
        <property type="entry name" value="FERREDOXIN-THIOREDOXIN REDUCTASE CATALYTIC CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="Ferredoxin thioredoxin reductase (FTR), catalytic beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI02476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="25638" checksum="47F5EB510C506037" modified="2016-04-13" version="1" fragment="single">QNKAPWKQFIGSEKLISQPVVLHTSTAGQNQEHLSDTSSPALLGLIDRNRKSGVMTMMRALPASTSYAVGIRVSSFTTSPTHLASRRLVIAKAEPSDKSVEIMRKFSEQYARKSGTYFCVDKSVTSVVIKVLLFPTGLADHKDSLGAPLCPCRYMHNSCSFIYYVILFVNRHYDDKAAEATQGFWNCPCVPMRERKECHCMLFLTPENDFAGKEQIISMEEIKESTANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1K1</accession>
    <name>A0A118K1K1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_019092</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002649">
        <property type="protein sequence ID" value="KVI02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1K1"/>
    <dbReference type="STRING" id="59895.A0A118K1K1"/>
    <dbReference type="Gramene" id="KVI02611">
        <property type="protein sequence ID" value="KVI02611"/>
        <property type="gene ID" value="Ccrd_019092"/>
    </dbReference>
    <dbReference type="OMA" id="AIGFEGC"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.50:FF:000001">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000002">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012511">
        <property type="entry name" value="AdoMetDC_leader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF15">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08132">
        <property type="entry name" value="AdoMetDC_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <keyword evidence="9" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="44299" checksum="F7C6C0E5370D9CA5" modified="2016-04-13" version="1">MESKAGKKSSSSKSLFYEAPLGYGIEDVRPNGGLKKFKSAAYSNMAVEVSAIGFEGYEKRLEITFSDPGLFADPEGRGLRSLTKDQLDEILAPAECTIVSSLSNDSLDSYVLSESSLFVYPFKIIIKTCGTTKLLLSIPPILKLSSQLSLTVKSVRYTRGSFIFPGAQPFPHRSFTEEVTTLNGYFGSLGSGSKAYVMGGADKNQKWHVYSASSAETADHPVYTLEMCMTGLDKKHASVFYKNQSSSASMMTEVSGIRKILPNSQICDFEFDPCGYSMNAIESDAISTIHVTPEDGFSYASFEAVGYTFKSAVDLTLLVERVLACFQPNEFSVSLHGNDRRNLDLGSGNLNVKAYCVTETSFEDLGDGGGSMIYCLFTRGGNSCGSPRSTLHGCWSEYEDEELEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K285</accession>
    <name>A0A118K285_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002320">
        <property type="protein sequence ID" value="KVI03963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K285"/>
    <dbReference type="STRING" id="59895.A0A118K285"/>
    <dbReference type="Gramene" id="KVI03963">
        <property type="protein sequence ID" value="KVI03963"/>
        <property type="gene ID" value="Ccrd_017751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044842">
        <property type="entry name" value="ALKBH9B/ALKBH10B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31447">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31447:SF2">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23607" checksum="B8385A92CD0AE5CC" modified="2016-04-13" version="1">MIDRSLLVMRGNSADMARHVMCQSPTKRISITFFKVRIDDNNNNCDKSPMSPKDPMTGALTVWQPGVVPNGTLDGYDIIPKWGAIRAPQLLMLAPIRPMVMSPRRLPRGGTEASESSIPEEDARSESLPCTMNSAVDFSTPSIAEVPTSIDDGSSFTARLATSRNKSDSFLKPVPNSFRSRRSPKLHKPPPMPLPLPSSDELILEVESSSSSPSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2D8</accession>
    <name>A0A118K2D8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01002294">
        <property type="protein sequence ID" value="KVI04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2D8"/>
    <dbReference type="STRING" id="59895.A0A118K2D8"/>
    <dbReference type="Gramene" id="KVI04231">
        <property type="protein sequence ID" value="KVI04231"/>
        <property type="gene ID" value="Ccrd_017472"/>
    </dbReference>
    <dbReference type="OMA" id="DSASMIM"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF74">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25557">
        <property type="entry name" value="GAUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="535" mass="62165" checksum="D57BF6B8442C8D32" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2V9</accession>
    <name>A0A118K2V9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001898">
        <property type="protein sequence ID" value="KVI04938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2V9"/>
    <dbReference type="STRING" id="59895.A0A118K2V9"/>
    <dbReference type="Gramene" id="KVI04938">
        <property type="protein sequence ID" value="KVI04938"/>
        <property type="gene ID" value="Ccrd_016734"/>
    </dbReference>
    <dbReference type="OMA" id="RDCHNDP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN HEXBP-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="237" mass="26397" checksum="143080572FE77E58" modified="2016-04-13" version="1">MSRDRSRSPGLAKRFRSRDRAAYRDAPYRRDRPTYRHIAAECTSTTMCWNCKESGHLSSECPNDPVCHMCGKVGHLARDCHNPSVSSYDARLCNNCYKPGHIAADCTNEKACNNCRKTGHLARDCHNDPVCNICSISGHVARQCPKSGSDLPSLPGPLKHGSSSLMGPLGTSSMMDDPFRDMICRNCGRPGHISRDCVPMVICSNCGGRGHQEIECPSARIYDPFDRAFLDPRFRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3K0</accession>
    <name>A0A118K3K0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phox homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_015613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001853">
        <property type="protein sequence ID" value="KVI06045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3K0"/>
    <dbReference type="STRING" id="59895.A0A118K3K0"/>
    <dbReference type="Gramene" id="KVI06045">
        <property type="protein sequence ID" value="KVI06045"/>
        <property type="gene ID" value="Ccrd_015613"/>
    </dbReference>
    <dbReference type="OMA" id="SMSNHRK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000060">
        <property type="entry name" value="Phox (PX) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044588">
        <property type="entry name" value="EREX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856:SF3">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="504"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI06045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="747" mass="83984" checksum="1B543DE85FB73428" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4G8</accession>
    <name>A0A118K4G8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4G8"/>
    <dbReference type="STRING" id="59895.A0A118K4G8"/>
    <dbReference type="Gramene" id="KVI07513">
        <property type="protein sequence ID" value="KVI07513"/>
        <property type="gene ID" value="Ccrd_014083"/>
    </dbReference>
    <dbReference type="OMA" id="LCTCECK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF184">
        <property type="entry name" value="EXOSTOSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="6">
        <location>
            <begin position="131"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="501" mass="57160" checksum="0FA2972B41A9A8D9" modified="2016-04-13" version="1" fragment="single">MAGGRQYSSSSSMNPITKITRSPFLLALLSFLCFVLLFCIFSSSSPAKPISIHTSNTNQPHLNPNVEYSFVASLESFLSKRSIHGSRHLPDDTVGDSAAEEDQQVRRLDDLIWRTETARVYNDEKGSFFSPPLRVYVYEMPAKFTYDMLSLFQNTYKETFNLTSNGSPVHRLIEQHSIDYWLWADLIAPESERLLKSVVRVHRKEDADLFYVPFFTTISYFLLEKQQCKMLYREALKWIMDQPAWKRSEGRDHIFPIHHPWSFKSVRKYVKNAIWLLPDMDSTGNWYKPGQVSLEKDLILPYVPNLDLCDAKCLSESASKRTTLLYFRGRLKRNAGSAGEAGKIAAQSGMRKSVFCLSPAGDTPSSARLFDAIVSGCIPVIVSDELELPFEGILDYRRISLFVSSSDAVQPGWLLAYLRSIKPTQIREMQDNLAKYTRHFLYSHPAQPLGPEDLVWRMMAGKVANIKLHIRRSQRVVKESRSICMCDCKPPNITTTSLVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L6</accession>
    <name>A0A118K6L6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000986">
        <property type="protein sequence ID" value="KVI10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L6"/>
    <dbReference type="STRING" id="59895.A0A118K6L6"/>
    <dbReference type="Gramene" id="KVI10892">
        <property type="protein sequence ID" value="KVI10892"/>
        <property type="gene ID" value="Ccrd_010720"/>
    </dbReference>
    <dbReference type="OMA" id="QIQPAGN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47468">
        <property type="entry name" value="OS08G0130000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47468:SF1">
        <property type="entry name" value="OS08G0130000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="48172" checksum="951E88202FD92107" modified="2016-04-13" version="1">MVVTVWNSLMEEWWGSGEIFEEFVLEMGREMLNHEMDEEDLEAGSSTGVHQPQTRPFPTRYPGLVRLKAYRFDGFGDYCDKEWDLAEGSGKKVNSPGPASSKFTFRLAARITEHSVITVSLGRVPRLGFSPMGQSLLTEIPSVESPSPKFGRDETIERGGIVIKEHVLDFLLTMNHSEEADNPVPKSVSNLVVHVIDTHLDHLEDVVTKLEIELDSVEVDLDKGGFALKKQLLDDRRFPKMHLDLQRLLQSIAHGEQVFPRVKEKCSTKDWFSSEDINSLEELIGRLRRLKDNVGFISNRVTAVQAGLDSWQAEQINRKLYCLSFLSIIFLPLSIITGVFGMNVGGVPWTQQRDPKLKNGFRNVLLVCVATLVLVLLCFLFPFLYSRLTAWRRQRALKRSWSINHRSFLKRTIGGGERGGYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6R4</accession>
    <name>A0A118K6R4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000927">
        <property type="protein sequence ID" value="KVI11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6R4"/>
    <dbReference type="STRING" id="59895.A0A118K6R4"/>
    <dbReference type="Gramene" id="KVI11083">
        <property type="protein sequence ID" value="KVI11083"/>
        <property type="gene ID" value="Ccrd_010511"/>
    </dbReference>
    <dbReference type="OMA" id="PLYLKGH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47017">
        <property type="entry name" value="ACYL-COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47017:SF1">
        <property type="entry name" value="ACYL-COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="459" mass="52413" checksum="A1779AA67A108F97" modified="2016-04-13" version="1">MAMAMAMAVVRPSPFLGHIDFGLGGLSCRKQFPTPNQTSRIKALFWEPKKAADPPEMYLSLDSFTSTKINVKEDSSNAEKAKHISVSVVSSILEVPSGDWDECSLDATGPEQFNPFLSHGFLSSLEESGSAVKETGWLPRHIVAQDEDKNILGVIPLYLKSHSYGEYVFDHSWADAYYRYGSRYYPKLQCCVPFTPVPGPRILVRNTSNKNQVFDILVSAMKDLAIKFQVSSLHITFSSEHEWHALKDKGFLQRTGMQYHWKNRNYKNFDEFLMDMKQSKRKNIRQERKKIPAQNLTMKRLRGYEIKAKHWDTFYQFYRNTTDNKWGTAYLTREFFHIMGSKMGDHIMLIVAQEGDELVAGALNLIGGDTIYGRLWGCLPRVYYPSLHFEACYYQAIEAAIELNLDKVEAGAQGEHKIQRGYLPVTTYSSHYLLDEGFSQVKLVTELIKDSGPFKDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAK3</accession>
    <name>A0A124SAK3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005850">
        <property type="protein sequence ID" value="KVH87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SAK3"/>
    <dbReference type="Gramene" id="KVH87776">
        <property type="protein sequence ID" value="KVH87776"/>
        <property type="gene ID" value="Ccrd_024938"/>
    </dbReference>
    <dbReference type="OMA" id="DDTHRMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14871">
        <property type="entry name" value="uS7_Chloroplast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_uS7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="131" mass="14540" checksum="9E9F4AD9257CBE66" modified="2016-04-13" version="1">MLVNRILKXGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIHGVTPGIAVKARRVGGSTHQXPIEIXSTQGKALAIRWLLAASRKRPGRNMALKLSSELVDAAKGSGDAIRKREETHRMAEANRAFAHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAQ5</accession>
    <name>A0A124SAQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005495">
        <property type="protein sequence ID" value="KVH88240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAQ5"/>
    <dbReference type="STRING" id="59895.A0A124SAQ5"/>
    <dbReference type="Gramene" id="KVH88240">
        <property type="protein sequence ID" value="KVH88240"/>
        <property type="gene ID" value="Ccrd_024350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051980">
        <property type="term" value="F:iron-nicotianamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF11">
        <property type="entry name" value="METAL-NICOTIANAMINE TRANSPORTER YSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="24724" checksum="9297CDA74414929A" modified="2016-04-13" version="1">MAVVWEGWRQARAEVGETRAERIVSGGAISGGRRRRGVEGGGGGGGVVVEEKKVVVVDRYGGLKWWRGDKSLDEMPQEFNIEKMQLVEAEKKKIREEYERKQKQVEVRKKIFKEAATMDKIDNNSRSYFKHYFREHFLHCYSHEIESHKWDDSYLNVSAALLKSGISTVSFTRHENTMIQTCSVASYTIVIGGGFGSYFLALNKKTYEMARGANSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCY1</accession>
    <name>A0A124SCY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCY1"/>
    <dbReference type="STRING" id="59895.A0A124SCY1"/>
    <dbReference type="Gramene" id="KVH95212">
        <property type="protein sequence ID" value="KVH95212"/>
        <property type="gene ID" value="Ccrd_002667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF292">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="9">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="788" mass="90169" checksum="49D242414CF29CC7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEA3</accession>
    <name>A0A124SEA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003505">
        <property type="protein sequence ID" value="KVH99477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEA3"/>
    <dbReference type="STRING" id="59895.A0A124SEA3"/>
    <dbReference type="Gramene" id="KVH99477">
        <property type="protein sequence ID" value="KVH99477"/>
        <property type="gene ID" value="Ccrd_022288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47379">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47379:SF3">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14837" checksum="6D9819E01F9E08B2" modified="2016-04-13" version="1" fragment="single">MQPLEAPILNPIYLMLGASFGLAAKGTGLKPLEFALSICDILDMTRYFSQGHTPLQSRAYYQIMECLRLVKIHSPMRADPNHVVIWVPSHSSTTAARLASEKMLRYVVFTSCNSFCLVFSSQLAKNCIIRVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEW2</accession>
    <name>A0A124SEW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003119">
        <property type="protein sequence ID" value="KVI01336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEW2"/>
    <dbReference type="Gramene" id="KVI01336">
        <property type="protein sequence ID" value="KVI01336"/>
        <property type="gene ID" value="Ccrd_020403"/>
    </dbReference>
    <dbReference type="OMA" id="QMRNSAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="15785" checksum="14962608FE52D4C7" modified="2016-04-13" version="1">MAVLILINLIFSTIIMLSNLLSHLIFNTTAYLLVIAIQGLRVPGEALQSAMEQIADLIRTCIGYVLEVVMEVISEIVGLVFDLVKEGVFGSVSATGAATVGVVEKMKSGFDGLTEEIPAVVEGVVEMVTTVVSDLWNNYMNAQNYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF26</accession>
    <name>A0A124SF26_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB/POZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002672">
        <property type="protein sequence ID" value="KVI01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF26"/>
    <dbReference type="STRING" id="59895.A0A124SF26"/>
    <dbReference type="Gramene" id="KVI01908">
        <property type="protein sequence ID" value="KVI01908"/>
        <property type="gene ID" value="Ccrd_019799"/>
    </dbReference>
    <dbReference type="OMA" id="RKVDWSY"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18312">
        <property type="entry name" value="BTB_POZ_NPY3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51649">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NPH3" evidence="6">
        <location>
            <begin position="211"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="618" mass="68014" checksum="7DF24BCCDE2E7BC0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI55</accession>
    <name>A0A124SI55_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000067">
        <property type="protein sequence ID" value="KVI11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI55"/>
    <dbReference type="STRING" id="59895.A0A124SI55"/>
    <dbReference type="Gramene" id="KVI11626">
        <property type="protein sequence ID" value="KVI11626"/>
        <property type="gene ID" value="Ccrd_009964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="28786" checksum="69128B84D46248B2" modified="2016-04-13" version="1">MLKGFRSRVAALRPQGPIATRFSSKNLTVVVVGESLPLRSRTKNEQEKFKKDFSSGSGSGSGSGSSFGAEKGIQFLGLLGGKQPQDQWLVRLLPKGQVILNHLLVVQHYHEVCYDYAPGVSSQLFLLVFVEDPTVFEEEATSAPETFEISAAKVAIFFLLPESVAGETLTPLDNLLPGDIDILLELGDACFRPVGEGCLYLEGTMIAGSLAAFRFSSLATTKLGTTHFEGTGDDDLFTFPAGEGSLSTTFFFPADTGLCCFIPGLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5I1</accession>
    <name>A0A103D5I1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aluminum-activated malate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024127</name>
        <name evidence="10" type="ORF">Ccrd_024128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aromatic acid exporter (TC 2.A.85) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011558">
        <property type="protein sequence ID" value="KVD98174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01011557">
        <property type="protein sequence ID" value="KVD98175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5I1"/>
    <dbReference type="STRING" id="59895.A0A103D5I1"/>
    <dbReference type="Gramene" id="KVD98174">
        <property type="protein sequence ID" value="KVD98174"/>
        <property type="gene ID" value="Ccrd_024128"/>
    </dbReference>
    <dbReference type="Gramene" id="KVD98175">
        <property type="protein sequence ID" value="KVD98175"/>
        <property type="gene ID" value="Ccrd_024127"/>
    </dbReference>
    <dbReference type="OMA" id="HTIRCHR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVD98174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVD98175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="407" mass="45703" checksum="D1282FBA4B0F2AB0" modified="2016-04-13" version="1" fragment="single">MEPLFKGVGQNAIWAVMTVVVVLEFTAGATLCKGLNRGFGTLLAASLAFFFEFIAREYGKVFRAVFIGASIFLIGALTTYLRFFPNIKKNYDYGVLIFLLTFNLITVSSYRVDDILKLAQGRIYTIAIGSGVCILMSLFIFPNWSGEDLHNSTVSKIEGLARSIEACVVKYFNDEEPDLEIDETTEDPIYNNYKAVLDSKSTDETLARHASWEPRHSWHCHKFPWQQYVKLGGVLRHFGYAIVALHGSLQTEIRTPRSVRLLFKEPCIRLVSEVTKALMELADSIRNRRHCSPEILTDHLHRALQDLDTALKSQPRLFLGPNSPNNTAKMLAVVAATARQKSEKHLSGLKTDSPRFLDRISEGERRVLRPTLSKLAITSLEFSEALPFAAFVALLVESVARLDVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103I2A0</accession>
    <name>A0A103I2A0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009925">
        <property type="protein sequence ID" value="KVF00324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103I2A0"/>
    <dbReference type="Gramene" id="KVF00324">
        <property type="protein sequence ID" value="KVF00324"/>
        <property type="gene ID" value="Ccrd_026874"/>
    </dbReference>
    <dbReference type="OMA" id="EMESVTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF585">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF00324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18763" checksum="BA3038E842D0A183" modified="2016-04-13" version="1" fragment="single">METSPYEGCRIVRLGSFRSLDLKTDSLTKMDNLKLLHLNDVHLTGSYEDFSEDLRWLCWRQFDLRAIPSGLFFKSLVAIDMRDSKLKVLPLLKTLNLQSSKSLSAIRSIYRLPNIETLLLCQCYELVDVCKTIGDLMNLALLDMSECPKLNRKLIRFSSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103KFL2</accession>
    <name>A0A103KFL2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009334">
        <property type="protein sequence ID" value="KVF52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103KFL2"/>
    <dbReference type="STRING" id="59895.A0A103KFL2"/>
    <dbReference type="Gramene" id="KVF52364">
        <property type="protein sequence ID" value="KVF52364"/>
        <property type="gene ID" value="Ccrd_026755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF436">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11355" checksum="F30E63F998C256F0" modified="2016-04-13" version="1" fragment="single">LDEYRKNFSDSWKAVQADCSQAWPYLDEALTKFQSGCWKVGVDLFHYMLEMDAKFDEVTLISVLTACGRVGALELGEWIKEYIEANRLKGNATLVTALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103QB30</accession>
    <name>A0A103QB30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008126">
        <property type="protein sequence ID" value="KVG45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103QB30"/>
    <dbReference type="Gramene" id="KVG45952">
        <property type="protein sequence ID" value="KVG45952"/>
        <property type="gene ID" value="Ccrd_026407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="7635" checksum="96943A5D46215D78" modified="2016-04-13" version="1">MYASPALSTSSKPFLITTFCIQYNLIKAPTSESGSITNQLCLSLTLNYEEEQVKREDSTKEQPSQMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103T9T1</accession>
    <name>A0A103T9T1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) kinase</fullName>
            <ecNumber evidence="3">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_025952</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in chlorophyll synthesis and chloroplast protection against oxidative damage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01007163">
        <property type="protein sequence ID" value="KVH11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103T9T1"/>
    <dbReference type="STRING" id="59895.A0A103T9T1"/>
    <dbReference type="Gramene" id="KVH11580">
        <property type="protein sequence ID" value="KVH11580"/>
        <property type="gene ID" value="Ccrd_025952"/>
    </dbReference>
    <dbReference type="OMA" id="DCEASDM"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000019">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055214">
        <property type="entry name" value="PTP-NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF6">
        <property type="entry name" value="NAD KINASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22741">
        <property type="entry name" value="PTP-NADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DSP-PTPase phosphatase fused to NAD+ Kinase" evidence="16">
        <location>
            <begin position="248"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="961" mass="107995" checksum="A7468B2D2E5A6458" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103V0P5</accession>
    <name>A0A103V0P5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat, cysteine-containing subtype</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006818">
        <property type="protein sequence ID" value="KVH45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103V0P5"/>
    <dbReference type="STRING" id="59895.A0A103V0P5"/>
    <dbReference type="Gramene" id="KVH45299">
        <property type="protein sequence ID" value="KVH45299"/>
        <property type="gene ID" value="Ccrd_025733"/>
    </dbReference>
    <dbReference type="OMA" id="ESEHNEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF2">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20183" checksum="727F39F896BD8081" modified="2016-04-13" version="1">MTRGLTQVLKRLPHLETLHLVNISIHSDDIEVIGRSCPQLKSFMKKTHYIEYGADALAIANNMAALHHLQLFGCAIPDDCLHPILHGCPHLESFDICGCFYLLLDGNLEEMCIERIKDFKFMLYNLPIDKYEFSDIDLYDYKDCDSSAMDLSDYEDYEFSGSSAISAEEDSDYYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103W4E9</accession>
    <name>A0A103W4E9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_025631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01006618">
        <property type="protein sequence ID" value="KVH65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103W4E9"/>
    <dbReference type="STRING" id="59895.A0A103W4E9"/>
    <dbReference type="Gramene" id="KVH65603">
        <property type="protein sequence ID" value="KVH65603"/>
        <property type="gene ID" value="Ccrd_025631"/>
    </dbReference>
    <dbReference type="OMA" id="FWLVEYD"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000016">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000012">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000020">
        <property type="entry name" value="Aspartokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="194"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="345" mass="38154" checksum="524393CBBA28E60E" modified="2016-04-13" version="1">MTRSQFFINISCLFWQYDAFDIGFITTDDLTNADILEATYPAVAKRLHGDWIKDPAIPIVTGFLGKGWRTCAVTTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPNIYSGAEPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGDIPVRVKNSYNPNAPGTLITKSRDMSKAVLTSIVLKRNVTMLDIVSTRMLGQFGFLAKVFSIFEDLGISVDVVATSEVSISLTLDPSKLWNRELIQQASELDHVVEELEKIAKVNLLQHRSIISLIGNVQRSSLVLEKAFRVLRMNSVNVQMISQGASKVNISLIVNDSEAERCVKALHSAFFEEDDISDMDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBI8</accession>
    <name>A0A103XBI8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_025034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family. SR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005934">
        <property type="protein sequence ID" value="KVH87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBI8"/>
    <dbReference type="STRING" id="59895.A0A103XBI8"/>
    <dbReference type="Gramene" id="KVH87683">
        <property type="protein sequence ID" value="KVH87683"/>
        <property type="gene ID" value="Ccrd_025034"/>
    </dbReference>
    <dbReference type="OMA" id="RHPMLRH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12599">
        <property type="entry name" value="RRM1_SF2_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12602">
        <property type="entry name" value="RRM2_SF2_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000062">
        <property type="entry name" value="serine/arginine-rich splicing factor SR34A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000244">
        <property type="entry name" value="serine/arginine-rich splicing factor SR34A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="242"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="43522" checksum="ED3F13C2C9960D94" modified="2016-04-13" version="1">MAIGEISAVHLRSPSIINTLGAGVSAIRLGAERSLFLRLLLLLQMESAWTNMSYGTIHRDVNGVWEESVSSQAVEHLGAYEHRSLWSTAHHEDCSIGLLHSFVLVNFVIVFHLEAVKNFIQDQKMSGRFSRTIYVGNLPLDIREWEVEDLFYKYGRILDIELKIPPRPPCYCFVEFESSRDAEDAIRGRDGYNFDGCRLRVELAHGGRGQSSSSDRRGDYGGGRSSGGGGAGRFGISRHSEYRVIVRGLPSSASWQDLKDHMRKAGDVCFAEVSRDSDGTFGLVDYTNYEDMKYAIRKLDDTEFRNPWTKTYIRVRRYDRSPSRSPSRSRSRSRSLGRSRSRSNSLERSVSKSPSKSRSASPVKPSRARSRSRSESPRPRQVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCQ9</accession>
    <name>A0A103XCQ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005447">
        <property type="protein sequence ID" value="KVH88335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCQ9"/>
    <dbReference type="STRING" id="59895.A0A103XCQ9"/>
    <dbReference type="Gramene" id="KVH88335">
        <property type="protein sequence ID" value="KVH88335"/>
        <property type="gene ID" value="Ccrd_024111"/>
    </dbReference>
    <dbReference type="OMA" id="NCETWVL"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="296" mass="34652" checksum="915D7143417BF5E9" modified="2016-04-13" version="1">MRLESIYISEMNNQDQHKFLPKRIILVRHGESAGNLDGSAYTTTPDYKIPLTPDGIAQAKLAGTQIRDVISDSGKLRNWKVCLYVSPYERTRSTLREIGRSFPRKRVIGVREECRIREQDFGNFQITERMKVIKETRERFGRFFYRFPEGESAADVFDRVSSFLESLWRDIDSRLHYDPSDDLNIIIVSHGLASRVFLMKWFKWTVEQFEYLNNFNNCEFRVMQLGDGGEYSLAVYHSDEEMQEWGLSAEMIADQKCRANATRGVMMEKCPWYLDHFFDHLDTDSDDNEDAKKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDS5</accession>
    <name>A0A103XDS5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_024893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005327">
        <property type="protein sequence ID" value="KVH88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDS5"/>
    <dbReference type="SMR" id="A0A103XDS5"/>
    <dbReference type="STRING" id="59895.A0A103XDS5"/>
    <dbReference type="Gramene" id="KVH88891">
        <property type="protein sequence ID" value="KVH88891"/>
        <property type="gene ID" value="Ccrd_024893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118700" evidence="3">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15786" checksum="EA492250AF0803AE" modified="2016-04-13" version="1">MESSSSFLFTTLFFSLCVCSLISTTKFDQLFQPYCAADHFSFNGEALNMKLDNCSGAGFWSKSKYMFGKFNIQIKLVEGDFAGTVAAFYMSSDGPKHHEFDFEFLGNTIGEPCFGLSICEPFFLSFASSVPVFKVAFFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDW2</accession>
    <name>A0A103XDW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005325">
        <property type="protein sequence ID" value="KVH88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDW2"/>
    <dbReference type="Gramene" id="KVH88950">
        <property type="protein sequence ID" value="KVH88950"/>
        <property type="gene ID" value="Ccrd_024679"/>
    </dbReference>
    <dbReference type="OMA" id="RQACHSR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF587">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118710" evidence="5">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="38760" checksum="B96B8844816AA68C" modified="2016-04-13" version="1">MESGRRKTLVPSLLFLLILIISLSNQSLILNATIITKCHFPAIFNFGDSNSDTGGLSAAFGQAPPPNGETFFHRPAARYSDGRLLIDFIAQRVGLAYLGAYLDALGSNFTAGANFATGGSTIRPQNTSRHQTFSHGLYTFDIGQNDLTGGLLLNLSIDQVKASVPDILGQFKTVVKDVYDKEGGRSFWIHNTGPIGCLPYVLEHLPIRAGQMDINGCANPFNELAQFFNRRLKELVGQLRKELPEAAITYVDIYKARYALISQASKYGFDHPLRACCGYGGKYNYNTHIGCGGKVENKGKEILVGKSCEDPSVKIIWDGIHYTEAANKWVFDRIVNGSFSDPSVPLQMACHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE33</accession>
    <name>A0A103XE33_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_008982</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005320">
        <property type="protein sequence ID" value="KVH89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE33"/>
    <dbReference type="STRING" id="59895.A0A103XE33"/>
    <dbReference type="Gramene" id="KVH89030">
        <property type="protein sequence ID" value="KVH89030"/>
        <property type="gene ID" value="Ccrd_008982"/>
    </dbReference>
    <dbReference type="OMA" id="YIMPPIM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16571">
        <property type="entry name" value="RING-HC_SIAHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052088">
        <property type="entry name" value="E3_ubiquitin-ligase_SINA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315">
        <property type="entry name" value="E3 UBIQUITIN PROTEIN LIGASE SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315:SF80">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="318" mass="35997" checksum="E092F844831FBB38" modified="2016-04-13" version="1">MEIDNIECVSVSDGLIDDAIPHHNHHHHRPPHPHPHPHPHQNNPNPNPNPNPNPNPQFSSSKTHNVNVVPSTIHPTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKARVHNRCPTCRQELGDIRCLALEKVAESLELPCKYCSLGCPGIFPYYSKLKHEAVCNFRPYSCPYAGSECSVVGDIPYLVSHLRDDHKVFNCFGQYFCLHFEAFQLSMAPVYMAFLRFMGDENDARNYRYSLEVGGNGRKLIWEGTPRSIRDGHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEPPNSDGSNVCIPNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFN3</accession>
    <name>A0A103XFN3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_008104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005126">
        <property type="protein sequence ID" value="KVH89899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFN3"/>
    <dbReference type="STRING" id="59895.A0A103XFN3"/>
    <dbReference type="Gramene" id="KVH89899">
        <property type="protein sequence ID" value="KVH89899"/>
        <property type="gene ID" value="Ccrd_008104"/>
    </dbReference>
    <dbReference type="OMA" id="QTASMNT"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000071">
        <property type="entry name" value="probable ADP,ATP carrier protein At5g56450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF31">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH89899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="36731" checksum="4294A65B7A318DF9" modified="2016-04-13" version="1">MVVEGKGEESVSSESKSDETEMTTMSSYWLINFPRDLMAGAFMGGIVHSIVAPIERAKLLLQTQESNIAIIGGKHRRFKGMIDCIVRTVKEEGIISLWRGNGSSVLRYYPSVALNFSLKDLYRSILRNDNFQTSNNFFSGPSANFIAGAAAGCTTLVIIYPLDIAHTRLAADLGRTESRQFQGIRHFLSTVRAKEGIRGIYQGLPASLHGMVVHRGLYFGGFDTIKEKMSENTVSEVSLWNRWIVAQGVTTVAGLLSYPLDTVRRRMMMQSGSDDRMYRSTLDCWKKIYKEGGIGSFYRGAVSNIFRSTGAAAILVLYDEVKKLMEWSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGU5</accession>
    <name>A0A103XGU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGU5"/>
    <dbReference type="STRING" id="59895.A0A103XGU5"/>
    <dbReference type="Gramene" id="KVH90439">
        <property type="protein sequence ID" value="KVH90439"/>
        <property type="gene ID" value="Ccrd_007583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="13831" checksum="17244D23ADF2A5CF" modified="2016-04-13" version="1">MSTSSGPYDLSFKILLIGDSGVGKSSLLVSFISNSVNDLPPTIGVDFKLKQLRVGGKRLKLTIWDTEELNHAREGLGAELYKQCIKTRMKGHSSVFLMMSCCSRTGEIQDIDKLVLQRYPRDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHD4</accession>
    <name>A0A103XHD4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005091">
        <property type="protein sequence ID" value="KVH90810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHD4"/>
    <dbReference type="STRING" id="59895.A0A103XHD4"/>
    <dbReference type="Gramene" id="KVH90810">
        <property type="protein sequence ID" value="KVH90810"/>
        <property type="gene ID" value="Ccrd_007175"/>
    </dbReference>
    <dbReference type="OMA" id="NIFIWII"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF103">
        <property type="entry name" value="LEUCINE-RICH RECEPTOR-LIKE KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118788" evidence="10">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="11">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="12">
        <location>
            <begin position="98"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="26010" checksum="71573247CE6C6E3E" modified="2016-04-13" version="1">MIWFYFVLISMLLLCPNTTILATCSSIGNQSAAATDGNYGGINKSCFHKEKQALLHFKASLRDPLGQLSTWRPAEDDDCCKWSGVTCNNHTGHVTELNLHSYHLRGEISPSLLNLTYLNHLDLCFNSFDGTIPKVITSMTQLRYLDLSFNFFHGTIPRSIGSLTQLRYLDLSFNFFNGTILPEFGNLTNLRNLSLGNNERLSTIQTLDWLSNLSHLQHLDMTHISLANATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHL0</accession>
    <name>A0A103XHL0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EMSY N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHL0"/>
    <dbReference type="STRING" id="59895.A0A103XHL0"/>
    <dbReference type="Gramene" id="KVH90873">
        <property type="protein sequence ID" value="KVH90873"/>
        <property type="gene ID" value="Ccrd_007146"/>
    </dbReference>
    <dbReference type="OMA" id="AITWEME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.40:FF:000005">
        <property type="entry name" value="ENT domain containing protein, expressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.40">
        <property type="entry name" value="ENT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033485">
        <property type="entry name" value="EMSY-LIKE_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005491">
        <property type="entry name" value="ENT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036142">
        <property type="entry name" value="ENT_dom-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33432:SF27">
        <property type="entry name" value="PROTEIN EMSY-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33432">
        <property type="entry name" value="PROTEIN EMSY-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03735">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01191">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158639">
        <property type="entry name" value="ENT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51138">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENT" evidence="4">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="41768" checksum="ECCBADD8FAF89446" modified="2016-04-13" version="1">MITAGTDDDLPPPHQNKFRSGGPGTGNGRTMAVGNAPFPRIQNDMETQIHLIEQEAYSSVLRAFKAQSDAITWEMESLITDLRKELRVSDEEHRKLLSKVNADDIIRRIREWRKTNGLQPGMLNSPTASASRKKQKTSQSGPSLSVGPPPPALHQPMPPSSSALNRCPGSGMRGKKPQSYGSAGFTGRDQVPKQGFGGAFSANGVDEDNSSDPLIGRKGRHALVYDANTPNEAWEWVNLREISPNDIRWKWEDVGISHRGGRSGSSRGMKNPTARGGTTAGSGRGRVISKGHSSKADPMDIEKARKVLKDHEQALVDAIAKLEGTSDGESDREDRDQLSHLQKQSVEMGKISRKHEVGEGSDGNKVAMETRDGLNQPNGGQDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI48</accession>
    <name>A0A103XI48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005074">
        <property type="protein sequence ID" value="KVH91143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI48"/>
    <dbReference type="Gramene" id="KVH91143">
        <property type="protein sequence ID" value="KVH91143"/>
        <property type="gene ID" value="Ccrd_006842"/>
    </dbReference>
    <dbReference type="OMA" id="KEGRTTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994:SF5">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="217" mass="24228" checksum="2AD881540208D089" modified="2016-04-13" version="1">MRCISKAFRISGHHMLPHRWAAIAAQMPGRTDNEIKNLWNTHLRKRLLSIGIDPQTHEPTSVSSPSVGPLKRPSASPSTRHMAQWESARMEAEARLSMESSASVSVLLSSPNKSTTSTDYFLRIWHSEVGESFQNLNKGKMGCFSPASQTSESNTTIETEPKPYREPEPRLDGVTFCQGFTRASSPCEMEDSSDTSLQLFFDFAGLNDMSFLEAHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI59</accession>
    <name>A0A103XI59_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endoribonuclease Dicer homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Dicer-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Ccrd_006913</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 20">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005081">
        <property type="protein sequence ID" value="KVH91073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XI59"/>
    <dbReference type="Gramene" id="KVH91073">
        <property type="protein sequence ID" value="KVH91073"/>
        <property type="gene ID" value="Ccrd_006913"/>
    </dbReference>
    <dbReference type="OMA" id="CGFHKYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19869">
        <property type="entry name" value="DSRM_DCL_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02844">
        <property type="entry name" value="PAZ_CAF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000005">
        <property type="entry name" value="Endoribonuclease Dicer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000032">
        <property type="entry name" value="endoribonuclease Dicer homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000420">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000007">
        <property type="entry name" value="Endoribonuclease dicer-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000705">
        <property type="entry name" value="Endoribonuclease dicer-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF78">
        <property type="entry name" value="RIBONUCLEASE III POST-TRANSCRIPTIONAL GENE SILENCING PAZ-ARGONAUTE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="279"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="690"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="27">
        <location>
            <begin position="889"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="24">
        <location>
            <begin position="1199"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="23">
        <location>
            <begin position="1375"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="23">
        <location>
            <begin position="1573"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="22">
        <location>
            <begin position="1747"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="22">
        <location>
            <begin position="1833"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KVH91073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1908" mass="214508" checksum="69D832C7DBAF316E" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI65</accession>
    <name>A0A103XI65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005070">
        <property type="protein sequence ID" value="KVH91200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI65"/>
    <dbReference type="STRING" id="59895.A0A103XI65"/>
    <dbReference type="Gramene" id="KVH91200">
        <property type="protein sequence ID" value="KVH91200"/>
        <property type="gene ID" value="Ccrd_006786"/>
    </dbReference>
    <dbReference type="OMA" id="NQNIFIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF436">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="23934" checksum="63C6BBA860DF6A2B" modified="2016-04-13" version="1">MLTSNQQPWNSALPTLVHLPNCKTQFDINQIHARLLTTGFIKNSYLTTKLILCFSSSPHTPLIRFARHIFFSHSSSWSSKTDDPFLWNAVIKTFSHGNHGDDPKQAVFVLGLMLENGACVDKFSFSLVLKACSRMGLIREGIQIHGFLEKVGFASDLYLQNCLICMYVKCGWVEFARQVFDRMPQRDSISFNSMIDGYIKCGMVTLARELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI74</accession>
    <name>A0A103XI74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-glucuronate 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_006782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate</text>
            <dbReference type="Rhea" id="RHEA:11404"/>
            <dbReference type="ChEBI" id="CHEBI:57635"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="5.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.6" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01005070">
        <property type="protein sequence ID" value="KVH91204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI74"/>
    <dbReference type="STRING" id="59895.A0A103XI74"/>
    <dbReference type="Gramene" id="KVH91204">
        <property type="protein sequence ID" value="KVH91204"/>
        <property type="gene ID" value="Ccrd_006782"/>
    </dbReference>
    <dbReference type="OMA" id="WSIVFFC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050378">
        <property type="term" value="F:UDP-glucuronate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000198">
        <property type="entry name" value="UDP-glucuronate 4-epimerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="13">
        <location>
            <begin position="105"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH91204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="450" mass="50422" checksum="03AF8145433394EA" modified="2016-04-13" version="1">MKSSHLDNIPSTPGKFKIEKSPYSHRFRWHYSYLAKLTFWSFVFLALIFIFFFKSPPSSSPYSSISTTPSDLSRRSLKTSSWGGPAWEKRVRSSAKVRSKTGFSVLVTGAAGFVGTHVSASLKRRGDGVLGLDNFNDYYDPYLKRARQALLERSGIYIVEGDINDVALLKKLFEVIPFTHVMHLAAQAGVRYAMENPNSYIHSNVAGFVNLLEVCKSANPQPAIVWASSSSVYGLNTKVPFSEKDRTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFFTVYGPWGRPDMAYFFFTRDILKGKAIPIFESANHGTVARDFTYIDDIVKGCLGALDTAEKSTGSGGKKKRPAQLRVFNLGNTSPVPVSDLVSILEKLLKVKAKRRVMKLPRNGDVPFTHANISFAQREFGYKPTTDLQMGLKKFVRWYGGFDLYQKELKKDLDSWECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJR5</accession>
    <name>A0A103XJR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004864">
        <property type="protein sequence ID" value="KVH92056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJR5"/>
    <dbReference type="STRING" id="59895.A0A103XJR5"/>
    <dbReference type="Gramene" id="KVH92056">
        <property type="protein sequence ID" value="KVH92056"/>
        <property type="gene ID" value="Ccrd_005916"/>
    </dbReference>
    <dbReference type="OMA" id="ECKKINF"/>
    <dbReference type="OrthoDB" id="1885001at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF7">
        <property type="entry name" value="DUF538 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15880" checksum="B8E3F27EFAAAB88D" modified="2016-04-13" version="1">MASQHIEIESHRQNAQVYTGEAICKEKTQEVLAKFSLPKGLIPMNDVTEVGHNASTGFVWVRRKKKTNHLFRAIGRKVSYDSEVTAVIEDRRMRNLTGVKSKELLIWVTISDICINDSGKITFGTPAGLSRTFPASAFEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKX7</accession>
    <name>A0A103XKX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004809">
        <property type="protein sequence ID" value="KVH92690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKX7"/>
    <dbReference type="STRING" id="59895.A0A103XKX7"/>
    <dbReference type="Gramene" id="KVH92690">
        <property type="protein sequence ID" value="KVH92690"/>
        <property type="gene ID" value="Ccrd_005269"/>
    </dbReference>
    <dbReference type="OMA" id="WFFFCIR"/>
    <dbReference type="OrthoDB" id="1424968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000006">
        <property type="entry name" value="NAC domain-containing protein 100-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF202">
        <property type="entry name" value="NAC DOMAIN CONTAINING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="35114" checksum="B54AEC0CF606D23B" modified="2016-04-13" version="1">MDHKFDHEEHIELPPGFRFHPTDEELISHYLYPKVSDHTFSARAIGEVDLNKVEPWELPWRAKLGEQEWFFFCIRDRKYPTGSRTNRATDAGYWKATGKDKEIYKEKSLVGMKKTLVFYKGRAPKGEKTDWVMHEYRLDGKFSANNLPKSSKGEWVISRVFHKCAGGKKIPISGLSKDFGSANLPPLMEISSFEGGSSRTETSHVTCFSESMEEQKPNNQELVGSWSSSKTSLMASRNETANFPNPLVQNLDNFQYQDSIWMQDSSILKILIESNNDSVMRQNPKTELVDDQDYGLNSDFDLWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM71</accession>
    <name>A0A103XM71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004786">
        <property type="protein sequence ID" value="KVH93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM71"/>
    <dbReference type="STRING" id="59895.A0A103XM71"/>
    <dbReference type="Gramene" id="KVH93274">
        <property type="protein sequence ID" value="KVH93274"/>
        <property type="gene ID" value="Ccrd_004673"/>
    </dbReference>
    <dbReference type="OMA" id="YTTMGPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31722:SF71">
        <property type="entry name" value="GENOME ASSEMBLY, CHROMOSOME: A05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31722">
        <property type="entry name" value="OS06G0675200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="14252" checksum="CA8C9E4307F249BA" modified="2016-04-13" version="1">MKKEKGLFMGPRISFSNDFVESKNHHENMSYREAPVSSDFEFCVPSFSANSADEVFFKLPPLKEMNSKVTLRDELLAGGDDDDGYNSCKNSSSGTRWWREKFRLRKSQHKNHGVIWRLMEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMT7</accession>
    <name>A0A103XMT7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Conserved oligomeric Golgi complex subunit 8</fullName>
            <shortName evidence="9">COG complex subunit 8</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004718">
        <property type="protein sequence ID" value="KVH93608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMT7"/>
    <dbReference type="STRING" id="59895.A0A103XMT7"/>
    <dbReference type="Gramene" id="KVH93608">
        <property type="protein sequence ID" value="KVH93608"/>
        <property type="gene ID" value="Ccrd_004339"/>
    </dbReference>
    <dbReference type="OMA" id="QRCIHGV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016632">
        <property type="entry name" value="COG8_Metazoal_Plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015415">
        <property type="entry name" value="COG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="550" mass="61873" checksum="F0FBAF1F478DBC06" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNS2</accession>
    <name>A0A103XNS2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004576">
        <property type="protein sequence ID" value="KVH94055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNS2"/>
    <dbReference type="Gramene" id="KVH94055">
        <property type="protein sequence ID" value="KVH94055"/>
        <property type="gene ID" value="Ccrd_003883"/>
    </dbReference>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001953">
        <property type="entry name" value="PRK00733.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001960">
        <property type="entry name" value="PRK00733.3-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="843" mass="89154" checksum="7AAD571DDDE5781B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPE4</accession>
    <name>A0A103XPE4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPE4"/>
    <dbReference type="STRING" id="59895.A0A103XPE4"/>
    <dbReference type="Gramene" id="KVH94259">
        <property type="protein sequence ID" value="KVH94259"/>
        <property type="gene ID" value="Ccrd_003647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="39499" checksum="E9B23E811AFB8DC7" modified="2016-04-13" version="1">MDHVVGGKFKLGRKIGSGSFGELYLGVNIQSGEEVAIKLVLTSILDHSGIPNLKWFGVETEYNIMVIDLLGPSLEDLFNYCSRKFTLKTVLMLADQLINRVEYMHARGFLHRDIKPDNFLMGLGRKANQVYVIDFGLAKKYRDLQTHKHIPYSLPWQGLKAGNKKQKYDKISEKKMFTPIEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGVNAGTSAEKPGRTSAGQDIRDRVLGAVEVFSRRNSSKDVQPDSEKLRSSRNGDSSKRAAIAGGRPTSSGEATEGRLTRHVSSSAGRLSTTHRVQPGYDTKLSGFSRTAKGGGHDDALRSLEFLSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPU0</accession>
    <name>A0A103XPU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004535">
        <property type="protein sequence ID" value="KVH94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPU0"/>
    <dbReference type="Gramene" id="KVH94682">
        <property type="protein sequence ID" value="KVH94682"/>
        <property type="gene ID" value="Ccrd_003253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008">
        <property type="entry name" value="LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-LIKE 1.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008:SF48">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="121"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="39160" checksum="AFFCC72723B1F5A8" modified="2016-04-13" version="1">MNQSRNSPVIRSAPGQVWNQSSSSTSNSGSIYGFRRDHQPIEQKKTSFFGLIVRVLTCKGDIAHVDEGHPQPATVPYSNPASLKSSKKHDSASSTPSVASNGQQGSNGLSFEDIRKATGDFSTSNIIGEGGFGTVYKGTLKNGSIIAIKRVKKETYDRGTPVEFKNEILTFSKIEHLNLVRFYGYIEHGDERIILVEYVSNGTLRDHLDGKCSYMYPVYTRVQRSCRKCGSGLETGERLDIMIDAMQRLKGGEVVLAMDPKLRRNPASMMVVEKVLRLARQCLAPTRQLRPSMKRCAEILWRIRKDFHEHKDVMAAAIHSVQVPQMDARKNRREFFGIEDSNNQRFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPZ4</accession>
    <name>A0A103XPZ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_003161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPZ4"/>
    <dbReference type="STRING" id="59895.A0A103XPZ4"/>
    <dbReference type="Gramene" id="KVH94776">
        <property type="protein sequence ID" value="KVH94776"/>
        <property type="gene ID" value="Ccrd_003161"/>
    </dbReference>
    <dbReference type="OMA" id="VMEYMNS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="464"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH94776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="58081" checksum="C1E57553A328E3D0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ53</accession>
    <name>A0A103XQ53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004514">
        <property type="protein sequence ID" value="KVH94868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ53"/>
    <dbReference type="STRING" id="59895.A0A103XQ53"/>
    <dbReference type="Gramene" id="KVH94868">
        <property type="protein sequence ID" value="KVH94868"/>
        <property type="gene ID" value="Ccrd_003064"/>
    </dbReference>
    <dbReference type="OMA" id="DLDCEGI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35117">
        <property type="entry name" value="MYOSIN-M HEAVY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35117:SF1">
        <property type="entry name" value="MYOSIN-M HEAVY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="506" mass="54420" checksum="C0EFF08125AFCAE3" modified="2016-04-13" version="1">MGKQTKSKRSENAVGKGKVTPVQVAFIVDRYLSDNNFVRTRSVFRSEASLLISKSPVNEAPKSLLSLGDMLDEYICLKEQKVILNQEKNRLEQEKFRVQTLLRGMQDAMNAYNVGGASASAAAPLPSPMVMPILSAGNTLASPAPSFPVYDTQVMMSTSRPSNSLSEVTNFSTPTTSQPNSKRRKSTKDVSGAPLALKRSRIQPSGNQLKPSGATKLVSQPTATSSNQETVLQITPAPSTTKSSLVQGSSVAKCLFNPSSHSPGPQTPSPSPIDKSISPVDNQTPPSSNKKTITPQQITSTNRTVITSETIQVSPMKQVSYYSIERNHCISSPLKSSAQRFTKRDHVKGRLDFDGSEMAAVSSEMLTSDENTGSPSEIEDNAFDFDLPNLDCLGVDFNLTDLLGDFDLDGDRLDYFCQPATGSSPESLSGSPDKLVDGCTGDHELLSGMSSTVTEIRSEQDMNMPGPNSRTSVTSITKCIKVFSPVKSRKTTGSDHESCGVEGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQK8</accession>
    <name>A0A103XQK8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004400">
        <property type="protein sequence ID" value="KVH95074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQK8"/>
    <dbReference type="Gramene" id="KVH95074">
        <property type="protein sequence ID" value="KVH95074"/>
        <property type="gene ID" value="Ccrd_002867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11342" checksum="84095326076D1294" modified="2016-04-13" version="1">MAKSGDVLVAYRPYSLSPAGNKIYCLVCEIPSRDEEKTESEPWRFHPKHRVKRKEDEEATNHHQLLILSFHNFHPANVKVFYLSLYTHSAIFIVNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQR5</accession>
    <name>A0A103XQR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004399">
        <property type="protein sequence ID" value="KVH95084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQR5"/>
    <dbReference type="STRING" id="59895.A0A103XQR5"/>
    <dbReference type="Gramene" id="KVH95084">
        <property type="protein sequence ID" value="KVH95084"/>
        <property type="gene ID" value="Ccrd_002805"/>
    </dbReference>
    <dbReference type="OMA" id="CDEHEAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="722" mass="71277" checksum="85D929BE39E977AA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRD2</accession>
    <name>A0A103XRD2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004386">
        <property type="protein sequence ID" value="KVH95496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XRD2"/>
    <dbReference type="Gramene" id="KVH95496">
        <property type="protein sequence ID" value="KVH95496"/>
        <property type="gene ID" value="Ccrd_002433"/>
    </dbReference>
    <dbReference type="OMA" id="INDLMGW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000007">
        <property type="entry name" value="Cytochrome P450 76C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951:SF7">
        <property type="entry name" value="FLAVONOID 3',5'-HYDROXYLASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951">
        <property type="entry name" value="OS08G0547900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="84650" checksum="54172512F84A144C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS70</accession>
    <name>A0A103XS70_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS70"/>
    <dbReference type="STRING" id="59895.A0A103XS70"/>
    <dbReference type="Gramene" id="KVH95884">
        <property type="protein sequence ID" value="KVH95884"/>
        <property type="gene ID" value="Ccrd_002042"/>
    </dbReference>
    <dbReference type="OMA" id="FMCASLE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF41">
        <property type="entry name" value="PROTEIN EPIDERMAL PATTERNING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027162005" description="Epidermal patterning factor-like protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="11784" checksum="7B29A3CC19190EF6" modified="2016-04-13" version="1">MKGSVFFSVLLLLPLFVSARHISWQHSRHGHHHHPSEVTTDGHGVAPGKHKVDTVAVAGSRLPDCSHACGSCSPCRLVMVSFICASIAEAETCPMAYKCMCKNKSYPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTA3</accession>
    <name>A0A103XTA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAPP II complex, Trs120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004288">
        <property type="protein sequence ID" value="KVH96484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTA3"/>
    <dbReference type="STRING" id="59895.A0A103XTA3"/>
    <dbReference type="Gramene" id="KVH96484">
        <property type="protein sequence ID" value="KVH96484"/>
        <property type="gene ID" value="Ccrd_001431"/>
    </dbReference>
    <dbReference type="OMA" id="ISHAEIQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="4">
        <location>
            <begin position="364"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="50288" checksum="1AE128EACEE9291F" modified="2016-04-13" version="1" fragment="single">EVKNNTLDCVNYPSALLRLLLSAFSAVLFPATATMEPDVSIDTSSIIRIAVLPIGTIHLHLFRKYAGMLGRHHKIELSTITSFYTEHQKSPFSQQPWESGSLKFKFIVGGSPPSPWEDFQSNRKIHGVIGICHCPSSPDLDSVVEQFAAACKGYSSSLVQRCFAFSPGDTQLADGNNKGNKLVLFPPADQRTQEIHLQTMMQDIAASLLMEFEKWVLQAESGGTILKTPLDSQASLSSEEVIKAKKRRLGRAQKTIGDYCLLAGSPVDANAHYSTALELARLTGDYFWYAGALEGGVCALLMDKAVQRDPIIEEEVKYRYNSVILHYRKSFIQDNAQRVSPLSFELEATLKLARFLCRRELAKEVVELLTSAADGAKSLIDASDRLILYIEIARLYGTLGYHRKAAFFSRQVAQLYLQQENSLAAISAMQVLALTTKAYRVQSRASIPKHAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU91</accession>
    <name>A0A103XU91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine peptidase, asparagine active site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003899">
        <property type="protein sequence ID" value="KVH97008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU91"/>
    <dbReference type="STRING" id="59895.A0A103XU91"/>
    <dbReference type="Gramene" id="KVH97008">
        <property type="protein sequence ID" value="KVH97008"/>
        <property type="gene ID" value="Ccrd_000898"/>
    </dbReference>
    <dbReference type="OMA" id="CGQNINH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000023">
        <property type="entry name" value="Senescence-specific cysteine protease SAG39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH97008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="315" mass="34640" checksum="50A0A6151B1B7296" modified="2016-04-13" version="1">MLSDLSMSEKHEMWMVRYGRVYKDDTEKEMRFKIFKDNMEFIESFNSGGNHPYKVGANAFADQTNEEFKAARNGYKFSTNKKLDQTTPFRYENVTVVPPSMDWRKKGAVTQVKDQGQCGSCWAFSTIAATEGITQLSTGKLISLSEQELVDCDRSGEDEGCEGGEMEDGFEFIIKNKGINTEAAYPYQAADGTCNTKEEAIYAAKISGYEKVPANSEKALLQAVANQPISVSIDASGYAFQLYSSGIFTGDCGTDLDHGVTAVGYGVTDDGMKYWLVKNSWGASWGDGGYIMMQRDVSAKQGLCGIAMDSSYPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUG3</accession>
    <name>A0A103XUG3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003853">
        <property type="protein sequence ID" value="KVH97142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUG3"/>
    <dbReference type="STRING" id="59895.A0A103XUG3"/>
    <dbReference type="Gramene" id="KVH97142">
        <property type="protein sequence ID" value="KVH97142"/>
        <property type="gene ID" value="Ccrd_000756"/>
    </dbReference>
    <dbReference type="OMA" id="MLVKIGM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34268:SF8">
        <property type="entry name" value="FAE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34268">
        <property type="entry name" value="OS01G0321850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="82" mass="8807" checksum="D4AA6D79D7CBA528" modified="2016-04-13" version="1">MVVEVQVISGDTLLKVALFILVQALVYLIITNSSNIFSTSAPTLRATSFKTARSASIRRIVAAFSDFPADNEVSPSTKTSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV27</accession>
    <name>A0A103XV27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV27"/>
    <dbReference type="Gramene" id="KVH97448">
        <property type="protein sequence ID" value="KVH97448"/>
        <property type="gene ID" value="Ccrd_000426"/>
    </dbReference>
    <dbReference type="OMA" id="FCKSHFA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF29">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="397" mass="42073" checksum="615E75017A2E615F" modified="2016-04-13" version="1">MVIVLPTATAKLLRLLSSISNAFSNPYFPTSLNLQSSVSMAGNESKTGTDVPLASTPNSKAQIKTVKVSNVSMAVNEKDIWEFFSFSGDIHYIEMKSESETTKHAFVTFKDSKGADTAALLTGATIADFSVSVTPVDNYKLPPEAPPLTARRREVVQKAEDVVSTMLAKGFVLGKDALRKAQSFDEKHQFTTSASTTYASLDRKIGLTKNLSMGRAVVNEKMKAVDERYQVSEATKSAIAVAEQKAASASNALMRNHYVSSGVLMVSNALSAFAKAAEDVGSKTKEKLDKAEEEKGVLNKENTNRVNDVDESSTKDSPVTVPATSSDNPAKSTDNPAISLDNPAKSTNNPATSLDNPAKSPDNPATSSGNPAKSPDNPATSSGNPAKSSDTSNPPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWQ0</accession>
    <name>A0A103XWQ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003803">
        <property type="protein sequence ID" value="KVH98298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWQ0"/>
    <dbReference type="STRING" id="59895.A0A103XWQ0"/>
    <dbReference type="Gramene" id="KVH98298">
        <property type="protein sequence ID" value="KVH98298"/>
        <property type="gene ID" value="Ccrd_023488"/>
    </dbReference>
    <dbReference type="OMA" id="SHIANCH"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20653">
        <property type="entry name" value="CYP81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF24">
        <property type="entry name" value="ISOFLAVONE 2'-HYDROXYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119181" evidence="8">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="503" mass="57251" checksum="7A2C5E830EC354D9" modified="2016-04-13" version="1">MEGLHLYLLLLILACSLFNKYVVPKIKNLPPTPLSALTVIGYLCFFKQPIHRTLAQIASRHGSILLLHFGCRRVLLISSSSAAEELFTKNDAAFANRPKLLPGKVFGHNYTNLAWAPHGALWCHLRRVSLLEILPFHRLPAQNESCTEEVRLLLGRLFHSEEKVIELKPMFLNLVLDVMMRMFAGKRYCTKKMAEGDVTQPISLLDYVTRSFRMTTGEPDVGYFMPILKLLGLRGLEQRCNDLQKKGDLLMDSIIHELKTRMLGSGEKEDKVIEFLLARQQDDPKLYPDEMIKGLVLVLTSAGTETSAGIMEWAFSLLLNHPEVLHKAQNEIENYVRNDRFLQPSDIEHLPYLSCIVKETLRMYPVAPLLVPHESSKECTISGYNVPKGTMLILNVWAIHHDPKIWDEPMKFKPERFEKVTGKRDAFKLMPFGYGRRSCPGKHMAVRVISLALGSLIHCFDWERVSEKKVDLTEETGLSLLKAQPLMAVCHPRSTMVNLLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXD5</accession>
    <name>A0A103XXD5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003767">
        <property type="protein sequence ID" value="KVH98678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXD5"/>
    <dbReference type="STRING" id="59895.A0A103XXD5"/>
    <dbReference type="Gramene" id="KVH98678">
        <property type="protein sequence ID" value="KVH98678"/>
        <property type="gene ID" value="Ccrd_023094"/>
    </dbReference>
    <dbReference type="OMA" id="KRKCCAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="161"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="859" mass="97072" checksum="606780C666A0D372" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYK1</accession>
    <name>A0A103XYK1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003635">
        <property type="protein sequence ID" value="KVH99166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYK1"/>
    <dbReference type="STRING" id="59895.A0A103XYK1"/>
    <dbReference type="Gramene" id="KVH99166">
        <property type="protein sequence ID" value="KVH99166"/>
        <property type="gene ID" value="Ccrd_022599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="49" mass="5447" checksum="83FF7B6A4F267C45" modified="2016-04-13" version="1">MGFIFTTLIFIVIGIIACFCTRICCNKGPSANLFHLTLVITATICCWMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZB0</accession>
    <name>A0A103XZB0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_022117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003425">
        <property type="protein sequence ID" value="KVH99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZB0"/>
    <dbReference type="STRING" id="59895.A0A103XZB0"/>
    <dbReference type="Gramene" id="KVH99653">
        <property type="protein sequence ID" value="KVH99653"/>
        <property type="gene ID" value="Ccrd_022117"/>
    </dbReference>
    <dbReference type="OMA" id="ACWKEKL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01374">
        <property type="entry name" value="KISc_CENP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000026">
        <property type="entry name" value="Centromere-associated protein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="621"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="770"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="899" mass="101317" checksum="728DD0CD646F8466" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZG2</accession>
    <name>A0A103XZG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wall-associated receptor kinase galacturonan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003417">
        <property type="protein sequence ID" value="KVH99718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XZG2"/>
    <dbReference type="Gramene" id="KVH99718">
        <property type="protein sequence ID" value="KVH99718"/>
        <property type="gene ID" value="Ccrd_022050"/>
    </dbReference>
    <dbReference type="OMA" id="CDTRANI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="3">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="421" mass="46589" checksum="6A65BF2401E87F74" modified="2016-04-13" version="1" fragment="single">PAFVLLFNHLQIKAFVLLFNHLQIXLRPTLQPSSNQGLRPTLQPSSNLKHRFQVKSIQMPRFTMTILHFTILVLILSTTFAGSESAQSLSLPACPDKCGNITIPYPFGTKKGCYLTKSYLVNCTTLRLSNTRFKLLHISLNGSMRGFLPMGYRCYNKTRGLISASEPRIALSRFPISSTHNLLTAVGCDTRANIKAYEGEDYITGCLSMTGCDGLTNGSCLGMGCSQVPVPYDLTSFRIHAQSNTGKVGKWSYNNCTYAFLVEKDRYTFVETDLDNMRNRSFPVVLEWSVGNTSCKIAQMNKTTHLCKENSVCYDDSIISFNQGPKHDCVHACGNTNGSYNCSCPLGMGGDGRKDGTGCSYLEAAKSLKSSVYLGQYQHGNRGFSCVNTYLILGSQTKANHEEQGEVLQEKRRIDLAETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZR1</accession>
    <name>A0A103XZR1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003409">
        <property type="protein sequence ID" value="KVH99878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZR1"/>
    <dbReference type="STRING" id="59895.A0A103XZR1"/>
    <dbReference type="Gramene" id="KVH99878">
        <property type="protein sequence ID" value="KVH99878"/>
        <property type="gene ID" value="Ccrd_021880"/>
    </dbReference>
    <dbReference type="OMA" id="HIHFVEE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF301">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING DOMAIN, PGG DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="502"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="675" mass="76001" checksum="ABDAA79DDC3C4F1E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y018</accession>
    <name>A0A103Y018_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVH99975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y018"/>
    <dbReference type="STRING" id="59895.A0A103Y018"/>
    <dbReference type="Gramene" id="KVH99975">
        <property type="protein sequence ID" value="KVH99975"/>
        <property type="gene ID" value="Ccrd_021765"/>
    </dbReference>
    <dbReference type="OMA" id="SIYIDIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238">
        <property type="entry name" value="MEMBRANE BOUND PREDICTED REDOX MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="THYLAKOID MEMBRANE PROTEIN TERC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="266" mass="30267" checksum="9D4C07FE0AEFE626" modified="2016-04-13" version="1">MKLASIIQNGMHPSIKFDVGLLNFASSSTSTQFPKWVHLQFTHSPNLSFDSAVCRNRWPRKLSIVRSKGVEQEEFSSSERETSSSNSYIDNAESKSHLIIDNDSEEKTKDLITYKTSARTVALCVLSAVAFGVGLGLKDGIGKASEFFAGYLLEQSLSVDNLFVFVLVFKYFKVPLAYQLFSAGDDDEEDLSDNFIVKTCQKIIPLHMMAIDFLQLKMELGKFKVSIYIDIRRHGRFGVPTTLHWHRSRLHWMQNDPRFLRVPCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1G0</accession>
    <name>A0A103Y1G0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003267">
        <property type="protein sequence ID" value="KVI00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1G0"/>
    <dbReference type="STRING" id="59895.A0A103Y1G0"/>
    <dbReference type="Gramene" id="KVI00774">
        <property type="protein sequence ID" value="KVI00774"/>
        <property type="gene ID" value="Ccrd_020973"/>
    </dbReference>
    <dbReference type="OMA" id="QHANGRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080124">
        <property type="term" value="F:pheophytinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000136">
        <property type="entry name" value="Pheophytinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044211">
        <property type="entry name" value="PPH_chloroplastic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47280">
        <property type="entry name" value="PHEOPHYTINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47280:SF1">
        <property type="entry name" value="PHEOPHYTINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="520" mass="58817" checksum="8B4E78125644AAF9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y257</accession>
    <name>A0A103Y257_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase, N2/N3-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003126">
        <property type="protein sequence ID" value="KVI01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y257"/>
    <dbReference type="STRING" id="59895.A0A103Y257"/>
    <dbReference type="Gramene" id="KVI01145">
        <property type="protein sequence ID" value="KVI01145"/>
        <property type="gene ID" value="Ccrd_020560"/>
    </dbReference>
    <dbReference type="OMA" id="NTSVEMF"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017126">
        <property type="term" value="P:nucleologenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000016">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044673">
        <property type="entry name" value="DCL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33415">
        <property type="entry name" value="PROTEIN EMBRYO DEFECTIVE 514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33415:SF12">
        <property type="entry name" value="PROTEIN EMBRYO DEFECTIVE 514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11523">
        <property type="entry name" value="DUF3223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24744" checksum="D69632316CBA8386" modified="2016-04-13" version="1">MAEEAGAPVTAVVETVKDDSSAAPQEMDLETVEPANGGKREREEEVTTESSENGNNAKKPKVDEEEKSVEEEKLEKEAAKTGPVSVGYKSFETSVQIFDYFFKFLHFWPPNLNVNKYEHAMLLDLLKKGHLEAEKKIGAGIHAFQVRYHPQWKSRCFFLVREDESADDFSFRKCVDHILPLPENMTVKSDVNKVLGGGSGGRGGRGGGCGNWRGRGRGGKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3J4</accession>
    <name>A0A103Y3J4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002673">
        <property type="protein sequence ID" value="KVI01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3J4"/>
    <dbReference type="STRING" id="59895.A0A103Y3J4"/>
    <dbReference type="Gramene" id="KVI01889">
        <property type="protein sequence ID" value="KVI01889"/>
        <property type="gene ID" value="Ccrd_019829"/>
    </dbReference>
    <dbReference type="OMA" id="GRQAHQK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="52107" checksum="3F329D959CCF0B6F" modified="2016-04-13" version="1">MAVLSHLRRALLRSPPVITGCGGARTLTPSYHHVQAKNNSTKVEDEKNENKKGKWLSLPPFNMTVNGASLGRDIVGRRKSIDEGEASTTTALKWVMRCCPQLPRSLVQKLFRLRQVRRGTSEGSNSDQDVQAPGCRIKRVSAKDSMKCGDTIYLPITVQALPTEKVECLCSEEELKFLHDLVLYKDSAILVINKPPGMPVQGGIGIKRSLDELAGAYLRHDFSEPPRLVHRLDRDSSGILVLGRTQLSATVLHSVFREKTIGASNIDLKSEKRFLQRKYWALVLGSPRRPQGLISVPLGKVVMDDGRSERITVVENVSTMSSQHAITEYRVLESSNHGGVDEDELIWWIRVHCAEVLGTPIVGDYKYGWQAHKKWNQLFSSNLEEKVEVCKRKSLPFGLDLESGSISDKQPNLHLHCKKMVLPDVSSALERARISSSDYDFGDIKSLKFAAPLPPHMQRSWDILCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4E1</accession>
    <name>A0A103Y4E1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal-associated domain, HMA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002659">
        <property type="protein sequence ID" value="KVI02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4E1"/>
    <dbReference type="STRING" id="59895.A0A103Y4E1"/>
    <dbReference type="Gramene" id="KVI02316">
        <property type="protein sequence ID" value="KVI02316"/>
        <property type="gene ID" value="Ccrd_019398"/>
    </dbReference>
    <dbReference type="OMA" id="MRCEKCR"/>
    <dbReference type="OrthoDB" id="692882at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042885">
        <property type="entry name" value="HIPP47/16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46932">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46932:SF12">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8034" checksum="6E8316D753B3097F" modified="2016-04-13" version="1">MTQRIVIKMQPKCGRCRTRAMMVAAQASGVYSVELQGDNKNQMVVTGDGINAAALTSSVRKKVKHASLETVQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4E7</accession>
    <name>A0A103Y4E7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002659">
        <property type="protein sequence ID" value="KVI02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4E7"/>
    <dbReference type="Gramene" id="KVI02315">
        <property type="protein sequence ID" value="KVI02315"/>
        <property type="gene ID" value="Ccrd_019423"/>
    </dbReference>
    <dbReference type="OMA" id="TEWASYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF108">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="5">
        <location>
            <begin position="168"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="5">
        <location>
            <begin position="611"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="802" mass="90840" checksum="B58CA728B81875C5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4X1</accession>
    <name>A0A103Y4X1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002649">
        <property type="protein sequence ID" value="KVI02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4X1"/>
    <dbReference type="STRING" id="59895.A0A103Y4X1"/>
    <dbReference type="Gramene" id="KVI02606">
        <property type="protein sequence ID" value="KVI02606"/>
        <property type="gene ID" value="Ccrd_019097"/>
    </dbReference>
    <dbReference type="OMA" id="FKECGIV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF643">
        <property type="entry name" value="AMINO ACID TRANSPORTER AVT6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="95"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="278"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="481" mass="53238" checksum="C3A2C7DE1FE89852" modified="2016-04-13" version="1">MFFPLLIASIQIDWFLEFQKLSIWENANFNRNCFEFSLRRLCSKKSKSDYRMTIEIRNPSNENRSRNRKQVIVDDKVPLLPTKKEEDGGLEEFDGASFTGAVFNLSTTIVGAGIMALPATMKVLGLIPGIALIIIMAFLTESSIDLLIRFSRARKSVSYGGLMEDEFGKVGRILLQVCVLVNNIGVLVVYMIIIGDVLSGINSNGIHHAGVLQEWFGEHWWNGRFFILLVTTLFVFAPLAGLKRIDSLRYTSALSMALAVVFLVIIAGITIFKLMIGSIMMPRLFPQVVDFASIKAVVRASLILCSTVYIMTSLFGFLLFGDGTLDDVLTNFDTDLGVPYSLLLNDIVRVSYAAHLILVFPIVFFPLRLNMDGLLFPNKRPLILDNMRFASVTIGLMVLVFLGANFIPSIWVAFEFTGATAAVCIGFIFPSAITLRDCYGIASKKDKILCVFMIALAAFSNLMAVYSNASALLSNNGSPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5A5</accession>
    <name>A0A103Y5A5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002633">
        <property type="protein sequence ID" value="KVI02772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5A5"/>
    <dbReference type="Gramene" id="KVI02772">
        <property type="protein sequence ID" value="KVI02772"/>
        <property type="gene ID" value="Ccrd_018938"/>
    </dbReference>
    <dbReference type="OMA" id="PEQDHIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000005">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF859">
        <property type="entry name" value="OS03G0690500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="546"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="698" mass="77752" checksum="4FB1E0CC312EC144" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y604</accession>
    <name>A0A103Y604_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_018546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002452">
        <property type="protein sequence ID" value="KVI03159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y604"/>
    <dbReference type="STRING" id="59895.A0A103Y604"/>
    <dbReference type="Gramene" id="KVI03159">
        <property type="protein sequence ID" value="KVI03159"/>
        <property type="gene ID" value="Ccrd_018546"/>
    </dbReference>
    <dbReference type="OMA" id="PEMMYEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000159">
        <property type="entry name" value="Homeobox-leucine zipper protein HAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF547">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI03159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="309" mass="34850" checksum="AB99A6344FD15037" modified="2016-04-13" version="1">MEKKDGGNGHSLNPSSLSSFKPPPFAAMEVVSNIGSSESMAGLMPMCSTIEEGGNSPVGYTREFQSMLMEGLDEDGGGEESAGGQISEKKRRLSVDQVKALEKNFEMENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLERDYGVLKANFDSLKNNYESLKHDNESLLKQIRELKSKLYGEDEETHVPVKEETGDKPKSPEMMYENMTTYFKDGSSDSDSSAILNEDNNSSNMAAAIVMNCQQLPESKAIMGDAQKAYQPQFVKIEEHNFFSGDESCNFFSDDQAPTLQWYCQDQWNLTEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y659</accession>
    <name>A0A103Y659_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002396">
        <property type="protein sequence ID" value="KVI03247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y659"/>
    <dbReference type="Gramene" id="KVI03247">
        <property type="protein sequence ID" value="KVI03247"/>
        <property type="gene ID" value="Ccrd_018456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="86" mass="9463" checksum="93F8936178E5DF1D" modified="2016-04-13" version="1">MAYRRKQGGLSRSSTFKEEIRHQDHDIITTSASSSTAPSSPLARRTNANSPSQSQAARLDSFLSSGAFHSSLKDRSKKIKEEKPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6S7</accession>
    <name>A0A103Y6S7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002342">
        <property type="protein sequence ID" value="KVI03559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6S7"/>
    <dbReference type="STRING" id="59895.A0A103Y6S7"/>
    <dbReference type="Gramene" id="KVI03559">
        <property type="protein sequence ID" value="KVI03559"/>
        <property type="gene ID" value="Ccrd_018128"/>
    </dbReference>
    <dbReference type="OMA" id="CETLIDD"/>
    <dbReference type="OrthoDB" id="696504at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34120:SF2">
        <property type="entry name" value="OS01G0860900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="31625" checksum="E456E8B19CC85BA3" modified="2016-04-13" version="1">MPQVDTETIVPVGGAGDRKIGSETLEDGEYKAEVDPDIPDSSQFVPPESFWLSKDSEFDWFDRNAFLERKESTKASNSKNLNPNVNPTYSHSNSQRFSVNLKSKAAILGLPKTQRNTHVESKYRQCKPANIRLFPKRSSSGGRAPGAVPVTEPSSPKVSCIGRVRSKRCRSRRRSSVAATRSEKPVAVIQPEKTSKGQKKGIISRITSLFRSEGSRRRKNNKSSVKLNEHLEKSASRRSSVTVKPVNSEPATPSAPPALGGMNRFASGRRSESWTDNIDIAGRRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7F4</accession>
    <name>A0A103Y7F4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002321">
        <property type="protein sequence ID" value="KVI03909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7F4"/>
    <dbReference type="STRING" id="59895.A0A103Y7F4"/>
    <dbReference type="Gramene" id="KVI03909">
        <property type="protein sequence ID" value="KVI03909"/>
        <property type="gene ID" value="Ccrd_017773"/>
    </dbReference>
    <dbReference type="OMA" id="FTGMHKX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12361">
        <property type="entry name" value="RRM1_2_CELF1-6_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000302">
        <property type="entry name" value="RNA-binding protein BRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000216">
        <property type="entry name" value="RNA-binding protein BRN1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="40222" checksum="0A98A653397EF402" modified="2016-04-13" version="1">MAEGQKPRKHSDDSVKLFVGQVPKHMTESQLSAMFEEFALVDEVNIIKDKATRASRGCCFVICPSREEADKAVDACHNKRTLPGASCPLQVKYADGELERLEHKLFIGMLPKNVSEGEVSELFSQFGTLKDLQILRGSQQTSKGCAFVKYETKEQAVAAIEGLNGKHKMEGSPVPLVVKWADTEKERLARKAQKAQSLASSLANADPTQHPSLFGALPMGYISPYNGYGYQAAGSYGLMQYRIPPGQNQPSFPNVIPHANQGGTPRNYAVPPAGYTYPAVPGAQYPLAYTGGMMSNQPLSGPPSPVPPPIANNLAATSSSISASPGDQVEGPPGANLFIYHIPQEFGDEELANAFKGFGRVLSAKVYPLSPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y876</accession>
    <name>A0A103Y876_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002238">
        <property type="protein sequence ID" value="KVI04312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y876"/>
    <dbReference type="STRING" id="59895.A0A103Y876"/>
    <dbReference type="Gramene" id="KVI04312">
        <property type="protein sequence ID" value="KVI04312"/>
        <property type="gene ID" value="Ccrd_017382"/>
    </dbReference>
    <dbReference type="OMA" id="TCDMAHA"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15596" checksum="E0F46198A26A83F7" modified="2016-04-13" version="1">MQQAIPYKAWTTLPLKHTTGDRKPMSQFDGSATGAVRDAVSENAVIVLARRGCCMSHVVKRLLNGHGVNPSVFEFEEDEENDVVKELEMIESENDGNDKRRVQFPAVFIGGRMFGGLDRVMATHITGELIPVLKQAGALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8L1</accession>
    <name>A0A103Y8L1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">Ccrd_017162</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002016">
        <property type="protein sequence ID" value="KVI04521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8L1"/>
    <dbReference type="Gramene" id="KVI04521">
        <property type="protein sequence ID" value="KVI04521"/>
        <property type="gene ID" value="Ccrd_017162"/>
    </dbReference>
    <dbReference type="OMA" id="NQNGAVW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905393">
        <property type="term" value="P:plant organ formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000632">
        <property type="entry name" value="leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000292">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF171">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 25" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119487" description="non-specific serine/threonine protein kinase" evidence="25">
        <location>
            <begin position="25"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="704"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="969"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KVI04521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111355" checksum="A3D802B0B8C304A6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8Q0</accession>
    <name>A0A103Y8Q0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001987">
        <property type="protein sequence ID" value="KVI04568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8Q0"/>
    <dbReference type="Gramene" id="KVI04568">
        <property type="protein sequence ID" value="KVI04568"/>
        <property type="gene ID" value="Ccrd_017114"/>
    </dbReference>
    <dbReference type="OMA" id="EEKCRYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF35">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="345" mass="37894" checksum="E6D9581435D5A56A" modified="2016-04-13" version="1">MMSNHDEQFEATHTEGSKMGIDLVGKTVKNKQIIFKGYIDGSPMENDMELKLGDGLKLEVPKGSNAIVVKNLYLSCDPYMRGRMLDFRGSYIPPFTPGSAIEGFGVSKVVDSDDPNFKRGDLVSGITNWEEYSLIHKTDQLRKIEQDDGIPLSYHVGLLGVYTPLAYSVCDPKKGDYVYVSAASGAVGQLVGQLAKLHGCYVVGSAGTSKKVELLKDKLGYFPEGIDIYFDNVGGAMLDAALANMRIHGRVAVCGMVSQTNRTDTQTFLNMFSVISKRVTIKGFLQSDFVHLYARFLEDITGWYKQRKIVYIEDMNNGLESAPAAFVGLFSGKNVGKQVICVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9A3</accession>
    <name>A0A103Y9A3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001902">
        <property type="protein sequence ID" value="KVI04887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9A3"/>
    <dbReference type="STRING" id="59895.A0A103Y9A3"/>
    <dbReference type="Gramene" id="KVI04887">
        <property type="protein sequence ID" value="KVI04887"/>
        <property type="gene ID" value="Ccrd_016799"/>
    </dbReference>
    <dbReference type="OMA" id="KWEVSIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF166">
        <property type="entry name" value="GPCR KINASE, CALCIUM_CALMODULIN-DEPENDENT_CALCIUM-DEPENDENT PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="88" mass="9824" checksum="303C6C1C12E202C3" modified="2016-04-13" version="1">MAANSPTTTTRKEGQFLLLGRYEIGKLLGHGTFSKVYLACNAKTNESVALEVIDKGQILKGCLISHIKREISILRRVRHLNIVQLFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9N7</accession>
    <name>A0A103Y9N7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9N7"/>
    <dbReference type="Gramene" id="KVI05064">
        <property type="protein sequence ID" value="KVI05064"/>
        <property type="gene ID" value="Ccrd_016621"/>
    </dbReference>
    <dbReference type="OMA" id="HAGDWLT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="37037" checksum="9AA80FA8A886ABAD" modified="2016-04-13" version="1">MSNSSSETCIQLPEHMYQKGVKHLCENGVTQVPKKYILSEPERPHNLVVGSCIDLPVIDFAQLQGNDRPAVLRSLAKACQEYGFFQLTNHGITNDVVGKMIDVSKRFFELPFEERQRYMSSNLYAPVRYGTSFNQNNDGVFCWRDFLKLSCYPMQDFAILASLGVMEEDKAILDDANQLTMVNCYPSCPQPQLTLGLPPHSDYGLLTLLLQDQVEGLQIQHKGRWLTVKPIPNSLVVNIGDQFEIFSNGRYKSVVHRVAVNSMSSRLSVATLFSLPVNHNVRPSPELIDESNPRRYRDTNYADFLEFLSSSDFKCKKFLELRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9Q1</accession>
    <name>A0A103Y9Q1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001889">
        <property type="protein sequence ID" value="KVI05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9Q1"/>
    <dbReference type="Gramene" id="KVI05107">
        <property type="protein sequence ID" value="KVI05107"/>
        <property type="gene ID" value="Ccrd_016560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16711" checksum="BC3EBD3659C7AEF8" modified="2016-04-13" version="1">MYIYFASCISLGLQDEYNMKIREEAPAATVAARQPIDRKTLAAPDEPPGDMDPIDVETHRREEPALGSCLKEYYIDGGGGGGGVGRKQEWIGITKWKRRREWKLFSSYGVEGCGGYARVGWPVVESSRKWKGADVLVFNNIHWWNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAR7</accession>
    <name>A0A103YAR7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ELK-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TALE/KNOX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAR7"/>
    <dbReference type="STRING" id="59895.A0A103YAR7"/>
    <dbReference type="Gramene" id="KVI05662">
        <property type="protein sequence ID" value="KVI05662"/>
        <property type="gene ID" value="Ccrd_016007"/>
    </dbReference>
    <dbReference type="OMA" id="MEVTIHC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03789">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51213">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19291" checksum="3C7E6B5409790584" modified="2016-04-13" version="1" fragment="single">MEMGSRMKGVRSFGFLKRRQSQWPDMQLLIRSRGGGGGSVDEVTISSEEEFSGGETDNAQMSQELKDTLLRKFGGRIGSLKQEFTKKKKKGKLPKEARQTLLEWWNSHYKWPYPTEGDKISLAETTGLDPKQINNWFINQRKRHWKPPENMQLAVMGGGLPGQHFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAX1</accession>
    <name>A0A103YAX1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAX1"/>
    <dbReference type="STRING" id="59895.A0A103YAX1"/>
    <dbReference type="Gramene" id="KVI05725">
        <property type="protein sequence ID" value="KVI05725"/>
        <property type="gene ID" value="Ccrd_015942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF6">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE_RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="29340" checksum="933DD2F2BF3F56AA" modified="2016-04-13" version="1">MTNACFISLRCFHHPKRKKLRVDLFRPLSTSVSPLHRAPLTSLVHHSQPLTLTSQLSPSDAPSQRSEEWFALRRDKLTTSTFSTALGFWKGRRRYELWHEKGQMEVMNREWVDLYCWTPNGSTIFRVCRDQEYWALIHGILREFWWENVVPAREALSMGSEEEAKKYEPTSTHDQTESVIRKSKELASKKMEVFNSKGTSWAEQWDPVQDPPVNEKKNEDKKKKEETRGKGAMKSILSLAWMKNLGKKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD87</accession>
    <name>A0A103YD87_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic</fullName>
            <shortName evidence="6">RA</shortName>
            <shortName evidence="6">RuBisCO activase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4.1.1.39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Plastid</location>
            <location evidence="1 6">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RuBisCO activase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001537">
        <property type="protein sequence ID" value="KVI06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD87"/>
    <dbReference type="STRING" id="59895.A0A103YD87"/>
    <dbReference type="Gramene" id="KVI06957">
        <property type="protein sequence ID" value="KVI06957"/>
        <property type="gene ID" value="Ccrd_014684"/>
    </dbReference>
    <dbReference type="OMA" id="ANADAIX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046863">
        <property type="term" value="F:ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1070:FF:000001">
        <property type="entry name" value="Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044960">
        <property type="entry name" value="RCA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048571">
        <property type="entry name" value="RuBisCO_activase_AAA_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429:SF40">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE_OXYGENASE ACTIVASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21228">
        <property type="entry name" value="RuBisCO_activase_AAA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Ribulose bisphosphate carboxylase/oxygenase activase AAA helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="422" mass="46453" checksum="44BAA1E61E054808" modified="2016-04-13" version="1">MATAISTIGAVNRVPLSFNGSTGSAAVPSSTFLGSSLKKIVNSRVSSNNNNKSFSFKVLAAEKEIEESQQTEKDRWKGLAYDMSDDQQDITRGKGMVDSLFQAPQDVGTHFAVMSSYEYISTGLRTYNLDNMKDGFYIAPAFMDKLVVHITKNFLTLPNIKVPLILGVWGGKGQGKSFQCELVFAKMGITQRYREAADIIKKGKMCCLFINDLDAGAGRMGGTTQYTVNNQMVNATLMNIADNPTNVQLPGMYNKEENPRVPIIVTGNDFSTLYAPLIRDGRMEKFYWAPTREDRIGVCIGIFRTDGVTPEQVSKLVDTFPGQSIDFFGALRARVYDDEVRTWIGGVGVEGIGKKLVNSKEGPPTFEQPEITIDKLLEYGTMLVKEQENQVQVPVPEGCTDPGAENFDPTARSDDGSCTYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE07</accession>
    <name>A0A103YE07_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE07"/>
    <dbReference type="Gramene" id="KVI07364">
        <property type="protein sequence ID" value="KVI07364"/>
        <property type="gene ID" value="Ccrd_014293"/>
    </dbReference>
    <dbReference type="OMA" id="GYIWMPN"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48166">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48166:SF4">
        <property type="entry name" value="OS03G0142900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62113" checksum="ADAD000768C2AF0D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE47</accession>
    <name>A0A103YE47_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01001507">
        <property type="protein sequence ID" value="KVI07420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE47"/>
    <dbReference type="STRING" id="59895.A0A103YE47"/>
    <dbReference type="Gramene" id="KVI07420">
        <property type="protein sequence ID" value="KVI07420"/>
        <property type="gene ID" value="Ccrd_014250"/>
    </dbReference>
    <dbReference type="OMA" id="DECICKR"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000212">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="37568" checksum="035C8B95ADC16BB5" modified="2016-04-13" version="1">MDQYVLDNMIRRLLEVKGRPGKQVQLTEPEIKQLCVVSREIFLRQPNLLELEAPIKICGDIHGQYSDLLRLFEYGGLPPRANYLFLGDYVDRGKQSLETICLLLAYKIKYPNNFFLLRGNHECASINRIYGFYDECKRRFNVKLWKIFSDCFNCLPVAALIDEKILCMHGGLSPDLNNLDQIRNLRRPTDVPDGGLLCDLLWSDPCKDVKGWGMNDRGVSYTFGANIVTDFLQKHDLDLVCRAHQVVEDGYEFFANRQLVTVFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKPKFNPGINFFGSTTTAKPGNTPPGVKPFLGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEC2</accession>
    <name>A0A103YEC2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001504">
        <property type="protein sequence ID" value="KVI07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEC2"/>
    <dbReference type="STRING" id="59895.A0A103YEC2"/>
    <dbReference type="Gramene" id="KVI07506">
        <property type="protein sequence ID" value="KVI07506"/>
        <property type="gene ID" value="Ccrd_014134"/>
    </dbReference>
    <dbReference type="OMA" id="CETDIKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000447">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="42741" checksum="02220A066A87EC9C" modified="2016-04-13" version="1">MLVSSRATAVSSAAPHRFLTHSVNNFNCISSSLSLPTSFGSSSLINDDRRQKKINTTVGWSNRMDKKKISVVTCATASVAAQPLENADALIDSVETFIFDCDGVIWKGDSLIEGVPETLELLRSKGKRLVFVTNNSTKSRKQYGKKFESLGLSINEEEIFASSFAAAAYLQSIDFPKDKKIDPLLAYLLTAPFYEPVGNMSHVLITCMPRVFLREQERIYVIGEEGILIELELAGFSYLGGPEDGGKKIELKPGYMMEHDKDVGAVVVGFDRYFNYYKVQYGTLCVRENPGCLFLATNRDAVTHLTDAQEWAVVVGKPSTFMMDYLANKFSITKSQICMVGDRLDTDILFGQNGGCKTLLVLSGMFSLHLLATFFLNFLVSVFTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEI6</accession>
    <name>A0A103YEI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEI6"/>
    <dbReference type="Gramene" id="KVI07629">
        <property type="protein sequence ID" value="KVI07629"/>
        <property type="gene ID" value="Ccrd_014028"/>
    </dbReference>
    <dbReference type="OMA" id="ENIPDMC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="563" mass="63506" checksum="D0E8EAF33EF3B652" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGD4</accession>
    <name>A0A103YGD4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001103">
        <property type="protein sequence ID" value="KVI08609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGD4"/>
    <dbReference type="STRING" id="59895.A0A103YGD4"/>
    <dbReference type="Gramene" id="KVI08609">
        <property type="protein sequence ID" value="KVI08609"/>
        <property type="gene ID" value="Ccrd_013019"/>
    </dbReference>
    <dbReference type="OMA" id="LSTWINF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34121:SF1">
        <property type="entry name" value="FILAMIN-A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34121">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="765" mass="86444" checksum="B895A4EEF91D1313" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH69</accession>
    <name>A0A103YH69_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001074">
        <property type="protein sequence ID" value="KVI09026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH69"/>
    <dbReference type="STRING" id="59895.A0A103YH69"/>
    <dbReference type="Gramene" id="KVI09026">
        <property type="protein sequence ID" value="KVI09026"/>
        <property type="gene ID" value="Ccrd_012604"/>
    </dbReference>
    <dbReference type="OMA" id="PNYAIPF"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF1">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119713" evidence="4">
        <location>
            <begin position="22"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="375" mass="40916" checksum="CA8DB6250A597213" modified="2016-04-13" version="1">MDCHHPIAALILFIVFTVAAADGNHNDGGSILGASYIFGDSLVDAGNNNFLPTLSRANIKPNGIDFKPSGGKPTGRYTNGRTIGDIVGEELGQRYYAVPFLDPNSTGEAILHGVNYASGGGGIMNATGRIFVNRLSMDIQIDYFNITRKQIDKLLGASKAKEHIMKKSIFSVSIGSNDFLNNYLLPVLSIGARVSQSPDGFVDDLISHLRSQLTRLYQLDARKFIIGNVGPIGCIPYQKTINQLNEDECVALPNQLALRYNSKLKDLIAQMNDNLPGATFVHANVYDLVMELITNYAKYGFKTASKACCGNGGQYAGIIPCGPTSTLCTDRDKHVFWDPYHPSEAANVLIAKQLLDGDPKYISPMNLRQLRDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHK8</accession>
    <name>A0A103YHK8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHK8"/>
    <dbReference type="STRING" id="59895.A0A103YHK8"/>
    <dbReference type="Gramene" id="KVI09234">
        <property type="protein sequence ID" value="KVI09234"/>
        <property type="gene ID" value="Ccrd_012385"/>
    </dbReference>
    <dbReference type="OMA" id="AVHIHIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021775">
        <property type="entry name" value="DUF3339"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128">
        <property type="entry name" value="OS05G0103400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11820">
        <property type="entry name" value="DUF3339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7535" checksum="7927A1A419E8AC84" modified="2016-04-13" version="1">MADWGPILIGVVLFVLLQPGLLFQLPGNSKQLEFGSMKTNGKAIAVHTLIFFAIYAILILAVHIHIYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJI4</accession>
    <name>A0A103YJI4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001024">
        <property type="protein sequence ID" value="KVI10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YJI4"/>
    <dbReference type="Gramene" id="KVI10281">
        <property type="protein sequence ID" value="KVI10281"/>
        <property type="gene ID" value="Ccrd_011319"/>
    </dbReference>
    <dbReference type="OMA" id="AWFTEAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF3">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="603"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1304" mass="138473" checksum="50C20541C4EB146E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKK0</accession>
    <name>A0A103YKK0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000998">
        <property type="protein sequence ID" value="KVI10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKK0"/>
    <dbReference type="STRING" id="59895.A0A103YKK0"/>
    <dbReference type="Gramene" id="KVI10799">
        <property type="protein sequence ID" value="KVI10799"/>
        <property type="gene ID" value="Ccrd_010806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="19131" checksum="FCD370FB1BEC3869" modified="2016-04-13" version="1" fragment="single">MLHLIHRPSVDSISIRLQSSSHTVNVFFNSLSIINIPDPRLQLLSNLSKSQRSVPTSIEFVGIVGLVKGASQGEGLGNKFLSHIREVDSILQVVRCFEDNDIVHVNGQVDPKSDIDAINLELAFSYLDQLSSTRLWRYESGEKSAANEVVLWIKNQQLKGCFVAKDQQLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKL6</accession>
    <name>A0A103YKL6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_010705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type IV zinc-finger family. Class C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000986">
        <property type="protein sequence ID" value="KVI10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKL6"/>
    <dbReference type="STRING" id="59895.A0A103YKL6"/>
    <dbReference type="Gramene" id="KVI10879">
        <property type="protein sequence ID" value="KVI10879"/>
        <property type="gene ID" value="Ccrd_010705"/>
    </dbReference>
    <dbReference type="OMA" id="MYGRETM"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045280">
        <property type="entry name" value="TIFY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125:SF24">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00979">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tify" evidence="17">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="16">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="248"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="37407" checksum="7EEFDB9CF7DE5067" modified="2016-04-13" version="1">MMSEANISNQRHHQAPTYEPANLQHHQQQQGIAINNNDDEGNQHHMVEDVVVEEDDDVAGGEEESIDNPSQIRYDHHNPHHQHHDLRNGVALEGGMEEMSAPPHALYVQDSEIQPLAVGGGGADQLTLSFQGEVYVFDAVSPEKVQAVLLLLGGYEVPTGVPSLGMPPQNQRDLAEFPTRSSQPQRAASLSRFREKRKERCFDKKIRYSVRKEVALRMQRKKGQFTSSKAISDEAGSASSDWNGGPSQDEETTCRHCGISSKSTPMMRRGPAGPRTLCNACGLKWANKGVLRDLTKVSASGTQDPAGKPIEQSDGEANNLDAINANAVMVVSNGDTSAVTAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLD0</accession>
    <name>A0A103YLD0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_010306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000469">
        <property type="protein sequence ID" value="KVI11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLD0"/>
    <dbReference type="Gramene" id="KVI11285">
        <property type="protein sequence ID" value="KVI11285"/>
        <property type="gene ID" value="Ccrd_010306"/>
    </dbReference>
    <dbReference type="OMA" id="WFERELM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF27">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="46840" checksum="F67562E5CAEAE205" modified="2016-04-13" version="1">METSGLSSDAHRGSLASTSTSDHHYHHSRRNNGNNHFSASNFFRSPVSAFLEYMGILQTQRTSHSESSDSLINDENTQNDSPGSGDEEVSIRIIGSGEQGQDRDGGGASSSTIGQIREGTAIQNESLLQSISRTASAATMDTQGDSRSDGVSASIRGAMDSVSGNVDSEAAEGVGVNNSRDSSYQRYDIQQAARWAEQVLPFTLLLLVVFIRQHLQGFFVTIWITAFMFKSNDILRRQTALKGERKILVLASISLLFTLHVAGVYWWYRKDDLLYPLVMLPPKSIPPFWHAIFLVIVNDTLARQAAMVLKCFLLMYYKNSRGRNRRKQGQMLTLVEYLLLLYRVLLPAPVWYRFFLNKEYGSLFSSLMTGLYLTFKLTCVVEKVNAPGELCAICQEKMHSPVVLRCKHVFCEECVSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLY6</accession>
    <name>A0A103YLY6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pathogenic type III effector avirulence factor Avr cleavage site-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000089">
        <property type="protein sequence ID" value="KVI11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLY6"/>
    <dbReference type="STRING" id="59895.A0A103YLY6"/>
    <dbReference type="Gramene" id="KVI11532">
        <property type="protein sequence ID" value="KVI11532"/>
        <property type="gene ID" value="Ccrd_010057"/>
    </dbReference>
    <dbReference type="OMA" id="TSPIVMA"/>
    <dbReference type="OrthoDB" id="755325at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33699">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33699:SF2">
        <property type="entry name" value="PATHOGENIC TYPE III EFFECTOR AVIRULENCE FACTOR AVR AVRRPT-CLEAVAGE: CLEAVAGE SITE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15804" checksum="E0CB0B3FC0308C7E" modified="2016-04-13" version="1">MTYYRRNQIPAFGSWNCNDDLPFTQCFESATQPGLISCSYTEDRDLYVAGDLYRNNIVTPAIIVAPRRRGYTKEVKKDAWVANCDCDEKKEAPTPVARSRKAVDEDLYKISPELLRAKPRRRRWGWFSSCMLPACVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNH3</accession>
    <name>A0A103YNH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloenzyme, LuxS/M16 peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNH3"/>
    <dbReference type="STRING" id="59895.A0A103YNH3"/>
    <dbReference type="Gramene" id="KVI12277">
        <property type="protein sequence ID" value="KVI12277"/>
        <property type="gene ID" value="Ccrd_009333"/>
    </dbReference>
    <dbReference type="OMA" id="PMSGRIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF34">
        <property type="entry name" value="ZINC PROTEASE PQQL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="669"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="973" mass="109411" checksum="E4ABFE271E5FE7C9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNN5</accession>
    <name>A0A103YNN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine carboxyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNN5"/>
    <dbReference type="STRING" id="59895.A0A103YNN5"/>
    <dbReference type="Gramene" id="KVI12429">
        <property type="protein sequence ID" value="KVI12429"/>
        <property type="gene ID" value="Ccrd_009085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE YKTD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619:SF2">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="28400" checksum="BABD5409B0D04C78" modified="2016-04-13" version="1">MEIRCFLVRCFLPTPPLIRHQSLFWESTNNSSRRNNKNGGLKVTAKSNIHEDGDHDHPFFQSAFSRASYRFHETLRPEPLFVDPYAGCFVPPNLELDETTKQKMHHYCIGTRFIDDQLLSVTKGVDGAKQVVLFTDGMDTRAYRLNWPSSTVIYDVSPQAVFKKASEKLKDVGAKIPRSCLLVHVPLESSDMQQVLRDKGFNGCRPKHLQFSDDQKNLSDLAALPIPMTSPIPFVSALIGVNTERSYDTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSI4</accession>
    <name>A0A118JSI4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor, SBP-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_008769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005285">
        <property type="protein sequence ID" value="KVH89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSI4"/>
    <dbReference type="STRING" id="59895.A0A118JSI4"/>
    <dbReference type="Gramene" id="KVH89244">
        <property type="protein sequence ID" value="KVH89244"/>
        <property type="gene ID" value="Ccrd_008769"/>
    </dbReference>
    <dbReference type="OMA" id="LERDWHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1100.10:FF:000001">
        <property type="entry name" value="Squamosa promoter-binding-like protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1100.10">
        <property type="entry name" value="Transcription factor, SBP-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044817">
        <property type="entry name" value="SBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004333">
        <property type="entry name" value="SBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036893">
        <property type="entry name" value="SBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251">
        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251:SF225">
        <property type="entry name" value="TRANSCRIPTION FACTOR, SBP-BOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03110">
        <property type="entry name" value="SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103612">
        <property type="entry name" value="SBT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51141">
        <property type="entry name" value="ZF_SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SBP-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="39168" checksum="0AD49A04A0D68FE9" modified="2016-04-13" version="1" fragment="single">KPPRSFLLKNPTVFSSLNHSHTYKWKVDGGTLSTPVAVAATTVVESVVHALLFGVADSNDGGVIHLQDNRRLYGGIGSINHRIPDPHMMCLKLGKRHYCEDAVVPDRHVLAAESSFSSTKRAGKPPYPYYVCDSTTTAIPGVRTPSSPATVARCQVEGCHVALTNAKEYYKRHKVCEIHSKAPKVVVLGLQQRFCQQCSRFHGVTEFDEAKRSCRRRLEGHNQRRRKGTLPTLPPHSKPGCALSLLSSPKIEPWISSGDLSSRCSAALCELIAANRATTVVGHLWNQNSSHQPVVEDTIQTLPNTQMWDRFNDKDTSMTLDLMQAPALDVGLLSMKEKAKDHEDWNDYCWSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTA0</accession>
    <name>A0A118JTA0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005264">
        <property type="protein sequence ID" value="KVH89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTA0"/>
    <dbReference type="STRING" id="59895.A0A118JTA0"/>
    <dbReference type="Gramene" id="KVH89291">
        <property type="protein sequence ID" value="KVH89291"/>
        <property type="gene ID" value="Ccrd_008721"/>
    </dbReference>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF27">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="37782" checksum="B17FE6F4F80C13A0" modified="2016-04-13" version="1">MVLLVNISNMAFKNALIAFMAPLPSIIFYISFLNHYQLQHDDDGDDNLQLLSPLWNWCYQHPLLLANTLFFFNIDVGFWLISLLQSSNWMIDLYWTVIPVLLVHLFANHPNAEYNQWRSMVVVVLTWVWATRLTHNYFRREKWQWGAREDWRFTNMAEQHGQNWWWVSFFGVYLIQQPLNIWDIIAVIVCMSGIVYAYLADTQLHTFVSKNERLKEEGKAMVPNLDEGLWYYSRHPNYFGEQLWWWGLAIFGWNLGCTWAFVGALMNTLCLAYVTTLVEKRMLKQEYRVVAYKMYQKTTSIWVPWFKSSPKPSIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV71</accession>
    <name>A0A118JV71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004809">
        <property type="protein sequence ID" value="KVH92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV71"/>
    <dbReference type="STRING" id="59895.A0A118JV71"/>
    <dbReference type="Gramene" id="KVH92711">
        <property type="protein sequence ID" value="KVH92711"/>
        <property type="gene ID" value="Ccrd_005245"/>
    </dbReference>
    <dbReference type="OMA" id="DLMSTME"/>
    <dbReference type="OrthoDB" id="988630at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044293">
        <property type="entry name" value="PRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46446:SF33">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX (BHLH) DNA-BINDING FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46446">
        <property type="entry name" value="TRANSCRIPTION FACTOR PRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23174">
        <property type="entry name" value="bHLH_ILI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="88" mass="10007" checksum="27021DF268461890" modified="2016-04-13" version="1">MSSRRSREAPRITDDQIIQLLSKLQQLLPEIRNRRSNKASASKVLQETCNYVRSLHQEVDDLSDRLSQLLSTVDANSPEASIIQSLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVL4</accession>
    <name>A0A118JVL4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004790">
        <property type="protein sequence ID" value="KVH93247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVL4"/>
    <dbReference type="STRING" id="59895.A0A118JVL4"/>
    <dbReference type="Gramene" id="KVH93247">
        <property type="protein sequence ID" value="KVH93247"/>
        <property type="gene ID" value="Ccrd_004723"/>
    </dbReference>
    <dbReference type="OMA" id="DTEMKEW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000433">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000561">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase At2g16250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000448">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF81">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159716" evidence="8">
        <location>
            <begin position="20"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="488"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="838" mass="91595" checksum="6933A61823319043" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVX8</accession>
    <name>A0A118JVX8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_004735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SFH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004791">
        <property type="protein sequence ID" value="KVH93205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVX8"/>
    <dbReference type="STRING" id="59895.A0A118JVX8"/>
    <dbReference type="Gramene" id="KVH93205">
        <property type="protein sequence ID" value="KVH93205"/>
        <property type="gene ID" value="Ccrd_004735"/>
    </dbReference>
    <dbReference type="OMA" id="AEWHEEK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF29">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL_PHOSPHATIDYLCHOLINE TRANSFER PROTEIN SFH12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="157"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH93205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="527" mass="59935" checksum="7904E923ECDC1556" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWV8</accession>
    <name>A0A118JWV8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004473">
        <property type="protein sequence ID" value="KVH94992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWV8"/>
    <dbReference type="STRING" id="59895.A0A118JWV8"/>
    <dbReference type="Gramene" id="KVH94992">
        <property type="protein sequence ID" value="KVH94992"/>
        <property type="gene ID" value="Ccrd_002938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="27098" checksum="D474373D20840EFD" modified="2016-04-13" version="1">MISLHGARGFPFIEPKILEIEASLMKEGDGLPQEAEDCKHEHILKLEIPKAYICDFYKRHGTFWAFPRGCSSKEAVEGDQRRQREAATRGGDEQRRRAAAMSGGDDRPAGRRRQQANEPKKNENKQLDRIIEHPDGDVELRFSNNRVTRLKSLSSRFSTSDIPTSSYEKDSVIGTKFTKDEVCQPIYKIEIPNSSQSKTPNSPTASDMGYSEDYGINVLSKLEKEFSFSGKLEQEFYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXD1</accession>
    <name>A0A118JXD1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXD1"/>
    <dbReference type="Gramene" id="KVH96131">
        <property type="protein sequence ID" value="KVH96131"/>
        <property type="gene ID" value="Ccrd_001799"/>
    </dbReference>
    <dbReference type="OMA" id="LTIQAWT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="452" mass="49493" checksum="613E02E92E2707BC" modified="2016-04-13" version="1" fragment="single">MWIGRTNLPSKAAMGLVILTIQAHSPSLKPPECNPINVAVPCQDVHGAKATMLFLGLYLVALGVGGIKGSLPAHGAQQFDDNTVKGRKQRSTFFNYFVVCLAIGALIAVTFVVWIEDNKGWEWGFGISMLTVLLSIPVLIASMLNVNPSNAIASMTSLPPNNVEQQQTVSKDLEELETLSSSLRFLNRAALNKPAYNFLRCSVKQVEEVKVVLRVLPTFGCTIMLNCCLAQLSTFSVQQASTMNTKIGSLKVPAASLPVFPVIFIIVIGPIYNHIIIPFARKARKSEMGVSHLQRIGVGLLFSIMAMAIAALVEIKRKGIATRTGFDPSEPLPITFLWIAFQYLFLGSADLFTLAGLMEFFFTEAPASMKSLATSLSFASLAMGYYLSTVMVSIVNSATGSSGHPGWLSGGNLNQYHLERFYWLMCVLSGLNFLHYLFWAHRYKYQSIGARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K076</accession>
    <name>A0A118K076_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NUCLEAR FUSION DEFECTIVE 6, chloroplastic/mitochondrial-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003140">
        <property type="protein sequence ID" value="KVI01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K076"/>
    <dbReference type="STRING" id="59895.A0A118K076"/>
    <dbReference type="Gramene" id="KVI01020">
        <property type="protein sequence ID" value="KVI01020"/>
        <property type="gene ID" value="Ccrd_020715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043459">
        <property type="entry name" value="NFD6/NOXY2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156">
        <property type="entry name" value="OS02G0230000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156:SF59">
        <property type="entry name" value="PROTEIN NUCLEAR FUSION DEFECTIVE 6, CHLOROPLASTIC_MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15615" checksum="5572AAA2E753524F" modified="2016-04-13" version="1">MAAVFAGRSVLRSASTGVRSSASRISAGAKPSFTGAARSPFRVPARNPLSHRIFRSPVEKSCVALESMLPFHTATASALLTSMLSSAPYSCGWTIDGHTSKAKEKKKHEIIQIPSSKVFFEIYVGMLTIIRCPFDCFPGGFVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5W2</accession>
    <name>A0A118K5W2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tryptophan/tyrosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5W2"/>
    <dbReference type="Gramene" id="KVI09763">
        <property type="protein sequence ID" value="KVI09763"/>
        <property type="gene ID" value="Ccrd_011886"/>
    </dbReference>
    <dbReference type="OMA" id="LVKYYDR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32195">
        <property type="entry name" value="OS07G0662800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32195:SF24">
        <property type="entry name" value="TRYPTOPHAN OR TYROSINE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="498" mass="53644" checksum="DC668F8BB9F441A2" modified="2016-04-13" version="1">MKSSFWNSLPPAVSSSSSLLFKFVGLFFLTFQPFPPRLEILGEDSQLKRTLKKQNKGDDSGIPIAVSGTKKGTIAGAVALIIGTSIGSGILALPKRTSPAVTRHAGALEFGNCASGSHGLLPSSISLILCWGFLLIEALLLVEINVGLLKKKENRVENENENELEVISIRTMAQETLGELGGTLATLTYVFLGYTSMIAYASKSGEILYHFIKIPESVSGVFFTMVFAILISGGGTRTTDQVNQVLTVCMIGLLVAIEVLAIFYGGWAGFEGNGDWTKVPATIPVMIFSLVYHDLAPVLCAYLGGDIERIRTSVVLGSVVPLAGILIWNAVALGLSSQTEPIIDPLELLMRQRWDGVQIMVEAFSLLAVGTSLLGTLLGFSQFFKEQIKSRTDFGGMVEKWWVNNRTGFTATVMVIGPTLFVSTTVPDVFSAATDIAGGYCMTMLYGVLPPAMAWAMHVEEETDDKKGISRTRLALFGIGLFACGIILEQIFLDLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6B3</accession>
    <name>A0A118K6B3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001021">
        <property type="protein sequence ID" value="KVI10365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6B3"/>
    <dbReference type="STRING" id="59895.A0A118K6B3"/>
    <dbReference type="Gramene" id="KVI10365">
        <property type="protein sequence ID" value="KVI10365"/>
        <property type="gene ID" value="Ccrd_011230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36405">
        <property type="entry name" value="BNAA10G09140D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36405:SF1">
        <property type="entry name" value="OS07G0520600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="323" mass="35309" checksum="D7D1050090504373" modified="2016-04-13" version="1">MVEPMLKAAIEISTLLARSFFMGFSMTVLALLARLRVLTQQILLDVVSVFNMVSALSRKQQSIKLNQEGIEAFHSSIYNKSVDITLDKAPEEDTGTIRMDDLSSMEGLSNDCKQVDGSGFSEPASKNLEHEETTNSSCILVPGIQRILTSDFRTFMEVNVDQDNQQHMVQTLEAIKGGGGSIKVGSTGTINALMTRELQSIKVASPKTALEPTDAATDTKPKADEASTSSSNTMNEKHTSIPQKTKHHHTRKGSRNPILHHSDSVSVDGSGSPNRRKTDKKGSCMVEIVDIKCGVPDKNWANPITNRFKKLSFSKLSETNGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6C9</accession>
    <name>A0A118K6C9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001019">
        <property type="protein sequence ID" value="KVI10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6C9"/>
    <dbReference type="STRING" id="59895.A0A118K6C9"/>
    <dbReference type="Gramene" id="KVI10483">
        <property type="protein sequence ID" value="KVI10483"/>
        <property type="gene ID" value="Ccrd_011133"/>
    </dbReference>
    <dbReference type="OMA" id="VENDIYP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="38256" checksum="1A6D00CCD8282929" modified="2016-04-13" version="1">MSAMEEDYSVDASKLLQAASDFSFDPGTRSEAAVKEFIGSFPLPVIINALQTKGDVPGLEDALVDCLEKIFRTKYGASLIPEYMPFIVVGLQAYSQRVITLACKTISSLLENLDDTGFATSLIKENCAYPLLLNCLIDGDEQVAVAATDAIRTLASSQQGIEIIFPATPSETTDITKLAARCSSMGRVRVLALIVKLFSTSSAVASLVYNSNLLGLMEAEVRNTKDTLMTLSMLELLYEVCHYSVIVSLPVYLQPLHDLAEVQHGMEYVLRTNILQLLISIIRNSSAESMLRSRAMMISGRLLSKENVLMFIDESSIKAVISAIDERLSLLDNQDADECECGLEAIGQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7I1</accession>
    <name>A0A118K7I1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidative stress 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7I1"/>
    <dbReference type="STRING" id="59895.A0A118K7I1"/>
    <dbReference type="Gramene" id="KVI12273">
        <property type="protein sequence ID" value="KVI12273"/>
        <property type="gene ID" value="Ccrd_009319"/>
    </dbReference>
    <dbReference type="OMA" id="KENDKSH"/>
    <dbReference type="OrthoDB" id="694201at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF104">
        <property type="entry name" value="OS02G0227100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18099" checksum="E6C4418BF83A3AE8" modified="2016-04-13" version="1">MGEVEKRQIGQEMGLKEEDKNGVQWDLMETKDGVCRYDISESDSEDLDESSSSSETIEDASSSSSSLSSYGPLFELSELMAELPIKRGISKFYQGKSESFASLTSVKSIEDLAKKGKYSCRSRRSMKSSYGGGQHQRLSPKATIGKNKKASMFSSLGKMSSLMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCJ0</accession>
    <name>A0A124SCJ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004586">
        <property type="protein sequence ID" value="KVH93896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCJ0"/>
    <dbReference type="STRING" id="59895.A0A124SCJ0"/>
    <dbReference type="Gramene" id="KVH93896">
        <property type="protein sequence ID" value="KVH93896"/>
        <property type="gene ID" value="Ccrd_004041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034256">
        <property type="term" value="F:chlorophyll(ide) b reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010304">
        <property type="term" value="P:PSII associated light-harvesting complex II catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052625">
        <property type="entry name" value="Chl_b_Red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24314:SF21">
        <property type="entry name" value="CHLOROPHYLL(IDE) B REDUCTASE NYC1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24314">
        <property type="entry name" value="NON-SPECIFIC LIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="45978" checksum="5C6A6EEC6EB9D7D1" modified="2016-04-13" version="1">MAAVAQFHMFPANPHHKTTQSPVTQLGFCRSSVLWEPIPPFSGRKVCLQPCRSFRSEEGKNGGGKEKGNTRRNVLGAIKSLILSNDNSMEKLEEKLSRIYCDDDEHRSDFVNWIQFIGNIDVKSLNEGGDGQMNDLIWYSWVGGIIIGTMIGSNMVLDEVSRAGPRNVVITGSTRGLGKALAREFLLSGDRVVIASRSEKSVDMTIKELEENLQEGMATAMSSSRKNLVNAKVVGTSCDVCDPEDVRNLADFAVNELGSIDIWINNAGTNKGFRPLLQFTDEDIKQNKQMFNIICELPETVARTLVPRMRVVKGSGKAINYLTPPRILLALVTAWLRRGRWFDDKGRALYAAEADRLRNWAESRARFSFTDAMEMYTENTWVSVFSLSVVCAFIILSSTTGNASGHIDNFHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCJ1</accession>
    <name>A0A124SCJ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004584">
        <property type="protein sequence ID" value="KVH93942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCJ1"/>
    <dbReference type="Gramene" id="KVH93942">
        <property type="protein sequence ID" value="KVH93942"/>
        <property type="gene ID" value="Ccrd_004003"/>
    </dbReference>
    <dbReference type="OMA" id="VEVAANC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="341" mass="37510" checksum="077B057F06493C7A" modified="2016-04-13" version="1">MLKENTTKEKRVEERKALWPNNKRMALFQERINRRVVVEEMRTGCQILVVVVLRMPELGADDGLGVVNGGGLVEVEAVMVMEVVVCIQCKEVVVVEVLYKEVVMVEVENVAMVEVENGGMVAVGVMNKYMSEVVEVNGVVEVNGVVEAVNGVAEESVVEVVNCSSKEWVVVGNTRVEAVEMQPEEVVEVILHNKEELLQVVAGMVVVAMVGAEMVMGEVEKEVEVTVVVEKEVEVTVVVEKEVEVTVVVERVVEVVVTLPEAEEMEVGEMVVVVMVEVVMVEVVMVAVEVEETVRVGCKQEVVEEMESQQVAKESQQAATAPAQEETAVVVREAPEQMEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCU0</accession>
    <name>A0A124SCU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING-CH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004516">
        <property type="protein sequence ID" value="KVH94840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCU0"/>
    <dbReference type="STRING" id="59895.A0A124SCU0"/>
    <dbReference type="Gramene" id="KVH94840">
        <property type="protein sequence ID" value="KVH94840"/>
        <property type="gene ID" value="Ccrd_003098"/>
    </dbReference>
    <dbReference type="OMA" id="SCYSQFF"/>
    <dbReference type="OrthoDB" id="1912066at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214:SF42">
        <property type="entry name" value="RING-CH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214">
        <property type="entry name" value="ZINC FINGER, RING-CH-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="222" mass="23805" checksum="4037918AA01F9D82" modified="2016-04-13" version="1">MANSEMAGIDLECGGGETSRRSTSDENNQCFSDAEEGSCYSQFYSTYGDANYDDPEIGHVSRRVSSAGSDCSVDVLGDDEGKVVIVHLGMKLDKRDCRICQLSLVDDGDGDAIELGCCCKDDLAAAHKHCAETWFKIKGNKICEICNSIVSNLVVPNETLLGHGTMDVNPVATSVATAHVSAATAIRGGRGCINGHRLLNFILACLVFAFVISWLFHFNIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCU4</accession>
    <name>A0A124SCU4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004507">
        <property type="protein sequence ID" value="KVH94900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCU4"/>
    <dbReference type="STRING" id="59895.A0A124SCU4"/>
    <dbReference type="Gramene" id="KVH94900">
        <property type="protein sequence ID" value="KVH94900"/>
        <property type="gene ID" value="Ccrd_003042"/>
    </dbReference>
    <dbReference type="OMA" id="ASCVIFY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="544" mass="61258" checksum="9D4CB9346AA5F195" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDV2</accession>
    <name>A0A124SDV2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDV2"/>
    <dbReference type="STRING" id="59895.A0A124SDV2"/>
    <dbReference type="Gramene" id="KVH98092">
        <property type="protein sequence ID" value="KVH98092"/>
        <property type="gene ID" value="Ccrd_023691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH98092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13867" checksum="80404AF0414379C2" modified="2016-04-13" version="1" fragment="single">LEKAHFPGAQKAEKGHKWRQWRWDWRRSEGEKVEMAKSCKGLAMELVKCLSESDCVKIDDLDKCDNCCEFTMRNASHRRKFSLVCVNSVIDPNIYSGGFITLASAETMPNYNEELRIVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGF3</accession>
    <name>A0A124SGF3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cycloeucalenol cycloisomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001845">
        <property type="protein sequence ID" value="KVI06182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGF3"/>
    <dbReference type="STRING" id="59895.A0A124SGF3"/>
    <dbReference type="Gramene" id="KVI06182">
        <property type="protein sequence ID" value="KVI06182"/>
        <property type="gene ID" value="Ccrd_015451"/>
    </dbReference>
    <dbReference type="OMA" id="KIRWATE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047793">
        <property type="term" value="F:cycloeucalenol cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020532">
        <property type="entry name" value="Cycloeucalenol_cycloisomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35136">
        <property type="entry name" value="CYCLOEUCALENOL CYCLOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35136:SF1">
        <property type="entry name" value="CYCLOEUCALENOL CYCLOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27311" checksum="AD205AAB66FB7DA2" modified="2016-04-13" version="1">MGGSEKVVAVECSSSLWLASNPSKRWGELFFLLYTPFWLTLCLGIVVPYKLYEDFKELEYLLLGLISVLPAFLLPIFMVGKASLWIIIFSYVGNYFWTHYFFTVLGASYTFPSWKMNNVPHTTFLLTNVCFLFYHVTSNMTLRRLQHSVAHLPVKTQWIIKSAWILALSYFIAYLETVAISNVDPWDLPRVAIDALGAAMLVTIILDLWRLFLGPIVSVADTKQCAQPGLPWFPVHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGI7</accession>
    <name>A0A124SGI7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_015144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001814">
        <property type="protein sequence ID" value="KVI06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGI7"/>
    <dbReference type="STRING" id="59895.A0A124SGI7"/>
    <dbReference type="Gramene" id="KVI06511">
        <property type="protein sequence ID" value="KVI06511"/>
        <property type="gene ID" value="Ccrd_015144"/>
    </dbReference>
    <dbReference type="OMA" id="SHTICYE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF22">
        <property type="entry name" value="CYTOCHROME P450 83B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176236" evidence="16">
        <location>
            <begin position="20"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="487" mass="56171" checksum="9F825ADFA4D70BD6" modified="2016-04-13" version="1">MALLFLFLFLSVPLLYLLSRTFISKSRFNPPGPPRLPFIGNLHQIDLSNLHTSLWHISKSYGPIISLRFGFIPAIVVSSARLAKEVLKTQDIIFCSRPPLRGQLKVSYDGLDVAFSPYNKNWREMRKILMLHLLGPKRIQSFRHIREDDVSTTMKNIHELALSFKHVNLSEIMKSMTSNMMLRVGFGMRYQDGNERKEVLQLLTEFQAVLAKLFFSDLWPGLPFVGLVDRLLGKVDQVEKCFKYFDSFYQQLIDEHLNLQNPNKSHDREEEDFIDILLRLKKDQLFNLTYDHIKAMLMNVLVAGTDTIAVTVVWAMTALIKNPKVMKKAQEEVRNVVGKKGKVDEDDLPKLTYLKAVVKETLRLYPPAPLLIPRETTKDAILHGYKIKQKTLVFVNALAIGRDPECWESPELFLPERFMGSNIDFRGNDFEFIPFGGGRRICPGISMGDVMVDLLLANLIYLFDWNLPDGMRKEDVDFEVNSYFEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGU9</accession>
    <name>A0A124SGU9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRIP/coiled-coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGU9"/>
    <dbReference type="STRING" id="59895.A0A124SGU9"/>
    <dbReference type="Gramene" id="KVI07532">
        <property type="protein sequence ID" value="KVI07532"/>
        <property type="gene ID" value="Ccrd_014119"/>
    </dbReference>
    <dbReference type="OMA" id="GPDWWPY"/>
    <dbReference type="OrthoDB" id="779178at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37223">
        <property type="entry name" value="OS08G0528601 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37223:SF1">
        <property type="entry name" value="OS08G0528601 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8420" checksum="53AADD0B9E2C1D2C" modified="2016-04-13" version="1">MAKRSGSARRRDGESLLTRAVDSVFGFVRYAEFEILFVLFFVIAFVIFKDLTSRPEYNQILVKKPGGPDWWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGW3</accession>
    <name>A0A124SGW3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001498">
        <property type="protein sequence ID" value="KVI07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGW3"/>
    <dbReference type="STRING" id="59895.A0A124SGW3"/>
    <dbReference type="Gramene" id="KVI07667">
        <property type="protein sequence ID" value="KVI07667"/>
        <property type="gene ID" value="Ccrd_013972"/>
    </dbReference>
    <dbReference type="OMA" id="YGVERFW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47712:SF2">
        <property type="entry name" value="F-BOX DOMAIN, GALACTOSE OXIDASE, BETA-PROPELLER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47712">
        <property type="entry name" value="OS09G0555300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="543" mass="61432" checksum="1EE7625D250D5112" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI21</accession>
    <name>A0A124SI21_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar cation/proton exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_010232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000289">
        <property type="protein sequence ID" value="KVI11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI21"/>
    <dbReference type="STRING" id="59895.A0A124SI21"/>
    <dbReference type="Gramene" id="KVI11358">
        <property type="protein sequence ID" value="KVI11358"/>
        <property type="gene ID" value="Ccrd_010232"/>
    </dbReference>
    <dbReference type="OMA" id="CYCELET"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000020">
        <property type="entry name" value="Vacuolar cation/proton exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF1">
        <property type="entry name" value="VACUOLAR CATION_PROTON EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="14">
        <location>
            <begin position="97"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="14">
        <location>
            <begin position="280"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="445" mass="48063" checksum="548F34A13D06A1AD" modified="2016-04-13" version="1">MASIQPAEPWLLENGTVKRLTKETRHGHGHSRTAHNKSSSSLRRKSNMTLVSKVPCATIRNFLANLQEVILGTKLAILFIAIPLAIAAKYLGFARPWVFSLSLLGLMPLAERVSFLTEQLSYYTGATVGGLLNATCGNATELIIAIFALMENKVDVVKYSLLGSILSNLLLVLGTSLLCGGIANVSVEQKFDRKQADVNIALLLLGLLCHLLPLMYRYASLETPLATAAATLNLSRASCIVMLVAYLAYLVFQLFTHRHIFESQEDEDGMGASEEETPVIGFWSGLIWLIGMTAVISLLSEYLEASTSWGISVSFISIILLPIVGNAAEHAGAVIFAFKNKLDITLGVALGSATQISVPMSVIVAWIVGIKMDLDFNLLETGSLALTIIATAFTLQDGTSHYLKGVVLLLCYFIIGASFFVSVSPIGDDVVTMGLESSNQKIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RKC4</accession>
    <name>A0A103RKC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Coatomer, epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_026269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007777">
        <property type="protein sequence ID" value="KVG69397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103RKC4"/>
    <dbReference type="STRING" id="59895.A0A103RKC4"/>
    <dbReference type="Gramene" id="KVG69397">
        <property type="protein sequence ID" value="KVG69397"/>
        <property type="gene ID" value="Ccrd_026269"/>
    </dbReference>
    <dbReference type="OMA" id="YVWRSYL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVG69397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="11171" checksum="C4DF7213954CA6B6" modified="2016-04-13" version="1">MAMVPDLLFNLRNNFYLGAYQAAINISDIKNLSEEDSIERDCLVYRSYIALGSYQLVIDEIDSSATTPLQAVKLLALYLSIPEKKVGFLLINFVSSFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UAG6</accession>
    <name>A0A103UAG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="5">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01006930">
        <property type="protein sequence ID" value="KVH32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UAG6"/>
    <dbReference type="STRING" id="59895.A0A103UAG6"/>
    <dbReference type="Gramene" id="KVH32027">
        <property type="protein sequence ID" value="KVH32027"/>
        <property type="gene ID" value="Ccrd_025826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23732" checksum="F7092809253CD09B" modified="2016-04-13" version="1">MLLLPSKSETNVLRQRHATGPEDAPFETLVLPHPDRVISNVRLLHSAFSFIPKTRAPQLMPTGGFTYRKLTHKIFGSCPPMQSFDPAKMLGNHRACSFVCADDQDVEYYRGFWREYRYYSRTSPMKHVLISFCLCLFVEYESWCGGLGINLTAADTVIFYESVWNPTLDLQAMDRAHRLGQTKDASFFLLPLLHLEKFKCHVFQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X5L5</accession>
    <name>A0A103X5L5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006381">
        <property type="protein sequence ID" value="KVH84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X5L5"/>
    <dbReference type="Gramene" id="KVH84540">
        <property type="protein sequence ID" value="KVH84540"/>
        <property type="gene ID" value="Ccrd_025451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="195" mass="20831" checksum="DA089B89CED47DA6" modified="2016-04-13" version="1">MQAVGVGVGVGALLSYATGTFTGYLSIQSAHGLPSHPPGIVFSALHTALLHLKPDPNAICHTRSPFETRPFASAYDNSYHNELLDVFPNRCSVILDGSMCLSVRFKFFSISSSTALPPAWMQKCSNASLKSGIYGFTFIFNTFLFTSVTKNINCSENGSTRGPNVVIFVLSASPATAISSRASETPTIPLSSSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE16</accession>
    <name>A0A103XE16_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aluminum-activated malate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aromatic acid exporter (TC 2.A.85) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005321">
        <property type="protein sequence ID" value="KVH89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE16"/>
    <dbReference type="STRING" id="59895.A0A103XE16"/>
    <dbReference type="Gramene" id="KVH89000">
        <property type="protein sequence ID" value="KVH89000"/>
        <property type="gene ID" value="Ccrd_009005"/>
    </dbReference>
    <dbReference type="OMA" id="AITIMKM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="43244" checksum="2C296D0C5351EB05" modified="2016-04-13" version="1">MPSNGPEWNVNVAAVSPQVELGVAKRIFRQLQGQIFECWMKIRTFFNKARNIAANEPKKVIHGLKVGMALSLVSLFYYMRPLYDGVGGNAMWAVMTVVVALEYSVAAAATFSRFIPSVRARFDYGVMIFILTFSFVSMSGYRVDKLLELARNRVSTIAIGTSICILTSMLFYPVWAGKELHNLIYHNLEKLADSLDGCVRDYFKDNEERFSRKQEGYKCVLNSKATEEAMKHLKEVCMTLSSCSSNVLKELAMTMQTMTKSTKTEFFVQEMNFAVQSFQNVFKELLKQPVLLPVAEADEQNSRTCKGEMSQKPQIVPIMGIFPLATMASLLTEIAEQVEGIVAEVDEMAAQAEFYVVNYKEKKGNKLPKFNQDHVILTSLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF08</accession>
    <name>A0A103XF08_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_008459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005201">
        <property type="protein sequence ID" value="KVH89550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF08"/>
    <dbReference type="STRING" id="59895.A0A103XF08"/>
    <dbReference type="Gramene" id="KVH89550">
        <property type="protein sequence ID" value="KVH89550"/>
        <property type="gene ID" value="Ccrd_008459"/>
    </dbReference>
    <dbReference type="OMA" id="EMEIYPP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000035">
        <property type="entry name" value="RNA polymerase II C-terminal domain phosphatase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF0">
        <property type="entry name" value="RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="FCP1 homology" evidence="10">
        <location>
            <begin position="139"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="713"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="812"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH89550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="918" mass="103368" checksum="7C98979ACEBB7851" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG45</accession>
    <name>A0A103XG45_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May function as a signaling molecule by regulating the trafficking of other regulators.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG45"/>
    <dbReference type="STRING" id="59895.A0A103XG45"/>
    <dbReference type="Gramene" id="KVH90061">
        <property type="protein sequence ID" value="KVH90061"/>
        <property type="gene ID" value="Ccrd_007905"/>
    </dbReference>
    <dbReference type="OMA" id="YEADEMK"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd04022">
        <property type="entry name" value="C2A_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08378">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04019">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000323">
        <property type="entry name" value="C2 calcium/lipid-binding plant phosphoribosyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000119">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000128">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047257">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047258">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF52">
        <property type="entry name" value="MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="823"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="937"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="243"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="405"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="569"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="995" mass="113348" checksum="CC6391C3FDA75A0D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG52</accession>
    <name>A0A103XG52_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="LEKV01005115">
        <property type="protein sequence ID" value="KVH90154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG52"/>
    <dbReference type="STRING" id="59895.A0A103XG52"/>
    <dbReference type="Gramene" id="KVH90154">
        <property type="protein sequence ID" value="KVH90154"/>
        <property type="gene ID" value="Ccrd_007832"/>
    </dbReference>
    <dbReference type="OMA" id="THLDSMR"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="37540" checksum="B7E4AAA16953AA33" modified="2016-04-13" version="1">MQKTASSSTLGPDGLDIAQSFFKPIQGSFPPPPTSRNTKISVVGVGNVGMAIAQTILTQDLADEIALVDINADKLRGEMLDLQHAAAFLPRTKISASVDYSSTLGSDLVIVTAGARQIPGESRLNLMQRNLALFSKMIPPLAAGSPETILLIVSNPVDVLTYVAWKLSGFPSNRVIGSGTNLDSSRFRFLIADHLDLNAQDVQAYIVGEHGDSSVALWSSISVGGVPILSFLERQQIAYEKQTLEKIHKEVVQGAYEVISLKGYTSWAIGYSVASLARSILRDQRSIHPVSVLAKGFYGIDGGEPFLSLPAQLGRSGVLGVTNVHLTEEESQQLRESAKTILEVQSQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHH0</accession>
    <name>A0A103XHH0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mpp10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_007185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005093">
        <property type="protein sequence ID" value="KVH90782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XHH0"/>
    <dbReference type="Gramene" id="KVH90782">
        <property type="protein sequence ID" value="KVH90782"/>
        <property type="gene ID" value="Ccrd_007185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH90782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="318" mass="36400" checksum="68022258AFDAE2DD" modified="2016-04-13" version="1">MKELDENQSKKGLGEVYAKLCLKLDDLSHFHFTPKPVIEDMSIQTKVPALAMKEIAPLAVLDAAMLAPEEVFSGKGDIKEEAELTQEDRKRRRAHKKRNFKEALHCLKLTEPPMYLTPSSELATAARIASEHLFASVKPYTPKSPFDRLFQIDLQSQSLISAIRHQVNKFEKDPQELKDXFKSGESDQEQKREFVLEGEKEEEDEEDDELDDESNEEEDEDEDEIEEDESGDGERERKERGGVGVEDKLLNIQEMKESMEDDESREYGVNKKKQVVKKMARKFGEDDEEEDDDEDDDDELGVLELAGEEDMSDXEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHR8</accession>
    <name>A0A103XHR8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_007051</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHR8"/>
    <dbReference type="STRING" id="59895.A0A103XHR8"/>
    <dbReference type="Gramene" id="KVH90932">
        <property type="protein sequence ID" value="KVH90932"/>
        <property type="gene ID" value="Ccrd_007051"/>
    </dbReference>
    <dbReference type="OMA" id="RIFEHEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="61"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH90932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="40219" checksum="5FE96B635CC7634F" modified="2016-04-13" version="1" fragment="single">MGGCISVANASYVRRTRNSLVNPISEDDLMPETPTKPRTPRFVRPARVLKESAGKDIFRRYKFGKELGRGEFGVTYECQNIATGEKVACKKISKSKLRAEIDVEDVRREVEIMRHLPVHPNIVSYKDVYEDKDAIYLLMELCEGGELFDRIVAKGHYTERAAAIVIRTILEVCHKHGVIHRDLKPENFLYANKSETAPLKAIDFGLSIFIEPGVRFKEIVGSPYYMAPEVLRRNYGEEIDVWSTGVILYILLCGVVAENLPDEQVTGLKQMFHEMDKDNNGSLTFEELKEGLCSIGDQPLDDPDVRMLMEAADLDENGVLNCDEFMMIAVHLKRISNDDHLRQAFHYFDKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIL5</accession>
    <name>A0A103XIL5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005050">
        <property type="protein sequence ID" value="KVH91313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIL5"/>
    <dbReference type="Gramene" id="KVH91313">
        <property type="protein sequence ID" value="KVH91313"/>
        <property type="gene ID" value="Ccrd_006667"/>
    </dbReference>
    <dbReference type="OMA" id="CHRKRFD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33592">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33592:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118822" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7814" checksum="A00653323653A095" modified="2016-04-13" version="1">MKPSSTAYVFLVALVIFVVSDPIKAGRVLHEKDRLIDVKSGNMLVFQSLPRGPVPPAGPSGCTYIPGSHGPPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKJ1</accession>
    <name>A0A103XKJ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004824">
        <property type="protein sequence ID" value="KVH92318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKJ1"/>
    <dbReference type="STRING" id="59895.A0A103XKJ1"/>
    <dbReference type="Gramene" id="KVH92318">
        <property type="protein sequence ID" value="KVH92318"/>
        <property type="gene ID" value="Ccrd_005643"/>
    </dbReference>
    <dbReference type="OMA" id="AVANCIV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF17">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="421" mass="47396" checksum="2FA2C68ECB40D268" modified="2016-04-13" version="1">MAEEDHGVTRSLEELRQTFKSGRTRSIDWRKQQLRAILRLLHENEDVLFQSLESELGKHPVESYRDEIGVVKKSVDHALSCIDQWMSPKKGRLPLLFFPASGKVLPEPLGLVLIIGSWNFPITLTLDPLIGAISAGNTVVLKPSELAPKCASFLANKLPVYLDPKAIKVIEGGREVANQLLEYKWDKIFFTGSTKVGKIVMSAAAKHLTPVTLELGGKCPAILDSLPNSDMKIEQLKKTIKFFYGDDVTNLKNLAKIVNKTHFDRLRNLLEDPAVANCIVYGGSFDDTNLIIEPTILLDPPLDAEIMNEEIFGPLLPIITLENIEESIEFINSKPKPLALYAFTKNESFKKRILAETSSGSYSFDTFSHEKAVLERSFYFELEPRHPPWNNFKLDFLRLAYNFNYVGLVLHLLGLKRSSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKL2</accession>
    <name>A0A103XKL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histidine kinase-like ATPase, ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_005625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MORC ATPase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004822">
        <property type="protein sequence ID" value="KVH92348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKL2"/>
    <dbReference type="Gramene" id="KVH92348">
        <property type="protein sequence ID" value="KVH92348"/>
        <property type="gene ID" value="Ccrd_005625"/>
    </dbReference>
    <dbReference type="OMA" id="RHPETIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF50">
        <property type="entry name" value="PROTEIN MICRORCHIDIA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Morc S5" evidence="13">
        <location>
            <begin position="301"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH92348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="584" mass="66086" checksum="150CC028D7D01F4B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKY8</accession>
    <name>A0A103XKY8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA/rRNA methyltransferase, SpoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004810">
        <property type="protein sequence ID" value="KVH92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKY8"/>
    <dbReference type="STRING" id="59895.A0A103XKY8"/>
    <dbReference type="Gramene" id="KVH92671">
        <property type="protein sequence ID" value="KVH92671"/>
        <property type="gene ID" value="Ccrd_005288"/>
    </dbReference>
    <dbReference type="OMA" id="WDSTQEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000016">
        <property type="entry name" value="rRNA methylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="RRNA METHYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453:SF1">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="8">
        <location>
            <begin position="167"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="40092" checksum="4FCD8BB41F625A21" modified="2016-04-13" version="1">MNTCKFLRRCSLSCLDFSTTRIKTSTPLLHFSCHHRLSRNQGLGFRLKPYPNFSRAYVSIRSAVSIESTDAGCTSPEEEEEEDDDDERPTVRDLIWRNTNDDVSSFMKMERRTNGPQSNRWFPYLDQFKAGNTFLSSREVLDAVDPSLMDLRKERFMNVVNNRTYSVCLVVEGLSDAGNVSAVFRSADALGFQSVHVVSLDSRKRYREHRHVSMGAEKWLDIELWDTTKECFEVLKSRGYRIATTHVGIETVSVYDMDWSCPTAIVVGNEGSGISEEALKLSDMHCSIPMKGMVDSFNVSVASGILMHHAGGHGDLTPKEKQILLAEFSLRHSRSSISIAHEYAKRKIRSESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL34</accession>
    <name>A0A103XL34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pectinesterase</fullName>
            <ecNumber evidence="3 8">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_005276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3 8"/>
    <dbReference type="EMBL" id="LEKV01004809">
        <property type="protein sequence ID" value="KVH92728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL34"/>
    <dbReference type="STRING" id="59895.A0A103XL34"/>
    <dbReference type="Gramene" id="KVH92728">
        <property type="protein sequence ID" value="KVH92728"/>
        <property type="gene ID" value="Ccrd_005276"/>
    </dbReference>
    <dbReference type="OMA" id="HIYCKST"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000030">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF12">
        <property type="entry name" value="PECTINESTERASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="51"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH92728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="40987" checksum="7ACFF1D5B98B323B" modified="2016-04-13" version="1">MKEDLSSTHIQHQNPHHKFHPTVLLLEIIFQSFCRRYNSQEVRRRSMARVILVAHDGTGDYRTLQEAIDTVPFSNTRRTVIRLSPGIYKQPVYVPKTKNLITLAGLSPELTVITWNNTANKIDHHQPSRLIGTGTFGCGSTIVEGEDFIAENITFENSAPEGSGQAVAIRVTADRCAFYNCRFLGWQDTLYLHYGKQYLKDCYIEGSVDFIFGNSTALLEHCHIHCKSAGFITAQSRKSSQEATGYVFLRCVITGNGGTAYSYLGRPWGPFGRVVFAHTYMDACIKHHGWNNWGKTENERSACFYEYRCFGPGSGSDKRVTWARELVKEEAEQFLMHSFIDPNPERPWLAQRMALRVPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLF3</accession>
    <name>A0A103XLF3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Reticulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004802">
        <property type="protein sequence ID" value="KVH92908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLF3"/>
    <dbReference type="STRING" id="59895.A0A103XLF3"/>
    <dbReference type="Gramene" id="KVH92908">
        <property type="protein sequence ID" value="KVH92908"/>
        <property type="gene ID" value="Ccrd_005051"/>
    </dbReference>
    <dbReference type="OMA" id="AWFANTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044177">
        <property type="entry name" value="RTNLB22/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47879">
        <property type="entry name" value="RETICULON-LIKE PROTEIN B22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47879:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN B22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="201" mass="22245" checksum="07CFB49F6BA90BD2" modified="2016-04-13" version="1">MDQLNTNNAENEELLGRKRRKELGSVVIGKGKPLIVGMCATLVYYHCAYRNSSIVSLLSDVFIVLLCSLAILGLLFRQMNIQVPVDPLEWQISQDTANSLFACLANTVGAAESVLRVAATGHDKRLFLKVVVILYMLSALGRWVSGVTVAYAGLSLFCLYILAENSSFFSTCSSKFCWRRDSPNDVPYYYDRIPAGYGPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMU6</accession>
    <name>A0A103XMU6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_004529</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004770">
        <property type="protein sequence ID" value="KVH93419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMU6"/>
    <dbReference type="STRING" id="59895.A0A103XMU6"/>
    <dbReference type="Gramene" id="KVH93419">
        <property type="protein sequence ID" value="KVH93419"/>
        <property type="gene ID" value="Ccrd_004529"/>
    </dbReference>
    <dbReference type="OMA" id="GMSRNMH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000037">
        <property type="entry name" value="Chaperone protein dnaJ A6 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000009">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="11">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH93419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="49346" checksum="F7B806E750160815" modified="2016-04-13" version="1">MAIVPGGSTWVARWGVQPQLVSRASLTSKSFMHLPLVPINTRELASPCSAFCSQGSLHALCDMGSFGKSHHRRGGRLVVRAESDFYSVLGVSKNSSKAEIKSENGVLLVEKSNSVNPFSAYRKLARSYHPDVNKEPGAEQKFKDISNAYEVLSDDEKRSIYDRYGEAGLKGAGVGTGDFSNPFDLFESLFDGLGGMGGMGGMGGRSQRNRATQGEDQGYNLVLNFKEAIFGVEKEIEVTRLESCGTCNGSGAKPGTNASKCTTCGGQGQVISSARTPLGVFQQVMTCSSCNGSGEISTPCNTCSGDGRVRKSKRISLKVPAGVDAGSRLRVRSEGNAGRKGGPPGDLFVMIDVLSDPVLKRDDTNILYTCKITYIDAILGTTMKVPTVDGMVDLKIPSGTQPGTTLVMAKKGVPVLNKNNMRGDQLVRVQVEIPKRLSGDERKLIEELSNLKKGKVPNSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQD7</accession>
    <name>A0A103XQD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_002943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May glycosylate diterpenes or flavonols in leaves.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004475">
        <property type="protein sequence ID" value="KVH94986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH94986">
        <property type="protein sequence ID" value="KVH94986"/>
        <property type="gene ID" value="Ccrd_002943"/>
    </dbReference>
    <dbReference type="OMA" id="QRFVWVA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050404">
        <property type="term" value="F:zeatin O-beta-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016138">
        <property type="term" value="P:glycoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000238">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044:SF23">
        <property type="entry name" value="ANTHOCYANIDIN 3-O-GLUCOSYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="5">
        <location>
            <begin position="452"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="873" mass="98536" checksum="EBDF1567480F67DE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRF8</accession>
    <name>A0A103XRF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YABBY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004386">
        <property type="protein sequence ID" value="KVH95503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRF8"/>
    <dbReference type="STRING" id="59895.A0A103XRF8"/>
    <dbReference type="Gramene" id="KVH95503">
        <property type="protein sequence ID" value="KVH95503"/>
        <property type="gene ID" value="Ccrd_002427"/>
    </dbReference>
    <dbReference type="OMA" id="SCSDQLC"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010158">
        <property type="term" value="P:abaxial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010154">
        <property type="term" value="P:fruit development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009944">
        <property type="term" value="P:polarity specification of adaxial/abaxial axis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000024">
        <property type="term" value="P:regulation of leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902183">
        <property type="term" value="P:regulation of shoot apical meristem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000047">
        <property type="entry name" value="Axial regulator YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006780">
        <property type="entry name" value="YABBY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056776">
        <property type="entry name" value="YABBY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675:SF4">
        <property type="entry name" value="AXIAL REGULATOR YABBY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675">
        <property type="entry name" value="PROTEIN YABBY 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24868">
        <property type="entry name" value="YABBY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="YABBY N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="YABBY protein C-terminal" evidence="7">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="230" mass="25571" checksum="0310F81AB95B61D2" modified="2016-04-13" version="1">MSISSSTTSPTVPQLFHHLPPPSCSDQLCYVHCTHCDTVLAVSVPCTSLFKTVTVRCGHCTNLLPLNMPGLLLPPPVNQFHFGHTNFFSPSTHTLLDDQIPNGESNFLINQNYANDFSLTARGGFRELPKPPVTNRPPEKRQRVPSAYNRFIKEEIQRIKAGNPDISHREAFSAAAKNWAHFPHIHFGLMADQTNAANKTSMRQQDYHTDRGFMKDGLFAASANVGVSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS69</accession>
    <name>A0A103XS69_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wound-responsive family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004371">
        <property type="protein sequence ID" value="KVH95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS69"/>
    <dbReference type="Gramene" id="KVH95915">
        <property type="protein sequence ID" value="KVH95915"/>
        <property type="gene ID" value="Ccrd_002009"/>
    </dbReference>
    <dbReference type="OMA" id="GHKWKSG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022251">
        <property type="entry name" value="DUF3774_wound-induced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33090">
        <property type="entry name" value="DUF3774 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12609">
        <property type="entry name" value="DUF3774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9713" checksum="242FF87615D07E18" modified="2016-04-13" version="1">MTSLSRVWMAAGVAVINGHSDQACKLKSLIKSFRQGKKAFASSSSSDHPPSDLRPLSGFLGSTVDLRDRKTRSDDSLRQVIYLTCWGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSF8</accession>
    <name>A0A103XSF8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_001932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSF8"/>
    <dbReference type="STRING" id="59895.A0A103XSF8"/>
    <dbReference type="Gramene" id="KVH95984">
        <property type="protein sequence ID" value="KVH95984"/>
        <property type="gene ID" value="Ccrd_001932"/>
    </dbReference>
    <dbReference type="OMA" id="EWYPRAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH95984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="18891" checksum="38999E91B47F9A85" modified="2016-04-13" version="1">MSGAASYLARRAAQKERVRILYRRALKDTLTWAVHRHLFYPDADALRERFDANKNVASQQALLAATQETLAKVVEALVTLNNNKDVASANFSALVPAAAETHISHAHFLSEDIDTIDRMIADGEGQYNKWRHPDPYIVPWAPGGSKFTRNPTPPSGIEIVYDYGREDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTB4</accession>
    <name>A0A103XTB4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOD1/MUCI70 glycosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004275">
        <property type="protein sequence ID" value="KVH96515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTB4"/>
    <dbReference type="STRING" id="59895.A0A103XTB4"/>
    <dbReference type="Gramene" id="KVH96515">
        <property type="protein sequence ID" value="KVH96515"/>
        <property type="gene ID" value="Ccrd_001386"/>
    </dbReference>
    <dbReference type="OMA" id="PTMKVHC"/>
    <dbReference type="OrthoDB" id="1905162at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006852">
        <property type="entry name" value="TOD1_MUCI70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048354">
        <property type="entry name" value="TOD1_MUCI70_glycTrfase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12956">
        <property type="entry name" value="ALKALINE CERAMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12956:SF22">
        <property type="entry name" value="OS06G0724300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04765">
        <property type="entry name" value="TOD1_MUCI70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="TOD1/MUCI70 glycosyltransferase-like" evidence="2">
        <location>
            <begin position="136"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="499" mass="57703" checksum="EF15528438D63C67" modified="2016-04-13" version="1">MENDVHRSVSLRASRRPDRFYNNFEMKGADGFFDDKSSSDYPIKVIWKRGFVRLLLVGGILWMMLILAVLLFHIWSCQSSLVFLSAICNKDSTVFHMLHNMGMVTPPHRCSIPLANDPEKIVIPEKRSPSKFVQSLSYFEEDDANTNGSESSPLFGGHQSWKQREESFKLKSSMMVHCGFMRNGGADMSPKDIDYVKRCKFVVASGIFDGYDAPHQPSNVSLRSRKLFCFLMVVDEISLEFIKQNVTVREDGDKGQWVGIWRLILLKNPPYDEPRRNGKVPKILTHRLFPQALYSIWIDGKMELIVDPLLMLERYLWRGRHTFAIAQHKHHKSIYEEADSNKRRKRYARPLIDHHIKIYRYEGLDPWSPLKKTKSDVPEGAIIIREHTALNNLFSCLWFNEVNLFTPRDQLSFGFVVYRLKGNFNFFMFPNCEYNSIFILHPHTREHSSKIEWVKSLNELKGNNSGLKESRGGLGLWSPYPADLDLVVLPPVARTSKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTU5</accession>
    <name>A0A103XTU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004189">
        <property type="protein sequence ID" value="KVH96788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTU5"/>
    <dbReference type="STRING" id="59895.A0A103XTU5"/>
    <dbReference type="Gramene" id="KVH96788">
        <property type="protein sequence ID" value="KVH96788"/>
        <property type="gene ID" value="Ccrd_001122"/>
    </dbReference>
    <dbReference type="OMA" id="AYVELQM"/>
    <dbReference type="OrthoDB" id="1915848at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006943">
        <property type="entry name" value="DUF641_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056813">
        <property type="entry name" value="GIL1_IRKI_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04859">
        <property type="entry name" value="DUF641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24994">
        <property type="entry name" value="GIL1_IRKI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF641" evidence="2">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GIL1/IRKI C-terminal" evidence="3">
        <location>
            <begin position="392"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="51382" checksum="ED36FE0182DC091B" modified="2016-04-13" version="1">MDSRTTIKPTSASRSKFSKTFHKVLPFKKSTKSFSNNGFCLLLPHENKFKNYDSGSDSHRLFNKHSVDDAHLRNRAAMEAFVAKLFATISSLKAAYAELQAAQFPYSGEAVQCADQAVVDELKAISELKRSFLKKQIDSSPPHVTLLLSEIQEQQSLMKMYEITMNKMEREIKSKDFQLSSLRKQLVEADSTNISIETKLNSSGCFPILDNVNLSDLTPTNFIAVLHYALRSIRNFVKLLVRDMGNAHWDIDAAVKAIEPNVVFSKLSYRCFAIESYVAREMFVGFNDDDDEEEVEDRFQSFNHFKKMKSLTTTQLLKENPRSAFGKFTRAKYMRLVHPKMEASLYGNLSQRKTLNTWQFPDTAFFGAFTEMARRVWVLRCLASAFDKEVSVFEVRKGCRFSEVYMEAVTDEAFSGGQSGDELRVAFTVVPGFKIGETVVQSHVYVTAAVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUT1</accession>
    <name>A0A103XUT1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUT1"/>
    <dbReference type="STRING" id="59895.A0A103XUT1"/>
    <dbReference type="Gramene" id="KVH97258">
        <property type="protein sequence ID" value="KVH97258"/>
        <property type="gene ID" value="Ccrd_000637"/>
    </dbReference>
    <dbReference type="OMA" id="KEQWLFK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000004">
        <property type="entry name" value="probable cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001451">
        <property type="entry name" value="Putative cinnamyl alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000100">
        <property type="entry name" value="Putative cinnamyl alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH97258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="322" mass="34574" checksum="B60472C08339CDD0" modified="2016-04-13" version="1">MGSLPETEHPVKALGYAARDISGVLSPINFSRRETGDEDVRFKVSYCGVCHSDLHSVKNEWSNAKYPVIPGHEIVGVVTEVGSKVKKVKVGDKVGVGCMVGSCHSCDQCASDQEQYCLKMVQTYNDATMTTYGGYSDHMVANEHFIISWPENLPLDGGAPLLCAGITVYSPMRYYGLDKPGMHVGVVGLGGLGHVAVKFLKALGVKGAVGTMDGIIDTVSADHPLVPLIGLLRPNGKLVLVGAPTKPHEIPAFPLLFGRKLVGGSLIGGIKETQEMIDFAAKHNITAAIELIPIDYINTAMERLAKADVRYRFVIDVANTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUX6</accession>
    <name>A0A103XUX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-protein beta WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003838">
        <property type="protein sequence ID" value="KVH97333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUX6"/>
    <dbReference type="STRING" id="59895.A0A103XUX6"/>
    <dbReference type="Gramene" id="KVH97333">
        <property type="protein sequence ID" value="KVH97333"/>
        <property type="gene ID" value="Ccrd_000559"/>
    </dbReference>
    <dbReference type="OMA" id="PGISWEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="32488" checksum="9EF9919706137A34" modified="2016-04-13" version="1" fragment="single">GHKKWITGISWEPAHLKAPCRRFVSSSKDGDARIWDVTLRKTVIILSGHTLAVTCVKWGGDGVIYTGSQDCTIKVWETTQGKLIRELKGHGHWVNSLALSTEYVLRTGAFDHTRKQYSSPEEMKEAALERYNKMKGNAPERLVSGSDDFTMFLWEPSVSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGITGKFVAAFRGHVGPVYQIRFELRSLLYVININDVQLLTNCMVWDVRTQKLKQDLPGHADEVFAVDWSPDGEKVASGGRDRVLKLWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWV7</accession>
    <name>A0A103XWV7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWV7"/>
    <dbReference type="STRING" id="59895.A0A103XWV7"/>
    <dbReference type="Gramene" id="KVH98340">
        <property type="protein sequence ID" value="KVH98340"/>
        <property type="gene ID" value="Ccrd_023414"/>
    </dbReference>
    <dbReference type="OMA" id="NWYFNWS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="215"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="416" mass="46308" checksum="CEC3F9702A6BF6CA" modified="2016-04-13" version="1">MEERPETELISIPATPRDSTPEILTPSGHRSPRPQSKEGGKSWGIVSLTIAYFWQLYTLWILVQLHEAVPGKRYNRYVELAEAAFGETFSYSHRNRLGAWLSIFPTAYLSAGTATALIIVGGETMKLFFEIVCGPLCSSNPLTTVEWYLVFTSLCIVLSQLPNLNSIAGLSLVGAVTAIFYSTMVWVLSVSQPRPPNISYEPVPLPTFTASSTMPSTFKHPAHVPMWKGAKVAYFFIAMCLFPVAIGGFWAYGNLMPSGGILNAMFGFHEHDISRSLLAMTFLLVVFSCLSSFQIYSMPVFDNFEASYTHRTNRPCSVWVRSGFRVVYGFINFFIGVALPFLSSLAGLLGGLTLPVTFAYPCFMWVLIKKPTKYSFNWYFNWSLGWLGVAFSVAFTIGGIWSIVDSGLKLKFFKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWW9</accession>
    <name>A0A103XWW9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_023373</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01003799">
        <property type="protein sequence ID" value="KVH98408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWW9"/>
    <dbReference type="STRING" id="59895.A0A103XWW9"/>
    <dbReference type="Gramene" id="KVH98408">
        <property type="protein sequence ID" value="KVH98408"/>
        <property type="gene ID" value="Ccrd_023373"/>
    </dbReference>
    <dbReference type="OMA" id="HHSKLCG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="14">
        <location>
            <begin position="114"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="15">
        <location>
            <begin position="420"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036417-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH98408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="526" mass="58243" checksum="1028FE1F152CCCFC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXQ6</accession>
    <name>A0A103XXQ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003643">
        <property type="protein sequence ID" value="KVH98868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXQ6"/>
    <dbReference type="STRING" id="59895.A0A103XXQ6"/>
    <dbReference type="Gramene" id="KVH98868">
        <property type="protein sequence ID" value="KVH98868"/>
        <property type="gene ID" value="Ccrd_022903"/>
    </dbReference>
    <dbReference type="OMA" id="PMLAQER"/>
    <dbReference type="OrthoDB" id="1424968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000006">
        <property type="entry name" value="NAC domain-containing protein 100-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF219">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="39893" checksum="366536149E3A7B51" modified="2016-04-13" version="1">MMKDFPDEQMNLPPGFRFHPTDEELITHYLIHKVLDDTFSAKAIGEVDMNRIEPWELPRLAKMGEKEWYFFCVRDKKYPTGLRTNRATDAGYWKATGKDKEIIRGKSLVGMKKTLVFYKGRAPKGEKTNWVIHEYRLEGKPSIQTPPKTAKNEWVICRVFHKNSGEKKVNGSGMMLANSGGNELVPAPMPPLMDSSAPFAGGRATVIKSDSVNVPCFSNPITIQTPHNNFLNNPSYPFDPSSDGNNYCFPATQSSLPAMQDNPESQFQFQFQFGSGYTFPGQDQTILKGLIEDHHGFEMDGEMVTGSQETGLSSEMNTENSSVMSNLEIGKVGFQDQEAPSTSVAPIDDMDCIWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYH1</accession>
    <name>A0A103XYH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003630">
        <property type="protein sequence ID" value="KVH99227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYH1"/>
    <dbReference type="STRING" id="59895.A0A103XYH1"/>
    <dbReference type="Gramene" id="KVH99227">
        <property type="protein sequence ID" value="KVH99227"/>
        <property type="gene ID" value="Ccrd_022533"/>
    </dbReference>
    <dbReference type="OMA" id="HRTESKS"/>
    <dbReference type="OrthoDB" id="1667455at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000003">
        <property type="entry name" value="NAC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF212">
        <property type="entry name" value="PROTEIN SOMBRERO-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="362" mass="41332" checksum="F9CA8D3E9F451A71" modified="2016-04-13" version="1">MHEESFKLYFAEGAGRMMATGNGQVSVPPGFRFHPTDEELLYYYLWKKVSYEAIDLDVIREVDLNKLEPWDLKDKCRIGSGPQNEWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKAIHLLSNSKRIGMRKTLVFYTGRAPHGQKTDWIMHEYRLDDHYPNPSEVQEDGWVVCRVFKKKSHNRSPFQSDQHHTLQPADDHHQLTDQDNNKNGSLQLQALHNNSYDSSTSATTLFDSSMHLPQLLTSPDDHTPYFQGCTMMINDMDSSRNLLSLMSSASCRAGNCAGCSSGHQPQDKPLLATNNDWSFLDKLLASNQHHLGITSFDPSSSQPFHHPDVNPSSHVFPFHYLGYETDILKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ89</accession>
    <name>A0A103XZ89_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003431">
        <property type="protein sequence ID" value="KVH99619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ89"/>
    <dbReference type="STRING" id="59895.A0A103XZ89"/>
    <dbReference type="Gramene" id="KVH99619">
        <property type="protein sequence ID" value="KVH99619"/>
        <property type="gene ID" value="Ccrd_022147"/>
    </dbReference>
    <dbReference type="OMA" id="DTPNRGA"/>
    <dbReference type="OrthoDB" id="1435597at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000083">
        <property type="entry name" value="Transcription factor VIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690">
        <property type="entry name" value="TRANSCRIPTION FACTOR POSF21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690:SF127">
        <property type="entry name" value="VIRE2-INTERACTING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="341" mass="37882" checksum="5F91B7BDBA2E5301" modified="2016-04-13" version="1">MDPKFAGRPIAVASSYYGGGRMDIEQMPETPNRGARHRRAQSETFFRLPDEDILLDDVVADFNFANIDLPSLSSDAPIPTTTGDSSSKSEGESSDVNAAKSTASRPLSTSSHIRSLSVDADFFDGLGLNSAAESEKFSGGGYRHRHSNSMDGSAASSFEGDSMSMMLDNSKKALAPDKLAELALIDPKRAKRILANRQSAARSKERKIRYTGELERKVQTLQNEATTLSTQVTMLQRDTSGLTSENKELKLRLQAMEQQAKLRDALNETLRAEVQRLKIETGQMLPLNGMNYKRSLPSPQYSSHPQTFHHFGNQNTQQQQQQQQIRTPNNHQPKPTFMDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y014</accession>
    <name>A0A103Y014_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003402">
        <property type="protein sequence ID" value="KVI00024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y014"/>
    <dbReference type="STRING" id="59895.A0A103Y014"/>
    <dbReference type="Gramene" id="KVI00024">
        <property type="protein sequence ID" value="KVI00024"/>
        <property type="gene ID" value="Ccrd_021734"/>
    </dbReference>
    <dbReference type="OMA" id="LAFANQM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31529">
        <property type="entry name" value="LOB DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31529:SF4">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="25284" checksum="E1013861641C5D19" modified="2016-04-13" version="1">MADTHADGMSSDTRRKGPGVGKRTVASFEAATSETGSIPNPPCGACKFLRRKCVNGCIFAPYFGSDQGAARFAAVHKVFGASNVSKLLMHIPVNRRQHAVVTISYEAQARLSDPVAALQTELTMVQNQLINNRLLVANSLQSSQQQLEPVHHLSLLRPAYSNASSASNNNILNMNSFDSSLNNLADDHHRDTLSQQSFNPLQLCQPCNDDEDDDEEESGDPLAFANQMLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y096</accession>
    <name>A0A103Y096_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y096"/>
    <dbReference type="STRING" id="59895.A0A103Y096"/>
    <dbReference type="Gramene" id="KVI00162">
        <property type="protein sequence ID" value="KVI00162"/>
        <property type="gene ID" value="Ccrd_021623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033872">
        <property type="entry name" value="nsLTP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214:SF85">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_PLANT LIPID TRANSFER PROTEIN_SEED STORAGE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="20949" checksum="7D5C82D5AEA02EA9" modified="2016-04-13" version="1">MEKSPSYVGPRCFTVAVMVVMLLFTGHLQIIEAQQTRCNAVEVSWCLQAIVANMRPSRNCCQRLKGQENCLCRETHDPTFGGYLRLPGARRVANEFTVERETWVEVVRRRETGVEVRNRGVEEWSSTGEKETVTVVGDGGCRGNEDGEGGRFSSMCYSEKMIGVNSGSMETVGVTCVCCDCDQLGGCTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y233</accession>
    <name>A0A103Y233_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase/carboxylesterase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003131">
        <property type="protein sequence ID" value="KVI01099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y233"/>
    <dbReference type="STRING" id="59895.A0A103Y233"/>
    <dbReference type="Gramene" id="KVI01099">
        <property type="protein sequence ID" value="KVI01099"/>
        <property type="gene ID" value="Ccrd_020624"/>
    </dbReference>
    <dbReference type="OMA" id="VICEFKA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="17431" checksum="E568074FB04D08D0" modified="2016-04-13" version="1">MNPSKTSSFHLTSPTLVGLSHLLHLNLLPVTNSPVDESSLLKAVRNVHSMIDKELAAGTDPKNVFLCGFSQGVFSGWVPFNSTGSLTDQITPDAKRTPILWSHGTADVTVLFEAGQVGPAFLQRAGVICEFKAYPGLGHSINNQELQYLESWIKSHLQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2C0</accession>
    <name>A0A103Y2C0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plant specific Rop nucleotide exchanger, PRONE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003122">
        <property type="protein sequence ID" value="KVI01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2C0"/>
    <dbReference type="STRING" id="59895.A0A103Y2C0"/>
    <dbReference type="Gramene" id="KVI01250">
        <property type="protein sequence ID" value="KVI01250"/>
        <property type="gene ID" value="Ccrd_020469"/>
    </dbReference>
    <dbReference type="OMA" id="KDCANQV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000001">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1310:FF:000001">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2010">
        <property type="entry name" value="PRONE domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1310">
        <property type="entry name" value="PRONE domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005512">
        <property type="entry name" value="PRONE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038937">
        <property type="entry name" value="RopGEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101:SF57">
        <property type="entry name" value="PRONE DOMAIN, ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03759">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51334">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRONE" evidence="4">
        <location>
            <begin position="53"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="419" mass="47440" checksum="435691CE005031FA" modified="2016-04-13" version="1">MADEEQTLETHEEEEETMDVEQSTTDVEKSADVKQEDSSTSDSDKSTEQEKSETVKEKLKTDLEQMKEKFSKLLLGEDMSGGGKGVSSALALSNAITNLAASVFGEQRKLEPMPEDRKMRWRKEVRWLLSVTDHIVEFVPYQHTARDGSNMEDQKEFWYVSKDANESEKGVQRSDKWWLPTVKVPPGGLSEESRKWMQKQKDCANQVLKASMAINAEVLAEMEIPENYIDDLPKNGRDSLGDAIYKSITVEFFDPGQFLATIDLSSEHKILDLKNKMEASIVIWKRKMHQKESRSWGSSMKMEKRELFEERAETVLLLLKQRFPGLPQSSLDICKIESNKDVGHAVLESYSRVLESLANTVMNRIEDVLYADELAQNEANKSPTSDHTPGQTPRHTPTGTPTSTTISDFMGWGSDQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3D4</accession>
    <name>A0A103Y3D4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002684">
        <property type="protein sequence ID" value="KVI01781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3D4"/>
    <dbReference type="STRING" id="59895.A0A103Y3D4"/>
    <dbReference type="Gramene" id="KVI01781">
        <property type="protein sequence ID" value="KVI01781"/>
        <property type="gene ID" value="Ccrd_019955"/>
    </dbReference>
    <dbReference type="OMA" id="HNSKWRT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="5">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="5">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="214" mass="23635" checksum="0CFE450D20CB3FC2" modified="2016-04-13" version="1">MALSTPSTAITTPHHLPKLSHSHSHSHSVITFPAKLTTTTTTTTTTTNHHLISHNSKWRTSVSFFTGFLNKPKNVESIKQELLDAIAPLDRGAEASPEDQQSIEQIVRKLEAANPTKEPLKSPLLDGKWELLYTTSQSILQTKVTADLTPLNAKKVAVKFDYFKIAGLIPVKAPDTARGSLEITYLDEGLRVSRGDKGNLFILRMIDPSYRVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6B3</accession>
    <name>A0A103Y6B3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_018380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002369">
        <property type="protein sequence ID" value="KVI03325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6B3"/>
    <dbReference type="STRING" id="59895.A0A103Y6B3"/>
    <dbReference type="Gramene" id="KVI03325">
        <property type="protein sequence ID" value="KVI03325"/>
        <property type="gene ID" value="Ccrd_018380"/>
    </dbReference>
    <dbReference type="OMA" id="DISMPIP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000486">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000722">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF2">
        <property type="entry name" value="PROBABLY INACTIVE LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="537"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI03325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="779" mass="84436" checksum="284DB8AE4C103660" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y734</accession>
    <name>A0A103Y734_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y734"/>
    <dbReference type="STRING" id="59895.A0A103Y734"/>
    <dbReference type="Gramene" id="KVI03732">
        <property type="protein sequence ID" value="KVI03732"/>
        <property type="gene ID" value="Ccrd_017971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058921">
        <property type="entry name" value="PAP/OAS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979">
        <property type="entry name" value="PAP/OAS1 SUBSTRATE-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979:SF33">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="296" mass="32055" checksum="71AC7EE1BB728437" modified="2016-04-13" version="1">MPSSNIGDEIKKFFMNTLQRHKPKYGPDTALIYGSKGFGTLSISSLSEAYYEDDMYSRFSNGDFDDYLNDVSTVGSIEANNVPTFQSSSLRNGSDKFDSSPKSGQLGRSHSGRYDQNAPPSDSVDEKTGLELWMERGGSQLVDGDTICVCLNKNENENASDSLSSDVKERDATDSIGETEILNPFSDLTGDYDSHIRNLLYSQGCHGYALSAAMVCTSPPTSPYGNNNLWDAAALSWSVPFSSSQVNANGVPMGRPTYLNGGTNRTPTNAALRGTGPIGENSFHLKNEEEFPPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7V1</accession>
    <name>A0A103Y7V1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002305">
        <property type="protein sequence ID" value="KVI04131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7V1"/>
    <dbReference type="STRING" id="59895.A0A103Y7V1"/>
    <dbReference type="Gramene" id="KVI04131">
        <property type="protein sequence ID" value="KVI04131"/>
        <property type="gene ID" value="Ccrd_017552"/>
    </dbReference>
    <dbReference type="OMA" id="FRGQMRQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000009">
        <property type="entry name" value="probable transcription factor PosF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690:SF80">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690">
        <property type="entry name" value="TRANSCRIPTION FACTOR POSF21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="481"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="66817" checksum="BE9F55F636E9F604" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8S7</accession>
    <name>A0A103Y8S7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phosphoglycerate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001971">
        <property type="protein sequence ID" value="KVI04594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8S7"/>
    <dbReference type="STRING" id="59895.A0A103Y8S7"/>
    <dbReference type="Gramene" id="KVI04594">
        <property type="protein sequence ID" value="KVI04594"/>
        <property type="gene ID" value="Ccrd_017088"/>
    </dbReference>
    <dbReference type="OMA" id="IKRYKMM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF2">
        <property type="entry name" value="2-PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51846" checksum="86729DB3369F2BA1" modified="2016-04-13" version="1">MKKDKSVLIASPSGSTEAKSSSSNKVFFPEEEESEKQQTSNDFPLPAGTRNGSSKYDFVKVKVWLGDNADHYYVLSRFLLSRMLTVTKIPNHVALKIALELKKLLIDNSLLDVSQSDLEANLFKLMERRGYGQEYINRYKMMTRFHHQRVPLVILVCGTACVGKSTIATQLAQRLNLPNVLQTDMVYELLRTSTDAPLTSSPIWARDFNSSEELITEFCRECRIVRKGLAGDLKKAMKDGKPIIIEGMHVDPSIYLMDEENKSPHNVPVKAEQSNSSKMDEKDIKRMQNNASALRPHDENIPQSVENSKTEANVAEESDKISDRLKSVHLVDHTAASDKTKDEAADRNPILRREKSGVTEPVIIPIVLKMAEFDHKALLEEWISSRKFSDKYPIQEKDKLISNLKTIQDYLCSFKSQGLTVANISATTFPQTLDWLHNHLLQCIEQGMSSASKGSGGQTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9F9</accession>
    <name>A0A103Y9F9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_016750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001899">
        <property type="protein sequence ID" value="KVI04930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9F9"/>
    <dbReference type="STRING" id="59895.A0A103Y9F9"/>
    <dbReference type="Gramene" id="KVI04930">
        <property type="protein sequence ID" value="KVI04930"/>
        <property type="gene ID" value="Ccrd_016750"/>
    </dbReference>
    <dbReference type="OMA" id="XVYGSGS"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF7">
        <property type="entry name" value="UDP-GLUCURONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="13">
        <location>
            <begin position="70"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI04930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="380" mass="42674" checksum="68DB81E432ECCE19" modified="2016-04-13" version="1">MHVYIKVDQHLTILQTSSAFLPKLSDTVKCDPKKMATQGTTGANNATTRPPPNPSPLRTAKFFQANMRILVTGGAGFIGSHLVDRLMENEKNEVVVVDNYFTGSKDNLKQWIGHPRFELIRHDVTEPLLIEVDQIYHLACPASPIFYKHNPVKTIKTNVIGTLNMLGLAKRVGARILLTSTSEVYGDPLVHPQDESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNTYGPRMNIDDGRVVSNFIAQAIRNEPLTVQSPGTQTRSFCYVSDMVDGLVRLMEGNNTGPINIGNPGEFTMLELAENVKELINPEVKIIHVENTPDDPRQRKPVITKAKELLGWEPTVKLVDGLPRMEEDFRKRLGIPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAD7</accession>
    <name>A0A103YAD7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DELLA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_016234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The DELLA motif is required for its GA-induced degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GRAS family. DELLA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAD7"/>
    <dbReference type="STRING" id="59895.A0A103YAD7"/>
    <dbReference type="Gramene" id="KVI05456">
        <property type="protein sequence ID" value="KVI05456"/>
        <property type="gene ID" value="Ccrd_016234"/>
    </dbReference>
    <dbReference type="OMA" id="SQWRNRF"/>
    <dbReference type="OrthoDB" id="761920at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1290:FF:000001">
        <property type="entry name" value="DELLA protein GAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1290">
        <property type="entry name" value="Transcriptional regulator DELLA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038088">
        <property type="entry name" value="DELLA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021914">
        <property type="entry name" value="TF_DELLA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12041">
        <property type="entry name" value="DELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01129">
        <property type="entry name" value="DELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Transcriptional factor DELLA N-terminal" evidence="11">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="8">
        <location>
            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="8">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="8">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="8">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LXXLL motif" evidence="8">
        <location>
            <begin position="401"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="575" mass="62280" checksum="8C5E65ED850FBD37" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB40</accession>
    <name>A0A103YB40_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-specific protease family C19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB40"/>
    <dbReference type="STRING" id="59895.A0A103YB40"/>
    <dbReference type="Gramene" id="KVI05839">
        <property type="protein sequence ID" value="KVI05839"/>
        <property type="gene ID" value="Ccrd_015856"/>
    </dbReference>
    <dbReference type="OMA" id="NVCWGTR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040339">
        <property type="entry name" value="At1g16860-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33709:SF4">
        <property type="entry name" value="OS08G0230200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33709">
        <property type="entry name" value="OSJNBA0035M09.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="56325" checksum="62CCFD4FFFC28005" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBP7</accession>
    <name>A0A103YBP7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWEET sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001847">
        <property type="protein sequence ID" value="KVI06157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBP7"/>
    <dbReference type="STRING" id="59895.A0A103YBP7"/>
    <dbReference type="Gramene" id="KVI06157">
        <property type="protein sequence ID" value="KVI06157"/>
        <property type="gene ID" value="Ccrd_015510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="15048" checksum="5A7E1DEAC0E62468" modified="2016-04-13" version="1">MTRNLSHLTLAFGLLGNFVSVMRNADDVYKKKSTEGFQSASYVVGLFSAMLWIYCALLKSNVMPLITINIIETLYIDGEFEAICIANSCRVRIDCCPNSVPCKWSYLRGDSWMDLPCVSFKCFCSSFESFATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC69</accession>
    <name>A0A103YC69_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin-like family. Class-I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001832">
        <property type="protein sequence ID" value="KVI06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC69"/>
    <dbReference type="STRING" id="59895.A0A103YC69"/>
    <dbReference type="Gramene" id="KVI06381">
        <property type="protein sequence ID" value="KVI06381"/>
        <property type="gene ID" value="Ccrd_015294"/>
    </dbReference>
    <dbReference type="OMA" id="KVCVDIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027643">
        <property type="entry name" value="Formin-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213:SF273">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213">
        <property type="entry name" value="FORMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="126"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="592" mass="66402" checksum="058BFAF7E8718714" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD35</accession>
    <name>A0A103YD35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001555">
        <property type="protein sequence ID" value="KVI06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD35"/>
    <dbReference type="STRING" id="59895.A0A103YD35"/>
    <dbReference type="Gramene" id="KVI06882">
        <property type="protein sequence ID" value="KVI06882"/>
        <property type="gene ID" value="Ccrd_014762"/>
    </dbReference>
    <dbReference type="OMA" id="CLSWGCT"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000013">
        <property type="entry name" value="Aspartyl protease AED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000021">
        <property type="entry name" value="Aspartyl protease AED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF750">
        <property type="entry name" value="ASPARTYL PROTEASE AED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119612" evidence="8">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="136"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="479" mass="50812" checksum="25389787F14B3A5A" modified="2016-04-13" version="1">MGGASMKSLLMLLLSSSFFFSLVVARNQHALEEAIPNHYHNLQTTSFLPSSICTLSTKGDRKRGTLEVVHKHGPCSTFSKDMVKPLAVEDILSHDQDRVESIRSRLTITTDGKRDIRGSKATLPAKSGSTIGSGNYIVTVGLGTPKKDLSLIFDTGSDLTWTQCQPCARSCYAQQETIFAPSSSTTYSNISCSASECSGLTSATGNKPGCSASSSACIYGIQYGDQSFSVGFFAKDKLTLTSKDVINDFYFGCGQNNQGLFGGAAGLLGLGRDKLSIVSQSTREYGKVFSYCLPSRASYTGYLTFGKDRAASNAKYTPFSSSKGSSFYGLELQAIFVGGSKLAISPTVFSSSGMIIDSGTVITRLPPTAYSALSKAFRSQMTKYTLTKPLSILDTCYDFSKTTTVTIPVISMLWGGNIKVDIAAQGTLYANGIDQVCLAFAGNGDDSDIGIFGNVQQKTLGVVYDLPAGKVGFAPGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD74</accession>
    <name>A0A103YD74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate kinase</fullName>
            <ecNumber evidence="4">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001540">
        <property type="protein sequence ID" value="KVI06937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD74"/>
    <dbReference type="STRING" id="59895.A0A103YD74"/>
    <dbReference type="Gramene" id="KVI06937">
        <property type="protein sequence ID" value="KVI06937"/>
        <property type="gene ID" value="Ccrd_014724"/>
    </dbReference>
    <dbReference type="OMA" id="FFKNSNC"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="286" mass="31428" checksum="1135176E254D10B6" modified="2016-04-13" version="1">MAVLGRLLRPRTTTFYTIRTFCSSYSTSSPPSSSEIGVIEPLPAFGKITDGRNVQWVFLGCPGVGKGTYASRLSKLLCVPHIATGDLVRDELSSEGPLSSQLAEIVNQGKLVSDEIIINLLSQRLEAGEAKGESGFILDGFPRTIRQAEILEGVTNIDLVINLKLREEALLAKCLGRRTCSQCGGNYNVACIDIKADDGNPAMYMPPLLPPANCASKLITRSDDTEEVVKERLRVYNEKSRPVEEFYRRRGKLLEFDLPGGIPESWTKLLQLLNLDDHEDTRSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDD7</accession>
    <name>A0A103YDD7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_014611</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01001528">
        <property type="protein sequence ID" value="KVI07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDD7"/>
    <dbReference type="STRING" id="59895.A0A103YDD7"/>
    <dbReference type="Gramene" id="KVI07031">
        <property type="protein sequence ID" value="KVI07031"/>
        <property type="gene ID" value="Ccrd_014611"/>
    </dbReference>
    <dbReference type="OMA" id="QWPIAPH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF431">
        <property type="entry name" value="LACCASE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="84"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="338"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="53547" checksum="4DA9D4AA3818C6BA" modified="2016-04-13" version="1">MSYKIRRHGVRQVRTAWADGPEFITQCPIRPGGSYTYRFTISGQEGTLWWHAHSSWVRATVYGAIIIRPRKGESFPFAKPNRDSVILLGEWWDANPIDVIREATRTGAAPNVSDAYTINGQPGDLYNCSKKDTVIVPVSSGETNLIRVINAAMNQQLFFTIANHKFTVVGADASYVKPFSTDVLMLGPGQTTDVLIKGDQPPGRYYIAASAYASAQGAPFDNTTTTAILQYNGKNGIASKPIMPTLPAFNDTKTATAFTTSFRSQNKADVPTKIDENLFITASLGVNQCPPKAKPSNCQAPNGTRFTASMNNISFVLPTNFSLLQAHHQGIPGVFTADFPAKPPVTFDYTGNISTSLWQPISRTTVYKLKYGANVQIVLQGTGIFTAENHPIHLHGYDFYVIAEGFGNFNPKTDTAKFNLVDPAQRNTVSLPVNGWAVIRFVANNPGTWIMHCHLDIHIGWGLAMVFLVENGVGDLETLEQPPEDLPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF02</accession>
    <name>A0A103YF02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_013759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001474">
        <property type="protein sequence ID" value="KVI07879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF02"/>
    <dbReference type="STRING" id="59895.A0A103YF02"/>
    <dbReference type="Gramene" id="KVI07879">
        <property type="protein sequence ID" value="KVI07879"/>
        <property type="gene ID" value="Ccrd_013759"/>
    </dbReference>
    <dbReference type="OMA" id="RNACHDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 20, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="606"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI07879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="800" mass="91843" checksum="3142367B48AB6699" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFR8</accession>
    <name>A0A103YFR8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001149">
        <property type="protein sequence ID" value="KVI08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFR8"/>
    <dbReference type="STRING" id="59895.A0A103YFR8"/>
    <dbReference type="Gramene" id="KVI08285">
        <property type="protein sequence ID" value="KVI08285"/>
        <property type="gene ID" value="Ccrd_013349"/>
    </dbReference>
    <dbReference type="OMA" id="FCHDANT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF39">
        <property type="entry name" value="MAJOR FACILITATOR, SUGAR TRANSPORTER, MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="463" mass="49888" checksum="92492E41EE5358E1" modified="2016-04-13" version="1">MAIELVPGSSGRIDVGVDHKITYFSNKYVLGLTVIAGIGGLLFGYDTGALLYIRDEFEEVDQSSVLQETIVSMALLGAIFGAASGGWINDLYGRKSATLIADVIFVLGSFLMATAPDPYVLLFGRFLVGLGVGVASVTAPMYIAEVAPSEIRGGLVSTNVLMITSGQFLSYLVRGTWRWMLGIAAVPAILQFSLMLLLPESPRWLYKNEELHQLSAALEQECRSQNAVRYRDVFRIKEIRLAFVAGAGLQAFQQFIGINTVMYYSPTIVQMAGFGSNQLALQLSLIVALMNVAGTVVGIYLIDHVGRRKLALSSLIGVILSLVLLSIAFFLESSGHANIRWLAVLGLVLYIASFAPGMGPVPWTVNSEIYSESYRGMCGGMAATVNWVSNLIVSQSFLSVADAVGIGMTFLILAGVSVAAIGFVVMFVPETKGLTFEEVEKLWKERAWGSGNGAESLLEEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG67</accession>
    <name>A0A103YG67_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_013144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001114">
        <property type="protein sequence ID" value="KVI08482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG67"/>
    <dbReference type="STRING" id="59895.A0A103YG67"/>
    <dbReference type="Gramene" id="KVI08482">
        <property type="protein sequence ID" value="KVI08482"/>
        <property type="gene ID" value="Ccrd_013144"/>
    </dbReference>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.90:FF:000007">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000002">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000001">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="entry name" value="DNA gyrase/topoisomerase IV, subunit A, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="11">
        <location>
            <begin position="125"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI08482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="900" mass="99040" checksum="5E2B2517BF99C3AF" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGF8</accession>
    <name>A0A103YGF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001103">
        <property type="protein sequence ID" value="KVI08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGF8"/>
    <dbReference type="Gramene" id="KVI08605">
        <property type="protein sequence ID" value="KVI08605"/>
        <property type="gene ID" value="Ccrd_013022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14084" checksum="E4AA7E56FCE24A5F" modified="2016-04-13" version="1" fragment="single">MKQKAHVSPLISGGLDFDLVVSIGSETESNSHQRRCSWCSRRRWERNGGWGGDVKKKRHGGHGGWNSRERRCSETVMVFFAVVALRGFGFQLDVLILADSTSSVWFNFQLLNGQQQRQLLGIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGL1</accession>
    <name>A0A103YGL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001092">
        <property type="protein sequence ID" value="KVI08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGL1"/>
    <dbReference type="STRING" id="59895.A0A103YGL1"/>
    <dbReference type="Gramene" id="KVI08735">
        <property type="protein sequence ID" value="KVI08735"/>
        <property type="gene ID" value="Ccrd_012895"/>
    </dbReference>
    <dbReference type="OMA" id="NTMENGM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="130"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="377" mass="43146" checksum="39D2147C349BD53B" modified="2016-04-13" version="1">MKKVDPSHKLYRRMRLWEFPDRYIVQPIDGSSGSWLAVSRDDGSTTLVDEFAQCAKHFVPKFQPIFGVIGMLKLLAGSYLLVISERKTVGTYLGHHIFKVVSLKVLPCDQSSRNSSKQEKKMESEFSNLLKVTEKTPGLYFSYDVNITLSTQCLNELDDESKLLPLWRQLDPYMLPIIQGFQSTIGLDIIDVILIARRCTRKKGTRLWRRGADSDGYVANFVESEQIIQLKGCTSSFVQVRGSIPFLWEQRVGLTLKSKFKILRHEEAAQVAERHFLGLRKKYGNVLAIDLVSKHGDEGKLSEKFATSVQNIVSDDMRYNSIYFPVSYMINRLTCVDTCTSTSMAFVDMFILSAYLCFMQKLRIFCIKIGIFHLHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGR1</accession>
    <name>A0A103YGR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001089">
        <property type="protein sequence ID" value="KVI08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGR1"/>
    <dbReference type="STRING" id="59895.A0A103YGR1"/>
    <dbReference type="Gramene" id="KVI08786">
        <property type="protein sequence ID" value="KVI08786"/>
        <property type="gene ID" value="Ccrd_012830"/>
    </dbReference>
    <dbReference type="OMA" id="KPVATCF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016679">
        <property type="entry name" value="TF_GATA_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF138">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016992">
        <property type="entry name" value="TF_GATA_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="33555" checksum="65B5B0BC5EE12CE0" modified="2016-04-13" version="1">MDCLQSQSKPTFKFNHLPPSFSDDFLPLNADDFFVDGLLDFSTDAAFVQDDDNSQLLKHPDDTNNQKPSSVSPIKTDNHDRTTVPETELCLPVDDVADLEWVSQFVDDSFSGGYLLTCAEGKLPERKLETETVTLVAVNPSFKSMVYKKARSKRSRTGGRVWSLRSSTPLTDSSASSSSSSSCTSKPLLALEEILGKAPVKRQKKKKPAAMVETTGSGQPQPRRCSHCLVQKTPQWRAGPLGAKTLCNACGVRYKSGRLLPEYRPACSPTFSSEVHSNNHRKVLEMRRKKEEAVDGGVSLPVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGZ9</accession>
    <name>A0A103YGZ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYB transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_012695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGZ9"/>
    <dbReference type="STRING" id="59895.A0A103YGZ9"/>
    <dbReference type="Gramene" id="KVI08924">
        <property type="protein sequence ID" value="KVI08924"/>
        <property type="gene ID" value="Ccrd_012695"/>
    </dbReference>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000168">
        <property type="entry name" value="Telomere repeat-binding factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044597">
        <property type="entry name" value="SMH1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267">
        <property type="entry name" value="SINGLE MYB HISTONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267:SF11">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="13">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="293" mass="31985" checksum="DEE11519BE59D7A6" modified="2016-04-13" version="1">MGVPKQKWTLEEEAALKAGVAKYGPGKWSTILKDSEFVSVLHLRSNVDLKDKWRNLNLMASGYGSRQRARPGKSKTQSIHKLENISTASKEDHDMKVCIPDPSTTLAARLQIGSSNMSMPRLDSLILDTIANLKESHGSSRAAIAEYIEEKHSAPPNLEKLLKAELKALIGCGKLIKVKHRYRIAPSSSYLGLKENPSLLLLEVKQEYCSMEETGATKILTKADIDAELEKMRSMTPQQAAAVAVKAVAEAEAAISEAERAEREAQAAEADAELARVFAAAAMQSLKRTALCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH51</accession>
    <name>A0A103YH51_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001075">
        <property type="protein sequence ID" value="KVI09005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH51"/>
    <dbReference type="STRING" id="59895.A0A103YH51"/>
    <dbReference type="Gramene" id="KVI09005">
        <property type="protein sequence ID" value="KVI09005"/>
        <property type="gene ID" value="Ccrd_012626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12310" checksum="247FA75186BFB331" modified="2016-04-13" version="1">MGLEEKITEKTMIAADKVNRENEDEANLADKVELQRNLKISDEKLSAAIFLFVLMLVAHPFVLLRDKYQRNFHHFVAKIWASMTIVPFFRLKIQGSENLPPKDSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJK2</accession>
    <name>A0A103YJK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YJK2"/>
    <dbReference type="Gramene" id="KVI10254">
        <property type="protein sequence ID" value="KVI10254"/>
        <property type="gene ID" value="Ccrd_011363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11315" checksum="A863EAC32388D649" modified="2016-04-13" version="1">MVVPKDVRQNTPVKIGATAGLRQLGVDASERIMQAMREPIHRKKFEFXHYWNKSVDQIFGPAIEAVSSWREREHDDIDRSYEAGSNRFGFAIERLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLJ0</accession>
    <name>A0A103YLJ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000767">
        <property type="protein sequence ID" value="KVI11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLJ0"/>
    <dbReference type="Gramene" id="KVI11227">
        <property type="protein sequence ID" value="KVI11227"/>
        <property type="gene ID" value="Ccrd_010364"/>
    </dbReference>
    <dbReference type="OMA" id="TERYDIH"/>
    <dbReference type="OrthoDB" id="336008at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057221">
        <property type="entry name" value="DUF7899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789">
        <property type="entry name" value="OS05G0482600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789:SF10">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25463">
        <property type="entry name" value="DUF7899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55672" checksum="72836DD311AF97EC" modified="2016-04-13" version="1">MEGFGGSRNRRITMASSTGSGGNRRPPLCGGRRRVIATKKRGWTNPLAVNNSVKKLQRREICSKPHRSSSITKSLHRFCNFRLTERYDIHDPVGQCSLVLPLLMKRAKVIEIVVVHDIVFALASSGVCAAFSRDTNKRICFLNIYPDEVIRSLFYNKNNESLITVSVYASDNFSSLKCRSIRIEYIQRGKPDEGFPLFETESLKWPGFVEFDDVNEKVLTFSAQDSIYKVFDLKNYTLLYSIADQQVEEIKISPGIMLLIFSRGQSHVPLKILSIEDGTVLKDFNHLLHRNKKVDFIEQFNEKLLVKQDNENLQILDVRNAEVKEVASTEFMTPSAFIFLYENQLFLTFRNQTVSVWNFRGELVTSFEDHVLSHPDCNTNNIYITSDQDLIVSFCKADNGPLTDRRGAGSINISNIWTGKCIAKINASNAVSSKQDDDDDEDGRSPNQRQVEVNMVEEALEDITSLYYDEERNEIYTGNSNGLVHVWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLM3</accession>
    <name>A0A103YLM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GOLD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000447">
        <property type="protein sequence ID" value="KVI11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLM3"/>
    <dbReference type="STRING" id="59895.A0A103YLM3"/>
    <dbReference type="Gramene" id="KVI11290">
        <property type="protein sequence ID" value="KVI11290"/>
        <property type="gene ID" value="Ccrd_010301"/>
    </dbReference>
    <dbReference type="OMA" id="NDDHGPM"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47532">
        <property type="entry name" value="RETINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47532:SF1">
        <property type="entry name" value="RETINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="1">
        <location>
            <begin position="323"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="441" mass="50807" checksum="9B08CE8294DFC68F" modified="2016-04-13" version="1">MASTNGLVPITRAFLSSYYDKYPFPPIVSDVSRLSDELHNMSNELCKGSPFLPEGERLLLQEAESQPPHKMDENMWKNREQIEEIIFLLESSHWPKSLQQQSTPEDIELAQVLKQLKEKFEVALKLVESFQTKNSSNVFNTVMTYMPQDFRGTLIRQQRERSERNKQAEVDVLVNSGGNIRDRYALLWKQQMERRRQLSQLGSATGVYKTLVKYLVGVPQVLLDFIRQINDDHGPMEEQRQRYGPPLYALTKMVLNIHLFLSLSWWRFEDIKLQKHQMSILEEAVQVYVSELDRFLKFIGEVFANSPFFVTAEEAGAIEGIKTDGYSETTVTAGKTHEVSLMVESVNSYIAWDFSIMQGKISTDIGFCVEHTDSAGQKTLILPYRRYESDQGNFCTVMAGNYRLIWDNSYSTFFKKALRYKVDCIPPVVEPIPAAEAEKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLP2</accession>
    <name>A0A103YLP2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000326">
        <property type="protein sequence ID" value="KVI11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLP2"/>
    <dbReference type="STRING" id="59895.A0A103YLP2"/>
    <dbReference type="Gramene" id="KVI11348">
        <property type="protein sequence ID" value="KVI11348"/>
        <property type="gene ID" value="Ccrd_010249"/>
    </dbReference>
    <dbReference type="OMA" id="ICASAGW"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="27329" checksum="BD34FC8B94AAA600" modified="2016-04-13" version="1">MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSAIGILSKDGVVLVGEKKVTSKLLQTSTSTEKMYKIDDHVACAVAGIMSDANILINTARVQAQRYTLSYQEPMPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKNYGFQLYMSDPSGNYGGWKAAAVGANNQAAQSMLKQDYKEDITREEAVQLALKVLSKTMDSTSLTSDKLELAEVFLSSSGKVKYQVCTPDALSKMLIKYGVTQPPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMB0</accession>
    <name>A0A103YMB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zein-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_009850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000046">
        <property type="protein sequence ID" value="KVI11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMB0"/>
    <dbReference type="STRING" id="59895.A0A103YMB0"/>
    <dbReference type="Gramene" id="KVI11736">
        <property type="protein sequence ID" value="KVI11736"/>
        <property type="gene ID" value="Ccrd_009850"/>
    </dbReference>
    <dbReference type="OMA" id="MEACHYK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080115">
        <property type="term" value="F:myosin XI tail binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007656">
        <property type="entry name" value="GTD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31422">
        <property type="entry name" value="BNAANNG28530D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31422:SF1">
        <property type="entry name" value="GTD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04576">
        <property type="entry name" value="Zein-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51775">
        <property type="entry name" value="GTD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GTD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="545" mass="60747" checksum="E88010E1AEF3284D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN59</accession>
    <name>A0A103YN59_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RHOMBOID-like protein</fullName>
            <ecNumber evidence="9">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN59"/>
    <dbReference type="STRING" id="59895.A0A103YN59"/>
    <dbReference type="Gramene" id="KVI12164">
        <property type="protein sequence ID" value="KVI12164"/>
        <property type="gene ID" value="Ccrd_009400"/>
    </dbReference>
    <dbReference type="OMA" id="HFKKWVP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000019">
        <property type="entry name" value="RHOMBOID-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF79">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="132"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="46776" checksum="31B75885A53EA929" modified="2016-04-13" version="1">MAETLRPDIQIKVHSRRGLGVIHPVEVESSPTPLLRGTTAGNQSQTPSPYREIKHFKKWLPWLIPSFVIADTVLFIITMYVNDCPKNSVSCVATFLKRLSFQPFKENPLLGPSSSTLEKMGALDVERVVDGHQGWRLITCIWLHGGLLHLLANMLSLLVIGIRLEQEFGFIRIGLLYVISGFGGSLLSALFLQSNISVGASGAVFGLLGAMLSELITNWTIYANKVLLLNENVLFLLLDDEPECFSDSDYVVQLAALVTLVIIIVINLAVGILPHVDNFAHLGGFSSGFLLGFVFLMRPQFGWVSQRYTTPSVYSRSGTKPKYKTYQRVLWIVSLIVVVAGLIAGLVSLLRGVDLNDHCSWCHYMSCVPTSRWSCNTDPVTCVSEQTGNQFTLTCSNSNKNSTYLLTDPNSSQLRSLCSQLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN85</accession>
    <name>A0A103YN85_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN85"/>
    <dbReference type="STRING" id="59895.A0A103YN85"/>
    <dbReference type="Gramene" id="KVI12207">
        <property type="protein sequence ID" value="KVI12207"/>
        <property type="gene ID" value="Ccrd_009364"/>
    </dbReference>
    <dbReference type="OMA" id="KPENPYG"/>
    <dbReference type="OrthoDB" id="691484at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF96">
        <property type="entry name" value="PROTEIN OXIDATIVE STRESS 3 LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="28950" checksum="C966543129AB921E" modified="2016-04-13" version="1">MLRSSYPMSVAFETNSGGGGDRNRIQPPGFSHGMWIYNLSESGRFTGGSPWSSTLPVVKEEDSSSSSSIGKNSDALSGGGDSDEDDGEVQSKDNGSLNGLNSLEEVLPIRRGISTFYAGKSKSYGSLADASSVPSIQDIVKPEDAYSRKRKNMLAHNALLDKHRKSTTENGISKRLANSSSSCLDIGLNINGHDNKETGESSDSNSSHSGFSLPPLPSRQLPTDESSDSSRRLYCSPWRSLSLSDLQHVSAVTSSITGLVSNKRDNEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN89</accession>
    <name>A0A103YN89_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000011">
        <property type="protein sequence ID" value="KVI12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN89"/>
    <dbReference type="STRING" id="59895.A0A103YN89"/>
    <dbReference type="Gramene" id="KVI12157">
        <property type="protein sequence ID" value="KVI12157"/>
        <property type="gene ID" value="Ccrd_009429"/>
    </dbReference>
    <dbReference type="OMA" id="LMKCGAG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="217"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="313" mass="33529" checksum="3977BFD774C4CA51" modified="2016-04-13" version="1">MEAQVGVSSHGGVVDGSTAVKFLQKQQVVAPATASASSPRHHQQSAEIGTVPQLLAGGIAGAFSKTCTAPLARLTILFQVQGMHSEVALLSRPCIWNEASRIANEEGFRAFWKGNLVTIAHRLPYTAVNFYAYEQYKKLLKSIPSIGNNSESAAADACVHFVGGGMSGITAAMATYPLDLVRTRLAAQRSTIYYQGIGHALSTICREEGFFGLPNDSTVMVSLTCGSLSGIASSTATFPLDLVRRRKQLEGVGGRARVYNTGLVGTFGHIVRSEGFRGLYRGILPEFYKVVPGVGIVFMTYETLKKLLSEGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNT8</accession>
    <name>A0A103YNT8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNT8"/>
    <dbReference type="STRING" id="59895.A0A103YNT8"/>
    <dbReference type="Gramene" id="KVI12529">
        <property type="protein sequence ID" value="KVI12529"/>
        <property type="gene ID" value="Ccrd_009063"/>
    </dbReference>
    <dbReference type="OMA" id="MCDECEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37702">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37702:SF9">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119887" evidence="3">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="17108" checksum="B6D3216B5C12E6E8" modified="2016-04-13" version="1">MAEFSPFSFILTLLIIAGTTNFPPPATARIASYSRDEASCTMCDECENPCQLSPPLPSPPPPVPSDTKCPPPPSPPPSSGGNSPSFVPYYSPPPPPATPAGGYGYTTPPPPNPILPYFPFYYYNPPPPGQNSLSLQLQINCFHMVFPFYFLIFLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YP03</accession>
    <name>A0A103YP03_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_009116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YP03"/>
    <dbReference type="STRING" id="59895.A0A103YP03"/>
    <dbReference type="Gramene" id="KVI12520">
        <property type="protein sequence ID" value="KVI12520"/>
        <property type="gene ID" value="Ccrd_009116"/>
    </dbReference>
    <dbReference type="OMA" id="CHSINTL"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="10903" checksum="5582E51B0FD0C69B" modified="2016-04-13" version="1">MDRVKDLASKKAAVIFTKSTCCMCHSIKALFYELGASPAIHEVDHDAELEWALRRLGCNPEVPAVFVGGKYIGSAKDVISLHVDGSLKQKLIDARAIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSE0</accession>
    <name>A0A118JSE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPX2, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005354">
        <property type="protein sequence ID" value="KVH88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSE0"/>
    <dbReference type="STRING" id="59895.A0A118JSE0"/>
    <dbReference type="Gramene" id="KVH88662">
        <property type="protein sequence ID" value="KVH88662"/>
        <property type="gene ID" value="Ccrd_026186"/>
    </dbReference>
    <dbReference type="OMA" id="NGAGMVK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044806">
        <property type="entry name" value="WVD2/WDL1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46372:SF6">
        <property type="entry name" value="PROTEIN WVD2-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46372">
        <property type="entry name" value="PROTEIN WVD2-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="8">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="38993" checksum="486ED250254B45C3" modified="2016-04-13" version="1">MGRDIASLRIDKKPNVGNVNSNGVIRGTNHASPKHSGESVKVRKSEAEDGTIEGSHVERSPEKQHAVAVKSTNHETGSPEGITQKPEPSKSREKIISSPVSAASGSASVEENIAPGLHASSNISNFHSPTNTKQSQRNYPFSTPRPQKSDTNKYRDEEDNWSLASSYPFLISMYSAATSVRTVKSRVTVGVAPSFRSAQRAAQRKEFYTKLEQKHQALKAEKMEYEARTKEEQEEAIKQLRKSMVVKANPVPSFYRQGPPPKAELKKLPLTRAKSPKLSRRKSCGDTTHSSVDEKALCSRVRHSLGAYKPGSVASSPIKQNINGINKAKDRTTNETPKASPHKLTNETKDITVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTH4</accession>
    <name>A0A118JTH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007216</name>
        <name evidence="10" type="ORF">Ccrd_012269</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005094">
        <property type="protein sequence ID" value="KVH90774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTH4"/>
    <dbReference type="SMR" id="A0A118JTH4"/>
    <dbReference type="STRING" id="59895.A0A118JTH4"/>
    <dbReference type="Gramene" id="KVH90774">
        <property type="protein sequence ID" value="KVH90774"/>
        <property type="gene ID" value="Ccrd_007216"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI09357">
        <property type="protein sequence ID" value="KVI09357"/>
        <property type="gene ID" value="Ccrd_012269"/>
    </dbReference>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="10250051at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="17819" checksum="4F61C0B44E095037" modified="2016-04-13" version="1">MPPKFDPSQVVDVYVRVTGGEVGAASSLAPKIGPLGLSPKKIGEDIAKETAKDWKGLRVTVKLTVQNRQAKVSVVPSAAALVIKALKEPERDRKKVKNIKHSGNISLDDVIEIAKVMRPRSMAKELQGTVKEILGTCVSVGCTVDGKDPKDLQQEIADGDVEIPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU22</accession>
    <name>A0A118JU22_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_007446</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU22"/>
    <dbReference type="STRING" id="59895.A0A118JU22"/>
    <dbReference type="Gramene" id="KVH90537">
        <property type="protein sequence ID" value="KVH90537"/>
        <property type="gene ID" value="Ccrd_007446"/>
    </dbReference>
    <dbReference type="OMA" id="RTIMQIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF84">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159677" description="non-specific serine/threonine protein kinase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="431"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH90537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="714" mass="78719" checksum="FA7EA061D63EF777" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUF6</accession>
    <name>A0A118JUF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">POX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005011">
        <property type="protein sequence ID" value="KVH91419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUF6"/>
    <dbReference type="STRING" id="59895.A0A118JUF6"/>
    <dbReference type="Gramene" id="KVH91419">
        <property type="protein sequence ID" value="KVH91419"/>
        <property type="gene ID" value="Ccrd_006559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37251" checksum="38E09D96580E7E60" modified="2016-04-13" version="1">MENNGMSMALGILDESFPTFLDQTHNFPINHTDLTQHFQPDFPSVVNTDEAPSYDAYEHFGFDRMIADYVNTKWDHSNQFFEPPKEHSGFHTQMDSWVSSENNSSLSSDSNGWPSLNLDTDSRISGLLLMDNSKQDHFCNSKSMSSSRSDFDDDRQIQLLSQSHQSGSKRYLTMIQEILSEITTCFLGDVEKTSHKQMDLNDRFEGHNHPELRGLGVKAIRKHLLVLLQQLDPRMHASFALQTISLFRNNLRKRLRNRILAVGPDLNEIDPKESELSSLLRKHWAHQRLRGKGQQLWKPQRGLPEKSVSVLREWIFQNFLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVC3</accession>
    <name>A0A118JVC3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVC3"/>
    <dbReference type="STRING" id="59895.A0A118JVC3"/>
    <dbReference type="Gramene" id="KVH92859">
        <property type="protein sequence ID" value="KVH92859"/>
        <property type="gene ID" value="Ccrd_005077"/>
    </dbReference>
    <dbReference type="OMA" id="IMAASAW"/>
    <dbReference type="OrthoDB" id="1936481at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="409"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="616"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LxCxE motif" evidence="3">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="440"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="692" mass="77428" checksum="C581AD5F20220CBC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVX7</accession>
    <name>A0A118JVX7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004770">
        <property type="protein sequence ID" value="KVH93417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVX7"/>
    <dbReference type="Gramene" id="KVH93417">
        <property type="protein sequence ID" value="KVH93417"/>
        <property type="gene ID" value="Ccrd_004533"/>
    </dbReference>
    <dbReference type="OMA" id="IVATIMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF7">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="8">
        <location>
            <begin position="63"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="39805" checksum="1C54B143E03F9064" modified="2016-04-13" version="1">METLTLKDIANITIPVEQVIDILVESYKSSEIYMEVQSEVASICGQEGDLIEKKRSLRASSITQCMVLAKRSFINMYRDVGYYWLRLGIYIALGFALGTVFYNIGSGFGSLNARLSLLMFVSSFLTILAIGGFPSFVEEMKVFQWERLNGHYRIGSFVISHAISSAPYLLLISLIPGVIAYSLAGLQREYERFIYFSLILFASMLLVECLMMIVATIMPNLLMGIISSAGIQGLMILSAGFFRLPNDLPHIFWRYPMYYISFHRYALQGLYKNEFEGLEFPEYVGGPPTIDGKMILKGVLQIETGYSKWIDLGILFGMVFVYRVLLFCTIKTTERVKPIVRAFLLTSTFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWI5</accession>
    <name>A0A118JWI5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004534">
        <property type="protein sequence ID" value="KVH94687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWI5"/>
    <dbReference type="STRING" id="59895.A0A118JWI5"/>
    <dbReference type="Gramene" id="KVH94687">
        <property type="protein sequence ID" value="KVH94687"/>
        <property type="gene ID" value="Ccrd_003245"/>
    </dbReference>
    <dbReference type="OMA" id="ICKEPAT"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000192">
        <property type="entry name" value="Homeobox-leucine zipper protein HAT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050762">
        <property type="entry name" value="HD-ZIP_Homeobox_LZ_Class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714:SF39">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00340">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="214"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="39519" checksum="DCDDA12201D00577" modified="2016-04-13" version="1">MELGLSLGDTPKPVSFADRSISQLQKTKDSGFYMGLNSSSTIQDPHHKNFRENDDDDKTNCSSSSSDRPLVQLDLLPFSPALDQSPPPPPSHRPFPWLSQILIADTGHRTKLGKGLDVKPLTAIYDPDICKEPATVQSSPDNSNSDTSSFQMDFSSIFKSSTGSSRLPSKQRDLELTKGSFDYLVEASERDQRVLSSRGGGGGGYGGTSDEEENGLGRKKLRLTKQQSAFLEDSFKEHNTLNPKQKLVLANQLNLRPRQVEVWFQNRRARTKLKQTEVDCEYLKTCCETLTEENRRLQKELQELRALKTSQPFYMQLPATTLTMCPSCERVVTTTPATTTTTTLPQEPAANNGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWZ0</accession>
    <name>A0A118JWZ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004382">
        <property type="protein sequence ID" value="KVH95546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWZ0"/>
    <dbReference type="STRING" id="59895.A0A118JWZ0"/>
    <dbReference type="Gramene" id="KVH95546">
        <property type="protein sequence ID" value="KVH95546"/>
        <property type="gene ID" value="Ccrd_002380"/>
    </dbReference>
    <dbReference type="OMA" id="WYEELPK"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31861:SF15">
        <property type="entry name" value="DUF577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31861">
        <property type="entry name" value="OS10G0507500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="238" mass="27279" checksum="CD49577C7A83D91C" modified="2016-04-13" version="1">MGGHGGLNILPQKRWNVYNFDNREKVRKDEEAAAKEEQLKREQSRKRDTEFRLEQLRQARGLASASASASASSSRQSTAVAVESPPAPVPEPQPEVEPKSRHINLFEGIRIFDPVEIVDKNKSEPGDEQRKGYKRIKKEAEMPKVVLPEDEKYRLGYGVAGKGVKLPWYMEKRPNGDDKGVDDCDSVTVTKSSRKKSVEELREERLKREGKEKERERALLLHKGRRGSLIQNDRYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX09</accession>
    <name>A0A118JX09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L37ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002690</name>
        <name evidence="8" type="ORF">Ccrd_008254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005145">
        <property type="protein sequence ID" value="KVH89752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX09"/>
    <dbReference type="SMR" id="A0A118JX09"/>
    <dbReference type="STRING" id="59895.A0A118JX09"/>
    <dbReference type="Gramene" id="KVH89752">
        <property type="protein sequence ID" value="KVH89752"/>
        <property type="gene ID" value="Ccrd_008254"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH95262">
        <property type="protein sequence ID" value="KVH95262"/>
        <property type="gene ID" value="Ccrd_002690"/>
    </dbReference>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="1844229at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48149">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48149:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="10257" checksum="C8B13AF26FE238B2" modified="2016-04-13" version="1">MTKRTKKAGIVGKYGTRYGASLRKQIKKMEVSQHSKYFCEFCGKYAVKRKAVGIWGCKDCGKVKAGGAYTLNTASAVTVRSTIRRLREQTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXK7</accession>
    <name>A0A118JXK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004335">
        <property type="protein sequence ID" value="KVH96297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXK7"/>
    <dbReference type="Gramene" id="KVH96297">
        <property type="protein sequence ID" value="KVH96297"/>
        <property type="gene ID" value="Ccrd_001614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="94" mass="10846" checksum="E4478FDD343B8B00" modified="2016-04-13" version="1" fragment="single">CPWRWPSVPCNQPRFRRRWTPWRPRIACQQGIVAKLPSLETKHPQLVVRIAANYISPSTVDPSTAPNGSRMKLVISHVTVYSRPYIIDQPLMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXR3</accession>
    <name>A0A118JXR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004178">
        <property type="protein sequence ID" value="KVH96806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXR3"/>
    <dbReference type="STRING" id="59895.A0A118JXR3"/>
    <dbReference type="Gramene" id="KVH96806">
        <property type="protein sequence ID" value="KVH96806"/>
        <property type="gene ID" value="Ccrd_001103"/>
    </dbReference>
    <dbReference type="OMA" id="LDYHVNE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF9">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159791" evidence="8">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="10956" checksum="1AB4A5C10F6F538C" modified="2016-04-13" version="1" fragment="single">MARDLSPVFSVLIILGFILVRTLVVAGQPQVPCYFIFGDSLVDSGNNNGLNTTARANYPPYGIDFVPGVTGRFTNGRTIADVLMISSLHSPKHMVQPVHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYC4</accession>
    <name>A0A118JYC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_023392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003800">
        <property type="protein sequence ID" value="KVH98392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYC4"/>
    <dbReference type="STRING" id="59895.A0A118JYC4"/>
    <dbReference type="Gramene" id="KVH98392">
        <property type="protein sequence ID" value="KVH98392"/>
        <property type="gene ID" value="Ccrd_023392"/>
    </dbReference>
    <dbReference type="OMA" id="MSKWDAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000029">
        <property type="entry name" value="Cytochrome P450 734A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH98392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="960" mass="110923" checksum="1C1F9F421DE7F3DA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYK4</accession>
    <name>A0A118JYK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_023878</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with 1-naphthylphthalamic acid (NPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH97917">
        <property type="protein sequence ID" value="KVH97917"/>
        <property type="gene ID" value="Ccrd_023878"/>
    </dbReference>
    <dbReference type="OMA" id="RANVMHQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1183"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="322"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="644"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="960"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH97917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1525" mass="167933" checksum="E1110504929372B5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYY7</accession>
    <name>A0A118JYY7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003786">
        <property type="protein sequence ID" value="KVH98592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYY7"/>
    <dbReference type="STRING" id="59895.A0A118JYY7"/>
    <dbReference type="Gramene" id="KVH98592">
        <property type="protein sequence ID" value="KVH98592"/>
        <property type="gene ID" value="Ccrd_023185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368:SF19">
        <property type="entry name" value="GFO_IDH_MOCA-LIKE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="476"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="685" mass="75870" checksum="BC6A89148D49FB28" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ33</accession>
    <name>A0A118JZ33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_023754</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ33"/>
    <dbReference type="STRING" id="59895.A0A118JZ33"/>
    <dbReference type="Gramene" id="KVH98020">
        <property type="protein sequence ID" value="KVH98020"/>
        <property type="gene ID" value="Ccrd_023754"/>
    </dbReference>
    <dbReference type="OMA" id="CHNQYIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF75">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="12">
        <location>
            <begin position="331"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH98020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="574" mass="66801" checksum="A42CD2018F768DEE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1W0</accession>
    <name>A0A118K1W0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Achaete-scute transcription factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002351">
        <property type="protein sequence ID" value="KVI03452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1W0"/>
    <dbReference type="STRING" id="59895.A0A118K1W0"/>
    <dbReference type="Gramene" id="KVI03452">
        <property type="protein sequence ID" value="KVI03452"/>
        <property type="gene ID" value="Ccrd_018248"/>
    </dbReference>
    <dbReference type="OMA" id="HNIYTSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000074">
        <property type="entry name" value="Transcription factor ORG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF41">
        <property type="entry name" value="TRANSCRIPTION FACTOR ORG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="222" mass="24965" checksum="CE107274F2C968AE" modified="2016-04-13" version="1">MMLVSPPLFSTTYGWPLEDLITPNLQQDCNEANSYHSLLDIPSFDQIQQDFAPEKSNSSGGAVNGDTVDNMTVGKKLNHNASERDRRKRVNDLYAFLRSLLPMSTAQKKKVSIPGTVSHALKYIAELQKEVERLIRKKEQLSSCFSPIHITGVEHLDIRNQKSANDATIQTSSTVVSSVSFIDEKEAVIQLISLIDRMNKNKEIGFLSKTMEYLEQEEDGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1X7</accession>
    <name>A0A118K1X7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">lycopene beta-cyclase</fullName>
            <ecNumber evidence="4">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carotenoid biosynthesis; beta-zeacarotene biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lycopene cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002349">
        <property type="protein sequence ID" value="KVI03465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1X7"/>
    <dbReference type="STRING" id="59895.A0A118K1X7"/>
    <dbReference type="Gramene" id="KVI03465">
        <property type="protein sequence ID" value="KVI03465"/>
        <property type="gene ID" value="Ccrd_018234"/>
    </dbReference>
    <dbReference type="OMA" id="FVLMDFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000101">
        <property type="entry name" value="lycopene epsilon cyclase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010108">
        <property type="entry name" value="Lycopene_cyclase_b/e"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01790">
        <property type="entry name" value="carotene-cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39757">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39757:SF5">
        <property type="entry name" value="OS02G0190600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05834">
        <property type="entry name" value="Lycopene_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="533" mass="59982" checksum="0214C339A08C2024" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3A6</accession>
    <name>A0A118K3A6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3A6"/>
    <dbReference type="STRING" id="59895.A0A118K3A6"/>
    <dbReference type="Gramene" id="KVI05625">
        <property type="protein sequence ID" value="KVI05625"/>
        <property type="gene ID" value="Ccrd_016030"/>
    </dbReference>
    <dbReference type="OMA" id="ACFDKFL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049172">
        <property type="entry name" value="DUF6857_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048297">
        <property type="entry name" value="DUF936_dom_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010341">
        <property type="entry name" value="DUF936_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928:SF6">
        <property type="entry name" value="DUF936 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21647">
        <property type="entry name" value="DUF6857"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06075">
        <property type="entry name" value="DUF936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF936" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="321"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="571" mass="62738" checksum="C44E051E8B58729F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3D5</accession>
    <name>A0A118K3D5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Late embryogenesis abundant protein, LEA-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3D5"/>
    <dbReference type="STRING" id="59895.A0A118K3D5"/>
    <dbReference type="Gramene" id="KVI05806">
        <property type="protein sequence ID" value="KVI05806"/>
        <property type="gene ID" value="Ccrd_015819"/>
    </dbReference>
    <dbReference type="OMA" id="RIDILFQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF71">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN, LEA_2 SUBGROUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="20992" checksum="FE81D973F149366B" modified="2016-04-13" version="1" fragment="single">MDGPALSFQFSYKKCFWFLLLIIGLFILISVFFSLIIIFVLKPRRPIFSFQTVNIASYKFDVSESSTLFLSLVASVTLIAENPNRIGLKYDFSRLQILKDGLVIGLIRTPEFYQPARSHNVSVEMNLVFQCLDITTIMSGVDTANFSIKVLGDIGVRLRVLQIKLPKMKAHFDANSQALWKKCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3U5</accession>
    <name>A0A118K3U5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3U5"/>
    <dbReference type="STRING" id="59895.A0A118K3U5"/>
    <dbReference type="Gramene" id="KVI06478">
        <property type="protein sequence ID" value="KVI06478"/>
        <property type="gene ID" value="Ccrd_015182"/>
    </dbReference>
    <dbReference type="OMA" id="KHESRCP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177">
        <property type="entry name" value="F18C1.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177:SF4">
        <property type="entry name" value="OS06G0283200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="596" mass="66673" checksum="2F0515B03889D4B6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4D1</accession>
    <name>A0A118K4D1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the plant dehydrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4D1"/>
    <dbReference type="STRING" id="59895.A0A118K4D1"/>
    <dbReference type="Gramene" id="KVI07383">
        <property type="protein sequence ID" value="KVI07383"/>
        <property type="gene ID" value="Ccrd_014315"/>
    </dbReference>
    <dbReference type="OMA" id="DENDKCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009631">
        <property type="term" value="P:cold acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000167">
        <property type="entry name" value="Dehydrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030513">
        <property type="entry name" value="Dehydrin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33346:SF2">
        <property type="entry name" value="DEHYDRIN ERD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33346">
        <property type="entry name" value="DEHYDRIN XERO 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00257">
        <property type="entry name" value="Dehydrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00823">
        <property type="entry name" value="DEHYDRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="36498" checksum="CCFE69991071805C" modified="2016-04-13" version="1" fragment="single">EHTISFRHPQNFPFQTKSPTFSHSYCVCVFFNPFAVIMADEVVYHHAPKTEDHCESTNVVKTENEDVEKSDRGLFDYFGKKDENDKCAEAEIASDCKDENKEEKSESLLEKLHISDGSSSSSSSEDECEDGEKKKKKKKKDKNLKEKAEKKLEEEKVKIAVKIEEGKEKVEEIKEKIHEKIEEHKEKKIEEHKDDDTCVVPVEKYEEAAVVPPSSHHHESPPAPPCEVVVHPPEPSCEPEEKKGFIEKIKEKLPGGHKKAEDDYAAPPPPPPVTAVPAEHYVDAESEHKEKKGILEKIKEKLPGYHSKSHEEEKKEKECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5A5</accession>
    <name>A0A118K5A5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001089">
        <property type="protein sequence ID" value="KVI08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5A5"/>
    <dbReference type="STRING" id="59895.A0A118K5A5"/>
    <dbReference type="Gramene" id="KVI08805">
        <property type="protein sequence ID" value="KVI08805"/>
        <property type="gene ID" value="Ccrd_012814"/>
    </dbReference>
    <dbReference type="OMA" id="DSYLPFM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="225"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="492" mass="56854" checksum="4BBF0E2AE8098E79" modified="2016-04-13" version="1">MVVRSVARDYLPPEFRDYLYLGFRNFINKFSIYLTMVIYEFNGFRDNEIYNATELYVAARMSTDFHRLKVIKNPTQKNITVTMEVNEDFTDTFNGAKFYWSSVSKKTPTRQYDGHDSRTSRTDLRWLELTFHRDHKDLVLNEYLPFILNEAEMKKKEQKTVKLFTVKTNSSYSKMGTAKWKSVNLDHPASFATLAMDADMKEMVKKDLDRFVARREYYRKVGKAWKRGYLLHGPPGTGKSSLIAAIVNYLNFDIYDLELTDIKSNSELRSLLVATANRSILVVEDIDCSVELHDRVAVEAAKAVTLSGFLNFVDGLWSSCGDERIIIFTTNRKNKLDPALIRPGRMDLHIHMSYCTPCGFRLLASNYLGITQHDLFNQIEDLMSEVNVTPAEVAEQLLKDDDPSVVLDGLIKFIDVKRKMNEEAKAKRKEKKEAKRKMNEEAEAKRNEKEKEEAEAEAEAETEVETARKEKEEAKIKVTKKEKEKAKLDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K623</accession>
    <name>A0A118K623_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K623"/>
    <dbReference type="STRING" id="59895.A0A118K623"/>
    <dbReference type="Gramene" id="KVI10022">
        <property type="protein sequence ID" value="KVI10022"/>
        <property type="gene ID" value="Ccrd_011602"/>
    </dbReference>
    <dbReference type="OMA" id="GWWHERD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF141">
        <property type="entry name" value="POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="329"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="435"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="575"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="698" mass="78750" checksum="38DE962D4D951D16" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6A9</accession>
    <name>A0A118K6A9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6A9"/>
    <dbReference type="STRING" id="59895.A0A118K6A9"/>
    <dbReference type="Gramene" id="KVI10395">
        <property type="protein sequence ID" value="KVI10395"/>
        <property type="gene ID" value="Ccrd_011191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="Photosystem II antenna protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="14151" checksum="D6898A5819237D96" modified="2016-04-13" version="1">MALYELAVFNPSDPVLDPMWRLGLTKLPPSGRPYAAPTKGSLAAMLSREIKRLEKKKTTILKSPGRTKQHLKANGQQNVPSQLTKTFSKVQQITMGKGEKVFSKIGTSATEDLSEDPNSPQTKHWCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAL6</accession>
    <name>A0A124SAL6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin/actin-like conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005753">
        <property type="protein sequence ID" value="KVH87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAL6"/>
    <dbReference type="STRING" id="59895.A0A124SAL6"/>
    <dbReference type="Gramene" id="KVH87867">
        <property type="protein sequence ID" value="KVH87867"/>
        <property type="gene ID" value="Ccrd_024819"/>
    </dbReference>
    <dbReference type="OMA" id="KWIAKTE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048767">
        <property type="term" value="P:root hair elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="438" mass="48472" checksum="90ACCE452B354D46" modified="2016-04-13" version="1">MPKACQRQVTLSFLVVRMIPPSPPFTPHFQIYTPSSASPNILLDYTSEPRVSFAGHSSSIKMADSEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDSLMKILTERGYMFTTTAEREIVRDMKEKLAYVALDYEQELETAKSSSSVEKNYELPDGQVITIGAERFRCPEVLFQPSLIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKGEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAM5</accession>
    <name>A0A124SAM5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-actin capping protein, alpha subunit, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005674">
        <property type="protein sequence ID" value="KVH87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAM5"/>
    <dbReference type="STRING" id="59895.A0A124SAM5"/>
    <dbReference type="Gramene" id="KVH87956">
        <property type="protein sequence ID" value="KVH87956"/>
        <property type="gene ID" value="Ccrd_024663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0117">Actin capping</keyword>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="20078" checksum="DA30DB983BC1504A" modified="2016-04-13" version="1" fragment="single">VLVSSFSEISEDEYLDPRTAQVGKVDHVSHSHSHTYLDPRTAQVGKVDHVKQPVLLSPPPTNPPEFPISFSTSPNPIQYMAKGRLQRPFLFTTKRTSFLSSSLIEVICTEIRPARDEELPTPYIEDYRCALDAEVSKYVAESYPKGVCSVYCTSGKDVEEPGFDFELVQWKLALNMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAX8</accession>
    <name>A0A124SAX8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005326">
        <property type="protein sequence ID" value="KVH88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAX8"/>
    <dbReference type="STRING" id="59895.A0A124SAX8"/>
    <dbReference type="Gramene" id="KVH88900">
        <property type="protein sequence ID" value="KVH88900"/>
        <property type="gene ID" value="Ccrd_024721"/>
    </dbReference>
    <dbReference type="OMA" id="LESPPCI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14361" checksum="342EAC146D5CEBE4" modified="2016-04-13" version="1" fragment="single">MATATYPPPPPYYRLYKDYEQNPSSAPEPPPPIEGTYLLYGANYTTDDVLPTLEDQGVRQLYPKGSNVDFKKELRSLNRELQLHILELADVLIERPSQYARRVEDISLIFKNLHHLLNSLRPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBV1</accession>
    <name>A0A124SBV1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoglucanase</fullName>
            <ecNumber evidence="11">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_006162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBV1"/>
    <dbReference type="STRING" id="59895.A0A124SBV1"/>
    <dbReference type="Gramene" id="KVH91792">
        <property type="protein sequence ID" value="KVH91792"/>
        <property type="gene ID" value="Ccrd_006162"/>
    </dbReference>
    <dbReference type="OMA" id="GNQRIAW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019028">
        <property type="entry name" value="CBM_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09478">
        <property type="entry name" value="CBM49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01063">
        <property type="entry name" value="CBM49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990597" description="Endoglucanase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding" evidence="12">
        <location>
            <begin position="503"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="596" mass="65066" checksum="4C067716C120E26D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC15</accession>
    <name>A0A124SC15_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="10">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of serine and glycine.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004820">
        <property type="protein sequence ID" value="KVH92380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC15"/>
    <dbReference type="STRING" id="59895.A0A124SC15"/>
    <dbReference type="Gramene" id="KVH92380">
        <property type="protein sequence ID" value="KVH92380"/>
        <property type="gene ID" value="Ccrd_005567"/>
    </dbReference>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="11">
        <location>
            <begin position="93"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="479" mass="52777" checksum="A8A2FF96F1FEFE8A" modified="2016-04-13" version="1">MAMALALRRLSSSADKPLQRLLNGGHLYSMSSLPSEAVYEKENPGVTWPKQLNAPLEVVDPEIADIIELEKARQWKVVSLFLLLCFTLLLWRQLRRQTNLGLELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPSNFQVYTALLKAHDRIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDESTGLIDYDQLEKSATLFRPKLIVAGASAYARLYDYARIRKVCDKQKAILLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEVTKQGKEVFYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQTLMESGYELVSGGTENHLVLVNLKPKGIDGSRVEKVLEAVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFAKVAYFFDHAVKLALKIKGEAQVSSLIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD67</accession>
    <name>A0A124SD67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004365">
        <property type="protein sequence ID" value="KVH96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD67"/>
    <dbReference type="STRING" id="59895.A0A124SD67"/>
    <dbReference type="Gramene" id="KVH96011">
        <property type="protein sequence ID" value="KVH96011"/>
        <property type="gene ID" value="Ccrd_001915"/>
    </dbReference>
    <dbReference type="OMA" id="TRCHSNI"/>
    <dbReference type="OrthoDB" id="625231at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="94" mass="10769" checksum="C5E3A24E31723E0A" modified="2016-04-13" version="1">MGVFRVHSLVANLKQMIKLHNKHQSDVPKGHLAVYVGEIQKKRFVVPLSYLDQPLFQDLLRRSEEEYGFNHPMGGLTIPCHEEAFVNLTAQLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDE9</accession>
    <name>A0A124SDE9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004237">
        <property type="protein sequence ID" value="KVH96730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDE9"/>
    <dbReference type="Gramene" id="KVH96730">
        <property type="protein sequence ID" value="KVH96730"/>
        <property type="gene ID" value="Ccrd_001179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="57" mass="6534" checksum="1A3036EB4A8AD55E" modified="2016-04-13" version="1">MQTYCSSLTGDKNGTMANFTKVAYISHDLRYFQIQSMGATTLDEYLKHIKKDLALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE45</accession>
    <name>A0A124SE45_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE45"/>
    <dbReference type="STRING" id="59895.A0A124SE45"/>
    <dbReference type="Gramene" id="KVH98937">
        <property type="protein sequence ID" value="KVH98937"/>
        <property type="gene ID" value="Ccrd_022845"/>
    </dbReference>
    <dbReference type="OMA" id="MGLQANP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052657">
        <property type="entry name" value="PDP_family_Arabidopsis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10688">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10688:SF6">
        <property type="entry name" value="SERINE_THREONINE-KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112365" checksum="EFA7202E87BF9CF4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE60</accession>
    <name>A0A124SE60_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE60"/>
    <dbReference type="Gramene" id="KVH99082">
        <property type="protein sequence ID" value="KVH99082"/>
        <property type="gene ID" value="Ccrd_022673"/>
    </dbReference>
    <dbReference type="OMA" id="RSSFEQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044520">
        <property type="entry name" value="ARF_GAP_AGD5/15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419:SF10">
        <property type="entry name" value="ARF GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="459" mass="49595" checksum="A5182244920B5A54" modified="2016-04-13" version="1">MNEKANVSKELNARHRKILEGLLKLPENRECADCKAKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQCKLNFLNFRHFSFAFIVYSAMGNVKSNSYWEAELPPNYDRVGIENFIRAKYEEKRWVARDGIPNSPSRLQENKAPTQWQRPAERSGGTSYFESPSEEKKSFQAHGTKSNIHATKTGSTKSNIPATKTGLPVPPKGSEPVIRKAEAETTKEVAEAVSPPKVDVATDLFDMLSMEDGPAENAVGENSSSETTGPSEPVDNKAKSTSEIDDLFKDSPPISQPNASDKPQKDVKSDILSLFEKQQLAMLAQQQSLLMAAASTSGGLPNFSGNGQQPVPSGANLPNQNWLNADKKHGSSKFSFYTMGPQVGTNEMPLPGAALPGATTQNAYLNNAGSSGASKPQSATLPVSSGSSSSSSQSSAKDYDFSSLTQGMFSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEJ5</accession>
    <name>A0A124SEJ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pyruvate kinase</fullName>
            <ecNumber evidence="18">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_021480</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="18"/>
    <dbReference type="EMBL" id="LEKV01003393">
        <property type="protein sequence ID" value="KVI00287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEJ5"/>
    <dbReference type="STRING" id="59895.A0A124SEJ5"/>
    <dbReference type="Gramene" id="KVI00287">
        <property type="protein sequence ID" value="KVI00287"/>
        <property type="gene ID" value="Ccrd_021480"/>
    </dbReference>
    <dbReference type="OMA" id="GIICTIX"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000005">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 18" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0630">Potassium</keyword>
    <keyword evidence="16 21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="19">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="20">
        <location>
            <begin position="378"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI00287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="54935" checksum="A75BAC2C03694471" modified="2016-04-13" version="1">MDQMNTDQSLQQVGVKRPRTKIVCTLGPASRSVPMVEKLLKAGMNVARFNFSHGSFEYHQETLDNLRTAMDNTGILCAVMLDTKGPEIRTGFLKDGKPIQLKQGVEITISTDYDIKGDDKMICMSYKKLAHDVKPGSVILCADGTISFTVLSCDTEKGLVRCRCENTAVLGERKNVNLPGVIVDLPTLTEKDKEDILKWGVPNKIDMIALSFVRKGSDLIEVRKLLGDHAKNILLMSKVENQEGVANFDDILANSDAFMVARGDLGMEIPIEKIFLAQKVMIYKCNLQGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPEVAVRTMAKICIEAENTIDYADVFKRIAANAPVPMSPLESLASAAVRTANSSRATLILVLTRGGSTAKLVAKYRPGMPILSVVVPEIKTDSFDWSCSDETPARHSLIFRGLVPVLSGGSARASHAESTEEALDFALQHAKGKGLCKVGDAVVALHRVGAASIIKIVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHX7</accession>
    <name>A0A124SHX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pollen Ole e 1 allergen/extensin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000981">
        <property type="protein sequence ID" value="KVI10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHX7"/>
    <dbReference type="Gramene" id="KVI10908">
        <property type="protein sequence ID" value="KVI10908"/>
        <property type="gene ID" value="Ccrd_010689"/>
    </dbReference>
    <dbReference type="OMA" id="CAAGNNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040404">
        <property type="entry name" value="Phylloplanin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34458:SF5">
        <property type="entry name" value="POLLEN OLE E 1 ALLERGEN AND EXTENSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34458">
        <property type="entry name" value="POLLEN OLE E 1 ALLERGEN AND EXTENSIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="14877" checksum="4B52640C8D60BAE6" modified="2016-04-13" version="1">MVALAFKLADAQFSRLQNLINISGSISCSLNGSIIANCTIPTPSRFSHALIDVSCGGNVISSAITNGSGMFDITLNPLQFSPNNLLSSNCNVRVVTPLSNCNTTLPSTGILQSPLQFIRTTTRGLTSVFNLVPSTFELIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SIE9</accession>
    <name>A0A124SIE9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SIE9"/>
    <dbReference type="STRING" id="59895.A0A124SIE9"/>
    <dbReference type="Gramene" id="KVI12481">
        <property type="protein sequence ID" value="KVI12481"/>
        <property type="gene ID" value="Ccrd_009072"/>
    </dbReference>
    <dbReference type="OMA" id="CIGKQKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="225" mass="26273" checksum="15D7247C6DCEC884" modified="2016-04-13" version="1">MVSLKLQKRLAASVLKCGRGKVWLDPNEGNEISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARRMKEAKRKGRHSGYGSPPLLFEVEFWSAVIPPPIGKRKGTREARLPTKILWMRRMRVLRRLLRKYRESKKIDKHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKLARREERLAQGPQEKVPAPAAQPAQASKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103PMK7</accession>
    <name>A0A103PMK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008282">
        <property type="protein sequence ID" value="KVG33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103PMK7"/>
    <dbReference type="STRING" id="59895.A0A103PMK7"/>
    <dbReference type="Gramene" id="KVG33797">
        <property type="protein sequence ID" value="KVG33797"/>
        <property type="gene ID" value="Ccrd_026476"/>
    </dbReference>
    <dbReference type="OMA" id="PHEANEF"/>
    <dbReference type="OrthoDB" id="1878267at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044797">
        <property type="entry name" value="At4g06598-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835:SF3">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="43429" checksum="28E15B4DB303751F" modified="2016-04-13" version="1">MANSRGPSTTRNMMYNGRHSLLPPKCPFPSIAPSYSDYISSAAIGPKGTPNYRDGNPHHQRASSESLLVEEQPSWLDELLNEPETPEQRGHRRSSSDSFTFLEAANAANTEYAVKNEHWMRNLTSAPSWASQDFDFYKDAQNMSFYAEPNPVINNKTRTWDSPQNSHSTGTASSRHNSGLRRTVSLGASQQLNGIASTTNEKQDAAEAGPQDSAETGPQDINTSERKDSSNTKPFASETDTKRAKQQFAQRSRVRKLQYIAELERNVQALQAEGSEVSAELEFLNQQSLILSMENKALKQRLDNLAQEQLIKCLEHEVLEREIGRLRALYQQQQQQQQPQPQQQPPLTHRQTSIRDRLDSQFANLSLKNKDSSTCVRDPVSSQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103PUQ8</accession>
    <name>A0A103PUQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Photosynthetic reaction centre, L/M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_026460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008239">
        <property type="protein sequence ID" value="KVG37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103PUQ8"/>
    <dbReference type="Gramene" id="KVG37572">
        <property type="protein sequence ID" value="KVG37572"/>
        <property type="gene ID" value="Ccrd_026460"/>
    </dbReference>
    <dbReference type="OMA" id="XTALGIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
        <property type="entry name" value="Photosystem II protein D1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055266">
        <property type="entry name" value="D1/D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036854">
        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149:SF12">
        <property type="entry name" value="PHOTOSYSTEM II D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PHOTOSYSTEM II PROTEIN D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="Bacterial photosystem II reaction centre, L and M subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="14" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="18" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVG37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15592" checksum="0664373ACC108EBA" modified="2016-04-13" version="1">MIVFQAEHNILMHPFHMLGVXGVFGGSLFSVMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGIWXTALGISTMAFNLNGFSFNQSVVDNQGRVINTWAGIINRANLGMEVMHERNAHNFPLDLAAIEAQSTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103STK6</accession>
    <name>A0A103STK6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007369">
        <property type="protein sequence ID" value="KVG94557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103STK6"/>
    <dbReference type="STRING" id="59895.A0A103STK6"/>
    <dbReference type="Gramene" id="KVG94557">
        <property type="protein sequence ID" value="KVG94557"/>
        <property type="gene ID" value="Ccrd_026073"/>
    </dbReference>
    <dbReference type="OMA" id="LNANTIW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051502">
        <property type="entry name" value="RLP_Defense_Trigger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062:SF21">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG94557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="26143" checksum="9CB4D1B15057A3DB" modified="2016-04-13" version="1">MLESLNLKNDSLSHIILNANTIWLDVSENHINGIILGDIRMFLPNIWILNLSRNSLDGIIPSSISDLSELGTLDLSEVSSGLFTNLSYIRVLKLSKNRLHGQVLSRNLSLGNHERLSLDNNYFTRKIGNWTIQNNYTQIIKYLHLGSNKFTGSIPNAFRNLAGVLTLDISNNFSLRKKKKNNFIGSIPMQLCQLSNVSLIDLSSNSLFGSIPRCLQNIRTLVYPAFKLSGQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UWN9</accession>
    <name>A0A103UWN9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006847">
        <property type="protein sequence ID" value="KVH43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UWN9"/>
    <dbReference type="Gramene" id="KVH43037">
        <property type="protein sequence ID" value="KVH43037"/>
        <property type="gene ID" value="Ccrd_025750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="97" mass="10875" checksum="DABD0139ECDB08BE" modified="2016-04-13" version="1">MLDIIGAMNDLFMIPYEEEEEVYENGVKPRDIDLVMTKVGVSSIAIDVLHWDSRHTMMLPRQFGSQASGLALGLTGPGARMTQMALVRSVHELRWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBK2</accession>
    <name>A0A103XBK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005933">
        <property type="protein sequence ID" value="KVH87692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBK2"/>
    <dbReference type="STRING" id="59895.A0A103XBK2"/>
    <dbReference type="Gramene" id="KVH87692">
        <property type="protein sequence ID" value="KVH87692"/>
        <property type="gene ID" value="Ccrd_025027"/>
    </dbReference>
    <dbReference type="OMA" id="VINVCCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000166">
        <property type="entry name" value="Thioredoxin-like protein AAED1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF23">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="29309" checksum="B35F8864EF24ADDF" modified="2016-04-13" version="1">MAITVSPPTITSSFSQLSSLSPFQSPPSLSYPSFSSSPTITRPLNLYPNRNNRTVVVPKASSTTTFSPEIADVLGEVNIFTASGDSVMFNELWDQSEGIAVVALLRHFGCPCCWELASTLKEYKARFESAGVKLIAIGIGEPKKARILAERLPFPLDILYADPERKLLSHCMSLKLLGIHVSQAYDVLGLYYGIGRTFFNPASALQKAVKNYTIEATPDDRGSVLQQGGMFVFKGKELLYAWKDEGTGDHAPLDDIFNICCSTKVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBT3</accession>
    <name>A0A103XBT3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannose-binding lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the jacalin lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005810">
        <property type="protein sequence ID" value="KVH87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBT3"/>
    <dbReference type="STRING" id="59895.A0A103XBT3"/>
    <dbReference type="Gramene" id="KVH87809">
        <property type="protein sequence ID" value="KVH87809"/>
        <property type="gene ID" value="Ccrd_024904"/>
    </dbReference>
    <dbReference type="OMA" id="WIQSAGG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09612">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033734">
        <property type="entry name" value="Jacalin-like_lectin_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46506">
        <property type="entry name" value="OS05G0143600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="146" mass="15966" checksum="4C8AACED662A8683" modified="2016-04-13" version="1">MASQVEVGPWRGDGGVNPWTFKPNGRIVGFRIASGDVIDSIRFTYEDNSQVSHHSDTYGGDGGTLNLPAKFDDDEDLIRVSGTIGKFYSITVITSLSFHSNKGKSYGPYGRGDRTSFSLPVTKGKFIRFFGNYGDFLDSIGVILQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBV3</accession>
    <name>A0A103XBV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin SPT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005761">
        <property type="protein sequence ID" value="KVH87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBV3"/>
    <dbReference type="STRING" id="59895.A0A103XBV3"/>
    <dbReference type="Gramene" id="KVH87860">
        <property type="protein sequence ID" value="KVH87860"/>
        <property type="gene ID" value="Ccrd_024826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="15976" checksum="84676C2E362ACE2E" modified="2016-04-13" version="1">MMLDRPSRYLSFSAVGSRDGFGVKAGPSGQKPGTASKLNSTSLEPRKQLGRNDGSGSARPSAPKTLPLKAPMVRKEKVISASVATGSMPGLHKLLHSKPAPSVHKKPYDDDDDRDMEAGFDDIMMEEKRRSVSLQNSLDNLDLILLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBZ9</accession>
    <name>A0A103XBZ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_024751</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005691">
        <property type="protein sequence ID" value="KVH87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBZ9"/>
    <dbReference type="STRING" id="59895.A0A103XBZ9"/>
    <dbReference type="Gramene" id="KVH87933">
        <property type="protein sequence ID" value="KVH87933"/>
        <property type="gene ID" value="Ccrd_024751"/>
    </dbReference>
    <dbReference type="OMA" id="ITHEQTC"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011108597" description="pectinesterase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="14">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="650" mass="73232" checksum="241DF0F060890E06" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDN5</accession>
    <name>A0A103XDN5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF538 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005330">
        <property type="protein sequence ID" value="KVH88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDN5"/>
    <dbReference type="STRING" id="59895.A0A103XDN5"/>
    <dbReference type="Gramene" id="KVH88831">
        <property type="protein sequence ID" value="KVH88831"/>
        <property type="gene ID" value="Ccrd_025283"/>
    </dbReference>
    <dbReference type="OMA" id="RCDIILP"/>
    <dbReference type="OrthoDB" id="744548at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF172">
        <property type="entry name" value="OS01G0595400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118702" description="DUF538 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17161" checksum="E2AB65C05F4ABEB0" modified="2016-04-13" version="1">MANSLIFFLFPLALLISISTSIPNPNKPSSNSLTAHSVLTSHGFPIGLLPTDVLSYDLNHTSGHFSVNLGYPCRLTLPPDNYLATYSKKITGKIVENRIAELNGIRVRAFFQWWGITGIKINGDDLVFEVGMVTAKYPAKNFDESPQCEGKKRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE85</accession>
    <name>A0A103XE85_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005309">
        <property type="protein sequence ID" value="KVH89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE85"/>
    <dbReference type="STRING" id="59895.A0A103XE85"/>
    <dbReference type="Gramene" id="KVH89130">
        <property type="protein sequence ID" value="KVH89130"/>
        <property type="gene ID" value="Ccrd_008880"/>
    </dbReference>
    <dbReference type="OMA" id="MIGESGC"/>
    <dbReference type="OrthoDB" id="409644at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054296">
        <property type="entry name" value="DUF7032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043:SF9">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23005">
        <property type="entry name" value="DUF7032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7032" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="546" mass="59195" checksum="1B2F5696826B2663" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XER9</accession>
    <name>A0A103XER9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005228">
        <property type="protein sequence ID" value="KVH89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XER9"/>
    <dbReference type="STRING" id="59895.A0A103XER9"/>
    <dbReference type="Gramene" id="KVH89361">
        <property type="protein sequence ID" value="KVH89361"/>
        <property type="gene ID" value="Ccrd_008648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125">
        <property type="entry name" value="F21J9.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125:SF3">
        <property type="entry name" value="NO-APICAL-MERISTEM-ASSOCIATED CARBOXY-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="159" mass="18581" checksum="D953832625931ABB" modified="2016-04-13" version="1" fragment="single">MEDKRSAAEYIKDEDKLLCQVYMQIAQDPIKGVYQTSDQFWSRVEGTYNNEKDTTWTVHPKRSLQSRSLQSRVLLIEKATRKLHACIRQYENRHQSGASNDIIKSNGCCQKIQNLRMVGNLIIFWSIIKEFEKFHDGNTRTKQIPIPIPNRDGFGCVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF53</accession>
    <name>A0A103XF53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family Cys-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005196">
        <property type="protein sequence ID" value="KVH89581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF53"/>
    <dbReference type="STRING" id="59895.A0A103XF53"/>
    <dbReference type="Gramene" id="KVH89581">
        <property type="protein sequence ID" value="KVH89581"/>
        <property type="gene ID" value="Ccrd_008411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="199" mass="22154" checksum="284EF7834A351A44" modified="2016-04-13" version="1">MKKMVENWGEVFLGCGKVIFLIVLMIVVCFFNHHCKCPWFRFGENMKLAGLGSCFLQGFIYTILSTLALCNLVAFAVTKKHCFLYIGVAFVLSLGTYLGFNRSKMRSKFNIKGSDSSLDDCVSHLICPCCTLAQESRTLKMNNIQDGTWHGRGDTMCMGTYVEGVKAFELIPPTIVSIESPKPCLPAEGSEPLASPRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGG4</accession>
    <name>A0A103XGG4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_007721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGG4"/>
    <dbReference type="STRING" id="59895.A0A103XGG4"/>
    <dbReference type="Gramene" id="KVH90261">
        <property type="protein sequence ID" value="KVH90261"/>
        <property type="gene ID" value="Ccrd_007721"/>
    </dbReference>
    <dbReference type="OMA" id="ANICRIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF98">
        <property type="entry name" value="MALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="13">
        <location>
            <begin position="306"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH90261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="516" mass="56077" checksum="12A85E37B87A4213" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGN6</accession>
    <name>A0A103XGN6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase, family 79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGN6"/>
    <dbReference type="Gramene" id="KVH90278">
        <property type="protein sequence ID" value="KVH90278"/>
        <property type="gene ID" value="Ccrd_007734"/>
    </dbReference>
    <dbReference type="OMA" id="NITVPAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000023">
        <property type="entry name" value="heparanase-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF45">
        <property type="entry name" value="HEPARANASE-LIKE PROTEIN 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="601" mass="66631" checksum="D0274C997AFD4936" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ38</accession>
    <name>A0A103XJ38_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004909">
        <property type="protein sequence ID" value="KVH91710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ38"/>
    <dbReference type="STRING" id="59895.A0A103XJ38"/>
    <dbReference type="Gramene" id="KVH91710">
        <property type="protein sequence ID" value="KVH91710"/>
        <property type="gene ID" value="Ccrd_006240"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="26077" checksum="6184D7E9B4C71A47" modified="2016-04-13" version="1">MNGGRDGRNIIHIIGGHGPRRGADNRDDQPVSGREEFEIPSLGSPRFIIEKLRSSRVRHCRKFSSEEGCPFGDKCTYLHDDKMKGRERTAILLGPGSSVGYGNGGATGSGSGTAAAPPLAPPPLALPLAAAPAAAPLVSAASNSTVKPSWKTKICYKWERTGNCPYGSKCIFAHGAAELHRYGGGLLVDDEANPNQQVNVVAATRSSVAHVGGSGLPPATSERPVRKWKGPDKISRIYGDWIDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJG7</accession>
    <name>A0A103XJG7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase archaeal subunit P/eukaryotic subunit RPC10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_006165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJG7"/>
    <dbReference type="STRING" id="59895.A0A103XJG7"/>
    <dbReference type="Gramene" id="KVH91793">
        <property type="protein sequence ID" value="KVH91793"/>
        <property type="gene ID" value="Ccrd_006165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH91793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="71" mass="8400" checksum="457CD22C46103D10" modified="2016-04-13" version="1" fragment="single">LEKPLQNPRYDYFASRFRRSQIGDANNRIGDSADCGQENTLKVGDVIQCRECGYRILYKKRTRRIVQYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMC4</accession>
    <name>A0A103XMC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004780">
        <property type="protein sequence ID" value="KVH93328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMC4"/>
    <dbReference type="STRING" id="59895.A0A103XMC4"/>
    <dbReference type="Gramene" id="KVH93328">
        <property type="protein sequence ID" value="KVH93328"/>
        <property type="gene ID" value="Ccrd_004631"/>
    </dbReference>
    <dbReference type="OMA" id="WRMYNEI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000033">
        <property type="term" value="P:regulation of seed dormancy process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010029">
        <property type="term" value="P:regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009739">
        <property type="term" value="P:response to gibberellin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118928" evidence="8">
        <location>
            <begin position="23"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="51251" checksum="1ED4F31F95461BE5" modified="2016-04-13" version="1">MATSVLQTVLLVLALLLCISSAEYLTVDSFINHSQSYDGGLCVNLVEPCGYTCSEHTIQTKDGFLLGLQRVSSSIVNLELQSAPPVLLLHGLFMGGDAWFMDSAKQSLGFILPDHGFDVWVGNVRGTKWSHGHVSLSERDKDFWDWSWQELALYDLEAMLRYIKSETSSKVFVVGHSQGTIMSLAAFTQPDIADLVEAAALLSPISYLDHITSKFVLNLVQMHLDEVSFSSLIQIYVNLILEVSYIKIFFTGTWITGNTSIKHEEVFCFPFLLFFSAFTRPRLIIDDIYAVLSDILTNIIDLACDGHVDCSDMLASITGENCCFNSSRVDFYLEYEPHPSSLKNLKHLFQMIRKGTFARYDYGSLKNVLQYGQTKPPSFDLGQIPESLPIWMAHGGNDALGDVIDVHHTLSELPSKPNVLFLENYGHIDFLLSTRAYEDLYGNMIRFFKSCGMSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPR5</accession>
    <name>A0A103XPR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha crystallin/Hsp20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004544">
        <property type="protein sequence ID" value="KVH94608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPR5"/>
    <dbReference type="STRING" id="59895.A0A103XPR5"/>
    <dbReference type="Gramene" id="KVH94608">
        <property type="protein sequence ID" value="KVH94608"/>
        <property type="gene ID" value="Ccrd_003320"/>
    </dbReference>
    <dbReference type="OMA" id="KLEVDVW"/>
    <dbReference type="OrthoDB" id="1922291at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33879">
        <property type="entry name" value="17.6 KDA CLASS II HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33879:SF12">
        <property type="entry name" value="HSP20-LIKE CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118973" description="Alpha crystallin/Hsp20 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22305" checksum="2F9191D51C555F40" modified="2016-04-13" version="1">MIPFSFGNRPNVFQVSILLNLIQLFFTTSGSSLHINNPSHLNQSTIEIHQFIDPNPNSVSSPMPAKKLRRLPHVFSKVLELPLRSNADVFIEDRSECFRFRAKIEDNAFSGEVKAHAVKIHPEVTKVVVRGGNGGGEVELLLDKLEVDVWRFRLPATSRPELATAVFLGGELIVTVPKAWKVEDGKGRLGRLQGRLVYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQV3</accession>
    <name>A0A103XQV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQV3"/>
    <dbReference type="STRING" id="59895.A0A103XQV3"/>
    <dbReference type="Gramene" id="KVH95208">
        <property type="protein sequence ID" value="KVH95208"/>
        <property type="gene ID" value="Ccrd_002706"/>
    </dbReference>
    <dbReference type="OMA" id="SGGFEQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34285">
        <property type="entry name" value="OS08G0510800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34285:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="39513" checksum="872E858C3424466A" modified="2016-04-13" version="1">MKLSLKLEDQQQNQNPILFKAKIPIAVFGLPFLSAFSATHHHAAAASDKLSLSLRTHFPTGPSLKLSYNTPTTTANSGAAASAPLTLTLKSGVSFSGSPNNSPLIISANFSFSPQNPNPNPTFSIQFKPRLGSFSLRKTVSSSPVSNAGKTLNGGSTDGRDNSYGFVPLDRPINWKELTVESATKDSILSGILMAANTELPVTKRVKVNLRWGVNIPPDYEKQLPYLRVNKIKVERIDEVNEEKGNQKQRIEGDSGEFAMLKGMYSWMSRELNDLQKENREMRRILEEIKSRQPLKSYNGYSSGGGGGKRPQPLVESLDGAEQWRMKKSGDVNGQRETKKNATSMDVESELQRAIKAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRM9</accession>
    <name>A0A103XRM9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRM9"/>
    <dbReference type="STRING" id="59895.A0A103XRM9"/>
    <dbReference type="Gramene" id="KVH95613">
        <property type="protein sequence ID" value="KVH95613"/>
        <property type="gene ID" value="Ccrd_002368"/>
    </dbReference>
    <dbReference type="OMA" id="RRPHICA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21371">
        <property type="entry name" value="cwf21_RRC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12223">
        <property type="entry name" value="RRM_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047491">
        <property type="entry name" value="RRC1-like_cwf21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035009">
        <property type="entry name" value="SR140_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="193"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="415"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="931" mass="105023" checksum="66405F549C88E50E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSA8</accession>
    <name>A0A103XSA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSA8"/>
    <dbReference type="STRING" id="59895.A0A103XSA8"/>
    <dbReference type="Gramene" id="KVH95976">
        <property type="protein sequence ID" value="KVH95976"/>
        <property type="gene ID" value="Ccrd_001927"/>
    </dbReference>
    <dbReference type="OMA" id="MVSACID"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690:SF80">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690">
        <property type="entry name" value="TRANSCRIPTION FACTOR POSF21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="47818" checksum="A4F42FEAD96BDD6B" modified="2016-04-13" version="1">MPPAHPQIRSLSPPSQIPVMQSPETEGSHSRSLSQTSFFPVDSLPQLSLSPTSALTSDQVVTDVSMEDHDLLPPSLGRENSARISENLPPRKTHRRSNSDIPFGFSTILQSSPPLIPLRGSKGLDGSASLRNNPGSKPVQYVKWESSWEKTSGESNAKGIEERKCEGEVVDDLFSAHTVFNNLDGLNSSRAENREDLDSRASGTKAHVGDGSDNEATSSVNGGVVNNMQRSGISSIFDKREGIKRSAGGDIAPTMRHYRSVSMDSIMGKMNFADELLKLPPSPEGCINKFPPSDSINANSDTFNLEFGNGMILANRQSAARSKERKMRYIVELENKVQTLQTETTSLSTQLMLLQRDSTSLTSQNNELKFRLQAMEQQAQLRDALNEALTADVQRLKIMTTELSGDAAKFSQLSLNPQMFQLHQQQQNGCATTTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSM7</accession>
    <name>A0A103XSM7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSM7"/>
    <dbReference type="STRING" id="59895.A0A103XSM7"/>
    <dbReference type="Gramene" id="KVH96139">
        <property type="protein sequence ID" value="KVH96139"/>
        <property type="gene ID" value="Ccrd_001783"/>
    </dbReference>
    <dbReference type="OMA" id="FHWTKAS"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF48">
        <property type="entry name" value="ZINC TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119067" evidence="9">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="336" mass="35963" checksum="9A569EA247E62481" modified="2016-04-13" version="1">MAFSSKMVPIFIVFMAFLCTKAFSQCEDETNNPCNNKSKAFSLKIIGIAVILVTSIIGVCLPLVTRSIPALSPDRSLFVVVKAFASGIILATGFMHVLPDSFDMLRSSCLADNPWHKFPFTGFVAMLSAIFTLMVDSMATSTYTKKNNAISAEDHEMAATSFHGHHHTQKGPIGSQLLRYRVVAMVLELGIVVHSIVIGLGVGASNDVCTIKPLVAALCFHQMFEGMGLGGCILQAEYKTLKKAVMVFFFSITTPFGIALGIALSKTYKENSPSALITVGLLNASSAGLLIYMALVDLLAADFMGPKLQGSIKLQIKSYAAVLLGAGGMSLMAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT58</accession>
    <name>A0A103XT58_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004308">
        <property type="protein sequence ID" value="KVH96440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT58"/>
    <dbReference type="STRING" id="59895.A0A103XT58"/>
    <dbReference type="Gramene" id="KVH96440">
        <property type="protein sequence ID" value="KVH96440"/>
        <property type="gene ID" value="Ccrd_001475"/>
    </dbReference>
    <dbReference type="OMA" id="DVIGTMM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="15940" checksum="8A69ED76B439E1EB" modified="2016-04-13" version="1">MCPTGTSLWPARNISDLRSAFEVLDVDRDGKISREDLKTSYADADDDVIGTMMTVADANQNGYVEYDEFEKVLRSNNNGSGGVMEDVFKAMDGDGDGKVGYGDLRSYLLSAGFEVNDDEIKAMIRLGGVDGDTEGVTFEGFLKILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU20</accession>
    <name>A0A103XU20_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_001052</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004132">
        <property type="protein sequence ID" value="KVH96856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU20"/>
    <dbReference type="STRING" id="59895.A0A103XU20"/>
    <dbReference type="Gramene" id="KVH96856">
        <property type="protein sequence ID" value="KVH96856"/>
        <property type="gene ID" value="Ccrd_001052"/>
    </dbReference>
    <dbReference type="OMA" id="PEVIHEK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000653">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF3">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="15">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH96856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="450" mass="50998" checksum="65C8E02C43E60454" modified="2016-04-13" version="1">MENQGRILMQRYELGKLLGQGTFAKVYHARNLKTNKSVAVKVISKEKVMQNGLIDQIKREISVMRLVKHPNVVQLYEVMASKTKIYFAMEYVNGGELFDKVAKGRLKEDAARKYFQSLVAAVDFCHSRGVYHRGLKPENLLLDKSGNLKVSDFGLSALVDSKRQDGLLHTTCGTPAYVAPEVIHNKGYDGEKADIWSCGVILFVLLAGYLPFSDPNLMRMYRKISKANFKCPNWFPPEVKKLLSKILDPNPETRISIAKIMENPWFQKEFKKIETYYVPRSILDDENVIKYTDSPKCSSTDLKQLEERAIKKNSSNLGTLKPTRMNAFDIISLSPGFDLSGLFENNVPSKKTEARFTTKKSASAIMSKLEEMASTEQLQIVKTLDGTVTMQGCKEGRKGQLAIRAEIFEVTPSFHMVEIKKLGGDTIEYENYFDQELKPSLKDIIWKMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU31</accession>
    <name>A0A103XU31_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004034">
        <property type="protein sequence ID" value="KVH96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU31"/>
    <dbReference type="STRING" id="59895.A0A103XU31"/>
    <dbReference type="Gramene" id="KVH96932">
        <property type="protein sequence ID" value="KVH96932"/>
        <property type="gene ID" value="Ccrd_000975"/>
    </dbReference>
    <dbReference type="OMA" id="WWENNTS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000032">
        <property type="entry name" value="Transcription factor bHLH123 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF238">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="44637" checksum="DAA81C2CF24CEC03" modified="2016-04-13" version="1">MAKEIQAVVYGGSWWMSPRTAFNRLSCSSVITDMENFGPCWPRDLMDIKSKSSDESLDGSMVFQDIRRRPGGGATTMSPDSSFQMMATAFPDSPMTTNPDWNQDLLFRVQEGLNTFSTSGDGGSKAVTTAEHQRFTMDQPQSLNFITSSGDPATFPVSSTSYDYPSSLLETLYDSSPPPPSQHPLYSFESNSNDFHFVQSLPSMCPKQQVSGHLHLTNSIPFWNASTSTLESPSQFLPSSYKEKQRSSNLTIQPHHQEIRDSGSTEKKSSGELPFKRPWLETPSPLPTFKVRKEKLGDRITALQQLVSPFGKTDTASVLHEAIEYIKLLHDQVNILSAPYMKNGLTKQLQQIHDHKVKDTEGPKQDLRSLGLCLVPVSSMFPVAIETTSGFWTPNFEGSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU72</accession>
    <name>A0A103XU72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003910">
        <property type="protein sequence ID" value="KVH96978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU72"/>
    <dbReference type="STRING" id="59895.A0A103XU72"/>
    <dbReference type="Gramene" id="KVH96978">
        <property type="protein sequence ID" value="KVH96978"/>
        <property type="gene ID" value="Ccrd_000928"/>
    </dbReference>
    <dbReference type="OMA" id="KGHRQVK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11003" checksum="2088F0097C7A6F98" modified="2016-04-13" version="1">MLGSKTQTMIGRPVLPEAAVHAVVEEHALDAKVIIFKKKRRKNYRRKKGHRQVKLDQFTELTKLRITDIQGIEKPEMPTSAKTEKAAAKKVEKAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUH0</accession>
    <name>A0A103XUH0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003868">
        <property type="protein sequence ID" value="KVH97051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUH0"/>
    <dbReference type="STRING" id="59895.A0A103XUH0"/>
    <dbReference type="Gramene" id="KVH97051">
        <property type="protein sequence ID" value="KVH97051"/>
        <property type="gene ID" value="Ccrd_000855"/>
    </dbReference>
    <dbReference type="OMA" id="MQIYKSP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF683">
        <property type="entry name" value="OS05G0506800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="35510" checksum="01283E271F432F3B" modified="2016-04-13" version="1">MADSSTNTIFLLLTTLIFTTSCTFYVNGCYTSIISFGDSLADTGNMKALSPKSNGQAPHFLFPPYGETFFHKPTGRCSNGRLIIDFIAESLGLPLIPASEAGKTTELAQGVNYAVAGATALDSSFHEARGVYNPMTNASLRVQLGWFKESLPSFCSTVSGNLPIGCSAAYLTIFYDSDKVQYDNSTGCIIRLNRFAEYHNELLQTELTQIREVHPEVNIIYADYYNAAMQFFRSPNKYGFTNGALKACCGGGGPFNYNPSIACADPSSNSCAQPDTYFNWDGLHLTEAAYRLVFKSLFEGSYTTPRFNSLCPISRSQPVGGLSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUL3</accession>
    <name>A0A103XUL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Gnk2-homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_000793</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell junction</location>
            <location evidence="12">Plasmodesma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003856">
        <property type="protein sequence ID" value="KVH97111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUL3"/>
    <dbReference type="STRING" id="59895.A0A103XUL3"/>
    <dbReference type="Gramene" id="KVH97111">
        <property type="protein sequence ID" value="KVH97111"/>
        <property type="gene ID" value="Ccrd_000793"/>
    </dbReference>
    <dbReference type="OMA" id="CYVRYEN"/>
    <dbReference type="OrthoDB" id="1097929at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000011">
        <property type="entry name" value="Cysteine-rich repeat secretory protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000001">
        <property type="entry name" value="cysteine-rich repeat secretory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051378">
        <property type="entry name" value="Cell2Cell_Antifungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080">
        <property type="entry name" value="ANTIFUNGAL PROTEIN GINKBILOBIN-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080:SF2">
        <property type="entry name" value="PLASMODESMATA-LOCATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="15">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="15">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH97111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="30877" checksum="E516E87CA0AD3D88" modified="2016-04-13" version="1">MMFKFRRLPSTLFLLFIIVVFFSYLVKSRIFIYYGCSEEKFKPNTPFETNLNSLLSLFVSSSSQGLYNSFAIGNDTDTSSESPIYGLYQCRGDLRTPDCTKCIEGAVSQVGLACPYSYSGSLQLDKCLVRFEHFDFLGKLDTDLRFKKCSTSVSHDMQFLKRRDEVLVELGETNQGFRISSSSSIEGFSQCLGDLSPDDCNSCLGEAITKLKNLCGSSEAGDVFLAQCYMRYWISGYHDSPSESSGGDDVGKTIAIVIGVVAGLTAFIVLISFCRRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUS1</accession>
    <name>A0A103XUS1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="LEKV01003841">
        <property type="protein sequence ID" value="KVH97293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUS1"/>
    <dbReference type="STRING" id="59895.A0A103XUS1"/>
    <dbReference type="Gramene" id="KVH97293">
        <property type="protein sequence ID" value="KVH97293"/>
        <property type="gene ID" value="Ccrd_000613"/>
    </dbReference>
    <dbReference type="OMA" id="WRIDENP"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF44">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="310" mass="35038" checksum="50E52E436FA2F916" modified="2016-04-13" version="1">MGHSAAVWDSKIATENVKDWNGIDQIVLRNPHGASARVSLHGGQVISWRNDRGEELLFTSSKANGKAPKPMQGGIPICFPQFGSCGSLEQHGFARKKIWIVDQDPPSLPANDSNRKSFIDLLLKPSEEDLKFWPHSFELRLRVCLGMDGNLTLISRVRNIDGKPFSFSFAYHSYLSVSDISEVRIEGLETMDYFDNLCHKERFTEQGDAITFESEFDRVYLSSPNCVAVLDHERKRTYVLRKEGLPDVVVWNPWDKKSKAMADLGDDEYRQMICVDGAVIEKPISLKPGEEWKGRLEIVVVPSSFCSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW51</accession>
    <name>A0A103XW51_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_023746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW51"/>
    <dbReference type="STRING" id="59895.A0A103XW51"/>
    <dbReference type="Gramene" id="KVH98003">
        <property type="protein sequence ID" value="KVH98003"/>
        <property type="gene ID" value="Ccrd_023746"/>
    </dbReference>
    <dbReference type="OMA" id="GYRPYNK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF87">
        <property type="entry name" value="LIPID DESATURASE ADS3.2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="13">
        <location>
            <begin position="53"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH98003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="34922" checksum="206DED1DA0EC8785" modified="2016-04-13" version="1">MVAVFSGVNEFEYEKVPFSDVVITRKRNLLWGRKWRAANIKMVIIVFAIHLLALFAPFAYVLCELFGIMLSYHRNLTHHSFKLPKWLEYIFAYVGLLAFQGDPIFWVSTHRYHHQYVDTEKDPHSPTNGFWFSHMGWLFDGGSVIEKYQDRKNVEDLKSQKFYRFLNRTHGFHVYSFTALVYAFGGFTYLVWVVGVSTVCIYHATFFVNSVCHIWGNQTWDTGDLSKNNWWMALITFGDGWHNNHHAFEYSARHGLEWWQVDFVWYVIRFLEALGLATNVKLPTEAQKLKKSFAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX73</accession>
    <name>A0A103XX73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01003794">
        <property type="protein sequence ID" value="KVH98509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX73"/>
    <dbReference type="STRING" id="59895.A0A103XX73"/>
    <dbReference type="Gramene" id="KVH98509">
        <property type="protein sequence ID" value="KVH98509"/>
        <property type="gene ID" value="Ccrd_023265"/>
    </dbReference>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="12389" checksum="5510F3C963E27125" modified="2016-04-13" version="1">MGKDAKGGKGKAKQAGGSEDGGAKGKAKGGKSADGLGTCTYLQDGWLSNGDKVPPAEFAKIAAEYSECPSAKKGGDLGWFPRGKMAGPFQEVAFNTVVGATSPPFKSTHGYHIILAEGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXT4</accession>
    <name>A0A103XXT4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003647">
        <property type="protein sequence ID" value="KVH98852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXT4"/>
    <dbReference type="STRING" id="59895.A0A103XXT4"/>
    <dbReference type="Gramene" id="KVH98852">
        <property type="protein sequence ID" value="KVH98852"/>
        <property type="gene ID" value="Ccrd_022931"/>
    </dbReference>
    <dbReference type="OMA" id="GSCKVVQ"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF8">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119204" evidence="4">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="38728" checksum="E43F760570223FAC" modified="2016-04-13" version="1">MKLLLVVLATLLSGFIHGYDCKIVQFIFGDSLSDNGNNNRLTKSFAQAALPWYGIDFGSGIPNGRFTNGRTVADIIGDKTGVPRPPPFLDPSLSEDVILANGVNFASGGGGILNETGGLFIQRFSLYKQIELFNGVQRLIRGTIGDEKANKFFQEAKYVVALGSNDFINNYLMPVYADSWTYNDDTFISYLMETLRAQLMVLHGMGARQLMVFGLGPMGCIPLQRVLSTSGGCQEKTNTLALNFNKATAKLMDELSAKLPNASYQFGDAYDVVNNVITNPKKYGFDNADSPCCSFGRIRPALTCIPASRLCKDRSKYLFWDEYHPSDRANELIADELIRKLRFKPVNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXZ5</accession>
    <name>A0A103XXZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXZ5"/>
    <dbReference type="Gramene" id="KVH98942">
        <property type="protein sequence ID" value="KVH98942"/>
        <property type="gene ID" value="Ccrd_022868"/>
    </dbReference>
    <dbReference type="OMA" id="FSHMEDQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15663" checksum="E1C792FCFE22C882" modified="2016-04-13" version="1">MASYGGTTQKCKACEKTVYLVDELTVDNRVYHRACFRCHHCKGTLKVPPKPLELIDPIRANLTAEYQVGVDGNAYHRACFKCSFGGCVISPSNYVAHEHQLYCKHHHAQLFMAKGNFSQFDKQHQQDVSNGVTENTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYW6</accession>
    <name>A0A103XYW6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01003607">
        <property type="protein sequence ID" value="KVH99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYW6"/>
    <dbReference type="STRING" id="59895.A0A103XYW6"/>
    <dbReference type="Gramene" id="KVH99345">
        <property type="protein sequence ID" value="KVH99345"/>
        <property type="gene ID" value="Ccrd_022423"/>
    </dbReference>
    <dbReference type="OMA" id="VHWPESK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1102">
        <property type="entry name" value="METHYLTRANSFERASE PMT28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="659" mass="74865" checksum="BE576706B70FD6FB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ20</accession>
    <name>A0A103XZ20_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003457">
        <property type="protein sequence ID" value="KVH99527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ20"/>
    <dbReference type="STRING" id="59895.A0A103XZ20"/>
    <dbReference type="Gramene" id="KVH99527">
        <property type="protein sequence ID" value="KVH99527"/>
        <property type="gene ID" value="Ccrd_022240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11384" checksum="BC1F6A163C4823DC" modified="2016-04-13" version="1">MVRSGRMDEVFDSMGEDETLPKGVMSRFVRIGLLCAHAMVALRPTSWEALKMLEGDIDIPRLPDRPLPLSHESFRLSFQRSNMSLWSSSEGSGASSSLNTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZS1</accession>
    <name>A0A103XZS1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003407">
        <property type="protein sequence ID" value="KVH99893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZS1"/>
    <dbReference type="Gramene" id="KVH99893">
        <property type="protein sequence ID" value="KVH99893"/>
        <property type="gene ID" value="Ccrd_021865"/>
    </dbReference>
    <dbReference type="OMA" id="NWHFFTM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
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        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="966" mass="104681" checksum="A6BECC578EB110D4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y042</accession>
    <name>A0A103Y042_CYNCS</name>
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        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003400">
        <property type="protein sequence ID" value="KVI00070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y042"/>
    <dbReference type="STRING" id="59895.A0A103Y042"/>
    <dbReference type="Gramene" id="KVI00070">
        <property type="protein sequence ID" value="KVI00070"/>
        <property type="gene ID" value="Ccrd_021691"/>
    </dbReference>
    <dbReference type="OMA" id="NACLCYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009624">
        <property type="term" value="P:response to nematode"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF119">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356249" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="28"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="321"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="345"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="589" mass="67189" checksum="24C53505D0A29B63" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y134</accession>
    <name>A0A103Y134_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003382">
        <property type="protein sequence ID" value="KVI00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y134"/>
    <dbReference type="Gramene" id="KVI00516">
        <property type="protein sequence ID" value="KVI00516"/>
        <property type="gene ID" value="Ccrd_021231"/>
    </dbReference>
    <dbReference type="OMA" id="YDELKCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF328">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="583" mass="66040" checksum="0CE7219F7B1C3D09" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2S6</accession>
    <name>A0A103Y2S6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003094">
        <property type="protein sequence ID" value="KVI01446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2S6"/>
    <dbReference type="STRING" id="59895.A0A103Y2S6"/>
    <dbReference type="Gramene" id="KVI01446">
        <property type="protein sequence ID" value="KVI01446"/>
        <property type="gene ID" value="Ccrd_020282"/>
    </dbReference>
    <dbReference type="OMA" id="MGVHESR"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="72" mass="7856" checksum="FF89111A23F06609" modified="2016-04-13" version="1">MSSKVVLKAKGKSTKGSKPSDDNSTSKLLKEWSTWTIKKAKVITHYGFIPLIIIIGMNSDPKPSISQLLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3D9</accession>
    <name>A0A103Y3D9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002683">
        <property type="protein sequence ID" value="KVI01799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y3D9"/>
    <dbReference type="Gramene" id="KVI01799">
        <property type="protein sequence ID" value="KVI01799"/>
        <property type="gene ID" value="Ccrd_019932"/>
    </dbReference>
    <dbReference type="OMA" id="MRIPDKL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="26520" checksum="48606C0B75AF260F" modified="2016-04-13" version="1">MVHSKLGLLHELGRNYLRRKQSSSGQASRCCSADRMDFSRLTDAMASRSFDKIGDVCDQLMLQLASQGVAFQEEWPYAVHLLGHIYLNDLNSARFLWKSIPSSIKENRPEVVAVWKIGQHLWTRNYAGVYDSIRGFNWSAEIQSFVASFAERYTKRMLELLMSAYSTISVQDTALFLGMNENDATSYVLQQGWNVDAASQMLTVKKQTVVTEXXIDPSKLQRLTEYVFHLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3L9</accession>
    <name>A0A103Y3L9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002672">
        <property type="protein sequence ID" value="KVI01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3L9"/>
    <dbReference type="STRING" id="59895.A0A103Y3L9"/>
    <dbReference type="Gramene" id="KVI01909">
        <property type="protein sequence ID" value="KVI01909"/>
        <property type="gene ID" value="Ccrd_019792"/>
    </dbReference>
    <dbReference type="OMA" id="QGPLMIG"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF106">
        <property type="entry name" value="PEROXISOMAL MEMBRANE 22 KDA (MPV17_PMP22) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="32797" checksum="517107AFE9A9D273" modified="2016-04-13" version="1">MLFPLPQTIRSRLLLPPNFWKPSFTNQHFSIKMNASVLRIGNKAHYHIWMRHSLSDSLGVQQHLQHSNAFYSRFPGRRATEMGFSVPVRALTTKTNGRTMSSSITNSGFVGWYLGMIKTRPILTKSITSALIYTAADLTSQTMSRLSSSSEGGYDVIRICRMAGYGLIILGPTLHLWFNFVSRVLPKQDLMATFKKMLMGQTIFGPIMTAVFFSVNAALQGESGEEIVARLNRDMVPTMINNVLYWPICDFITFRFVPVHLQPLVSNSFSYVWTIYITYMANLSKAAAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y418</accession>
    <name>A0A103Y418_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002663">
        <property type="protein sequence ID" value="KVI02120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y418"/>
    <dbReference type="STRING" id="59895.A0A103Y418"/>
    <dbReference type="Gramene" id="KVI02120">
        <property type="protein sequence ID" value="KVI02120"/>
        <property type="gene ID" value="Ccrd_019600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="49" mass="5230" checksum="AD3B483B902BE101" modified="2016-04-13" version="1">MMIMGVSIQLLMDLTVAGISLMIGFGIFAFIASILCSAAFFHNAKPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y513</accession>
    <name>A0A103Y513_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002647">
        <property type="protein sequence ID" value="KVI02660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y513"/>
    <dbReference type="STRING" id="59895.A0A103Y513"/>
    <dbReference type="Gramene" id="KVI02660">
        <property type="protein sequence ID" value="KVI02660"/>
        <property type="gene ID" value="Ccrd_019052"/>
    </dbReference>
    <dbReference type="OMA" id="QRAMIAG"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000051">
        <property type="entry name" value="(S)-hydroxynitrile lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF1083">
        <property type="entry name" value="METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="29924" checksum="0C0AA9268B767168" modified="2016-04-13" version="1">MDATRDQQKHFVLVHGACHGAWCWFKLKPLLEAAGHRVSAFDLSASGTNTKLIQQLTSLSDYSLPLLEFMATIPPEEKVVLVGHSLGGMNIALAMEKFPEKVSVAVFLTAFMPDSLHKASYVIDEYNERTPAEAWLDTQFLPFDENDVESETSMFFGPEFLSNKLYQLCSNEDRELGKMLIRPGSLFLKDLRSGLQFTEEGYASVQRVFIVCDEDKAIEKEFQRWMIDNNPVAGVKELKNVDHMSMLCDPKQLSVCLRDIGGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y639</accession>
    <name>A0A103Y639_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002414">
        <property type="protein sequence ID" value="KVI03201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y639"/>
    <dbReference type="SMR" id="A0A103Y639"/>
    <dbReference type="STRING" id="59895.A0A103Y639"/>
    <dbReference type="Gramene" id="KVI03201">
        <property type="protein sequence ID" value="KVI03201"/>
        <property type="gene ID" value="Ccrd_018499"/>
    </dbReference>
    <dbReference type="OMA" id="VSATAWI"/>
    <dbReference type="OrthoDB" id="757063at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090610">
        <property type="term" value="P:bundle sheath cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009630">
        <property type="term" value="P:gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048366">
        <property type="term" value="P:leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009956">
        <property type="term" value="P:radial pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="468"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="674"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LxCxE motif" evidence="3">
        <location>
            <begin position="393"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="499"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="749" mass="82049" checksum="A0983248E65175C7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6A3</accession>
    <name>A0A103Y6A3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002375">
        <property type="protein sequence ID" value="KVI03308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6A3"/>
    <dbReference type="Gramene" id="KVI03308">
        <property type="protein sequence ID" value="KVI03308"/>
        <property type="gene ID" value="Ccrd_018394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="114" mass="13403" checksum="F1A3D595D62F31F4" modified="2016-04-13" version="1" fragment="single">MMVKRFEEVALDCFSNHFIIRGEIKFQMISLGTTYACYLVYKITNAVDEIEEPVEVRNWNLPFSFSDEISYRYIYLLSPQSPVIKIRLDDDENSHNPPISQMPKIKGLPRLRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6Y2</accession>
    <name>A0A103Y6Y2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01002336">
        <property type="protein sequence ID" value="KVI03634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6Y2"/>
    <dbReference type="STRING" id="59895.A0A103Y6Y2"/>
    <dbReference type="Gramene" id="KVI03634">
        <property type="protein sequence ID" value="KVI03634"/>
        <property type="gene ID" value="Ccrd_018065"/>
    </dbReference>
    <dbReference type="OMA" id="GMNTGQT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF470">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="338" mass="38513" checksum="7BD242EB80F00EAE" modified="2016-04-13" version="1">MAQNGQGIDPALLDDIINRLLEFRQARTVRQVQLSESDIRQLCTVSREIFLQQPTLLELEAPIKLCGDIHGQYGDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNVRLWKTFTDCFNCLPVAALIDDKILCMHGGLSPDLTNLDQIRNLPRPTDVPDSGLLCDLLWSDPSRDVKGWGMSDRGVSYTFGADKVAEFLMQHDMDLVCRAHQVVEDGYEFFADRQLVTIFSAPNYCGEFDNAGAMMSVDESLIGDPNTFKNLPDALKYATDVLVIFLFRQECRNTFHQILAGLRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7G8</accession>
    <name>A0A103Y7G8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial Rho GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_017760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002320">
        <property type="protein sequence ID" value="KVI03941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7G8"/>
    <dbReference type="Gramene" id="KVI03941">
        <property type="protein sequence ID" value="KVI03941"/>
        <property type="gene ID" value="Ccrd_017760"/>
    </dbReference>
    <dbReference type="OMA" id="FWFAQKA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000935">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="15">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="15">
        <location>
            <begin position="421"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI03941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68633" checksum="7DF047A03C97AD89" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8H0</accession>
    <name>A0A103Y8H0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Cytoplasmic vesicle</location>
            <location evidence="5 6">COPI-coated vesicle membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Golgi apparatus membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002049">
        <property type="protein sequence ID" value="KVI04460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8H0"/>
    <dbReference type="STRING" id="59895.A0A103Y8H0"/>
    <dbReference type="Gramene" id="KVI04460">
        <property type="protein sequence ID" value="KVI04460"/>
        <property type="gene ID" value="Ccrd_017223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="226" mass="24957" checksum="2D8B2DBF2235D500" modified="2016-04-13" version="1" fragment="single">MALNKSRSLTPYHRRSSIPSQSPTDGHYPQAHRLVDINGQSIIRSVNSRLLGRPSSAVSAPSKGMGMQLGKSQRANQFLESLKDEGEVIVEDVRPSANPRRASAPPPTDPITLTTEEKLNVTLKRDGDVTTSFDSLTGDCTPSQFFVNWNSKQQEPDSSNRFNKASFSKASIDHPRLNSSCATVLRKQLHSNSFTATAGLKQQSETETGYQPNCVIDMFVQLFLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y986</accession>
    <name>A0A103Y986_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_016808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001903">
        <property type="protein sequence ID" value="KVI04866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y986"/>
    <dbReference type="STRING" id="59895.A0A103Y986"/>
    <dbReference type="Gramene" id="KVI04866">
        <property type="protein sequence ID" value="KVI04866"/>
        <property type="gene ID" value="Ccrd_016808"/>
    </dbReference>
    <dbReference type="OMA" id="VMHEISV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08301">
        <property type="entry name" value="alcohol_DH_plants"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001292">
        <property type="entry name" value="Alcohol dehydrogenase class-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF40">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="206"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="478"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="551" mass="60378" checksum="E3C09E11AC4A5301" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9R9</accession>
    <name>A0A103Y9R9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001889">
        <property type="protein sequence ID" value="KVI05109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9R9"/>
    <dbReference type="Gramene" id="KVI05109">
        <property type="protein sequence ID" value="KVI05109"/>
        <property type="gene ID" value="Ccrd_016562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="11081" checksum="F81E739A4B95C7AE" modified="2016-04-13" version="1">MEGIDVLVFNKGHRGLVVFQGFTFKFWRYENEYERRNNIQEIDGKESSIIELHIWCCRASHLLVRTILIIWTGALENSKVSMCSCSTMGVGGILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAF1</accession>
    <name>A0A103YAF1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAF1"/>
    <dbReference type="Gramene" id="KVI05482">
        <property type="protein sequence ID" value="KVI05482"/>
        <property type="gene ID" value="Ccrd_016151"/>
    </dbReference>
    <dbReference type="OMA" id="VLWSKFI"/>
    <dbReference type="OrthoDB" id="734536at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37206">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37206:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23368" checksum="8D65DBE9190604B5" modified="2016-04-13" version="1">MEDNEWEAIQPSSSATESDEEDVDAVVVTRPTTTGSSVFGPSNHEGLPVSPQPPQDDYLREPVPETPSSPSSYSSSSTATSTEIVDGELPQPPEVRNTLLKASFGILSSWALRIAYGIRTRTGFWSIASVAAIVAVMAYGRRWQRWRRLAEKENKDQLALLISRKDEKIKQLLLQIDRMNEALSAQQRVPVLRVVVDSPLVIGPRANWKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAL9</accession>
    <name>A0A103YAL9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAL9"/>
    <dbReference type="Gramene" id="KVI05589">
        <property type="protein sequence ID" value="KVI05589"/>
        <property type="gene ID" value="Ccrd_016087"/>
    </dbReference>
    <dbReference type="OMA" id="KMHERSS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37736">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37736:SF1">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47262" checksum="2FBAA291F3E4C30B" modified="2016-04-13" version="1">MASVTATSDVTDGPVLTLINKRIRNLRKKLNRVAQLEDSIAQGKSIIKNKEQEELLKTKPTIIAAVDELEKFRQSLSVAVDEEINLALQRRNVAASHNNDDDDVDNSSKAQTLDKEQQETEQPVLGVEDLLSLIYFASMFDVKSQSDFNSIMLTRTHERNCCLTYDYVTDDDAAVMLGERDLDLISMMGSLLISRPVDSSLSHQNALQRCIEHAKLWLSKSEQQIDSNSNVTYAALREKLTKIMGSDYFKITPEMKATADVAAEAAGNYSFQVPVQVEGSVSQYEQKQEDDVTDLQRSETYEDQSGPVEDFPKDEADGVEIPVHKEPIEAHGGNEEYKEQQASRRPYQNQRGGGRGGGGGGRRGYPNGRGARSGGRGGPYQNGRNQYYDQPGNYYPRNYYGGKGRGGGRGNGGNAYNHPGSGVEDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCR1</accession>
    <name>A0A103YCR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UV-B-induced protein At3g17800, chloroplastic-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001766">
        <property type="protein sequence ID" value="KVI06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCR1"/>
    <dbReference type="STRING" id="59895.A0A103YCR1"/>
    <dbReference type="Gramene" id="KVI06682">
        <property type="protein sequence ID" value="KVI06682"/>
        <property type="gene ID" value="Ccrd_014963"/>
    </dbReference>
    <dbReference type="OMA" id="FVDTRYH"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038925">
        <property type="entry name" value="At3g17800-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31808">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31808:SF4">
        <property type="entry name" value="LIGASE, PUTATIVE (DUF760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45311" checksum="C1AEFF2502895F76" modified="2016-04-13" version="1">METATALRSSFGTCIRPSNRNDLGRSRNGSIAFATVSNKRFPSFSHPRVGLRSVYFPSNKKRTAIKASLSSDSAGPTSPIAPLQLESPIGQLLSQILVSHPHLVPAAVEQQLEQLQTDRDAQEQNEEPAAPSTDLVLYRRIAEVKANERKKTLEEILYALVVQKFMDANVSLVPSVAPSPSASFKPVDAWPSQDEKLELLHSPEALEMIHNHLALILGNRVGDSTSVAEISKLRVGQVYAASVMYGYFLKRVDQRFQLEKTTKILPEDVEKEDINSNIQQQGSGDERVPNASSPQTHPEVSSWSGGGFTQAVKPSRLRNYVMSFDGESLQRYATIRSKEAVSIIEKHTEALFGRPEIVITAEGTVDSSKDEVIKISFGGLRRLVLEAVTFGSFLWDVESYVDSRYHFVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCW0</accession>
    <name>A0A103YCW0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001666">
        <property type="protein sequence ID" value="KVI06754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCW0"/>
    <dbReference type="STRING" id="59895.A0A103YCW0"/>
    <dbReference type="Gramene" id="KVI06754">
        <property type="protein sequence ID" value="KVI06754"/>
        <property type="gene ID" value="Ccrd_014890"/>
    </dbReference>
    <dbReference type="OMA" id="DAVMSPK"/>
    <dbReference type="OrthoDB" id="665906at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000006">
        <property type="entry name" value="ethylene-responsive transcription factor ERF014-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF231">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23002" checksum="D5A69C00FFA15186" modified="2016-04-13" version="1">MVKKEQEIQTESWKTSSSMISKKKYKGVRMRSWGSWVSEIRAPNQKTRIWLGSYSTAEAAARAYDAALLCLKGPTANLNFSHTQYNHDYSTPIMSPKSIQKIAAAAATVTDTVPSPSYSSSLSSSASTPPPTNPIEDEETLFSANDPLDGTLMSMVAPWYNFDSPTYNDVMLDTSFFEFDHSCSTTMEDVYEEEGGDDIYLWSFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDL3</accession>
    <name>A0A103YDL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001516">
        <property type="protein sequence ID" value="KVI07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDL3"/>
    <dbReference type="STRING" id="59895.A0A103YDL3"/>
    <dbReference type="Gramene" id="KVI07152">
        <property type="protein sequence ID" value="KVI07152"/>
        <property type="gene ID" value="Ccrd_014489"/>
    </dbReference>
    <dbReference type="OMA" id="IRNPVWE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398:SF4">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="442" mass="50079" checksum="3E9B48C785A92E23" modified="2016-04-13" version="1">MSIICGFPLLECVYCIACARWAWKRCLYTAGHDSETWGVAAAEEFEPVPRLCRYILAVYEDDLRCPLWEPPGGYGINPDWLILKRTYDDTHPQAPPYLLYLDHDHADIVLAIRGLNLANQKDYAVLLDNKLGQRKFDGGYVHNGLLKAAGVVLDAEYDTLKNLLEQYPNYTLTFTGHSLGSGIAALLAVVVVQNRHRLGNIDRKRIRCYSIAPARCMSLNLAVRYADIINSVDDFLPRTATPLEDIFKSVFCLPCLLCLRCIKDTFTSEEKKIKDPRRLYAPGRLYHIVERKPFRCGRFPPVVKTAVPVDGRFEHIVLSCNAISDHAIIWIEREAKRALDLMLEKDPLMEIPTEQKMERQQSLAKEHGEEHAAALKRAVKLSVPHAFLPSQYGTFHDSEGAFYVGESSTKHTPGVTWDDLIESLFEKDESGHVVFKKPHSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDR9</accession>
    <name>A0A103YDR9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001509">
        <property type="protein sequence ID" value="KVI07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDR9"/>
    <dbReference type="STRING" id="59895.A0A103YDR9"/>
    <dbReference type="Gramene" id="KVI07220">
        <property type="protein sequence ID" value="KVI07220"/>
        <property type="gene ID" value="Ccrd_014402"/>
    </dbReference>
    <dbReference type="OMA" id="IHLYRQG"/>
    <dbReference type="OrthoDB" id="658712at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35475">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35475:SF1">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="197" mass="22357" checksum="9F44817EBAF428E3" modified="2016-04-13" version="1">MVEIVETEETPRTTTATVKEEESRPLLDTSELKPRSKSVRTKVPEVEVHLYRRGEGPIDIFKSSLGGWDQDQLEVRDILDKYGLKSLYAYNTQSGRGVPIRFNGRNGRSILPYKDGSVIFIDGEPKDSLIKPITRILVGVAVLTAMIILVMKETPGWAKKLNFAGINFNVPPWVLACVVIVFTRLRKRTRDFFAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGF4</accession>
    <name>A0A103YGF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Like-Sm (LSM) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_012980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001099">
        <property type="protein sequence ID" value="KVI08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGF4"/>
    <dbReference type="STRING" id="59895.A0A103YGF4"/>
    <dbReference type="Gramene" id="KVI08645">
        <property type="protein sequence ID" value="KVI08645"/>
        <property type="gene ID" value="Ccrd_012980"/>
    </dbReference>
    <dbReference type="OMA" id="TAFRCHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009526">
        <property type="term" value="C:plastid envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010020">
        <property type="term" value="P:chloroplast fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056876">
        <property type="entry name" value="Msl2-3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057483">
        <property type="entry name" value="MSL2/3_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045042">
        <property type="entry name" value="YnaI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43634:SF2">
        <property type="entry name" value="LOW CONDUCTANCE MECHANOSENSITIVE CHANNEL YNAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43634">
        <property type="entry name" value="OW CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24956">
        <property type="entry name" value="Msl2-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25237">
        <property type="entry name" value="MSL2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive channel protein 2/3 transmembrane" evidence="12">
        <location>
            <begin position="146"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="10">
        <location>
            <begin position="277"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel protein 2/3 C-terminal" evidence="11">
        <location>
            <begin position="352"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="628" mass="69774" checksum="6A7B05269AFBF7B8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YII9</accession>
    <name>A0A103YII9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YII9"/>
    <dbReference type="STRING" id="59895.A0A103YII9"/>
    <dbReference type="Gramene" id="KVI09729">
        <property type="protein sequence ID" value="KVI09729"/>
        <property type="gene ID" value="Ccrd_011834"/>
    </dbReference>
    <dbReference type="OMA" id="WHKAERR"/>
    <dbReference type="OrthoDB" id="1584003at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032795">
        <property type="entry name" value="DUF3741-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46836">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46836:SF12">
        <property type="entry name" value="DUF3741-ASSOCIATED SEQUENCE MOTIF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14383">
        <property type="entry name" value="VARLMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="3">
        <location>
            <begin position="3"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="289"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49610" checksum="A28E2C20F685AFE4" modified="2016-04-13" version="1">MENSQNTPSVIAKLMGLDEMMPPWKQPISRQLRVLSDNYLQKSGSIGKRTRKDSQNNLLRSKKRANLRTNYSNEDISPKDLEQKSSNLDGIQGTESIKNGENASRSSFLVNPQTTFAWEAKKQLLERLKMTKVSQELRSSTQSSSLKSKPGSKFGGLIGISSKEGRTYKPVTKLPIFKLTNFSSNSTTKSLKITRSVDLKPSSVVNHMSTNIKKDNMVSNSSTPLSVSSNSDARTEMVGLSMQLQLLESESEENDMDPEMVTSSDDEKSCCTDENIKSVVSVGSKESRDFSYLLDVFDESGFEGGDVEIRFERWHSSECMGSPLVYERLEKKYGKQELWHKAERRLLFDRINAGMIEILRPLWSKPLRRKMTKNMWRRDAIEEELWILLASQENGVHDGVAQKAVGRGPWLGPEDELDSIVKEIETFLFDKLAAELICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIP6</accession>
    <name>A0A103YIP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001039">
        <property type="protein sequence ID" value="KVI09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIP6"/>
    <dbReference type="Gramene" id="KVI09844">
        <property type="protein sequence ID" value="KVI09844"/>
        <property type="gene ID" value="Ccrd_011755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="85" mass="9933" checksum="36383F28E62B02A7" modified="2016-04-13" version="1">MWVSLRIRGLATIEAVKGHRRWKLWSLTGYHRSSDNQRRGRRWWRLPETEAVEAVESHNRRYHGTIPVFQQCFRADSGGIGEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJQ4</accession>
    <name>A0A103YJQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Concanavalin A-like lectin/glucanase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_011165</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJQ4"/>
    <dbReference type="Gramene" id="KVI10415">
        <property type="protein sequence ID" value="KVI10415"/>
        <property type="gene ID" value="Ccrd_011165"/>
    </dbReference>
    <dbReference type="OMA" id="VALDWSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000141">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase VIII.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000372">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase VIII.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119790" evidence="17">
        <location>
            <begin position="28"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="360"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="67931" checksum="B7B17AF321E5984F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJV8</accession>
    <name>A0A103YJV8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_011091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001018">
        <property type="protein sequence ID" value="KVI10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJV8"/>
    <dbReference type="STRING" id="59895.A0A103YJV8"/>
    <dbReference type="Gramene" id="KVI10490">
        <property type="protein sequence ID" value="KVI10490"/>
        <property type="gene ID" value="Ccrd_011091"/>
    </dbReference>
    <dbReference type="OMA" id="CAEHEVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051758">
        <property type="entry name" value="ERF/AP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657:SF40">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="11">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="227" mass="25783" checksum="E3E6CEACA7CA67EB" modified="2016-04-13" version="1">MEQVADHGKNKGKQPWTPVQDSAFFFGTKIRKQESRFSFPFSLDDHNLQSSVNLEIPTPSKKRQMISFTPDNKEMDPRQPPGKLYRGVRQRQWGKWVGEIRLPRSRSRRWLGTFDTAVEAALAYDLEAFKLRGHQARLNFPHLLVNDQKQTITLPSSPSMSNPKSSQPSLFNNSYGSEPGSSKDQVLNGFEPNESLSEYGTEPPWETMEDGVSYASQAGYESVHEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNK0</accession>
    <name>A0A103YNK0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alcohol dehydrogenase class-III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutathione-dependent formaldehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000006">
        <property type="protein sequence ID" value="KVI12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNK0"/>
    <dbReference type="STRING" id="59895.A0A103YNK0"/>
    <dbReference type="Gramene" id="KVI12338">
        <property type="protein sequence ID" value="KVI12338"/>
        <property type="gene ID" value="Ccrd_009242"/>
    </dbReference>
    <dbReference type="OMA" id="RGRPTMC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF58">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="26562" checksum="C5A66E77F9859E5B" modified="2016-04-13" version="1">MMNDRKSRFSVKGTPIYHFMGTSTFSQYTVVHDVSVAKIDPQAPLEKVCLLGCGVPTGLGAVWNTAKVEAGSNVAIFGLGTVGLAVAEGAKAAGASRIIGIDIDPRKFDRAKQFGVTEFVNPKDHEKPIQQVLVDMTDGGVDYSFECIGNVSIMRAALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRTQVPQLEIKIDEYITHKLKLEEINKAFDLLHGGDCLRCVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118HPN5</accession>
    <name>A0A118HPN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007889">
        <property type="protein sequence ID" value="KVG61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118HPN5"/>
    <dbReference type="Gramene" id="KVG61248">
        <property type="protein sequence ID" value="KVG61248"/>
        <property type="gene ID" value="Ccrd_026326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG61248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="79" mass="9216" checksum="99B79A499CBB7172" modified="2016-04-13" version="1">MQKSLKPETYLMQKNVELPVRWLRRGEGRRSIGGWGRRRIPELVLQVLVCTKNLNVALWKSCLEYIFHRQACCVSSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I9D5</accession>
    <name>A0A118I9D5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007360">
        <property type="protein sequence ID" value="KVG94851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I9D5"/>
    <dbReference type="STRING" id="59895.A0A118I9D5"/>
    <dbReference type="Gramene" id="KVG94851">
        <property type="protein sequence ID" value="KVG94851"/>
        <property type="gene ID" value="Ccrd_026070"/>
    </dbReference>
    <dbReference type="OMA" id="CTEKVQS"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162">
        <property type="entry name" value="OS02G0192300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162:SF9">
        <property type="entry name" value="PHD FINGER PROTEIN EHD3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="384"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="387"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG94851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="61615" checksum="C16F31424DC15360" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSQ6</accession>
    <name>A0A118JSQ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
            <ecNumber evidence="4">1.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.193" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005327">
        <property type="protein sequence ID" value="KVH88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSQ6"/>
    <dbReference type="STRING" id="59895.A0A118JSQ6"/>
    <dbReference type="Gramene" id="KVH88882">
        <property type="protein sequence ID" value="KVH88882"/>
        <property type="gene ID" value="Ccrd_024889"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01284">
        <property type="entry name" value="Riboflavin_deaminase-reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.40:FF:000001">
        <property type="entry name" value="Swarming motility protein ybiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="521"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1090" mass="118832" checksum="0203883708118A97" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT40</accession>
    <name>A0A118JT40_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_008171</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005135">
        <property type="protein sequence ID" value="KVH89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT40"/>
    <dbReference type="STRING" id="59895.A0A118JT40"/>
    <dbReference type="Gramene" id="KVH89832">
        <property type="protein sequence ID" value="KVH89832"/>
        <property type="gene ID" value="Ccrd_008171"/>
    </dbReference>
    <dbReference type="OMA" id="RVQVMCS"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000017">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044813">
        <property type="entry name" value="ACP_chloroplastic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46153">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46153:SF20">
        <property type="entry name" value="ACYL CARRIER PROTEIN 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="14638" checksum="2D6380C5F61B082B" modified="2016-04-13" version="1">MASIAGSSSLMASLSCHKPNQALSRASNFNAVSLAINGKSFPSLKLHSAPSRLRVSCAAKPETVDKVCSIVRKQLALPEDSAVTGESKFSSLGADSLDTVEIVMGLEEEFGISVEEESAQTIATVQDAADLIEKLIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTU3</accession>
    <name>A0A118JTU3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A118JTU3"/>
    <dbReference type="STRING" id="59895.A0A118JTU3"/>
    <dbReference type="Gramene" id="KVH90941">
        <property type="protein sequence ID" value="KVH90941"/>
        <property type="gene ID" value="Ccrd_007078"/>
    </dbReference>
    <dbReference type="OMA" id="FPETYAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF99">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN ECT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="446"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1301" mass="143444" checksum="2DD997F71A593BB2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU96</accession>
    <name>A0A118JU96_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(+)-lariciresinol reductase</fullName>
            <ecNumber evidence="3">1.23.1.1</ecNumber>
            <ecNumber evidence="4">1.23.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">(+)-pinoresinol reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.23.1.1" evidence="3"/>
    <dbReference type="EC" id="1.23.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004913">
        <property type="protein sequence ID" value="KVH91661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU96"/>
    <dbReference type="STRING" id="59895.A0A118JU96"/>
    <dbReference type="Gramene" id="KVH91661">
        <property type="protein sequence ID" value="KVH91661"/>
        <property type="gene ID" value="Ccrd_006322"/>
    </dbReference>
    <dbReference type="OMA" id="EPSASFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010284">
        <property type="term" value="F:lariciresinol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010283">
        <property type="term" value="F:pinoresinol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902125">
        <property type="term" value="P:(+)-pinoresinol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902138">
        <property type="term" value="P:(-)-secoisolariciresinol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF47">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="14788" checksum="BAA6A68CFF7B6976" modified="2016-04-13" version="1">MRLKVLIIGGTGYIGKRLVKANIVVDVEKVQILLSFKKQGARLVIGSFNDHCSLVKAVKQVDVVICAISGRFLPSEFGMDPARMADAMEPGRVAFDDKMVVRKAIEDAGIPFMYRFLPSEFGIDPARMGEIMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUS2</accession>
    <name>A0A118JUS2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUS2"/>
    <dbReference type="STRING" id="59895.A0A118JUS2"/>
    <dbReference type="Gramene" id="KVH92934">
        <property type="protein sequence ID" value="KVH92934"/>
        <property type="gene ID" value="Ccrd_004971"/>
    </dbReference>
    <dbReference type="OMA" id="RYVNRKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16870" checksum="DFCC520E25EE2134" modified="2016-04-13" version="1">MLLKVIILGDSGYVNRKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNVMKSFDSLNNWREEFLIQASPSDPENFPFVLLGNKIDGNIPYFETSAKEGINVEAAFQCIATNALKTEPEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVU0</accession>
    <name>A0A118JVU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_003632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVU0"/>
    <dbReference type="STRING" id="59895.A0A118JVU0"/>
    <dbReference type="Gramene" id="KVH94314">
        <property type="protein sequence ID" value="KVH94314"/>
        <property type="gene ID" value="Ccrd_003632"/>
    </dbReference>
    <dbReference type="OMA" id="YYEIFAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="161"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="494"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH94314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="648" mass="73405" checksum="863E613E5F98B81D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX82</accession>
    <name>A0A118JX82_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004275">
        <property type="protein sequence ID" value="KVH96521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX82"/>
    <dbReference type="Gramene" id="KVH96521">
        <property type="protein sequence ID" value="KVH96521"/>
        <property type="gene ID" value="Ccrd_001389"/>
    </dbReference>
    <dbReference type="OMA" id="FDKWHLP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="19272" checksum="B0D8F032F2FC2A42" modified="2016-04-13" version="1">MAGGRFRELLKKYGKVALGVHFSVSAASISGLYVAIKNNVDVESALEKVRFKQLESILEKVGMGGLKEEVEGEASNIPQSNPEVKPRNRTAELAASSGGALALAVLCNKALFPVRVPITIALTPSIARNILFAYYNATIDMGSLGAPWSPLKEHLIVEHGTSTTKNRPTQDPFRKLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXI6</accession>
    <name>A0A118JXI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004342">
        <property type="protein sequence ID" value="KVH96262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXI6"/>
    <dbReference type="STRING" id="59895.A0A118JXI6"/>
    <dbReference type="Gramene" id="KVH96262">
        <property type="protein sequence ID" value="KVH96262"/>
        <property type="gene ID" value="Ccrd_001654"/>
    </dbReference>
    <dbReference type="OMA" id="YLMGFRG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="729"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="764"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="939"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127430" checksum="132FDF75B1C36409" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXY1</accession>
    <name>A0A118JXY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_000826</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="LEKV01003864">
        <property type="protein sequence ID" value="KVH97077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXY1"/>
    <dbReference type="STRING" id="59895.A0A118JXY1"/>
    <dbReference type="Gramene" id="KVH97077">
        <property type="protein sequence ID" value="KVH97077"/>
        <property type="gene ID" value="Ccrd_000826"/>
    </dbReference>
    <dbReference type="OMA" id="THIEIMT"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140936">
        <property type="term" value="F:histone H2B deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140852">
        <property type="term" value="F:histone ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009965">
        <property type="term" value="P:leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010162">
        <property type="term" value="P:seed dormancy process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000414">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="782"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="690"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH97077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="834" mass="95520" checksum="B41F8F432D89D412" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY09</accession>
    <name>A0A118JY09_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003848">
        <property type="protein sequence ID" value="KVH97212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY09"/>
    <dbReference type="STRING" id="59895.A0A118JY09"/>
    <dbReference type="Gramene" id="KVH97212">
        <property type="protein sequence ID" value="KVH97212"/>
        <property type="gene ID" value="Ccrd_000680"/>
    </dbReference>
    <dbReference type="OMA" id="FECKSIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="18785" checksum="31D8C2AE2901296E" modified="2016-04-13" version="1">MGTAVEAANKEATGSALTQKKPKVIFVLGGPGSGKGTQCANIVEHFGYTHLSAGDLLRAEIKSGSENGTMIQNMIKEGKIVPSEVTIKLLEKAISENENDKFLIDGFPRNEENRAAFESVTGIVPEFVLFFDCPEEEMEKRLLGRNQIDAAKPVGEVFEAVKALFTPVNDKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY53</accession>
    <name>A0A118JY53_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_023668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY53"/>
    <dbReference type="STRING" id="59895.A0A118JY53"/>
    <dbReference type="Gramene" id="KVH98122">
        <property type="protein sequence ID" value="KVH98122"/>
        <property type="gene ID" value="Ccrd_023668"/>
    </dbReference>
    <dbReference type="OMA" id="RMMSGHT"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="136"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH98122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="445" mass="49221" checksum="D828860830BAD586" modified="2016-04-13" version="1" fragment="single">CFTPIRSFSSHLAGDPSPADHFYFNNTGSIPPAKMITVPYLTALTTYFSYGLLFAFGQLRDFFRRFIDWWKAGNLQGYAPICLGLEDFYIRRLYLRIQDCFGRPISSPPDAWFDVVERISYDNNKTLKRTTKTSRCLNLGSYNYLGFAAADEYCTPRVIECLKKYSASTCSTRVEGGTTALHCELEDVVANFVRKPAALVTGMGYVTNSAILPVLIAKGGLIISDSLNHNSIVNGARAPSHLEKVLRELIADGQPRTHRPWKKIIVVVEGIYSMEGELCELPEIVSICKKYKAYVYLDEAHSIGAIGKTGRGVCELLGVDTADVDVMMGTFTKSFGSCGGYIAGSKELIQYLKYTCPAHIYATSISPPSAEQILSAIKKMGFEVLGDNDSPVMPIMLYNPAKIPAFSRECLKQKVISNVGDLVGIKYFPAESKMPQVEEARAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZN5</accession>
    <name>A0A118JZN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Leaf</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003506">
        <property type="protein sequence ID" value="KVH99474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZN5"/>
    <dbReference type="Gramene" id="KVH99474">
        <property type="protein sequence ID" value="KVH99474"/>
        <property type="gene ID" value="Ccrd_022292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="129" mass="15176" checksum="84F8853553600335" modified="2016-04-13" version="1">MPRSQINGNFIDKTFSIVANILLRIIPTTSREKEAFTYYXDVLRETNMIRHWDKKKKKSTLVEGKVWKTIPSVVYPRLMQPQMQQRGRSTTPRNQQHENFVLNYPLAGLGLKEWLGPKKCISFVFWIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K085</accession>
    <name>A0A118K085_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K085"/>
    <dbReference type="Gramene" id="KVI00375">
        <property type="protein sequence ID" value="KVI00375"/>
        <property type="gene ID" value="Ccrd_021392"/>
    </dbReference>
    <dbReference type="OMA" id="ACKHHGN"/>
    <dbReference type="OrthoDB" id="1854885at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001093">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g34400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF495">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="517"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="67623" checksum="7FE1444801919AFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0J3</accession>
    <name>A0A118K0J3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003061">
        <property type="protein sequence ID" value="KVI01515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0J3"/>
    <dbReference type="STRING" id="59895.A0A118K0J3"/>
    <dbReference type="Gramene" id="KVI01515">
        <property type="protein sequence ID" value="KVI01515"/>
        <property type="gene ID" value="Ccrd_020213"/>
    </dbReference>
    <dbReference type="OMA" id="EHNFASS"/>
    <dbReference type="OrthoDB" id="693960at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009867">
        <property type="term" value="P:jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF112">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 50-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="6">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="182" mass="20613" checksum="FF25D6385930D71B" modified="2016-04-13" version="1">MDGYEEMSKAYSYRSLDSPVDYDVPNHQSSELFDSFLVFDDWLNEDQASIVPEYPGHTPVYPSAAIEDGNHSIGSSSSSSHLQGNSSMFLLLGGIGIRQAQKGTKEKVAFKTKSQVEILDDGFKWRKYGKKMVKNSPNPRNYYRCSAQGCPVKKRVERDVEDARYVITTYEGVHNHERPSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0V3</accession>
    <name>A0A118K0V3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002672">
        <property type="protein sequence ID" value="KVI01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0V3"/>
    <dbReference type="STRING" id="59895.A0A118K0V3"/>
    <dbReference type="Gramene" id="KVI01922">
        <property type="protein sequence ID" value="KVI01922"/>
        <property type="gene ID" value="Ccrd_019801"/>
    </dbReference>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36516" checksum="A3EDA4D51978C1E8" modified="2016-04-13" version="1">MAAVPPVRGRELSNPPSDGISNLRFSHHSDHLLVSSWDKSVRLYDASENILRGEFIHGGAVLDCCFHDDNSGFSASADNTVRRLVFNYEREDVLGRHDAPVRCIEYSYATGQVITGSWDKTLKCWDPRGASAQERALVGTYAQPERVYSLSLVGNRLVVATAGRHVNVYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGIAPELLHQNHFCSPGYALSSVEGRVAMEFFDLSEAGQSKNYGTFATGGCDGFVNVWDGNNKKRLYQYTKYPTSIAALSFSRDGRLLAVASSYTFEEGDKPHEPDAIFVRSVNEVEVKPKPKVYPNPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K152</accession>
    <name>A0A118K152_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002665">
        <property type="protein sequence ID" value="KVI02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K152"/>
    <dbReference type="STRING" id="59895.A0A118K152"/>
    <dbReference type="Gramene" id="KVI02040">
        <property type="protein sequence ID" value="KVI02040"/>
        <property type="gene ID" value="Ccrd_019680"/>
    </dbReference>
    <dbReference type="OMA" id="SERYCFK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33271">
        <property type="entry name" value="OS04G0445200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33271:SF7">
        <property type="entry name" value="PLASTID TRANSCRIPTIONALLY ACTIVE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="2">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="180" mass="21196" checksum="685DFA5839BBC341" modified="2016-04-13" version="1">MEKRVSMFRDGVGGEVKKNRTQRRSSESRRAPFLPTKVQNSATMASLAMAPQLFSISKRNKAERKTSHSTHVRIRSMQRPLEEIYSIRVERNVSKERLAELEVSKWSTWKTGKCNVPWDWHVDQLVFIEEGEVRVVPEGSERHMSFVAGDLVRYPKWFEADLWFNGYYQERYSFRAYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K244</accession>
    <name>A0A118K244_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002331">
        <property type="protein sequence ID" value="KVI03783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K244"/>
    <dbReference type="STRING" id="59895.A0A118K244"/>
    <dbReference type="Gramene" id="KVI03783">
        <property type="protein sequence ID" value="KVI03783"/>
        <property type="gene ID" value="Ccrd_017921"/>
    </dbReference>
    <dbReference type="OMA" id="ELDTHCD"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="23576" checksum="B2623D24B3834482" modified="2016-04-13" version="1">MEEGEAGEEYLFKIVVIGDSAVGKSNLLSRFARDEFDLHSKATIGVEFQTQVVEIDGKEVKAQVWDTAGQERFRAVTSAYYRGAVGALIVYDISRRTTFESIKRWLGELNTHCDTAMATMLVGNKSDLENIRDVSVEEGKSLAEEEGLFFIETSALDSTNVTTAFEIVIRAIYDNVRRKVLNSDSYKSEVSLNRVSLVKDGNTKQNYCCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2E4</accession>
    <name>A0A118K2E4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_017437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the plant Proton pump-interactor protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002289">
        <property type="protein sequence ID" value="KVI04243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2E4"/>
    <dbReference type="STRING" id="59895.A0A118K2E4"/>
    <dbReference type="Gramene" id="KVI04243">
        <property type="protein sequence ID" value="KVI04243"/>
        <property type="gene ID" value="Ccrd_017437"/>
    </dbReference>
    <dbReference type="OMA" id="RINMEYL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055282">
        <property type="entry name" value="PPI1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32219:SF24">
        <property type="entry name" value="PROTON PUMP-INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32219">
        <property type="entry name" value="RNA-BINDING PROTEIN YLMH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="32083" checksum="9D58FD6BD1D52980" modified="2016-04-13" version="1">MWFSSCDMRIEWMTREIKNLGEVEPRLPVSSVPRTRTTGFVSLNDKKDGQTPDRKCCQKRMIKKDRINMEYLQQVQEELMCSKKSSCRTQELNDLIESMEHRIRHVNQNRADEMKMYREIRNVKETREMYNASEPDPPGYWYTKERLSKQDTDWNRSMQHRIHIRLDDIERIKRDLTGRKHRVTRLKSELERVRKSIGSLQKELEDVNSKRIKAYKRAYELGEQKRELKSSYDEYQSLITYANRLARKGDVVGLKQVCDTQTLVTIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2M2</accession>
    <name>A0A118K2M2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_017058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001957">
        <property type="protein sequence ID" value="KVI04622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2M2"/>
    <dbReference type="STRING" id="59895.A0A118K2M2"/>
    <dbReference type="Gramene" id="KVI04622">
        <property type="protein sequence ID" value="KVI04622"/>
        <property type="gene ID" value="Ccrd_017058"/>
    </dbReference>
    <dbReference type="OMA" id="YHHESSA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="93"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI04622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="433" mass="47659" checksum="A38DA06D4F6B401B" modified="2016-04-13" version="1">MVCSSHLRTVILQAGNIQKVAEGLVQFANFKSSLKTLPAATFSSVKIFPSIRKMMVDNSASANRGLITDTSPEKDNYGGYASGGWKSEDGKLSCGYSSFRGKRVSMEDFYDVKTCKINGQTVCLFGIFDGHGGSRAAEYLKENLFKNLMNHPKFLTNTRVAISKPINSNEFTGETYQQTDSDFLESGKDTFRDDGSTASTAVLVGNHLYVANVGDSRTVLSKAGKAIPLSDDHKPNRSDERKRIESAGGVVMWAGKMSCKNKDLISLGFDHGQMGFLDLHLFIGTWRVGGVLAMSRAFGNRMLKQFVVAEPEIQEQELDEEFELLVLASDGLWDVVPNEDAVSLALLEEEPESAARKLIETAFSRGSADNITCIVVRLYHHESSAATAPEFKPQPPKSQSETETQIQPENELETETEIESESESRSEETKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K306</accession>
    <name>A0A118K306_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphofructokinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K306"/>
    <dbReference type="STRING" id="59895.A0A118K306"/>
    <dbReference type="Gramene" id="KVI05207">
        <property type="protein sequence ID" value="KVI05207"/>
        <property type="gene ID" value="Ccrd_016526"/>
    </dbReference>
    <dbReference type="OMA" id="SHICDAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650:SF20">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="38811" checksum="9E6964E589800C0C" modified="2016-04-13" version="1">MDACKALKLDGLVDSQLISNLCTDALSAEKYYYFVRLMGQKTSHICDAVEARAKQEKYHGVILLPEGLIESIPEVYALLQEIHRFLRQGVSVDKISTQLSPWASALFAFLPSFIREELLLYPESDDSAQLSQIETEKLLAVLVEAEMNKRLKEGTYKGKKFTAICHFLGYQARGSLPSKFDCDYAYVLGHICYHSLAAGLNGYMATVTNLKDSLSKWRCGAAPITAMMAVKDHGRASGAMMIGKPAVHPATVDVRGKVLLRKNANKFLMDDVYRNPGPLQFDGPGADSRTVSLYIEDLDYMGRIKELNVYLDKVRSIVKPGCSQDILRAALSAMSSVTDILSVMSSSSNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3Y8</accession>
    <name>A0A118K3Y8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001741">
        <property type="protein sequence ID" value="KVI06706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3Y8"/>
    <dbReference type="STRING" id="59895.A0A118K3Y8"/>
    <dbReference type="Gramene" id="KVI06706">
        <property type="protein sequence ID" value="KVI06706"/>
        <property type="gene ID" value="Ccrd_014940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="154" mass="17659" checksum="6295FB9F2F2E3B7F" modified="2016-04-13" version="1">MELLMEEEELKVDGLSMGDFHSNQKENFELASDFNATDDKNNGFTQENQAEDSNAEEEYDDEEDEDAEETYSLRFKGETNPLALTEDDAFGVQAYECLEQPGHEYEALAAKKRKESLNYNHLGMPPVKKLRQEDYPGPSFEDLLAIITHGKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4W5</accession>
    <name>A0A118K4W5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001227">
        <property type="protein sequence ID" value="KVI08158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4W5"/>
    <dbReference type="STRING" id="59895.A0A118K4W5"/>
    <dbReference type="Gramene" id="KVI08158">
        <property type="protein sequence ID" value="KVI08158"/>
        <property type="gene ID" value="Ccrd_013471"/>
    </dbReference>
    <dbReference type="OMA" id="NIFQATY"/>
    <dbReference type="OrthoDB" id="1906601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040336">
        <property type="entry name" value="At1g61900-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059003">
        <property type="entry name" value="At1g61900_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043891">
        <property type="entry name" value="SPARK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33831">
        <property type="entry name" value="GPI-ANCHORED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33831:SF4">
        <property type="entry name" value="GPI-ANCHORED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26584">
        <property type="entry name" value="At1g61900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19160">
        <property type="entry name" value="SPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="SPARK" evidence="2">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="At1g61900-like C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="464" mass="49915" checksum="BFD4F6B00DF16877" modified="2016-04-13" version="1">MDCVKAAALLKGSLCLRLLLFIIWVSNFLDVIAEKLPPTSRLVSLPSSGIFEPIEISPSVLPHYPFPGKALPPMYPSFPKTYKPVLTGRCPFNFSSISSIMDKTASDCSQLLAPLVGNVICCPQFGSSLHIFQGHYTKNSDSLVLQNTTADDCFSDIMEVLASRGANGSVPAMCSMKSSNLTGGSCPVKDLNTFEKTVNTSKLLEACSVIDPLKECCRSVCQPAIVEAAFQVSSSQSVVGENMEAGISTHVDVLNDCKGVVYSWLSRKLPSEAADSSFRILAACKVNKVCPLEFKQPVEVIKACRNVAAPSPSCCSSLNSYIAGVQKQMLITNRQAIICASVFGSMLRKSGILTDVYELCDVDLKDFSLQAYGEEGCLLRSLPADVVYDNSSGFSFTCDLSDNIVAPWPSSSSMSSFSLCAPEMSLPALPTSETEYPGCNGYGVVLDVVLIIVFVLFIVPLNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K537</accession>
    <name>A0A118K537_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001112">
        <property type="protein sequence ID" value="KVI08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K537"/>
    <dbReference type="STRING" id="59895.A0A118K537"/>
    <dbReference type="Gramene" id="KVI08490">
        <property type="protein sequence ID" value="KVI08490"/>
        <property type="gene ID" value="Ccrd_013137"/>
    </dbReference>
    <dbReference type="OMA" id="MAPAIWP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000062">
        <property type="entry name" value="Nuclear transcription factor Y subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF106">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT C-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="16815" checksum="EDDF43E6576E9CA5" modified="2016-04-13" version="1">MKADEDVRMISAEAPIVFARACEMFILELTLRSWNHTEENKRRTLQKNDIAAAITRTDIFDFLVDIVPREDIKDEAMTSMPTVTVPVGGPSDTFPYYYMPAQQSLQSGTPGMISNKPMLDPALYAQQPPPYMAPAIWPQPPQQPQSPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K617</accession>
    <name>A0A118K617_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K617"/>
    <dbReference type="STRING" id="59895.A0A118K617"/>
    <dbReference type="Gramene" id="KVI09978">
        <property type="protein sequence ID" value="KVI09978"/>
        <property type="gene ID" value="Ccrd_011626"/>
    </dbReference>
    <dbReference type="OMA" id="HASFHEL"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23370" checksum="2F67D59523D95A33" modified="2016-04-13" version="1">MASPPTSLPVSNPQATTTTQTTSIATPALRSFISRLSSSIRQSFSQRRPWYELVDRSAFSRPVSLSDATSRVRKNFSYFRINYSALLAAVLAFSLLSHPFSLIILLCLLGAWLFLYLFRPSDQPLVMFGRTFSDRETLLILIVFTIIVVFLTSIGSLVISALMVGLAIVCVHGAFRDPEDLFLDDQDQATAGLLSFLGGATSSAAAAAPPAMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6I6</accession>
    <name>A0A118K6I6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_010873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001003">
        <property type="protein sequence ID" value="KVI10723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6I6"/>
    <dbReference type="STRING" id="59895.A0A118K6I6"/>
    <dbReference type="Gramene" id="KVI10723">
        <property type="protein sequence ID" value="KVI10723"/>
        <property type="gene ID" value="Ccrd_010873"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000783">
        <property type="entry name" value="Proline-rich receptor-like protein kinase PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000212">
        <property type="entry name" value="Proline-rich receptor-like protein kinase PERK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047117">
        <property type="entry name" value="PERK1-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982:SF47">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="229"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI10723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="511" mass="56447" checksum="A655B65797924977" modified="2016-04-13" version="1">MPSSHSQDSSKSLPSFKDSGSSSANKNNNKNGSLSSSANKHKSSSSDKSNNDNKKPQNKNKSNKKKHNDDKSSSPALPRSLSSSHFALYPPLNSSSSEKYGSSSYNINNVIITGAAIGAVLLLLLMIACTVCCCHRKKKRQRYDNNRNNPSEIKVDTNNGYYSTQHAGNQLHEHGDLHLKMPPQPHSNPRSSDQQGWVAAPPPPPLGMVGSNEKNVFTYDDLVAATKEFDSSLLLGQGGFGYVHKGVLPNGKEVAVKSLKLGSGQGEHEFQTEVETISRIHHRHLVSLVGYCIAGQQRMLVYEFIPNKTLEYHLHGEGCPFMDCSTRFKLALGAAKGFAYLHEDCNPRIVHRNIKAANILLDEHYEAKVVDFGLTKLSSEIITHVSTRVMGTFGYLAPEYASMGKLTEKSDVYSYGVVLLELITGRRPINRNSDEGSLIDWARPILMHASDGGSLEKMVDPRIKENYNREKMLRMVACAAACIRHSPRIRPKMSQIVRILEGKVSFGDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7D8</accession>
    <name>A0A118K7D8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7D8"/>
    <dbReference type="STRING" id="59895.A0A118K7D8"/>
    <dbReference type="Gramene" id="KVI12106">
        <property type="protein sequence ID" value="KVI12106"/>
        <property type="gene ID" value="Ccrd_009441"/>
    </dbReference>
    <dbReference type="OMA" id="HKEKPYG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044590">
        <property type="entry name" value="CML48/49/50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824:SF1">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML49-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="27228" checksum="CA3D36865FC49838" modified="2016-04-13" version="1">MAGYPQNPSGYNYGAPPPSQQYYSAAYGAAPPPYGQHQQSPYAHAVASPYGAPSYGAPLSSPFAALLPSTFPPGTDPNVIACFQMADLDGSGAVDDNELQRSLSAYNQSFSIRTVRLLMYHFTNNNTRKIGPKDFTQVFYSLQNWRANFEKFDRDRSGRIDALELREALASLGFSVSHFVLDLLVLKFDKTGGMNKAIEYDHFIEYVSITILGLTEKFKEKDTAYSGYATFSYEAFMLTVLPLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7E8</accession>
    <name>A0A118K7E8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Presenilin</fullName>
            <ecNumber evidence="10">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_009402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, APH1 and PEN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7E8"/>
    <dbReference type="STRING" id="59895.A0A118K7E8"/>
    <dbReference type="Gramene" id="KVI12163">
        <property type="protein sequence ID" value="KVI12163"/>
        <property type="gene ID" value="Ccrd_009402"/>
    </dbReference>
    <dbReference type="OMA" id="TTNLMMF"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000002">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF26">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="48434" checksum="6F228EAD4E19E86B" modified="2016-04-13" version="1">MDGSILESIGVEIIGVMSPVSICMLLVVLLVYSLSSFSSSSVEPIRTAANLVYLEAPSDSTSQKIEGSLLNALVFVILIAAVTFLLVLLYYYNFTNFLKNYMRFSAFFVLGVMGGSIFISIIRQFSIPIDAITCLILLFNFTVVGVLSIFAEGIPIPIVLRQVYMVLLGIIVAAWFTNLPEWTTWTLLVALALYDLVAVLAPGGPLKILVELASSRDDELPALVYEARPTVSRNPRGSSLGLLVGGVSSDSVELQVEMTPNRNNATDSRNGDTIEMVDSRDETEETSPLVPNLRDRMRSSSSASSEFSAAMGGTDRIRQTEIVEDEEDMSPLAAILGMANEREPQLRSREIGEEATRGIKLGLGDFVFYSVLVGRAAMYDLMTVYACYLAIISGLGCTLILLSVCRHALPALPISIALGIMFYFLTRVLMEPFVVGISTNLMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAL4</accession>
    <name>A0A124SAL4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_024810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005744">
        <property type="protein sequence ID" value="KVH87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAL4"/>
    <dbReference type="Gramene" id="KVH87880">
        <property type="protein sequence ID" value="KVH87880"/>
        <property type="gene ID" value="Ccrd_024810"/>
    </dbReference>
    <dbReference type="OMA" id="HSAIMAM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000404">
        <property type="entry name" value="RNA-binding protein with multiple splicing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000335">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="233"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="321" mass="35158" checksum="573BE4D6F988BF4F" modified="2016-04-13" version="1">MAAYYQPPPAGPHAAQYAYYQPPPPPPPPGAAQPPPIAVPQLQHQYHIHQQPPFGSYSTPLHTPPFQEEVRTLFIAGLPDDVSPREIYNLFREFPGYQSSHLRSPNATQTQPFGFAVFLDQQSALAALHALNGMVFDLEKGSTLYIDLAKSNSRSKRSRTDDERHGSEKRLKGPTSFSRGFPDPGVGSVHMHGMSNSAYNMIGYPSAQSHGSLDGRPESIAARSRNSSAPPCPTIFVANLGPSCSEQELTQIFSRCRGFLKLKMQGTYGTPVAFVDFQDTACSSEALNHLQGTVLYSSVSGEGMRLEFAKSRMGMRSKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBW8</accession>
    <name>A0A124SBW8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of the large LEUC/IIL1 subunit and the small LEUD (SSU1, SSU2 or SSU3) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004896">
        <property type="protein sequence ID" value="KVH91962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBW8"/>
    <dbReference type="STRING" id="59895.A0A124SBW8"/>
    <dbReference type="Gramene" id="KVH91962">
        <property type="protein sequence ID" value="KVH91962"/>
        <property type="gene ID" value="Ccrd_006011"/>
    </dbReference>
    <dbReference type="OMA" id="PKFYNER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019761">
        <property type="term" value="P:glucosinolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000007">
        <property type="entry name" value="Isopropylmalate/citramalate isomerase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF2">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="9">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="33553" checksum="481378BAB2F82130" modified="2016-04-13" version="1">MPAIYKEPRNQALVVILLHASIFKPLRLHITGTEFFLWFSNSSYAFFFLWFSISSSRGFRFLSVVCSSSRSRHHQPFASLATSNVFNATKQRSFKPLISQSIVSSTSPVTRRTSVVAAATANSSSSASSTSFHGLCYVVGDNIDTDQIIPAEYLTLVPSKPEEYKKLGSYALIGLPASYETRFVEPEEFQSKYKIIIAGDNFGCGSSREHAPVALGAAGVTAVVAESYARIFFRNSVATGEVYPLESEARVCEECKTGDVVTIELEQSLLINHTSGKEYKLKPIGDAGPVIEAGGIFAYARKAGMIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBY4</accession>
    <name>A0A124SBY4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_005871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004856">
        <property type="protein sequence ID" value="KVH92097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SBY4"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000008">
        <property type="entry name" value="Cytochrome P450 71D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000043">
        <property type="entry name" value="Cytochrome P450 99A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF9">
        <property type="entry name" value="PREMNASPIRODIENE OXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="971"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="13">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="13">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH92097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116193" checksum="CA012A7B63DCF46B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC21</accession>
    <name>A0A124SC21_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase, subunit VIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004819">
        <property type="protein sequence ID" value="KVH92410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC21"/>
    <dbReference type="STRING" id="59895.A0A124SC21"/>
    <dbReference type="Gramene" id="KVH92410">
        <property type="protein sequence ID" value="KVH92410"/>
        <property type="gene ID" value="Ccrd_005547"/>
    </dbReference>
    <dbReference type="OMA" id="HHHYDEP"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit Via"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11015" checksum="203A936E44D29086" modified="2016-04-13" version="1">MASAIVRSSLRAALRGVARPNPASKRSFSSGASADEEAREAAKWEKITYVGIAACSILAFVNLSKGHPHFDEPPPYPYLHIRNKEFPWGPDGLFEVKTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC95</accession>
    <name>A0A124SC95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004795">
        <property type="protein sequence ID" value="KVH93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC95"/>
    <dbReference type="STRING" id="59895.A0A124SC95"/>
    <dbReference type="Gramene" id="KVH93097">
        <property type="protein sequence ID" value="KVH93097"/>
        <property type="gene ID" value="Ccrd_004870"/>
    </dbReference>
    <dbReference type="OMA" id="KQPETDP"/>
    <dbReference type="OrthoDB" id="1931494at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF252">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="25918" checksum="B61DC03B04F09086" modified="2016-04-13" version="1">MARGSRTKAAAGGAIGTRETVMGQQHDDNEPRYRGVRKRPWGRFAAEIRDPWKKARVWLGTFDSAEDAARAYDAAAVSLRGPKAKTNFPSLALRLHETADHGTIDHTHHHHHHHQRSFYEFQHFNTNQSRPTTSNLSSTVESTSGPRPSNPPRERTQQPLKPSQFPPMDDDCHSNCDSSSSVVDDYYCDADLSSSSRKPLPFDLNLPPPLADVGFSSNPIDDSDDLFVTALCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCI1</accession>
    <name>A0A124SCI1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase (Class B)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_004088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APS1/VSP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004592">
        <property type="protein sequence ID" value="KVH93852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCI1"/>
    <dbReference type="Gramene" id="KVH93852">
        <property type="protein sequence ID" value="KVH93852"/>
        <property type="gene ID" value="Ccrd_004088"/>
    </dbReference>
    <dbReference type="OMA" id="DQWSDLW"/>
    <dbReference type="OrthoDB" id="59415at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07535">
        <property type="entry name" value="HAD_VSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010028">
        <property type="entry name" value="Acid_phosphatase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014403">
        <property type="entry name" value="APS1/VSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01675">
        <property type="entry name" value="plant-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284">
        <property type="entry name" value="ACID PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284:SF10">
        <property type="entry name" value="ACID PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002674">
        <property type="entry name" value="VSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176141" evidence="4">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH93852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="30080" checksum="ECE8EC9BA466ABF3" modified="2016-04-13" version="1">MDSGRFAVALLFLFLFSFATGSLSERLIRMPSGDRGASVYSGVLSSRKNELFCESWKFSIETNDVGVWYVVPEKCVSFVQEYMNGERYRSDSEVIADYALKHARTVNIAGDGKDAWIFDIDETLLSNMPYYVNHGYGSEVFDENSFNEWVDLAEAPALPASLRLYTELQQLGFKIFLLTGRSEDQRKSTDKNLQYAGFTNYEKLILRGTSDLGKPATLYKSEKRQELKDDGYRIHGSSGDQWSDLLGFAIGKRSFKLPNPLYYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEM9</accession>
    <name>A0A124SEM9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F1 complex, delta/epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003376">
        <property type="protein sequence ID" value="KVI00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEM9"/>
    <dbReference type="STRING" id="59895.A0A124SEM9"/>
    <dbReference type="Gramene" id="KVI00558">
        <property type="protein sequence ID" value="KVI00558"/>
        <property type="gene ID" value="Ccrd_021194"/>
    </dbReference>
    <dbReference type="OMA" id="GHVHDVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="78" mass="8264" checksum="A4A20065A147347C" modified="2016-04-13" version="1">MKSRNTSISSGFAFVHSNSYTNILAVEAVPLDQIDSAHIQKGLTEFTQKLSSASTELEKAEAQIGVDVHSALNSALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SES0</accession>
    <name>A0A124SES0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003155">
        <property type="protein sequence ID" value="KVI00961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SES0"/>
    <dbReference type="STRING" id="59895.A0A124SES0"/>
    <dbReference type="Gramene" id="KVI00961">
        <property type="protein sequence ID" value="KVI00961"/>
        <property type="gene ID" value="Ccrd_020773"/>
    </dbReference>
    <dbReference type="OMA" id="VEQDMVK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="381" mass="41962" checksum="EBFFB96C5F636706" modified="2016-04-13" version="1" fragment="single">MDDVSVVMVGPRKVWGTWEELILGGAVLRHGTGDWDVISSELRTRTACPYYFTPELENLKAEKAHCDHIEYDSSQTESPPLPLPKTKGIKIKTIHKEGLKDEFELSAGSFTQDLETNPQPKSHSPSLNSSQNVEIKLQVPESCMNTMIEPSQEKGGTIRKRRGKRKRKDGNWEAKEGIVESENLGSSSGVRRNETSTSGCGQTVRSSSADLQDGDSCRGRETDDLVGIFNSVTENQYALIARIGNCCIKSTRELFRDLFLLANNALVFYSKRTREYKSALTLRGIVTKKYKQLCSESGSSSSRPLSSMLCFSSMSSPPVRPRSIRARAPSKQVKVVVKFPTSGQMVGRHGYLKVSSNSDSSSLNPPEASQSNVELSGSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFL3</accession>
    <name>A0A124SFL3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002337">
        <property type="protein sequence ID" value="KVI03617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFL3"/>
    <dbReference type="STRING" id="59895.A0A124SFL3"/>
    <dbReference type="Gramene" id="KVI03617">
        <property type="protein sequence ID" value="KVI03617"/>
        <property type="gene ID" value="Ccrd_018074"/>
    </dbReference>
    <dbReference type="OMA" id="TRMMEYL"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.760:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015213402" description="Expansin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="8">
        <location>
            <begin position="49"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="9">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="257" mass="27831" checksum="1EC5A96B2A04F570" modified="2016-04-13" version="1">MAIVSGILFIIFSALSLADGRIPGNYAGGAWQGAHATFYGGSDASGTMGGACGYGNLYSQGYGVNTAALSTALFNKGLSCGACFEIKCADDPRWCHPGSPSITVTATNFCPPNYALPNDNGGWCNPPRTHFDLAMPMFLKIAEYRAGIVPVSYRRVPCRKAGGIRFTINGFRYFNLVLISNVAGAGDIQKVWIKGTKTNWMSMSRNWGQNWQSNAVLTGQPLSFRVTSSDRRTSTSWNIAPANWQFGKTYTGKNFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103PWC4</accession>
    <name>A0A103PWC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyphenol oxidase, central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_026458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="7">Binds 2 copper ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008233">
        <property type="protein sequence ID" value="KVG38257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103PWC4"/>
    <dbReference type="Gramene" id="KVG38257">
        <property type="protein sequence ID" value="KVG38257"/>
        <property type="gene ID" value="Ccrd_026458"/>
    </dbReference>
    <dbReference type="OMA" id="HIRTNAC"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016213">
        <property type="entry name" value="Polyphenol_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022740">
        <property type="entry name" value="Polyphenol_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022739">
        <property type="entry name" value="Polyphenol_oxidase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF123">
        <property type="entry name" value="CATECHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12142">
        <property type="entry name" value="PPO1_DWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12143">
        <property type="entry name" value="PPO1_KFDV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000290">
        <property type="entry name" value="PPO_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0186">Copper</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="cross-link" description="2'-(S-cysteinyl)-histidine (Cys-His)" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVG38257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="616" mass="69129" checksum="E68696984DB2D95D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X5S1</accession>
    <name>A0A103X5S1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_025450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01006381">
        <property type="protein sequence ID" value="KVH84539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X5S1"/>
    <dbReference type="STRING" id="59895.A0A103X5S1"/>
    <dbReference type="Gramene" id="KVH84539">
        <property type="protein sequence ID" value="KVH84539"/>
        <property type="gene ID" value="Ccrd_025450"/>
    </dbReference>
    <dbReference type="OMA" id="WAGSIDQ"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="13">
        <location>
            <begin position="113"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="14">
        <location>
            <begin position="418"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036417-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="526" mass="58952" checksum="420A96A72996BC39" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB40</accession>
    <name>A0A103XB40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribulose bisphosphate carboxylase small chain, domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006190">
        <property type="protein sequence ID" value="KVH87455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB40"/>
    <dbReference type="STRING" id="59895.A0A103XB40"/>
    <dbReference type="Gramene" id="KVH87455">
        <property type="protein sequence ID" value="KVH87455"/>
        <property type="gene ID" value="Ccrd_025304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="entry name" value="Ribulose bisphosphate carboxylase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024681">
        <property type="entry name" value="RuBisCO_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE SMALL CHAIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262:SF0">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE SMALL SUBUNIT, CHLOROPLASTIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="RuBisCO, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="5" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="2" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribulose bisphosphate carboxylase small subunit" evidence="6">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH87455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="20927" checksum="CCA9A401FB7677A8" modified="2016-04-13" version="1">MFAASSVVIRIFRMSGCICMGLNPNALKLFHETNRKTVSNGSRIHFMKKFETISYLPPLTDDSIAKEIDYMMKKGWVGYIFRENSRLPNYYDGRYWMLRKLPMFGCSDVSQVLNEMEYRKAYPNAYIRCLAFDMLSRLSVCLCYSDTCFPMKAFCSVSFLFDQTFSSLLNVFFFCHGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCM4</accession>
    <name>A0A103XCM4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_024392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01005511">
        <property type="protein sequence ID" value="KVH88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCM4"/>
    <dbReference type="STRING" id="59895.A0A103XCM4"/>
    <dbReference type="Gramene" id="KVH88218">
        <property type="protein sequence ID" value="KVH88218"/>
        <property type="gene ID" value="Ccrd_024392"/>
    </dbReference>
    <dbReference type="OMA" id="SCWTPDC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000480">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF103">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="861" mass="96462" checksum="CCEFD517A72C773D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDF2</accession>
    <name>A0A103XDF2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005346">
        <property type="protein sequence ID" value="KVH88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDF2"/>
    <dbReference type="STRING" id="59895.A0A103XDF2"/>
    <dbReference type="Gramene" id="KVH88710">
        <property type="protein sequence ID" value="KVH88710"/>
        <property type="gene ID" value="Ccrd_025982"/>
    </dbReference>
    <dbReference type="OMA" id="TCHERNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DYW" evidence="2">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15969" checksum="04353C6BE1AF38D3" modified="2016-04-13" version="1">MKEKGVVRTAGCSYIEHGHMIHRFLVNDQAHPESESESIYAKLDEVIKKIQKAVYVPNPEFVLHDVEEEVKESLVSKHNEKLAIAFGLLVCNDSKPLIITKNLRICGDCHNMAKFVSFVEKRKIIIRDTRRFHHFADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XET5</accession>
    <name>A0A103XET5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005224">
        <property type="protein sequence ID" value="KVH89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XET5"/>
    <dbReference type="STRING" id="59895.A0A103XET5"/>
    <dbReference type="Gramene" id="KVH89373">
        <property type="protein sequence ID" value="KVH89373"/>
        <property type="gene ID" value="Ccrd_008637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF8">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="112" mass="12610" checksum="2C156E74B760DDF1" modified="2016-04-13" version="1" fragment="single">ITRRDSTRFVSLEKHGGANSLKTSSQESYYHHAWEILVRWHDSNMLISTIPSNLWSHKTLVVLNFIGGYQMLNKLSLAHNRLQGSTPKSLGTVKSLQLLDLSHNNLSGEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF09</accession>
    <name>A0A103XF09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005205">
        <property type="protein sequence ID" value="KVH89525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF09"/>
    <dbReference type="STRING" id="59895.A0A103XF09"/>
    <dbReference type="Gramene" id="KVH89525">
        <property type="protein sequence ID" value="KVH89525"/>
        <property type="gene ID" value="Ccrd_008483"/>
    </dbReference>
    <dbReference type="OMA" id="YNTAICK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006502">
        <property type="entry name" value="PDDEXK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579:SF70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579">
        <property type="entry name" value="OS03G0796600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04720">
        <property type="entry name" value="PDDEXK_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="21052" checksum="4AC26DCB61D771C0" modified="2016-04-13" version="1">MGGATTRIPMSHRVLSPSYNYSAGDNSGDQPAVQLSGSIFGFLEEEATVFSFPESDRISDIQHDIEEEDETETKNPEKIEDKIKFWDTQHQNLHTTLFRTTTLESKIRNITKEVVAELEVVENVCSCSRPVSSGCRSCRMTEICRRLQNSGYNTAICKSKWKSSSDIPSDEERKRRIQRSRIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF61</accession>
    <name>A0A103XF61_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005199">
        <property type="protein sequence ID" value="KVH89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF61"/>
    <dbReference type="STRING" id="59895.A0A103XF61"/>
    <dbReference type="Gramene" id="KVH89558">
        <property type="protein sequence ID" value="KVH89558"/>
        <property type="gene ID" value="Ccrd_008451"/>
    </dbReference>
    <dbReference type="OMA" id="HNGPYLI"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044789">
        <property type="entry name" value="Put_A1-4-GlycosylTfrase_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46781">
        <property type="entry name" value="ALPHA 1,4-GLYCOSYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46781:SF5">
        <property type="entry name" value="ALPHA 1,4-GLYCOSYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="1">
        <location>
            <begin position="339"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="468" mass="53258" checksum="8E11593D334CDF86" modified="2016-04-13" version="1">MENKNINDKKRSFFAVLSVFLLLLISFNGASIFSIKIPYQENVTGDSGNLLSMSSSLSNLMYAVEEEIPSEISRTHLGKTVSGAGDSMSLNSVLHSMHDVQQEQQQKEQRISLVKEETPPVISNSHLPLLRKSHSLRLESEDFPSKKKRILELLTSMESSGGLRQGDFRARVKEFFSKNETSCKVRFFMTWISSLDSFSDKEFHSIETLFNTHPKGCLLIVSNSMDSSKGNQILRPFLDKGFRVTAISPDLNYLLKNTEAESWFSRIIKGDIDAGYVPFGQNLSNLLRLCLLYKYGGVYIDTDLIIMKSFSKLKNSIGAQTLDLGSKNWSRLNNAVMVFDKMHPLVYKFIEEFSLTFNGNKWGHNGPYLVSRVVSRLQGRPGYNFTILPPPAFYPVNWNRVRNLFRGPKNETDAKWLRGKLRQIRSQSYAVHLWNKQSRKLHIKEGSILRKILSDHCVFCNSSTNAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFX8</accession>
    <name>A0A103XFX8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005122">
        <property type="protein sequence ID" value="KVH89956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFX8"/>
    <dbReference type="STRING" id="59895.A0A103XFX8"/>
    <dbReference type="Gramene" id="KVH89956">
        <property type="protein sequence ID" value="KVH89956"/>
        <property type="gene ID" value="Ccrd_008050"/>
    </dbReference>
    <dbReference type="OMA" id="RANNPPE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF105">
        <property type="entry name" value="MPV17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="26554" checksum="5632DB1CF5E01F70" modified="2016-04-13" version="1">MLRIWRWYQNCLAVHPVKTQVISSGLIWGLGDVAAQAVTHATAAKKKTLFLSEEERQLQINWRRVITTSLFGMAFVGPIGHFWLVILSNLNNNFMYEGLDRFLRLRLLYQPNSLRFVATKVALDGIIFGPVDLFVFFTYMGLASGKNVDQVKEDVKRDFLPALVLEGGVWPIVQVGNFRFIPVRYQLLYVNLFCLLDSCFLSWLEQQQDAAWKQWFKSFPFKEHKNRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGG9</accession>
    <name>A0A103XGG9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005109">
        <property type="protein sequence ID" value="KVH90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGG9"/>
    <dbReference type="Gramene" id="KVH90289">
        <property type="protein sequence ID" value="KVH90289"/>
        <property type="gene ID" value="Ccrd_007711"/>
    </dbReference>
    <dbReference type="OMA" id="ATTLMHG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF4">
        <property type="entry name" value="OS08G0191900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="644"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="679"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="863" mass="96711" checksum="A85A2BF69CC0786A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH05</accession>
    <name>A0A103XH05_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005098">
        <property type="protein sequence ID" value="KVH90601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH05"/>
    <dbReference type="STRING" id="59895.A0A103XH05"/>
    <dbReference type="Gramene" id="KVH90601">
        <property type="protein sequence ID" value="KVH90601"/>
        <property type="gene ID" value="Ccrd_007375"/>
    </dbReference>
    <dbReference type="OMA" id="WLAFCNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF11">
        <property type="entry name" value="CASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="9">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="18051" checksum="3EE561595ECE2492" modified="2016-04-13" version="1">MEGDSTAISIVETPKERKGKAPLLAAPPGGSSSSTKPVVVQPAAAATKGDRYKRGLAVFDVVVRLAGVATALAAAIAMASTEQTLPFFTQFFQFQAGYDDLPAFTFFVVANAITATAGGAASIVYLAHNGNGDANWPAICQQFNDFCQKASGAVVASFLSVVVLMVLVVLSAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHH4</accession>
    <name>A0A103XHH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHH4"/>
    <dbReference type="Gramene" id="KVH90846">
        <property type="protein sequence ID" value="KVH90846"/>
        <property type="gene ID" value="Ccrd_007096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10193" checksum="6D776505B6873F08" modified="2016-04-13" version="1">MNFSALLMFGLDPVLYLTEHEINSFKSRPTVGRSWNRRSVKDMAANEPYLASSPVFILLKILSSNTIALWVQYISLLILAIFGKSRLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHQ3</accession>
    <name>A0A103XHQ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XHQ3"/>
    <dbReference type="Gramene" id="KVH90919">
        <property type="protein sequence ID" value="KVH90919"/>
        <property type="gene ID" value="Ccrd_007036"/>
    </dbReference>
    <dbReference type="OMA" id="CKNRMQL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009524">
        <property type="term" value="C:phragmoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007112">
        <property type="term" value="P:male meiosis cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055046">
        <property type="term" value="P:microgametogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080175">
        <property type="term" value="P:phragmoplast microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000052">
        <property type="entry name" value="Kinesin-like protein KIN-12F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="106"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1232"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144445" checksum="71E0AD8F980014A3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHT9</accession>
    <name>A0A103XHT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_007004</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005086">
        <property type="protein sequence ID" value="KVH90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XHT9"/>
    <dbReference type="Gramene" id="KVH90979">
        <property type="protein sequence ID" value="KVH90979"/>
        <property type="gene ID" value="Ccrd_007004"/>
    </dbReference>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000593">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001649">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="24">
        <location>
            <begin position="655"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="588"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="732"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="815"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVH90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1290" mass="149266" checksum="325BAC9715505054" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI56</accession>
    <name>A0A103XI56_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_006815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01005071">
        <property type="protein sequence ID" value="KVH91185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI56"/>
    <dbReference type="STRING" id="59895.A0A103XI56"/>
    <dbReference type="Gramene" id="KVH91185">
        <property type="protein sequence ID" value="KVH91185"/>
        <property type="gene ID" value="Ccrd_006815"/>
    </dbReference>
    <dbReference type="OMA" id="YVSIAKM"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF83">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH91185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="631" mass="72266" checksum="0B6D07B86A69CF20" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XII4</accession>
    <name>A0A103XII4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_006583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005031">
        <property type="protein sequence ID" value="KVH91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XII4"/>
    <dbReference type="Gramene" id="KVH91395">
        <property type="protein sequence ID" value="KVH91395"/>
        <property type="gene ID" value="Ccrd_006583"/>
    </dbReference>
    <dbReference type="OMA" id="NETFGWW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF145">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN, MFS TRANSPORTER SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="8">
        <location>
            <begin position="238"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="484" mass="53100" checksum="AD0CF4B17FBB9274" modified="2016-04-13" version="1" fragment="single">MDGISGDDMDTGVYGYEFRLPLLFNSIEIRIGNQSAAAQLLINGVGFRKVVWMVFWYFLIVFSDMDCPFHGGFPWFVWLRSSMASHSETRLISAFLLCLSSGCSITWFNTICFVLCIKNFPENWPLAVSLSVSFNGVTAALYNLIVTKISSDAKNGSYLILNAFLPLITSVAALIPILQQPCSRKNLHVENAADKEDAYTFGFLYLLAAESLSSISNQKSFGCRVFDKMIEKDRVTVIGEEHTVRMLVTRCDFWLYFVAYFCGGTIGLVYSNNLGQISQSRGYVSETRSLVTIYSTCSFFGRLISAGPDLVGGFYPSKTYTKRYTTTRTGWLALSLVPMPIAFLMLVLSGTESALSTATGLIGISSGFVFSAAVSITSELFGSKSSGINHNILITNIPLGSLLYGALGAVIYDNQIKSSAEVVVVGGSKVCMGRNCYNETFGWWGCVSLFGLAASFLLTNHKRVLIMWIPCQAFDVSTNGPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJT5</accession>
    <name>A0A103XJT5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004860">
        <property type="protein sequence ID" value="KVH92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJT5"/>
    <dbReference type="Gramene" id="KVH92086">
        <property type="protein sequence ID" value="KVH92086"/>
        <property type="gene ID" value="Ccrd_005884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053106">
        <property type="entry name" value="Plant_Male-Germline_Reg_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="21979" checksum="B3C478F9521E985E" modified="2016-04-13" version="1">MEHLQEHGPNKWNLLLSKGVLKRTEKSRRLRWLNNLQSNLKKGMFSGKRKNNWCLIYMQSKYGTNWVKIATYLPGRSVYHVKNIWYNHQKSMAQFLSLKKSLKEKQQIGREDTEHGLKKWNLLLSKGVLKHTTKSCRFWWFQHNLKKVHAQLGKIATYLSGRSVYHVKNVWYNYQKSMACLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJV2</accession>
    <name>A0A103XJV2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Presenilin</fullName>
            <ecNumber evidence="10">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, APH1 and PEN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004897">
        <property type="protein sequence ID" value="KVH91934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJV2"/>
    <dbReference type="STRING" id="59895.A0A103XJV2"/>
    <dbReference type="Gramene" id="KVH91934">
        <property type="protein sequence ID" value="KVH91934"/>
        <property type="gene ID" value="Ccrd_006022"/>
    </dbReference>
    <dbReference type="OMA" id="MYYQDID"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000002">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="45401" checksum="677EA9B0EEF7771E" modified="2016-04-13" version="1">MDQNPRPTGILHSLGEEIIRIITPVSICMFLVVILVSILDTNSSNFSSFNTIATIAYDESTSDSEWDKFKGALLNSLVFVAVVTVVTFLLVLLFYFRCTKFLKYYMGFSSFLVLGFMGGEIGLFLIQVFKIAIDSFTYVLLLFNFTIVGVLAVFMSKIPILVTQSYMVIIGVLTAYWFTMLPEWTTWVLLVAMALYDLAAVLLPGGPLRLLVELAISRDEDIPALVYEARPIVDPRRNSIVQRRIWRNVDLESTESSQNQRIIANAEEGQRIITNAEEGQRIIANAEEGHELTAPLIERIRDHGLVGENLGLEGIGLGSSGAIKLGLGDFIFYSVLVGRAAMYDYMTVYACYLAIIAGLGITLMLLALYQKALPALPVSVLLGVLFYVLTRVFLEEFIVQCSSNLLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJZ7</accession>
    <name>A0A103XJZ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004862">
        <property type="protein sequence ID" value="KVH92078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJZ7"/>
    <dbReference type="STRING" id="59895.A0A103XJZ7"/>
    <dbReference type="Gramene" id="KVH92078">
        <property type="protein sequence ID" value="KVH92078"/>
        <property type="gene ID" value="Ccrd_005895"/>
    </dbReference>
    <dbReference type="OMA" id="CCTTPIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF53">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="475" mass="50830" checksum="40D07CECA65B76C2" modified="2016-04-13" version="1">MAVVFVSPTKMLSSLSRRQYDSYRYSSTTKLHASPRSLIPRFPNLRLNNLYTRCSITNTEVFNDIITEEVCHDSSSDASNCSVPILHLNAEIHDTESANLLVEGTFVDMILTTLPILSEEEQDVIAAMPAHPAGLYALYASCLAGNLVEQLWNFAWPAAIALLHPSLLPVAVMGFCTKVAIIAGGPLVGKLMDLFPRVPAYNFLTTVQLAGSNRPIALAQANATLSRIDLLCEIAGASLFGILLSKYETVTCLKLALSSGVLDRAKCPQTCCRTFSAGPVPHVDNLVDVSINAIKNGWDEYMKQPVLPASLAYVLLCFNVVLAPGLSPSLIGGFSCLCALMGVGATFMSAQMVKKLGILKAGAAGLILQASLLTMAVAVYWSGALSQHTALLFFLGFIILQTGIPPSKANLIGATEVSIASLAESIILGVVIIANDISHFGFLAMLSLLSVVGAAWLFCRWLANPTDVQRSLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK03</accession>
    <name>A0A103XK03_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004848">
        <property type="protein sequence ID" value="KVH92130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK03"/>
    <dbReference type="Gramene" id="KVH92130">
        <property type="protein sequence ID" value="KVH92130"/>
        <property type="gene ID" value="Ccrd_005839"/>
    </dbReference>
    <dbReference type="OMA" id="AWYQHNS"/>
    <dbReference type="OrthoDB" id="1880786at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34665">
        <property type="entry name" value="DUF3741 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34665:SF4">
        <property type="entry name" value="DUF3741 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="201" mass="23305" checksum="072A86CC6498069E" modified="2016-04-13" version="1">MVVQENQKENKDQHAIMKAAAWAWYERGSWFEHKSVQESDYRRKRDYTPRPSRYKLEAIQKPQKETRESQSCGDGPSLDTEHVSASKQPQNQQCYVPVDTEHVDKSLLDKYEIERISKELDCYLESSSVEHRRRSVDGGDHGGRHRRTVALSEGTKSKSKSKKNKGFWARRRIVCGSSRDDVVETSNLLIGGRRRPKENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKY3</accession>
    <name>A0A103XKY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein family UPF0121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004812">
        <property type="protein sequence ID" value="KVH92595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKY3"/>
    <dbReference type="STRING" id="59895.A0A103XKY3"/>
    <dbReference type="Gramene" id="KVH92595">
        <property type="protein sequence ID" value="KVH92595"/>
        <property type="gene ID" value="Ccrd_005365"/>
    </dbReference>
    <dbReference type="OMA" id="WSKIGRT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="33301" checksum="6A398DF8AFBFA4BA" modified="2016-04-13" version="1">MGEEQDPQRLKKIAAAAYDYDNDSRWADYWSNVLIPPHMASRSDVITHFKHKFYQRYIDPDLVVEPMTTNSTSQSARSSTSSSSSGSEHRPPRNSAYRLSFMGTACSSLYSLYSLYGKPRAWNLQEVQVWLQSVIATKDFIYFIYCLTFVTSNLRLTFALLPIVYRSLEHSAKFTRRNFSRSSFYRKYLDEPCVWVESNATMLSILSSQAEIGIGFLLIISLLSSQRNIIQTFMYWQLLKLMYHAPVSAGYHQSVWSKIGRTVTPLIHRYAPFLNSPISAIQRWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL80</accession>
    <name>A0A103XL80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XL80"/>
    <dbReference type="Gramene" id="KVH92794">
        <property type="protein sequence ID" value="KVH92794"/>
        <property type="gene ID" value="Ccrd_005146"/>
    </dbReference>
    <dbReference type="OMA" id="KAIIHVD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
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</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
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                <person name="Scaglione D."/>
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                <person name="Portis E."/>
                <person name="Beitel C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304:SF75">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="202" mass="21781" checksum="0ABC7AF70CD4AFFC" modified="2016-04-13" version="1">MSCNGCRVLRKGCNDNCILRHSLHGICTPQAQANATVFVAKFFGRAGLMSFLASVPESQRPALFQSLLFEACGRTVNPVNGAVGLLWTGNWHVCQSAVETVLRGGSVRAMPELFSVGSTPENDDTSEAINSNFDVSKLRPQDLNLGLSSSGLDDEMRSGRHSDRRTTEKRRAVSPSDASETTTLESGLGSACSETKLLRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMP3</accession>
    <name>A0A103XMP3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">very-long-chain 3-oxoacyl-CoA synthase</fullName>
            <ecNumber evidence="3">2.3.1.199</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_004472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004762">
        <property type="protein sequence ID" value="KVH93478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMP3"/>
    <dbReference type="STRING" id="59895.A0A103XMP3"/>
    <dbReference type="Gramene" id="KVH93478">
        <property type="protein sequence ID" value="KVH93478"/>
        <property type="gene ID" value="Ccrd_004472"/>
    </dbReference>
    <dbReference type="OMA" id="WIFCFPP"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH93478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="31331" checksum="316EB73AA1947E32" modified="2016-04-13" version="1">MEDLYSNLHYWLVDHPTITHFQWKPNQTWGASPLFLSLTVLAYLLLTFVLRRASLPTLNSTFLRLISALHNLILLILSLIMAVGCSLSALSQMPNHRWIFCFPPNQTPPRGPVFFWAQIFYFSKLLEFIDTLLIILSGSNRRLSFLHVYHHAVVVVMCYLWLSTSQSLLPVALVTNASVHVLMYAYYLLCALGGRPWWKVLVTNCQIIQFVFSFMVSGLMLYYHFTGSGCSGFSGWCFNAVFNASLLALFVNFHFKNYAKRKKANRNTKSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNH7</accession>
    <name>A0A103XNH7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol polyphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004585">
        <property type="protein sequence ID" value="KVH93930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNH7"/>
    <dbReference type="STRING" id="59895.A0A103XNH7"/>
    <dbReference type="Gramene" id="KVH93930">
        <property type="protein sequence ID" value="KVH93930"/>
        <property type="gene ID" value="Ccrd_004025"/>
    </dbReference>
    <dbReference type="OMA" id="EDHMTRA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045849">
        <property type="entry name" value="IP5P_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666:SF15">
        <property type="entry name" value="TYPE I INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="512" mass="57795" checksum="46A125AAD2FDC201" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNX2</accession>
    <name>A0A103XNX2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like cysteine/serine peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004560">
        <property type="protein sequence ID" value="KVH94251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNX2"/>
    <dbReference type="STRING" id="59895.A0A103XNX2"/>
    <dbReference type="Gramene" id="KVH94251">
        <property type="protein sequence ID" value="KVH94251"/>
        <property type="gene ID" value="Ccrd_003719"/>
    </dbReference>
    <dbReference type="OMA" id="RICHDAN"/>
    <dbReference type="OrthoDB" id="1925372at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35729:SF4">
        <property type="entry name" value="PEPTIDASE S1, PA CLAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35729">
        <property type="entry name" value="T1B9.12 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="522" mass="56995" checksum="AB15721A1DD99788" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQD6</accession>
    <name>A0A103XQD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004475">
        <property type="protein sequence ID" value="KVH94988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQD6"/>
    <dbReference type="Gramene" id="KVH94988">
        <property type="protein sequence ID" value="KVH94988"/>
        <property type="gene ID" value="Ccrd_002944"/>
    </dbReference>
    <dbReference type="OMA" id="EFIKLQY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050404">
        <property type="term" value="F:zeatin O-beta-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016138">
        <property type="term" value="P:glycoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000238">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044:SF23">
        <property type="entry name" value="ANTHOCYANIDIN 3-O-GLUCOSYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH94988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="51415" checksum="9CE708E7C1402063" modified="2016-04-13" version="1">MASEVVVVMVPFVAQGHLNQLLHLSGLLSSYNLPIHFLCSATNTRQARHRLHGWNPNNLIHFHQLPDPEFTSPPPDPNSTTQFPTHLQPSFNSSLHLRRPVADIIRSLSHTATRVAVVHDSLMSYVVQDVKSIPNAETYIFRALSIFYVFCFQWEKLGRKLPFETHLLHRLPMSAESMTQEFMEFIKLQYSHQTIHVGNLYDSSRVIEGKFLELLEKDSINGKNHWAVGPFNPVDIQSEISDSCRRRHNCLQWLDKQPEKSVVFVSFGTTTTFTEEQIGELAVGLENSDQRFLWVLRDADKGDVFMNDGGRRVVLPEGFEERVAERGLVVRDWAPQLEILGHRSTGGFVSHCGWNSSMEAMTAGVAIAAWPLHSDQPRNAFLMADVLGVALMMKDWSCRDELFTSVMVEKVIRKLMDSEEGEAIRQRAAELGGELRRSMAEGGVTLLKQHAFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRF9</accession>
    <name>A0A103XRF9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily domain, general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004385">
        <property type="protein sequence ID" value="KVH95507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRF9"/>
    <dbReference type="STRING" id="59895.A0A103XRF9"/>
    <dbReference type="Gramene" id="KVH95507">
        <property type="protein sequence ID" value="KVH95507"/>
        <property type="gene ID" value="Ccrd_002420"/>
    </dbReference>
    <dbReference type="OMA" id="DSTTICI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67420" checksum="09F4B31F68B11CA7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRM1</accession>
    <name>A0A103XRM1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRM1"/>
    <dbReference type="STRING" id="59895.A0A103XRM1"/>
    <dbReference type="Gramene" id="KVH95615">
        <property type="protein sequence ID" value="KVH95615"/>
        <property type="gene ID" value="Ccrd_002289"/>
    </dbReference>
    <dbReference type="OMA" id="SHVWIEI"/>
    <dbReference type="OrthoDB" id="1854110at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050354">
        <property type="entry name" value="F-box/kelch-repeat_ARATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24414:SF44">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24414">
        <property type="entry name" value="F-BOX/KELCH-REPEAT PROTEIN SKIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="369" mass="40990" checksum="C3E22BEF99F8A598" modified="2016-04-13" version="1">MDTCNEQLPIHGDVLEAVLSHLPLIRLLPASRVSKSWNAAVSSALLVSNNTKPWLIIHTQNSRHPYPTTTHAYDPASNVWIQILHPPIHYVSTLRSSQSNLLYMLSQSKLSLSFDPLHLTWHHAAGPKVSRIDPVVAVVGGHVVVAGGAYDFEDDPLAVEVYDLRSQRWTKSDPMPESFNQSASSLWLSVASGDSHLFVMEKSSGVTHSFNPNNDTWSGPYDMRPDDRVFYSVIGFSDDKLVVIGMLGDAEDVDGIKLWEVNCESFEFEEIGEMPASLVENLKSQNLQISSIDVSMGGNMAYIYISSRPEEVIVCEFIDGGGCRWCSVVNTVANGWSVMDKLAFTCSKVGMEELQRATRSESRRFVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSI1</accession>
    <name>A0A103XSI1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_001842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004362">
        <property type="protein sequence ID" value="KVH96064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSI1"/>
    <dbReference type="STRING" id="59895.A0A103XSI1"/>
    <dbReference type="Gramene" id="KVH96064">
        <property type="protein sequence ID" value="KVH96064"/>
        <property type="gene ID" value="Ccrd_001842"/>
    </dbReference>
    <dbReference type="OMA" id="VTFITTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF4">
        <property type="entry name" value="POTASSIUM TRANSPORTER 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="101"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="252"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="380"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="13">
        <location>
            <begin position="583"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH96064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="773" mass="86987" checksum="B946894CE6BE4857" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSL8</accession>
    <name>A0A103XSL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSL8"/>
    <dbReference type="Gramene" id="KVH96136">
        <property type="protein sequence ID" value="KVH96136"/>
        <property type="gene ID" value="Ccrd_001780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8436" checksum="06072BAFEF0EBCE4" modified="2016-04-13" version="1" fragment="single">MSREDFLVNSMHLSSSNSLILYQTFFGNKKTHWQKGRRIIRKALYIRQWRRALLQGGDCEVLAVGLGVVGSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTT3</accession>
    <name>A0A103XTT3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004240">
        <property type="protein sequence ID" value="KVH96719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTT3"/>
    <dbReference type="STRING" id="59895.A0A103XTT3"/>
    <dbReference type="Gramene" id="KVH96719">
        <property type="protein sequence ID" value="KVH96719"/>
        <property type="gene ID" value="Ccrd_001188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="13525" checksum="C66251BE7906625B" modified="2016-04-13" version="1">MASARRWRMTVVQDGAGSNRRHTSRQHLSDGDSCLAGDRQPLYIAKTKNLITITEIGIIPEVIVLTWKNRATKIDHHQTSRLIGTGSFGCGTAIVEGEDFISENITYEAGVRRSGSKQWKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTT5</accession>
    <name>A0A103XTT5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004206">
        <property type="protein sequence ID" value="KVH96770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XTT5"/>
    <dbReference type="Gramene" id="KVH96770">
        <property type="protein sequence ID" value="KVH96770"/>
        <property type="gene ID" value="Ccrd_001139"/>
    </dbReference>
    <dbReference type="OMA" id="PIRIMLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF14">
        <property type="entry name" value="PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12190" checksum="D8E0F022FB412996" modified="2016-04-13" version="1" fragment="single">EDCSITQQLGVTCLAGYAAGSVGSIISNPTDNIVXSLNNKKVGSLKLVVKKIGLRNLFARSLPIRIMLMGPVVTLQWLFYDTIKVLSGLPTSGHIRSEVEDTGAKIQIVHDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWJ1</accession>
    <name>A0A103XWJ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWJ1"/>
    <dbReference type="STRING" id="59895.A0A103XWJ1"/>
    <dbReference type="Gramene" id="KVH98192">
        <property type="protein sequence ID" value="KVH98192"/>
        <property type="gene ID" value="Ccrd_023597"/>
    </dbReference>
    <dbReference type="OMA" id="QWPQPHS"/>
    <dbReference type="OrthoDB" id="766467at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026182">
        <property type="entry name" value="ANAPC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37771">
        <property type="entry name" value="OS02G0593400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37771:SF2">
        <property type="entry name" value="OS02G0593400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15243">
        <property type="entry name" value="ANAPC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="11365" checksum="ED67E1C6A7F2459C" modified="2016-04-13" version="1">MLQFPAFMTQYPTSTRIIPTSLLLPPQWPQPHSEELLLAIEESEFEEKYNDIRKINSNVIVIGKTSVENDKEDFENDADEDEADNAEESEGDEFEQETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWR1</accession>
    <name>A0A103XWR1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWR1"/>
    <dbReference type="STRING" id="59895.A0A103XWR1"/>
    <dbReference type="Gramene" id="KVH98333">
        <property type="protein sequence ID" value="KVH98333"/>
        <property type="gene ID" value="Ccrd_023448"/>
    </dbReference>
    <dbReference type="OMA" id="REDNTQF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043452">
        <property type="entry name" value="BZIP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952:SF446">
        <property type="entry name" value="ABSCISIC ACID-INSENSITIVE 5-LIKE PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952">
        <property type="entry name" value="CAMP-RESPONSE ELEMENT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="41265" checksum="FD0DE668D1D10258" modified="2016-04-13" version="1">MNFKNYGNQPPAAEVGGGGSGRPPGNFNLARQGSIYSLTFDELQTTMGSIGKDFGSMNMDELLKSIWNAEEVQTTVNTTTNGGQDGGGGGGGGGDGGANIQRQGSLTLPRTISQKTVDEVWKDISKEFSNGFGQPHLPQRQQTLGEMTLEEFLVKAGVVREEPQLDSKSNDNDLFSSLTNSQNNSSFGAIGFQPAASRNVNRIPENSSNQIAFQSTNLPLSVNGVRSTQQHPQQNHQQQLFQKQPNLSYGAPMASKQMGSPVIRNGIMGLSDSSMNGNLVSSGMLQGGMGGMVGLGATGGVTVAVGSPVFSSDGIGKTNGDTSSVSPAPYEFSGVVRGRKTGYGDDEHAARSQTTLSEKDTVWTVVKNLIKRSRSVRHLAFTRVVSVHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXB9</accession>
    <name>A0A103XXB9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BYPASS-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ROH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003783">
        <property type="protein sequence ID" value="KVH98616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXB9"/>
    <dbReference type="STRING" id="59895.A0A103XXB9"/>
    <dbReference type="Gramene" id="KVH98616">
        <property type="protein sequence ID" value="KVH98616"/>
        <property type="gene ID" value="Ccrd_023165"/>
    </dbReference>
    <dbReference type="OMA" id="QVRLWQK"/>
    <dbReference type="OrthoDB" id="1878996at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008511">
        <property type="entry name" value="ROH1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31509">
        <property type="entry name" value="BPS1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05633">
        <property type="entry name" value="ROH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44786" checksum="96C2F34008319C2E" modified="2016-04-13" version="1">MRTDYQGSSSPNFTSFGRSILGMKHDPMVHSIDHENFPSQDKEIEAFQRQVTQRFLDLASVDSNELLSVSWISNLLDVFLCCQEEFKAILFNNKSALSKQPMDKLVSDYFERSVKGLDVCNAIRDGIEQIRQWQKQLEIVLCALDNQKSLGEGQIRRAKKALIDLAIGMLDDKESSSTNLSHRNRSFGRYQKDSQRHKSLKHFRSLSWSVSRSWSASKQLHAIGYNIVPPKTNEIIATNGLSMAVYTMSYVFLFVMWALVAAIPCQDRGLQSHFNVPKNFIWGAPILSLHERILDESKKRERRNTCGLLKEIHGIEKSARYMNELTDSVQFPFGEEKEQEVKKRVEELRIVYRDLKNGLDPLEKQVRDVFHRIVRSRTEGLDSIARGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0C8</accession>
    <name>A0A103Y0C8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003396">
        <property type="protein sequence ID" value="KVI00206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0C8"/>
    <dbReference type="STRING" id="59895.A0A103Y0C8"/>
    <dbReference type="Gramene" id="KVI00206">
        <property type="protein sequence ID" value="KVI00206"/>
        <property type="gene ID" value="Ccrd_021531"/>
    </dbReference>
    <dbReference type="OMA" id="QTQLGHP"/>
    <dbReference type="OrthoDB" id="784295at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46327">
        <property type="entry name" value="F16F4.11 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46327:SF9">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="70"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="41720" checksum="DFCFF86615FA0433" modified="2016-04-13" version="1">MNLMNRIDDEPSLGFMETKILNPSTSYLSFGKGKADDNLNDHNISDEDEPSFMEDDNSNKGRKGSSPWQRMKWSDSRVRLLIQVVACVGDDGTLDGGSSRKSVCLQKKGKWKTVSKIMVTKGCQVSPQQCEDKFNDLNKRYKRLNDILGRGTSCRVVENPSLMESMPRLSAKTKEDVKKILNSKHLFYPEMCAYHNGQRIPNCTELDLMQVRETPVIGQCSKENNRSSDEGEDSDGSDDDDDDDSDHEDDEHKNGGEDGHLERGNSRFRDEINEVFEDPNNSKLQKKEWVKKRMLQLQEQRIGIEAEAFEMEKRRFKWQRFCDRKDRELEISRLENERSMLENERMALQLKHREHVVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0W3</accession>
    <name>A0A103Y0W3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003388">
        <property type="protein sequence ID" value="KVI00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0W3"/>
    <dbReference type="STRING" id="59895.A0A103Y0W3"/>
    <dbReference type="Gramene" id="KVI00472">
        <property type="protein sequence ID" value="KVI00472"/>
        <property type="gene ID" value="Ccrd_021301"/>
    </dbReference>
    <dbReference type="OMA" id="SEIFTHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="461" mass="51793" checksum="1FAE34280FCDD046" modified="2016-04-13" version="1">MAVLMPRIIQAKQILRRSLSNGSRNTYMAIPKGYFAVYVGEQEKKRFVVPVSLLSQPAFQELLYKAEEEFGYNHRMGGLTIPCSKDIFTDLASPFSSFISLYNKADGALLRKMAVLMPRIIQAKQILRRSLSNGSRNTYMAIPKGYFAVYVGEQEKKRFVVPVSLLSQPAFQELLYQAEEEFGYNHRMGGLTITCSEDIFTDLASLKPPISPLTGVARPGMKNKADCALLKTMAILMPRILQAKQILRRSLSNGSSNTYMAIPKGHFAVYVGEQEKKRFVVPLSLLSQPAFQELLYKAEEEFGYNHPMGGLTIPCSEDIFIDLASPIDGYKPHAWDHGVGRQNHVILHELCLYDKAEGALLRKMAILMPRIIQAKQILRRSLSNGSSNTYMAIPKGYFAVYVGKQEKKRFVVPVSLLSQPAFQELLYQAEEEFGYNHRMGGLTIPCSEDMFTDLASRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1T6</accession>
    <name>A0A103Y1T6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ccrd_020786</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 20">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003160">
        <property type="protein sequence ID" value="KVI00953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y1T6"/>
    <dbReference type="Gramene" id="KVI00953">
        <property type="protein sequence ID" value="KVI00953"/>
        <property type="gene ID" value="Ccrd_020786"/>
    </dbReference>
    <dbReference type="OMA" id="KETTHFE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF72">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RFK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malectin" evidence="23">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="22">
        <location>
            <begin position="249"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KVI00953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="519" mass="57971" checksum="1059407ACA3CFF4B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2V3</accession>
    <name>A0A103Y2V3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003073">
        <property type="protein sequence ID" value="KVI01504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2V3"/>
    <dbReference type="Gramene" id="KVI01504">
        <property type="protein sequence ID" value="KVI01504"/>
        <property type="gene ID" value="Ccrd_020230"/>
    </dbReference>
    <dbReference type="OMA" id="RLIWGGF"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="36366" checksum="EAE7603EACD2A3A9" modified="2016-04-13" version="1">MSLGVAEDDSGTEIHLPADIDWEMLDKSKFFFLGAALFSGVSGMLYPTVVLKTRQQVLVKDTPCFKMAVSILRHDGFRGFYRGFGTSLMGTIPARALYMGALEITKSNVGCATLKMGFSEAKAAAIANAAAGVTAAMAAQMVWTPIDVVSQRLMVQGGNGAKTTVSGAFKYTGGIDAFRKIIHTDGVRGLYRGFGISILTYAPSNAVWWASYSMAHRAIWNGIGCRLKKEGNGGGGGGGVGFTPDSKAVVAVQATSAAVASGVSALVTMPLDTIKTRLQVLDGEGCNGIGATVRKLMKEGGVSACYRGLGPRWVSMAMSATTMITTYEFLKKLSTKNQDSCGGSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3J8</accession>
    <name>A0A103Y3J8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002674">
        <property type="protein sequence ID" value="KVI01879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3J8"/>
    <dbReference type="STRING" id="59895.A0A103Y3J8"/>
    <dbReference type="Gramene" id="KVI01879">
        <property type="protein sequence ID" value="KVI01879"/>
        <property type="gene ID" value="Ccrd_019840"/>
    </dbReference>
    <dbReference type="OMA" id="RPACQVF"/>
    <dbReference type="OrthoDB" id="745247at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045488">
        <property type="term" value="P:pectin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044689">
        <property type="entry name" value="CGR2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208:SF5">
        <property type="entry name" value="OS01G0144000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28952" checksum="F43B68A1773DCFE5" modified="2016-04-13" version="1">MSRRPASLSRRLGDGAGIPFMGSLNPKSRPSPFLSIGLVLVGAFLIIGYVYSGSGGSNADKVALSRLEAGVSCSSEIYQALPYLKKAYRDSMHKVLHVGPDSCAVVSKLLKEEDTEAWGLEPYDLDDSDANCKSLVRKGIVRVADIKFPLPYRSKSFSLVIVSDALDYLSPRYLNKTLPEFSRVSADGFVILSGYPGQRRVKVAEMSKFGRPAKLRSSSWWIRFFVQTKLEENEAATKKFELAAAKKAYQSSCQIFHLKSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5L7</accession>
    <name>A0A103Y5L7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002609">
        <property type="protein sequence ID" value="KVI02963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5L7"/>
    <dbReference type="Gramene" id="KVI02963">
        <property type="protein sequence ID" value="KVI02963"/>
        <property type="gene ID" value="Ccrd_018745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="79" mass="8873" checksum="6B2C3FD242131C49" modified="2016-04-13" version="1">MAGKTTETGVLLENCVGNSDRACGTVGGGGIFVPMLTSDKGCRRRTTYPLERSSTNSSFEESRKIKKRRRRSYKLRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5M4</accession>
    <name>A0A103Y5M4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002611">
        <property type="protein sequence ID" value="KVI02934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y5M4"/>
    <dbReference type="Gramene" id="KVI02934">
        <property type="protein sequence ID" value="KVI02934"/>
        <property type="gene ID" value="Ccrd_018773"/>
    </dbReference>
    <dbReference type="OMA" id="TMTVPCV"/>
    <dbReference type="OrthoDB" id="162989at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47512:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47512">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="38103" checksum="C0EA6263C482F2C7" modified="2016-04-13" version="1">METPSSSSRRITRSQALAMAANDIIPITSRKNEESEKGVLKSRQKTNGGKQEERDRSALIDITNDSPIVGLAIGNLKTPSSTFCKTRMIIQNSQSKQATTPGSGEALLRGQVKXLLQKVEEEAVISKISFEPXISIRSQKDSVNSPMYLLAPTPANTPQVSEDMNNCSESLGVSPVSESYNFSQMLDQEEENGETETTSLITRLLFADSTEKFEENEDDDGSLWSVQVNASTSDEHENDQEFREGYEDDQDFEENYEDDQELVENYQDDERFGENYEEGVDELCEGLSKICVNGGAKFTPRHKRFVYDSDGELEAEEESVESSSPSCFKGLPTPKGTHLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6W8</accession>
    <name>A0A103Y6W8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002336">
        <property type="protein sequence ID" value="KVI03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6W8"/>
    <dbReference type="STRING" id="59895.A0A103Y6W8"/>
    <dbReference type="Gramene" id="KVI03635">
        <property type="protein sequence ID" value="KVI03635"/>
        <property type="gene ID" value="Ccrd_018064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="21766" checksum="10DF57C262FEF616" modified="2016-04-13" version="1">MASRVDHEYDYLFKIVLIGDSGVGKTNILSRFTRNEFCLESKSTIGVEFATRTLEERYRAITSAYYRGAVGALLVYDITKRPTFDNLQRWLRELREHADSNIVLMMAGNKSDLNHLRAVSEQDGQSLAEKEGLSFLETSALESYNIEESFKSVLTDIYRIVSKKALAAEEGSMGAPGKGTTIDVGGETGNTKRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y751</accession>
    <name>A0A103Y751_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002332">
        <property type="protein sequence ID" value="KVI03754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y751"/>
    <dbReference type="STRING" id="59895.A0A103Y751"/>
    <dbReference type="Gramene" id="KVI03754">
        <property type="protein sequence ID" value="KVI03754"/>
        <property type="gene ID" value="Ccrd_017930"/>
    </dbReference>
    <dbReference type="OMA" id="KASETWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Helix-turn-helix" evidence="2">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="39039" checksum="8C3C6760119A7D1D" modified="2016-04-13" version="1" fragment="single">YLVETVKDTYRTVSVSQEGAKFLRSCRPDHQPPLLLPITCESDGNEDKKSTVSDNIASSGHNGMSQPTLKSFVVNQMQHLVTRYGDHLLQSIQQLSKQLDLSLDGAAAVEASQANNNCKAYTITKQPKDLPPAKYGAWKISAPIKVNTVLGYVLDAAREGCVVDWTRLFNEIGLTQEIAANIQAAILKVGSKDKLKPIKEELPEEVDYTHIKAWLTMQDLGMSTEVIPSSNQHSKQHSNGTEESERAAVAYLSEEERNRTERPVPEKTEASLFGDSPRKRQKVEVSEQGAGSSLEITEASLLDWIQNFENGVTLSDILKHFNGSTEATAIDLLSCIESEFLIFKKNNLYKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7P4</accession>
    <name>A0A103Y7P4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF632 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002314">
        <property type="protein sequence ID" value="KVI04034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7P4"/>
    <dbReference type="STRING" id="59895.A0A103Y7P4"/>
    <dbReference type="Gramene" id="KVI04034">
        <property type="protein sequence ID" value="KVI04034"/>
        <property type="gene ID" value="Ccrd_017662"/>
    </dbReference>
    <dbReference type="OMA" id="PIEYEVH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF41">
        <property type="entry name" value="RNA POLYMERASE SUBUNIT BETA, PUTATIVE (DUF630 AND DUF632)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="433"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="92321" checksum="2817B32A03296450" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7Z0</accession>
    <name>A0A103Y7Z0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002299">
        <property type="protein sequence ID" value="KVI04196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7Z0"/>
    <dbReference type="STRING" id="59895.A0A103Y7Z0"/>
    <dbReference type="Gramene" id="KVI04196">
        <property type="protein sequence ID" value="KVI04196"/>
        <property type="gene ID" value="Ccrd_017496"/>
    </dbReference>
    <dbReference type="OMA" id="CGTRRMD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI04196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20634" checksum="F2DD04C0A3809B27" modified="2016-04-13" version="1">MAEGEETQTEVVQSGLPAGRVKRIMKLDKEINKINSEALFVISSATELFVKFLAEKSSEVAIEKKRKTIKLEHLRIAVKRHQPTADFLLDSLPMPPPAQIPTKTDRSRRSSDNDSVPAGTRRIDSFFQKDFMIEKRITEKCNLGSFMGSKLTDSSSALPLRSHITNKRNSLNFGGQAYCSFDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8C3</accession>
    <name>A0A103Y8C3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_017313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002191">
        <property type="protein sequence ID" value="KVI04377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8C3"/>
    <dbReference type="STRING" id="59895.A0A103Y8C3"/>
    <dbReference type="Gramene" id="KVI04377">
        <property type="protein sequence ID" value="KVI04377"/>
        <property type="gene ID" value="Ccrd_017313"/>
    </dbReference>
    <dbReference type="OMA" id="DRTIAME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF176">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="262" mass="29468" checksum="214F1ACAD8C0F02C" modified="2016-04-13" version="1">MIDDRTIAMEAGETSHDDLLGILLQSNYDEIQKTGNERFGMSIDDIIEECKLFYFAGHETVANLLVWTMVLLSRYPQWQELARDEVFEVFGNDNPDLDRLSRLKTVRSYLLILCAVNMILLEVLRLYPGVSALYRMCTKQNKVAGINLPEGTLVIMPILALHHDQETWGDDATEFNPQRFSNGVAKATSGGQVSYFPFGGGPRICIGQNFAMLEAKIAIVMILQRFSFVLSPAYAHAPQSIITLQPQFGAHLILRKVKDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8K4</accession>
    <name>A0A103Y8K4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_017177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002021">
        <property type="protein sequence ID" value="KVI04506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8K4"/>
    <dbReference type="STRING" id="59895.A0A103Y8K4"/>
    <dbReference type="Gramene" id="KVI04506">
        <property type="protein sequence ID" value="KVI04506"/>
        <property type="gene ID" value="Ccrd_017177"/>
    </dbReference>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF20">
        <property type="entry name" value="K(+) EFFLUX ANTIPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="10">
        <location>
            <begin position="202"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="595" mass="65167" checksum="52683D7962ECC9B1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8P7</accession>
    <name>A0A103Y8P7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001986">
        <property type="protein sequence ID" value="KVI04569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8P7"/>
    <dbReference type="STRING" id="59895.A0A103Y8P7"/>
    <dbReference type="Gramene" id="KVI04569">
        <property type="protein sequence ID" value="KVI04569"/>
        <property type="gene ID" value="Ccrd_017113"/>
    </dbReference>
    <dbReference type="OMA" id="YIWHTED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF74">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4 HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="452" mass="52368" checksum="A8912D8982554C13" modified="2016-04-13" version="1" fragment="single">IFKHPLPDVQRGQYSHANSNQCFELEPYRRHKLCLPYLDLKHGQHLMAEQSHSTDRQQRLTRKKRKLTIETEPLTLTPNHTHTCRRKKKSDRGNSDGVADNRKWVFSPRDCSKYKDKFVFVSYNILGVENASNHKDLYLNVLPQFMKWEYRRREVDRFDDLKRILQKDGFRGVYQARSGEARDGCAIFWKDALFSLLHKDNIEFKRFGLRDNIAQFCVLKMTAYQKHIDDPENLKVQPSRSILVGNIHVLFNPSRGDVKLGQVRLFLAKAHRLSQKWGNIPAILGGDLNSMPQSAMYQFIVSSELNIQHHERKRISGQICPLDHPRLPSQSNYSSRPLLHRWSKEELRLATGTEESVYLRHNLKLNSAYHGVPASRLTRDSHGEPLATSFHSRFMGTVDYIWHTKELVPVKVLETLPIEILKKTKGLPSKIWGSDHLALVCELAFADESCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9K4</accession>
    <name>A0A103Y9K4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Intracellular vesicle trafficking and protein transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001891">
        <property type="protein sequence ID" value="KVI05039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9K4"/>
    <dbReference type="STRING" id="59895.A0A103Y9K4"/>
    <dbReference type="Gramene" id="KVI05039">
        <property type="protein sequence ID" value="KVI05039"/>
        <property type="gene ID" value="Ccrd_016633"/>
    </dbReference>
    <dbReference type="OMA" id="HECIKIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000456">
        <property type="entry name" value="Ras-related protein RABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI05039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24286" checksum="A3EEA540E6C6F155" modified="2016-04-13" version="1" fragment="single">MGSSSSPSATPYLNGDIKGGGRRSQISPTSYDYSFKILVIGDSGVGKSSLLLSFVSNCQNPSQDISPTIGVDFKMKMLTIDGKRLKLTIWDTAGQERFGTLTSSYYRGAHGIMLVYDVTRRETFTNLSEVWAREVELYSTHPDCVKILVGNKVDRDVERAVTVEEGMALAKKHDCLFYECSARTRANVQQCFKDLTVKILDKPGLLEQGSVVVKRQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA87</accession>
    <name>A0A103YA87_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Hemerythrin/HHE cation-binding motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_016295</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Probable E3 ubiquitin-protein ligase that may regulate the response to iron deficiency and thus contributes to iron homeostasis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Binds zinc and iron ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001873">
        <property type="protein sequence ID" value="KVI05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA87"/>
    <dbReference type="STRING" id="59895.A0A103YA87"/>
    <dbReference type="Gramene" id="KVI05382">
        <property type="protein sequence ID" value="KVI05382"/>
        <property type="gene ID" value="Ccrd_016295"/>
    </dbReference>
    <dbReference type="OMA" id="EWWEGSP"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098711">
        <property type="term" value="P:iron ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034756">
        <property type="term" value="P:regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.520:FF:000009">
        <property type="entry name" value="Zinc finger protein BRUTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000208">
        <property type="entry name" value="Zinc finger protein-related isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="19">
        <location>
            <begin position="991"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="20">
        <location>
            <begin position="1063"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1127"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1243" mass="140276" checksum="BDD9AAFC0A4A754C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDW3</accession>
    <name>A0A103YDW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDW3"/>
    <dbReference type="STRING" id="59895.A0A103YDW3"/>
    <dbReference type="Gramene" id="KVI07294">
        <property type="protein sequence ID" value="KVI07294"/>
        <property type="gene ID" value="Ccrd_014268"/>
    </dbReference>
    <dbReference type="OMA" id="ERPCETT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052796">
        <property type="entry name" value="Nod_factor_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32175">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32175:SF0">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="339" mass="39122" checksum="DBE821C37130020C" modified="2016-04-13" version="1">MADDLCFFIKDMLIIRAPVKNYLVLRICLVAFVMVCGVFMCSIGLKQISNFTKAGYIDTKMVARPCEMPNIEKWERSYVHFPKPATFNRAECACNPVRYFVISSTQRSGSGWFETLLNSHTNVSSNGEIFSVKPRRSNMSTIVDTLDKIYDLDWLTSASKNECTAAVGLKWMLNQGFLQNHEAITEYFKTKGVSVIFLFRRNLLRRRISILANAYDQSAKPLNGKHKSHAKILASYRPSINTTLLIPELKQADNMVKQALDYFNSTRHIILYYEDIIKNRSVLNDVQDFLRIPRMKLKSRQVKIHKGPLHEQVENWSDIQKVLNGTPYESFLHEDYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFN7</accession>
    <name>A0A103YFN7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001160">
        <property type="protein sequence ID" value="KVI08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFN7"/>
    <dbReference type="STRING" id="59895.A0A103YFN7"/>
    <dbReference type="Gramene" id="KVI08246">
        <property type="protein sequence ID" value="KVI08246"/>
        <property type="gene ID" value="Ccrd_013385"/>
    </dbReference>
    <dbReference type="OMA" id="LIRPMRQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47603">
        <property type="entry name" value="PPR CONTAINING-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47603:SF1">
        <property type="entry name" value="PPR CONTAINING-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32028" checksum="AE25F96E266F9EA8" modified="2016-04-13" version="1">MLRSNAIAGLIRPMRQLGIFRVPISNCSQLTVIQDHIPTPVDENYLQDHFNIGKDAEGIGKLQKTYNVSKKDKISVLVRSLLDLEDSKEAVYGALDAWVVGEREFPIGRLKTALIALEKMQEWHKVVQVIKWMLSKGQGVTVGTYGQLIRALDMDLRVEEANKLWAKKLGRDVQSVPWKVCDIMISVYYRNEMWEELVKLFKGLEAHGRKPPDQSIVKKVAESYEKLGLVEEKERFVEKYKSSFTKTRGKYGRKASKESSTIEDNPSRNQQSISIDFNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH29</accession>
    <name>A0A103YH29_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gibberellin regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001077">
        <property type="protein sequence ID" value="KVI08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH29"/>
    <dbReference type="STRING" id="59895.A0A103YH29"/>
    <dbReference type="Gramene" id="KVI08948">
        <property type="protein sequence ID" value="KVI08948"/>
        <property type="gene ID" value="Ccrd_012668"/>
    </dbReference>
    <dbReference type="OMA" id="VNECPCY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF103">
        <property type="entry name" value="GIBBERELLIN REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119710" evidence="2">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="10464" checksum="D6E03D0CA1A4C824" modified="2016-04-13" version="1">MKTLFPFAFLLIAALLLISSGAATSPAPSPAPSQSAGTFGCDNKCANRCANAGYKERCLKYCGICCGKCKGCVPSTPYAPKSQCPCYQKLKNSKGTDKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIN4</accession>
    <name>A0A103YIN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Optic atrophy 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001040">
        <property type="protein sequence ID" value="KVI09836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIN4"/>
    <dbReference type="STRING" id="59895.A0A103YIN4"/>
    <dbReference type="Gramene" id="KVI09836">
        <property type="protein sequence ID" value="KVI09836"/>
        <property type="gene ID" value="Ccrd_011777"/>
    </dbReference>
    <dbReference type="OMA" id="KMYVMNL"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF22">
        <property type="entry name" value="OS02G0312500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="19237" checksum="4C1674500ADDC5E4" modified="2016-04-13" version="1">MILPFAKLGTLALKTFCKPIAKRIKKEAGRHPKFRHSIINIAQVNHRFTTKLQRRIYGHAMDVAIRPLNEDKAVQAAADLLGELFVFTVAGTAVIFEVQRSSKSEARKEALRKQELEALRQRDEDLAREIEMLKYKIKEMERVAKGQGLGTLFNFRKPHAIEDGQSKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIV3</accession>
    <name>A0A103YIV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIV3"/>
    <dbReference type="STRING" id="59895.A0A103YIV3"/>
    <dbReference type="Gramene" id="KVI09914">
        <property type="protein sequence ID" value="KVI09914"/>
        <property type="gene ID" value="Ccrd_011701"/>
    </dbReference>
    <dbReference type="OMA" id="FFAFDRK"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="488" mass="53895" checksum="8A223386C94D708B" modified="2016-04-13" version="1">MPCESVMEFSATQIISKSTVFPATKSTLSDLKLSASDLPMLSCHYIQKGNLFPRPSIAITDLLLLLQQGLSRALAHFPPLAGRLITDANGYVYITCNDAGAQFVHASATHLTVNDVISPTHVPDSVKGFFSFDRMVSYDGHFNPILAVQVTELDDGVFIGFSVNHAVVDGTSLWNFINTFAEVCRGANLISKQPFFTRESVLISPAVLRVPADGLKVTFDEYAPLSERVFSFSRESILKLKDRTNNRKKFSCYGNGEINAAEVMGKQSNDPIKLSDEKVTTLIGNWIRNAVVTKTEPAREISSFQSLCALLWRGVTRARKFPNSKTTTFRMAVNCRHRLEPKLETLYFGNAIQSIPTYATAGDVLSHDLKWCAEQLNKNVLSHDDTMVRRAVHSWEQDPRCFPLGNFDGAMLTMGSSPRFPMFDNDFGWGKPVAVRSGRANKFDGKISAFPGKEGGGSVDLEVVLSPETMAALELDPEFMQYVSGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ05</accession>
    <name>A0A103YJ05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ05"/>
    <dbReference type="STRING" id="59895.A0A103YJ05"/>
    <dbReference type="Gramene" id="KVI09907">
        <property type="protein sequence ID" value="KVI09907"/>
        <property type="gene ID" value="Ccrd_011690"/>
    </dbReference>
    <dbReference type="OMA" id="MEWVERY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051564">
        <property type="entry name" value="LRR_receptor-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055:SF55">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14021" checksum="1480F81A94D203F4" modified="2016-04-13" version="1">MTKEGDIYSFGILLLETITGKRPTDLVFVEGLNLYGYVMMALPDQVMEIVEPTLLHDLEDEMEAANVNHRSGEDEARRWKRSEEGMISLARIGLACSMESPKQRTDASKIVHELHHINGIHTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ63</accession>
    <name>A0A103YJ63_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ63"/>
    <dbReference type="STRING" id="59895.A0A103YJ63"/>
    <dbReference type="Gramene" id="KVI10121">
        <property type="protein sequence ID" value="KVI10121"/>
        <property type="gene ID" value="Ccrd_011480"/>
    </dbReference>
    <dbReference type="OMA" id="NDPDKAW"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000123">
        <property type="entry name" value="Putative methyltransferase PMT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1049">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="640" mass="72547" checksum="9D99AF24C5977BBD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJH7</accession>
    <name>A0A103YJH7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_011415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJH7"/>
    <dbReference type="Gramene" id="KVI10195">
        <property type="protein sequence ID" value="KVI10195"/>
        <property type="gene ID" value="Ccrd_011415"/>
    </dbReference>
    <dbReference type="OMA" id="DMGSSAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000234">
        <property type="entry name" value="Probable inactive receptor kinase RLK902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF74">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="298"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="606" mass="66381" checksum="6728A3EC95F6456C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJJ3</accession>
    <name>A0A103YJJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001023">
        <property type="protein sequence ID" value="KVI10316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJJ3"/>
    <dbReference type="Gramene" id="KVI10316">
        <property type="protein sequence ID" value="KVI10316"/>
        <property type="gene ID" value="Ccrd_011282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="9900" checksum="7E26C94CB96ED42F" modified="2016-04-13" version="1">MESEYGMYRKGSSGWSSMVGSEEFQETDIWSVLSERKGFDSKFKGSSSSFTSKSISFPSAALMIPRSNNPEVPQQQSAPVQEEHLKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKU5</accession>
    <name>A0A103YKU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exon junction complex, Pym</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000968">
        <property type="protein sequence ID" value="KVI10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKU5"/>
    <dbReference type="STRING" id="59895.A0A103YKU5"/>
    <dbReference type="Gramene" id="KVI10986">
        <property type="protein sequence ID" value="KVI10986"/>
        <property type="gene ID" value="Ccrd_010609"/>
    </dbReference>
    <dbReference type="OMA" id="NDRSCCF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="208" mass="23091" checksum="C695FDC3BDB10DEE" modified="2016-04-13" version="1" fragment="single">MATNAAVHRRGGEEQVKVQAAEISKTLKEGERILAPTRRPDGTLRKPIRIRAGYVPQDEVAVYKSKGSQLKKEIESLEILPPGYDPQEDVVNKSKTKSAKRNERKKEKRLQAAFDNGINEVSSTGDVEEAALGPVESIVSQIDEITISGNRSVVAPPSNSTECSPDIDKRIRALKKKIRLTEALQQKTGQDLNPEQLEKVAKLEDWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLJ8</accession>
    <name>A0A103YLJ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maturase MatK, N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_010350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intron maturase 2 family. MatK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000658">
        <property type="protein sequence ID" value="KVI11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLJ8"/>
    <dbReference type="Gramene" id="KVI11242">
        <property type="protein sequence ID" value="KVI11242"/>
        <property type="gene ID" value="Ccrd_010350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002866">
        <property type="entry name" value="Maturase_MatK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024942">
        <property type="entry name" value="Maturase_MatK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34811">
        <property type="entry name" value="MATURASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34811:SF1">
        <property type="entry name" value="MATURASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01824">
        <property type="entry name" value="MatK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maturase MatK N-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="475" mass="53348" checksum="D665A9999D1931A9" modified="2016-04-13" version="1" fragment="single">IQFARVCYGEVDAEKDKCIIDVYSKVDDIISIARNEKSILARLGRNLDKFMVNIEKEVPYEDPSQHKLDAIRDHPGVSIPDEVDILPPSGIRNKGCGTGKRLAADTPVLLLPLNYPQQQRLVYPMDLTPNQRMVARCLQTKQLAAHYFLARVKKSKLQIPTRLHSASLLITITRKLNLNMAPASANLCTTFITSLGLIRSLLNCFRHAVVMSSSHEDCSTEFKSIPPIGSPSTSCMDSTVIGIAPSFILMFIAATFNISTTVVLTASDSVPFTHSRLSLSFTKQPWLCAISRSVSSITQQLQVCPSHSSIFTQQPRLCAVSWLGSLFAQQARLDNVCGLASPSHSSHGLVMVCGLASPSHTQPWPWVDLRYSLKRSGDSRLQRLPQASITVLIMTFLLMNKWKYYFVNFWKSYFYLWSEPGRIYINQLSNHSLDFLGSYSSLLTFPKVSSISQRLSRRRIWYLDIICINDLANHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLZ6</accession>
    <name>A0A103YLZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000085">
        <property type="protein sequence ID" value="KVI11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLZ6"/>
    <dbReference type="STRING" id="59895.A0A103YLZ6"/>
    <dbReference type="Gramene" id="KVI11547">
        <property type="protein sequence ID" value="KVI11547"/>
        <property type="gene ID" value="Ccrd_010040"/>
    </dbReference>
    <dbReference type="OMA" id="SWRCAWY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF8">
        <property type="entry name" value="DUF707 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="45462" checksum="0D30BC7711499C24" modified="2016-04-13" version="1">MKNTSVDLPIKRHKSLLCSRLFGAILVSAAFFISSAIIVVDHKKRFPELQNSDAMQADPTNICENQCSLDGSEALPKGIVVKTSDLEMRPLWGPRKKRKNPKSPMSLLAMAVGKKQKANVNEMIKKFPSDDFVIMLFHYDGNVDEWKDLEWSSRAIHLSAISQTKWWFAKRFLHPDVVSEYAYIFLWDEDLGVQNFDARRYVSIIRNEGLHISQPALDPDKSEVHHEMTTREKGSTLHRRIERMSRSKKKCYRNSTDPPCTGWVEMMAPVFSKEAWRCVWYMIQNDLIHAWGLDMQLGYCAQGNRTQYIGIVDSEYVVHYGLPTLGGSPQNKTNTESSIEESSSLQDKVSLESNHTDIRAEVRKQSLNELEQFKRRWRKAVQEDGCWVDPYKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118H0W1</accession>
    <name>A0A118H0W1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008407">
        <property type="protein sequence ID" value="KVG23795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118H0W1"/>
    <dbReference type="STRING" id="59895.A0A118H0W1"/>
    <dbReference type="Gramene" id="KVG23795">
        <property type="protein sequence ID" value="KVG23795"/>
        <property type="gene ID" value="Ccrd_026510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057075">
        <property type="entry name" value="bHLH_IRO3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47075">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47075:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH47-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23177">
        <property type="entry name" value="bHLH_IRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG23795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="245" mass="27222" checksum="2F157BE7F8B00EA6" modified="2016-04-13" version="1">MESSKKGTCRPHSSSPLRNHSFLPPHAAPSPFLRWCVTASLSQVHKVGMGAKNSPTSLLPSKKNLGKVPKRIHKAEREKMKREHLNELFLKLAEALEVGEQNSGKASILGETTRFIKVMLDQIKSLKKENAALLSESQYVKLEKNEIEDETCGLQIQIGELKRRLTVKEEKKLDLNAPPIESQEQQCLMEDSPIVNPVFVFPACLNFQGGGGDGDGGVVKAASNVRKPHPRYPTSLDSWHFQLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I5B6</accession>
    <name>A0A118I5B6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007516">
        <property type="protein sequence ID" value="KVG85968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I5B6"/>
    <dbReference type="STRING" id="59895.A0A118I5B6"/>
    <dbReference type="Gramene" id="KVG85968">
        <property type="protein sequence ID" value="KVG85968"/>
        <property type="gene ID" value="Ccrd_026144"/>
    </dbReference>
    <dbReference type="OMA" id="QVNCDIS"/>
    <dbReference type="OrthoDB" id="1932220at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF110">
        <property type="entry name" value="VINORINE SYNTHASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG85968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="446" mass="48962" checksum="41AEECB375DD92D8" modified="2016-04-13" version="1">MEIEIISKESIKPSSPTPHHLKTFELSLLDQLVVDPYVPIVLYYPNHNGSNVLQALERSLALKKSLSKTLTQFYPLAGTIKNGLSIDCNDVGACYAIALVRCGLNELLSHPDHQLLNGLLPFQPSFEGSSVGARVTNVQVNIFECGGIAIGLCISHRIVDGAALRTFLEGWTNMACGAKEVVYPNLAAPSLFPAKDSWLRDSSMAMCGSWLKEGKCVTKRFVFDSDSIARLKAEATKNGVKNPTRVEVVSALIWKSAMAASKQITGFQKPSRLTHLVNLRRKLSATLSKDSIGNVIWPATAKFQANYETTLHGLVNKVRESISKIDIEFVNKAQGEKGCVAMQESIKEMGEISSKGTMDNYTFTSWCKMGFYQMDFGWGVPSWVSGIIGHGSPVFINQVTLMDTVFGEGIEAWVNLDEEEMEILQGNSELQAYASMDPSPLPKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT92</accession>
    <name>A0A118JT92_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DC-UbP/UBTD2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT92"/>
    <dbReference type="STRING" id="59895.A0A118JT92"/>
    <dbReference type="Gramene" id="KVH89457">
        <property type="protein sequence ID" value="KVH89457"/>
        <property type="gene ID" value="Ccrd_008560"/>
    </dbReference>
    <dbReference type="OMA" id="RISTEIW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="144" mass="16670" checksum="5B02DF43617C2CA9" modified="2016-04-13" version="1">MGCVKSSNVVNDQETACFRVPAHNRPNRLRKPRPWRHNRPITGEQLTNMRNMFWHNAPHFGGRQEIWSALRAAAESDLPYAQAIIDNNGIRVENPYMTVCYDEGGARYELPLYVLAEPTNLEGSVRRPFVVNRPNIIEETLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUG5</accession>
    <name>A0A118JUG5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-binding EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004960">
        <property type="protein sequence ID" value="KVH91464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUG5"/>
    <dbReference type="STRING" id="59895.A0A118JUG5"/>
    <dbReference type="Gramene" id="KVH91464">
        <property type="protein sequence ID" value="KVH91464"/>
        <property type="gene ID" value="Ccrd_006509"/>
    </dbReference>
    <dbReference type="OMA" id="IVGSPWY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001423">
        <property type="entry name" value="Calcium-dependent protein kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31312" checksum="B8D18B7A83806658" modified="2016-04-13" version="1">MKHLPKHLNLVALRDAYEDKNAVHIVMELCEGGEVFKEIVGSPWYMAPEVLKRNYGPEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPKVSENAKDLVKKMLNPDPKRRLTAQQVLEHPWLLDAKAAPNVSLGEVDLDGDGTINYGEFVAVNVHLKRMANDEHLHKAFAFFDQNQNGFIEFEDLRHALSDEANAEGIEGVINTIMLDVDTDKDGRISYEEFAAMMKAGTDWRKASRQYSRERFNSLSSKLMKDGSLQLPANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUJ3</accession>
    <name>A0A118JUJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004841">
        <property type="protein sequence ID" value="KVH92156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUJ3"/>
    <dbReference type="STRING" id="59895.A0A118JUJ3"/>
    <dbReference type="Gramene" id="KVH92156">
        <property type="protein sequence ID" value="KVH92156"/>
        <property type="gene ID" value="Ccrd_005811"/>
    </dbReference>
    <dbReference type="OMA" id="EESYGHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47689">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47689:SF2">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="271" mass="30069" checksum="605CC9478EFE407D" modified="2016-04-13" version="1">MGLAWLASRALRSSSSRVLSYRTIFSTPDLCKPVALGARFHFPNSDPKSCSVHIARFYYHDQLSISVNWRKQRSVASSLVALLPALFLGLSLTPVLAEDASTELTETDSSGSDFTGLRKIDDGSGKLEDAERLFVGALQEAKEGFGERDPHVASACNNLAELYRVKKAFDKAEPLYLEAINILEESYGHEDVRVGAALHNLGQFYLLQKKLDAAHACYKIKRQVLGEDHADYAETMYHLGKVLYLQGNVKDAEALITESIQIFEVHSFVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUS4</accession>
    <name>A0A118JUS4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Filament-like plant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004815">
        <property type="protein sequence ID" value="KVH92514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUS4"/>
    <dbReference type="STRING" id="59895.A0A118JUS4"/>
    <dbReference type="Gramene" id="KVH92514">
        <property type="protein sequence ID" value="KVH92514"/>
        <property type="gene ID" value="Ccrd_005454"/>
    </dbReference>
    <dbReference type="OMA" id="CVEKDAI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008587">
        <property type="entry name" value="FPP_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580">
        <property type="entry name" value="FILAMENT-LIKE PLANT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580:SF22">
        <property type="entry name" value="FILAMENT-LIKE PLANT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05911">
        <property type="entry name" value="FPP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="582"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="94275" checksum="DA393B56D565EC97" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXA9</accession>
    <name>A0A118JXA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004258">
        <property type="protein sequence ID" value="KVH96654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXA9"/>
    <dbReference type="Gramene" id="KVH96654">
        <property type="protein sequence ID" value="KVH96654"/>
        <property type="gene ID" value="Ccrd_001256"/>
    </dbReference>
    <dbReference type="OMA" id="PQILWYL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000521">
        <property type="entry name" value="Protein kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF20">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="300" mass="34001" checksum="F40F91D6E6AFD4D3" modified="2016-04-13" version="1">MNDGLMFRIRLLLQSRSVPVIFLRRFSYKDIKRATDSFSRVITTSSHGASYKARFQGGHVAVVKEIHLIGQEDDHIFYREVQLLGRLHHRHVVALNGYSVGQKRFLVFENVENGSLKEHLNDPLRTPLDWRIRLKIAVGVAAALEYLHFFCDPPVYHVSISSNTIMLDENFDAKLSDVGLLGSGSDQVTAWRTSSSNETTGQAYGNIMYQLGLLILELITGQSSEKTGDDLVEWIEESCFPASMDNMIDPDLGNDYDSRELTGLLAVARFCLKSVDKPNSFTPQIYRYLQRKISIRKTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXG4</accession>
    <name>A0A118JXG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_000504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003833">
        <property type="protein sequence ID" value="KVH97402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXG4"/>
    <dbReference type="STRING" id="59895.A0A118JXG4"/>
    <dbReference type="Gramene" id="KVH97402">
        <property type="protein sequence ID" value="KVH97402"/>
        <property type="gene ID" value="Ccrd_000504"/>
    </dbReference>
    <dbReference type="OMA" id="NLVETMM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000229">
        <property type="entry name" value="Homeobox-leucine zipper protein HDG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042160">
        <property type="entry name" value="HD-Zip_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057993">
        <property type="entry name" value="HD-Zip_IV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN MERISTEM L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654:SF94">
        <property type="entry name" value="START DOMAIN, HOMEODOMAIN-LIKE, START-LIKE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25797">
        <property type="entry name" value="PDF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="14">
        <location>
            <begin position="255"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH97402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="686" mass="75576" checksum="5BD5F31B4CDDE1DB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXJ1</accession>
    <name>A0A118JXJ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004306">
        <property type="protein sequence ID" value="KVH96446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXJ1"/>
    <dbReference type="STRING" id="59895.A0A118JXJ1"/>
    <dbReference type="Gramene" id="KVH96446">
        <property type="protein sequence ID" value="KVH96446"/>
        <property type="gene ID" value="Ccrd_001463"/>
    </dbReference>
    <dbReference type="OMA" id="YIHATSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF2">
        <property type="entry name" value="COPPER-TRANSPORTING ATPASE HMA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="P-type ATPase A" evidence="6">
        <location>
            <begin position="61"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="21227" checksum="4BB28F7A187FB502" modified="2016-04-13" version="1">MDLRSKFSFETSTLLISFILLGIYFDSISKGKTSDALANLTDLTPDTACLLTMGDDKNVISETEISTQLIQRNDILRIFPSSKFPVDGIVIDGHGYVNESMITGEAVPVAKNPGDKVIGGTVNDNGCLLIKAIHIGSETAHSQIVQIFEAAQLARAPVQKLADRISRFFVPAVSCLPLHYIHATSHGHKVDFGCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY18</accession>
    <name>A0A118JY18_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY18"/>
    <dbReference type="STRING" id="59895.A0A118JY18"/>
    <dbReference type="Gramene" id="KVH97257">
        <property type="protein sequence ID" value="KVH97257"/>
        <property type="gene ID" value="Ccrd_000630"/>
    </dbReference>
    <dbReference type="OMA" id="TNEYEHN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="104"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="507" mass="56488" checksum="11D23DCA605B6F01" modified="2016-04-13" version="1">MQLTVHLFLRYSLPFLPTSPRKQLLYFHSLRRSISAATATMVANAGNSSLLEHVAGAWYSVPELRLRDHRFTVPLDYSLSESPKISVFAREVVAVGKEDQSLPYLLFLQGGPGFESPRPTEASGWLSKACEEHRVILMDQACSFLTVRGTGLSTPLTTSSMLQTKSAQDLVDYLKYFRADNIVNDAEFIRKHLVSDAGPWKVLGQSFGGFCGVTYLSFAPEGLKEVYLTGGIPPIGDGCTAEAVYKACIGPLVLQNEKYYKRYPQDIEIIRDVVNHLAESEGGGVPLPSGGILTPRGLQLLGLTGLGASTGFERLHYLFERVWDPVIVPGAKKQISYYFLNAFEKWLSFDTNPLYALMHESIYCQGAASRWAANRVRTEHESKLDAVKAAKEGRPVLLTGEMVFPWMFDEIHALRPFKEAANLLAEKKDWPPLYNKTTLNNNKVPVAAAVYYEDMFVNFNLATETAAQIAGIRLWVTNEYMHSGLRDGAGHVLDHLMRLLNGKKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY43</accession>
    <name>A0A118JY43_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004130">
        <property type="protein sequence ID" value="KVH96864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY43"/>
    <dbReference type="Gramene" id="KVH96864">
        <property type="protein sequence ID" value="KVH96864"/>
        <property type="gene ID" value="Ccrd_001043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="54" mass="6302" checksum="99FD320BDCBA5608" modified="2016-04-13" version="1">MVGNFDLGLVDSLHLSCTRRSTNMEDLLKLNRHWVEDLLLLQVLRVLQRTRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY66</accession>
    <name>A0A118JY66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY66"/>
    <dbReference type="Gramene" id="KVH98094">
        <property type="protein sequence ID" value="KVH98094"/>
        <property type="gene ID" value="Ccrd_023699"/>
    </dbReference>
    <dbReference type="OMA" id="WATANDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31150">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31150:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="692"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="752" mass="80864" checksum="D35B83FDC3104A0C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYC7</accession>
    <name>A0A118JYC7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004116">
        <property type="protein sequence ID" value="KVH96895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYC7"/>
    <dbReference type="STRING" id="59895.A0A118JYC7"/>
    <dbReference type="Gramene" id="KVH96895">
        <property type="protein sequence ID" value="KVH96895"/>
        <property type="gene ID" value="Ccrd_001013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="81" mass="9094" checksum="694561D075BD0A5F" modified="2016-04-13" version="1" fragment="single">MITPSLFGFDFLHLCLGFGFDFLLSLSKRTLKLVRKAAEHKCLKRGVKEVVKSIRRGATKRPTCCVLVLTKPTKGELGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ68</accession>
    <name>A0A118JZ68_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine peptidase, asparagine active site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003808">
        <property type="protein sequence ID" value="KVH98155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZ68"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159826" evidence="4">
        <location>
            <begin position="23"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="6">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="131"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="6">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="491"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="715" mass="79540" checksum="4717BE800048100B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K250</accession>
    <name>A0A118K250_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterile alpha motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002329">
        <property type="protein sequence ID" value="KVI03813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K250"/>
    <dbReference type="STRING" id="59895.A0A118K250"/>
    <dbReference type="Gramene" id="KVI03813">
        <property type="protein sequence ID" value="KVI03813"/>
        <property type="gene ID" value="Ccrd_017893"/>
    </dbReference>
    <dbReference type="OMA" id="PQLYNRK"/>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000054">
        <property type="entry name" value="Sterile alpha motif domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF74">
        <property type="entry name" value="OS08G0526500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="207" mass="22910" checksum="7E75D3C717679830" modified="2016-04-13" version="1">MYADRVETAPKSSIKDRLNGGALDNSRSRRQITGKRQRQNDDKWEHDLYEQADPQISNRRVGVLDLRLKLQKKSNQQATQGARGPLSGGVRDLREKLSGITYSLPAVTVQAKPKSVPESSKSTRRSVVAEAPVAETKKVANIASKKKKAETVDTFLQALGLEKYSITFQAEEVDMTALLHMTDEDLKAIGIPMGPRKKILLALESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2B8</accession>
    <name>A0A118K2B8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002306">
        <property type="protein sequence ID" value="KVI04125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2B8"/>
    <dbReference type="STRING" id="59895.A0A118K2B8"/>
    <dbReference type="Gramene" id="KVI04125">
        <property type="protein sequence ID" value="KVI04125"/>
        <property type="gene ID" value="Ccrd_017567"/>
    </dbReference>
    <dbReference type="OMA" id="FGRMETR"/>
    <dbReference type="OrthoDB" id="1249301at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10930" checksum="6382E8FBD5F29169" modified="2016-04-13" version="1">MAILMPRIIQANQILRRSLSNGSSNTYMAIPKGHFVVYVGEQEKKRFVVPVSLLSQPAFQELLYLAEEEFGYNHPMGGLTIPCSEDIFTDLASRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2F9</accession>
    <name>A0A118K2F9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ-containing protein, X-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002238">
        <property type="protein sequence ID" value="KVI04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2F9"/>
    <dbReference type="Gramene" id="KVI04305">
        <property type="protein sequence ID" value="KVI04305"/>
        <property type="gene ID" value="Ccrd_017389"/>
    </dbReference>
    <dbReference type="OMA" id="EVFGAMF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF14">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159896" evidence="2">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="387" mass="43990" checksum="E58797D24DD171FD" modified="2016-04-13" version="1">MQLFSLFQLSLLIVHNWKGYSISLFRHSHHSSSSSSLELGVDQKQLIVMVKETEYYDVLGVTPLVSEDHIRKAYYLKVHDKFIPIKIQTILKLQRDFRRVLGEAYQVLSDPVKRDAYDRNGKCSISKDAMLDSTAVFAVLFGSELFEDYVGHLAVATMASAELALENDIPEILHDKLKATFGANMLHTIGYIYERQGALELGKKVIYLGVPFMAEWVRNKGHFWKSQITAAKGAFQLLQLQEDARRQFKMDGTNDAESHLRSSKDTLMNSLWKLNVVDIEVTLLHVCQMVLHENNVRKEELKARAVALKLLGKIFQREKNSQSGTSKKKIASDDTSSSSDSSDDEDSPRTLNYRAPFITQGIGRLFRCLCNPAYDVDDDEIVYKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3H5</accession>
    <name>A0A118K3H5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine-containing phosphotransfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3H5"/>
    <dbReference type="STRING" id="59895.A0A118K3H5"/>
    <dbReference type="Gramene" id="KVI05928">
        <property type="protein sequence ID" value="KVI05928"/>
        <property type="gene ID" value="Ccrd_015732"/>
    </dbReference>
    <dbReference type="OMA" id="REYCRDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000001">
        <property type="entry name" value="Histidine-containing phosphotransfer protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF43">
        <property type="entry name" value="HISTIDINE-CONTAINING PHOSPHOTRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="15544" checksum="412653AB51A96D64" modified="2016-04-13" version="1">MERNQMQMHRQIATIRKSLFDQGYLDEQFVQLEELQDNSNPNFVEEVVTLFYRDSARFLYNLDQALEKRPLDFSRLDSLMHQFKGSSSSIGAKKVKIECTHFRDYCNARNTEGCQDKLGPSRRHAGPDKSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K593</accession>
    <name>A0A118K593_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock chaperonin-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001092">
        <property type="protein sequence ID" value="KVI08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K593"/>
    <dbReference type="STRING" id="59895.A0A118K593"/>
    <dbReference type="Gramene" id="KVI08733">
        <property type="protein sequence ID" value="KVI08733"/>
        <property type="gene ID" value="Ccrd_012893"/>
    </dbReference>
    <dbReference type="OMA" id="YWTDSLA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000005">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000042">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF55">
        <property type="entry name" value="UBIQUILIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
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            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
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            <end position="566"/>
        </location>
    </feature>
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            <end position="25"/>
        </location>
    </feature>
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            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="569" mass="60466" checksum="30663705BA3D7509" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5F5</accession>
    <name>A0A118K5F5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001077">
        <property type="protein sequence ID" value="KVI08968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5F5"/>
    <dbReference type="STRING" id="59895.A0A118K5F5"/>
    <dbReference type="Gramene" id="KVI08968">
        <property type="protein sequence ID" value="KVI08968"/>
        <property type="gene ID" value="Ccrd_012653"/>
    </dbReference>
    <dbReference type="OMA" id="YSNHRHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="18831" checksum="5226B8CF65992D95" modified="2016-04-13" version="1">MERREACKGGKDVSKKSAPTQSASGNTTAPEAHLSRRGHAPSAQPTGPPVKTAKSSSATNVSAYDQQQITELKLTMDSLEKERDFYSNHRHAEEDASIVEEAQAMLLNQEKQGVSLNPVSEDVEENKAKSDTQTRKSIVNLEVDVAANTTLSPRQRISDAYDVHCSGSPLMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K688</accession>
    <name>A0A118K688_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hapless 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001024">
        <property type="protein sequence ID" value="KVI10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K688"/>
    <dbReference type="STRING" id="59895.A0A118K688"/>
    <dbReference type="Gramene" id="KVI10273">
        <property type="protein sequence ID" value="KVI10273"/>
        <property type="gene ID" value="Ccrd_011317"/>
    </dbReference>
    <dbReference type="OMA" id="RMQNGAN"/>
    <dbReference type="OrthoDB" id="1929441at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767:SF1">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="807"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130471" checksum="24521A7B1C509BDC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6F7</accession>
    <name>A0A118K6F7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP-glucose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">ADP-glucose synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-D-glucose-1-phosphate adenyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_011014</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01001011">
        <property type="protein sequence ID" value="KVI10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6F7"/>
    <dbReference type="STRING" id="59895.A0A118K6F7"/>
    <dbReference type="Gramene" id="KVI10577">
        <property type="protein sequence ID" value="KVI10577"/>
        <property type="gene ID" value="Ccrd_011014"/>
    </dbReference>
    <dbReference type="OMA" id="YPLTKMR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030931">
        <property type="term" value="C:heterotetrameric ADPG pyrophosphorylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02508">
        <property type="entry name" value="ADP_Glucose_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04651">
        <property type="entry name" value="LbH_G1P_AT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000030">
        <property type="entry name" value="Glucose-1-phosphate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF12">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE LARGE SUBUNIT 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25247">
        <property type="entry name" value="LbH_GLGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="18">
        <location>
            <begin position="90"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="51101" checksum="13AD6C425788EF77" modified="2016-04-13" version="1">MATVGAFNPPHFFSSSSSGAAIVADRRYLHAPSLSFSSSHLSGDKIFSASSVRRRCSRGRASVIVSPKAVSDSKNSQTCLDPDASQSVLGIILGGGAGTRLYPLTKKRAKPAVPLGANYRLIDIPVSNCLNSNVSKIYVLTQFNSASLNRHLSRAYASNMGGYKNEGFVEGTADAVRQYLWLFEEHNVLEFLILAGDHLYRMDYERFIQAHRETDADITVAALPMDEKRATAFGLMKIDEEGRIIEFAEKPKGEQLKAMKVDTTILGLDEERAKEMPYIASMGIYVISKDVMLNLLRDKFPAANDFGSEVQAYLYDGYWEDIGTIEAFYNANLGITKKPVPDFSFYDRSSPIYTQPRYLPPSKMLDADVTDSVIGEGCMIKNCKIHHSVVGLRSCIAEGSVPIGIGKNTHIKRAIIDKNARIGNDVKIINSDNVQEAARETDGYFIKSGIVTVIKDVLIPSGTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L1</accession>
    <name>A0A118K6L1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_010739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000988">
        <property type="protein sequence ID" value="KVI10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L1"/>
    <dbReference type="STRING" id="59895.A0A118K6L1"/>
    <dbReference type="Gramene" id="KVI10848">
        <property type="protein sequence ID" value="KVI10848"/>
        <property type="gene ID" value="Ccrd_010739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="462"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="580"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="697"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="823" mass="90513" checksum="F2E58C2294113B51" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K708</accession>
    <name>A0A118K708_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine-rich repeat, cysteine-containing subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000095">
        <property type="protein sequence ID" value="KVI11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K708"/>
    <dbReference type="STRING" id="59895.A0A118K708"/>
    <dbReference type="Gramene" id="KVI11522">
        <property type="protein sequence ID" value="KVI11522"/>
        <property type="gene ID" value="Ccrd_010066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15828" checksum="38DB85DD77627894" modified="2016-04-13" version="1" fragment="single">MNLVIVKHNLMNWLDLSQHIEIIPSDYLNVCFEDGDSKVATVGTSCLNCITLNFDSPRCQNLEYLDLYGCVNVTSRDIKNVASNLTIGSCRISDFKQMFLKKGICHTTHTMVDGGGGHGKVTTRCLRLCLFVFVYYNVCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K744</accession>
    <name>A0A118K744_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01000061">
        <property type="protein sequence ID" value="KVI11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K744"/>
    <dbReference type="STRING" id="59895.A0A118K744"/>
    <dbReference type="Gramene" id="KVI11640">
        <property type="protein sequence ID" value="KVI11640"/>
        <property type="gene ID" value="Ccrd_009943"/>
    </dbReference>
    <dbReference type="OMA" id="DLVYWAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000040">
        <property type="entry name" value="Nudix hydrolase 19, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="51973" checksum="618E9149DF290C77" modified="2016-04-13" version="1">MLFSCPLSSIHYISKSIFSVISRKPYFSTMSIHLKSPVFAGNPIRSKTPKSIDPFSPASAFQTLKVLLSGQSHLQEPSSPKFQVLPFRKGRPLAGSTGDLVKKWHLGWLTFADFKDVLEGTEVKLSDDLLVYLGCKTEKGEEEEEEDNVVYWAIDVSQGISLVEKLGSRQLTFVELRTLMVATDWADDAAMGELAIAGHARALLEWHNTSRFCGSCGEMLVPTEAGTRKQCIKDSCKKRIYPRVDPVVIMLVIDKENDCALLSKNTRFVPRMWSCLAGFIEPGESLEEAVRRETWEETGIQVGEVVYHSSQPWPVGPSSMPCQLMIGFLAYATSVEINVDKRELEDAKWYSREEVKKALTFAEYEKAQRTSAYKVDQMCKGVEKGQSLAADFNVESGELATMFVPGPFAIAHHLISSWAHQVSENGISTQTKGLILKSFHGDDADKQFLILKSSQVLKKKILVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S9R7</accession>
    <name>A0A124S9R7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="9">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="9">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01006358">
        <property type="protein sequence ID" value="KVH85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124S9R7"/>
    <dbReference type="STRING" id="59895.A0A124S9R7"/>
    <dbReference type="Gramene" id="KVH85177">
        <property type="protein sequence ID" value="KVH85177"/>
        <property type="gene ID" value="Ccrd_025436"/>
    </dbReference>
    <dbReference type="OMA" id="DPFDQFR"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000006">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="211"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="541" mass="60657" checksum="B08EEAAE59B1348A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB64</accession>
    <name>A0A124SB64_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L18/L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005179">
        <property type="protein sequence ID" value="KVH89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SB64"/>
    <dbReference type="Gramene" id="KVH89666">
        <property type="protein sequence ID" value="KVH89666"/>
        <property type="gene ID" value="Ccrd_008341"/>
    </dbReference>
    <dbReference type="OMA" id="MIVRCTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7338" checksum="DF375CC0D6C0DB91" modified="2016-04-13" version="1">MRNSSLCIYSTSGMTGFRDVAKKVGEAIAKLCMEKGITTVAFDRGGYPYHGRIQALXDAAREHGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCX2</accession>
    <name>A0A124SCX2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor IIS, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCX2"/>
    <dbReference type="STRING" id="59895.A0A124SCX2"/>
    <dbReference type="Gramene" id="KVH95156">
        <property type="protein sequence ID" value="KVH95156"/>
        <property type="gene ID" value="Ccrd_002766"/>
    </dbReference>
    <dbReference type="OMA" id="PVDEDWG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044204">
        <property type="entry name" value="IWS1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47350">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47350:SF4">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="451"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="653" mass="73607" checksum="4350EB5B1B4F077F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDD3</accession>
    <name>A0A124SDD3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004267">
        <property type="protein sequence ID" value="KVH96596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDD3"/>
    <dbReference type="STRING" id="59895.A0A124SDD3"/>
    <dbReference type="Gramene" id="KVH96596">
        <property type="protein sequence ID" value="KVH96596"/>
        <property type="gene ID" value="Ccrd_001306"/>
    </dbReference>
    <dbReference type="OMA" id="PKPWVLR"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000040">
        <property type="entry name" value="D6-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000060">
        <property type="entry name" value="D6-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="34210" checksum="76FCB140B2105F92" modified="2016-04-13" version="1">MEFDLENPFTKDLQHSLFAMESDHLPLSNSDLDSDHDIRRQIISFISSFSQKLHHPFVSYLAINYLHRFLASHSIPGEKPWILKLVAVSCVSLAFKMIGADSGLSDVQKDGELMFDFRMVERMEFLVLGALQWRMRSITPFAFIRFFVSFFKLKATSLHSDDADHHHHQVLKDRATEIIYKAQIESKLLEFKPSIVAASALLCASHELYPLQFPFFKNSISSCSYVNEDDFSKCYSEIQELVLDGYESMLSCKTPINVLDLDYSSSEDTHNKTAPSAEEKKGLKRLKISTFSKSPFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDF7</accession>
    <name>A0A124SDF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-binding FH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004192">
        <property type="protein sequence ID" value="KVH96775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDF7"/>
    <dbReference type="STRING" id="59895.A0A124SDF7"/>
    <dbReference type="Gramene" id="KVH96775">
        <property type="protein sequence ID" value="KVH96775"/>
        <property type="gene ID" value="Ccrd_001129"/>
    </dbReference>
    <dbReference type="OMA" id="MPATYKS"/>
    <dbReference type="OrthoDB" id="1922539at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072699">
        <property type="term" value="P:protein localization to cortical microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF18">
        <property type="entry name" value="OS01G0651932 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="606" mass="68056" checksum="B732948A4BF135FC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDX3</accession>
    <name>A0A124SDX3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003802">
        <property type="protein sequence ID" value="KVH98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDX3"/>
    <dbReference type="Gramene" id="KVH98307">
        <property type="protein sequence ID" value="KVH98307"/>
        <property type="gene ID" value="Ccrd_023460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13346" checksum="3F172227F444146E" modified="2016-04-13" version="1">MGFLASSDKIFGLTKQSETISTILNSLSCLLVIIRGSSSNSSESQTSDNQFSSRPTRLREQIGTGRSRQASPELTAASDENQKSARRLERFSTLKWRFSNDSRKSDDSRTILICYMAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEH8</accession>
    <name>A0A124SEH8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEH8"/>
    <dbReference type="STRING" id="59895.A0A124SEH8"/>
    <dbReference type="Gramene" id="KVI00166">
        <property type="protein sequence ID" value="KVI00166"/>
        <property type="gene ID" value="Ccrd_021627"/>
    </dbReference>
    <dbReference type="OMA" id="EYMLEEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138">
        <property type="entry name" value="OS01G0690200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138:SF87">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE, GALACTURONAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase C-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="7">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="49651" checksum="744798B26979EE8B" modified="2016-04-13" version="1">MAINKIQNHMLNELVDKSIGFETDDFVRRTATLVAELAFRCLQQEGDMRPTMKEVVEILRGIENDEWNIQKPEVLDIVVDDGGLFKDQNTEPPSPDYGVTNRLVDDSITNSSDASSSRSAGFYGTCNGSFSCGNLSGFRYPFRRHQDPAYCGYPGFELNCDGKNPPTIEIMKIMYRVLGVDPTAQILTVVREDMVNSICPQDLVNTTIDHELFDYTSSYMNISFLFGCPFSFDLVGFGSIFCSVEEVSPVFLMPGIQAPGICKTSVIIPVPVGFTNPSGLSQVLQKGFEVRWKVGPKPCNDCTQSGGQCIYDSATSLTSCACIETPILVESCSTVNKTGAEPMMHETRVVAMSSFVEQWKLEYLFWGVNSLNYCGKLGYKVDCVNQSIPVIEIKSLKHRVFEVNYHTQTITVARLDYWREICPSKLVNTTIDFEFFNYTFGIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFU1</accession>
    <name>A0A124SFU1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AT3G52170-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002210">
        <property type="protein sequence ID" value="KVI04351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFU1"/>
    <dbReference type="STRING" id="59895.A0A124SFU1"/>
    <dbReference type="Gramene" id="KVI04351">
        <property type="protein sequence ID" value="KVI04351"/>
        <property type="gene ID" value="Ccrd_017338"/>
    </dbReference>
    <dbReference type="OMA" id="CLEHECE"/>
    <dbReference type="OrthoDB" id="1930826at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058942">
        <property type="entry name" value="AT3G52170-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058941">
        <property type="entry name" value="HTH_AT3G52170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34568:SF4">
        <property type="entry name" value="OS02G0638000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34568">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25896">
        <property type="entry name" value="HTH_AT3G52170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AT3G52170-like helix-turn-helix" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="280" mass="31456" checksum="F758D3E8081D8C59" modified="2016-04-13" version="1">MPIVKGFRRFQSNIVFSRTVVTEISNLVPGSNVQQSGRSSVAPFTSKRPIKKKVTSADRKAMLESFVSKYRAMNMGKFPPPTSAQKEVGGSYYLIKKMLQEMEYNFKISSLEKGIGKENKKQTKGEDTVSSEIAIEPSGSQEVSTSQITTDQQLYKDAWPESVGNFDTNFKSKEVLQPSTSSANTGNSTTRDDTNYIAMEGHDRRGPCHEKPENNVKDDSPLENFGFEGSESKVEQQHDGMRNIMRNMAERQKDEELTVKASIWGNLKSLATNFINIWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGG3</accession>
    <name>A0A124SGG3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001838">
        <property type="protein sequence ID" value="KVI06316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGG3"/>
    <dbReference type="STRING" id="59895.A0A124SGG3"/>
    <dbReference type="Gramene" id="KVI06316">
        <property type="protein sequence ID" value="KVI06316"/>
        <property type="gene ID" value="Ccrd_015342"/>
    </dbReference>
    <dbReference type="OMA" id="LESWICD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF63">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="3">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="575" mass="63891" checksum="A95C88B0204F3E42" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHC1</accession>
    <name>A0A124SHC1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001071">
        <property type="protein sequence ID" value="KVI09073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHC1"/>
    <dbReference type="STRING" id="59895.A0A124SHC1"/>
    <dbReference type="Gramene" id="KVI09073">
        <property type="protein sequence ID" value="KVI09073"/>
        <property type="gene ID" value="Ccrd_012552"/>
    </dbReference>
    <dbReference type="OMA" id="STWSEKD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14342" checksum="AB865469D69B26B6" modified="2016-04-13" version="1">MEYLAAGTRPGFCQLQESHGLYVTCFNQHKHGKDHVVIPYPAQGHVIPLMEFAQHLIKYGIKVTPFINTEVTHKLVTSTWSEKDDFSDLMQMVSIPGGLEPWDDRNNLGKQVEAIFQYMPAKLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D948</accession>
    <name>A0A103D948_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011429">
        <property type="protein sequence ID" value="KVE00095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D948"/>
    <dbReference type="STRING" id="59895.A0A103D948"/>
    <dbReference type="Gramene" id="KVE00095">
        <property type="protein sequence ID" value="KVE00095"/>
        <property type="gene ID" value="Ccrd_024103"/>
    </dbReference>
    <dbReference type="OMA" id="NTHGRIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVE00095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="73" mass="8215" checksum="9F8A235D11805B8D" modified="2016-04-13" version="1" fragment="single">MAAPAMVRNMQVLFKNYIDGFPKESDMVVSSDATISLKLPKNESGVVLTKNLYLSCDPMMRNRMTESYLGAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103R213</accession>
    <name>A0A103R213_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_026336</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sterol desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007912">
        <property type="protein sequence ID" value="KVG59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103R213"/>
    <dbReference type="STRING" id="59895.A0A103R213"/>
    <dbReference type="Gramene" id="KVG59777">
        <property type="protein sequence ID" value="KVG59777"/>
        <property type="gene ID" value="Ccrd_026336"/>
    </dbReference>
    <dbReference type="OMA" id="FWEMGHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="16">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVG59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="29390" checksum="0B157E10EBBC40C7" modified="2016-04-13" version="1">MDSARLAIYLKIIKETLLVHHSHTTTETPATAFFHRNKAGFEMVAQEFTVDLDKPLVGHLGESYQEWVHQPIVSKEGPRFFKSDFWEMGHTLPQIAIILVMGIFVWSLLEYTLHRFLFHIKTKSYWGNTLHYLLHGCHHKHPQDGLRLVFPPTATAILLVPFWHFVKLISTPTVAPALFGGGLLGYVMYDVTHYYLHHGQPRNQVPKNLKKYHLNHHFRIQNKGFGITSSFWDKVFGTYPESKSVEKEKMMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SQT3</accession>
    <name>A0A103SQT3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007423">
        <property type="protein sequence ID" value="KVG91779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SQT3"/>
    <dbReference type="STRING" id="59895.A0A103SQT3"/>
    <dbReference type="Gramene" id="KVG91779">
        <property type="protein sequence ID" value="KVG91779"/>
        <property type="gene ID" value="Ccrd_026109"/>
    </dbReference>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG91779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="551" mass="63863" checksum="5E56634279BAF63D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB98</accession>
    <name>A0A103XB98_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein family Ycf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006077">
        <property type="protein sequence ID" value="KVH87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB98"/>
    <dbReference type="Gramene" id="KVH87546">
        <property type="protein sequence ID" value="KVH87546"/>
        <property type="gene ID" value="Ccrd_025175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056777">
        <property type="entry name" value="Ycf2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05695">
        <property type="entry name" value="Ycf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ycf2 N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="70" mass="8123" checksum="26C2CFE1A8CFF39A" modified="2016-04-13" version="1">MRELGLFASSEEEQEQERQDVVGSNAVNDGEDALDDDIVGNEDSEYYTLINQREIQQLKERSPLWDPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCF1</accession>
    <name>A0A103XCF1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005545">
        <property type="protein sequence ID" value="KVH88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCF1"/>
    <dbReference type="STRING" id="59895.A0A103XCF1"/>
    <dbReference type="Gramene" id="KVH88163">
        <property type="protein sequence ID" value="KVH88163"/>
        <property type="gene ID" value="Ccrd_024449"/>
    </dbReference>
    <dbReference type="OMA" id="LDESLWW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14131" checksum="D05CD5F996AA990E" modified="2016-04-13" version="1" fragment="single">MATTKSVNASLWWEPFTDLLTELENLSTSSELPISLANKLKENHSWLLDSVSLFKPSNQKSREALDFQHVQIGSHHLTIQPKLKELAMKISSSLCLDEVQSYILVERSCEHDTYDLVVLEPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCT5</accession>
    <name>A0A103XCT5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005431">
        <property type="protein sequence ID" value="KVH88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCT5"/>
    <dbReference type="STRING" id="59895.A0A103XCT5"/>
    <dbReference type="Gramene" id="KVH88378">
        <property type="protein sequence ID" value="KVH88378"/>
        <property type="gene ID" value="Ccrd_023982"/>
    </dbReference>
    <dbReference type="OMA" id="QLIRIHM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF4">
        <property type="entry name" value="OS01G0751300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="211"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="399" mass="44331" checksum="CDC632F607315A9C" modified="2016-04-13" version="1" fragment="single">QLSSGIKPINPADPPLIDRRFSFPFSTILPLFASTHIYLFIDSNSLCMYVCMYECIGGDKGTGAACLRSEMMIVELEQPGCYSKALVAVNLALAFIDCVIAVLAYYQLMRIHSRTPHRGWTRQKVFHLMIGFSNTALPKILFLAAFLLLLSFWVDLCHQANNEDEDEGSPQEALVEKANKPNLKVNRRRRCCTFRVFSVGSRQQVVILVTLLIFVIMLASAALIWIGLGKNPIDSAVVARVYVDIFAVAMLLLGGALACYGYVLVSKMSKVRSERASSEMWKVAGLAMVSVLCFTTSSVVAVFTNIPVLYHCGWRSIGGIYASLLLILYYLIGSSIPSAFVLWIMRELPPSVAINVPEESRTLTFVSDYSATTQPQHWTTITTAQNQVMHQEKAICIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD52</accession>
    <name>A0A103XD52_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005371">
        <property type="protein sequence ID" value="KVH88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD52"/>
    <dbReference type="Gramene" id="KVH88560">
        <property type="protein sequence ID" value="KVH88560"/>
        <property type="gene ID" value="Ccrd_026479"/>
    </dbReference>
    <dbReference type="OMA" id="VDVEYYP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF11">
        <property type="entry name" value="LIPASE YOR059C ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="440" mass="48035" checksum="6E8579209C79A7D0" modified="2016-04-13" version="1">MPYIQMASSASLLHYATPPLLNLRRTASLGPSPSNSNPNSPSSSSSSCSSSSSWPCCQGFSWTFSNCFGINGIWKHHILRAQAMSTTQGNLTSPRCANGVKDEPDHLLVLVHGIYASSSNTYSKTFAGIDGAGKRLADEVKQIVTSTESLKKISFLAHSLGGLIARYAVGVLYTHNASSIDNADDTTDSILNASGHRMIAGLEAINFITLATPHLGVRGNKQLPFLLGVPILEKIAAPMAPMFVGRTGSQLFLTDGKPNKPPLLLRMTTDCEEGNFISALGAFRYRILYANASYDHMVGRRTSSIRRESELVKPPFESLDGYKHVVDVEYCPPVLSTGSNFPPEAARAKEAAQNVPNTQNTLEYHEIMEEEMIRGLQRLGWKKVDVSFHTSLWPFFAHNNIHVKDEWFHKAGAGVVAHVADSIMQQEKQHQSSSFISASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD54</accession>
    <name>A0A103XD54_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005392">
        <property type="protein sequence ID" value="KVH88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD54"/>
    <dbReference type="Gramene" id="KVH88491">
        <property type="protein sequence ID" value="KVH88491"/>
        <property type="gene ID" value="Ccrd_026693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF325">
        <property type="entry name" value="NB-ARC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53621" checksum="A962F26407B8D89C" modified="2016-04-13" version="1">MRMVREEERNMQKAFEADSLAKMDNLKLLQLNYVELNGSYDEFPEDLRWLCWHGFHLGTVPSELFMGNLVAIDMSYSKLRIFEPPMVIRPLKILNFKDSHSLEEIRNISRLPNLETLILWNCYSLVRVCETIQGLTSLALLNMTGCEQLLKMEHIDPSEGLKASDYGGQSPQQPLFFFPHSLERLLLKSCNLERNNSFLLSFQVQSFLQYLHLGSNLFEFLPDYNHLKSLRMLYEFGIMSVFLPDIKDPNISCEYASQSSPLSFDVPSPPKNHRLKGIDVKFKYTTSGQEKHVGPIFAKISNTTKGHDWIYNPMIFGRPGIGEVAIWLSYWAMEKVLDVGDKVNVSIIVENGLKVHECGASLVYANDKVENDTWHNNMEWEKILVDYLSAFQLSTKTYYLCRRDFFKSMEVDGPTPSWFRDAVGNNIDYTVIIFTVLESSGSRFRINDAYGLATGQIQDAVASFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEE5</accession>
    <name>A0A103XEE5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005310">
        <property type="protein sequence ID" value="KVH89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEE5"/>
    <dbReference type="Gramene" id="KVH89114">
        <property type="protein sequence ID" value="KVH89114"/>
        <property type="gene ID" value="Ccrd_008900"/>
    </dbReference>
    <dbReference type="OMA" id="GITAWFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF108">
        <property type="entry name" value="O-GLUCOSYLTRANSFERASE RUMI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="138"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="53143" checksum="F9B3B17E393ECA8E" modified="2016-04-13" version="1">MSGVILKNTGVHVSAFVSVFLVTLFITAVFFTRWVDVSALTAQFRQKDILPSADRGNISDLTPESCPEYFRWIHEDLKPWKETGVTKEMVEKAREKAHFRLIIVDGRLYMEKYDYVFQTRDVFTIWGIQQLLELYPGKVPDLDLMFMCHDWPLILKANYPDNTSVIPPLFHYCGDDLTYDIVFPDWSFWGWPEVNIMPWVKLKKELEEGNQRKKWKEREPYAYWKGNTHTGSARKDLAKCNSDGKQEWNARIHHLDWGKGFKDTNLASQCTHRYKIYVEGNAWSVSEKYILACDSMSLVITPHYYDFFTRGLIPTVHYWPINEHKKCSSIKFAVDWGNKNTKKAQKIGRTGSRFIQNELQMKFVYDYMLHLLTEYSKLFKYKPVITKNAVEVCSCFGKGLVKEFKELSKETGPSKADPCAMHPPFEDFEIQSLHEKKLNLTRQVEIWEESQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEK1</accession>
    <name>A0A103XEK1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005294">
        <property type="protein sequence ID" value="KVH89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEK1"/>
    <dbReference type="STRING" id="59895.A0A103XEK1"/>
    <dbReference type="Gramene" id="KVH89204">
        <property type="protein sequence ID" value="KVH89204"/>
        <property type="gene ID" value="Ccrd_008811"/>
    </dbReference>
    <dbReference type="OMA" id="MYLEAQC"/>
    <dbReference type="OrthoDB" id="1430376at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051955">
        <property type="entry name" value="PME_Inhibitor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080:SF12">
        <property type="entry name" value="PLANT INVERTASE_PECTIN METHYLESTERASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118722" evidence="2">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="3">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="22609" checksum="D6D6907DDFE4C578" modified="2016-04-13" version="1">MAQIILSFMVLSLTFFGFSATVESRSSARVYLEAQCRSVVYHDLCVKTLLPYVGKAVPGPQQLARISMAVCLSKARLTKAYVNMVAKKFNQTKNFGDYQAVDACLNQISNGVNQITLSVKEFQKMGKDGEQNFMLHEGNVQSWVSAALTDADMCVDGLLGNGIGGRDKAMIKTMILNVKQLASNSLGLFNRFTMRHRASRIVKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF91</accession>
    <name>A0A103XF91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005196">
        <property type="protein sequence ID" value="KVH89579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF91"/>
    <dbReference type="STRING" id="59895.A0A103XF91"/>
    <dbReference type="Gramene" id="KVH89579">
        <property type="protein sequence ID" value="KVH89579"/>
        <property type="gene ID" value="Ccrd_008413"/>
    </dbReference>
    <dbReference type="OMA" id="TECFLEQ"/>
    <dbReference type="OrthoDB" id="1938580at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000058">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053198">
        <property type="entry name" value="Gynoecium_Dev_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066">
        <property type="entry name" value="OS05G0427100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066:SF33">
        <property type="entry name" value="OS07G0556300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="427" mass="46741" checksum="4EA1121D380E086A" modified="2016-04-13" version="1">MTTTHYTAEQQLSVTVDSVASSPRSDHPPSDGRIYDDTTAQARVRFMCSFGGKILPRPHDNQLRYVGGDTRIVTVLRHNTTFSALLNKLSKLSGTSDICVKYQLPNEDLDALITVTSDEDVENMLDEYDRLAHNHKTARLRLFLFPTDASLSRATSISSLLDGSIKREHWFLDALNGGASLERGRSEVSSIISEVPDYLFGLDHTDDTKPKTRPGVVNDNVSVSDPGSPAPRISSPYCSTSSSLGPTVAPPVPNLRPVRTKLDNPSSVVTEPKETGTEHFSEANDPIILKQTEYAGQQMYYMRRTSSPAPMQEMPVYYMQPPGSMPQENVPLQSLPIRAQYGQQFMTPQGQILHPQVSNMGQMYSGMRPVSGGEAYEMPGRGGGGPGQPVYYGPRYVGVPGYPGMVLPGGEEMKQPGSETKMGRAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFW3</accession>
    <name>A0A103XFW3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_008020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005120">
        <property type="protein sequence ID" value="KVH89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFW3"/>
    <dbReference type="Gramene" id="KVH89990">
        <property type="protein sequence ID" value="KVH89990"/>
        <property type="gene ID" value="Ccrd_008020"/>
    </dbReference>
    <dbReference type="OMA" id="VEMPLCK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF23">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RHA4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="226" mass="25126" checksum="8BD00D1BC3E08305" modified="2016-04-13" version="1">MGYLQSSSASTGANSHLYSQALQMKLYQAFIFSIPILFSIILFLLFYLFYLKRTFSSTHSSSSSASILPSRNQDSSTLPQYSEMGLKINLEDRLTVILFDEDLYAKDSMCCVCLGEFEMNEKLHQIPACQHVFHGDCIRNWIHSNTTCPLCRCSVISAAAKDGHHEPLVVPDQPTTAINLSSNPQGVPLEHSVIIFEGSSSSSMDDNKLCHPIEESVVVTVRIHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGV9</accession>
    <name>A0A103XGV9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGV9"/>
    <dbReference type="STRING" id="59895.A0A103XGV9"/>
    <dbReference type="Gramene" id="KVH90525">
        <property type="protein sequence ID" value="KVH90525"/>
        <property type="gene ID" value="Ccrd_007437"/>
    </dbReference>
    <dbReference type="OMA" id="KEIHDSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF190">
        <property type="entry name" value="OS09G0453300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35630" checksum="27A317C767B72BD2" modified="2016-04-13" version="1">MAKPLSQSSIEDICKQIHGSLGNFSLLVRVFAGQLTQHECQKTRERYMEMYGEDLFDRLRNKIDGQASKTCMVLSSLMLSPHERDAIVANNAIFKQRGSVNYKALIEIYVGRKSSHFFLIQQAYQTKFRRHLDQDMLMALAASQKAHSAEVSVHIGKCDAQRLFQTGEARPGGFKIDEGVVLEILSKRSIPQLNLTFSIYKHIYGHSYTKHFKNKYDGEFEAALKFVVKFLNNPPKYYAKELEASIKGRKNDEGDLERIMMSRSEIDMNKIRKNYKNKYGMDLRDAIMENVPVGDFRDSIMALTSKTSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK46</accession>
    <name>A0A103XK46_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004828">
        <property type="protein sequence ID" value="KVH92251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK46"/>
    <dbReference type="STRING" id="59895.A0A103XK46"/>
    <dbReference type="Gramene" id="KVH92251">
        <property type="protein sequence ID" value="KVH92251"/>
        <property type="gene ID" value="Ccrd_005715"/>
    </dbReference>
    <dbReference type="OMA" id="GAIQDMG"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF303">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="39257" checksum="1340A3C6CB45DC43" modified="2016-04-13" version="1">MSLDNITPSKQPNKDETQTSAGGGGGGGGGGRKASILKPPEQTLKCPRCDSPNTKFCYYNNYSLTQPRYFCKTCRRYWTRGGALRNVPIGGGCRKNKKTRVSSSRYVNGDSSSKDSSLDIGGLSLLSGPSPPAMDFQFAGINNNINIPPRLNHFSSSFGDLSNNPPPFINLDSLGFNFPSMKQDHHHHQPHGGLSNFQGMGVADNLHLNPTTNLASSIESLSSINQDLHWRLQQQRLATLLGGTGSDDGGGGGGAGGEPDQQQQQNQIAIESQSQKLQPILFHNLEIPKPSMSSDVRKDGSGSGGGLETEWFFDNNYAPVNVNPSTEMAPADINTAGNYQIGSINNWNIGMQAWNQFNQYSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK95</accession>
    <name>A0A103XK95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004824">
        <property type="protein sequence ID" value="KVH92313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK95"/>
    <dbReference type="STRING" id="59895.A0A103XK95"/>
    <dbReference type="Gramene" id="KVH92313">
        <property type="protein sequence ID" value="KVH92313"/>
        <property type="gene ID" value="Ccrd_005661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11446">
        <property type="entry name" value="bHLH_AtILR3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044579">
        <property type="entry name" value="bHLH11/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057075">
        <property type="entry name" value="bHLH_IRO3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47001:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47001">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23177">
        <property type="entry name" value="bHLH_IRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="255" mass="28510" checksum="4E808A26F5D56F9C" modified="2016-04-13" version="1">MDQWKTKLELHQHQHIPNSCTEHREMTEVEAKDTSDARKVQKADREKLRRDRLNEQFIELGNVLDPERPKNDKASIIIDTIQVLKDLATEVNRLKADCAALSEESSELTQEKNELREEKSSLKSDIENLNAQYQQRVGVMYPWAAIDPSSVVMPPPYSYPVALPVPSGPVPMHPFPFFTNHNPPGAIPTSSPAFMSYPNLPTAHINQTIPVYALTSHSSSKQECGSKSSDRFRGSNDEKGDHSSNVGGKVNIGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLK2</accession>
    <name>A0A103XLK2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLK2"/>
    <dbReference type="STRING" id="59895.A0A103XLK2"/>
    <dbReference type="Gramene" id="KVH92774">
        <property type="protein sequence ID" value="KVH92774"/>
        <property type="gene ID" value="Ccrd_005092"/>
    </dbReference>
    <dbReference type="OMA" id="YTWHSQV"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="28187" checksum="290BDE05B418FEA7" modified="2016-04-13" version="1">MAMVRVAPLARLRLAPMKRRRFYGSAAQLQCDYDDEYDYKESFSGTEEDSLGSVSGRGVQWVIMGDPLTNRHMYAERLSQLLKVPHISMGTLVRQQLHPRSSLYKQIADAVNQRKLVPEEVIFGLLSKRLEEGFYRGETGFILDGIPRTRMQAEILDQVADIDLVLNFKCTEECLQKKHVGGQACASYQDFLNGRDSMKNALEEYYKKQKKLLNFNVGGAPGETWQGLLAALHLQHMNALSSCSHKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM14</accession>
    <name>A0A103XM14_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MORF/ORRM1/DAG-like MORF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004794">
        <property type="protein sequence ID" value="KVH93135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM14"/>
    <dbReference type="STRING" id="59895.A0A103XM14"/>
    <dbReference type="Gramene" id="KVH93135">
        <property type="protein sequence ID" value="KVH93135"/>
        <property type="gene ID" value="Ccrd_004843"/>
    </dbReference>
    <dbReference type="OMA" id="NHWLITI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016554">
        <property type="term" value="P:cytidine to uridine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080156">
        <property type="term" value="P:mitochondrial mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039206">
        <property type="entry name" value="MORF/ORRM1/DAG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054059">
        <property type="entry name" value="MORF/ORRM1/DAG-like_MORF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31346">
        <property type="entry name" value="MULTIPLE ORGANELLAR RNA EDITING FACTOR 2, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31346:SF4">
        <property type="entry name" value="MULTIPLE ORGANELLAR RNA EDITING FACTOR 8, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21864">
        <property type="entry name" value="MORF_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="MORF/ORRM1/DAG-like MORF" evidence="3">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="32100" checksum="EE287B37B5110F2E" modified="2016-04-13" version="1">MATRVLLRSLISTANQTLITRFYTTTSSPVLRIRPLVAAANNLRHCSLVATRSRAFSTRQTTSSLNDSNPNWSNRPPKETILLDGCDFEHWLVVVEKPEGEPTRDEIIDSYINTLAKVVGRMKIYSVSTRCYYAFGALVSEEDSYKIKELPGVRWVLPDSYLDVKNKDYGGEPFIDGKAVPYDPKYHEEWIRNNARANERNRRNDRPRNFDRSRNFERRRENMQSNRPSPGGAMGGPPNNMGGPPNAGGAPSGNMGGPPNAGGAPYGNMGGPPNAGGAWCTIWKHGWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM92</accession>
    <name>A0A103XM92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004779">
        <property type="protein sequence ID" value="KVH93335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM92"/>
    <dbReference type="STRING" id="59895.A0A103XM92"/>
    <dbReference type="Gramene" id="KVH93335">
        <property type="protein sequence ID" value="KVH93335"/>
        <property type="gene ID" value="Ccrd_004620"/>
    </dbReference>
    <dbReference type="OMA" id="ARCEETS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36325">
        <property type="entry name" value="MYOSIN-2 HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36325:SF1">
        <property type="entry name" value="MYOSIN-2 HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="644" mass="72313" checksum="E9939F70E585EADD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMJ5</accession>
    <name>A0A103XMJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_004709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004790">
        <property type="protein sequence ID" value="KVH93239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMJ5"/>
    <dbReference type="Gramene" id="KVH93239">
        <property type="protein sequence ID" value="KVH93239"/>
        <property type="gene ID" value="Ccrd_004709"/>
    </dbReference>
    <dbReference type="OMA" id="QLMGWLT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF424">
        <property type="entry name" value="POLYOL TRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="38"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH93239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="463" mass="50307" checksum="C8C6AC700C6B0390" modified="2016-04-13" version="1" fragment="single">MADRKPEQNSGFDKPNKLAITEFDPPKPPKRNKYAFACAMLASMTSVLLGYDIGVMSGVQIYIKRDLDCSDTQIEILVGILNLYSLVGSAAAGKTSDWIGRRYTIVFAGAIFFVGAILMGFATNYAFLMVGRFVAGIGVGYALMIAPVYTAELPLHLGWRLMLGIGAVPSIFLALGVLGMPESPRWLVTQGRLGDAKIVLDKTSDSLEESKLRLADIKEAAGIPEDCNDDVVQVPKRNHGEGIWRELLVHPTPTVRHILIAAVGIHFFQQASGIDAVVLYSPKIFEKAGIVKDTPKLLATIAVGFVKTIFILVATFFLDKVGRRPLLLSSVAGMIVSLMGLGVGLTVVDHYDHKISWAIAFSIAMTLSYVAFFSIGMGPITWVYSSEIFPLRLRAQGCSMGVAMNRVVSGVISMSFLSLSKGITFGGAFFLFTGIAMVAFVFFFTLFPETQGRNLEEVEQLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN51</accession>
    <name>A0A103XN51_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coactivator CBP, KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004599">
        <property type="protein sequence ID" value="KVH93797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN51"/>
    <dbReference type="STRING" id="59895.A0A103XN51"/>
    <dbReference type="Gramene" id="KVH93797">
        <property type="protein sequence ID" value="KVH93797"/>
        <property type="gene ID" value="Ccrd_004148"/>
    </dbReference>
    <dbReference type="OMA" id="HENHGSA"/>
    <dbReference type="OrthoDB" id="1937968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35300">
        <property type="entry name" value="COACTIVATOR CBP, KIX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35300:SF4">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41771" checksum="1E9C3E930BB24F64" modified="2016-04-13" version="1">MPRPGPRPFECVKRSWHSDRHQPIRGSIIQQIFRVVQENHALGTKKNREWQEKLPLVVFKSEEIMYSKANSEAEYVDPETLWDRLNDAIDTIIRKDESMETGELLPPCVEAALNLGCVPVRSSRSQRNSNTRSYLTPRNQDSGPTPARTMPTATNARNLNVPNVQRPDGMDWTHTFSESNKDLRPNFKVTPSGSSFYPPSFENLPRKMVSFENRASSSYPLYHGFHFQPRVPQMGFCSTHHNSNNIIVGTPVFQPSFQKGCSERLFTFDRDDNGSKKETRPELAECDLSLRLGLVSSNGKESTCVDDVDSGSGSKEFSFFPLNSEAEEVQDLVTGVRKRKTVGEPQQFLQLDPDFNQIKERMKRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNK5</accession>
    <name>A0A103XNK5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004586">
        <property type="protein sequence ID" value="KVH93913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNK5"/>
    <dbReference type="STRING" id="59895.A0A103XNK5"/>
    <dbReference type="Gramene" id="KVH93913">
        <property type="protein sequence ID" value="KVH93913"/>
        <property type="gene ID" value="Ccrd_004033"/>
    </dbReference>
    <dbReference type="OMA" id="CMATRRN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="16875" checksum="691945D342590BD7" modified="2016-04-13" version="1" fragment="single">MVGGNNSKNIQAKLVLSINKSSVKFDIWDTAGQERYHSLAPMYYRGAAAAVVIYGITTMVSFQRAKKWIEELQRQGDPHLVKVLVANKADLDTKREVQIEEGKRYAIENGLHFFETSAKTGENINELFYEIAKRVAQAAPSNPSGMKLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP57</accession>
    <name>A0A103XP57_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP57"/>
    <dbReference type="STRING" id="59895.A0A103XP57"/>
    <dbReference type="Gramene" id="KVH94356">
        <property type="protein sequence ID" value="KVH94356"/>
        <property type="gene ID" value="Ccrd_003581"/>
    </dbReference>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="468"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="501"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="594" mass="64646" checksum="BD13966ED18A9AA2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRD6</accession>
    <name>A0A103XRD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L18/L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004387">
        <property type="protein sequence ID" value="KVH95478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRD6"/>
    <dbReference type="STRING" id="59895.A0A103XRD6"/>
    <dbReference type="Gramene" id="KVH95478">
        <property type="protein sequence ID" value="KVH95478"/>
        <property type="gene ID" value="Ccrd_002449"/>
    </dbReference>
    <dbReference type="OMA" id="SASITHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000004">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF5">
        <property type="entry name" value="RIBOSOMAL L18P_L5E FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="11403" checksum="7DDC9F3F48B820F7" modified="2016-04-13" version="1">MEPFTLDVFISKRFVSASLTHRVTSKQVAVAGTNSKDIKAALKSRSDIPACLAIGKILSERAREADVYTASYTPRERDKFEGKIRAVVQSLIDNGIDVKIYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRP1</accession>
    <name>A0A103XRP1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004380">
        <property type="protein sequence ID" value="KVH95648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRP1"/>
    <dbReference type="Gramene" id="KVH95648">
        <property type="protein sequence ID" value="KVH95648"/>
        <property type="gene ID" value="Ccrd_002262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="44" mass="4748" checksum="65C83E665B401A2A" modified="2016-04-13" version="1">MTTFFGMSLGAFVFWQSMILAGLLGSEVQLCGMTFLGVFGPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSE7</accession>
    <name>A0A103XSE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004364">
        <property type="protein sequence ID" value="KVH96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSE7"/>
    <dbReference type="Gramene" id="KVH96038">
        <property type="protein sequence ID" value="KVH96038"/>
        <property type="gene ID" value="Ccrd_001881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="16699" checksum="09B191410F71323A" modified="2016-04-13" version="1">MAAALNIYWWYAAAANAPTNGPTQKIHCIYINPTKPSYSKRSTYLVIPHFFIVVNNSSTKAPSWVDPSSSNGYGGQMHHENSKPNWQWSQNLHKSTSFSARCTRNVRITCTPFRVSGREDSVNKDKGANNLSTKCSTLVVARCNGVGTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSF7</accession>
    <name>A0A103XSF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004364">
        <property type="protein sequence ID" value="KVH96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSF7"/>
    <dbReference type="STRING" id="59895.A0A103XSF7"/>
    <dbReference type="Gramene" id="KVH96035">
        <property type="protein sequence ID" value="KVH96035"/>
        <property type="gene ID" value="Ccrd_001884"/>
    </dbReference>
    <dbReference type="OMA" id="VNPMFRV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36544" checksum="9A286751FD8FE7AB" modified="2016-04-13" version="1">MAKPVSIEVWNPSGKYRVVSTKSMPGTRWINLLVQQDCRVEICTEKKTILSVEDIIALIGNKCDGVIGQLTEDWGETLFSALSKAGGKAFSNMAVGYNNVDVEAATKYGVAVGNTPGVLTETTAELAASLSLAASRRIVEADGFMRAGLYDGWLPHLLKAYGQFLKASGEQPVTWKRASSMDEVLQVADVISLHPILDKTTYHLINKERLSKMKKEAILINCSRGPVVDEEALVEHLKQNPMFRVGLDVFEDEPYMKPGLADMKNAIVVPHIASASKWTREGMVTLAALNVLDCQFRSSKKGRQFSGVTTMYSFGLCTLCIAYAHYSMYVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSW8</accession>
    <name>A0A103XSW8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004338">
        <property type="protein sequence ID" value="KVH96271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSW8"/>
    <dbReference type="STRING" id="59895.A0A103XSW8"/>
    <dbReference type="Gramene" id="KVH96271">
        <property type="protein sequence ID" value="KVH96271"/>
        <property type="gene ID" value="Ccrd_001634"/>
    </dbReference>
    <dbReference type="OMA" id="XEEALNG"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000097">
        <property type="entry name" value="Chaperone protein dnaJ 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF8">
        <property type="entry name" value="DNAJ DOMAIN, CHAPERONE J-DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="45478" checksum="8E3BFBF7698182B2" modified="2016-04-13" version="1">MGGSKMEGGTSSSAAATAAAAPNRRDPYEVLNVSRDSSDQEIKSAYRKLALKYHPDKNASNPEASELFKEVAYSYNILSDPEKRRQYDNAGFEAIDADGTDMEIDLSNLGTVNTMFAALFSKLGVPIKTTISANVLEDALSGTVTVRPLPLGSSVSGKVEKQSAHFFGVTVTEEQAQAGIIVRVTSAAQSKFKLLYFEQDNGGGYNLALQEDSEKTGKVTSAGMYFLHFQVYRMDSSVNALAMAKDPDAAFFKRLEGLQPCEVSELKAGTHIFSVYGDNFFKTASYTIEALCAATYEGTTHKLKDIEQQILRKRTELRQFETEYRKALAQFQEVTNRYSQEKQNVDELLKQRDNIQSSFMVDRSVVFGSKVSNGGNSRVPGEDSSPGEDGKDKSTKKRWFNLNLKGSTDKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT23</accession>
    <name>A0A103XT23_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004326">
        <property type="protein sequence ID" value="KVH96349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT23"/>
    <dbReference type="Gramene" id="KVH96349">
        <property type="protein sequence ID" value="KVH96349"/>
        <property type="gene ID" value="Ccrd_001567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116:SF29">
        <property type="entry name" value="DNA GLYCOSYLASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116">
        <property type="entry name" value="OS04G0501200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="258" mass="28773" checksum="6F818DE0F64C0D2B" modified="2016-04-13" version="1">MSKENVKKYVEKKQKPSSTHSLLSKRLKKVYPFELKKTTSLLSLSSPSSTLLRNTSESFTISSSTVDQAISSALGLISPDTPPTAKTSMPVLVAVPVPIPVLQPNLVSDASNESVKRCNWISKASEKLYVQFHDECWGPIVRVAFVVGDANGLQLDRNSKTKGTFLIAKQHGSFSGYMWGCMNYKPTINRYKHPRNVPMRTPKAEAISKDLLKHGFRLVGPVIVYSFMQAAGMSIDHLVDCFRFDECVSLAERPWRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTA0</accession>
    <name>A0A103XTA0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase small chain, chloroplastic</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carbamoyl phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_001467</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004306">
        <property type="protein sequence ID" value="KVH96449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTA0"/>
    <dbReference type="STRING" id="59895.A0A103XTA0"/>
    <dbReference type="Gramene" id="KVH96449">
        <property type="protein sequence ID" value="KVH96449"/>
        <property type="gene ID" value="Ccrd_001467"/>
    </dbReference>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000034">
        <property type="entry name" value="carbamoyl-phosphate synthase small chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="17">
        <location>
            <begin position="52"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH96449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="46699" checksum="EFD257631AEDCFA4" modified="2016-04-13" version="1">MATKAMYLSVSHQSLLSIPATTKPLQVRSFTVRCSTGAAPVGAAVPAPWKLADARLVLQDGSIWKAKSFGASGTQVGEVVFNTSLTGYQEILTDPSYAGQFVLMTNPHIGNTGVNIDDEESIRCFLAGLVIRSLSISTSNWRCTESLSDYLSKRNIMGIYDVDTRAITRRLREDGSLIGVLSTEKSKTDEELLEMSRNWDIIGVDLISTVSCKKPYEWVGKTDMEWDFNSNGRDGKTFHVVAYDFGIKHNILRRLASYGCKITVVPSTWPASETLKMKPDGVLFSNGPGDPSAVPYAVETVKEIIGKVPVFGICMGHQLLGQALGGKTFKMKFGHHGGNHPVRNLRNGSVEISAQNHNYAVDPDSLPDGVEVTHVNLNDGSCAGLAFPQRKLMSLQYHPEASPGPHDSDMVFDHFMELMRREKQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU21</accession>
    <name>A0A103XU21_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TIC 214</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Translocon at the inner envelope membrane of chloroplasts 214</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the Tic complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIC214 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004080">
        <property type="protein sequence ID" value="KVH96917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU21"/>
    <dbReference type="STRING" id="59895.A0A103XU21"/>
    <dbReference type="Gramene" id="KVH96917">
        <property type="protein sequence ID" value="KVH96917"/>
        <property type="gene ID" value="Ccrd_000990"/>
    </dbReference>
    <dbReference type="OMA" id="MIIANFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042170">
        <property type="term" value="C:plastid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008896">
        <property type="entry name" value="TIC214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33163:SF40">
        <property type="entry name" value="PROTEIN TIC 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33163">
        <property type="entry name" value="PROTEIN TIC 214-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05758">
        <property type="entry name" value="Ycf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="77" mass="8570" checksum="C065FC9561D7938B" modified="2016-04-13" version="1">MEGNLVFLCMKIINSVGVVGLYYRFLTTFSIGPSYLFLLRAHVMEEGEEGISNNWFYYGTAHNVHIDLLCASASSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUK7</accession>
    <name>A0A103XUK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003852">
        <property type="protein sequence ID" value="KVH97154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUK7"/>
    <dbReference type="STRING" id="59895.A0A103XUK7"/>
    <dbReference type="Gramene" id="KVH97154">
        <property type="protein sequence ID" value="KVH97154"/>
        <property type="gene ID" value="Ccrd_000728"/>
    </dbReference>
    <dbReference type="OMA" id="VISNWRT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000009">
        <property type="entry name" value="oxysterol-binding protein-related protein 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF136">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="345" mass="38972" checksum="8442D8834F2335C1" modified="2016-04-13" version="1">MAQNQGGGGGFFSSLASSFSNFKNQVNGLLGYEGLEVINPEGGTEDAETEAQRGRWKQEDRDSYWKMMQKYVGADITSMVTLPVLIFEPMTMLQKMAEVSHHPPMSAAHAENEHFVYDITSKVKTKFLGNSLDVYPLGRTRLKLKKDGVILELVPPPTKVNNLIFGRTWVDSPGEMVLTNLTTGDKVVLYFQPCGWFGAGRYEVDGYVYNASEEPKILMTGKWNKSMSYQPCDLEGEPLPGTELKEVWRVAEAPANDKFHLEEKQRAEKRAREAKGQEFSPRWFEITEEVAPTPWGDLEIYQYNGKYSDHRAAVDSTSTFEDVDISTTEFNPWQYGNVAETEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUM2</accession>
    <name>A0A103XUM2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperonin Cpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a co-chaperone for protein folding in chloroplasts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003848">
        <property type="protein sequence ID" value="KVH97220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUM2"/>
    <dbReference type="STRING" id="59895.A0A103XUM2"/>
    <dbReference type="Gramene" id="KVH97220">
        <property type="protein sequence ID" value="KVH97220"/>
        <property type="gene ID" value="Ccrd_000672"/>
    </dbReference>
    <dbReference type="OMA" id="GRHCFCK"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000008">
        <property type="entry name" value="10 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF13">
        <property type="entry name" value="10 KDA CHAPERONIN 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH97220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15019" checksum="2D274FAD603D7E5F" modified="2016-04-13" version="1">MASSTFFTPTKPFLSFATDLPSPSISTKPTTLGLRRNSFKVNAIAAKYEPTKVKPQADRVLIRLEELPQKSAGGVLLPKSAVKFERYLMGEILAVGSEAGELEAGKKVLFSDINAYEVDLGAEGRHCFCKAADLLAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV05</accession>
    <name>A0A103XV05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAK-box/P21-Rho-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003833">
        <property type="protein sequence ID" value="KVH97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV05"/>
    <dbReference type="STRING" id="59895.A0A103XV05"/>
    <dbReference type="Gramene" id="KVH97401">
        <property type="protein sequence ID" value="KVH97401"/>
        <property type="gene ID" value="Ccrd_000505"/>
    </dbReference>
    <dbReference type="OMA" id="WSSQGCG"/>
    <dbReference type="OrthoDB" id="4206278at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000029">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325:SF20">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="15368" checksum="5D37A99E2B3E3547" modified="2016-04-13" version="1">MGTKIKGVFKGFKFISQIFVMKEREMEIGYPTDVKHVAHIGWDGSSGSAPSWMNEFKTAPDFAATSIGNSGSALSTWSSQDFGEAMGRRHTDDTINDLPPIDLPNIPKKQRRRKSKSTCSPKSSSSSKSSRKAKANIEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVJ3</accession>
    <name>A0A103XVJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003822">
        <property type="protein sequence ID" value="KVH97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH97671">
        <property type="protein sequence ID" value="KVH97671"/>
        <property type="gene ID" value="Ccrd_000229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051761">
        <property type="entry name" value="MLP-like_ligand-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31907">
        <property type="entry name" value="MLP-LIKE PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="289"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="446"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="650"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="804" mass="91161" checksum="6F1B0AE45E4D954B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWA2</accession>
    <name>A0A103XWA2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWA2"/>
    <dbReference type="STRING" id="59895.A0A103XWA2"/>
    <dbReference type="Gramene" id="KVH98072">
        <property type="protein sequence ID" value="KVH98072"/>
        <property type="gene ID" value="Ccrd_023686"/>
    </dbReference>
    <dbReference type="OMA" id="HSEHIMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="113"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="321" mass="35339" checksum="17A3CADA652D5D67" modified="2016-04-13" version="1">MYWSKCKYFKVSKDDRKTLLFLGRDGNEAGRVAGDGNEAGPVAGDGGCSKSAISMDAFTNLDAVDETISVEVKSFFDSAPLLKDADNISRKLTQFIDHNASLSGMFTSTGSRKVVCVTSGGTTVPLEQRCVRYIDNFSSGHRGATSTEYFLKAGYSVIFLYRRSLPEDLLLECFELTDDSCIQGLHESHSEAVKRAIRGHHAILGPSAMFYLAAAVSDFYVPWESMAMHKIQSSSGPLDMRLAQVPKMLLLETDKEILLEKADKALKRYKMNAVVANELSTRKEVVILVTDGGKVSVYRENDHADVESPLGLIILPNLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWA8</accession>
    <name>A0A103XWA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWA8"/>
    <dbReference type="Gramene" id="KVH98075">
        <property type="protein sequence ID" value="KVH98075"/>
        <property type="gene ID" value="Ccrd_023700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="30712" checksum="6964FBD1557BACD0" modified="2016-04-13" version="1">MTGGNLRLQSDARFLNGKMHIKYIRKRQLNATDLNLISFTSEIIAGTRGGLRFLRPPSTEIYSLPSDELAQRVVVGQEPSGQLDPQTVFVDHLGPESVAFSDPLVRMSSDCLNSRYLRRNSPAQTTVLFPVTAVQFLGYLRRRLSDHETLSGHETVLLSVTAEILGYFGHNQSGLDQTLPIPATAVLILGYLRCKLSGHQMVLLLVTAVLLVYLGRKTVVTVVLLLRLPSELPPAPPDAVVVDQILHICIHLPSKSPINKSYRERKSNEIMKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWF6</accession>
    <name>A0A103XWF6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWF6"/>
    <dbReference type="STRING" id="59895.A0A103XWF6"/>
    <dbReference type="Gramene" id="KVH98128">
        <property type="protein sequence ID" value="KVH98128"/>
        <property type="gene ID" value="Ccrd_023666"/>
    </dbReference>
    <dbReference type="OMA" id="NCDPQER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF93">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="63"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="294" mass="33689" checksum="6C947B673895F9E5" modified="2016-04-13" version="1" fragment="single">IKVSPYVPYVLSLKTPFSILVTTLSSLPCKCYRMSIEDNKRAENPKNGVKEKLSFVRDGSIKLPPGFRFQPTDQEIVFQYLVRKVFSCPLPASIIPEIVNICKFNPWDFPGEWEQERYFFSKKEAKYGHGNRVNRRSSDGYWKATGFDKHITRCCGNNSSSRKKDTITGMKKTLVFYKTNPSTTRTHWIMHEYRLVHSPPSPTTTSNDKKSWIQMGNWVLCHVLLNKRSRKPIEDDNGKKSDSTERQDLTRNDTNYKPASSSYSSSSSCGSSVVTLEVSSTKNQFDHEETNNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX88</accession>
    <name>A0A103XX88_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003786">
        <property type="protein sequence ID" value="KVH98603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX88"/>
    <dbReference type="STRING" id="59895.A0A103XX88"/>
    <dbReference type="Gramene" id="KVH98603">
        <property type="protein sequence ID" value="KVH98603"/>
        <property type="gene ID" value="Ccrd_023179"/>
    </dbReference>
    <dbReference type="OMA" id="CKLTESC"/>
    <dbReference type="OrthoDB" id="414546at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009646">
        <property type="term" value="P:response to absence of light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090549">
        <property type="term" value="P:response to carbon starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000008">
        <property type="entry name" value="Programmed cell death protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000009">
        <property type="entry name" value="programmed cell death protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF2">
        <property type="entry name" value="MA3 DOMAIN-CONTAINING TRANSLATION REGULATORY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="124"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="288"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="423"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="591"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="719" mass="79907" checksum="953C5DDFA4F82E1C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX93</accession>
    <name>A0A103XX93_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_023235</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003791">
        <property type="protein sequence ID" value="KVH98549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX93"/>
    <dbReference type="STRING" id="59895.A0A103XX93"/>
    <dbReference type="Gramene" id="KVH98549">
        <property type="protein sequence ID" value="KVH98549"/>
        <property type="gene ID" value="Ccrd_023235"/>
    </dbReference>
    <dbReference type="OMA" id="FTPCVAP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH98549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="456" mass="52374" checksum="CBF85174A67D5859" modified="2016-04-13" version="1" fragment="single">MQKKRWRKLGLMRRVLTCAIALISFVALFSAHLHLFFPPSQVSMLPDPYKLPTQHEIRYQKLSRERSWIRPHLSKAPLPALKLDGANGSSDFNKLWKRPPNRDFAPCVDPSLSYIAPLETRGYLLVHTNGGLNQMRAGICDMVAVARIINATLVVPELDKRSFWQDTSNFSDVFDEDYFIKSLVNDVKIIKKLPRELMTATRAVKHFRSWSGIDYYEQEIVSLWDDYQVIRAAKSDSRLANNNLPPDIQKLRCRACYKALRFSPRIEAMGKLLVDRMRSYGPYIALHLRYEKDMLAFKQRAKGYCPLTPKEVGFFLRALGFPPTTPIYIAAGEIYGGDSRMAALQSRFPTLMKKITLCRWRATFSFPLILGTWQGQKLLVRIFDKIANGTMKEGKKLSGRIIEIHKRRQGSPRKRKGPISGTKGTDRFRSEEAFYVNPLPDCLCQKESTENENSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXE1</accession>
    <name>A0A103XXE1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003786">
        <property type="protein sequence ID" value="KVH98595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXE1"/>
    <dbReference type="STRING" id="59895.A0A103XXE1"/>
    <dbReference type="Gramene" id="KVH98595">
        <property type="protein sequence ID" value="KVH98595"/>
        <property type="gene ID" value="Ccrd_023180"/>
    </dbReference>
    <dbReference type="OMA" id="YFGWEYN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000012">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000010">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="420" mass="47917" checksum="0787A9C7F388F23E" modified="2016-04-13" version="1" fragment="single">MDDNQSELIMELRSKLSSFEQKVKELESENARLASLVLSCSCHKVEENFNTNFTDSNTFSDKLEKLKLGNCVGNGKRKPRKRLSGYNLNSMNHHSQRFVALKIMYFGQRFYGFASEAQMDPTIESELFKALEKTRLVLSDKKDLQYSRCGRTDKGVSSVGQVVSLLLRSKRKEHGGNTYEELVDKEGELDYVRILNGVLPDDIRVIGWSPAPVNFSARFSCLSREYIYFFWREHLNILAMQSSCKRLIGEHDFRNFCKMDAANVHNYKRRITSFDICPCNGSDELMLLKVKGSAFLWHQVRCMVAVLFLIGQGLESPDVIDALLDVEKTPRKPQYKMAPEIPLVLQSCEFEGLKFICSSDARRALQLHLEKESQTYKLQAAIFHEALTSLSSTEDDAGATSNKIKKKFSSHVPLMSRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXR9</accession>
    <name>A0A103XXR9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003663">
        <property type="protein sequence ID" value="KVH98822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXR9"/>
    <dbReference type="STRING" id="59895.A0A103XXR9"/>
    <dbReference type="Gramene" id="KVH98822">
        <property type="protein sequence ID" value="KVH98822"/>
        <property type="gene ID" value="Ccrd_022949"/>
    </dbReference>
    <dbReference type="OMA" id="GCWEEIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF21">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 27-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="32758" checksum="1F3BDA4FFBD7D864" modified="2016-04-13" version="1">MTLKGGTSQACAACKYQRKRCTPECALAPHFRPEHTEIFKNAHKLFGVRKILRILEKIDPSQKTEAMRSIIYQANMRDRFPVHGCLGEIYHLQYQIRQAEKELYAVLSHLHFYKQQSPQQEITIDSSPESQLGMGLQQSAANGLTLFQHQQQFLPVAPFFDQSYNNNNHSGIHFDSMSNTGNDGMWLQQTYCNQNDGKTLVALQSQLLNTQPWTIQEEVTHDYDEIYPFFDTIDDTQSYIDSKDANESSSESSLKETTQSVQHVAGNKLKRAELQLGIVSEDYQATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY37</accession>
    <name>A0A103XY37_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH99002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY37"/>
    <dbReference type="STRING" id="59895.A0A103XY37"/>
    <dbReference type="Gramene" id="KVH99002">
        <property type="protein sequence ID" value="KVH99002"/>
        <property type="gene ID" value="Ccrd_022779"/>
    </dbReference>
    <dbReference type="OMA" id="THESRNC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="376" mass="42922" checksum="E81985C571242DC7" modified="2016-04-13" version="1" fragment="single">MTPASHPSNLQANSVSDAIFIWKSARHASLGDADPSYKYVIFPLLGIDKFIHCYTHESRNCLGECEKSGCVGKRCFPHCTFSSDGASLDFPWYTQEPSYMRWKQWDCQSDCRYYCMLNSDRVRSSFGHGIVKYHSKWPFKRVFGIQQPASVAFSALNLAMHFHGWLSFFILLYYKLPTGLDKKPYYDYAGLFHLYGLLALNSWFWGTVFHSRDVEFTGKLHYFSGIVLVGYSLILAILRCFNVKLEAARVMVSAPLLAFVTVHILYLNNYQMDYGMNMKVCVVMAAAQLLIWAIWAGTSCHPSRQKLWLVVVAGAAVMLLEIYDFPSYEGFLDAHTASHAITIPLTYTWWSFIKDDVEFTTSTLLKNGKMASRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ30</accession>
    <name>A0A103XZ30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003512">
        <property type="protein sequence ID" value="KVH99466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ30"/>
    <dbReference type="STRING" id="59895.A0A103XZ30"/>
    <dbReference type="Gramene" id="KVH99466">
        <property type="protein sequence ID" value="KVH99466"/>
        <property type="gene ID" value="Ccrd_022300"/>
    </dbReference>
    <dbReference type="OMA" id="STHRGWN"/>
    <dbReference type="OrthoDB" id="667051at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012442">
        <property type="entry name" value="DUF1645_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095:SF14">
        <property type="entry name" value="AR781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095">
        <property type="entry name" value="OS07G0619500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07816">
        <property type="entry name" value="DUF1645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="34162" checksum="0506A8C9E00D0A46" modified="2016-04-13" version="1">MEVVAKPMDFHFNSPANSSAPSTPKRMGDHYFSAPTSPTRLFEFDQLLRLISADHHQNPSPATVPFAWEEKPGVPNSLYKFLEHDFAFDVSGDQLGMDSVIPAEDLFDGGVIRVLPENTKERKNTSMEEKRKRTSSFSSSAGLPSSRSRRTQSFSHKRGWECPWEEEEEESQAAMNAKPQLVSSCSSLSASKGSRKWSFKDLFLFRSASDGRAMDRDPLKKYSAIIRKHDEDFRNSSLRSVGSGSGSKRRGGVSAHELHYKVNRAVANDLKKKTFLPYKQGILGRLAFNPTVHALSNGFGFSHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZP2</accession>
    <name>A0A103XZP2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZP2"/>
    <dbReference type="Gramene" id="KVH99833">
        <property type="protein sequence ID" value="KVH99833"/>
        <property type="gene ID" value="Ccrd_021969"/>
    </dbReference>
    <dbReference type="OMA" id="GKWVESY"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000242">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000427">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF501">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="500"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="592" mass="66874" checksum="7C021421E80B647E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0B3</accession>
    <name>A0A103Y0B3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003397">
        <property type="protein sequence ID" value="KVI00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0B3"/>
    <dbReference type="STRING" id="59895.A0A103Y0B3"/>
    <dbReference type="Gramene" id="KVI00192">
        <property type="protein sequence ID" value="KVI00192"/>
        <property type="gene ID" value="Ccrd_021565"/>
    </dbReference>
    <dbReference type="OMA" id="ARCKSEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF43">
        <property type="entry name" value="STORAGE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="539" mass="61105" checksum="B2F6A82033FD0DFC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0F1</accession>
    <name>A0A103Y0F1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0F1"/>
    <dbReference type="STRING" id="59895.A0A103Y0F1"/>
    <dbReference type="Gramene" id="KVI00234">
        <property type="protein sequence ID" value="KVI00234"/>
        <property type="gene ID" value="Ccrd_021484"/>
    </dbReference>
    <dbReference type="OMA" id="KEYIHME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012438">
        <property type="entry name" value="DUF1639"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33130:SF12">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33130">
        <property type="entry name" value="PUTATIVE (DUF1639)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07797">
        <property type="entry name" value="DUF1639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="23362" checksum="63146F84BB140040" modified="2016-04-13" version="1">MDKLQWGNRKRLRCVKVKESTVMNGKSDGNGIVVKKKITSQRVDRRVVNEQDSHHPLPPLHASSPQRLNRVTNRKIMSALSSPEKEDRYYSTRGSGAGFDDSSSSKKVLNVDAKKESKRAVWPKLFTTLSSKEKEEDFMAMKGCKLPQRPKKRAKMIQRTLLLVSPGAWLSDLCQERYEVREKKTSKKVRPRGLKAMGSMESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1X9</accession>
    <name>A0A103Y1X9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003140">
        <property type="protein sequence ID" value="KVI01017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1X9"/>
    <dbReference type="Gramene" id="KVI01017">
        <property type="protein sequence ID" value="KVI01017"/>
        <property type="gene ID" value="Ccrd_020716"/>
    </dbReference>
    <dbReference type="OMA" id="PTRITEC"/>
    <dbReference type="OrthoDB" id="2274046at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF8">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="1">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="17169" checksum="7AC35E9486176153" modified="2016-04-13" version="1">MAETATVEINKQQSEQVGTGVVKRKPVFLKVGELKPGTTGNTLAVKVLSSTTVLDKKSRNTSSFSGRSGAAHTHIAECLIGDETGTIVFTARNDQVDLMKPGTTVIIRNAKIDMFKGSMRLAVDKWGRIEVTEPATFTVKEDNNLSLVEYELVNVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y348</accession>
    <name>A0A103Y348_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized GPI-anchored protein At5g19230-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002947">
        <property type="protein sequence ID" value="KVI01630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y348"/>
    <dbReference type="STRING" id="59895.A0A103Y348"/>
    <dbReference type="Gramene" id="KVI01630">
        <property type="protein sequence ID" value="KVI01630"/>
        <property type="gene ID" value="Ccrd_020094"/>
    </dbReference>
    <dbReference type="OMA" id="ASEDNWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045285">
        <property type="entry name" value="At5g19230-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059083">
        <property type="entry name" value="At5g19230_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33976">
        <property type="entry name" value="OS07G0645000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33976:SF8">
        <property type="entry name" value="OS07G0645000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25884">
        <property type="entry name" value="At5g19230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uncharacterized GPI-anchored protein At5g19230-like" evidence="1">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="222" mass="24484" checksum="684C689DFAD0FA70" modified="2016-04-13" version="1" fragment="single">TPFHQALPLYITQLCCIYLSSLPFDSFTDQAKMAMEYCQRFVILTLLLHSIFCINHLVKCDGINSYRATVNLTTLTQNDRAKCLADKIADQLKDRPCTNTTGSNTVPGTEPEFANYPDLLDKCHLNVSTTRDGGVLPACVPNLDPGLVISNYTRSQYSSYLNDTKYTGIGIGSEDDWIVVVLTTSTPEGGYSPGSNDVNFVSKIGPVHYSMVLLVVVLLLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y399</accession>
    <name>A0A103Y399_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="5">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01002689">
        <property type="protein sequence ID" value="KVI01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y399"/>
    <dbReference type="STRING" id="59895.A0A103Y399"/>
    <dbReference type="Gramene" id="KVI01745">
        <property type="protein sequence ID" value="KVI01745"/>
        <property type="gene ID" value="Ccrd_019976"/>
    </dbReference>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="331"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="585" mass="63418" checksum="3C852C3C57590A8C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3Q6</accession>
    <name>A0A103Y3Q6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3Q6"/>
    <dbReference type="STRING" id="59895.A0A103Y3Q6"/>
    <dbReference type="Gramene" id="KVI01962">
        <property type="protein sequence ID" value="KVI01962"/>
        <property type="gene ID" value="Ccrd_019745"/>
    </dbReference>
    <dbReference type="OMA" id="DVVECHC"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="85"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="53278" checksum="B445B03E068490FE" modified="2016-04-13" version="1" fragment="single">MEVEDCMSSGGEDYYCSDRDSLDDALENEDSDSQWAPPKGSSSKFTLWVVTGEMYGDRSSVITKESLLAAQREDLRRVMELLSLREHHARTLLIHYRWDVEKIFAVLVEKGKIRLFTEAGWTEHFVVKINEGQSRRIRCMAHKCFAICDEAIIRNLVSKRHPDLAEKFDRFLLESYIEDNKMVKWCPSTPHCGNAIRVEEDEFCEVECSCGNQFCFSCLCEAHSPCSCAMWALWTKKCRDESETVNWITVHTKPCPNWLCGGATGRDHTWSNITGHSCGRYKEDREKKSERAKRDLYRYMHYHNRYKAHTDSFKQESRLKETIRDKVAVLESKDSQLRDFSWVTNGLYRLFRSRRSLSYSYPFAFYMFGDELFNDEMTKEDLEIKQHLFEDQQQQLETNVEKLSKFIEEPFDQYPDDRIMDIRMQTDLLGSLQFGIHNIAPYYSKGIEKATELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4H0</accession>
    <name>A0A103Y4H0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4H0"/>
    <dbReference type="Gramene" id="KVI02347">
        <property type="protein sequence ID" value="KVI02347"/>
        <property type="gene ID" value="Ccrd_019323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00180">
        <property type="entry name" value="Shadow ORF (opposite PGK1)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="416" mass="46186" checksum="962417F0EAD6160C" modified="2016-04-13" version="1">MRPLNHPRWQQMASLGLKLPHQDNPIPKAKTNRTSHSQEEEHRPLEVKPLTFQPPDQHSHQPSQPLIRWLSLNITSPKRKTEKNHDLVTQCVSPALSFKKINSPDTVDDNRGCSTYGNTIKIVIEEEKATYQVTGKDNFSTIADEVLDCRNGCSDSCIVCDILTVVQRHIQISPNEHLLSLEFSRREVSNALLSHRDNACNWFSRGFDGSELGAYMCRQKGISGGKAEGRKRRAQKTRRETKDRVVAAGETATTASSRASTPGSVLPSNNSKLAPPPVEIWLITSATPTFSTAATESPPPMIVVTPFPLSSANFFAIACKHTYIQLYHLYYTSVYQRKPFLSSQPHPMCLRIFVVSNASLNVLIESGPISNPIQPSGIADAGTICIVKEGVQTCLRPPHRLATRGILPSLWPWRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4H6</accession>
    <name>A0A103Y4H6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002655">
        <property type="protein sequence ID" value="KVI02334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI02334">
        <property type="protein sequence ID" value="KVI02334"/>
        <property type="gene ID" value="Ccrd_019377"/>
    </dbReference>
    <dbReference type="OMA" id="ENDMLTW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1384" mass="153101" checksum="05E2E81009326B75" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y649</accession>
    <name>A0A103Y649_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LURP1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002403">
        <property type="protein sequence ID" value="KVI03231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y649"/>
    <dbReference type="STRING" id="59895.A0A103Y649"/>
    <dbReference type="Gramene" id="KVI03231">
        <property type="protein sequence ID" value="KVI03231"/>
        <property type="gene ID" value="Ccrd_018473"/>
    </dbReference>
    <dbReference type="OMA" id="LADEWSI"/>
    <dbReference type="OrthoDB" id="748129at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF138">
        <property type="entry name" value="TUBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="197" mass="22350" checksum="11F535F6D08CB917" modified="2016-04-13" version="1">MTKVHPNAVVSHNHRQPLSHGHTLLPLIVWKKSLLFNCYGFTVFDSNGNLVFRVDNYSSGIKDQILLMDASGHSLLTIRRKRLSLLDNWLVYEGETAVNPRFTVTKRVNLINTKSLAHVTATGSRTKRPMYEIEGSYTQRSCVVYDDKRRRVAEIKRKEAVGGVAFGGDVFRLFLHDSQMDPAVAMAMVIILDQMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAE1</accession>
    <name>A0A103YAE1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAE1"/>
    <dbReference type="STRING" id="59895.A0A103YAE1"/>
    <dbReference type="Gramene" id="KVI05464">
        <property type="protein sequence ID" value="KVI05464"/>
        <property type="gene ID" value="Ccrd_016243"/>
    </dbReference>
    <dbReference type="OMA" id="ISLFCNE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36712">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36712:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20615" checksum="64420B0B0E23FCBF" modified="2016-04-13" version="1">MRIVDQNNGGGGLRKVIVGIKVTGNFETFPFFDQSSEMSRLYDGWNEILKIQKFRRTVGYTIFFSFSALISYAYNSNTTRAGYSRGDQFYASYPAGSELLTDTTKVSGISLFCNELFVVGVQERTELSLYKSALGNCFEEEEWGPIEWSVMSKHFERQGKSPYAYHAQYQAHLASNGHLDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAM9</accession>
    <name>A0A103YAM9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAM9"/>
    <dbReference type="STRING" id="59895.A0A103YAM9"/>
    <dbReference type="Gramene" id="KVI05603">
        <property type="protein sequence ID" value="KVI05603"/>
        <property type="gene ID" value="Ccrd_016041"/>
    </dbReference>
    <dbReference type="OMA" id="CAYQYDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13833">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13833:SF57">
        <property type="entry name" value="NHL REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119540" evidence="3">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="488" mass="54350" checksum="E1F64D46F1687D69" modified="2016-04-13" version="1">MAKIVFLFSLALLLLLGTTSAAQPTSPTRIVNGLFSNVASSLMKWAWSLKTTTKPAITGRPMMKFESGYNVETVFDGSKLGIEPHALEVLPNGELLVLDSANSNLYKISSSLSLYSRPKLVAGSADGYSGHVDGRLREAKMNHPKGLTVDDKGNIYIADTANMAIRKISDTGVTTIAGGSKLGRGGGHVDGPSEDAKFSNDFDVLYIGSSCSLLVIDRGNQAIREIQLPFDDWIAVLVAAGFFGYMLALLQRRDEPQTTMKQSIAPTPPYQKLPVRPPLIPSETEPEKQEEGFFGSLGKLMANATSSFSEILGGVFPGFRKKQLNYHFQNQQSFHQDHKYASSSWPVQDSYVIPEGDEPPPSIETRTPTPKKTYPFMTSDAEKMQQFRQSRHLYSGWDRDVQQPPQLQQQQQQQQHQQQQQHQHHNRYYSSMAETYYEQSAEKTKEIVFGAVQEQAESMVIKPLDHGNPVYDHRGKIRSRSRGFARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAT0</accession>
    <name>A0A103YAT0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001863">
        <property type="protein sequence ID" value="KVI05678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAT0"/>
    <dbReference type="STRING" id="59895.A0A103YAT0"/>
    <dbReference type="Gramene" id="KVI05678">
        <property type="protein sequence ID" value="KVI05678"/>
        <property type="gene ID" value="Ccrd_015989"/>
    </dbReference>
    <dbReference type="OMA" id="THRDMNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040300">
        <property type="entry name" value="At3g49055-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34937">
        <property type="entry name" value="OS08G0559800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34937:SF1">
        <property type="entry name" value="PARAMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="643" mass="72626" checksum="FEAFEC434F7BC93A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAY7</accession>
    <name>A0A103YAY7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">At2g35280-like TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAY7"/>
    <dbReference type="STRING" id="59895.A0A103YAY7"/>
    <dbReference type="Gramene" id="KVI05759">
        <property type="protein sequence ID" value="KVI05759"/>
        <property type="gene ID" value="Ccrd_015936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040338">
        <property type="entry name" value="At1g67623-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057136">
        <property type="entry name" value="At2g35280_TPR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784:SF49">
        <property type="entry name" value="F-BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784">
        <property type="entry name" value="OS05G0482100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23310">
        <property type="entry name" value="TPR_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g35280-like TPR" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17572" checksum="1E2961C489E71E66" modified="2016-04-13" version="1">MSSRDTNCRSSSIGRRRRKINAVRMNGKSKSAVGKQRRPVVGSLPGDLLIDVLARVASSSFTDLFNAKLSCRDFLGAAEDEYIFQHVSIDKFPVIHWFPPSDELLSFLNQCIDKGNPEAMFRQGMFGTDRNGTRVLEKGVGKRPCRGNICIRYDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBR1</accession>
    <name>A0A103YBR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_015444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001845">
        <property type="protein sequence ID" value="KVI06173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBR1"/>
    <dbReference type="STRING" id="59895.A0A103YBR1"/>
    <dbReference type="Gramene" id="KVI06173">
        <property type="protein sequence ID" value="KVI06173"/>
        <property type="gene ID" value="Ccrd_015444"/>
    </dbReference>
    <dbReference type="OMA" id="HDFKGLM"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000172">
        <property type="entry name" value="cyclin-dependent kinase G-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF578">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE F-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="319"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI06173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="623" mass="70518" checksum="D724F9DB9A036D3B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCC8</accession>
    <name>A0A103YCC8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_015168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the early nodulin-like (ENODL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCC8"/>
    <dbReference type="STRING" id="59895.A0A103YCC8"/>
    <dbReference type="Gramene" id="KVI06477">
        <property type="protein sequence ID" value="KVI06477"/>
        <property type="gene ID" value="Ccrd_015168"/>
    </dbReference>
    <dbReference type="OMA" id="SGETGHC"/>
    <dbReference type="OrthoDB" id="959565at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11019">
        <property type="entry name" value="OsENODL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000010">
        <property type="entry name" value="Early nodulin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041846">
        <property type="entry name" value="ENL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF289">
        <property type="entry name" value="EARLY NODULIN-LIKE PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119584" description="Phytocyanin domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI06477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="19388" checksum="92B1352970378230" modified="2016-04-13" version="1">MTQITILFISFALFSILKVQPIDFQVGGDKGWSIPPSNDTRLFDQWASKNRFNINDTLRFEYKKDSVLVVSKEEHEKCKSVHPVFFSNNGDTSFELDRSGFFYFISGVSGHCERGLKMIVKVLEPENVAAQSANQTASMKNGGMGLVKMSGDMYSQISVVIMGSVSLFMMLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCK3</accession>
    <name>A0A103YCK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001781">
        <property type="protein sequence ID" value="KVI06622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCK3"/>
    <dbReference type="STRING" id="59895.A0A103YCK3"/>
    <dbReference type="Gramene" id="KVI06622">
        <property type="protein sequence ID" value="KVI06622"/>
        <property type="gene ID" value="Ccrd_015026"/>
    </dbReference>
    <dbReference type="OMA" id="PKNPLPC"/>
    <dbReference type="OrthoDB" id="2018237at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF11">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="195" mass="21462" checksum="222E3DCABE1D57CA" modified="2016-04-13" version="1">MGGGVPPKQPLFCLKWPWDVHSNANPTDSCSSGPPWLFKSFQTVASLALTVVDSISKPQIRTPLQFSSKTTRTKDLGVEEQGELEQKALACALANGKDATVIEFYSPKCSLCNSMVDFVGHVENNNADWLNIVMADAENDKWLPELLHYDIKYVPCFVLLDKHGRALAKTGVPSSRLHVVAGVSHLLKIKRSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEP5</accession>
    <name>A0A103YEP5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001493">
        <property type="protein sequence ID" value="KVI07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEP5"/>
    <dbReference type="STRING" id="59895.A0A103YEP5"/>
    <dbReference type="Gramene" id="KVI07720">
        <property type="protein sequence ID" value="KVI07720"/>
        <property type="gene ID" value="Ccrd_013898"/>
    </dbReference>
    <dbReference type="OMA" id="FKHTDQE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033542">
        <property type="term" value="P:fatty acid beta-oxidation, unsaturated, even number"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="30083" checksum="B863D36104C6D30E" modified="2016-04-13" version="1">MGDDAAMNPELIINHKFPETTYTYSERDAALYALGIGACAKDALDDKDLKYVYHEDGQQSIQVFPTFAALFSIGLTSQLKHLPGFMFDPRLLLHGQQYIEIYKPLPSNCKATILEVEVLSYEKETGEPLCMNRTTVYLRGAGGFSKSSEPYSFSKYPRDQTSSKPPRTRPFVVHEECTQPSQALLYRLSGDYNPLHSDPMVAEVAGAIIKTICNGDASLVKAISGRFLLHVYPGETLITEIVLYQTKVKERNRVVLAGFVDLNSIRSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG07</accession>
    <name>A0A103YG07_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYB-CC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001126">
        <property type="protein sequence ID" value="KVI08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG07"/>
    <dbReference type="STRING" id="59895.A0A103YG07"/>
    <dbReference type="Gramene" id="KVI08393">
        <property type="protein sequence ID" value="KVI08393"/>
        <property type="gene ID" value="Ccrd_013235"/>
    </dbReference>
    <dbReference type="OMA" id="SCEGSKK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025756">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046955">
        <property type="entry name" value="PHR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR PHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499:SF2">
        <property type="entry name" value="MYB-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14379">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="41146" checksum="9007C01CEBC1B642" modified="2016-04-13" version="1">MSITPERHMFLQGGSGRGNSGLVLSTDAKPRLKWTPDLHERFIEAVNQLGGADKATPKSVLKLMGIQGLTLYHLKSHLQKYRLGKNLCGQPNGGGANKISKTLEPLISDVIQRMVPQARDRMVGTDDIHMSNSSVGPQTNKYEVQRHLQLRIEAQGKYLQAVLEKAQETVGRQNLGAVGLETAKVQLSELVSKVSTHRLNSAFSGMKDVSNRSNQPTDCSIDSCLTYGEGQQMDQEMMGLNFLNGSSNAPLKSKKVEDEPENIWCEEMKRNKKFLSSSDLSMSVGLESSEWNTDRSYSEQRFTCRDEDAIFMDQVTRNKTEPIKPENMDITQKFQLPYFEKKLDLNAHDENDAASSRKQFDLNGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI48</accession>
    <name>A0A103YI48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001057">
        <property type="protein sequence ID" value="KVI09519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI48"/>
    <dbReference type="STRING" id="59895.A0A103YI48"/>
    <dbReference type="Gramene" id="KVI09519">
        <property type="protein sequence ID" value="KVI09519"/>
        <property type="gene ID" value="Ccrd_012086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="55566" checksum="2DCB8305E2AE9E4B" modified="2016-04-13" version="1">MSQLLKRVREWVFNGWITSGSTSDQTIVCSSSTGEVHRLPLDIFMQILKLLGPKDAARLAAVCKSWKLMVYDNTLWLYFLKNQEDGVSIFFAETKLRYFPLRQYHRRMLSFMHIYGERAQATGAIIIDVGAGYCKIGSSKYDSPSLRLRTWEFGNPRSPLTARVHHFCETVYRRMHVKPSMQPVILTTPIGFYPGPGTEAASSQQLRDAVFSALIRIRVPSETLALFASRRTSGILVNIGYHKTQVFPILHGYTRHEVVSVRVGGSDLTRYLWRQLLQRNVYVPSLKSVSSLKENLCYVALDYEAELQKDTEASYQVGSEGWYTLKQERFQTGEVLFLPHIAGRRFMGLHQAVGHCIECQAKRSTGDHNWYKTIVLAGGTARLPGLAERLDKELHDLLPPNISHGIRVIQSPYGADAAWHGAKMFGNVRSCLLFLFGLTGSLWNQLELLSNLMVLVMIFWRVVSIDSTSKIPRKFMASKFLFWILESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJT7</accession>
    <name>A0A103YJT7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011198</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJT7"/>
    <dbReference type="STRING" id="59895.A0A103YJT7"/>
    <dbReference type="Gramene" id="KVI10392">
        <property type="protein sequence ID" value="KVI10392"/>
        <property type="gene ID" value="Ccrd_011198"/>
    </dbReference>
    <dbReference type="OMA" id="MFNNYGD"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000001">
        <property type="entry name" value="Aspartate carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF6">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="12">
        <location>
            <begin position="85"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="11">
        <location>
            <begin position="233"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="42254" checksum="43172652F4CF317A" modified="2016-04-13" version="1">MPSSMFSMRASHGTTLAPEQSTIFRDSMYNKPNFFYKHLLCFKRSCVSSNLAHSSVSQKDIIQCRAVEVASNRTFLKGEKFQLHDVIEAQQFDRDILSAIFEVAREMEIIEKKSRGSQLLNGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYTDIIVMRHFESGAARRAAMTANIPIINAGDGPGEHPTQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLAYLLAKYNDVKVYFVSPEEDIKEYLTSKGVEWEESADLKEVASKCDVVYQTRIQKERFGERTDLYEEACGKYIVDREILDVMQKHAVITVDVDGDPRAAYFRQAKNGLYIRMALLKLLLLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKE0</accession>
    <name>A0A103YKE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001001">
        <property type="protein sequence ID" value="KVI10774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKE0"/>
    <dbReference type="STRING" id="59895.A0A103YKE0"/>
    <dbReference type="Gramene" id="KVI10774">
        <property type="protein sequence ID" value="KVI10774"/>
        <property type="gene ID" value="Ccrd_010824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="105" mass="12554" checksum="35DE48146F7B3009" modified="2016-04-13" version="1">MGLQHVSWCALLETIQVIEIIGTPKKWLFMVVDQGLTKELSKYHWVKSLITKRDIVYESLTYSSELYVSARLIWKNDRCRSKNKQFDRKDLSNDFSRSFYSKWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLW1</accession>
    <name>A0A103YLW1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ERBB-3 BINDING PROTEIN 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_010163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Required for expression of cell cycle genes such as CYCD3-1, RNR2A and CDKB1-1. Promotes, in a dose- and auxin-dependent manner, organ growth by stimulating both cell proliferation and expansion, via the regulation of RBR1 levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000128">
        <property type="protein sequence ID" value="KVI11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLW1"/>
    <dbReference type="STRING" id="59895.A0A103YLW1"/>
    <dbReference type="Gramene" id="KVI11425">
        <property type="protein sequence ID" value="KVI11425"/>
        <property type="gene ID" value="Ccrd_010163"/>
    </dbReference>
    <dbReference type="OMA" id="GMGPYIG"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000012">
        <property type="entry name" value="ERBB-3 BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="388" mass="42971" checksum="7CC4A5F5E063CEA1" modified="2016-04-13" version="1">MSDDERGEEKELDITSSEVVTKYKLAAEIVNKALQLVLSECKPKAKIVDICEKGDSYIREQTGSMYKNVKKKIERGVAFPTCLSVNNTVCHYSPLASDEAVLEEGDILKIDMGCHIDGFIAVVGHTHVLQQGPVTGRAADAIAAANTAAEVALRLVKPGKKNQDVTEAIQKVAAAYDCKIVEGVLSHQLKQFVIDGNKVVLSVSNPETRVDDAEFEENEVYAIDIVTSTGDGKPKLLDEKQTTIYKRAVDKNYHLKMKASRFIFSEINQKYPIMPFSARALEEKRARLGLVECVNHELLQPYPVLHEKPGDFVAHIKFTVLLMPNGSDRITSHTLQELQPTKIVDDPEIKAWLSLPVKAKKKSGGKKKKGRTVEKVEEAMEESSNGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNJ2</accession>
    <name>A0A103YNJ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000005">
        <property type="protein sequence ID" value="KVI12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNJ2"/>
    <dbReference type="Gramene" id="KVI12369">
        <property type="protein sequence ID" value="KVI12369"/>
        <property type="gene ID" value="Ccrd_009216"/>
    </dbReference>
    <dbReference type="OMA" id="PMEIAIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="493" mass="57402" checksum="3275A6D8C0B68ECB" modified="2016-04-13" version="1">MKNNGKNPIDSSIHVNSDEDRVYVNSHEENVDVMKVVTWEASEEFDVGLSPFTDVQRNCEEIGLVDDIETHVIDDSTGYTSNNEIQNDESPVVEEVIKPVIGYVYPSLDVAESIYQKYAESAGFEVRRSTQKINPDGVIQNKYFVCSRFGLPLKKSFDSMVRRKHQRELRNSNIKRIGCTTSVKFRLMKGTTTYECYGFEEDHNHSLLRHDDMDLTRKGRQMKFSDQRFFSYDLLNNTTFKKQNFKLVWNIHISPDEFESRWMVQTEIHRAAWTCSIKSVNSNEEAETYLIEHLDKRDEKIAEYKVVRNLKESTVVCSCNHHRHVFKVLLNAGVETIPEEYILRRWRSDLIPIELQNSRQRICDVGEDQRRIINDTYEIVDDVLDILRNDKEKLESFVVKLREMRDDVAKDRTYEPSMKRKERGIEQILGFTRPDNIEIHPATGIRNKGCGTSKRLIGAAEKAAVNSSRPKRMCRGCNMLSNHDIRNCPNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118H795</accession>
    <name>A0A118H795_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heavy metal-associated domain, HMA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008284">
        <property type="protein sequence ID" value="KVG33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118H795"/>
    <dbReference type="STRING" id="59895.A0A118H795"/>
    <dbReference type="Gramene" id="KVG33796">
        <property type="protein sequence ID" value="KVG33796"/>
        <property type="gene ID" value="Ccrd_026488"/>
    </dbReference>
    <dbReference type="OMA" id="YVTRCDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47005">
        <property type="entry name" value="HEAVY METAL TRANSPORT/DETOXIFICATION SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47005:SF5">
        <property type="entry name" value="HEAVY METAL TRANSPORT_DETOXIFICATION SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34004" checksum="C8C820354D86A73D" modified="2016-04-13" version="1">MAPDKVTVMILNVDLKCSCCYKKVKKLLCKFPRQFPSLSLSLLFPFGFLSKSIIHDHSFFHLPPAFLAEIRDQVFDQDKNEVRITVVCCNPDKLRDTLCCKGGKAIQSIEIVEDKPNPKPKPQDKPKPDPNPSPVQKPKPADPPPPPPKVDPPKPADPAPPAPPKVDPPKPADPPPPPPKPKVDPPKPADPPPPPPKVDPPPPKVDPPKPADPPPPPKVDPPKPVPIPDPMPGFCPPVYPVPIQACCQECYQGRSGGPCYDFGYNYGRPVPPPPGPCYDGYGYEYARNRPCYVTRCDYFSEENPQGCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JBZ6</accession>
    <name>A0A118JBZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006633">
        <property type="protein sequence ID" value="KVH64302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JBZ6"/>
    <dbReference type="Gramene" id="KVH64302">
        <property type="protein sequence ID" value="KVH64302"/>
        <property type="gene ID" value="Ccrd_025642"/>
    </dbReference>
    <dbReference type="OMA" id="WRITIEA"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051357">
        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF46">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC SUVH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="5">
        <location>
            <begin position="253"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH64302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="47045" checksum="A550441558635A39" modified="2016-04-13" version="1">MKKISQPVIPRKXLLDDDDDCVLEEIIKPRKVVSKYPPPKIRTGVQVVRDFPPGCGIIDNSLRNXAERILLKHFDKYGSKIRKMTXNDKDKLADSRCFENNELKTSKPKESGGNTPLGSRPTGKVQFWDPNLSKEGNDQKPEDIANGGSRKEQFRLEKSRRPAGKVKFWDPRTEEGDAQKPEDTTTVVSRKEQFRREKINEAMAMFEDVYERLYLENRSKPKXEKIAHWRITIEAAKIVKQRKKLMDVDKVLGHICGIRVGDKFKFRAQLHMVGLHCQLQSGIDYAKVRGKNLAISIVDSQRYLNERESCDALLYSGHGGVKFLGGRPEDQKLERGNLALKNSINEKNPVRVIRKLHTGSGKNNDVFVYDGLYIVKGYKQQKGAEGKMVFMFQLKRIPAQPQLHKMLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JH32</accession>
    <name>A0A118JH32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phloem protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006548">
        <property type="protein sequence ID" value="KVH72232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JH32"/>
    <dbReference type="STRING" id="59895.A0A118JH32"/>
    <dbReference type="Gramene" id="KVH72232">
        <property type="protein sequence ID" value="KVH72232"/>
        <property type="gene ID" value="Ccrd_025590"/>
    </dbReference>
    <dbReference type="OMA" id="ACERNHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278:SF135">
        <property type="entry name" value="F-BOX PROTEIN PP2-B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH72232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="338" mass="39721" checksum="761193731AB7B7D2" modified="2016-04-13" version="1" fragment="single">RFPEFNLVALGGEFKAHVKPKFLSPGITYTVNLVFKLINRNGNSNGPMYLVLDYKLKGETKYSTAYLAHEREDRWMTVELYQFTSHERDFDLEILFDGTQIHLDALVVEGIEFRPSERVASEVEEVDIQPISDLDTDWERKLPEDHEEIIKWFGDSIEWTTKKELYFLFCKGFVINDDKERFFLAKNGKKCLFLTARAHLNRRERRFESILNLRFGEVALYRFGSYIHIHGEIDFQILSPGTTYACNLVYKITRDVDKIEEPVEVRNWNLPFPDSDGIYYRYIYLLSPQLPVIRPNVDENSHNPSISQMPKIKGLPRLRNDGWMEVEIWEFETSVGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS47</accession>
    <name>A0A118JS47_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6821 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005939">
        <property type="protein sequence ID" value="KVH87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS47"/>
    <dbReference type="STRING" id="59895.A0A118JS47"/>
    <dbReference type="Gramene" id="KVH87671">
        <property type="protein sequence ID" value="KVH87671"/>
        <property type="gene ID" value="Ccrd_025043"/>
    </dbReference>
    <dbReference type="OMA" id="KRVVWWK"/>
    <dbReference type="OrthoDB" id="1931521at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045883">
        <property type="entry name" value="At4g13530-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049224">
        <property type="entry name" value="DUF6821"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33646">
        <property type="entry name" value="GB|AAF00631.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33646:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20705">
        <property type="entry name" value="DUF6821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6821" evidence="2">
        <location>
            <begin position="140"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="300" mass="33994" checksum="9E0EE950C84ADD37" modified="2016-04-13" version="1">MDVELNDWEVLPNSEDSTSLQNTSYLEGIERDSEGIIRSDYFSLDSRNKYAGTQVEDVTDGISVESDNPSWIDPACDTRYSTTKEMGEFWSTDGSSDDGKYVESEANNKELDIGETGTRQVAYDGSASVEMDKSWSDSGEIESKTRNYEKMDVDTYDDDMKIHEPSGEQKIIQARDQGENEDVLIETRKADSEERNRVAVWWKLPFDLLKYCLYRASPVWTLSVAAAMMGVVILGRRLYKMKRKSRTLQLKVTVDDKKVSQFMSRAARLNEAFSVVKRGPIIRPSLPAAGIAPWPMMALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSR3</accession>
    <name>A0A118JSR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005312">
        <property type="protein sequence ID" value="KVH89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSR3"/>
    <dbReference type="STRING" id="59895.A0A118JSR3"/>
    <dbReference type="Gramene" id="KVH89096">
        <property type="protein sequence ID" value="KVH89096"/>
        <property type="gene ID" value="Ccrd_008924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="105" mass="11613" checksum="884D4821829AD5E4" modified="2016-04-13" version="1">MEIPCGQKLIQTQRASTGKSFRSNPFLGSNKDKKGYILHSNVLVRFSARNTGKVHSILDGNGVLRILPGTGKSFLDGHLKAHHDLHATLELDQLPMNKSELPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSV8</accession>
    <name>A0A118JSV8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="3">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSV8"/>
    <dbReference type="STRING" id="59895.A0A118JSV8"/>
    <dbReference type="Gramene" id="KVH89427">
        <property type="protein sequence ID" value="KVH89427"/>
        <property type="gene ID" value="Ccrd_008579"/>
    </dbReference>
    <dbReference type="OMA" id="SIVWNYK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000046">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="886" mass="100342" checksum="79A9B76235F2AF37" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSX6</accession>
    <name>A0A118JSX6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005346">
        <property type="protein sequence ID" value="KVH88705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSX6"/>
    <dbReference type="STRING" id="59895.A0A118JSX6"/>
    <dbReference type="Gramene" id="KVH88705">
        <property type="protein sequence ID" value="KVH88705"/>
        <property type="gene ID" value="Ccrd_025987"/>
    </dbReference>
    <dbReference type="OMA" id="IDYLRFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050942">
        <property type="entry name" value="F-box_BR-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259:SF114">
        <property type="entry name" value="OS06G0707300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259">
        <property type="entry name" value="OS07G0183000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="73"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="46538" checksum="A5061173A8954726" modified="2016-04-13" version="1">MSTTVDWSELQPELIEAIGKKLRVHKDYVRFRAVCSNWRRSTTKTPKHLPCQLPWLMLPQSSNQNRQSHLRSFFSLSDNKIHRLSLPEASNIRRRCGSSHGWLVILEETPAVFLINPLTRVKHHLPPLSSFPNVTKFNFFDVGREYTLKTSDGDVYTCNLKEMRDSFIKKVVFSSSPSDEDSDYFALAILNQTGDLAYCKKGDSLWKFIDNAQSYCEDVVYHKGCFYAVSKYGTIAVCDISGPLPDVSFIPTPPQVGGDMQYLVSLEDELLLVTRYLELGFDVDQHQLDIFYKTTEFRVCKLVLNGPIWEIVSKLDEWALFVGENSSMAFRASDFQGCKGNRIYFTDDYSEWNYDGANGDHDLGVYDLEDGSVVALPCYPRKFYNGRRWPPPIWITPRVIEDSFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUS9</accession>
    <name>A0A118JUS9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(+)-lariciresinol reductase</fullName>
            <ecNumber evidence="5">1.23.1.1</ecNumber>
            <ecNumber evidence="6">1.23.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(+)-pinoresinol reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.23.1.1" evidence="5"/>
    <dbReference type="EC" id="1.23.1.2" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01004913">
        <property type="protein sequence ID" value="KVH91662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUS9"/>
    <dbReference type="STRING" id="59895.A0A118JUS9"/>
    <dbReference type="Gramene" id="KVH91662">
        <property type="protein sequence ID" value="KVH91662"/>
        <property type="gene ID" value="Ccrd_006321"/>
    </dbReference>
    <dbReference type="OMA" id="NPARMGD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010284">
        <property type="term" value="F:lariciresinol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010283">
        <property type="term" value="F:pinoresinol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902125">
        <property type="term" value="P:(+)-pinoresinol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902138">
        <property type="term" value="P:(-)-secoisolariciresinol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF47">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="9">
        <location>
            <begin position="258"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="552" mass="61749" checksum="FE9BC746C3DB07E9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUY1</accession>
    <name>A0A118JUY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004791">
        <property type="protein sequence ID" value="KVH93217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUY1"/>
    <dbReference type="STRING" id="59895.A0A118JUY1"/>
    <dbReference type="Gramene" id="KVH93217">
        <property type="protein sequence ID" value="KVH93217"/>
        <property type="gene ID" value="Ccrd_004729"/>
    </dbReference>
    <dbReference type="OMA" id="YTFMANI"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000013">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF72">
        <property type="entry name" value="PECTINESTERASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011120133" description="pectinesterase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="11">
        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="327" mass="36033" checksum="92E30666AD5DA225" modified="2016-04-13" version="1">MAVTYIVYHVLRVFVLVFILLDVCSASFSMAVTSSSTTDTVLIVVDQSGQGDYKTIQDAINAVASNNSELIYIWIKPGTYREKIVVPADKPFITLSGTEASNTIITWNDGGDIFNSPTLSVMASDFVARYLTIQNTFGMSGKAIALRVAGDRAALYGCRILSYQDTLLDDSGRHYYYNCYIEGATDFICGNAASLFESCHLHSLATTFGTITAQHRNSPFENTGFIFVGCKITGMGDGTVLGRPWGSCSRVIFAHTFMSNVISPEGWRGWDDPSKERSKRVGWSRELSHDESAPFLNKSMIGGRSWLRPTPTHFKKHLPRPIEDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV48</accession>
    <name>A0A118JV48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_004856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004794">
        <property type="protein sequence ID" value="KVH93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV48"/>
    <dbReference type="STRING" id="59895.A0A118JV48"/>
    <dbReference type="Gramene" id="KVH93099">
        <property type="protein sequence ID" value="KVH93099"/>
        <property type="gene ID" value="Ccrd_004856"/>
    </dbReference>
    <dbReference type="OMA" id="KAACACH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039495">
        <property type="entry name" value="TAF1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36720">
        <property type="entry name" value="TAF RNA POLYMERASE I SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36720:SF1">
        <property type="entry name" value="TAF RNA POLYMERASE I SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14929">
        <property type="entry name" value="TAF1_subA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="825" mass="94259" checksum="173B3638090CBB24" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV96</accession>
    <name>A0A118JV96_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine cleavage T-protein, C-terminal barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004809">
        <property type="protein sequence ID" value="KVH92707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV96"/>
    <dbReference type="STRING" id="59895.A0A118JV96"/>
    <dbReference type="Gramene" id="KVH92707">
        <property type="protein sequence ID" value="KVH92707"/>
        <property type="gene ID" value="Ccrd_005233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="32024" checksum="27B21C6A3A20527C" modified="2016-04-13" version="1">MLMMMIKNGLLTNDVRLFGEPVADEKASLVTPNVLALSARSLYAAMLTPQGRFLYDMFLYEPPRTNEKPDPSGSRRRSDQDEVVLLADVDCSVDIENVGEELCCWQRYGVDLHKRAPSDPEAASVGNTGGWQWHKDPRLNCLGFRGIFPSSVTRESIPLEYNFAGLNAISFDKGCYVGQELIARSHHRGVIRKRLLPLKFRNESGKEVAEPKVAPSSEVIASKSGKKVGIVTTVLGSRGLGLLRLNEAFKGPGNLVIKGQEDVKVEPIRPEWWPTEWFLEHEPHQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVE1</accession>
    <name>A0A118JVE1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_004983</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVE1"/>
    <dbReference type="STRING" id="59895.A0A118JVE1"/>
    <dbReference type="Gramene" id="KVH92949">
        <property type="protein sequence ID" value="KVH92949"/>
        <property type="gene ID" value="Ccrd_004983"/>
    </dbReference>
    <dbReference type="OMA" id="LTILARW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVH92949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="34166" checksum="127B5AF85847F2BE" modified="2016-04-13" version="1">MRETLASTSSSTTSDSTTPIESAWIDAHERLSPRWQSSALSPQPGLLFQYEAELDAFLEFLIWRFSIWVDKPTPGNALMNLRYRDERAMEMRGKIRTGLEGPGLTVPQKLWYCVATVGGQYIWTRLQSFSAFRQWGDSEQRSLARRAWFIVQRIEGFYKAASFTNLLVFLYTGRYRNLIERAIQARLVYGSPHMNRAVSFEYMNRQLEMLLLLLPLLNSSSMKNFLRPFSKDNSSGSAGDETLCPICQANPTTVYLALPCQHRYCYYCLRTRCAATPSFRCSRCNDPVVAMQRYGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVF5</accession>
    <name>A0A118JVF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVF5"/>
    <dbReference type="STRING" id="59895.A0A118JVF5"/>
    <dbReference type="Gramene" id="KVH92440">
        <property type="protein sequence ID" value="KVH92440"/>
        <property type="gene ID" value="Ccrd_005497"/>
    </dbReference>
    <dbReference type="OMA" id="MEINKFT"/>
    <dbReference type="OrthoDB" id="666348at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167:SF26">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="20618" checksum="628057799CBF622D" modified="2016-04-13" version="1">MDQSVQTYDKECMKMAMLKHEQTFKEQVYELHRLYQIQKMLMKNMQDQENICFNYQQQKNKLDLEQPATKDYAQDHVTETLNDQEIEEDECEIELTLGPTSFNRRRRTTNKPESSDSVPSFSSSSTGSSHIKRIERITRENSSFLSGNRRNNSSSSDRSLKQPPWMYQVLSLNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWE4</accession>
    <name>A0A118JWE4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The PPC domain mediates interactions between AHL proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004387">
        <property type="protein sequence ID" value="KVH95484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWE4"/>
    <dbReference type="STRING" id="59895.A0A118JWE4"/>
    <dbReference type="Gramene" id="KVH95484">
        <property type="protein sequence ID" value="KVH95484"/>
        <property type="gene ID" value="Ccrd_002452"/>
    </dbReference>
    <dbReference type="OMA" id="PRKQKHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039605">
        <property type="entry name" value="AHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500:SF7">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="6">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="35634" checksum="EB3386344924BBEE" modified="2016-04-13" version="1">MEGREGMNNSGVTVVRSDAPSDYHIAPRTEAPTTGSTVVTTQVVLSPAPPSTAVPPPLGVMPLSMKKKRGRPRKYGPDGSVTQALSPKPISSAGSSPVIDFSSGKRGKIRPPSAGKHHQHSSKIGLESLDRSIVTEFSVVWSGDWFSCSVGANFIPHIINVNAGEDVTMKVISFSQQGPRAICILSANGVISSVTLRQPDSSGGTLTYEGRFEILSLAGSFMASESGGIRNRSGGMSVSLASPDGRVVGGSVAGLLVAASPVQHEQKTAKKPKAEAGPPPAVAIPTSGGGGGSGDTEEEEEEAAAYGVKMKVSSAGAAVSSFRGGDNWYNNEKKASEMNMSGAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXH8</accession>
    <name>A0A118JXH8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004347">
        <property type="protein sequence ID" value="KVH96217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXH8"/>
    <dbReference type="STRING" id="59895.A0A118JXH8"/>
    <dbReference type="Gramene" id="KVH96217">
        <property type="protein sequence ID" value="KVH96217"/>
        <property type="gene ID" value="Ccrd_001704"/>
    </dbReference>
    <dbReference type="OMA" id="TRTNYEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="47"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="195" mass="22102" checksum="326CA3AB44ADAD76" modified="2016-04-13" version="1">MKTVVETFVRELLRPVFDRLQCLAGDRNPRGVPSNAARDELGGIKSYRSFRLLEELERGEKGIGDGTVSYGMDDADDVYMQSWTGTIIGPSNTVHEGRIYQLKLFCGHEYPEEPPSVKFQSRINMSCVNQETGVVEPSLFPMLADWQREYTMEDILTQLKKEMTSPQNRKLSQPPEGNEEGRVDPKGLVLRCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXY6</accession>
    <name>A0A118JXY6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXY6"/>
    <dbReference type="Gramene" id="KVH97734">
        <property type="protein sequence ID" value="KVH97734"/>
        <property type="gene ID" value="Ccrd_000133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="15798" checksum="9E925FBCA072F120" modified="2016-04-13" version="1" fragment="single">RERRKACFKICTSFPLFSLHLFFGNIIILKQISLHSLVPPATTVVPLSKFTLQLTNLNTPQQISKSPTFPTTQKPPSLTKLHTQKHESFIICKVPLDDCSQILQKETDTVYCITTTHHEKFSRVQATIRDGLFLHFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY24</accession>
    <name>A0A118JY24_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003816">
        <property type="protein sequence ID" value="KVH97869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY24"/>
    <dbReference type="STRING" id="59895.A0A118JY24"/>
    <dbReference type="Gramene" id="KVH97869">
        <property type="protein sequence ID" value="KVH97869"/>
        <property type="gene ID" value="Ccrd_000017"/>
    </dbReference>
    <dbReference type="OMA" id="ITHEHES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF93">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH97869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="36300" checksum="9E7EF57BD79E6FAB" modified="2016-04-13" version="1" fragment="single">EIESGLRQTHLSSSPSSSSSSSSSSLYRPQLLYYKDTLILLLTYLHTHLSSSSSSLSLSLSLSLSLYIYIYRYIFISFLMVLKEMDNFGVLRLPPGFRFHPTDEELVVQYLNRKVHSFPLPASIIPEVDVCKSDPWDLPGDLQQERFFFSSREVKYPNGNRSNRSTLSGYWKATGLDKQIVSWRNKQVVGMKKTLVFYKGKPPSGRRTDWIMHEYRLAAASPEAQGMEKWVVCRIFLKKRGKKEEEKQEKNVQKGKSNPIIFYDFMASKRKGDLPLLSSGSSGITTNTNTNTNTSEDDEEEQSSSKCYDVSTFRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K027</accession>
    <name>A0A118K027_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome b561, eukaryote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_021933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K027"/>
    <dbReference type="STRING" id="59895.A0A118K027"/>
    <dbReference type="Gramene" id="KVH99820">
        <property type="protein sequence ID" value="KVH99820"/>
        <property type="gene ID" value="Ccrd_021933"/>
    </dbReference>
    <dbReference type="OMA" id="DDKYDVP"/>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057443">
        <property type="entry name" value="At5g54830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045879">
        <property type="entry name" value="B561A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281:SF1">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159838" evidence="9">
        <location>
            <begin position="25"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="12">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="190"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="526"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="655"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH99820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="909" mass="101695" checksum="9C1552F8265EB0A3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1I5</accession>
    <name>A0A118K1I5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002611">
        <property type="protein sequence ID" value="KVI02938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1I5"/>
    <dbReference type="STRING" id="59895.A0A118K1I5"/>
    <dbReference type="Gramene" id="KVI02938">
        <property type="protein sequence ID" value="KVI02938"/>
        <property type="gene ID" value="Ccrd_018768"/>
    </dbReference>
    <dbReference type="OMA" id="KSITTHI"/>
    <dbReference type="OrthoDB" id="1925898at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36347">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36347:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19527" checksum="3C8819E166235687" modified="2016-04-13" version="1">MNSSILPFTKSITTHIFTSQKHHHHHLHRQPPTLLPIRTSSSDNTTATTTDDNPSPPSDKNAVQIKFRRGVRRKTRRDQENESNDKNMMMGRKKEVAKKEWEDMTVREKALELYVGEKGLLFWINKFAYASIYIIIGAWILFRFVGPALNLYQLDAPPLSPTDVLKGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1K5</accession>
    <name>A0A118K1K5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_018754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002610">
        <property type="protein sequence ID" value="KVI02957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1K5"/>
    <dbReference type="Gramene" id="KVI02957">
        <property type="protein sequence ID" value="KVI02957"/>
        <property type="gene ID" value="Ccrd_018754"/>
    </dbReference>
    <dbReference type="OMA" id="TTYLANW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057291">
        <property type="entry name" value="CHX17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF18">
        <property type="entry name" value="CATION_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23256">
        <property type="entry name" value="CHX17_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter central" evidence="13">
        <location>
            <begin position="466"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI02957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="687" mass="76050" checksum="BD4DB104FB72585C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K200</accession>
    <name>A0A118K200_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallothionein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_018092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Metallothioneins have a high content of cysteine residues that bind various heavy metals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallothionein superfamily. Type 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002338">
        <property type="protein sequence ID" value="KVI03601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI03601">
        <property type="protein sequence ID" value="KVI03601"/>
        <property type="gene ID" value="Ccrd_018092"/>
    </dbReference>
    <dbReference type="OMA" id="KMFYERS"/>
    <dbReference type="OrthoDB" id="1111048at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000347">
        <property type="entry name" value="Metalthion_15p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33543">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33543:SF37">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01439">
        <property type="entry name" value="Metallothio_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI03601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="7528" checksum="C7D4FEECB78F56F2" modified="2016-04-13" version="1">MSCSSGKCNCGSSCSCGSSCNCNSADIERSTTTTMIVDGVVPQMTYAEGTETSFAVEGGNGCKCGGNCXCDPCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K379</accession>
    <name>A0A118K379_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K379"/>
    <dbReference type="STRING" id="59895.A0A118K379"/>
    <dbReference type="Gramene" id="KVI05536">
        <property type="protein sequence ID" value="KVI05536"/>
        <property type="gene ID" value="Ccrd_016190"/>
    </dbReference>
    <dbReference type="OMA" id="MIKNYRQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="28748" checksum="B13ECF5BFB826631" modified="2016-04-13" version="1">MSNEKERENHVYLAKLAEQAERYEEMVESMKSVAKLNVELTVEERNLLSVGYKNVIGARRASWRIMSSIEQKEESKGNEGNVNLIKGYRKKVEDELSKICSDILDIIDKHLIPSSGSGEATVFYYKMKGDYYRYLAEFKTDQERKDAAEQSLKGYEAHLPSTHPIRLGLALNFSVFYYEIMNSPERACHLAKQAFDEAIAELDSLSEESYKDSTLIMQLLRDNLTLWTSDLPEDGGEEAAAVMGETRKAHGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K430</accession>
    <name>A0A118K430_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oligosaccaryltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_014716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001540">
        <property type="protein sequence ID" value="KVI06933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K430"/>
    <dbReference type="STRING" id="59895.A0A118K430"/>
    <dbReference type="Gramene" id="KVI06933">
        <property type="protein sequence ID" value="KVI06933"/>
        <property type="gene ID" value="Ccrd_014716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044165">
        <property type="entry name" value="OST4_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28677">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28677:SF4">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI06933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17160" checksum="EA38BBEB712B8792" modified="2016-04-13" version="1">MTNLKSSNSIGGNGGVCTAHALELEVLLQVQYKEAADLLEEEEEENHFERKSIWMEFEKDDEKMKVYSISFLNTSSFTAQLIGVQARVDYVSSICLKLVLPRSPTRQQQYANLWMMSDGDLGFMANFLGIFIFALVIAYHYVLADPKYEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5D2</accession>
    <name>A0A118K5D2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BTB/POZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5D2"/>
    <dbReference type="STRING" id="59895.A0A118K5D2"/>
    <dbReference type="Gramene" id="KVI08913">
        <property type="protein sequence ID" value="KVI08913"/>
        <property type="gene ID" value="Ccrd_012705"/>
    </dbReference>
    <dbReference type="OMA" id="KWNILAR"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009751">
        <property type="term" value="P:response to salicylic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1020.10:FF:000004">
        <property type="entry name" value="BTB/POZ and TAZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000012">
        <property type="entry name" value="BTB/POZ and TAZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044513">
        <property type="entry name" value="BT1/2/3/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46287">
        <property type="entry name" value="BTB/POZ AND TAZ DOMAIN-CONTAINING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46287:SF11">
        <property type="entry name" value="BTB_POZ AND TAZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="7">
        <location>
            <begin position="246"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="44144" checksum="A8C6B64AA6E05D26" modified="2016-04-13" version="1">MNNSCKETPSIGKKLELVSPLHGTSTIVVGHPVLSTTSIGHPKGCTLSKNKSSWMQRNCCTSLAMIELWDRLFDEAYRADVKIHTDNGTIIYAHASILGFASPVFRSMFKKSRSRGIISIPIRGVPAEAVRIFIRFLYTSCYEQAQVEEHVLSLLVLSHAFAVPKLKRECEYQLEHLLLNVDNVVDVFQLALLCDAPRLSIICHRFMLRSFNAVSSSAGWKAMRESHPALEKELLESVREEDRRQKEKMRKREERKIYAELYEAMEALVEICRDKVQKEDQKACKYEGCRGLESLVRHFYGCKLRVSGGCPHCKRMWQLLELHARLCANSNACRVPLCRRFKQKIAKANKKKRKKKDETKWNILARKVLRSKSITGAPYFRLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5L4</accession>
    <name>A0A118K5L4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_012345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5L4"/>
    <dbReference type="STRING" id="59895.A0A118K5L4"/>
    <dbReference type="Gramene" id="KVI09223">
        <property type="protein sequence ID" value="KVI09223"/>
        <property type="gene ID" value="Ccrd_012345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000002">
        <property type="entry name" value="cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="66" mass="7640" checksum="B92340334FBD3DD5" modified="2016-04-13" version="1">MPKRSSLLDGPYRILGRRNCVNVTFVILGAFFGERAVDYGVRKLWERNNVGKRFEDITVLGQRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K607</accession>
    <name>A0A118K607_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">Glutamate 5-kinase</fullName>
                <shortName evidence="17">GK</shortName>
                <ecNumber evidence="17">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="17">GPR</shortName>
                <ecNumber evidence="17">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_011743</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="17"/>
    <dbReference type="EC" id="1.2.1.41" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01001038">
        <property type="protein sequence ID" value="KVI09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K607"/>
    <dbReference type="STRING" id="59895.A0A118K607"/>
    <dbReference type="Gramene" id="KVI09858">
        <property type="protein sequence ID" value="KVI09858"/>
        <property type="gene ID" value="Ccrd_011743"/>
    </dbReference>
    <dbReference type="OMA" id="DAHKWAP"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000013">
        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 17" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="19">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="18">
        <location>
            <begin position="287"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="687" mass="74670" checksum="597ED9777E172C45" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBN5</accession>
    <name>A0A124SBN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005068">
        <property type="protein sequence ID" value="KVH91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBN5"/>
    <dbReference type="STRING" id="59895.A0A124SBN5"/>
    <dbReference type="Gramene" id="KVH91210">
        <property type="protein sequence ID" value="KVH91210"/>
        <property type="gene ID" value="Ccrd_006763"/>
    </dbReference>
    <dbReference type="OMA" id="NFLWHIS"/>
    <dbReference type="OrthoDB" id="1430376at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051955">
        <property type="entry name" value="PME_Inhibitor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080:SF12">
        <property type="entry name" value="PLANT INVERTASE_PECTIN METHYLESTERASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176126" evidence="2">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="3">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23184" checksum="688AB774AE38EE08" modified="2016-04-13" version="1">MAQMNLSLLVLFFTFLGFLGTIESRSRARSYLEAQCRSTLYSDLCVRTLLPYTSKRVVPSPQKIAQVSLATCLSKARVTKAYVDVIAEQFKKTKNLGEYHAVKDCLQQINNGVNQITQSVKELRQMGTDGEEKFVWHESNVQSWVSAALTDTTTCIDGILGDEIGSREKRMIKARFLNVKQLASNSLALFNRFTAKHRASRAVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBX2</accession>
    <name>A0A124SBX2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_005963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004885">
        <property type="protein sequence ID" value="KVH92007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBX2"/>
    <dbReference type="STRING" id="59895.A0A124SBX2"/>
    <dbReference type="Gramene" id="KVH92007">
        <property type="protein sequence ID" value="KVH92007"/>
        <property type="gene ID" value="Ccrd_005963"/>
    </dbReference>
    <dbReference type="OMA" id="EVMAMAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000043">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF515">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH92007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="372" mass="41835" checksum="0C0409D1FC672230" modified="2016-04-13" version="1">MGVLILIATSFSLYKVVLKMKDKRQKARFFKRNGGLLLKQQESADESLVDKTTLFTAKELEKATDYFNENRVLGRGGQGTVYKGMLTDGRIVAVKRSKIVDESQLEQFINEVVILSQVNHRNVVKLLGCCLETEVPLLVSEFISNGTLFEHIHDESDEFPLTLNTRLRIATEIAGALAYLHSATSIPIYHRDIKSTNILVDDKYRAKVSDFGTSRFVSIDQTHLTTLVKGTFGYLDPEYFQSSQFTEKSDVYSFGVVLVELLTGERPISLTRFGEHRSLATHFMSAMEEGRVMSVMDGRIVNEGCRGEVMAMANLAMQCLNLNGKNRPTMKEVASELESIRAAHVPSAIQTDFRKSKYEAGEEEELIMLSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDA1</accession>
    <name>A0A124SDA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpene synthase, metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004338">
        <property type="protein sequence ID" value="KVH96280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDA1"/>
    <dbReference type="STRING" id="59895.A0A124SDA1"/>
    <dbReference type="Gramene" id="KVH96280">
        <property type="protein sequence ID" value="KVH96280"/>
        <property type="gene ID" value="Ccrd_001646"/>
    </dbReference>
    <dbReference type="OMA" id="DITNEIC"/>
    <dbReference type="OrthoDB" id="1921927at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF214">
        <property type="entry name" value="(3S,6E)-NEROLIDOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="253"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="555" mass="63642" checksum="F4088AEA24B5A60F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SER9</accession>
    <name>A0A124SER9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003155">
        <property type="protein sequence ID" value="KVI00962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SER9"/>
    <dbReference type="STRING" id="59895.A0A124SER9"/>
    <dbReference type="Gramene" id="KVI00962">
        <property type="protein sequence ID" value="KVI00962"/>
        <property type="gene ID" value="Ccrd_020774"/>
    </dbReference>
    <dbReference type="OMA" id="CGFKMRQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF47">
        <property type="entry name" value="OS07G0564800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="393" mass="46088" checksum="1C95E2811C65BF80" modified="2016-04-13" version="1">MFFILTAAFWYESIYKLVLLMREAKSWRNLLRKRRLHFDWGRYGVKMKPFMGAACIIMLYIVYRTTNYQYLETELDSRFDPLYTSKDYVLASTSLKGLPRGIIEAKSDLELKPLWSTSSLKSKKGDASSTHNLLAIPVGLKQKRNVNTIVQKFLTENFTVILFHYDGKVDGWRDLEWNNKVIHIVAQNQTKWWFAKRFLHPAAVSIYDYIFLWDEDLGVQHFNPRSYLDIVKAEGLEISQPALDPNSTDIHHRITIRKRMNKFHRRVFVEGMAPVFSRAAWHCAWHLIQNDLVHGWGMDMKLGYCAQGDRSKKVGVVDSEFIIHQGIQTLGGASAKKTTNHVDLMKKHGVDVRAEIRRQSTTELQIFKQRWEKAVKEDTDWVDPFYRRKQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFK0</accession>
    <name>A0A124SFK0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002349">
        <property type="protein sequence ID" value="KVI03481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFK0"/>
    <dbReference type="STRING" id="59895.A0A124SFK0"/>
    <dbReference type="Gramene" id="KVI03481">
        <property type="protein sequence ID" value="KVI03481"/>
        <property type="gene ID" value="Ccrd_018215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="19452" checksum="C08675884C729DF8" modified="2016-04-13" version="1" fragment="single">MYSSRGSNAYGQQQQQQPKPQSYSSQSAYGQNLGPDTASQMSIASRHSALLGGHSSAGAHYGGQYTSVYGSTALNSALQVPATSAKGAGPSVLEGRSGYGSTLQESSKFTSGDYPAASQKEEISETDLGYRTAAGRILYLLPKSLAAWWTLSIRRLPSSFNRSVNEAIVAWCPRYVVEAAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGR4</accession>
    <name>A0A124SGR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001509">
        <property type="protein sequence ID" value="KVI07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGR4"/>
    <dbReference type="Gramene" id="KVI07216">
        <property type="protein sequence ID" value="KVI07216"/>
        <property type="gene ID" value="Ccrd_014406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009943">
        <property type="entry name" value="DUF1475"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36318">
        <property type="entry name" value="OS06G0581300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36318:SF4">
        <property type="entry name" value="REVERSE TRANSCRIPTASE, RNA-DEPENDENT DNA POLYMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07343">
        <property type="entry name" value="DUF1475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10437" checksum="71650E822703250E" modified="2016-04-13" version="1">MAAAAAASVGIAVKTLFIVLFITMVASFAYLLTIDGLGSCFNLNARWMVAGVTDFTIKIVVIGAWLVYKESNLMVPVALIASAFLLGRCGWHIRNQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHD4</accession>
    <name>A0A124SHD4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHD4"/>
    <dbReference type="STRING" id="59895.A0A124SHD4"/>
    <dbReference type="Gramene" id="KVI09198">
        <property type="protein sequence ID" value="KVI09198"/>
        <property type="gene ID" value="Ccrd_012371"/>
    </dbReference>
    <dbReference type="OMA" id="EVAYMQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="47"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="39844" checksum="87275CF9DB15D38F" modified="2016-04-13" version="1">MATKAVHVSDVPNLDHVPENAASLSLYATRRPTGVDVSKNGKSFPKFTVIGHRGHGMNILQSTDRRMKAFKENSILSFNNAAKHPIDYIEFDVQGTVFEKRATDLTINEFFSYGPQREAGKEGKSLVRKVNGKIVGWDVESDDHLCTLQEAFQKVNPCIGFNIELKFDDNVVYEQDHLIHVLQVIMKVVSENAKDRPIIFSSFQPDAALLMKKLQHRYPVYFLTNGGNEVYDDVRRNSLEEAKKLALEGRLDGIVSEVKAIFRNPSVVREIKGSNLSLLTYGKLNNFSETVHVQQLMGVDGVIVDLVEEITRAIGETKTRKGSDDEKREKTDEEDGRGIELSFLLNLISQVIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103DTN7</accession>
    <name>A0A103DTN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011267">
        <property type="protein sequence ID" value="KVE11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVE11866">
        <property type="protein sequence ID" value="KVE11866"/>
        <property type="gene ID" value="Ccrd_024061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF573">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVE11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="112" mass="13535" checksum="F1F2038F597FD6A5" modified="2016-04-13" version="1">MKNLRILRICDEELRNVWHTFDLRLWKVNYHGKLKFLSNKLRLLYWHXFPFKCFPSDFYPEDIVAIDLSYSHIKNLWTTPKVDMRRASGPDGGLQFLNLHGYQVRCNIPKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VVY4</accession>
    <name>A0A103VVY4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006659">
        <property type="protein sequence ID" value="KVH61066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VVY4"/>
    <dbReference type="Gramene" id="KVH61066">
        <property type="protein sequence ID" value="KVH61066"/>
        <property type="gene ID" value="Ccrd_025659"/>
    </dbReference>
    <dbReference type="OMA" id="RWRFERP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007789">
        <property type="entry name" value="DUF688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35466:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35466">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05097">
        <property type="entry name" value="DUF688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH61066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="17066" checksum="54F80D7E6DE55884" modified="2016-04-13" version="1">MAVDDSFKKPGAVPFKWEIRPGVPKLPEHDQPTPSNHHLKPPPATPTPLFRFPSSPWTTQSNGFCFDNPIMVGGPEVVSSSGCFPSRKRDQRKTNKLHVYKSDLDTLSQWSMSTQKSPSPFRDSPFSSSSFSSSYLSSPWMVSDVEWAGFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC06</accession>
    <name>A0A103XC06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005699">
        <property type="protein sequence ID" value="KVH87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC06"/>
    <dbReference type="Gramene" id="KVH87930">
        <property type="protein sequence ID" value="KVH87930"/>
        <property type="gene ID" value="Ccrd_024755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="240" mass="26844" checksum="3543DA2B5E7C1CEF" modified="2016-04-13" version="1">MQLRGPLVGPDRWWYHTLLKGTVHETLASYDSIPKSGPPFSLTNGSSNQLVLPFYFSVAFACFQVQALAVEASRQKRTSGPGRSQKSIALAEPYLAGAEATATQIKNESRNKTLALERVQRHSGPTTIQVMSDSEAKLDRLFYVVAAPIVGQRTYRDAYGPIYDVSIADVRQASHMDWPGSSSANETSISKPSEYLFDRRLYLYVEFTSDRSRPVSLSFLRRLPTHEIIQCQLLDTHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDJ7</accession>
    <name>A0A103XDJ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005342">
        <property type="protein sequence ID" value="KVH88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDJ7"/>
    <dbReference type="STRING" id="59895.A0A103XDJ7"/>
    <dbReference type="Gramene" id="KVH88744">
        <property type="protein sequence ID" value="KVH88744"/>
        <property type="gene ID" value="Ccrd_025865"/>
    </dbReference>
    <dbReference type="OMA" id="PKCPNVK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF139">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="84"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="422" mass="46530" checksum="8EBB06F8916E116C" modified="2016-04-13" version="1">MGCLISHLAAKFAFFPPSPPTYQIKKRDDGKPIAVYSSSSIPLTGGGLDDGGGGGAGCSLDVLSINTKRGNKIVAFYLKNPYARLTLLYSHGNAADLGQLFDLFVQLKANLRVNLMGYDYSGYGASTGKPSELNTYADIEAVYECLQTEYGVSQEDLILYGQSVGSGPTLHLAARLPRLRGVVLHSAILSGLRVVCHVKCTLCFDIYKGTEDDVVNWLHGNGLWKMAKDPYEPLWIKGGGHCNLELYPDYIRHLCRFIYEMETITTKTRLTKIKSTLRIPKKSNPDTRSCCCIKPRLPDCLKCPRPRCPSCPECCKPSCCFLNWKCGCCWTMKLPKCPNVKLPKCPNVKLPKCPNVKLPKCPNVKLPKCPNVKLPKCPNVKLPRCPNVKLPKCPDVKLSKCASCLRCGCLACSCKCVNCSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDW6</accession>
    <name>A0A103XDW6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005327">
        <property type="protein sequence ID" value="KVH88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDW6"/>
    <dbReference type="STRING" id="59895.A0A103XDW6"/>
    <dbReference type="Gramene" id="KVH88878">
        <property type="protein sequence ID" value="KVH88878"/>
        <property type="gene ID" value="Ccrd_024887"/>
    </dbReference>
    <dbReference type="OMA" id="PQFNYPN"/>
    <dbReference type="OrthoDB" id="1424968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000006">
        <property type="entry name" value="NAC domain-containing protein 100-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF115">
        <property type="entry name" value="NAC DOMAIN CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="38089" checksum="2BE6CA12888E9FEF" modified="2016-04-13" version="1">MEGEVNKEAETLPPGFRFHPTDEELITSYLINKISDSSFTGRAITDVDLNKCEPWDLPGKAKMGEKEWYFFSLRDRKYPTGVRTNRATNTGYWKTTGKDKEIFNGVTSELVGMKKTLVFYRGRAPRGEKTNWVMHEYRVHAKSAFRTSKDEWVVCRVFQKTAGGKKYPSSSSSHSRGMINPYNLDIGPASGIHMPPSDPTASYQFPVGLGRTYMNNADLSEFSRVFRGNTNMPLHQTQMNYPNGGGAECFTISGLNLNLRGSTSAPMRPMGGAQPPLPLPPYPQEDVTSSMLINSCGLGNEQSMGYGGDMSSNANNNRFMTMEQCADLDNYWAPYGLPINEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XED9</accession>
    <name>A0A103XED9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005307">
        <property type="protein sequence ID" value="KVH89151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XED9"/>
    <dbReference type="Gramene" id="KVH89151">
        <property type="protein sequence ID" value="KVH89151"/>
        <property type="gene ID" value="Ccrd_008866"/>
    </dbReference>
    <dbReference type="OMA" id="FIMQDEL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14479">
        <property type="entry name" value="SPX-MFS_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045264">
        <property type="entry name" value="SPXM_SPX_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF21">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="598" mass="67298" checksum="E6BAA6181DBA7F09" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF05</accession>
    <name>A0A103XF05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005208">
        <property type="protein sequence ID" value="KVH89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF05"/>
    <dbReference type="STRING" id="59895.A0A103XF05"/>
    <dbReference type="Gramene" id="KVH89492">
        <property type="protein sequence ID" value="KVH89492"/>
        <property type="gene ID" value="Ccrd_008518"/>
    </dbReference>
    <dbReference type="OMA" id="CREMIKN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF611">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118738" evidence="5">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="41900" checksum="49DD7CB1D2CA3532" modified="2016-04-13" version="1">MAISSSFPFLPFCLLLWAFTVYANGCYTSIISFGDSLADTGNLKQLVAKSNGRPPHFMYPPYGETFFHNPTGRCSNGRLIIDFLAENLGMSLIPPYESVKSSMEVIEKGQGVNFAVAGATALDSAFHEAQGVYNAYTNASLNVQLGWFKRSLPAICGNPSDCKNWIKKSLILMGEIGGNDYNHPVIAGKSLEELKSYVPLELIELGAETLVVPGNLPIGCSAAYLTIYYGAQKDEYDNATGCLIKLNKFAECHNELLQTELNRIRELHPNVNVIYADYYNAAMQFFQSPEKYGFTNGALTACCGGGGPYNYNRSVACGYPLSTSCSQPETYANWDGLHLTEAAYQVIYKSLFQGTYTTPRFNSVCPTSMVQAKDASSSSVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFB4</accession>
    <name>A0A103XFB4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_008398</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01005195">
        <property type="protein sequence ID" value="KVH89612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XFB4"/>
    <dbReference type="Gramene" id="KVH89612">
        <property type="protein sequence ID" value="KVH89612"/>
        <property type="gene ID" value="Ccrd_008398"/>
    </dbReference>
    <dbReference type="OMA" id="KGLMGQY"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057297">
        <property type="entry name" value="RDR6-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057298">
        <property type="entry name" value="RDR6-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058751">
        <property type="entry name" value="RDRP_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF18">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24572">
        <property type="entry name" value="RBD_RDR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24577">
        <property type="entry name" value="RDR6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26252">
        <property type="entry name" value="RdRP_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 14" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA-dependent RNA polymerase 6-like RNA-binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-dependent RNA polymerase 6-like second" evidence="11">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="406"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH89612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1182" mass="134759" checksum="99B4865304945E7B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFG8</accession>
    <name>A0A103XFG8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005138">
        <property type="protein sequence ID" value="KVH89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFG8"/>
    <dbReference type="STRING" id="59895.A0A103XFG8"/>
    <dbReference type="Gramene" id="KVH89790">
        <property type="protein sequence ID" value="KVH89790"/>
        <property type="gene ID" value="Ccrd_008195"/>
    </dbReference>
    <dbReference type="OMA" id="NYIREAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF100">
        <property type="entry name" value="PROTEIN ENHANCED DISEASE RESISTANCE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="246"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="91621" checksum="4FEB4FE3501CA21A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG02</accession>
    <name>A0A103XG02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG02"/>
    <dbReference type="STRING" id="59895.A0A103XG02"/>
    <dbReference type="Gramene" id="KVH90058">
        <property type="protein sequence ID" value="KVH90058"/>
        <property type="gene ID" value="Ccrd_007908"/>
    </dbReference>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000033">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="91"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="39023" checksum="9AF69DFCEFAFEB39" modified="2016-04-13" version="1">MSRAIPKRKEKLEISLLKTNIPPLVLLKTHRYSRFLCLKSSTNIMREILHIQGGQCGNQIGAKFWEVVCAEHGIDSTGRYNGDQDLQLERVNVYYNEASCGRFVPRAILMDLEPGTMDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSWNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEYEEEEEGYEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH17</accession>
    <name>A0A103XH17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAPP III complex, Trs85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH17"/>
    <dbReference type="STRING" id="59895.A0A103XH17"/>
    <dbReference type="Gramene" id="KVH90542">
        <property type="protein sequence ID" value="KVH90542"/>
        <property type="gene ID" value="Ccrd_007408"/>
    </dbReference>
    <dbReference type="OMA" id="PCSPFMW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="18619" checksum="732D349FE3A2CCBC" modified="2016-04-13" version="1">MNVSTKRPIWWLLDGPRIVHYNFSDSFCETKLKMTLHNSSGFVASVRVNTFDSPPGSAPSGSKLGWHDMSSPPIDIRVPAPDISGSSTGKAVSLESVPPFIWSGSSTTRVKLEPNSTTEISLLVTTFAPGTYDLSNYTLHWNLEESSNGREREGTCQGHPFYLTILQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHH2</accession>
    <name>A0A103XHH2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005093">
        <property type="protein sequence ID" value="KVH90800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHH2"/>
    <dbReference type="STRING" id="59895.A0A103XHH2"/>
    <dbReference type="Gramene" id="KVH90800">
        <property type="protein sequence ID" value="KVH90800"/>
        <property type="gene ID" value="Ccrd_007206"/>
    </dbReference>
    <dbReference type="OMA" id="HQETNIN"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000554">
        <property type="entry name" value="protein indeterminate-domain 12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000131">
        <property type="entry name" value="protein indeterminate-domain 5, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055186">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF163">
        <property type="entry name" value="ZINC FINGER C2H2-TYPE_INTEGRASE DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22996">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="49757" checksum="85D98B6C3A50CC28" modified="2016-04-13" version="1">MMSGGDGFNSSSPSSLTASLIQDPISNPNPNSSSSAKRKRNLPGTPDPDAEVIALSPRSLMATNRFVCEICNKGFQRDQNLQLHRRGHNLPWKLKQRNKLEVVKKKVYICPEKSCVHHDPSRALGDLTGVKKHFSRKHGEKKWKCEKCSKKYAVQSDWKAHSKICGTREYKCDCGTLFSRKDSFITHRAFCDALTEENSRMASFPMMSSTAHLNFRNDLMMINGGGGGGQLRFPGMFGGGMLESTNLDANGAKPRLPIWLDQHGNESHLENPSNSSFLGSSSSNNNNNGGILPSEMVQWLNGGQETVATYSGLHLKEEDNKGEMQFNSLYNNYTTSNTTPPPPPPPPPPAHMSATALLQKAAQMGSTRSTNGGATDQGFGLMTTSLSNFSSSNHHDINGDGLMMMMTGSKQSKGNESISHDGNLTRDFLGVGGNERRPFDLQQELFNFSSSMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIW2</accession>
    <name>A0A103XIW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_006457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004932">
        <property type="protein sequence ID" value="KVH91519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XIW2"/>
    <dbReference type="Gramene" id="KVH91519">
        <property type="protein sequence ID" value="KVH91519"/>
        <property type="gene ID" value="Ccrd_006457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="8">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH91519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="152" mass="17047" checksum="65DA82510B527FDC" modified="2016-04-13" version="1">MVHFGVRCQQARNQHNHVKHLHPRSSHTPEASIYHYLPLPEAFKSHCARSESTREADGSRPQSTVDSRQQSIVGRQSTAINRRPSAVGSSQSSVGKGIDESQEAIKTGYVSGKIRXSFIRILPGDXVKIEVSRYDSTRGRIIYRLQNKDSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ34</accession>
    <name>A0A103XJ34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004910">
        <property type="protein sequence ID" value="KVH91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ34"/>
    <dbReference type="STRING" id="59895.A0A103XJ34"/>
    <dbReference type="Gramene" id="KVH91700">
        <property type="protein sequence ID" value="KVH91700"/>
        <property type="gene ID" value="Ccrd_006277"/>
    </dbReference>
    <dbReference type="OMA" id="ANQEYHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF181">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="600" mass="68532" checksum="E5062FCB15BC4BF1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJD6</accession>
    <name>A0A103XJD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thaumatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJD6"/>
    <dbReference type="STRING" id="59895.A0A103XJD6"/>
    <dbReference type="Gramene" id="KVH91876">
        <property type="protein sequence ID" value="KVH91876"/>
        <property type="gene ID" value="Ccrd_006099"/>
    </dbReference>
    <dbReference type="OMA" id="NGQGSCQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000003">
        <property type="entry name" value="Thaumatin I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017949">
        <property type="entry name" value="Thaumatin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00316">
        <property type="entry name" value="THAUMATIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118832" evidence="3">
        <location>
            <begin position="25"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="449" mass="48770" checksum="A2929128FFFC9043" modified="2016-04-13" version="1">MSRLKKCLILFIFIYICCFIFVQGTDFDIVNQCPYTVWAAASPGGGKRLETGERWPVKVQPGTDKARIWGRTGCNFDANGKGKCDTGDCNGMLECQDLGAPPNMVAELIPGANNLDFIDMSVINGFNVPMEFSPVGAPCKTIKCNADIIGQCPEKLRTKGGCNNACVVFKTAQYCCPVATMCGPNEYSKFFKERCPDTYTYPNDDQTGLVTCPSGYLPYILNMSSVKNYSIPLLVLCVFFFTFGQGANFDVVNQCPYTVWAAASPGGGKRLETGQTWPVVVAPGTAKARIWGRTGCTFDASGKGKCDTGDCNGMLECQGYGAPPNTLAELALNQDSNNDFVDISVVDGFNIPMEFSPVGASCKTMRCADPNINAQCPEKLRTKGGCNNPCTVFKTVEYCCTIEYGSCGPTEYSKFFKDRCPDAYSFPQDDKTSLFTCPGGTNYKVVFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJS0</accession>
    <name>A0A103XJS0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004873">
        <property type="protein sequence ID" value="KVH92031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJS0"/>
    <dbReference type="Gramene" id="KVH92031">
        <property type="protein sequence ID" value="KVH92031"/>
        <property type="gene ID" value="Ccrd_005941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18273" checksum="7A85E07FD8AD03EB" modified="2016-04-13" version="1">MGSSTLIQSSNSYVTQFTQSVAAFSQFREPYESTSSPGSVEVSSDVVIKFNGTGPLTLAEVTEEIGGSPNYEIDYALERIREQLCEYGTAQQYQQQSEGEFSITSQLTSIWDDVLIYNGNAVGDGSQKNFVCPSDRNGVLLPQLRRDLVEEQEKYNYGYTSANND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP29</accession>
    <name>A0A103XP29_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FLC EXPRESSOR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_003837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FLX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004570">
        <property type="protein sequence ID" value="KVH94094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP29"/>
    <dbReference type="STRING" id="59895.A0A103XP29"/>
    <dbReference type="Gramene" id="KVH94094">
        <property type="protein sequence ID" value="KVH94094"/>
        <property type="gene ID" value="Ccrd_003837"/>
    </dbReference>
    <dbReference type="OMA" id="GPYDMQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040353">
        <property type="entry name" value="FLX/FLX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405:SF17">
        <property type="entry name" value="PROTEIN FLC EXPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405">
        <property type="entry name" value="PROTEIN FLX-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH94094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33353" checksum="52737F8F9D536F7A" modified="2016-04-13" version="1">MSGRHYISSDALKYRQDSRPHRPLRESPPRHHPAEDRIAVHHREIQSLLVDNQRLAATHVALKQELSLALQDLRHLSSAAGNVKADRDAEVREVYEKAVKMEAEVRLIDELSAELVQVRGDVQKLSSERKELNEKLDQVHGDLAKERSKAHQIPLIKAEIDAMHKELQRGRAAVEYEKKVYASNIEQSQAMEKSMISMSREIEKLQAELANADKRARATAAAAAAATPGTGYAAGFGNHDMGYGGNAYPGNYAAHQVQGGVDPQYGHGPYDMQHRMVDAQYGPGGVPRGPYDMQHPNNAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSA7</accession>
    <name>A0A103XSA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001923</name>
        <name evidence="2" type="ORF">Ccrd_026142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007513">
        <property type="protein sequence ID" value="KVG86056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSA7"/>
    <dbReference type="STRING" id="59895.A0A103XSA7"/>
    <dbReference type="Gramene" id="KVG86056">
        <property type="protein sequence ID" value="KVG86056"/>
        <property type="gene ID" value="Ccrd_026142"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH95978">
        <property type="protein sequence ID" value="KVH95978"/>
        <property type="gene ID" value="Ccrd_001923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG86056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="102" mass="12071" checksum="C3A76CD100950E5B" modified="2016-04-13" version="1">MFSCRFLRILHAKHVFERILFTSEVSNIRKGNFAIYVGERKRRRFVVPISYLEHPLFQKLLYEAEKEFGFVHPMGRIVIPCRVETFINLVGILNCSGEARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSD6</accession>
    <name>A0A103XSD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_001917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004365">
        <property type="protein sequence ID" value="KVH96013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSD6"/>
    <dbReference type="STRING" id="59895.A0A103XSD6"/>
    <dbReference type="Gramene" id="KVH96013">
        <property type="protein sequence ID" value="KVH96013"/>
        <property type="gene ID" value="Ccrd_001917"/>
    </dbReference>
    <dbReference type="OMA" id="KMERNEG"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000101">
        <property type="entry name" value="Probable glycosyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH96013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="433" mass="50409" checksum="736B407C4816C44E" modified="2016-04-13" version="1">MVAFHHLGWRKPAIRILDRPSVFLAGAVSALLLLWGCFFFSTLDSIPFFSRSKSGLCNCNQPNPAFNLQFDPPVSTFYDDPSFGYTVDKRITNWDQKRRTWLGLHPSFEPRSHERVFIVTGSRSTPCKSPTGDHFLLRFYRNKVDYCRIHGYDIFYNNVLLDPKMPSCWAKIPAVRAAMLAHPEAEWIWWLDEDAAFTDMEYKLPLQRYKDYNFIVHGWPKEVYVKKSWLGLNAGSFLIRNCQWSLDLLDSWADMGPRSPNFDKWAGILMNEFKHESDDQTALAYLLLKEHQQWGTKRMHIETGYYLEGYWVLIVDTLKNITERYLEIETTTGMLRRRHAEKVSERYGVLREPSLKDAGNEFGSWRRPFVTHFAGCQPCNGKHNPLFTGKRCRDAMNIALNFADNQVLRNYGFVHRNLSDSSVVSPLPFDYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSY1</accession>
    <name>A0A103XSY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004335">
        <property type="protein sequence ID" value="KVH96305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSY1"/>
    <dbReference type="STRING" id="59895.A0A103XSY1"/>
    <dbReference type="Gramene" id="KVH96305">
        <property type="protein sequence ID" value="KVH96305"/>
        <property type="gene ID" value="Ccrd_001620"/>
    </dbReference>
    <dbReference type="OMA" id="WLDDQIP"/>
    <dbReference type="OrthoDB" id="781489at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34539">
        <property type="entry name" value="T6J4.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34539:SF19">
        <property type="entry name" value="T6J4.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="19972" checksum="9BC2CD4309184105" modified="2016-04-13" version="1">MESLSNKKRVRSDSDESEFNSPEAKRIRDDLLDTLDDSDVCTVGQDLDSFIKSFQDEISPPPETVDLASESGESRPDLEFLFEASDDELGLPPTGTTPNDSERIPVSTESVEVGEFCWLDDQIPNYDSFEYGFDYAAEDVNFNNNHNGEYVALDGLFDYTDLGFGSSDLSRRPESLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT46</accession>
    <name>A0A103XT46_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004311">
        <property type="protein sequence ID" value="KVH96423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT46"/>
    <dbReference type="STRING" id="59895.A0A103XT46"/>
    <dbReference type="Gramene" id="KVH96423">
        <property type="protein sequence ID" value="KVH96423"/>
        <property type="gene ID" value="Ccrd_001488"/>
    </dbReference>
    <dbReference type="OMA" id="LSEIAMW"/>
    <dbReference type="OrthoDB" id="909678at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34188">
        <property type="entry name" value="OS01G0299500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34188:SF23">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24062" checksum="C3DBBA23908F3E63" modified="2016-04-13" version="1">MDCDPPRDPDFVIDLESGTGDPSSDENLPKTDFSRLSDQLMSVDDDLENNVKVVIDSKVEVGKKMGKDKRKKGSSAKKPPKPPRPPRGCFSLDAADQKLIKELAELAIIKRARIERMKALKHKKALRASSSSSSSSMNGSLFAMLFTIIFFLMILLQGMSCRNPTSQGSPKTAQTNENGLIFIQEQLNPSASDSILPDSKSSNLLEKISGSGSGSGKSTVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUH4</accession>
    <name>A0A103XUH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003865">
        <property type="protein sequence ID" value="KVH97065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUH4"/>
    <dbReference type="STRING" id="59895.A0A103XUH4"/>
    <dbReference type="Gramene" id="KVH97065">
        <property type="protein sequence ID" value="KVH97065"/>
        <property type="gene ID" value="Ccrd_000839"/>
    </dbReference>
    <dbReference type="OMA" id="QHCQVRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF23">
        <property type="entry name" value="DNA-DAMAGE-REPAIR_TOLERATION PROTEIN DRT100-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="118"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="41466" checksum="4D2C53DC0BEAEE1A" modified="2016-04-13" version="1">MVTVSLKTSIAKLEFGERGRERMEATYLVVMMTLLAGVVISCPPSDRGALLAFKSALTDPYLGIFNTWTGSDCCTGWYGISCDPTEGRVNDIILRGESEHTLFAVAGRTGFMSGSLSPSLCSLDRLTTLIVADWKGISGEIPACITSLPRLRILDLVGNQITGEIPVDIGNLGKLTVLNVADNNITGNIPQSIVSLGNLMHLDLRNNRISGEIPANLGKLSMMSRILLKQNELTGSIPTSITSIYRLADLDLSMNQISGSIPAQLGSMPVLSTLNLDSNQLSGEIPGCLLRSNGLNIMNLSHNALEGYLPDVFSSTTYFSMLDLSFNELKGSIPASLAFARYIGHLDLSNNHLCGEIPVGFPFDHLEASSFSDNDCLCGAPLMRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWC3</accession>
    <name>A0A103XWC3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein SCD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWC3"/>
    <dbReference type="STRING" id="59895.A0A103XWC3"/>
    <dbReference type="Gramene" id="KVH98102">
        <property type="protein sequence ID" value="KVH98102"/>
        <property type="gene ID" value="Ccrd_023672"/>
    </dbReference>
    <dbReference type="OMA" id="GPKHEHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040321">
        <property type="entry name" value="SCD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN SCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762">
        <property type="entry name" value="FAS-BINDING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59821" checksum="D88A73715DA4E29B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWM5</accession>
    <name>A0A103XWM5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase A1</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003804">
        <property type="protein sequence ID" value="KVH98273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH98273">
        <property type="protein sequence ID" value="KVH98273"/>
        <property type="gene ID" value="Ccrd_023506"/>
    </dbReference>
    <dbReference type="OMA" id="PSEWCED"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000065">
        <property type="entry name" value="Phospholipase A1-II 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033556">
        <property type="entry name" value="PLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828:SF31">
        <property type="entry name" value="PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48401" checksum="33F217CAB6BF7EE5" modified="2016-04-13" version="1">MASKTYEELHGSNNWDGLLDPLNPDLRTLILGYGDLASAAERALNNNEGSKYAGYSHYGKSSFFKGVMLPWAESKYNVTSFIYATAHVDFPLAFIXRDKSRENSEFESNWMGYVAVSNDEFSKSIGRREICVVWRGTVRTYEWINDILYAGPVPADPLLPSANGKSITSLIGAAIDQPKVMEGWLVIYNTSNPNSPLVKTSARTQLLARVRELLVKYKDEKKSITCVGHSLGASLATVSAFDLAANVATPDIKVSAFVFASPQVGNQAFKNKMEELPNLNVLSIKDINDIVPKWPSKIMEWIDENTILXIPXDVLLYVDVGIDILIDSKKSPFLKEKDGSDILHAFDFHNLEGMLHTVAGYDGKDREFNWQSAEERSLPLVNMSADLLKEEYQIPQSWWVEKNKGMVLNESGDWVLSPVDPDDNDLSPTTTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXA3</accession>
    <name>A0A103XXA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative helicase MAGATAMA 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003789">
        <property type="protein sequence ID" value="KVH98564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XXA3"/>
    <dbReference type="Gramene" id="KVH98564">
        <property type="protein sequence ID" value="KVH98564"/>
        <property type="gene ID" value="Ccrd_023209"/>
    </dbReference>
    <dbReference type="OMA" id="MPRQLKG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF521">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="666"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1259"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1358" mass="151640" checksum="ABD527E73DB2798E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY59</accession>
    <name>A0A103XY59_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH98970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY59"/>
    <dbReference type="STRING" id="59895.A0A103XY59"/>
    <dbReference type="Gramene" id="KVH98970">
        <property type="protein sequence ID" value="KVH98970"/>
        <property type="gene ID" value="Ccrd_022796"/>
    </dbReference>
    <dbReference type="OMA" id="MNILSFE"/>
    <dbReference type="OrthoDB" id="414546at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000009">
        <property type="entry name" value="programmed cell death protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="122"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="286"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="421"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="584"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="714" mass="79105" checksum="18DD469385FE3AF6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYP5</accession>
    <name>A0A103XYP5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003607">
        <property type="protein sequence ID" value="KVH99353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYP5"/>
    <dbReference type="STRING" id="59895.A0A103XYP5"/>
    <dbReference type="Gramene" id="KVH99353">
        <property type="protein sequence ID" value="KVH99353"/>
        <property type="gene ID" value="Ccrd_022416"/>
    </dbReference>
    <dbReference type="OMA" id="IDTFWKT"/>
    <dbReference type="OrthoDB" id="1858881at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33872">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33872:SF2">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="146" mass="16650" checksum="2ADA8A83B3068EF2" modified="2016-04-13" version="1">MGSLMAGWDSPSKSVKLDRNTSMTKVEIASYWRSKKNEEEVHGVLKSSHTFSKGNQKNETEKMYGRSNSLPITKENPVAEIEEEDEEGNREKLFKNGWWMNSRWAFLNEPPVIASETPSRYASQFHVAKKHIDNSNHHVAANGIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ14</accession>
    <name>A0A103XZ14_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003505">
        <property type="protein sequence ID" value="KVH99479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XZ14"/>
    <dbReference type="Gramene" id="KVH99479">
        <property type="protein sequence ID" value="KVH99479"/>
        <property type="gene ID" value="Ccrd_022287"/>
    </dbReference>
    <dbReference type="OMA" id="EHKRINT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="18086" checksum="F4D7D2AF9AE09E61" modified="2016-04-13" version="1">MTKFRKLNRPTGHRMSMLRTMVSQLVKHERIETTVAKAKEVRRLADNMVQLGKEGTLFAARRAAAFVRGDDVIHKLFTELAYRYKAGGYTRVLRTRIRVGDAAPMAYIEFIDRENELRQSKPPAPQPAERPPLDPWTRSQLSRSXAPPKQVKTSEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ32</accession>
    <name>A0A103XZ32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003455">
        <property type="protein sequence ID" value="KVH99529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ32"/>
    <dbReference type="STRING" id="59895.A0A103XZ32"/>
    <dbReference type="Gramene" id="KVH99529">
        <property type="protein sequence ID" value="KVH99529"/>
        <property type="gene ID" value="Ccrd_022236"/>
    </dbReference>
    <dbReference type="OMA" id="PAQMQFI"/>
    <dbReference type="OrthoDB" id="663856at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051758">
        <property type="entry name" value="ERF/AP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657:SF71">
        <property type="entry name" value="DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH99529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="36573" checksum="56D28ECEA34F9945" modified="2016-04-13" version="1">MASAAMDFWNGSGFQQSTAGGELMEALEPFIKSASPPPLPLPPPSNYQNTLLLSTPSTSFPYPSSSSCFLPPSPSSSSYISTIHSQPGFYPDYSIQDQFGYEQPASSFGLTQLTESQMYPMQTQMDLPTQWPQNSNLNFLAPEPVPVKQSGSPPKPTKLYRGVRQRHWGKWVAEIRLPKSRTRLWLGTFDSAEEAALAYDKAAYKLRGDYARLNFPQLRHNGSHISDFKPLHSSVVAKLQTICQCLAEGKSIDGAKKSTSRRSSSAAAAKQATVSQQEVVKVEGFESEGYAGSGNSSPSSDLTFPEFTADDGWCGSEAFSLEKYPSYEIDWGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZW5</accession>
    <name>A0A103XZW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003404">
        <property type="protein sequence ID" value="KVH99943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZW5"/>
    <dbReference type="STRING" id="59895.A0A103XZW5"/>
    <dbReference type="Gramene" id="KVH99943">
        <property type="protein sequence ID" value="KVH99943"/>
        <property type="gene ID" value="Ccrd_021820"/>
    </dbReference>
    <dbReference type="OMA" id="FHIECVS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15539">
        <property type="entry name" value="PHD1_AIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47025">
        <property type="entry name" value="AUTOIMMUNE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47025:SF27">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="535"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="858" mass="95752" checksum="9D8A28CEC36985EC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y126</accession>
    <name>A0A103Y126_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003375">
        <property type="protein sequence ID" value="KVI00563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y126"/>
    <dbReference type="STRING" id="59895.A0A103Y126"/>
    <dbReference type="Gramene" id="KVI00563">
        <property type="protein sequence ID" value="KVI00563"/>
        <property type="gene ID" value="Ccrd_021191"/>
    </dbReference>
    <dbReference type="OMA" id="HRDLCDE"/>
    <dbReference type="OrthoDB" id="688025at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35486:SF3">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35486">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="38252" checksum="B4727EA7DC20F928" modified="2016-04-13" version="1">MRCKKHYTDLSSIVGVCASCLREHLLSLIAAQEQAQSQAQAHAQAQNLDQKHRNLEKNLVFPRSVSPYINYRKSDHSAGAAAWSHNNRRKDHHPHPPTAPRHHHSLSDQLFYRTPQVGPRPTTGCHNTGGHSHHKRSFMRWLSFPKIFRSRNRNSVDTVSVPGASDSTFREQRGGGNATSSPSWFSNIIHGGRYRKKRPVYVDESSVPTAGGVVRRLHCPDRGMSPVRNSDGTVGDEDELYDATSGYESTESMKQTPRRTPAHLPVRRGGGGGHARTLSGLTFCLSPMVRASPNRQWNQKSMPVDGGLSGEIRAPVKPHLSNTKSFCANRSRKLADFGRPNPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1H7</accession>
    <name>A0A103Y1H7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01003242">
        <property type="protein sequence ID" value="KVI00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1H7"/>
    <dbReference type="Gramene" id="KVI00809">
        <property type="protein sequence ID" value="KVI00809"/>
        <property type="gene ID" value="Ccrd_020937"/>
    </dbReference>
    <dbReference type="OMA" id="PIKTEWH"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000030">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF362">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989427" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="56005" checksum="795507EFA6BAC655" modified="2016-04-13" version="1">MANKTLLVLFLFLSACSFIHGNKQLHSLVRFYKAKMSKDGTVNTTSHFEPVQHLHNSATLIDHGAQKENDKIKKLPGQPYVKFDQYGGYVTINESAGRAFYYYFVEAENPKKSSSLPLLLWLNGGPGCSSLAYGAMQELGPFRVNSDGKTLYRNKFSWNRAANVLFLESPAGVGFSYSNTSSDYKNGGDKSTAADNYVFLLNWLERFPEYKGRDLYLSGESYAGHYVPQLAHTIIYHNIIANKTLINLKGILIGNAVINDETDTMGMYDYFGSHALISDETSYDIRKYCNFSADALTQPDKCIDATTDADYNIEVLDIYNIYAPLCFDGNLTIKPKKMSWQNIDPCSDYYTYAYMNRRDVQDALHANVTKLDHDWEPCSEILKGWHDSAATVIPLLKEFMKYKLRVWIFSGDTDARVPVTSTKYSISSMKLPIKTKWHPWIHQGEAGGFVQVYKGDLTLATVRGAGHQVPSYQPKRALALVKHFLSGKPLKDSSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3C9</accession>
    <name>A0A103Y3C9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002686">
        <property type="protein sequence ID" value="KVI01750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3C9"/>
    <dbReference type="STRING" id="59895.A0A103Y3C9"/>
    <dbReference type="Gramene" id="KVI01750">
        <property type="protein sequence ID" value="KVI01750"/>
        <property type="gene ID" value="Ccrd_019971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Neurobeachin alpha-solenoid region" evidence="2">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="25143" checksum="FF06A88A30107C44" modified="2016-04-13" version="1" fragment="single">IKGLVWSFIAGLSPDYDTSTTIFSSGNNSGKYDLSGMAVLSMGLTNGCGSLVLTGMVVTKSGSESTTWIQFAYTYNKERLTAEIIELITAILDENLPNPQQMLNLSGFSVLGFLLQSVGYQQLNMDTLSAMFLIQQFDNDPRLLESLCCFPRDNMPECSLLLDTLELFACNPEVDTGLAKCLLHSLQLAPEKTVSSYRTLDAIPRVLKVSCIQAQEFKKSNSPGTMHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4J9</accession>
    <name>A0A103Y4J9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002653">
        <property type="protein sequence ID" value="KVI02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4J9"/>
    <dbReference type="STRING" id="59895.A0A103Y4J9"/>
    <dbReference type="Gramene" id="KVI02397">
        <property type="protein sequence ID" value="KVI02397"/>
        <property type="gene ID" value="Ccrd_019308"/>
    </dbReference>
    <dbReference type="OMA" id="PNAMCIG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900055">
        <property type="term" value="P:regulation of leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07325">
        <property type="entry name" value="M48_Ste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000007">
        <property type="entry name" value="Peptidase M48 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="332" mass="36213" checksum="F8AE9A7C980C0E43" modified="2016-04-13" version="1" fragment="single">THRLTAVEETHHHSSEPDSHQSTIVINLISNFRFFISLMAVPSSNLTAKSSPLCFGFHVAGNKPFLPSSYAKFGSLKKNRDGGIQITVCKAASPSSSSLSFRYLDADDFRHPLDKQNTLLLRAIPGLNEIGKALLGSIAEQVLVLENIGTSVLVSENQLSELHQLMVQSAEALKIEAPDLYVRQSPSPNAYTLAINGKKPFVVVHTSLIELLSRKELQAVLAHELGHLKCDHGVWLTVANFLTLGANTIPGVGGMIAQRLEEQLFRWLRAAELTCDRAALLVVQDPKVVISVLMKLAGGCPSLADQLNVDAFLEQARSYDKASASPVGWYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4P1</accession>
    <name>A0A103Y4P1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4P1"/>
    <dbReference type="STRING" id="59895.A0A103Y4P1"/>
    <dbReference type="Gramene" id="KVI02455">
        <property type="protein sequence ID" value="KVI02455"/>
        <property type="gene ID" value="Ccrd_019142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558:SF16">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (DUF1336)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="440" mass="49445" checksum="77021900127BB8B2" modified="2016-04-13" version="1">MGSCASTQHKTVHEKKPRHIRSRRFSKSRKKRSDKGSCVAVSEIVQTTTCTQSNDTNSTVQVTQVEWHQMTGQEESWFDPTSKLEDSDSDDYGSVDGVPRDGFPFASDGEVIQYETSSCIVDNEGKYQESYLKIDGCKTESMLCKDGLGGHELSLLRSKGDPLEMRKMLDCHHGSLNGINNRTSVDGEEANEFQSSNKFFYHPRAGLLIPCCTDEKPTPGCWSAIDPSCFTLRGETFFQDKKKSPAPSYCPYTPFGVDLFVCPRKVNHIAQHIELPSLKGDGNLPPLLIVNIQLPTYPASMFHGDGDGEGLSLVLYFKLSETYEEDISPQFQGLIKSFVDDEMEIVKGIRKDTVVPFRERLKIMVGVVNPDDLVSNNTQKKLLHAYNEKPVLSRPQHEFYQAQKPEELPETVLCCLRLNKIDFVNHGQIPTIMVNSKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y572</accession>
    <name>A0A103Y572_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_018971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002641">
        <property type="protein sequence ID" value="KVI02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y572"/>
    <dbReference type="STRING" id="59895.A0A103Y572"/>
    <dbReference type="Gramene" id="KVI02738">
        <property type="protein sequence ID" value="KVI02738"/>
        <property type="gene ID" value="Ccrd_018971"/>
    </dbReference>
    <dbReference type="OMA" id="PPYLCYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000388">
        <property type="entry name" value="Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF35">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE HSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="539"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI02738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="829" mass="91051" checksum="2B47D494D39AD407" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6G5</accession>
    <name>A0A103Y6G5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_018295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002355">
        <property type="protein sequence ID" value="KVI03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6G5"/>
    <dbReference type="STRING" id="59895.A0A103Y6G5"/>
    <dbReference type="Gramene" id="KVI03404">
        <property type="protein sequence ID" value="KVI03404"/>
        <property type="gene ID" value="Ccrd_018295"/>
    </dbReference>
    <dbReference type="OMA" id="LVESADX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000033">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="34335" checksum="48F8A2EA747E1505" modified="2016-04-13" version="1" fragment="single">MREILHVQGGQCGNQIGSKFWEVVCEEHGIDPTGKYIGSSDVQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDGVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFKTLKLTNPSWLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEYGYEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6U4</accession>
    <name>A0A103Y6U4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002339">
        <property type="protein sequence ID" value="KVI03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6U4"/>
    <dbReference type="STRING" id="59895.A0A103Y6U4"/>
    <dbReference type="Gramene" id="KVI03594">
        <property type="protein sequence ID" value="KVI03594"/>
        <property type="gene ID" value="Ccrd_018115"/>
    </dbReference>
    <dbReference type="OMA" id="KIMTQHY"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="38221" checksum="325F520F31952FF2" modified="2016-04-13" version="1">MTDPPSVDAKENKFLKGTFAVVGIMSTLVIYGVLQEKIMRVPYGPNHEFFKHSLFLVFCNRITTSAVSAVFLLTSKKALDPVAPIYKYGVVSISNILTTTCQYEALKYVSFPVQTLAKCAKMIPVMIWGTLIMQKKYKGPDYLLALLVTLGCSLFILFPGATELTPYRNGRESTVWGVSLMIGYLGFDGFTSTFQDKLFKGYDMGIYNQIFYTTLCSCILSLTGLILQGNLLMAIDFVSRHKDCFFDIALLSTVATASQFFISYTIRTFGALTFATIMTTRQLVSILLSCVWFGHPLSVEQFIGAVIVFGSLYARGFLKSKPEKPLPSIHKSDEEVIVPLKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6Y4</accession>
    <name>A0A103Y6Y4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6Y4"/>
    <dbReference type="STRING" id="59895.A0A103Y6Y4"/>
    <dbReference type="Gramene" id="KVI03671">
        <property type="protein sequence ID" value="KVI03671"/>
        <property type="gene ID" value="Ccrd_018045"/>
    </dbReference>
    <dbReference type="OMA" id="IESAERC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="319" mass="37618" checksum="D399B258711D219A" modified="2016-04-13" version="1">MSYSRRSRYSPSSPPHKRYGRSVTRSRSRSRSWSYDSSDIENPGNNLYVTEDVHLVVDPWTRESRGFGFVTMSNIKEADRCIKYLDGSVLEGRVISVEKARRRRGRTPTPGKYLGPKKDHVRGRSSSRDRSRSYSPYCSSRHRRSFSPYDSCGRSYSRSSSPYSRSPVGRHDRLYTREDRSYRSRYYRDYSPDYRRDRSYTPEDGLYRRSRMDYSPGYRRSYRSRSRYYSRDYSPDDRRYYRSRRYRSVSRSISSSPRGRYRGHSPSVSPVGSRRRSSIRVSPRTRSSRRRSYSPVSSRSYSRSVSVGSRTPSSSSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA17</accession>
    <name>A0A103YA17_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="3 15">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_016360</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="15">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="3 15"/>
    <dbReference type="EMBL" id="LEKV01001880">
        <property type="protein sequence ID" value="KVI05285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA17"/>
    <dbReference type="STRING" id="59895.A0A103YA17"/>
    <dbReference type="Gramene" id="KVI05285">
        <property type="protein sequence ID" value="KVI05285"/>
        <property type="gene ID" value="Ccrd_016360"/>
    </dbReference>
    <dbReference type="OMA" id="CYQRKNE"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.50:FF:000001">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000002">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF33">
        <property type="entry name" value="ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12 15" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 15" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042320335" description="S-adenosylmethionine decarboxylase beta chain" evidence="20">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042320333" description="S-adenosylmethionine decarboxylase alpha chain" evidence="20">
        <location>
            <begin position="71"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="16">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="16">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="19">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="18">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVI05285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="39451" checksum="612D7F5A19AD1FDA" modified="2016-04-13" version="1">MAQAVSAIGFEGYEKRLEITFVEPSIFADPEGQGLRALSKAQLDEILNPAECTIVSSLSNDQVDSYVLSESSLFVFPYKIVIKTCGTTKLLLSIPPIMKLADSISLTVRSVRYTRGSFIFPGAQSYPHRSFSEEVSVLDGHFEKLGLSSKAYVMGGFDKPQKWFIYSASAGPVSSGDPVYTLEMCMTSLDREKASVFYKTQWSSAGTMTNDSGIRKILPDSDICDFEFEPCGYSMNAIEDGAISTIHVTPEDGFSYASFEAVGYDLKAVSLEKMVERVLACFEPGEFSIAVGAAVASKSLEKTCWIDVDGYSVEETCGEELGGEGSIIYQKFVKKDGSCCGSPRSVLKSGSWKEKENEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAM5</accession>
    <name>A0A103YAM5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAM5"/>
    <dbReference type="Gramene" id="KVI05575">
        <property type="protein sequence ID" value="KVI05575"/>
        <property type="gene ID" value="Ccrd_016079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="15060" checksum="24E89A82B53E07B1" modified="2016-04-13" version="1">MGIHKTVRRAIMGFGFWTKRPSWNTMGFGSLSFDTAFTSGFPQNHISSQKLLQKSLHHNPRVRSEHTPLPTSREHPPRFRMEITRVKFRQHCSTHRLNVGNLHPSIGGKNKNLNSSRLRYKIIQQSSQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBC9</accession>
    <name>A0A103YBC9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBC9"/>
    <dbReference type="STRING" id="59895.A0A103YBC9"/>
    <dbReference type="Gramene" id="KVI05978">
        <property type="protein sequence ID" value="KVI05978"/>
        <property type="gene ID" value="Ccrd_015656"/>
    </dbReference>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47886" checksum="C3F5ABD57EF87BAC" modified="2016-04-13" version="1">MDEESPTTTPLLHHRRQWWRQIPSNATSSLCLHKTTLWSELGGSVGDLGTYIPIVLALTLVSNLDLGTTLIFTALYNIATGLLFGIPMPVQPMKSIAAVAISESPLLTLSQIAAAGICTASVLLFLGATGLMSFLYRFIPLPVVRGVQLSQGLSFAFTAIKYVRYNQDFAGNKQGGSRSWLGLDGLIVALSSIVFLIITTGSGETYQNRETVAGKRRVRRRLQILSSIPAALIVFLIGIILCFVIDPTIINDLQLGPSKFHVLKITWDDMKTGFLRAAVPQIPLSVLNSVIAVCKLSDDLFPEHEASVTAVSMSVGLMNLVGCWFGAMPVCHGAGGLAGQYRFGGRTGASVVLLGAGKLVLGLLFGNSFVRILNQFPVGILGALLLFAGIELAMASKDMHTKEESFVMLVCAAISLTGSSAALGFVCGIVLFLLLKLREVECGPDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBI3</accession>
    <name>A0A103YBI3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat, cysteine-containing subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBI3"/>
    <dbReference type="STRING" id="59895.A0A103YBI3"/>
    <dbReference type="Gramene" id="KVI06054">
        <property type="protein sequence ID" value="KVI06054"/>
        <property type="gene ID" value="Ccrd_015605"/>
    </dbReference>
    <dbReference type="OMA" id="LSDCMNL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000277">
        <property type="entry name" value="Leucine-rich repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000678">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="46715" checksum="28D2927A030D6115" modified="2016-04-13" version="1">MGPTLPSLSLSAETTNSRSPRFLAPILTPSKVEYLWGELVLENKANRSMKKVDIEVYLEDIPEMEARSGWEPLFIEQLLTVKRERRHVRPSWNCAFMKSVKYKIDQYGSFSMLPRDISQQIFNELVFSQRLIGTYLEAFRDCALQDIDLGEYPEVDDSWMEVILSQGSSLLSADLSGSDITDRALFHIKDCENIQALNFNFCDQISDSGLDSISGLSNLTTLSFKRNNNITAEGMSALSGLVNLLKLDLERCPGIHGGLVHLRGLSKLEALNLNCCNCITDADMEPLSELTNLKELQVSSSKVTDCGVAFLKGLHKLALLNMERCPVTAACLDSLSAIMGLLYLNLSRCKLTGNGCDKFSRLKALKVLNLGFNDVSDAVLVHLNGGSCLINLESLNLDSCRIRDDGLVNLAGGSLLIIYVCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC47</accession>
    <name>A0A103YC47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001833">
        <property type="protein sequence ID" value="KVI06351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC47"/>
    <dbReference type="STRING" id="59895.A0A103YC47"/>
    <dbReference type="Gramene" id="KVI06351">
        <property type="protein sequence ID" value="KVI06351"/>
        <property type="gene ID" value="Ccrd_015303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="26859" checksum="24B72741076FD819" modified="2016-04-13" version="1">MSRGLMNLLRGSKNNWHPPNGVDTTTSSYWLNWRYFLCCLWILISVVMAFYLIMKYERPNNRRTRNGEGGDDDDYGVVVCFEDVWKPCVKAIHPIWLMVFRFGSLWSIYGCYRYHYEVGGGRSEELDEAQAVGPQDRRHPCQAAGFCVYVFQIIFQLPIAMHSTNVVFLLFETALNSLVPIGGIVALSMLWNFLSCNKTEEFSLVEDVLAGWRVRTPVSGRGRKDFSKQPEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCD5</accession>
    <name>A0A103YCD5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCD5"/>
    <dbReference type="STRING" id="59895.A0A103YCD5"/>
    <dbReference type="Gramene" id="KVI06489">
        <property type="protein sequence ID" value="KVI06489"/>
        <property type="gene ID" value="Ccrd_015174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="23637" checksum="674636CD4806B94F" modified="2016-04-13" version="1">MGITPNFAWCNRNNLMTELKLAFSFCGSQASSNLHVPLGTIVSRQFVNSGKLTLPQGVSSISSQRIKQFCGCTIDPNKSSIRERLMALSFQPKTRLLYIIYAYLGLLVVGPNNKLGTKLVGGFKIARGLDVDLLTGNIVSPMLGSLSSAQKTPVQPVYKMENLFINHTNGSKKKEAGAKQLATDYQLARSEEAIANLAQVSAIYRKGDQALRLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCQ4</accession>
    <name>A0A103YCQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001765">
        <property type="protein sequence ID" value="KVI06684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCQ4"/>
    <dbReference type="Gramene" id="KVI06684">
        <property type="protein sequence ID" value="KVI06684"/>
        <property type="gene ID" value="Ccrd_014961"/>
    </dbReference>
    <dbReference type="OMA" id="VTCYGNR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119592" evidence="9">
        <location>
            <begin position="20"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="370"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="639" mass="70468" checksum="0ACBFB69E802648E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDJ3</accession>
    <name>A0A103YDJ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanobacterial aminoacyl-tRNA synthetase CAAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001520">
        <property type="protein sequence ID" value="KVI07114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDJ3"/>
    <dbReference type="STRING" id="59895.A0A103YDJ3"/>
    <dbReference type="Gramene" id="KVI07114">
        <property type="protein sequence ID" value="KVI07114"/>
        <property type="gene ID" value="Ccrd_014529"/>
    </dbReference>
    <dbReference type="OMA" id="ENKPMAV"/>
    <dbReference type="OrthoDB" id="2014299at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025564">
        <property type="entry name" value="CAAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033344">
        <property type="entry name" value="CURT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222:SF35">
        <property type="entry name" value="CYANOBACTERIAL AMINOACYL-TRNA SYNTHETASE, CAAD DOMAIN, PROTEIN CURVATURE THYLAKOID 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14159">
        <property type="entry name" value="CAAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanobacterial aminoacyl-tRNA synthetase CAAD" evidence="3">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="18281" checksum="482662A4FBD0513D" modified="2016-04-13" version="1">MATAAAGTSSSMAQAMFASRSFTPSFSRRSSLPRLPFLPPSASSPLPPSFNLRISGSKKSLSYRIKASSEDSSETSEVGEVFSNLKEKWDALENKPMAVVYGGGAAVGVWLSSTVVNAINSVPVVPKFMELIGLGYTGWFIYRYLLFKSGRKELADDIEVLKKKIIGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFI8</accession>
    <name>A0A103YFI8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GYF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001225">
        <property type="protein sequence ID" value="KVI08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFI8"/>
    <dbReference type="STRING" id="59895.A0A103YFI8"/>
    <dbReference type="Gramene" id="KVI08167">
        <property type="protein sequence ID" value="KVI08167"/>
        <property type="gene ID" value="Ccrd_013466"/>
    </dbReference>
    <dbReference type="OMA" id="HYVENQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045894">
        <property type="entry name" value="At5g08430-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851:SF11">
        <property type="entry name" value="GYF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851">
        <property type="entry name" value="OS01G0884500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="549" mass="62440" checksum="1B6AF33362A9B867" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFS0</accession>
    <name>A0A103YFS0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001146">
        <property type="protein sequence ID" value="KVI08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFS0"/>
    <dbReference type="STRING" id="59895.A0A103YFS0"/>
    <dbReference type="Gramene" id="KVI08292">
        <property type="protein sequence ID" value="KVI08292"/>
        <property type="gene ID" value="Ccrd_013337"/>
    </dbReference>
    <dbReference type="OMA" id="GPQIKGR"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="34550" checksum="1E5110F241A36061" modified="2016-04-13" version="1">MNSVYYKEQDDGSSSNPMGSVPWWSGFVTRSSLEESIPLKPSSMENQTTYGRQPSDHDADQVFEKRDITQFNMFTGDCKNPSNWQKGHVDLGFGQPAVICGEYPYGDRCYGVFSTYGPQIKGRMLLPLNLSNDDEPIFVNAKQYHGIIRRRRSRAKAEMAKKVLKNRKPYLHLSRHLHAMRRPRGNGGRFLNTKKKDDCKDEIMDLKRGENVSGSPNCTVLLLDDSNLTSPCEPNGNRSHVSRSEVTSAFSIGDLKHFQIGNLSVVSLSDMMISGNTKHGFSMHGKRVSMASGGSHYNAKWGSNVLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFW3</accession>
    <name>A0A103YFW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_013274</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001136">
        <property type="protein sequence ID" value="KVI08352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFW3"/>
    <dbReference type="STRING" id="59895.A0A103YFW3"/>
    <dbReference type="Gramene" id="KVI08352">
        <property type="protein sequence ID" value="KVI08352"/>
        <property type="gene ID" value="Ccrd_013274"/>
    </dbReference>
    <dbReference type="OMA" id="SYKYIMN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000226">
        <property type="entry name" value="receptor protein kinase TMK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000190">
        <property type="entry name" value="Receptor-like kinase TMK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052422">
        <property type="entry name" value="Auxin_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47986">
        <property type="entry name" value="OSJNBA0070M12.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47986:SF10">
        <property type="entry name" value="RECEPTOR-LIKE KINASE TMK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119684" evidence="19">
        <location>
            <begin position="27"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="575"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI08352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="915" mass="99693" checksum="13F52D002ED57640" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG79</accession>
    <name>A0A103YG79_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001111">
        <property type="protein sequence ID" value="KVI08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG79"/>
    <dbReference type="Gramene" id="KVI08498">
        <property type="protein sequence ID" value="KVI08498"/>
        <property type="gene ID" value="Ccrd_013116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15853" checksum="005F3DF9519C4F87" modified="2016-04-13" version="1">MEQRRREVLLEYLKSSSVVSLSLSGMFEFGDELIIDSYRIPWLIWIQLLVMFLLVILLYYFSTTPSDLSLHFSTATATATASPSATGLSYHRSLLTSTAANNQHNSKDMEFGEIRAFQMDEKSQLCFTSPQQDIVATDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGZ8</accession>
    <name>A0A103YGZ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGZ8"/>
    <dbReference type="STRING" id="59895.A0A103YGZ8"/>
    <dbReference type="Gramene" id="KVI08931">
        <property type="protein sequence ID" value="KVI08931"/>
        <property type="gene ID" value="Ccrd_012697"/>
    </dbReference>
    <dbReference type="OMA" id="CKWATGI"/>
    <dbReference type="OrthoDB" id="1913536at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="PFYRE" evidence="3">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="402"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="480" mass="54452" checksum="0F6D4EA75CA6B1DA" modified="2016-04-13" version="1">MDTMFTNVTLKHQQFISDHQSFNSTLTSSGSSGSSAHDHHQTTTNHHHHQQCFMEEASSSSLMQQPHFHFHHQFPTSTATATHDVSLEFLASFSTNGWASHVLLEAARAVADKNSCRLNQLIWMLNEISSPYGDIDEKLSSYFLQALFSRITDSGDRNYRILSSISEKMCTFETTRKLVLKFQEVSPWTTFGHVASNGVIMEAFDGETKLHIIDVSNTYCTQWPTLLEAIATRTTEETPHLRLTTVISSTPKSDGSDGIEMIMREIGNRMEKFARLMGVPFKFNVIHHMGDLSDLNFSQLDIQSDEALAINLNGTLRSVSNHRRDYLISMFRSMNPKIVMIVEEEADLDVGIHGIEFLRGFQECLRWFRVYFEALDESFPQTSNERLMLEREAGRAVMNLVACPPANSVERRETADRWSCRLRASGFSGVSYSDEGCDDVRALLRRYKEGWSMGRSETGAGIFLMRKETAVVWASAWKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI22</accession>
    <name>A0A103YI22_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_012124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001059">
        <property type="protein sequence ID" value="KVI09491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI22"/>
    <dbReference type="STRING" id="59895.A0A103YI22"/>
    <dbReference type="Gramene" id="KVI09491">
        <property type="protein sequence ID" value="KVI09491"/>
        <property type="gene ID" value="Ccrd_012124"/>
    </dbReference>
    <dbReference type="OMA" id="KGYMQPQ"/>
    <dbReference type="OrthoDB" id="772609at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31587:SF5">
        <property type="entry name" value="NEMP FAMILY, MFS TRANSPORTER SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31587">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN (DUF2215)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="515" mass="57506" checksum="DF6A44EA5C783008" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YID0</accession>
    <name>A0A103YID0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001049">
        <property type="protein sequence ID" value="KVI09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YID0"/>
    <dbReference type="STRING" id="59895.A0A103YID0"/>
    <dbReference type="Gramene" id="KVI09671">
        <property type="protein sequence ID" value="KVI09671"/>
        <property type="gene ID" value="Ccrd_011949"/>
    </dbReference>
    <dbReference type="OMA" id="RMCSPRI"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019203">
        <property type="term" value="F:carbohydrate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005983">
        <property type="term" value="P:starch catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14526">
        <property type="entry name" value="DSP_laforin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000992">
        <property type="entry name" value="Phosphoglucan phosphatase DSP4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000069">
        <property type="entry name" value="Phosphoglucan phosphatase DSP4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045204">
        <property type="entry name" value="DSP_laforin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052832">
        <property type="entry name" value="Starch-Glucan_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46642:SF7">
        <property type="entry name" value="AMP-ACTIVATED KINASE, GLYCOGEN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46642">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE, SUBGROUP, CATALYTIC DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="92"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="42090" checksum="5FCD6C3FB444307A" modified="2016-04-13" version="1">MNCLANLSRSFSPLPLLSFNCRSSIYPSSVNMKGLMNATDLQGSFLVKATSSSTPSTNMEGTKDEEKSDIYSTNMTEAMGAVLTYRHEIGMNYDFVRPDLIVGSCLQTPADVDKLWSIGVKTIYCLQQDSDLEYFSVDIGAIREYASTFDDIQHLRAEIRDFDGSDLRLRLPAVVSKLHKAINRNGGVTYIHCTAGIGRAPATALAYMFWVQGYKLNDALSLLLRKRKCSPNVDAIKSATADILTGLKKRSITFTWNGDNCSMVEISGLDMGWDQKIPLKYDEKHGSWILHRDLLEGRYEYKYIVDGEWMTNKYEPVTPVNKDGHINNCILVVDNDPESISAALWTRLGSDDFDLTTNEREIIKQFLDMYPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIM1</accession>
    <name>A0A103YIM1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_011854</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIM1"/>
    <dbReference type="STRING" id="59895.A0A103YIM1"/>
    <dbReference type="Gramene" id="KVI09774">
        <property type="protein sequence ID" value="KVI09774"/>
        <property type="gene ID" value="Ccrd_011854"/>
    </dbReference>
    <dbReference type="OMA" id="TFRVQRC"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000008">
        <property type="entry name" value="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF55">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="37038" checksum="37A1FF4C47063784" modified="2016-04-13" version="1">MPLNLLKLTSSISVHHHHHHHHRHKWLRRAITTGKSRPLPATCLGWCRVTEFAPQVYVINNNDNNRLGFRGPTSIRFYSLNKGGKAFGGGNASMESVSSDNRDEKSTPESEHDSSVMPALPSHDRRHQRPPPSHQNSSTKLLTLPTILTIARVAAVPLLISTFYMNSWLGTTATTSIFIAAAITDWLDGYLARRMNLGTAFGAFLDPVADKLMVAATLVLLCTRPPEAAMFGQLPWLLTVPSIAIIGREITMSAVREWAASQGSKLSEAVAVNNLGKWKTATQMSSLTILLVIRDSSFREVGFAWAAAGVGLLYVSGGLAVWSLVVYMKKIWKVMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJL3</accession>
    <name>A0A103YJL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001024">
        <property type="protein sequence ID" value="KVI10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJL3"/>
    <dbReference type="STRING" id="59895.A0A103YJL3"/>
    <dbReference type="Gramene" id="KVI10272">
        <property type="protein sequence ID" value="KVI10272"/>
        <property type="gene ID" value="Ccrd_011316"/>
    </dbReference>
    <dbReference type="OMA" id="GKQKNDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000908">
        <property type="entry name" value="p-loop containing nucleoside triphosphate hydrolase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058874">
        <property type="entry name" value="WHD_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472">
        <property type="entry name" value="DNA REPAIR PROTEIN RADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472:SF12">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25895">
        <property type="entry name" value="WHD_plant_disease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="959" mass="107100" checksum="67FD620E1004BE45" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK12</accession>
    <name>A0A103YK12_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_011031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001012">
        <property type="protein sequence ID" value="KVI10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK12"/>
    <dbReference type="STRING" id="59895.A0A103YK12"/>
    <dbReference type="Gramene" id="KVI10564">
        <property type="protein sequence ID" value="KVI10564"/>
        <property type="gene ID" value="Ccrd_011031"/>
    </dbReference>
    <dbReference type="OMA" id="RRMPVLW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.480:FF:000001">
        <property type="entry name" value="Bystin (51.6 kD)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="541" mass="62335" checksum="68A898E96B61A29B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKA1</accession>
    <name>A0A103YKA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_010967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001008">
        <property type="protein sequence ID" value="KVI10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKA1"/>
    <dbReference type="STRING" id="59895.A0A103YKA1"/>
    <dbReference type="Gramene" id="KVI10632">
        <property type="protein sequence ID" value="KVI10632"/>
        <property type="gene ID" value="Ccrd_010967"/>
    </dbReference>
    <dbReference type="OMA" id="PAELLYY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000002">
        <property type="entry name" value="Magnesium/cobalt efflux protein CorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777:SF31">
        <property type="entry name" value="GLIDING MOTILITY-ASSOCIATED PROTEIN GLDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777">
        <property type="entry name" value="HEMOLYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="138"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="417"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="659" mass="73749" checksum="3AE128B3E855998A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKW6</accession>
    <name>A0A103YKW6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000954">
        <property type="protein sequence ID" value="KVI11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKW6"/>
    <dbReference type="STRING" id="59895.A0A103YKW6"/>
    <dbReference type="Gramene" id="KVI11021">
        <property type="protein sequence ID" value="KVI11021"/>
        <property type="gene ID" value="Ccrd_010573"/>
    </dbReference>
    <dbReference type="OMA" id="HQQLHPC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177">
        <property type="entry name" value="F18C1.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177:SF3">
        <property type="entry name" value="F18C1.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="527"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="816" mass="92959" checksum="63DAAA5BE2F3FD09" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL67</accession>
    <name>A0A103YL67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000894">
        <property type="protein sequence ID" value="KVI11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL67"/>
    <dbReference type="Gramene" id="KVI11127">
        <property type="protein sequence ID" value="KVI11127"/>
        <property type="gene ID" value="Ccrd_010467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16618" checksum="4FB3EAAAFDBD7922" modified="2016-04-13" version="1" fragment="single">MDGGCKDMTSTSTSSHDILLVFMGTKDWNLQASSTQKQAGVPPVALIIFLLGSLLAQRFRSLPDQSLSLPMECSSLLPERESQSFQQLLVLFRHPSFRPLQSLSSPYVYRPSSPQDSWFRNREPSLQSLGFLILLLQPSSLVQFPFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMC0</accession>
    <name>A0A103YMC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hly-III-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000045">
        <property type="protein sequence ID" value="KVI11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMC0"/>
    <dbReference type="STRING" id="59895.A0A103YMC0"/>
    <dbReference type="Gramene" id="KVI11751">
        <property type="protein sequence ID" value="KVI11751"/>
        <property type="gene ID" value="Ccrd_009841"/>
    </dbReference>
    <dbReference type="OMA" id="HSQPCPD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF100">
        <property type="entry name" value="HEPTAHELICAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="40658" checksum="0CD3DA31A7FC75E9" modified="2016-04-13" version="1" fragment="single">MKRRGGKDKGGVVNRFISSESRNMMLKGRSGKRLMKFDELPEYLKDNEFILDYYRCEWPLKDVIGSVFMWHNETLNIWTHLVGFFIFLSLTVLSSLSKEKVESLIASFYSTHGFQEPTMTSAMTKANGSVASMLVPESLVGEILRPSIVLINNPIPKWPWFVFLGGAMGCLICSSISHLFACHSERFNLFFWRLDYAGISLMIVSSFFAPIFYAFTCHPFSRLFYLSSITTLGLLAIFTLLSPALSAPRYRSFRATLFLAMGFSGVIPASHAVFLHWEDSKILVALGYEVMMAAFYSLGAMFYVRRIPEKWKPGAFDIAGHSHQIFHVFVVAGALAHAAATLVIMNLRQTLPAQCIEGATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNE0</accession>
    <name>A0A103YNE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Electron transport accessory protein-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_009252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000007">
        <property type="protein sequence ID" value="KVI12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNE0"/>
    <dbReference type="STRING" id="59895.A0A103YNE0"/>
    <dbReference type="Gramene" id="KVI12319">
        <property type="protein sequence ID" value="KVI12319"/>
        <property type="gene ID" value="Ccrd_009252"/>
    </dbReference>
    <dbReference type="OMA" id="MASWSMA"/>
    <dbReference type="OrthoDB" id="2161449at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.50:FF:000001">
        <property type="entry name" value="Photosystem I reaction center subunit IV, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003375">
        <property type="entry name" value="PSI_PsaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34549:SF3">
        <property type="entry name" value="PHOTOSYSTEM I PSAE, REACTION CENTRE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34549">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT IV A, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02427">
        <property type="entry name" value="PSI_PsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="Electron transport accessory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="14962" checksum="1CC8F8251CA3D66E" modified="2016-04-13" version="1">MASCSMASAASRFMVTPNVTTSNTTTIKPNMVVLLPSQNTRASRLVVRAAEDAAPPPAAGEPTTSTIAEKPKPPPIGPKRGTKVRILRKESYWFKGVGSVVTVDQDPKTRYPVVVRFNKVNYANVSTNNYALDEIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNJ7</accession>
    <name>A0A103YNJ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000003">
        <property type="protein sequence ID" value="KVI12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNJ7"/>
    <dbReference type="STRING" id="59895.A0A103YNJ7"/>
    <dbReference type="Gramene" id="KVI12395">
        <property type="protein sequence ID" value="KVI12395"/>
        <property type="gene ID" value="Ccrd_009162"/>
    </dbReference>
    <dbReference type="OMA" id="CLLEYSR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045849">
        <property type="entry name" value="IP5P_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666:SF22">
        <property type="entry name" value="TYPE I INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="108" mass="12719" checksum="4AD5CDC442CD01D1" modified="2016-04-13" version="1">MLKLCLLEYSRIIWLGDLNYRIALSARSAKALVEARNWRALCDRILWYGRGLHQMCYVRGESRFSDHRPVYSIFIAEVESVSRCKIKKNASCSSRIEVEELLPYVNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118HE81</accession>
    <name>A0A118HE81_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008140">
        <property type="protein sequence ID" value="KVG44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118HE81"/>
    <dbReference type="Gramene" id="KVG44806">
        <property type="protein sequence ID" value="KVG44806"/>
        <property type="gene ID" value="Ccrd_026411"/>
    </dbReference>
    <dbReference type="OMA" id="TMAETKI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007750">
        <property type="entry name" value="DUF674"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33103:SF98">
        <property type="entry name" value="DUF674 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33103">
        <property type="entry name" value="OS01G0153900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05056">
        <property type="entry name" value="DUF674"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="798" mass="88016" checksum="6E2626C5EFA6D8AB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT27</accession>
    <name>A0A118JT27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Barwin-related endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT27"/>
    <dbReference type="STRING" id="59895.A0A118JT27"/>
    <dbReference type="Gramene" id="KVH90039">
        <property type="protein sequence ID" value="KVH90039"/>
        <property type="gene ID" value="Ccrd_007953"/>
    </dbReference>
    <dbReference type="OMA" id="CISCIGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039987">
        <property type="entry name" value="PGRL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31032">
        <property type="entry name" value="PGR5-LIKE PROTEIN 1B, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31032:SF1">
        <property type="entry name" value="PGR5-LIKE PROTEIN 1B, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="425" mass="47383" checksum="D805228CCA5F6E0C" modified="2016-04-13" version="1" fragment="single">MASKLCFTVTNSRFFTAPLPRPSVSLSVSSTLSSSSRVQSNKLIGRDVLSRRRLVIISPRATTDQPGQVKDDVVDSNIMPYCSIEKQQKKSLGEMEQDFLQALQSFYYEGKAIMSNEEFDNLKEELMWEGSSVVMLSSDEQKFLEAAMAYVSGNPIMTDAEYDKLKMQLKKDGSDIVVEGPRCSLRTRKVYSDLSVDYLKMFLINVPAAVVAVGLFFFLDDITGFEITYLLEACVLPEPFSFIFTWFAALPFILWLSFSFTSLIVKDFLILKGICPNCGTENNSFFGTILSISSGGTTNNAKCTKCISCIGCLSAEHLDPGPRHVVWGRVCRFSHGQKLVTNGYGTNTAALVRRSLAMDMRVGSVIRFVVSNLHGVPMVWPRSQRQTSAHPTDPRTLNNGGWCNPPRTHLNMAKPAFMQIARWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTW3</accession>
    <name>A0A118JTW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTW3"/>
    <dbReference type="Gramene" id="KVH90010">
        <property type="protein sequence ID" value="KVH90010"/>
        <property type="gene ID" value="Ccrd_007930"/>
    </dbReference>
    <dbReference type="OMA" id="NNMSVTF"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015145">
        <property type="term" value="F:monosaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17361">
        <property type="entry name" value="MFS_STP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000002">
        <property type="entry name" value="Sugar transport protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044778">
        <property type="entry name" value="MFS_STP/MST-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF601">
        <property type="entry name" value="MAJOR FACILITATOR, SUGAR TRANSPORTER, MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="525" mass="58059" checksum="DB265403C11B53DE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU44</accession>
    <name>A0A118JU44_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU44"/>
    <dbReference type="Gramene" id="KVH90952">
        <property type="protein sequence ID" value="KVH90952"/>
        <property type="gene ID" value="Ccrd_007044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="32731" checksum="2AA24B5CF7F0C99F" modified="2016-04-13" version="1" fragment="single">MESLRLAKERNSGLPKAIYGNLVLRTVNASNLDPATKPRVPMAHLLPEIVEQILIRLKVRDLIRCKSVSKSWHSLISDPRFIKAHLKHSYESDRNNEEIGDRRIVMSKYACFYTYQQFEVDGKLFDFHDCHLLGSSDGLEKFAEVPQPDDVSYWSRVSDHPSMRLGTINGCLCSFQYENLPNDLWMMKNYNVKQSWGIFGPERVIKYEAVHGIKRLKNYIPNQRPLCHEPWLVRSRETEEKEAGRGYHKECSALYAVPRAQPSTDEGTSSGSSTRAEASGNAGPSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUK9</accession>
    <name>A0A118JUK9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CYCLOPS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005044">
        <property type="protein sequence ID" value="KVH91347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUK9"/>
    <dbReference type="STRING" id="59895.A0A118JUK9"/>
    <dbReference type="Gramene" id="KVH91347">
        <property type="protein sequence ID" value="KVH91347"/>
        <property type="gene ID" value="Ccrd_006630"/>
    </dbReference>
    <dbReference type="OMA" id="TSEDMFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036377">
        <property type="term" value="P:arbuscular mycorrhizal association"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040036">
        <property type="entry name" value="CYCLOPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36890">
        <property type="entry name" value="PROTEIN CYCLOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36890:SF1">
        <property type="entry name" value="PROTEIN CYCLOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50959" checksum="3A8E35D0BA77FDBD" modified="2016-04-13" version="1">MEMEGRVYSDLYRNTSEDMFIRTMMESSVGIPAPTMEMLGFKNLSSNFRADSEELFKSWLTTGENQGHNSTGLVHNRPRQLSRMLTDQANGDLHPTKRSSENLTPQSTLAVGESSCGMNEHSVRNLAEKGLQDSNLFLAKEDSSSSTFSAPKVGPIDKVSSVVSMLKGTLERKKLGNHVDKEAIEDSSFGYHGGQEVFAYSHMNQVREIHMHEAQGGTFQDLTTAGIKDPEYADLACFMAPTNLIQMNIASQEPSQSESSAAAPVISTGFDVSDGPSNSDIRERVYGNLKEDQKNKGNLSRHGSVTSAASGAERGDPTKKRRVERSRKYVPSSLHLSEASHLAYRFSFSITFSNKKFPYAKDLTPLVSISGLPRMAEAKERTQTPTTSSDMQSILKRCENLEKEVRSLKLNLAFMNRKDSEQTKQIEELQKQNEDMGDEKERLLEEIERILSQQDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUN6</accession>
    <name>A0A118JUN6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VDE lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004946">
        <property type="protein sequence ID" value="KVH91482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUN6"/>
    <dbReference type="STRING" id="59895.A0A118JUN6"/>
    <dbReference type="Gramene" id="KVH91482">
        <property type="protein sequence ID" value="KVH91482"/>
        <property type="gene ID" value="Ccrd_006495"/>
    </dbReference>
    <dbReference type="OMA" id="FTVDNCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010028">
        <property type="term" value="P:xanthophyll cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044682">
        <property type="entry name" value="VDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010788">
        <property type="entry name" value="VDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970:SF2">
        <property type="entry name" value="OS01G0716400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07137">
        <property type="entry name" value="VDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VDE lipocalin" evidence="1">
        <location>
            <begin position="238"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="513" mass="58084" checksum="B890918B09A8F0C1" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVQ8</accession>
    <name>A0A118JVQ8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004794">
        <property type="protein sequence ID" value="KVH93147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVQ8"/>
    <dbReference type="STRING" id="59895.A0A118JVQ8"/>
    <dbReference type="Gramene" id="KVH93147">
        <property type="protein sequence ID" value="KVH93147"/>
        <property type="gene ID" value="Ccrd_004832"/>
    </dbReference>
    <dbReference type="OMA" id="TSRAHEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="275" mass="31669" checksum="E1CD720CAC605AF4" modified="2016-04-13" version="1">MSVEEKFRIVRSIGEECIQEEELLNLLTKKPQPICYDGFEPSGRMHIAQGVMKTINVNKLTSAGCKVKIWIADWFAQLNNKMGGDLNKIQTVGRYLIEIWKAAGMNLEGDKVEFLWSSEEINSRAHEYWPLVMDIARRNKLPRIMRLADICQLGMDQRKVNVLAREYCDDIKRKNKPIILSHHMLPGLLQGQEKMSKSDSSSAVFMEDEEAEVNLKIKKAYCPPNIVDGNPCLEYIKYIVFPWFNEFKIERKEENGGENAVGTVFYFSVLKVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXA6</accession>
    <name>A0A118JXA6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyphenol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_001104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="8">Binds 2 copper ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004179">
        <property type="protein sequence ID" value="KVH96804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXA6"/>
    <dbReference type="STRING" id="59895.A0A118JXA6"/>
    <dbReference type="Gramene" id="KVH96804">
        <property type="protein sequence ID" value="KVH96804"/>
        <property type="gene ID" value="Ccrd_001104"/>
    </dbReference>
    <dbReference type="OMA" id="QANFENM"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000007">
        <property type="entry name" value="Polyphenol oxidase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016213">
        <property type="entry name" value="Polyphenol_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022740">
        <property type="entry name" value="Polyphenol_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022739">
        <property type="entry name" value="Polyphenol_oxidase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12142">
        <property type="entry name" value="PPO1_DWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12143">
        <property type="entry name" value="PPO1_KFDV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000290">
        <property type="entry name" value="PPO_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="117"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="cross-link" description="2'-(S-cysteinyl)-histidine (Cys-His)" evidence="10">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000290-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH96804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="593" mass="66177" checksum="D1E6A5385AE8AA86" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYQ6</accession>
    <name>A0A118JYQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003808">
        <property type="protein sequence ID" value="KVH98152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYQ6"/>
    <dbReference type="STRING" id="59895.A0A118JYQ6"/>
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        <property type="protein sequence ID" value="KVH98152"/>
        <property type="gene ID" value="Ccrd_023626"/>
    </dbReference>
    <dbReference type="OMA" id="AYCTDAF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF13">
        <property type="entry name" value="ADENINE_GUANINE PERMEASE AZG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="554" mass="59497" checksum="EF98A5F5DBBC7E02" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ55</accession>
    <name>A0A118JZ55_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RINT-1/TIP-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003455">
        <property type="protein sequence ID" value="KVH99536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ55"/>
    <dbReference type="STRING" id="59895.A0A118JZ55"/>
    <dbReference type="Gramene" id="KVH99536">
        <property type="protein sequence ID" value="KVH99536"/>
        <property type="gene ID" value="Ccrd_022233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF1">
        <property type="entry name" value="RINT1-LIKE PROTEIN MAG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="28561" checksum="0D9E0DA3918E0BC5" modified="2016-04-13" version="1">MDELLQPLVDEAMLSGYSCRGEWISVMAEIELSDSIDKLRPEIEDEKKRLMEVQESALVLGSEDYRSPAISSAFLRRVSFMIECCWSLPGVPLRAKFIRMAVASIMHRFLDFLLFRCQEAEGLTALTDDDALIKVTSRDYMKNRKQWLEKREEGWAVSKSFIGAIGYLQAKMSIIEVNLNKMDFVGDCRNLATDIDCLVFSGIFMSNTKLSDAGVERFTNDLTILFGVFKAWCLRPEGFIEMRMRWIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZM4</accession>
    <name>A0A118JZM4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZM4"/>
    <dbReference type="Gramene" id="KVI00120">
        <property type="protein sequence ID" value="KVI00120"/>
        <property type="gene ID" value="Ccrd_021616"/>
    </dbReference>
    <dbReference type="OMA" id="LQIHSHC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20401">
        <property type="entry name" value="Tudor_AtPTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056618">
        <property type="entry name" value="Chromo_PTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047365">
        <property type="entry name" value="Tudor_AtPTM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508">
        <property type="entry name" value="PHD FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508:SF1">
        <property type="entry name" value="PHD FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24294">
        <property type="entry name" value="Chromo_PTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21743">
        <property type="entry name" value="PTM_DIR17_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="9">
        <location>
            <begin position="231"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="1705"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1548"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1316"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1607"/>
            <end position="1620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1758" mass="195095" checksum="ED95405585842828" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZT9</accession>
    <name>A0A118JZT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">At4g14310 8-bladed propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZT9"/>
    <dbReference type="STRING" id="59895.A0A118JZT9"/>
    <dbReference type="Gramene" id="KVI00345">
        <property type="protein sequence ID" value="KVI00345"/>
        <property type="gene ID" value="Ccrd_021337"/>
    </dbReference>
    <dbReference type="OMA" id="YYDIANC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045289">
        <property type="entry name" value="At4g14310-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057442">
        <property type="entry name" value="Beta-prop_At4g14310"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35492">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35492:SF1">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25465">
        <property type="entry name" value="Beta-prop_At4g14310"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At4g14310 8-bladed propeller" evidence="2">
        <location>
            <begin position="672"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="At4g14310 8-bladed propeller" evidence="2">
        <location>
            <begin position="761"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="934" mass="101852" checksum="2E25F7C9B7895CAF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K087</accession>
    <name>A0A118K087_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K087"/>
    <dbReference type="STRING" id="59895.A0A118K087"/>
    <dbReference type="Gramene" id="KVI00136">
        <property type="protein sequence ID" value="KVI00136"/>
        <property type="gene ID" value="Ccrd_021588"/>
    </dbReference>
    <dbReference type="OMA" id="CINQFEG"/>
    <dbReference type="OrthoDB" id="773760at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044594">
        <property type="entry name" value="HIPP01/3/5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413:SF38">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED DOMAIN, HMA, HEAVY METAL-ASSOCIATED DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="329" mass="35156" checksum="A9FF1D3B69F1B9CF" modified="2016-04-13" version="1">MAKKKNQNNNNENEDENQNENENGDEGCGGGKKQKATATGVTVVVFKMDLHCEGCAGRVVKAIRALDGVESVRIGDSELSKITVIGNLDPVKLRQKVEEKTNKKVELISPTAKKNNDGDNTIQSGGGGDNKKQQRQPPSLEKPAKTAVKKDEKKPKEIPVTTAVLKVPLHCQGCVRRIHKLVTKTKGYMEMSIDKNKDLVMVKGAIDMKLLVEALQHKLRRAVEIVPQKKDGGAGDDGGEKKGKGGGGEKKGKDNDGEGKGGEKKGKGGGGGGEGNDGGGKTTEVLKMENHGAPTVFPYPQYAYGSGYADYVHAPQLFSDENPHACSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K145</accession>
    <name>A0A118K145_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GrpE nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002659">
        <property type="protein sequence ID" value="KVI02295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K145"/>
    <dbReference type="STRING" id="59895.A0A118K145"/>
    <dbReference type="Gramene" id="KVI02295">
        <property type="protein sequence ID" value="KVI02295"/>
        <property type="gene ID" value="Ccrd_019416"/>
    </dbReference>
    <dbReference type="OMA" id="THCMIEL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF43">
        <property type="entry name" value="GRPE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="26014" checksum="91A7331998E45814" modified="2016-04-13" version="1">MVVGRITTRIARAVVTRCHSSLILRGRPINRPSIPISGNHFCSLPGSQNKVIAGQISLLHNSILSSSAFQRFGISSSASPQANEKSTSENGGPTTNKPDDAKENAKENDNGQGSGEEDLTVEDLVKLVTEKEELLKTKQEEIEKMKDKNFAKSLLDVADNLDRASSVVKESFAKIDTSEDSAGAVPLLKTLLEGVEMTEKQLAEFSKYQIPPSLLTLLQLCSRQDTHCMIELYALLKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2K5</accession>
    <name>A0A118K2K5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002030">
        <property type="protein sequence ID" value="KVI04498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2K5"/>
    <dbReference type="STRING" id="59895.A0A118K2K5"/>
    <dbReference type="Gramene" id="KVI04498">
        <property type="protein sequence ID" value="KVI04498"/>
        <property type="gene ID" value="Ccrd_017186"/>
    </dbReference>
    <dbReference type="OMA" id="GKHQNNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="29536" checksum="8460DEC0D72AD922" modified="2016-04-13" version="1" fragment="single">MEALVCRKLGDPTTPPDSSEDSSLTVSTSHPIPKLDSPTSVRVRIKSTSLNYANYLQVLGKYQEKFALPFVPGSDFSGIVESVGPDVTNFKIGDPVCSFAGVGSFAQFIVAEEKDLFGVPDGCDLVAAGALPVAYGTSHVALVHRANLKSGQVLLVLGAAGGVGLAAVQIGKVCGATVIAVARGAEKVEFLKSMGVDHVVDLSKGGVIESVKAFLRTRKLKGVDVLYDPVGGKLTKESMKLLSWGAQILVIGFASGEVPELLSWLAKGLITIYISQSYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2P1</accession>
    <name>A0A118K2P1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase Rpb1, domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001939">
        <property type="protein sequence ID" value="KVI04680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2P1"/>
    <dbReference type="STRING" id="59895.A0A118K2P1"/>
    <dbReference type="Gramene" id="KVI04680">
        <property type="protein sequence ID" value="KVI04680"/>
        <property type="gene ID" value="Ccrd_016998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="181" mass="21430" checksum="A3AC07660A8EF073" modified="2016-04-13" version="1">MEVWALEGCLLINVIILELARKYLVIESLEKQTDSWGCSRIFSVACSRTTIFSSELNHFPVSEKTFQINNLRFCEQCGVEFVDSRIRRYQMGNIKLACPVMHVWYLKRLPSYIVNLLDKSLKELEDLVYCNPNFFYYPELRYISKSRDVYRAMNGKIEKLEEEKIFCLGTWNWLSVLLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3D6</accession>
    <name>A0A118K3D6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)</fullName>
            <ecNumber evidence="3">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3D6"/>
    <dbReference type="STRING" id="59895.A0A118K3D6"/>
    <dbReference type="Gramene" id="KVI05748">
        <property type="protein sequence ID" value="KVI05748"/>
        <property type="gene ID" value="Ccrd_015939"/>
    </dbReference>
    <dbReference type="OMA" id="FIDSEYM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF112">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPC1, CYTOSOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="314" mass="34343" checksum="848DCD82F64B914C" modified="2016-04-13" version="1">MGSDKKIKIGINGFGRIGRLVARVALQRDDVELVAVNDPFISTDYMVLSSVCVFVLITMQVLMFTSDSTYMFKYDSVHGQWKHNELKIKDEKTLLFGEAPVAVFGFRNPEEIPWGSVGADFVVESTGVFTDKDKAAAHLKVINDRFGIVEGLMTTVHSITATQKTVDGPSSKDWRGGRAASFNIIPSSTGAAKAVGKVLPVLNGKLTGMSFRVPTVDVSVVDLTVRLEKKATYEQIKAAIKEESEGKLKGILGYIEEDVVSTDFIGDSRSSIFDAKAGIALNDNFVKLVSWYDNEWGYSSRVVDLICHIASVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3X5</accession>
    <name>A0A118K3X5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001773">
        <property type="protein sequence ID" value="KVI06645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3X5"/>
    <dbReference type="Gramene" id="KVI06645">
        <property type="protein sequence ID" value="KVI06645"/>
        <property type="gene ID" value="Ccrd_015002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="31544" checksum="7B6974C11DDE4BE7" modified="2016-04-13" version="1">MGFKGLLNMKTDGIPAKLGYYVFDLFDPQNMLIKLENGVIPITISKTTWKPGPIECYYSGPLTTLKLLYVDTIQCDSVHIICERPCIASWSMDILRRREAIEIFTGGFGIGNAVKPLVDAQCEDSSRENEESDIKRYLDGIEHIFNRLKTLKSDFDEILKKARTSYPASVEFEGWQKNLIDLVVDDNMDCDASMNMPLAKSGGTKQASTSDSWQGVMEGAQDIVETPTQFFSHVEIIKRVEKAIKVYEKLQMLDFSLGLTQELGEVADAKENDPNRKCCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4B4</accession>
    <name>A0A118K4B4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4B4"/>
    <dbReference type="STRING" id="59895.A0A118K4B4"/>
    <dbReference type="Gramene" id="KVI07291">
        <property type="protein sequence ID" value="KVI07291"/>
        <property type="gene ID" value="Ccrd_014313"/>
    </dbReference>
    <dbReference type="OMA" id="QHQHMIR"/>
    <dbReference type="OrthoDB" id="2016447at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF83">
        <property type="entry name" value="PROTEIN ASYMMETRIC LEAVES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="6">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="25163" checksum="219BA3FCA40A6D31" modified="2016-04-13" version="1">MASSSTSPCAACKFLRRKCQPECVFAPYFPPDQPQKFANVHKVFGASNVTKLLNELHPHQREDAVNSLAYEADMRLRDPVYGCVGVISLLQHQLRQLQMDLSYAKSELSKYQSHNLNGSATQGLIAAAAAAAAATHHHHHHQTLGNNLIGCCGGGVVSRDHLYHHHSPFFPTRDQQTAAIRAFDVNSSYDGTTGGGAGVLAMNASTGCIGQHPQFQQPRAAGNDDRPTPIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4P9</accession>
    <name>A0A118K4P9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="LEKV01001483">
        <property type="protein sequence ID" value="KVI07845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4P9"/>
    <dbReference type="STRING" id="59895.A0A118K4P9"/>
    <dbReference type="Gramene" id="KVI07845">
        <property type="protein sequence ID" value="KVI07845"/>
        <property type="gene ID" value="Ccrd_013807"/>
    </dbReference>
    <dbReference type="OMA" id="KNIMQNC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF22">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="46427" checksum="2BEC4EDC5B2F5196" modified="2016-04-13" version="1">MPDQPIPKDAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIARLFHAPIGEDDTAVGVGTVGSSEAIMLAEVKVKEGYYVMDPVKAVELVDENTICVAAILGSTMTGEFEDVKLLNELLTKKNEETGWNVPIHVDAASGGFVAPFLYPDLEWDFRLPLVKSINVSGHKYGLVYAGVGWVVWRTKDDLPDELVFHINYLGSDQPTFTLNFSKGSSQIIAQYYQFIRLGFEGYRDVMKNCNGNVTVLKEGLEKTGRFNIISKDVGIPLLAFSLKDSSRYTVFDISESLRRFGWIVPAYTMPPDAQHILVLRVVIREDFSHSLADRLIADIVKVVNEMEDAQSIASMSHAHDGTPSDRSTREMQRGITKYWRRFVHGKKTSSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4S2</accession>
    <name>A0A118K4S2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001448">
        <property type="protein sequence ID" value="KVI07965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000004">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="35969" checksum="7CF4D7981E1D617E" modified="2016-04-13" version="1" fragment="single">IHSTRFTIKNNCPFGIAPATLTGTGDSVTTGFELAPQASNTITMPVPWSGRVWARFQCSNNGGRFQCNSGDCGSGQVGCNGAGAAPPATLVEFTLSPAGQNDFYDVSLVDGFNLPVSVVPQGGIHSTRFTIRNNCPYRIAPATLTGTGNSVSTGFELAPQASNTITMPVPWSGRVWARFQCSNNGGRFRCNSGDCGSGQVGCNGAGAAPPATLVEFTLSPAGQNDFYDVSLVDGFNLPVSVVPQGGAXCPTTDCPVDINAQCPQELAVXDASGGTIGCKSACLQFNXPEYCCTGNNNXPETCPPTDYSRFFKNLCPKAYSYAYDDTSSTFTCGNGADYLITFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K528</accession>
    <name>A0A118K528_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">O-acyltransferase, WSD1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_013166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001118">
        <property type="protein sequence ID" value="KVI08462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K528"/>
    <dbReference type="STRING" id="59895.A0A118K528"/>
    <dbReference type="Gramene" id="KVI08462">
        <property type="protein sequence ID" value="KVI08462"/>
        <property type="gene ID" value="Ccrd_013166"/>
    </dbReference>
    <dbReference type="OMA" id="WEVHIVN"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF34">
        <property type="entry name" value="O-ACYLTRANSFERASE WSD1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="11">
        <location>
            <begin position="67"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="12">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="456" mass="51080" checksum="C6E3B84B8B3F1FAB" modified="2016-04-13" version="1">MIFPCVEEILLKEEDLNLWVEDENGGKHWKQVEVKVEDHMIAPRFPDGLSLESYDVYIGDYLSGLGMDPFPKAKPLWEIHVIKYPTSKSSGSLIFKLHHALGDGYTIMGVMLSCLQRADNPSIPLTFPSFRKPPKPDNGMKSILSLVPQVLSGVVNTVLDFGMSILQSSLLEDSSTPIRSAEEGVEFLPTVVTTMTFSLDQIKQIKDILEVTINDIVSGVIFLGTRLYMEATSNESGNARSTSLVLLNTRSIGGYRSVDEMLHNPEAQNLWGNQFAFLQVSLPKLRQAHNSLDPLKFVYEAHNIIKRKRNSSAVYLTGMLLESIRKYRGTEAAAKYVHLTQKNASMGLTNLAGPIEKMSLCNQPIKGLYFMIFNVPQVSSFPNTNQSALYAYSIIDPMPILVDATFWQSYKVTVMSYMNQLRVTLGTQKGFIDPMKLKRCIEEAYDMILKAALNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5C7</accession>
    <name>A0A118K5C7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metallophosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_012734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001080">
        <property type="protein sequence ID" value="KVI08897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5C7"/>
    <dbReference type="Gramene" id="KVI08897">
        <property type="protein sequence ID" value="KVI08897"/>
        <property type="gene ID" value="Ccrd_012734"/>
    </dbReference>
    <dbReference type="OMA" id="HIVPMEY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000038">
        <property type="entry name" value="Probable inactive purple acid phosphatase 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011230">
        <property type="entry name" value="PAP14/16/28/29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030250">
        <property type="entry name" value="Ptase_At2g46880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159984" evidence="11">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI08897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="42340" checksum="0F347E70B445C3B5" modified="2016-04-13" version="1">MARFLLAILVVFCSLSSFTLVNTERIQRLSNGGGSKQLRFGRKKGEFKILQVADMHYADGRKTPCEDVLPKQFSHCSDLNTSVFINRMIQAEKPDFIVFTGDNIFGFDATDAVASMNAAFAPAIASKTPWAAVLGNHDQESTLSREGVMKHIVGMKHTLSQLNPLGVDVIDGFGNYNLEVHGVEGSSSMNKSILNLYFLDSGDYSTVPSILGYGWIKPSQQFWFQQTSKKLRKKSKAPGLAYFHIPLPEFANFDSSNFTGVRQEGISSASVNSGFFTTLVEAGDVKGVFSGHDHLNDFCGKLSGIHLCYGGGFGYHAYGKAGWSRRARVVMVSLEKKSHGDWGAVKSIKTWKRLDDKHLTAIDDQVLWSRHPSGSRRKKPVGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124PVN4</accession>
    <name>A0A124PVN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009969">
        <property type="protein sequence ID" value="KVE95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WNLHACE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVE95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="14" mass="1618" checksum="8328EBE3FB7143B1" modified="2016-04-13" version="1">MNELLSTDGQDFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBD3</accession>
    <name>A0A124SBD3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005108">
        <property type="protein sequence ID" value="KVH90297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBD3"/>
    <dbReference type="STRING" id="59895.A0A124SBD3"/>
    <dbReference type="Gramene" id="KVH90297">
        <property type="protein sequence ID" value="KVH90297"/>
        <property type="gene ID" value="Ccrd_007706"/>
    </dbReference>
    <dbReference type="OMA" id="VAVNFYC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="592" mass="63884" checksum="D7CDB9E93EAB0ED5" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBL6</accession>
    <name>A0A124SBL6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBL6"/>
    <dbReference type="STRING" id="59895.A0A124SBL6"/>
    <dbReference type="Gramene" id="KVH91030">
        <property type="protein sequence ID" value="KVH91030"/>
        <property type="gene ID" value="Ccrd_006946"/>
    </dbReference>
    <dbReference type="OMA" id="TRAWHED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44575">
        <property type="entry name" value="OS01G0589200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44575:SF2">
        <property type="entry name" value="OS01G0589200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="339"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="62466" checksum="FD9D4D2DF51FA1AA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBV8</accession>
    <name>A0A124SBV8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBV8"/>
    <dbReference type="STRING" id="59895.A0A124SBV8"/>
    <dbReference type="Gramene" id="KVH91872">
        <property type="protein sequence ID" value="KVH91872"/>
        <property type="gene ID" value="Ccrd_006116"/>
    </dbReference>
    <dbReference type="OMA" id="YDFTHSR"/>
    <dbReference type="OrthoDB" id="1939710at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021916">
        <property type="entry name" value="DUF3527"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31390:SF0">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF3527)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31390">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12043">
        <property type="entry name" value="DUF3527"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="635" mass="70770" checksum="6A9298411955E9F0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD36</accession>
    <name>A0A124SD36_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD36"/>
    <dbReference type="Gramene" id="KVH95707">
        <property type="protein sequence ID" value="KVH95707"/>
        <property type="gene ID" value="Ccrd_002219"/>
    </dbReference>
    <dbReference type="OMA" id="PKHAFQT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF83">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 75-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="6">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="241" mass="27443" checksum="656DF73A1944C96A" modified="2016-04-13" version="1">MTNITAVIVAAPRLFNKSILTYLSRPSLHLISFHLSLSLSQMEINNGGMFSYTSSSTSSPPPAAAINSSSYLSLNMMNNDEYSHVNNYSKQQQQQQQQVVGLMEKDGIQMYESSDDMVADQPTSSRLTDDLNMASGKSSIRKGEKKIRKPKHAFQTRSQVDILDDGYRWRKYGQKAVKNNKFPRNYYRCTYQGCNVKKQVQRLSNDDGVVVTTYEGMHSHPIEKSTDNFEHILTQMQIYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDG9</accession>
    <name>A0A124SDG9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004087">
        <property type="protein sequence ID" value="KVH96912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDG9"/>
    <dbReference type="Gramene" id="KVH96912">
        <property type="protein sequence ID" value="KVH96912"/>
        <property type="gene ID" value="Ccrd_000994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012700964" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="33" mass="3629" checksum="09ADF225C1358C62" modified="2016-04-13" version="1">MWSALAFWIVQSLAGFCDRGGTRPASVDIVMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE41</accession>
    <name>A0A124SE41_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE41"/>
    <dbReference type="STRING" id="59895.A0A124SE41"/>
    <dbReference type="Gramene" id="KVH98892">
        <property type="protein sequence ID" value="KVH98892"/>
        <property type="gene ID" value="Ccrd_022887"/>
    </dbReference>
    <dbReference type="OMA" id="RHPSPWN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36764">
        <property type="entry name" value="TRNA (ILE)-LYSIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36764:SF1">
        <property type="entry name" value="TRNA (ILE)-LYSIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="336" mass="35938" checksum="81BE5A2C222765CC" modified="2016-04-13" version="1">MVAISLYRGKLHRSPDVPRQWLMPTPKISLKDFKTLLHRRSRALSRLQATTTPNPNPNPNLNSVEDNNSGGRVPTESDGPGVEDVAKDEGTSKANGDKRTVDDELARSNYADEEVNGQKLSKGDDEDEVLGIPGDELVAVDDAKAVAEVPENAPDAVDGFQQEGKTDAPPQHLLEPVENNSLSDIEKRKKEVEEKLQILNARKHNLVQVLKQGSTGRPLMPLQVDVGNDNGSMSRHVTPQPVSEGNCNGDTEGADADDGPNQNLRSRSLPRMSSVPNPSRTPSGVAASSPSRFAPSGQQANPTASVTGTNYVPTSPSPAAGGSLAFRDARLPSPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEC1</accession>
    <name>A0A124SEC1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 18 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003439">
        <property type="protein sequence ID" value="KVH99577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEC1"/>
    <dbReference type="STRING" id="59895.A0A124SEC1"/>
    <dbReference type="Gramene" id="KVH99577">
        <property type="protein sequence ID" value="KVH99577"/>
        <property type="gene ID" value="Ccrd_022189"/>
    </dbReference>
    <dbReference type="OMA" id="DLNRATY"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000121">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 18 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH99577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="540" mass="60315" checksum="C1165F966E9C3BC9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEC4</accession>
    <name>A0A124SEC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003419">
        <property type="protein sequence ID" value="KVH99700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEC4"/>
    <dbReference type="STRING" id="59895.A0A124SEC4"/>
    <dbReference type="Gramene" id="KVH99700">
        <property type="protein sequence ID" value="KVH99700"/>
        <property type="gene ID" value="Ccrd_022064"/>
    </dbReference>
    <dbReference type="OMA" id="ASKQMTP"/>
    <dbReference type="OrthoDB" id="665906at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000006">
        <property type="entry name" value="ethylene-responsive transcription factor ERF014-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF231">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="213" mass="23580" checksum="00A91D6172C5B979" modified="2016-04-13" version="1">MAKKGQKFRSQPLKTVLSSPLPSTPSLSKEKYKGVRMRSWGSWVSEIRAPNQKSRIWLGSYSTPEAAARAYDAALLCVRGPIANLNFSQHQYDHTTTTTTTMMSPKSIKRVAALAAATIPSPSPSPPPSPILSSPSYSSQLSTVSPSKSSSYNKEKNQRFYLENDPLDGTLMSMVAPWCNFDSPTYNDMMCNESAYDPSDDEEGGEIRLWSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF25</accession>
    <name>A0A124SF25_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002675">
        <property type="protein sequence ID" value="KVI01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF25"/>
    <dbReference type="STRING" id="59895.A0A124SF25"/>
    <dbReference type="Gramene" id="KVI01873">
        <property type="protein sequence ID" value="KVI01873"/>
        <property type="gene ID" value="Ccrd_019845"/>
    </dbReference>
    <dbReference type="OMA" id="SKTFNMT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009862">
        <property type="term" value="P:systemic acquired resistance, salicylic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000099">
        <property type="entry name" value="LL-diaminopimelate aminotransferase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="94"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="451" mass="48979" checksum="007B5776A01A6CD6" modified="2016-04-13" version="1">MSVLPHHLVATSLSSSTSNFFAQNSFDVVRTQVVSAPFRKMGVCKCVATSPTEQTAYKTQVSRNGNIAKLQAGYLFPEIGRRKAAHMLKHPDAQVISLGIGDTTEPIPEVITSAMAKRALALSTVEGYSGYGAEQGEKQLRARLASTFYGNLGIEEDDIFVSDGAKSDISRLQVCVLFGSNVTMAVQDPSYPAYVDSSVIMGQTGQFQKDVEKFGKIEYMKCTPENDFFPDLSKVSRTDIIFFCSPNNPTGSAASREQLIQLVKFAKDNGSIIIYDSAYAMYVSGDTPKSIFEIPGAKEVAIETASFSKYAGFTGVRLGWTVVPKELKYSDGFPVAKDFNRIVCTGFNGASNIAQAGGLACLSPEGLEIIVDTFTSLGFKVYGGKHAPYVWVHFPGQSSWDVFSEILEKTHVVTTPGSGFGPAGEGFVRVSAFGHRDNVLEACRRFKELYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGD6</accession>
    <name>A0A124SGD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGD6"/>
    <dbReference type="STRING" id="59895.A0A124SGD6"/>
    <dbReference type="Gramene" id="KVI06058">
        <property type="protein sequence ID" value="KVI06058"/>
        <property type="gene ID" value="Ccrd_015609"/>
    </dbReference>
    <dbReference type="OMA" id="HSAREEH"/>
    <dbReference type="OrthoDB" id="1918952at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008889">
        <property type="entry name" value="VQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039611">
        <property type="entry name" value="VQ_4/11/13/19/31/33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33402:SF19">
        <property type="entry name" value="VQ MOTIF-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33402">
        <property type="entry name" value="VQ MOTIF-CONTAINING PROTEIN 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05678">
        <property type="entry name" value="VQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VQ" evidence="4">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="20228" checksum="CDFF0D8834085E9F" modified="2016-04-13" version="1">MASFFNGNNVEVFGPNSKPATTFVQTDPSNFRAVVQRLTGATTLYQPSASAYKLPISTPSHHAGKPTFTEIGRRRSGYKLHERRKTIRKLEISVENVARRPLMSPAARKRSVRADGEMVVASPVSTLDVCGGEGSCPGTPMEEEEEKAIAEKGFYLHPSPKRGSEPKLLVLFPLNSPINDPSYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH20</accession>
    <name>A0A124SH20_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001222">
        <property type="protein sequence ID" value="KVI08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH20"/>
    <dbReference type="STRING" id="59895.A0A124SH20"/>
    <dbReference type="Gramene" id="KVI08173">
        <property type="protein sequence ID" value="KVI08173"/>
        <property type="gene ID" value="Ccrd_013457"/>
    </dbReference>
    <dbReference type="OMA" id="SYEHIGG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="227" mass="25288" checksum="340A1EFC5BFF140E" modified="2016-04-13" version="1" fragment="single">MAEVMNMPVDRRSSGEKKDDDDDNDKKLANDENADASPPATAPAPASAPTPAPAQALAPARPSSQRRDRDSRERRNDDRDRDTERPSNRRSDYYDNRNRSSPVPPHRDYKRHAASPISPPPPLYRDRRGGGHSPPRRSPPFPQFKRSRRDEGSHDGRRGSPRGGFGPGDRRFGYDHPGSYEHIGGRAGYQEDRPRGWYGGRSSGGYQGGPSDWDFTRGGYNDAAVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHD2</accession>
    <name>A0A124SHD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHD2"/>
    <dbReference type="STRING" id="59895.A0A124SHD2"/>
    <dbReference type="Gramene" id="KVI09166">
        <property type="protein sequence ID" value="KVI09166"/>
        <property type="gene ID" value="Ccrd_012433"/>
    </dbReference>
    <dbReference type="OMA" id="AHEIFYM"/>
    <dbReference type="OrthoDB" id="1111059at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012442">
        <property type="entry name" value="DUF1645_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095:SF123">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095">
        <property type="entry name" value="OS07G0619500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07816">
        <property type="entry name" value="DUF1645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="261" mass="29040" checksum="0BD106B17F1536F2" modified="2016-04-13" version="1">MQNQGQVDDLGFCPSFNCYSSDSLASTAATRVSSQLLQEQVARFHDVGEEDFEFSLVLDDEQVSVRDAASEGRVVFPLFNRDLLVKDEGDREAVQGKVDDDQEDACSASLEKLFITEREESASSSSSEADESESEAPGVFCAWRPKMDIGSSPLSKCKKSSSTGSGSKRWRIRDLLRRSNSEGKEPMVLLTPKKVEVPKQKRKSGEVSIVSGKSKPSIHELFYVQQRAKREDGKRKSYLPYRQGLVGFFTNVNGKGNKFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SIC6</accession>
    <name>A0A124SIC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SIC6"/>
    <dbReference type="STRING" id="59895.A0A124SIC6"/>
    <dbReference type="Gramene" id="KVI12268">
        <property type="protein sequence ID" value="KVI12268"/>
        <property type="gene ID" value="Ccrd_009314"/>
    </dbReference>
    <dbReference type="OMA" id="GPHNTAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF21">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL32Y-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="16851" checksum="F46E20A46791436E" modified="2016-04-13" version="1">MAVPKLDKKIVKKRVKKFKRPHSDWKICVKVYFDFTLLQENWRRPKGIDSRVRRKFKGVTLMPNIGYGSDKKTRHYLPNGFKKFVVHNAKELEVLMMHNRTYCAEIAHNVSTRKRKEIVERAAQLDVVVTNKLARLRSQEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103TDI5</accession>
    <name>A0A103TDI5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">fructokinase</fullName>
            <ecNumber evidence="9">2.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_025934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in maintaining the flux of carbon towards starch formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01007137">
        <property type="protein sequence ID" value="KVH14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103TDI5"/>
    <dbReference type="STRING" id="59895.A0A103TDI5"/>
    <dbReference type="Gramene" id="KVH14836">
        <property type="protein sequence ID" value="KVH14836"/>
        <property type="gene ID" value="Ccrd_025934"/>
    </dbReference>
    <dbReference type="OMA" id="DDQHGRF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01167">
        <property type="entry name" value="bac_FRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000005">
        <property type="entry name" value="Probable fructokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050306">
        <property type="entry name" value="PfkB_Carbo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF6">
        <property type="entry name" value="FRUCTOKINASE-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085">
        <property type="entry name" value="HEXOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="6"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="32733" checksum="76E8CE2FA0545F6C" modified="2016-04-13" version="1">MAASSMVVCFGEMLIDFVPDTAGVSLAESQGFIKAPGGAPANVACAIAKLGGSAAFVGKVGKDEFGYMLTDILKKNGVNTDGVLFDEHARTALAFVTLKKDGEREFMFYRNPSADMLLKESELKMDMIKKANIFHYGSISLITEPCRSAHMAAMKAAKQAGVLLSYDPNVRLPLWPSADAARTGIKSIWKEADFIKVSDDEVEFLTQKSADNEDAVKSLWHDGLKLMVVTDGEKGCRYYTKACPSFKGKVPGCKVKAIDTTGAGDAFVGSLLALAFSNACGAICTTKKGAIPALPTTSDAQALLSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X481</accession>
    <name>A0A103X481_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_025466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006398">
        <property type="protein sequence ID" value="KVH83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X481"/>
    <dbReference type="STRING" id="59895.A0A103X481"/>
    <dbReference type="Gramene" id="KVH83866">
        <property type="protein sequence ID" value="KVH83866"/>
        <property type="gene ID" value="Ccrd_025466"/>
    </dbReference>
    <dbReference type="OMA" id="FFRRQMN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009704">
        <property type="term" value="P:de-etiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048564">
        <property type="term" value="P:photosystem I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009472">
        <property type="entry name" value="Tab2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046761">
        <property type="entry name" value="Tab2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046760">
        <property type="entry name" value="Tab2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34556">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34556:SF2">
        <property type="entry name" value="PROTEIN TAB2 HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20429">
        <property type="entry name" value="Tab2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06485">
        <property type="entry name" value="Tab2-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-binding protein Tab2-like N-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding protein Tab2/Atab2 C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="440" mass="48740" checksum="B19BC30436CB2263" modified="2016-04-13" version="1">MDEKDKELITKALGCIKDRLKFRNIDVLIRPGVFVADNQLPFPDELAAQLITRPFSSMTGLGIGIASLSINTTRIRHPNIQFSELTPKPIKIPFHSSLFLTKLPTNEPKTLTLRPSSVSESSVSSSIGAESLDDVDDDPTAELSYLDPETDPESITEWELDFCSRPILDIRGKKIWELVACDSSLSLQYTKYFPNNVINSVTLKDAIVSICDELDVPLPDKVRFFRSQMQTIITKACKELGIKPIPSKRCLSLLLWLGERYETVYTRHPGFQKGSKPLLALDNPFPMDLPDSLYGEKWAFVQLPFSDVKRELLSQEKSFAFGATLDLDLLGIEMDDETLIPGLAVASSRARPLAAWMNGLEVCSVEADLARANLVLSVGISTCYVYASYKKSSVTTSEAEAWEAAKKASGGLHFLAIQDTLDSDNCVGFWLLLDLPPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XAZ6</accession>
    <name>A0A103XAZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006274">
        <property type="protein sequence ID" value="KVH87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XAZ6"/>
    <dbReference type="Gramene" id="KVH87396">
        <property type="protein sequence ID" value="KVH87396"/>
        <property type="gene ID" value="Ccrd_025372"/>
    </dbReference>
    <dbReference type="OMA" id="WMHGAEG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000037">
        <property type="entry name" value="Protein NRT1/ PTR FAMILY 5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="571" mass="63106" checksum="BC44B17522440EED" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB72</accession>
    <name>A0A103XB72_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006131">
        <property type="protein sequence ID" value="KVH87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB72"/>
    <dbReference type="STRING" id="59895.A0A103XB72"/>
    <dbReference type="Gramene" id="KVH87500">
        <property type="protein sequence ID" value="KVH87500"/>
        <property type="gene ID" value="Ccrd_025240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044508">
        <property type="entry name" value="At5g50450/At1g67340-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758">
        <property type="entry name" value="MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758:SF2">
        <property type="entry name" value="OJ1485_B09.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="19206" checksum="E271FC47D1C4D28D" modified="2016-04-13" version="1">MVAGGGDEEEKRGSGGLKNDKDLRAGVALYARAAFLGHADAMRELGQCLQDGYGVRKNVEEGRRLLVQANVRELSSLRLITLDANSLYGFHLSKGMNYLHQNYIVHRDLKAANLLLDEHDAAQDAELPVTSSISPEGMEKTTAPVGTASPSNMQVYAGVAPLMSMADNFAAATASLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCL3</accession>
    <name>A0A103XCL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005487">
        <property type="protein sequence ID" value="KVH88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XCL3"/>
    <dbReference type="Gramene" id="KVH88249">
        <property type="protein sequence ID" value="KVH88249"/>
        <property type="gene ID" value="Ccrd_024329"/>
    </dbReference>
    <dbReference type="OMA" id="VMHDANK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="82" mass="9792" checksum="AF5DB7668E8C7ED1" modified="2016-04-13" version="1">MDVIFAVRSYPPENLVETEKQMKKLKQKKETTTEDLQREEAFFAHVKYNFKVKKQEXVRFMAQSXPYAMQVVTVMHDANKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCW6</accession>
    <name>A0A103XCW6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005410">
        <property type="protein sequence ID" value="KVH88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCW6"/>
    <dbReference type="Gramene" id="KVH88426">
        <property type="protein sequence ID" value="KVH88426"/>
        <property type="gene ID" value="Ccrd_026830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="574" mass="65108" checksum="5EB1748277D606DE" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE94</accession>
    <name>A0A103XE94_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphomannomutase</fullName>
            <ecNumber evidence="3">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005309">
        <property type="protein sequence ID" value="KVH89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE94"/>
    <dbReference type="STRING" id="59895.A0A103XE94"/>
    <dbReference type="Gramene" id="KVH89143">
        <property type="protein sequence ID" value="KVH89143"/>
        <property type="gene ID" value="Ccrd_008893"/>
    </dbReference>
    <dbReference type="OMA" id="SIXGGND"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18893" checksum="B5A0D037CEC7F70F" modified="2016-04-13" version="1">MAVRRPGLIALFDVDGTLTAPRKSLKTHLGDENIRDFINFTLHYLADIDIPIKRGTFIEFRSGMINVHNIRAKMVEVLREKFAHLNLTFSIGGQISFDAFPQGWDKTYCLKYLDEFEEIHFFGDKTYKGGNDHEIYESARTVGHTVTSPDDTMDQCTTLFLNKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFE9</accession>
    <name>A0A103XFE9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005152">
        <property type="protein sequence ID" value="KVH89721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFE9"/>
    <dbReference type="STRING" id="59895.A0A103XFE9"/>
    <dbReference type="Gramene" id="KVH89721">
        <property type="protein sequence ID" value="KVH89721"/>
        <property type="gene ID" value="Ccrd_008284"/>
    </dbReference>
    <dbReference type="OMA" id="MWENHIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030946">
        <property type="term" value="F:protein tyrosine phosphatase activity, metal-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="282" mass="32025" checksum="E9A55E6AD917AEA5" modified="2016-04-13" version="1">MDQKINVFVWDMDETLVLLKSLITGTYAKAFNGSKDVQKGIEIGKTWENQILRICDDHFFYEQIESCNKPYVDAMREYDDGLDLTDYDFANDGFVGASFDDDDNKRKLAYRHRLIAHKYKKGLRSVFGEKMIKSWDNLYEVTDDFTDKWLSSARTCVAECASGTKDVTPLVDSTSSRTQNVNVIVTSGSLIPSLVKCLLFRLDDLISYENERFNGPNVQFCAIGDGWEECEAAENMQWPFVQIDPGPVSTSHRFPGLTVETLGHYIGVVYGESDDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG37</accession>
    <name>A0A103XG37_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG37"/>
    <dbReference type="STRING" id="59895.A0A103XG37"/>
    <dbReference type="Gramene" id="KVH90029">
        <property type="protein sequence ID" value="KVH90029"/>
        <property type="gene ID" value="Ccrd_007968"/>
    </dbReference>
    <dbReference type="OMA" id="GSCMRRS"/>
    <dbReference type="OrthoDB" id="1885101at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040358">
        <property type="entry name" value="At4g22758-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055482">
        <property type="entry name" value="DUF7054"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270">
        <property type="entry name" value="BNAC05G50380D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270:SF6">
        <property type="entry name" value="OS02G0448600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23156">
        <property type="entry name" value="DUF7054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7054" evidence="2">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="28223" checksum="EFFBD73982F83886" modified="2016-04-13" version="1">MSEKRLRGRVPVSRRIRPPHPSPSTHRLRRRVVIVRRSSSKKPLKFINRCNSVPALLTVDVGGATEDPGGLMSISRSRPDIFSSAPELVLPYSPSKIQRDSKELHMHQYNKDAKVVVNVTVEGCPGAIRAMVRLGSTVEETMKIVKHQYESEGRCPRLDQRSISTFELHPSHFSLRCLDKSDKIGNFGSRSFYMRKRSNENSIIGPEIISTRRNGSPSPPPSPTVLFPNFICRNFKKVIRLLGKLLGCLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHJ0</accession>
    <name>A0A103XHJ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005093">
        <property type="protein sequence ID" value="KVH90779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHJ0"/>
    <dbReference type="Gramene" id="KVH90779">
        <property type="protein sequence ID" value="KVH90779"/>
        <property type="gene ID" value="Ccrd_007188"/>
    </dbReference>
    <dbReference type="OMA" id="FSWNVAI"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000690">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000348">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000462">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000576">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF436">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="676" mass="76216" checksum="22EACE2EC6A1F97E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI33</accession>
    <name>A0A103XI33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005074">
        <property type="protein sequence ID" value="KVH91145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI33"/>
    <dbReference type="Gramene" id="KVH91145">
        <property type="protein sequence ID" value="KVH91145"/>
        <property type="gene ID" value="Ccrd_006840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="131" mass="15456" checksum="B50892326973E315" modified="2016-04-13" version="1">MREQKLRSPRSDGRRSRNGGRPSEIEREREGRWLRDRAEREEGRGGGLERSREEGGGGEIDREREREEGAVDERDREKRAVVERSIDRERERGRKGRWSREEGRGGEIERERRKGGADGGESEREKKRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJF5</accession>
    <name>A0A103XJF5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJF5"/>
    <dbReference type="STRING" id="59895.A0A103XJF5"/>
    <dbReference type="Gramene" id="KVH91878">
        <property type="protein sequence ID" value="KVH91878"/>
        <property type="gene ID" value="Ccrd_006095"/>
    </dbReference>
    <dbReference type="OMA" id="SCFRAYL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF11">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="4">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="400" mass="44300" checksum="DED45BA9A80DC97D" modified="2016-04-13" version="1">MGKTSKFFKSLLGFKSTGAQPSGSDGNKQPKRRWSFVKSRRENQNPTQRNNSKSVVGTSFHHNHHNNSDERTEGGERNDSNEDSNKRAIALAAATAAVVDAALVAAQAAAEVVRMTSRTTGYGVHHELAAVKIQSCFRAYLAVVRGHILRKHTADMMRRLQALIRAQARARARALSTKSSSHFHHHGPQTPEKLEHFPHAKQDHRPIHKRNGSKSYANYGLTDHENDKIVEVDTGESHVTTKGRKLFQLDPNQNSFGYSQSFTTSRGSTVQPTSSSPCASCEVNSIDYSIKGELSTPVKSECSRSCLSGYSDHPNYMANTESSRAKVRSLSAPRLRTQFEISNATKRDSSSKYGSGGMQWVPTIRDSFVRKAYPGSGRLDRLGMPVLAMEENEFCVGYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJK0</accession>
    <name>A0A103XJK0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="6">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="6">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004898">
        <property type="protein sequence ID" value="KVH91892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJK0"/>
    <dbReference type="STRING" id="59895.A0A103XJK0"/>
    <dbReference type="Gramene" id="KVH91892">
        <property type="protein sequence ID" value="KVH91892"/>
        <property type="gene ID" value="Ccrd_006048"/>
    </dbReference>
    <dbReference type="OMA" id="MDDMVGG"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04088">
        <property type="entry name" value="EFG_mtEFG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000006">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="75"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="148"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="727" mass="79878" checksum="AE0A9C0FFBC6B81B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK33</accession>
    <name>A0A103XK33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004844">
        <property type="protein sequence ID" value="KVH92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK33"/>
    <dbReference type="STRING" id="59895.A0A103XK33"/>
    <dbReference type="Gramene" id="KVH92138">
        <property type="protein sequence ID" value="KVH92138"/>
        <property type="gene ID" value="Ccrd_005835"/>
    </dbReference>
    <dbReference type="OMA" id="HRAIFIK"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106286">
        <property type="term" value="F:(E)-caffeate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12118">
        <property type="entry name" value="ttLC_FACS_AEE21_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006020">
        <property type="entry name" value="PRK08162.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF26">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE, AMP-BINDING ENZYME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="553" mass="60631" checksum="C172DB61449313F7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKF7</accession>
    <name>A0A103XKF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004821">
        <property type="protein sequence ID" value="KVH92370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKF7"/>
    <dbReference type="Gramene" id="KVH92370">
        <property type="protein sequence ID" value="KVH92370"/>
        <property type="gene ID" value="Ccrd_005612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="12714" checksum="D6B53BA163DCC93B" modified="2016-04-13" version="1">MDLLSTFQICNLLLDSRLEGPYGCLFVVAGAAASAADGGHQVCGFCFLISCLVLVLACGLQGKVVTHDLFICGFSNDPAVTHGFSYDQSDVIPFRCFLNDIRSLIGCSLLPCDTLAADIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKS9</accession>
    <name>A0A103XKS9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004812">
        <property type="protein sequence ID" value="KVH92616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKS9"/>
    <dbReference type="Gramene" id="KVH92616">
        <property type="protein sequence ID" value="KVH92616"/>
        <property type="gene ID" value="Ccrd_005342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="72" mass="8537" checksum="9218C24BE296F2A6" modified="2016-04-13" version="1">MWGSSSPNSRDKRKSPHPQFNPITMVKEKKEMMKRNRELKPIEGGIKWKNKQKRILLIVEEEVLLKTTTTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN56</accession>
    <name>A0A103XN56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004595">
        <property type="protein sequence ID" value="KVH93829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN56"/>
    <dbReference type="Gramene" id="KVH93829">
        <property type="protein sequence ID" value="KVH93829"/>
        <property type="gene ID" value="Ccrd_004116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="12862" checksum="CF8026C144B5F12B" modified="2016-04-13" version="1">MANCISFFHTQIKTTALSFTAPHKEFKMSYAAKTIRRRSFRNHAEGYSHGTNGYYYPPSAKLQGDGDDNDTYYDYAPAASEGDGDDDDADYDYAPAASDGDGHDDDDRDYDYAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNZ7</accession>
    <name>A0A103XNZ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PSII 6.1 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the psbW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNZ7"/>
    <dbReference type="STRING" id="59895.A0A103XNZ7"/>
    <dbReference type="Gramene" id="KVH94336">
        <property type="protein sequence ID" value="KVH94336"/>
        <property type="gene ID" value="Ccrd_003602"/>
    </dbReference>
    <dbReference type="OMA" id="YFIYTAS"/>
    <dbReference type="OrthoDB" id="2017665at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042549">
        <property type="term" value="P:photosystem II stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009806">
        <property type="entry name" value="PSII_PsbW_class2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34552">
        <property type="entry name" value="PHOTOSYSTEM II REACTION CENTER W PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34552:SF12">
        <property type="entry name" value="PHOTOSYSTEM II REACTION CENTER W PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07123">
        <property type="entry name" value="PsbW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="125" mass="13331" checksum="36E09CCA082C8D79" modified="2016-04-13" version="1">MASIFASTITTTLLPKKPSTLLGTTCKMGKVRCSVDRGTSKGISQRLVMTTVSSFVATTMVATMSSPIAMALVDERMSTEGTGLPFGLSNNLLGWILFGVFGLIWTLYFVYTGSLDEDDDSGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP01</accession>
    <name>A0A103XP01_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004573">
        <property type="protein sequence ID" value="KVH94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH94064">
        <property type="protein sequence ID" value="KVH94064"/>
        <property type="gene ID" value="Ccrd_003879"/>
    </dbReference>
    <dbReference type="OMA" id="YFLNMRK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000382">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000343">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g58590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000427">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF441">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="894"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125055" checksum="71C6F34CCC1138DE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR62</accession>
    <name>A0A103XR62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004392">
        <property type="protein sequence ID" value="KVH95358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR62"/>
    <dbReference type="Gramene" id="KVH95358">
        <property type="protein sequence ID" value="KVH95358"/>
        <property type="gene ID" value="Ccrd_002589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="21657" checksum="1948F9B3B238F9EC" modified="2016-04-13" version="1">MASMQLQKPVDHTKNFPQHGHVPTNAQNKCNTCGYQKPVDHNKNNPQNGHALAQNKCNNTCSCCQRKENEHSFTNKVKEMANSAYKKVADQMHHHDQHSNGHRPITGPKQACHGSGGVTEGKKKEGSMTNCIPRIGDHKRREKIPKKKGNNCKCKDGSGSRSRSRSSSSDSESDNDAHMKRSRGGALADTSKKMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSQ2</accession>
    <name>A0A103XSQ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001737</name>
        <name evidence="4" type="ORF">Ccrd_001738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004349">
        <property type="protein sequence ID" value="KVH96182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01004349">
        <property type="protein sequence ID" value="KVH96185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSQ2"/>
    <dbReference type="Gramene" id="KVH96182">
        <property type="protein sequence ID" value="KVH96182"/>
        <property type="gene ID" value="Ccrd_001738"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH96185">
        <property type="protein sequence ID" value="KVH96185"/>
        <property type="gene ID" value="Ccrd_001737"/>
    </dbReference>
    <dbReference type="OMA" id="QTIECND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF92">
        <property type="entry name" value="VINORINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="48240" checksum="788D30D431BE6F5A" modified="2016-04-13" version="1">MIMAKLQRFGRIRQLHTIISQETIKPSSPTPPHLKTHNLSLLDRFVGHIHMPIVFFYPNYDHGDTHILKKSLSQSLTQYYPFAGRFPAPHAPHINCNDEGVVFLEASNNGRLDEFIRKKEHDETMDRLIPNGLGCTMHKTSPNLIEVQLNHFAGGGAALAVSISHKLADALTMASFFNHWATVTRGGSPINPSFVSSSVTNNEILGFPLIDTEKLNYVRRRFVFPNSKLYELKNKVNAMGTSPMNPSRVELLTSLLFKCAVDSATRKSGSLMPSNLFHTVNMRNRNIKKFPETAAGNLSTTVIAKIATDSGEIKLHEVIGTLRKGIMELEELSNVEEVIGNLLSKLSPLEGEQSRAYISSSMCRFPFYEMDFGWGKPVDIMFRIPEVNDSCVLLMDAQSGDGIEALVRLQEEEMDIFRKDKDLLAYVEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTM1</accession>
    <name>A0A103XTM1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004254">
        <property type="protein sequence ID" value="KVH96677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTM1"/>
    <dbReference type="Gramene" id="KVH96677">
        <property type="protein sequence ID" value="KVH96677"/>
        <property type="gene ID" value="Ccrd_001240"/>
    </dbReference>
    <dbReference type="OMA" id="YMVPCGI"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="753" mass="84803" checksum="02DFCD7A5167BEA7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUL6</accession>
    <name>A0A103XUL6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003852">
        <property type="protein sequence ID" value="KVH97169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUL6"/>
    <dbReference type="STRING" id="59895.A0A103XUL6"/>
    <dbReference type="Gramene" id="KVH97169">
        <property type="protein sequence ID" value="KVH97169"/>
        <property type="gene ID" value="Ccrd_000733"/>
    </dbReference>
    <dbReference type="OMA" id="TIACKIK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000359">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="28211" checksum="9752E53FD80A3406" modified="2016-04-13" version="1" fragment="single">LSFPLLFTCSSDSLSIPHRSFNSLPGKHPPHSHLKQFHSFSLGFLRSISPAMTPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLSEIDRFASENVNKLLVGNKCDLVKNKVVSTEVAKAYADEIGIPFMEASAKEATNVEQAFMAMAASIKDRMASQPSMNMSRPPTVNIRGQPVNQSSGCCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW41</accession>
    <name>A0A103XW41_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW41"/>
    <dbReference type="STRING" id="59895.A0A103XW41"/>
    <dbReference type="Gramene" id="KVH97988">
        <property type="protein sequence ID" value="KVH97988"/>
        <property type="gene ID" value="Ccrd_023796"/>
    </dbReference>
    <dbReference type="OMA" id="VRIYGMM"/>
    <dbReference type="OrthoDB" id="675068at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000373">
        <property type="term" value="P:Group II intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044190">
        <property type="entry name" value="THA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594">
        <property type="entry name" value="PPR CONTAINING PLANT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594:SF3">
        <property type="entry name" value="PROTEIN THYLAKOID ASSEMBLY 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25921" checksum="BEB77A0B97B733DE" modified="2016-04-13" version="1">MASSLRLHLPFSSPYHHRSAAIHLAAKSIRHLTIRCGPRDNRGPLHKGRTLSIEAIQAVQSLKRSHRSDPANNDAVSKTLSRLVKSDVVAAFNELIRQDQFDLALKVFSAIRSEDWYKTELSLYAKLVSSMASKGMADDIDRLILDVEPEAVISADSKGLITLIKALIAADRAESTVVIYEMMKAGGWGCNSVTDDYLGKVLSRGLRRLGKKKVADEIDREIGRVSGGILENMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWJ3</accession>
    <name>A0A103XWJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWJ3"/>
    <dbReference type="STRING" id="59895.A0A103XWJ3"/>
    <dbReference type="Gramene" id="KVH98210">
        <property type="protein sequence ID" value="KVH98210"/>
        <property type="gene ID" value="Ccrd_023559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33413">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33413:SF33">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20076" checksum="04FB0A6F07367E84" modified="2016-04-13" version="1">MGNCQAIDNASLVIQHPNGRVERLYSAISAAEVMKLNPGHYVALLLTTTLYSSRPPSTSAPTKQNHPGSVANTTQPLRVTRIKLLRPTDTLTVGHIYRLITTKDVMKGLMAKKNGKININKLKPLEESAGNHEAKVTGSNHSERTHHQMKKSDKDRRRTAVPAKSSAAARGWHPSLNSISEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWN8</accession>
    <name>A0A103XWN8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Double-stranded RNA-binding-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003805">
        <property type="protein sequence ID" value="KVH98248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWN8"/>
    <dbReference type="STRING" id="59895.A0A103XWN8"/>
    <dbReference type="Gramene" id="KVH98248">
        <property type="protein sequence ID" value="KVH98248"/>
        <property type="gene ID" value="Ccrd_023526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF6">
        <property type="entry name" value="CLASS I PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="26597" checksum="FC269DB74E975914" modified="2016-04-13" version="1">MALYLVKSCVKFWPKTTAPSTAAPIRLRRFQIRFPIIRSDNITSFSPNRTSSFHYTTSVDKISPISSSNNDGGREFVAMSDEKLMSQCEMDTYKSSGPGGQHRNKRETAVRLKHLPTGIIAQASEDRSQHKNRASALARLRSLLALKVRNTIELETYTPPPELLQILPAKSTIRGSECGPQIGPNNSNLSTGALSRLILSDDSLRQAVNEFRTSKSHDPGNHGPAGENIYEKNMPKFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWZ8</accession>
    <name>A0A103XWZ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multi antimicrobial extrusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003799">
        <property type="protein sequence ID" value="KVH98404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWZ8"/>
    <dbReference type="STRING" id="59895.A0A103XWZ8"/>
    <dbReference type="Gramene" id="KVH98404">
        <property type="protein sequence ID" value="KVH98404"/>
        <property type="gene ID" value="Ccrd_023377"/>
    </dbReference>
    <dbReference type="OMA" id="LEVWYLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="407" mass="44327" checksum="793DA94D7BCAD5C0" modified="2016-04-13" version="1" fragment="single">MESHADAPLLTSKHVSNNVHFRNDIQDSPPITGAKEFFVQFGIESKKLWYLAGPAIFTSVCRYSLGAVTQTFAGHVGTLDLAAFSVENSVIAGFSLGIMLGMGSALETLCGQAYGAGHVDMLGVYMQRSWVILLVTAMMMLSLYIFATPLLLFIGQTEEIAHAAGKMALWMIPQLFAYALNYPIAKFLQAQSKIMVMAYIAATALVLHTLFSWLLMLKLGWGLLGGAVVLNLSWWFIVVAQLIYIFSGSCGRAWSGFSWAAFSNLWSFVKLSFASAIMLCLETWYFMALVLFAGYLKNAEVAVDALSICVRVSNELGAGHPRAAKFAIGVVVASSFAFGVAIGAGWQAVIAYINIACYYVFGIPLGLTLGFLADWGIKGIWIGMLTGTVVQTTVLFCICYRTNWDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYP4</accession>
    <name>A0A103XYP4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003607">
        <property type="protein sequence ID" value="KVH99347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYP4"/>
    <dbReference type="STRING" id="59895.A0A103XYP4"/>
    <dbReference type="Gramene" id="KVH99347">
        <property type="protein sequence ID" value="KVH99347"/>
        <property type="gene ID" value="Ccrd_022421"/>
    </dbReference>
    <dbReference type="OMA" id="VEMIFRH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF23">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="245" mass="26933" checksum="15C430264DC955F7" modified="2016-04-13" version="1">MSFRDENEEGKDLRKPFLHTGSWYRMGSRQSSMMTSSQMIRDRSVSVLACVLIVALGPIQFGFTGGYSSPTQTDISRDLKLTVSEFSLFGSLSNVGAMVGAIASGQIAEYIGRKGDSSFLYMGRLLEGFGVGIISYTVNLLFSDVCSRKKLSEKTTLMEPSFITKVPVYIAEIAPQNMRGGLGSVNQVTLFRNLSVTIGIMLSYLLGLFVNWRILAILGTLPCLILIPGLFFIPESPRWLVSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYS6</accession>
    <name>A0A103XYS6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protease inhibitor I4, serpin, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003575">
        <property type="protein sequence ID" value="KVH99380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XYS6"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02043">
        <property type="entry name" value="serpinP_plants"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000012">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="15"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="431"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="805" mass="89288" checksum="0B6A5C252FBE624E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ68</accession>
    <name>A0A103XZ68_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_022166</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003437">
        <property type="protein sequence ID" value="KVH99602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ68"/>
    <dbReference type="STRING" id="59895.A0A103XZ68"/>
    <dbReference type="Gramene" id="KVH99602">
        <property type="protein sequence ID" value="KVH99602"/>
        <property type="gene ID" value="Ccrd_022166"/>
    </dbReference>
    <dbReference type="OMA" id="TIHVAFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000024">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="294"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVH99602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="562" mass="61464" checksum="36044A7FF9FC80B3" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZX8</accession>
    <name>A0A103XZX8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVH99961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZX8"/>
    <dbReference type="STRING" id="59895.A0A103XZX8"/>
    <dbReference type="Gramene" id="KVH99961">
        <property type="protein sequence ID" value="KVH99961"/>
        <property type="gene ID" value="Ccrd_021750"/>
    </dbReference>
    <dbReference type="OMA" id="FLMACIF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="43127" checksum="65068283131E264C" modified="2016-04-13" version="1">MNKHVSSEAMSEIFRKGKPFLAVIFLQFGLAGMDVISKVALNQGMSNYVFVVYRHVVATIVMTPFAIVLDKKIRPKMTLSIFVKLMLLALLEPVIDQNLYFMGMKATTATFAVSMCNVLPAITFVMACILRLEVVNLKSIRSQAKVIGTITTVAGAMLMTLVKGPILELFWTKGRTNSNVINNGVDLHHSLKGAIMITVGCFSWSCFMVLQAITLKSYPAELSLTAWICLLGTAEGAIVAMIMERGKTAVWAIKWDTTLLATLYSGIICSGLAYYIQGIIMKERGPVFVTAFSPLSMIIVAIMGSIILAEKTYLGRVIGAIVIVVGLYLVVWGKSKDNKLSSLSIGEPIAPEKQIPVKESEENSCNKVITIKASDEVISTNYTVCDKHSQTADLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0X9</accession>
    <name>A0A103Y0X9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA topoisomerase</fullName>
            <ecNumber evidence="12">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_021255</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01003385">
        <property type="protein sequence ID" value="KVI00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0X9"/>
    <dbReference type="STRING" id="59895.A0A103Y0X9"/>
    <dbReference type="Gramene" id="KVI00499">
        <property type="protein sequence ID" value="KVI00499"/>
        <property type="gene ID" value="Ccrd_021255"/>
    </dbReference>
    <dbReference type="OMA" id="MELAMGD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.20.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="17">
        <location>
            <begin position="175"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="763"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="860" mass="96721" checksum="78EC944385925ED6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1B4</accession>
    <name>A0A103Y1B4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KVI00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1B4"/>
    <dbReference type="Gramene" id="KVI00685">
        <property type="protein sequence ID" value="KVI00685"/>
        <property type="gene ID" value="Ccrd_021065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8338" checksum="78C2327FCC6F9513" modified="2016-04-13" version="1" fragment="single">MSRSLVIPDARQINKKRPHRLSLSRLSKIAVMFGILFTHFKLSIRFPPFAARIGNHLSAPHLATLPPRDGRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1V7</accession>
    <name>A0A103Y1V7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase substrate, phosphoprotein PP28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003151">
        <property type="protein sequence ID" value="KVI00982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1V7"/>
    <dbReference type="STRING" id="59895.A0A103Y1V7"/>
    <dbReference type="Gramene" id="KVI00982">
        <property type="protein sequence ID" value="KVI00982"/>
        <property type="gene ID" value="Ccrd_020754"/>
    </dbReference>
    <dbReference type="OMA" id="HYAKLTM"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="18495" checksum="4BA656E39C4294CD" modified="2016-04-13" version="1">MGRGKFKGKPTGRRQFSTTEEMIAGTSSRPRTFKKEAEVEEEERSEESEEESEEESERKKGPQGVIEIENPNTSKPKTMKARDVDLDKTTELSRREREEIEKQRAHERYMKLQEQGKTDQAKKDLERLALIRQQRAEAAKKREEEKAAKEQKKTEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y203</accession>
    <name>A0A103Y203_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Leaf</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003135">
        <property type="protein sequence ID" value="KVI01058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y203"/>
    <dbReference type="Gramene" id="KVI01058">
        <property type="protein sequence ID" value="KVI01058"/>
        <property type="gene ID" value="Ccrd_020678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10894" checksum="C50E44F0C42BC6F1" modified="2016-04-13" version="1">MDKRQGGGIRVRKGAFDDHEDIMKTIVFTEYRKQAIAFTPGRMKSISDEAHKRPQFLKRVDLVASAFYQHVDRNISKCMTNLPHRFGAMLAVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2Y7</accession>
    <name>A0A103Y2Y7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_020187</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003047">
        <property type="protein sequence ID" value="KVI01540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2Y7"/>
    <dbReference type="Gramene" id="KVI01540">
        <property type="protein sequence ID" value="KVI01540"/>
        <property type="gene ID" value="Ccrd_020187"/>
    </dbReference>
    <dbReference type="OMA" id="HENWAAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="39"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="407"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI01540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="695" mass="78338" checksum="0F6C95827182189F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4J4</accession>
    <name>A0A103Y4J4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4J4"/>
    <dbReference type="STRING" id="59895.A0A103Y4J4"/>
    <dbReference type="Gramene" id="KVI02390">
        <property type="protein sequence ID" value="KVI02390"/>
        <property type="gene ID" value="Ccrd_019341"/>
    </dbReference>
    <dbReference type="OMA" id="GWQNRAL"/>
    <dbReference type="OrthoDB" id="1882904at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="392"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LXXLL motif" evidence="3">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="468" mass="53504" checksum="83FAEEB76B19FDDF" modified="2016-04-13" version="1">MLGSSSCSQHHHQEQQQQQEVHLQTDPSPPPPPPPPGTAGQLHHHQIQQHQHQEVEMVSRLSSYTPPSIYLRQLLSSCAQSISNSDFAAAHRITTILSSNSSPYGDSSERLIHSFTKALSLRIRLHLNLPTPFPIKVNNFSNNSSSNYHDQNDDAILQSSYLSLNQITPFIRFSQLTANQAILEAIDQPQPQNHSFTSSPQPHDIHILDFDIMHGVQWPPLMQAIADRHHPPTLRITATGTNLDILRRTGDRLSKFAHSLGLRFRFFPLLLPDQTNNHHTVDDVINHLSAVLLLPNEILAVNCVLYLHRLLIDRDKLCLLLRKIKAMNPKVVTLAEREANHNHPLFLSRFEEALSYYTAIFDSLEATLPPNSRERMEVEQVWFGREIADIVTAEGEKRRERHERFLSWEMMMRIAGFRNVALSPFALSQAKLLLRLHYPSEGYNLEVVNDSFFLGWQNKPLFSVSSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4J7</accession>
    <name>A0A103Y4J7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4J7"/>
    <dbReference type="STRING" id="59895.A0A103Y4J7"/>
    <dbReference type="Gramene" id="KVI02392">
        <property type="protein sequence ID" value="KVI02392"/>
        <property type="gene ID" value="Ccrd_019343"/>
    </dbReference>
    <dbReference type="OMA" id="HSIANHR"/>
    <dbReference type="OrthoDB" id="1929441at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767:SF1">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114067" checksum="263E6CD3B1E0EEA2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4U0</accession>
    <name>A0A103Y4U0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4U0"/>
    <dbReference type="Gramene" id="KVI02534">
        <property type="protein sequence ID" value="KVI02534"/>
        <property type="gene ID" value="Ccrd_019271"/>
    </dbReference>
    <dbReference type="OMA" id="LNWVWNG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF20">
        <property type="entry name" value="F-BOX PROTEIN SKIP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="51520" checksum="E567294B10138275" modified="2016-04-13" version="1">MADDFFCDPKVSMFSSMKIGDWYRMDDYGDTSYDDGCGDYLNLNWEWKEVSEIMSHSQDVVDVLPSDPFEMNINGGCTMIRGWIEEVDDDDDDDDDDGIGCNTFRNRKDESDGLFSGLNLVWTETMRPIGDEIDIESSNGLFLFDGSKESNHGKVLYSDSINNGCHDDDDGGDHDHDLGSPPDALFFALGYLGMRDLLSVERVCKSLRDGVRNDPLLWRSIEIDQPSDEMFSDESLLRMTNRANESLQSLSLVKCSKITDNGLKTVFQRNPGLTKLSVLGCNGLSVEGLLNNLKFLKSTGGTGIKRLRIGGLHTVTTEQYEELKKALSSSLDNEKQLGYPKPRFYHGGQLYLSLDDNRPIDIEACPKCHQIRQIYDCPAEICQLRRVSCRACTFCIPRCINCGCCFNERDYMETFCLDFLCLDCLAQILSFPDGEEEDMSIPPGFHPQASYHFCLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y568</accession>
    <name>A0A103Y568_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002641">
        <property type="protein sequence ID" value="KVI02741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y568"/>
    <dbReference type="STRING" id="59895.A0A103Y568"/>
    <dbReference type="Gramene" id="KVI02741">
        <property type="protein sequence ID" value="KVI02741"/>
        <property type="gene ID" value="Ccrd_018966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000351">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000442">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g49710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF505">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT (PPR) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="663"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133412" checksum="96BF417E99A31995" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5Y7</accession>
    <name>A0A103Y5Y7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002508">
        <property type="protein sequence ID" value="KVI03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5Y7"/>
    <dbReference type="STRING" id="59895.A0A103Y5Y7"/>
    <dbReference type="Gramene" id="KVI03132">
        <property type="protein sequence ID" value="KVI03132"/>
        <property type="gene ID" value="Ccrd_018574"/>
    </dbReference>
    <dbReference type="OMA" id="ACINPHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056889">
        <property type="entry name" value="NET2A-D/KIP1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056888">
        <property type="entry name" value="NET2A-D/KIP1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31631">
        <property type="entry name" value="PROTEIN NETWORKED 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31631:SF0">
        <property type="entry name" value="PROTEIN NETWORKED 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25014">
        <property type="entry name" value="NET2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24918">
        <property type="entry name" value="NET2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51774">
        <property type="entry name" value="NAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="513"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="622"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="815" mass="93938" checksum="2380873ACFA2152F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y648</accession>
    <name>A0A103Y648_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002414">
        <property type="protein sequence ID" value="KVI03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y648"/>
    <dbReference type="STRING" id="59895.A0A103Y648"/>
    <dbReference type="Gramene" id="KVI03205">
        <property type="protein sequence ID" value="KVI03205"/>
        <property type="gene ID" value="Ccrd_018500"/>
    </dbReference>
    <dbReference type="OMA" id="QFMIIES"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="249"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="38940" checksum="794FC94566FBE572" modified="2016-04-13" version="1">MSNAVVNGLAGAGGGIIAQIITYPLQSVNTRQQTERIAKKSRSQGSSGGTLVQILQVIKSEGLGGLYSGLKPSLLGTATSQGIYYYFYQVFKNKAESIAAANKRKGHGDGTVGMFSWLVVAALAGSLNVLLTNPIWVLVTRMQTHTQAEQKIMEAKKEALLKESSESSLIGSSLHDKLRELDSMKPNPYGTLNAAYEVYNEAGILGFWKGIIPTMIMVCNPSIQFMIYESSIKHLKTKRADKKQNSTKVTALEVFLVGAIAKLGATVTTYPLLVVKSRLQAKQEISRNNSLRYSGTMDAIVKMIHYEGLSSFYKGMSTKIVQSVFAASVLFMIKEELVNLFSVLLLTMSKSNPHPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9B2</accession>
    <name>A0A103Y9B2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_016775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01001901">
        <property type="protein sequence ID" value="KVI04897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9B2"/>
    <dbReference type="STRING" id="59895.A0A103Y9B2"/>
    <dbReference type="Gramene" id="KVI04897">
        <property type="protein sequence ID" value="KVI04897"/>
        <property type="gene ID" value="Ccrd_016775"/>
    </dbReference>
    <dbReference type="OMA" id="AIMDELI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000043">
        <property type="entry name" value="probable methyltransferase PMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1165">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI04897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="682" mass="77089" checksum="9B56CD516DF81904" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9G8</accession>
    <name>A0A103Y9G8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001892">
        <property type="protein sequence ID" value="KVI04984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9G8"/>
    <dbReference type="STRING" id="59895.A0A103Y9G8"/>
    <dbReference type="Gramene" id="KVI04984">
        <property type="protein sequence ID" value="KVI04984"/>
        <property type="gene ID" value="Ccrd_016685"/>
    </dbReference>
    <dbReference type="OMA" id="WLMKCPA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF2">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIF, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="8">
        <location>
            <begin position="192"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="262" mass="29924" checksum="ABAD268F8F24EEFF" modified="2016-04-13" version="1">MDDPINATTKISVSAKANSGGGQKLLETSKSERHVWLMKCPPIVSRSLSQQQPHLPSPPDSSSAPITAKVIVNVDPLLPNEDFSSTQLELLGTDQSGRVPKCYSMDMSKDIIPMSVFSESKQDFYLANSYTSGRLSVEGTIYYKFDMKPHNENLEEYGKLCRERTNKYMTKTRQIQERKKAPVKGSDTKRTRRDRGEMEDIMFKLFERQSNWTLKQLISETDQPEQFLKDLLKDLCIYNNKGSNQGTYELKPEYKRSTEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9S8</accession>
    <name>A0A103Y9S8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL10-like insertion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001889">
        <property type="protein sequence ID" value="KVI05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9S8"/>
    <dbReference type="STRING" id="59895.A0A103Y9S8"/>
    <dbReference type="Gramene" id="KVI05123">
        <property type="protein sequence ID" value="KVI05123"/>
        <property type="gene ID" value="Ccrd_016555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12287" checksum="410A87084270CA16" modified="2016-04-13" version="1">MVLAYNMTLCYYQVGLVAPVAVVVPPGNTGLDPSQTSFFQVLIFVLNIPTKINKGTVEIITLVELIKKGDKVGSSEAALLAKLGIRPFSYSLVVLTVYDNGSVFYHYMLALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAL2</accession>
    <name>A0A103YAL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAL2"/>
    <dbReference type="Gramene" id="KVI05547">
        <property type="protein sequence ID" value="KVI05547"/>
        <property type="gene ID" value="Ccrd_016179"/>
    </dbReference>
    <dbReference type="OMA" id="GYSHESD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF195">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="44470" checksum="5479BC0EE939B66F" modified="2016-04-13" version="1">MDNLVELSLRGSGIEIVPSSIGQYCNNLVSLDLRRCKYLLSIEHNFHLLKHLQLLCLDSCVQLKNIPTEGAVNEFLRFPCFLRRLSLGGCNLVDEDISVFWEELSNLQVLDLSRNKFSRLHPSLSQLPRLKFIDLSDCYNLVELPDLPSSISILIANGCTSLKIGDFPTNHLKWLWKVSLSTRNCNGERILESMLQGNAIEDYFISILIENCYVPIRGFARETFTLQLPWNWYSEFCGFLISIKSLNGNMEEVIVIKDVLGMENGDGVLDKPDHHDDDDDDEEEESRTAAAAAAAAIAMCYISFGSLRNTSWWNSTHTTLSFSLQTNYDLIVELVPGRNQGDDSILKDATYLSNFWDEEFLNKKTFEIVSDSKSSIQIQWDTGIRLDMVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAS9</accession>
    <name>A0A103YAS9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAS9"/>
    <dbReference type="STRING" id="59895.A0A103YAS9"/>
    <dbReference type="Gramene" id="KVI05661">
        <property type="protein sequence ID" value="KVI05661"/>
        <property type="gene ID" value="Ccrd_016019"/>
    </dbReference>
    <dbReference type="OMA" id="WATISRC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030380">
        <property type="entry name" value="SAM_MeTfrase_DRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF54">
        <property type="entry name" value="DNA (CYTOSINE-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51680">
        <property type="entry name" value="SAM_MT_DRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase DRM-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI05661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="43771" checksum="14B85AA951FC07D8" modified="2016-04-13" version="1" fragment="single">PKDKKRKFQKDNFWSKNKKFDRKNESKSKDEDHEVLHLPNPMVGFGVPREPFHVVRRTLPEAAIGPPFFYYENVALTPKGAWNRIKSFLYEIDPEFVDSKFFCAAARKRGYIHNLPLENRFPIQPLPPLTIFEALPGTKKWWPSWDKREQLNCILTCIGSAQLTDRIRLALENSNTEPSLHVKNYIIGQCRKWNMVWTGKTRVAPLEPDEIELIMGYPIYHTRGASRVERYKGLGNAFQVDTVAYHLSVLKNLYPNGMNILSLFSGIGGAEIALHKLGIPLNNVVSVEKSMVCRNILQGWWEQTNQKGNLVHLSDVQDVTLNKLNQWIDSFGGFDLVIGGSPCNNLAGGNRRTRDGLEGGHSSLFFDYFRILDGVKNLMKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAY5</accession>
    <name>A0A103YAY5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose 1-/Glucose-6-phosphate 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAY5"/>
    <dbReference type="STRING" id="59895.A0A103YAY5"/>
    <dbReference type="Gramene" id="KVI05754">
        <property type="protein sequence ID" value="KVI05754"/>
        <property type="gene ID" value="Ccrd_015971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF51">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119552" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="33759" checksum="621079A79FDBA618" modified="2016-04-13" version="1">MDVLSFFLLLTVTLSFIHLIKSQMGLSTKTLISIGYPSQSIKINNIKTKAGVDKREPISEEDKIVEVVLLYGGKVVSWKNSQGEELLFMSRKAAGRSSKGGISLCFPQLGNTGTIKEICSSKNNVRSLDNIPLRLTPTGNPSSVDLTLKTTANNSNMWPRSFEFRLRVSLGPDKMTMISHIKNTDSTSFSFTIALQNYFSVSDIRTPGNIAIIDHDKKRTIVIRNEGLPDAVLWTPWDNAAKAAASGFCDKDYKMMLSVDSGVLEKLIILKPSEEWKGYQELSIISSSYCSGQLDPKMVAFYAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBV9</accession>
    <name>A0A103YBV9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBV9"/>
    <dbReference type="Gramene" id="KVI06244">
        <property type="protein sequence ID" value="KVI06244"/>
        <property type="gene ID" value="Ccrd_015420"/>
    </dbReference>
    <dbReference type="OMA" id="PTIYVFN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF16">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="470" mass="52428" checksum="4E4C09FDAED43CE8" modified="2016-04-13" version="1">MMMKHSFYGIGIHPSVFRLLSARKFFTSPLYFNRSYTFAASFHSSNRNCKEVTDLKTLEDAVYTFNHMSRRNPVPPIQEFTKVLACIVNMKHFDAAISLITQFDLLGVNPFLKPTIYVFNITINCFCHLKRVNCGFAVLGKATKLGYVPDCATFNTLIRGLCANDKLHQAIRLFNQLVESKFEPSVVTYGTLMNGLCKSGDTHAAILLLRKMETSISPPGIIQYSTIIDSLCKDKQFVEALDLFSEMNRKGISPNVVTYTCLIQGLCSIRSWEEAMRLLSEMLARNISPNVHTFTVLMDALCKEGRVIEAQNIFTYNTILDALCKNRKLDEGLNLFNMLDGDGPPPDIVTCNCLIDGLCKSGETDTAFGILSSLSARGLQPNVRTYNIMIDGFCKKGELDKANTLFLEMKRNGCPADDITYKIMVQGFLRANETTKAAEFLSGSLDASFSADANKLLNKLFSDGFNDSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCP6</accession>
    <name>A0A103YCP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001771">
        <property type="protein sequence ID" value="KVI06664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCP6"/>
    <dbReference type="Gramene" id="KVI06664">
        <property type="protein sequence ID" value="KVI06664"/>
        <property type="gene ID" value="Ccrd_014988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="69" mass="7659" checksum="73E7429A421D3191" modified="2016-04-13" version="1">MISPYSSILRTHYTNAASVHFLQGMAEASDLLGGGFARRKIWRGKTLRLHFAATDESLPPPYSSAFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCW2</accession>
    <name>A0A103YCW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001666">
        <property type="protein sequence ID" value="KVI06755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCW2"/>
    <dbReference type="STRING" id="59895.A0A103YCW2"/>
    <dbReference type="Gramene" id="KVI06755">
        <property type="protein sequence ID" value="KVI06755"/>
        <property type="gene ID" value="Ccrd_014891"/>
    </dbReference>
    <dbReference type="OMA" id="NERSMSK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052799">
        <property type="entry name" value="Rho_GAP_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265:SF26">
        <property type="entry name" value="RHO GTPASE ACTIVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="175"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="638" mass="70306" checksum="C84080E56DF1CCC1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCY2</accession>
    <name>A0A103YCY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001634">
        <property type="protein sequence ID" value="KVI06785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCY2"/>
    <dbReference type="STRING" id="59895.A0A103YCY2"/>
    <dbReference type="Gramene" id="KVI06785">
        <property type="protein sequence ID" value="KVI06785"/>
        <property type="gene ID" value="Ccrd_014859"/>
    </dbReference>
    <dbReference type="OMA" id="MWWDEEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45504">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45504:SF3">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="71" mass="8765" checksum="59C8F95A938864C7" modified="2016-04-13" version="1">MRWDEMKGNFMHHKQEQEPPQHEQHDSSYLSFDSLSPNFKPKDYYRKLEVHYEVTEEEIRPNYIRLALVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDG3</accession>
    <name>A0A103YDG3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001524">
        <property type="protein sequence ID" value="KVI07074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDG3"/>
    <dbReference type="Gramene" id="KVI07074">
        <property type="protein sequence ID" value="KVI07074"/>
        <property type="gene ID" value="Ccrd_014551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="33416" checksum="DC8934EFECAD208E" modified="2016-04-13" version="1">MHFLMHLQASATLFESTYKSSGCSKRLLNTFSSFYIQLVSPLVSYAGENLEAIYRGSRFHPPCEIRRACDQRRVSDRRWGYGGGPEVKELGEGLMRGKEPYIGGVSEKGALSKKIEGIDAKRADPLTPHGVIVFQENDFLNPVCLSFFRRLSSASLTFGSGNTASVGSSRCRTSDLRATLTCFSTFSSPFFAMGSVSFMVWFALLMGSDLTLLLSPPPRMDEKAVARATTKFGFVRAGTMSARAAGDGLWYISDEDPAIVIEFPAILSLSLSLSLSFPVLSLFYHMVCGLVVILSCLQSLVLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEA2</accession>
    <name>A0A103YEA2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family. Plant F-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEA2"/>
    <dbReference type="STRING" id="59895.A0A103YEA2"/>
    <dbReference type="Gramene" id="KVI07476">
        <property type="protein sequence ID" value="KVI07476"/>
        <property type="gene ID" value="Ccrd_014170"/>
    </dbReference>
    <dbReference type="OMA" id="SWPTKQS"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="20391" checksum="40DA1982EC874A91" modified="2016-04-13" version="1">MALQIHHLRPPIPPAAALCSVGSLSSWPTKQSTIAGDLRRSFSLVKMIDSKTRKNKGLRYSVRVRSSLETSGSAAVVGQVTEVDKDTFWPIVNAAGDKTVVLDMYTQWCGPCKMIAPKIEELAEKYLDVVFLKLDCNQENKPLAKELGIKVVPTFKILKQGKIIKEVTGAKFDDLVTAMEDVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YED5</accession>
    <name>A0A103YED5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_014071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family. SR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YED5"/>
    <dbReference type="STRING" id="59895.A0A103YED5"/>
    <dbReference type="Gramene" id="KVI07537">
        <property type="protein sequence ID" value="KVI07537"/>
        <property type="gene ID" value="Ccrd_014071"/>
    </dbReference>
    <dbReference type="OMA" id="HAYFALH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12599">
        <property type="entry name" value="RRM1_SF2_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000062">
        <property type="entry name" value="serine/arginine-rich splicing factor SR34A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000244">
        <property type="entry name" value="serine/arginine-rich splicing factor SR34A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="311" mass="35152" checksum="45D5E5A79F130D48" modified="2016-04-13" version="1" fragment="single">GDEASNSNTGIPENGKRPSRFSVAVKFNQFVLIYGAIYLELKMSGCFSRTIYVGNLPLDIREWEVEDLFYKYGRILDIELKIPPRPPCYCFVEFANARDAEDAIRGRDGYNFDGCRLRVELAHGGRGQSSSGDGRGDYGGGHRSGSSSGRFGISQHSEYRDQFPICAFKNFATLRLFCAVVVRGLPSSASWQDLKDHMRRAGDVCFAEVSRDSEGTFGLVDYTNYEDMKYAIRKLDDTEFRNPWTKTYIRVRKYDRSPSRSPSRSCSRGRSKSLQRSPSESRSASPGKPTRSRSRLRSKSMSESPRKVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEH1</accession>
    <name>A0A103YEH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEH1"/>
    <dbReference type="Gramene" id="KVI07619">
        <property type="protein sequence ID" value="KVI07619"/>
        <property type="gene ID" value="Ccrd_014012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00062">
        <property type="entry name" value="Shadow ORF (opposite ABC transporter protein)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="16870" checksum="9EC0F23B702330F3" modified="2016-04-13" version="1" fragment="single">MVAIKIDEMHCTMTAIRSDIMVLTVEVSFMIREVREPTLFSGLSNHANSLRSTAKPKTGFEMPENAAAQDPTPIFTNSRKLLCVPVSVTCPFCTTTIISAFTMVDILCAIKMTVLPFIALSNAESSALVASSSKRIGGFFNMALAIAILCFCPPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEJ6</accession>
    <name>A0A103YEJ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEJ6"/>
    <dbReference type="Gramene" id="KVI07627">
        <property type="protein sequence ID" value="KVI07627"/>
        <property type="gene ID" value="Ccrd_014020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="13814" checksum="08FB638EB1D5D74B" modified="2016-04-13" version="1" fragment="single">MQIGGLTPANARIEEGRIHNPSPQIKPEATAGTIRKNVRGATTHPMAVPIAWLTSIDLGEVRRKSRPLILSNHIQQVQPQHHFAFRTLQQAQKEQPSRNYMPYSCLLNQHHRHYKSPKMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG45</accession>
    <name>A0A103YG45_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001118">
        <property type="protein sequence ID" value="KVI08452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG45"/>
    <dbReference type="STRING" id="59895.A0A103YG45"/>
    <dbReference type="Gramene" id="KVI08452">
        <property type="protein sequence ID" value="KVI08452"/>
        <property type="gene ID" value="Ccrd_013171"/>
    </dbReference>
    <dbReference type="OMA" id="KMYLVNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47198">
        <property type="entry name" value="OS05G0299300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47198:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="4">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="564"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="657"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="691" mass="77099" checksum="4541415375714A5B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHL2</accession>
    <name>A0A103YHL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyl transferase, family 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_012357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHL2"/>
    <dbReference type="STRING" id="59895.A0A103YHL2"/>
    <dbReference type="Gramene" id="KVI09269">
        <property type="protein sequence ID" value="KVI09269"/>
        <property type="gene ID" value="Ccrd_012357"/>
    </dbReference>
    <dbReference type="OMA" id="KMIDTIP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044782">
        <property type="entry name" value="SIA1/STLP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47486">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47486:SF1">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI09269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="39783" checksum="91E90B3D869806F1" modified="2016-04-13" version="1">MTRPLKPSSRRPAFVHLICAATIFSVLVFAIQSFFFTGSQTKYLNTEDVQILSDFQSDVQQCVYRNMTTVLTREYLDARPDGWMDYAAKRIAQLGAKNCNNRTLCEEHLNPILPAKPPFHPRQFQKCAVVGNSGDLLKTEFGKEIDSHDAVIRDNEAPVNEKYAKHVGLKRDFRLGVRGTARNMVTILNGSDDEVLVIKSVTHRDFNKMIDTIPNPVYLFQGIVIRIHSPMRAKRVQDWSDVPTREKIGRAHAAAMRLKRSQEGGDGAVGQFSNCKVWGNAGPYGSGPVSGSRDMSSKRKNSNYSKWEVMPFKSLRQEAQEHYVQMEGVSVYKMDGNKLDDLVCVKHPLESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ51</accession>
    <name>A0A103YJ51_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ51"/>
    <dbReference type="Gramene" id="KVI10071">
        <property type="protein sequence ID" value="KVI10071"/>
        <property type="gene ID" value="Ccrd_011533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119779" evidence="2">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="18210" checksum="D225558693727343" modified="2016-04-13" version="1">MVFMGGFMMILFLVPFHPWMKLIMQHPLYNSLIVQRMVISLSSDKSVWEAVMNNEVRDSVYEGCSTWDPYQHEGEVMEIVEKIRDGEQYPRNENTGEGEGAATEPFEKFFLSFGYGPPDHSLESGLQDSNPSADDDNDGFSSRSPSFVAAEDALLCRRGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK99</accession>
    <name>A0A103YK99_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma thionin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001003">
        <property type="protein sequence ID" value="KVI10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK99"/>
    <dbReference type="Gramene" id="KVI10701">
        <property type="protein sequence ID" value="KVI10701"/>
        <property type="gene ID" value="Ccrd_010897"/>
    </dbReference>
    <dbReference type="OMA" id="KQCIRVE"/>
    <dbReference type="OrthoDB" id="1851987at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33147">
        <property type="entry name" value="DEFENSIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33147:SF98">
        <property type="entry name" value="GAMMA-THIONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00304">
        <property type="entry name" value="Gamma-thionin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119812" evidence="4">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="13164" checksum="649EAD305048952B" modified="2016-04-13" version="1">MAKNSVAFFALLLLICILTISEFAVVKGELCEKASKTWSGNCGNTRHCDDQCKAWEGAAHGACHTRNKKHMCFCYFNCPKAEKLAQDKLKAEELARDKVEAKEVPHFKHPIEPIHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL74</accession>
    <name>A0A103YL74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000867">
        <property type="protein sequence ID" value="KVI11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL74"/>
    <dbReference type="STRING" id="59895.A0A103YL74"/>
    <dbReference type="Gramene" id="KVI11166">
        <property type="protein sequence ID" value="KVI11166"/>
        <property type="gene ID" value="Ccrd_010426"/>
    </dbReference>
    <dbReference type="OMA" id="HHLNTAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7467" checksum="98E29C9AA58F4C3F" modified="2016-04-13" version="1">MGFVDLLSAASMPVLKVLIITALGSFLAMHHIDILGQTTRKQVNNLWIEQIRSTLRIGMDQVQVVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMK9</accession>
    <name>A0A103YMK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Src homology-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_009720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000031">
        <property type="protein sequence ID" value="KVI11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMK9"/>
    <dbReference type="STRING" id="59895.A0A103YMK9"/>
    <dbReference type="Gramene" id="KVI11862">
        <property type="protein sequence ID" value="KVI11862"/>
        <property type="gene ID" value="Ccrd_009720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053296">
        <property type="entry name" value="TSET_member_tstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48151">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48151:SF3">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13870" checksum="7687580FA92A2C61" modified="2016-04-13" version="1" fragment="single">MWAKTLLEPSELDDDESSSSSSPDSLASAETSISSQFGGMNYPSLFSSKEEPTPYSSPFHQSYESFVNLLAGTDSGYKYIDEDRSSSVNMEFGTALFDFTAGGDDELSLVSGEELEIEYEVDGWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMP8</accession>
    <name>A0A103YMP8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rab5-interacting</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000024">
        <property type="protein sequence ID" value="KVI11944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMP8"/>
    <dbReference type="STRING" id="59895.A0A103YMP8"/>
    <dbReference type="Gramene" id="KVI11944">
        <property type="protein sequence ID" value="KVI11944"/>
        <property type="gene ID" value="Ccrd_009634"/>
    </dbReference>
    <dbReference type="OMA" id="ANSEWPD"/>
    <dbReference type="OrthoDB" id="286395at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14018" checksum="44A3956D10856B6F" modified="2016-04-13" version="1">MKEKKSVKSSDKHQSGHVSSFKFAKLFDPEAFWDKDQLGDVLHWIRQIVALVCGLLWGSIPLVGGIWLVSFLLISSGIIYGYYAIILKVDEEEFGGHGSLLQEGLFASITLFLLAWTLVYSLAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN07</accession>
    <name>A0A103YN07_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="17">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_009475</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN07"/>
    <dbReference type="STRING" id="59895.A0A103YN07"/>
    <dbReference type="Gramene" id="KVI12111">
        <property type="protein sequence ID" value="KVI12111"/>
        <property type="gene ID" value="Ccrd_009475"/>
    </dbReference>
    <dbReference type="OMA" id="KFTRPAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000008">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000029">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF8">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 17 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11 18" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="20">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="20">
        <location>
            <begin position="292"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="554"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="626" mass="70096" checksum="F91F6C9631F08B66" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNR6</accession>
    <name>A0A103YNR6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein TIFY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Jasmonate ZIM domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_009167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Repressor of jasmonate responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The jas domain is required for interaction with COI1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TIFY/JAZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000003">
        <property type="protein sequence ID" value="KVI12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNR6"/>
    <dbReference type="STRING" id="59895.A0A103YNR6"/>
    <dbReference type="Gramene" id="KVI12400">
        <property type="protein sequence ID" value="KVI12400"/>
        <property type="gene ID" value="Ccrd_009167"/>
    </dbReference>
    <dbReference type="OMA" id="TIQTVKM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040390">
        <property type="entry name" value="TIFY/JAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077">
        <property type="entry name" value="PROTEIN TIFY 4A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077:SF60">
        <property type="entry name" value="TIFY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00979">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1184">Jasmonic acid signaling pathway</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tify" evidence="4">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="209" mass="23029" checksum="CC37B878F4A63B07" modified="2016-04-13" version="1" fragment="single">MTTEESPLSVSTTSLLDKPLHQLTEDDISQLTREDCRRYLKQKGMRRPSWNKSQAIQQVIMLKALLEPKPDSDGCNRKLHITHRQQETPTTRVQKGTSADTEVSVSADESVPGQRNDVDLSDLPGDDEFVPMGIAGVTDEAKGQMTIFYSGMVNVYDDVPAEKAWTLFQLAAIPLQFSQEAPFDGNVTMCPLTCNLQAPNIKASADSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118DKP9</accession>
    <name>A0A118DKP9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_024048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011190">
        <property type="protein sequence ID" value="KVE16608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118DKP9"/>
    <dbReference type="STRING" id="59895.A0A118DKP9"/>
    <dbReference type="Gramene" id="KVE16608">
        <property type="protein sequence ID" value="KVE16608"/>
        <property type="gene ID" value="Ccrd_024048"/>
    </dbReference>
    <dbReference type="OMA" id="FAKYCTL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004:SF439">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVE16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42599" checksum="4C75071FEF128886" modified="2016-04-13" version="1">MSYLLYLDMSDNRFDGEIPQCLGNISSNLVMVDLGNNNFHGTIPNTWDDCGKLEGLILNGNSLEGEVPSGLSECKSLKVLDLGNNHLTGTFPHWSANLQHLQVLVLKSNKLHGPIETSSIVEHPFSSLKVLDLSQNNFIGHLPRNYFQNFDAMKNREVKKRTKPEYLSIGKFYSITVAVKGSELPFTKISVDYTIVDLSSNIFEGGILDVIGSLSSLIVLNLSHNNLNDRIPKAIGNLLKIESLDLSCNQLKGEIPQSLAFITDLEVLNLSQNHLVGRIPDGTQFRTFEATSFEGNPGLCGFPLPKQCEHLSAPQLEIDEDEDSGFTWKVVMLGYGCGTLLGLGMGYMMLSTGRPKWFNAIADEIEHMIMQRQKKRRHVYIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRN8</accession>
    <name>A0A118JRN8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006323">
        <property type="protein sequence ID" value="KVH86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRN8"/>
    <dbReference type="Gramene" id="KVH86802">
        <property type="protein sequence ID" value="KVH86802"/>
        <property type="gene ID" value="Ccrd_025417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15767" checksum="AD4F1D4796A56EFE" modified="2016-04-13" version="1">MDGSYRGVLPSRSCMGQTEIHRAAWTCSIKSINSNEEAETYLTENLDKRDVKIAEYKVVRKLKESTIVCSCNHIGRHGYLCRHVFKVLLNVGVESIPEEYILIRWRRDLIPIELQNSRQIICDVGEDQRRIKRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRV4</accession>
    <name>A0A118JRV4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006219">
        <property type="protein sequence ID" value="KVH87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRV4"/>
    <dbReference type="STRING" id="59895.A0A118JRV4"/>
    <dbReference type="Gramene" id="KVH87442">
        <property type="protein sequence ID" value="KVH87442"/>
        <property type="gene ID" value="Ccrd_025319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="11872" checksum="F1768E28F5D3FC56" modified="2016-04-13" version="1">MALKGRKLEEHRDLGYVSHRRDVIAGGGREIKQLLKEAAQRWRPYSFINEGTLGCGIGHSISPLTISIMAKIGFAELIDLCPIHATDVKLPAGGSFVIANSLTLWCATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSA6</accession>
    <name>A0A118JSA6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_026701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005393">
        <property type="protein sequence ID" value="KVH88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSA6"/>
    <dbReference type="STRING" id="59895.A0A118JSA6"/>
    <dbReference type="Gramene" id="KVH88482">
        <property type="protein sequence ID" value="KVH88482"/>
        <property type="gene ID" value="Ccrd_026701"/>
    </dbReference>
    <dbReference type="OMA" id="YESTHSH"/>
    <dbReference type="OrthoDB" id="676764at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045277">
        <property type="entry name" value="DRE1A-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31839:SF62">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31839">
        <property type="entry name" value="DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="21765" checksum="86DE27A0CFBAB80B" modified="2016-04-13" version="1">MKNAFLAVGEVMLAAENPKKKAGRKKFKETRHPVYRGVRRRNTGKWVCEVREPNTKLRVWLGTHPTAEMAARAHDVAILAMRGRSACLNFADSIWRLPVPESKQIKDIQKAAAEAAEAFRPRLDQVMEIDDEREEWPEISFYSDEEMFERPGYLDSMGPLLMVLPPQTSGDDVDFMGNITIQFHHSFFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSJ5</accession>
    <name>A0A118JSJ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily domain, general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005526">
        <property type="protein sequence ID" value="KVH88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSJ5"/>
    <dbReference type="STRING" id="59895.A0A118JSJ5"/>
    <dbReference type="Gramene" id="KVH88197">
        <property type="protein sequence ID" value="KVH88197"/>
        <property type="gene ID" value="Ccrd_024409"/>
    </dbReference>
    <dbReference type="OMA" id="HGFEFNF"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17351">
        <property type="entry name" value="MFS_NPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69559" checksum="044678EA645400DF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU02</accession>
    <name>A0A118JU02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monogalactosyldiacylglycerol synthase</fullName>
            <ecNumber evidence="2">2.4.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Plastid</location>
            <location evidence="5">Chloroplast membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.46" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004912">
        <property type="protein sequence ID" value="KVH91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU02"/>
    <dbReference type="STRING" id="59895.A0A118JU02"/>
    <dbReference type="Gramene" id="KVH91674">
        <property type="protein sequence ID" value="KVH91674"/>
        <property type="gene ID" value="Ccrd_006301"/>
    </dbReference>
    <dbReference type="OMA" id="WIERINQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046509">
        <property type="term" value="F:1,2-diacylglycerol 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050519">
        <property type="entry name" value="Glycosyltransf_28_UgtP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43025">
        <property type="entry name" value="MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43025:SF3">
        <property type="entry name" value="MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Diacylglycerol glucosyltransferase N-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Diacylglycerol glucosyltransferase N-terminal" evidence="7">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="6">
        <location>
            <begin position="293"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="50058" checksum="DE174E9722539189" modified="2016-04-13" version="1">MTTTAHGTHNTITTTSRLDGYSSIVSNFVHYDRKAGDFWSGGGRRKSSSKVVASLSSGSRGGSSSINKFFNEFNKFVRFHCDRIPLGFGSIKLSSENICGLGEGNGGVLEDETLPLSGFESNGKKKVLILMSDTGGGHRASAEAIKWAFNEKFGDEYEVFVTDLWTDHTPWPFNQLPRSYNFLVKHGSLWRMTYYASAPRVRGCERSYEVPARYYHQCTSSNATCTSSHLEVKGCYCPTEEVAKRALKAGLQSSQIKVYGLPVRPSFVKPIRPKDELRRELGMDEDLPAVLLMGGGEGMGPIEATAKALGNALFDENLGEPIGQVLVICGRNKKLANKLLSTEWKIPIQVKGFVTKMEECMGACDCIITKAGPGTIAEAMIRGLPIILNDYIAGQSPKEIAHIVGQWFGPRAHELQAMSQNALRLARPDSVFKIVQDLHELVKQRSLIMQYSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUH0</accession>
    <name>A0A118JUH0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_006827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005072">
        <property type="protein sequence ID" value="KVH91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUH0"/>
    <dbReference type="STRING" id="59895.A0A118JUH0"/>
    <dbReference type="Gramene" id="KVH91167">
        <property type="protein sequence ID" value="KVH91167"/>
        <property type="gene ID" value="Ccrd_006827"/>
    </dbReference>
    <dbReference type="OMA" id="HMDATST"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF60">
        <property type="entry name" value="SHAGGY-RELATED PROTEIN KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="109"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="347" mass="39105" checksum="1925E37B790997BF" modified="2016-04-13" version="1" fragment="single">MNVMRRLKSIASGRSSVSDPGGDSSIKRVKVEQEVESHVIGGPQSVDQRTDDVEQHMDATSTDMAASTSNTSSIAKPEKSDFDELPKEMHEMKIKEDKSEDKLLVKQEIEATVVNGNGTEKGQIIVTTAKCLETGESVAIKKVLQDKRYKNRELQIMRLLDHPNVVPLKNCFYSTTEKNEVYLNVVLEYVPETVYRVSRHYSRMTQHIPLIYVQLYTYQVNPHTHQLKLCDFGSAKMLVPGEPNISYICSRYYRAPELIFGATEYTNAIDMWSAGCVLAELLLGQPLFPGESGVDQLVEIIKILGTPTREEIKCMNPHYTEFNFCVHSNKKKENSSSCNSNKPVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV35</accession>
    <name>A0A118JV35_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="11" type="ORF">Ccrd_004898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004797">
        <property type="protein sequence ID" value="KVH93056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV35"/>
    <dbReference type="STRING" id="59895.A0A118JV35"/>
    <dbReference type="Gramene" id="KVH93056">
        <property type="protein sequence ID" value="KVH93056"/>
        <property type="gene ID" value="Ccrd_004898"/>
    </dbReference>
    <dbReference type="OMA" id="RRMRMFP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF77">
        <property type="entry name" value="MLO-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="515" mass="58908" checksum="D5598DA4F2E6633F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWG8</accession>
    <name>A0A118JWG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_003744</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004563">
        <property type="protein sequence ID" value="KVH94195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH94195">
        <property type="protein sequence ID" value="KVH94195"/>
        <property type="gene ID" value="Ccrd_003744"/>
    </dbReference>
    <dbReference type="OMA" id="MATFMAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19990">
        <property type="entry name" value="PBP1_GABAb_receptor_plant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000037">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044440">
        <property type="entry name" value="GABAb_receptor_plant_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159762" evidence="14">
        <location>
            <begin position="28"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1550"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2204"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2234"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2264"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2430"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="458"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="2079"/>
            <end position="2409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH94195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2525" mass="282923" checksum="FD8173B92A6E20A7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX55</accession>
    <name>A0A118JX55_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004328">
        <property type="protein sequence ID" value="KVH96341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX55"/>
    <dbReference type="STRING" id="59895.A0A118JX55"/>
    <dbReference type="Gramene" id="KVH96341">
        <property type="protein sequence ID" value="KVH96341"/>
        <property type="gene ID" value="Ccrd_001574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="19443" checksum="DE177477368A934E" modified="2016-04-13" version="1">MPFVTEELWQRLPAPQHYPREKCIMICKYPSLVECWTNERVEYEMGMVESTVSDQSKRTYLQKKEMKVSRTDQIVDLLRRHEMEVSTLANLSSFTVFMTLNKTMSAKGYEENLNKTMSAKGYEEKVPAHVKEENVSKLATLMQQLLSIEEAAQHFEREAAAKASALQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYF6</accession>
    <name>A0A118JYF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYF6"/>
    <dbReference type="STRING" id="59895.A0A118JYF6"/>
    <dbReference type="Gramene" id="KVH97747">
        <property type="protein sequence ID" value="KVH97747"/>
        <property type="gene ID" value="Ccrd_000146"/>
    </dbReference>
    <dbReference type="OMA" id="HWCNEKA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022143">
        <property type="entry name" value="DUF3675"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033275">
        <property type="entry name" value="MARCH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012:SF196">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12428">
        <property type="entry name" value="DUF3675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20197" checksum="EA790DEF23433CB6" modified="2016-04-13" version="1">MVGPSSSTDVARAVDENGALDDEEAPLLTIAECRICQEEDSIDKLETPCACNGSLKYAHRKCVQHWCNEKAERQFLEAEYEDYNASNASGAAFCRSAVLILMALLLLRHALFLLRVAGFLLPCYIMAWAISILQRRRQRQEAAALAASQIAFVLQRRGLHFAIAQAPAPAAVAIPVVTPQENNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZC6</accession>
    <name>A0A118JZC6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003795">
        <property type="protein sequence ID" value="KVH98470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZC6"/>
    <dbReference type="STRING" id="59895.A0A118JZC6"/>
    <dbReference type="Gramene" id="KVH98470">
        <property type="protein sequence ID" value="KVH98470"/>
        <property type="gene ID" value="Ccrd_023309"/>
    </dbReference>
    <dbReference type="OMA" id="NIQFYMH"/>
    <dbReference type="OrthoDB" id="1928589at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008191685" description="Dirigent protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="181" mass="19513" checksum="14917C5071734677" modified="2016-04-13" version="1">MAYTSKLLCFVLVAFLVASVSEARKRNTTNIQFYMHDSPSGPNPSAVRVAGQPVNATVSNNTDASMFGFGSIYVMDNALTATPDINSTLIGRAQGLYAIASQENALSLHMTLTYNFVSGIYNGSSVSVVGQNPVMNEVREMPVVGGTGVFRLARGFALAKTYSMNQWDAIIGYNVTIIPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K216</accession>
    <name>A0A118K216_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha crystallin/Hsp20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K216"/>
    <dbReference type="Gramene" id="KVI03645">
        <property type="protein sequence ID" value="KVI03645"/>
        <property type="gene ID" value="Ccrd_018055"/>
    </dbReference>
    <dbReference type="OMA" id="DMEEKND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06472">
        <property type="entry name" value="ACD_ScHsp26_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000009">
        <property type="entry name" value="17.6 kDa class I heat shock protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="164"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="31744" checksum="BD704B14A2ECDBB0" modified="2016-04-13" version="1">MSIIPSLFNGRRSSIFDPFSLDIWEPLRDFPIPSSSDVSSAFVNTRVDWKETPEAHVFKADLPGIKKEEAKVEVEDGRVLQISGERNVXKEDXNDRWHRXERXSGKFTRRFRLPENAKMDEVKAAMENGVLTITVPKEEVKKPDVKSIEISPLRDFPIPSSSDVSSAFVNTRVDWKETPEAHVFKADLPGIKKEEAKVEVEDGRVLQISGERNVEKEDNNDRWHRVERSSGKFTRRFRLPENAKMDEVKAAMENGVLTITVPKEEVKKPDVKSIEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2R1</accession>
    <name>A0A118K2R1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_016903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001913">
        <property type="protein sequence ID" value="KVI04773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2R1"/>
    <dbReference type="STRING" id="59895.A0A118K2R1"/>
    <dbReference type="Gramene" id="KVI04773">
        <property type="protein sequence ID" value="KVI04773"/>
        <property type="gene ID" value="Ccrd_016903"/>
    </dbReference>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009553">
        <property type="term" value="P:embryo sac development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF19">
        <property type="entry name" value="IMPORTIN-BETA DOMAIN, ARMADILLO-LIKE HELICAL, EXPORTIN-1_IMPORTIN-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118464" checksum="675AA466528EEEB8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K399</accession>
    <name>A0A118K399_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K399"/>
    <dbReference type="Gramene" id="KVI05595">
        <property type="protein sequence ID" value="KVI05595"/>
        <property type="gene ID" value="Ccrd_016081"/>
    </dbReference>
    <dbReference type="OMA" id="MSYFAWM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="48"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="389" mass="43547" checksum="D42D3026A59FC566" modified="2016-04-13" version="1">MSNDVENGQKSSVLPSAVIEPESTSKWHSAFLQQVSVYGIAAGYCLSASLLSIINKWAVMKFPYPGALTALQYFTSAAGVLLFGSLKLLEHDRLDLMTMWRFLPAAIIFYLSLFTNSELLLHANVDTFIVFRSAVPIFVAIGETLYLHQPWPSLKTWLSLATIFGGSVLYVITDYQFTFMAYSWAVAYLISMSIDFVYIKHVVMTIELNTWGLVLYNNLEALLLFPLELLIMGELKKIKHEMQDESDWYSFGVILPVGLSCLFGLAISFFGFSCRRAISATGFTVLGIVNKLLTVVINLMIWDKHSTFIGTIGLLICMFGGVMYQQSTSKKPKPANIKEVEAKENQDEEQQKLLELQNFTESSENDKQVTSSEEQNKVGGYYDGGHVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3A2</accession>
    <name>A0A118K3A2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3A2"/>
    <dbReference type="STRING" id="59895.A0A118K3A2"/>
    <dbReference type="Gramene" id="KVI05613">
        <property type="protein sequence ID" value="KVI05613"/>
        <property type="gene ID" value="Ccrd_016061"/>
    </dbReference>
    <dbReference type="OMA" id="ENWVGPR"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF56">
        <property type="entry name" value="ALA-INTERACTING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="37931" checksum="83906837DA0B9531" modified="2016-04-13" version="1">MEQKNKNSKKPSYSRFSQQELPAWKPILTPGWVIASFLTIGALFIPIGLVALSASDTVVEIIDRYDEDCVPDAYSKNPESFIQDPDIKKTCVRSLRVPKKMVAPIFVYYQLENFYQNHRRFVKSRSDKQLRDPEAKNDTYNCFPEARTADNKPIVPCGLIAWSLFNDTYKLSTRGKPITIDKKGIAWKSDTKVKFGSNVYPKDFQKGGLIGGAKLDEKVPLSEQEDLIVWMRTAALPNFRKLYGKIDIDLEAHETVKAEVENNYNTYKFGGRKKLVLSTTTWIGGKNDFLGVAYITVGGLCLFMAINFILLYVFRPRRLGDPSYLSWNRLPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3L0</accession>
    <name>A0A118K3L0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001851">
        <property type="protein sequence ID" value="KVI06090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3L0"/>
    <dbReference type="STRING" id="59895.A0A118K3L0"/>
    <dbReference type="Gramene" id="KVI06090">
        <property type="protein sequence ID" value="KVI06090"/>
        <property type="gene ID" value="Ccrd_015560"/>
    </dbReference>
    <dbReference type="OMA" id="TMINEAY"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="164" mass="18225" checksum="64DEE2EBD7F83B70" modified="2016-04-13" version="1">MASAAGIINGCVSSSSSSWGQLRNLHKKKAVNGGGGERRFRVRCVSTSPVASDPYKTLSIRPGASESEVKKAFRQLALKYHPDVCRGSNCGVQFHQINEAYDMVMNNLRDETSVSEMDVYGPSDAGIDEPMRGMDDPEWDMWEEWMGWEGAGIRDYTSHINPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K410</accession>
    <name>A0A118K410_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001619">
        <property type="protein sequence ID" value="KVI06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K410"/>
    <dbReference type="Gramene" id="KVI06793">
        <property type="protein sequence ID" value="KVI06793"/>
        <property type="gene ID" value="Ccrd_014854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="9966" checksum="C038F87158F4B125" modified="2016-04-13" version="1">MHVPALCRTSETFRFQRHRKAAVTSLLYSLTGKGARQGQRLSGCDAMSMALNRGVDATDDWLLPSADCHLLIVLESGNSVTVRSCQVGTVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4F8</accession>
    <name>A0A118K4F8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4F8"/>
    <dbReference type="STRING" id="59895.A0A118K4F8"/>
    <dbReference type="Gramene" id="KVI07468">
        <property type="protein sequence ID" value="KVI07468"/>
        <property type="gene ID" value="Ccrd_014158"/>
    </dbReference>
    <dbReference type="OMA" id="ECKEKLW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF3">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="280"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="478" mass="54059" checksum="02124912057EDD1E" modified="2016-04-13" version="1">MGSLTLTLACVPPKNPNCTATITRKNCVRNLTICSSYSIPVKFRRIKRIDIRLLACKCTSALSSSLISEPNWVRGDNKAEEDERVFIVVNFYRFVFIKDPEEEVSKHLEFLQGRDIHGRIYINEQGINAQYSGPSEDALAYVSWLKEDERFHDILVQISPPIRKHAFPRLKLRYKPSLMEGGVSHLPLIDSSMRATPLTPAEWRKRVEAANNIEVSSHLNPSRKVILLDVRNGKSVGNPNRISNDPKARMKLEPLLDQEREPPTKGVVTSNMSLFLLPGYEWDIGHFIGAQRPNVDCFRSTTFGLSGSEDVASDPLANVDKEKTDILMYCTGGIRCDVYSTILRQRGYKKLYTLRGGISHYLQCEGPVEWIGNLFVFDARLSLPPTSVKHDAKTDESLTHEVSDNTVFAKCYICGSQVSELRHRNCANLDCNLLFLCCSGCMDDLRGCCSSDCTSAARLRPVLPGHERYQKWHHYRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4K1</accession>
    <name>A0A118K4K1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcium-binding EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001498">
        <property type="protein sequence ID" value="KVI07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4K1"/>
    <dbReference type="STRING" id="59895.A0A118K4K1"/>
    <dbReference type="Gramene" id="KVI07663">
        <property type="protein sequence ID" value="KVI07663"/>
        <property type="gene ID" value="Ccrd_013969"/>
    </dbReference>
    <dbReference type="OMA" id="TNMNQQF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF137">
        <property type="entry name" value="CALCIUM-BINDING EF HAND FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="754"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="907"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="102372" checksum="FD4771E6648C968E" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4U6</accession>
    <name>A0A118K4U6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disease resistance protein At4g27190-like leucine-rich repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001314">
        <property type="protein sequence ID" value="KVI08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI08101">
        <property type="protein sequence ID" value="KVI08101"/>
        <property type="gene ID" value="Ccrd_013536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF198">
        <property type="entry name" value="RPP4C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="447"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="668"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="824"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1170" mass="133068" checksum="BB12EC6C321E68E4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5H4</accession>
    <name>A0A118K5H4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_012525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5H4"/>
    <dbReference type="Gramene" id="KVI09103">
        <property type="protein sequence ID" value="KVI09103"/>
        <property type="gene ID" value="Ccrd_012525"/>
    </dbReference>
    <dbReference type="OMA" id="YHVFIAY"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="13017" checksum="FF02B77A6B34C402" modified="2016-04-13" version="1">MASRRKINYTRLADEDNDYIGKEGYDPRFDYSPATLDEVPWKSIALALFLLFLGCGLLLLSFFIFTGHMGGDRSQAYGLLGLGVLTFLPGFYETRIAYYSWRGAQGYRYAAIPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5L2</accession>
    <name>A0A118K5L2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CarD-like/TRCF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K5L2"/>
    <dbReference type="Gramene" id="KVI09272">
        <property type="protein sequence ID" value="KVI09272"/>
        <property type="gene ID" value="Ccrd_012354"/>
    </dbReference>
    <dbReference type="OMA" id="MMELYIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="entry name" value="Transcription-repair-coupling factor, D7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_RID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_RID_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF29">
        <property type="entry name" value="TRANSCRIPTION-REPAIR-COUPLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_TRCF_RID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="CarD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="TRCF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="481"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="780" mass="87890" checksum="E8D740BA463026F1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L7</accession>
    <name>A0A118K6L7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_010712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000986">
        <property type="protein sequence ID" value="KVI10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L7"/>
    <dbReference type="STRING" id="59895.A0A118K6L7"/>
    <dbReference type="Gramene" id="KVI10891">
        <property type="protein sequence ID" value="KVI10891"/>
        <property type="gene ID" value="Ccrd_010712"/>
    </dbReference>
    <dbReference type="OMA" id="YPWIVFA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF83">
        <property type="entry name" value="SPHINGOLIPID TRANSPORTER SPINSTER HOMOLOG 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="49451" checksum="32EAAA8620A01153" modified="2016-04-13" version="1">MGVEAGSDTAVQDQESNPPAAAAAAAAVVVPVETESDMAKTSTSSSEPAPSWFTPKRLLVIFCVINMVNYVDRGAIASNGVNGSARVCTESGVCSHGSGIQGDFDLSNFKDGVISSAFMVGLLVASPIFASLAKRLVGVGEASFISLAAPFIDDNAPVTQVGNGLGWRYAFFGEAILMLPFAILGFVMKPLQMKGFSPAGSRKPFTTPETNVIEVEVITTDKDVPVLDRSSNKPSRSGLFRFWQDMKALLLEKIYVVNVLGYIAYNFVIGAYSYWGPKAGYSIYHMSNADLLFGGITIVGGIVGTLAGGIILDRMNSTIPNAFKLLSTTTFLGAIFCFSAFCFKNLYAFMVLFLIGEILVFATQGPVNFVCLHTVKPSLRPLSMAMSTVAIHVFGDVPSSPLVGIIQDNIDNWRTTALILTSILVDRYDEDKELPDATVERSNTTPLLEDETTETTAVSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB84</accession>
    <name>A0A124SB84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensitivity To Red Light Reduced-like, SRR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005133">
        <property type="protein sequence ID" value="KVH89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB84"/>
    <dbReference type="STRING" id="59895.A0A124SB84"/>
    <dbReference type="Gramene" id="KVH89847">
        <property type="protein sequence ID" value="KVH89847"/>
        <property type="gene ID" value="Ccrd_008153"/>
    </dbReference>
    <dbReference type="OMA" id="WRMDRLC"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="280" mass="32747" checksum="13DBF59B4FA07481" modified="2016-04-13" version="1">MAASAETLNCEQPKLVEDEWTIVLPRRSNQRRKFPKIKPAKQQELQTHWAPTDLETTPEKELQLMQKMQISIEKLEKSPFFCAFLDQIHTPEASECFHKITRSEHKLKMVIYGIGSIESFESPRLQLSLAILMKRKLDWIGDMEVFDPIISLTESKVLEEFGCRVLSVNEQGKRQAVNPILFFMPHCEAELYENLLKTNWRCDMLNQIVLLGNSFEKYEQHRSVFQNSALDDLRKHLLAVRPFTKEFEIRTVSDDYFRAFHGSSWHFFSVDSSTDLQLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBX0</accession>
    <name>A0A124SBX0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S59, nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004896">
        <property type="protein sequence ID" value="KVH91961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBX0"/>
    <dbReference type="STRING" id="59895.A0A124SBX0"/>
    <dbReference type="Gramene" id="KVH91961">
        <property type="protein sequence ID" value="KVH91961"/>
        <property type="gene ID" value="Ccrd_006007"/>
    </dbReference>
    <dbReference type="OMA" id="NTRHDED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="9">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="18917" checksum="9AB83B5E60D841AC" modified="2016-04-13" version="1">MTYRKERAEPGYYGRVKDFVVGHHGIGSIRFLGETDLRGVDLESFIGIIQGRVAYSVEKPLVGHGFNGTAEMTLVTLKFSYGKLVCRNTQKLINSKALSFRMQVENNGEEFVSYDPITGECKWRTNYFSGFGLIRFKAKGEFSAGDQEVDGEAEDTDQLVYMRFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCQ1</accession>
    <name>A0A124SCQ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Pectinesterase</fullName>
            <ecNumber evidence="2 8">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="2 8"/>
    <dbReference type="EMBL" id="LEKV01004551">
        <property type="protein sequence ID" value="KVH94482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCQ1"/>
    <dbReference type="STRING" id="59895.A0A124SCQ1"/>
    <dbReference type="Gramene" id="KVH94482">
        <property type="protein sequence ID" value="KVH94482"/>
        <property type="gene ID" value="Ccrd_003441"/>
    </dbReference>
    <dbReference type="OMA" id="RDCYIIG"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="46"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="389"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="701" mass="78247" checksum="070F8F616E6A4233" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDI3</accession>
    <name>A0A124SDI3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003874">
        <property type="protein sequence ID" value="KVH97046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDI3"/>
    <dbReference type="STRING" id="59895.A0A124SDI3"/>
    <dbReference type="Gramene" id="KVH97046">
        <property type="protein sequence ID" value="KVH97046"/>
        <property type="gene ID" value="Ccrd_000861"/>
    </dbReference>
    <dbReference type="OMA" id="RIAYMDI"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000003">
        <property type="entry name" value="GDSL esterase/lipase APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF3">
        <property type="entry name" value="OS09G0540400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176169" evidence="2">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="44068" checksum="537B9C15B29F59D5" modified="2016-04-13" version="1">MHANLTIFLSLLFLQVTTSTLLESPSKMTTPLARLNSSLKLNIPVFLLLVVFVSDAQPQNLVKKHHKVSAVLVFGDSTSDPGNNNYILTPFKGNFPPYGRDFADQKPTGRFSNGLLTSDFIARHVGVKDNVPAYLDPSLTIHDFMTGVSFASAGSGYDPLTPTISNVIPLPRQLEYFKEYKVKLVAAIGKKKTKEIINNALYLVSAGTNDFVVNYFTLPIRRHEYSLPSYMNFVMKTQLDFLQALWGEGARKIGVAGLPPMGCLPIVITLFSKNAIHDRGCIDFFSSVARTYNSMLQTQLNLMHFNHAHEGARIAYFDIYSPLLDGIVGHKYGFKEVRLGCCGTGLLETTFLCNPSSKTCSDASKYAFWDSIHPTQEMYKICSKALQPTIDHMIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE00</accession>
    <name>A0A124SE00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003787">
        <property type="protein sequence ID" value="KVH98587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE00"/>
    <dbReference type="STRING" id="59895.A0A124SE00"/>
    <dbReference type="Gramene" id="KVH98587">
        <property type="protein sequence ID" value="KVH98587"/>
        <property type="gene ID" value="Ccrd_023193"/>
    </dbReference>
    <dbReference type="OMA" id="EMAYEMW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF52">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DOG1" evidence="10">
        <location>
            <begin position="144"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="37761" checksum="6E99A3DE2E65F4B3" modified="2016-04-13" version="1">MASTSTQFATSRRMGIYDPLHHISMWDDTFGCDISPNTGPSTISQVDTRLAKTEYTSQESIGPSSDNQAAKNMSDKLQRRLAQNREAARKSRLRKKAYVQQLETGRLKLAQLEQELERARQQRVYGGLLNTSNGLLSGNVNSGIAAFEMAYEMWVSEQQKKDSELKDMLQTPMSDLELGIFVDSSLNHYYELFQMKANAAKSDVFYLMHGLWRTPVERFFQWLGGPRPSELLYILMPQFEPLTNAQIVSVSTLRHSCKQAEDALTLGMEKLQQTLAQGITIDITGAGSYNVLQQMSRILTTHQAARGLIALGEYFQRLRSLNSLWAARFREPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEU2</accession>
    <name>A0A124SEU2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003126">
        <property type="protein sequence ID" value="KVI01156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEU2"/>
    <dbReference type="STRING" id="59895.A0A124SEU2"/>
    <dbReference type="Gramene" id="KVI01156">
        <property type="protein sequence ID" value="KVI01156"/>
        <property type="gene ID" value="Ccrd_020583"/>
    </dbReference>
    <dbReference type="OMA" id="IQMVAKS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="5">
        <location>
            <begin position="113"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23506" checksum="FFE154747043529B" modified="2016-04-13" version="1">MSCPHISGVAALLKAAHPEWSPSAIKSALMTTAYTVDNLNSTLHDAAGGGLSTPWAHGAGHVEPHKAMSPGLVYDISTKEYIGLVCSLGYTMKQVAAVANVTSCTKRYRDPGQLNYPSFSIVFGKSSNSRVVRYTRKLTNVGAAKSVYKVAVDVPQGVEVSVKPRRLVFNKVGQRLRYTATFVSKNKNTRHGNSFGWISWKKGKKEVRSPIAFTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG25</accession>
    <name>A0A124SG25_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG25"/>
    <dbReference type="STRING" id="59895.A0A124SG25"/>
    <dbReference type="Gramene" id="KVI05058">
        <property type="protein sequence ID" value="KVI05058"/>
        <property type="gene ID" value="Ccrd_016618"/>
    </dbReference>
    <dbReference type="OMA" id="CIYEVYD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46635:SF2">
        <property type="entry name" value="GLYCOSYL TRANSFERASE FAMILY 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46635">
        <property type="entry name" value="GLYCOSYL TRANSFERASE FAMILY 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="411"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120168" checksum="F95558EBC9DDBC90" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGC0</accession>
    <name>A0A124SGC0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aminopeptidase</fullName>
            <ecNumber evidence="13">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_015789</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01001859">
        <property type="protein sequence ID" value="KVI05923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGC0"/>
    <dbReference type="STRING" id="59895.A0A124SGC0"/>
    <dbReference type="Gramene" id="KVI05923">
        <property type="protein sequence ID" value="KVI05923"/>
        <property type="gene ID" value="Ccrd_015789"/>
    </dbReference>
    <dbReference type="OMA" id="FIPCVDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF274">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="16">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="14">
        <location>
            <begin position="245"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="15">
        <location>
            <begin position="541"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="15">
        <location>
            <begin position="654"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI05923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="779" mass="89103" checksum="C280752AEA158C3F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGF6</accession>
    <name>A0A124SGF6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGF6"/>
    <dbReference type="Gramene" id="KVI06238">
        <property type="protein sequence ID" value="KVI06238"/>
        <property type="gene ID" value="Ccrd_015389"/>
    </dbReference>
    <dbReference type="OMA" id="DVQHANM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000660">
        <property type="entry name" value="RING/U-box superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315">
        <property type="entry name" value="RING FINGER PROTEIN 41, 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315:SF113">
        <property type="entry name" value="ZINC FINGER, RING_FYVE_PHD-TYPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="260" mass="29836" checksum="6DA144ED611DA616" modified="2016-04-13" version="1">MMDNYYYHQLASCPSYRDSLKVLEVDIQFANMLAASIPRDKGGACLRMELGYNDMAYILSFLLQWINFPCSCLLQTCLSFCYVIVHKVSIVLPDGRPKLTSLGRKASIREFYDVILPSLKRLRTNPLELDVSEGDIQAFGTIPKKKIEKRTNNSDVDMEREDECGICLEPCTKMVLPNCCHAMCINCYHDWNMRSVSCPFCRGSLKRVNSGDLWVLPCMGDVVDQKTVSKEDKKRFYNFINKLPKDIPDAVFLVYNDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHF5</accession>
    <name>A0A124SHF5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_012214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHF5"/>
    <dbReference type="STRING" id="59895.A0A124SHF5"/>
    <dbReference type="Gramene" id="KVI09388">
        <property type="protein sequence ID" value="KVI09388"/>
        <property type="gene ID" value="Ccrd_012214"/>
    </dbReference>
    <dbReference type="OMA" id="PFYVWDL"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051305">
        <property type="entry name" value="tRNA_2-thiouridylase_MnmA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052:SF1">
        <property type="entry name" value="TRNA-5-TAURINOMETHYLURIDINE 2-SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="377"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI09388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="509" mass="57809" checksum="3851C1F039AED29D" modified="2016-04-13" version="1">MLRTTMAALFHFHPTTMTTATATATIHSNGVLFRSLHKPLRFIIRKNYSRVVRPILSINIPRSLSSTAVPEISNNPIFYLDRDYLSCSMPNSNRPLKVAVLLSGGVDSSVALRLLHAAGHSCTAFYLKIWFQEDFENFWSECPWEEDLKYAKAVCNQVDVPLEVVHLTDEYWDKVVSYLIDEYKCGRTPNPDVLCNTRIKFGAFMDAISNMDFDFVASGHYAKVVHADSDKTNGISFLQLSKDMVKDQTYFLSYLSQAQLKRLVLPLGCIPKNDVRKLARKFDLPNQDRKDSQGICFLGKLKFSEFVGRHIGEREGIILEAETGDFLGAHRGFWFYTIGQRQGLGLAGGPWYVVEKDVKNNVVFVSRNYYSVDKRRRSFHVGSFRWISGSPPQNLNQLRCKVRHGPDFYDCTLHMEVAENRSESIGTVQLPKDDQGLAAGQFAAFYEEQVCVGSGVILESWDDKGFPVCDKAREIAKMEDKSKLGKPVKIMPKPEDVRKIPDRRCKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RG09</accession>
    <name>A0A103RG09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ORMDL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007812">
        <property type="protein sequence ID" value="KVG67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103RG09"/>
    <dbReference type="Gramene" id="KVG67135">
        <property type="protein sequence ID" value="KVG67135"/>
        <property type="gene ID" value="Ccrd_026277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVG67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="11023" checksum="679F2BFBFFADA082" modified="2016-04-13" version="1">MATICVPLMYNFNQVVTYHFFHWKKGTPFADDQGIYNRLTWWEQIDSGKQLTXNRKFLTVVLVVLVDVPTASNVYFTLGSISQTLDIKQFLTIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WLU2</accession>
    <name>A0A103WLU2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2R)-phospho-3-sulfolactate synthase, ComA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006521">
        <property type="protein sequence ID" value="KVH74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WLU2"/>
    <dbReference type="STRING" id="59895.A0A103WLU2"/>
    <dbReference type="Gramene" id="KVH74766">
        <property type="protein sequence ID" value="KVH74766"/>
        <property type="gene ID" value="Ccrd_025566"/>
    </dbReference>
    <dbReference type="OMA" id="KNQQVEF"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00945">
        <property type="entry name" value="Aldolase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="32545" checksum="EF98A33656F6A383" modified="2016-04-13" version="1">MADYRWKSFVEDEDRPEKPRRFGVTEIRGPNHTSLFSHTLLQDMLESMGQFVDGLKFTGGSESLMPKSFIREATKLAHEHNIYVSTGDWAEYLLQKGSSSFKEHIEECKQLGFDTVELNMGSLELPEETLLRYIRLIKSKGLKAKPQFAVKINKADIPPTHARAYGAHVVPTPRTSERVEDVDFLIRRAERCLEAGADMISIDAEDVCKYADSVRADIIAKVIGRLGLQKTMFEASNAKTSEWFIKQYGPNVNLFVDHSQVLDLECLRGRNLGKNHNSVLDSSYFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBF7</accession>
    <name>A0A103XBF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plus-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005997">
        <property type="protein sequence ID" value="KVH87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBF7"/>
    <dbReference type="STRING" id="59895.A0A103XBF7"/>
    <dbReference type="Gramene" id="KVH87629">
        <property type="protein sequence ID" value="KVH87629"/>
        <property type="gene ID" value="Ccrd_025087"/>
    </dbReference>
    <dbReference type="OMA" id="THWIPRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15568">
        <property type="entry name" value="PHD5_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045894">
        <property type="entry name" value="At5g08430-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058668">
        <property type="entry name" value="NERD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851">
        <property type="entry name" value="OS01G0884500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851:SF22">
        <property type="entry name" value="ZINC ION BINDING _ DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25980">
        <property type="entry name" value="NERD_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Plus3" evidence="5">
        <location>
            <begin position="372"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="526" mass="60596" checksum="B6828A54F8CBC02A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBG5</accession>
    <name>A0A103XBG5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005977">
        <property type="protein sequence ID" value="KVH87644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBG5"/>
    <dbReference type="Gramene" id="KVH87644">
        <property type="protein sequence ID" value="KVH87644"/>
        <property type="gene ID" value="Ccrd_025071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="31417" checksum="F4639C470AA53B99" modified="2016-04-13" version="1">MEILSESNISSENTEDKVGEGSVENCDAGVSKAKVEDICNAFEKLDVLVADEKANDVDENAIFLDTENLNGPSRMKLEDTSSGVSEMDDEILESNVDVVLVDFVEQEPNKAPAEESVIEKAIIDVMPTSTIDRDSEQVNQEAEQTMDYAEEITLASVADDSLIKEENQVPMKATDVIDHPTSIRKMTLDNNENIGSVVVAVEENKNINEQAVDEKPKSLNDTSIRQLKKQLKALSIKNNTNSIKDDKVGEVRPAMQAVCKNQLVTEEMEDGENMDGGDDSDIGGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD05</accession>
    <name>A0A103XD05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005388">
        <property type="protein sequence ID" value="KVH88523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD05"/>
    <dbReference type="STRING" id="59895.A0A103XD05"/>
    <dbReference type="Gramene" id="KVH88523">
        <property type="protein sequence ID" value="KVH88523"/>
        <property type="gene ID" value="Ccrd_026633"/>
    </dbReference>
    <dbReference type="OMA" id="IQQKNNC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH88523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="210" mass="23320" checksum="2B14B08D51954AD3" modified="2016-04-13" version="1">MGNVGVNQKSWNSQVPSFPSLLTLCDYLFKLLLIGDSSVGKSCLLLRFADDSYVDSYISTIGVDFKIRTVELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTEMESFNNVKQWLSEIDRYANESVCKLLVGNKCDLAFADELGIPFLETSAKDSVNVEQAFLTMAAEIKKKMGNQPTGDKKSGNTVQIKGKPIEQKSNCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF47</accession>
    <name>A0A103XF47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pistil-specific extensin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005205">
        <property type="protein sequence ID" value="KVH89528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF47"/>
    <dbReference type="STRING" id="59895.A0A103XF47"/>
    <dbReference type="Gramene" id="KVH89528">
        <property type="protein sequence ID" value="KVH89528"/>
        <property type="gene ID" value="Ccrd_008486"/>
    </dbReference>
    <dbReference type="OMA" id="PPTHYNH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003882">
        <property type="entry name" value="Pistil_extensin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33470">
        <property type="entry name" value="OS01G0164075 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33470:SF22">
        <property type="entry name" value="POLLEN OLE E 1 ALLERGEN AND EXTENSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01190">
        <property type="entry name" value="Pollen_Ole_e_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01218">
        <property type="entry name" value="PSTLEXTENSIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="256" mass="26926" checksum="B990929EC80E8623" modified="2016-04-13" version="1">MVLTSCFMVNVFGGDDLDLVSWTQAPHHAPSYPPVGAPPPHHHHKGPGGHHHKPAVPPTAHPPTVAPVHPPIKTPVAPPTKAPVAPPTKAPVAPPTKAPVAPPTKAPVKPPTKAPVKPPTKAPVHPPIHSPAPKHAPLPTRRQVAVRGAVVLLTCNNTKYPLRVKATTDKNGFFFIMPPKTLTTYGAHTCRVTLLSSPKATCNQPTNLHYGLKGATLVLTPKPHGSSLPAAPPLPFDVFTVGPFAFEASKKTPCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFJ7</accession>
    <name>A0A103XFJ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005135">
        <property type="protein sequence ID" value="KVH89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH89835">
        <property type="protein sequence ID" value="KVH89835"/>
        <property type="gene ID" value="Ccrd_008178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33484">
        <property type="entry name" value="BNAC07G33360D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33484:SF3">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="419" mass="47090" checksum="D1E9519B9DE30AD5" modified="2016-04-13" version="1">MSYHDSKSKPNLAKIGADAFALLDDFSGGNKSKPKPWLSKVSAPPRRTPNKLFHYQYQPKEAYVIQQVYVAPVEEMRIETVVDCYEAAKSPRLQMMRIEKAADCCEEAKMYGGTVILDYTQSKPVRNGPELAKIGANAFTLLDDFSCGHKRTRGLEKVVHCILLERDEALEEGHDVVPRRRTEAVQLLAVTIWERVRSGDSEIAKASRPELAKIGADAFTLLDDFSCGHKYKPKPSSSNISTSPVQPLDELSHYQYQRXQAYVVRQQVYVAPIHATRIETVVDCYEAAKKYGGTFKMSYHDSKSKPNLAKIGADAFALLDDFSGGNKSKPKPWLSKVSAPPRRTPNKLFHDLYQPKNASVIQEEVYDAPVEEMIKTAVDCYKADKRYGGTVTLDYPKRKPARKGVDKVCNSNNVYLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFY9</accession>
    <name>A0A103XFY9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_008017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005120">
        <property type="protein sequence ID" value="KVH89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFY9"/>
    <dbReference type="STRING" id="59895.A0A103XFY9"/>
    <dbReference type="Gramene" id="KVH89971">
        <property type="protein sequence ID" value="KVH89971"/>
        <property type="gene ID" value="Ccrd_008017"/>
    </dbReference>
    <dbReference type="OMA" id="DKMPQIK"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000019">
        <property type="entry name" value="polygalacturonase At1g48100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118754" evidence="10">
        <location>
            <begin position="31"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="501" mass="53787" checksum="27827422B8C726C3" modified="2016-04-13" version="1">MSCSSFRSFTLTILIAILVWSSATHHTCNARRGRHWRNPSSSLSKKKSGNHHHNGGGGGGAGKSKSKSKSSSHSHKTPPSKDADTYNVLNFGAKGDGTSDDTKAFEGAWAAACKVKGSKIIVPSPYKFLVGPITFSGPYCQQNIIFQVDGTIIAPSNFKSYGSGLFQWILFTKLVGLTIQGGGTIDGSGSIWWKDFPANDPFDDQLKLIAPTNGTINQTSHSSISDSLGGKMPSIKPTALRFYGSFDVTVTGIKIQNSPQCHLKFDNCVGVSVYDFSVSSPADSPNTDGIHLQNSKDVLIHTTDLSCGDDCVSIQTGCSNIYIHNVNCGPGHGISIGGLGKENTKACVSNVTVRDVVMHNTMNGVRIKTWQGGSGSVQGVMFSNIQVSEVQLPIVIDQFYCDKTTCKNQSSAVALSGITYERIKGTYTVKPVHFACSDSMPCTDVNLNGINLKPVQERYHLYDPFCWKTFGELVSPAVPPVECLQIGKPSSSHVQADHDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGU9</accession>
    <name>A0A103XGU9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA glycosylase family. DEMETER subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH90464">
        <property type="protein sequence ID" value="KVH90464"/>
        <property type="gene ID" value="Ccrd_007522"/>
    </dbReference>
    <dbReference type="OMA" id="TWNSISC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035514">
        <property type="term" value="F:DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141166">
        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000004">
        <property type="entry name" value="DNA glycosylase/AP lyase ROS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044811">
        <property type="entry name" value="DME/ROS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028924">
        <property type="entry name" value="Perm-CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028925">
        <property type="entry name" value="RRM_DME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46213:SF13">
        <property type="entry name" value="DEMETER-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46213">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR DEMETER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15629">
        <property type="entry name" value="Perm-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15628">
        <property type="entry name" value="RRM_DME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="884"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1747" mass="194893" checksum="9C23BA30B4E17FC7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGY1</accession>
    <name>A0A103XGY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_007401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGY1"/>
    <dbReference type="STRING" id="59895.A0A103XGY1"/>
    <dbReference type="Gramene" id="KVH90568">
        <property type="protein sequence ID" value="KVH90568"/>
        <property type="gene ID" value="Ccrd_007401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH90568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12026" checksum="F0A0B2F3393BB95E" modified="2016-04-13" version="1">MEEGWMRRSAMVVKGSIMGLGGAGRRQWWLRKKTIGRRVVVNPAVTIKVIGHQRYQSAPLHEGDLSATKCLKNMVPEASGLPVISYSRSNIRSGHYQLNNRPKKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHV3</accession>
    <name>A0A103XHV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHV3"/>
    <dbReference type="STRING" id="59895.A0A103XHV3"/>
    <dbReference type="Gramene" id="KVH91010">
        <property type="protein sequence ID" value="KVH91010"/>
        <property type="gene ID" value="Ccrd_006950"/>
    </dbReference>
    <dbReference type="OMA" id="DNRVSWF"/>
    <dbReference type="OrthoDB" id="1920857at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31722:SF2">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31722">
        <property type="entry name" value="OS06G0675200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="210" mass="23662" checksum="794A46E71A0D1EAD" modified="2016-04-13" version="1">MVSLETTPPPPPPATASPRISFSGDFLDDANFICITPQDKEKEIKTRTGEFEFLSGDLSSPATMLTADELFFEGKLLPFWQNEKLNKINIKPEKVVAKEAVTMKEDENNNNNKMSWFIDEDPSPRPPKCTVLWKELLRLKKQRTSSVLSPSSSTSSNSSSNSIDDQDSSKKEKQQQVKRIKQGLERTRSSGIKIRPMINPVNLISRFSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI90</accession>
    <name>A0A103XI90_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005067">
        <property type="protein sequence ID" value="KVH91230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI90"/>
    <dbReference type="STRING" id="59895.A0A103XI90"/>
    <dbReference type="Gramene" id="KVH91230">
        <property type="protein sequence ID" value="KVH91230"/>
        <property type="gene ID" value="Ccrd_006759"/>
    </dbReference>
    <dbReference type="OMA" id="DIICERG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="768" mass="86875" checksum="D68E3A2BB2B0D7A6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XID3</accession>
    <name>A0A103XID3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The PPC domain mediates interactions between AHL proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005070">
        <property type="protein sequence ID" value="KVH91193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XID3"/>
    <dbReference type="STRING" id="59895.A0A103XID3"/>
    <dbReference type="Gramene" id="KVH91193">
        <property type="protein sequence ID" value="KVH91193"/>
        <property type="gene ID" value="Ccrd_006791"/>
    </dbReference>
    <dbReference type="OMA" id="HAYVIEE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039605">
        <property type="entry name" value="AHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500:SF96">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="6">
        <location>
            <begin position="94"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="310" mass="32197" checksum="CC17D23404EEB2F0" modified="2016-04-13" version="1">MESRENMTPAVETIAPEAPSSYQLAQRTDSPTAQIGNPSQTMGPLGFSPVAGGMPSSLAKKKRGRPRKYGPDGVGASGGASGRTLSPMPLSAASSPPTSGGYSDIKFGEPTGSGGEFQVEKKKKRKINSLEAKSNMSPDDRITSGGSFTPHMVTVNPGEGRFEILSLSGSFTPGEVGGLSSREGGMSIALSSPDGRVVGGLLGGLLTAAGPVQVVVASFLPEIGTPAGPKPKKKKDAIKLLTPVADPTTVPRTTNTDHQNFNDKSQESPAKGNTNSTPASNFQHENRSTGPNVHDWRRAATDMNVSLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIZ3</accession>
    <name>A0A103XIZ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004916">
        <property type="protein sequence ID" value="KVH91608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIZ3"/>
    <dbReference type="STRING" id="59895.A0A103XIZ3"/>
    <dbReference type="Gramene" id="KVH91608">
        <property type="protein sequence ID" value="KVH91608"/>
        <property type="gene ID" value="Ccrd_006367"/>
    </dbReference>
    <dbReference type="OMA" id="VYTYGVM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF22">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="661"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="92790" checksum="F3882E8D1FFF3735" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJE7</accession>
    <name>A0A103XJE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJE7"/>
    <dbReference type="STRING" id="59895.A0A103XJE7"/>
    <dbReference type="Gramene" id="KVH91863">
        <property type="protein sequence ID" value="KVH91863"/>
        <property type="gene ID" value="Ccrd_006094"/>
    </dbReference>
    <dbReference type="OMA" id="HCEIRWE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010162">
        <property type="term" value="P:seed dormancy process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF878">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN TYROSINE KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="368"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="657" mass="73783" checksum="1DEA4B7D74AAA048" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJI9</accession>
    <name>A0A103XJI9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-like helical</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004897">
        <property type="protein sequence ID" value="KVH91951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJI9"/>
    <dbReference type="STRING" id="59895.A0A103XJI9"/>
    <dbReference type="Gramene" id="KVH91951">
        <property type="protein sequence ID" value="KVH91951"/>
        <property type="gene ID" value="Ccrd_006038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7233" checksum="F2054DE4EF99C269" modified="2016-04-13" version="1">MRDYRLVLLVQMSAELLKDRLPEAREATRSIVLLIYSAVMEEEDESKEEEKQQEKWQKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJL2</accession>
    <name>A0A103XJL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004895">
        <property type="protein sequence ID" value="KVH91968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJL2"/>
    <dbReference type="STRING" id="59895.A0A103XJL2"/>
    <dbReference type="Gramene" id="KVH91968">
        <property type="protein sequence ID" value="KVH91968"/>
        <property type="gene ID" value="Ccrd_005995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="690239at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012511">
        <property type="term" value="C:monolayer-surrounded lipid storage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000136">
        <property type="entry name" value="Oleosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01277">
        <property type="entry name" value="Oleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH91968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="170" mass="18021" checksum="76EB75B020A46193" modified="2016-04-13" version="1">MAENNPQLSDQLTKLAKVAAVGGLLLVFSPMLLIFSPVLVPAYIMYWIYRYVTGKHPIGSDQVAKAQEKITDAAADVKDKVVQAGEKIVDTVEDLAKNNIVTKSAEKIVDTADDLAKNNIITESAEKIVDTAEDLVKDGVSQAGELVGGVKNTVENLGKDILKLGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJT8</accession>
    <name>A0A103XJT8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Parallel beta-helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004858">
        <property type="protein sequence ID" value="KVH92088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJT8"/>
    <dbReference type="STRING" id="59895.A0A103XJT8"/>
    <dbReference type="Gramene" id="KVH92088">
        <property type="protein sequence ID" value="KVH92088"/>
        <property type="gene ID" value="Ccrd_005882"/>
    </dbReference>
    <dbReference type="OMA" id="CYISHFK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF7">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118848" evidence="2">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="46280" checksum="E75FE4BC04CCCC2D" modified="2016-04-13" version="1">MGVFSFHKMMVVLGLLACFIMANHVEIGHSLHVERLASGGARDRDSHVRKLQEFKSYFFRREHTTVSLSSSSSPSPSPSPSSPGRTGSGVFPVTAYGADPTGKTDSTDAILEAISDAVSGNGDGYEFITLRDLMVDCNFKGGGIRLIDALRTTIDNCYVAHFTTTGILVQGGHETYIRNSFLGQHITAGGDPHERNFTGTAIDLQGNDNAVTDVVIFSAEVGIAISGQANMITGVHCYNKANGFGGIGILLKVPGITQTRIVNSYFDYTGIVAEDPVQLHISDCFFLGDSFIVLKSVRGVVNGINIINNMFSGSNKGIDIVQLDQTNEEFKEIGHVVVDKNNVNGMNLKATIAKGVTRVNGTSWIVDFNEILLFPRRIRFVQHALLTGASNSFPNTVLRNISNNQVLIESDTIVEGSVSVSVDQSPSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKY1</accession>
    <name>A0A103XKY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004811">
        <property type="protein sequence ID" value="KVH92627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKY1"/>
    <dbReference type="Gramene" id="KVH92627">
        <property type="protein sequence ID" value="KVH92627"/>
        <property type="gene ID" value="Ccrd_005309"/>
    </dbReference>
    <dbReference type="OMA" id="PEMYMSP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36747">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36747:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="9932" checksum="D4E7D41D842F88FE" modified="2016-04-13" version="1">MDQTSPKSPPPQQPPPPPPPLNSLVPATVAPTPLIVPKAFKYPEMYMSPTDLIMSPVTKGILARTRSNKFKFQNLKKWVLLKFDGLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLE6</accession>
    <name>A0A103XLE6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLE6"/>
    <dbReference type="STRING" id="59895.A0A103XLE6"/>
    <dbReference type="Gramene" id="KVH92883">
        <property type="protein sequence ID" value="KVH92883"/>
        <property type="gene ID" value="Ccrd_005163"/>
    </dbReference>
    <dbReference type="OMA" id="NIALGPP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030380">
        <property type="entry name" value="SAM_MeTfrase_DRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF25">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51680">
        <property type="entry name" value="SAM_MT_DRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase DRM-type" evidence="11">
        <location>
            <begin position="277"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="599" mass="67353" checksum="5E34121C249C4CB2" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN09</accession>
    <name>A0A103XN09_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ccrd_004252</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004628">
        <property type="protein sequence ID" value="KVH93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN09"/>
    <dbReference type="Gramene" id="KVH93695">
        <property type="protein sequence ID" value="KVH93695"/>
        <property type="gene ID" value="Ccrd_004252"/>
    </dbReference>
    <dbReference type="OMA" id="NPLICRN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000016">
        <property type="entry name" value="Somatic embryogenesis receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="387"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KVH93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="736" mass="81327" checksum="D1ADCF8A1ADAC817" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN39</accession>
    <name>A0A103XN39_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CTLH, C-terminal LisH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004599">
        <property type="protein sequence ID" value="KVH93799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN39"/>
    <dbReference type="STRING" id="59895.A0A103XN39"/>
    <dbReference type="Gramene" id="KVH93799">
        <property type="protein sequence ID" value="KVH93799"/>
        <property type="gene ID" value="Ccrd_004144"/>
    </dbReference>
    <dbReference type="OMA" id="VPKTGGF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010072">
        <property type="term" value="P:primary shoot apical meristem specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000558">
        <property type="entry name" value="Topless-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000479">
        <property type="entry name" value="Topless-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048419">
        <property type="entry name" value="Topless_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF35">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21359">
        <property type="entry name" value="zf_topless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="457"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="930"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126009" checksum="AF1F29CBBAA65705" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN68</accession>
    <name>A0A103XN68_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004585">
        <property type="protein sequence ID" value="KVH93916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN68"/>
    <dbReference type="Gramene" id="KVH93916">
        <property type="protein sequence ID" value="KVH93916"/>
        <property type="gene ID" value="Ccrd_004005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13703" checksum="84103B14271ED4A7" modified="2016-04-13" version="1" fragment="single">KGKGKGKGKGKRKRKRVTAPLGKAKASLSLSLSLQSRSIFSSQSPHSSLSLRLLDNLQGHRQQINDLMGYIIVISLPVILLFLIIAIGCYLFGKNRGRSEATTTQYYGPPAPPYGVQPQATPINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP62</accession>
    <name>A0A103XP62_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="Ccrd_003530"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ACDP"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="614" mass="67609" checksum="34F7E82AE8B8648B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="synonym">Cynara scolymus</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
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            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="790"/>
        </location>
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            <end position="966"/>
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            <end position="124"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1073" mass="121345" checksum="59F8BFB3BB0CB0CC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
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            <taxon>Carduinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
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                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="EnsemblPlants"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSD5</accession>
    <name>A0A103XSD5_CYNCS</name>
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        <submittedName>
            <fullName evidence="3">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
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        <dbReference type="NCBI Taxonomy" id="59895"/>
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            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
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            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
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                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004364">
        <property type="protein sequence ID" value="KVH96023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSD5"/>
    <dbReference type="Gramene" id="KVH96023">
        <property type="protein sequence ID" value="KVH96023"/>
        <property type="gene ID" value="Ccrd_001895"/>
    </dbReference>
    <dbReference type="OMA" id="CCSEAYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000001">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119052" evidence="2">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="30974" checksum="BF661DA82708894C" modified="2016-04-13" version="1">MDRHRHPIILTLIFTFSVISVVQSTSFKIVNRCRHTVWPGILTGAGRTVLNPTGFTLKPGKSRTLRVPVAWSGRLWGRTDCQIDSTGKLACVTADCGSGRVECEGRGAEPPATLAEFTLNGDQGLDFYDVSLVDGYNLPMLVIPRDGTSGGCSSTGCLVDLNGGCPTALRVARSSRSGSVVACKSACEAFGDPRYCCSEGYNTPETCPPTEYSEYFKHVCPRSYSYAYDDKTSTFTCAGADYVIIFCPSPYTSEKLLEARKEVADLPLVNKTMMYIGRHHGGGVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSI5</accession>
    <name>A0A103XSI5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 16">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="16">GNT-I</shortName>
            <shortName evidence="16">GlcNAc-T I</shortName>
            <ecNumber evidence="13 16">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_001861</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="16">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus membrane</location>
            <topology evidence="1 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13 16"/>
    <dbReference type="EMBL" id="LEKV01004362">
        <property type="protein sequence ID" value="KVH96073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSI5"/>
    <dbReference type="STRING" id="59895.A0A103XSI5"/>
    <dbReference type="Gramene" id="KVH96073">
        <property type="protein sequence ID" value="KVH96073"/>
        <property type="gene ID" value="Ccrd_001861"/>
    </dbReference>
    <dbReference type="OMA" id="SHLVEYR"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.20:FF:000002">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000090">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH96073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="371" mass="43394" checksum="3F638BE5076C2E97" modified="2016-04-13" version="1">MNEMRLLIDQISMHQENIVFLEEKVKRKEHECEQLRTVVQDLEKKAVGSLIREAEVPVAAVVIMACNRADYLERTIKSILKYHSSVALKFPVFVSQDGSNSDVRTMAMGYDQLTYMQHLDYEPVHMERPEELIAYYKIARHYKWALDQLFYKHNFNRVIILEDDMEISPDFFEYFEAGADLLDKDKSIMAISSWNDNGQKQFVHDPYTLYRSDFFPGLGWMLTKPTWDELSPKWPKAYPFQQGSSLGQFFQQYLKPIKLNDIQVDWKSMNLSYLMEDKFVKYFADLVKNAKPLDGTDLVSKTNNVDGDVRIQYRDQSHFENIAHQYGIFDEWKDGIPRTAYKGVVVFRHQTLKCVFIVGPDSLQQLGIQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTM3</accession>
    <name>A0A103XTM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme, E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004255">
        <property type="protein sequence ID" value="KVH96668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTM3"/>
    <dbReference type="STRING" id="59895.A0A103XTM3"/>
    <dbReference type="Gramene" id="KVH96668">
        <property type="protein sequence ID" value="KVH96668"/>
        <property type="gene ID" value="Ccrd_001242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF18">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 38 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="163"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="303" mass="33460" checksum="9D76FBBACED647C5" modified="2016-04-13" version="1" fragment="single">GSCLKTARIEEPSRTAKHTLHFCFLSGFDSIRSLSAGMEVGIEGLDSDVSILKKVKHDEDPVPSTSMTASLSNLAPMVPQVLSTGAEILENPCLPMNKGKDVASSSSTVHQNPVPSSAKNKEEVAENELKKKFEEFKLFDTVDDVSDHHFNCAGFQGQQPSRSWTKKIQDEWKILEKDLPDTIFVRAYETRMDLLRAVIIGPAGTPYHDGLFVFDVHFPPNYPDIPPHFEDLVGGHFRSRAHCILLACKAYMEGAPVGSITDEKIPNEKSGSKSFKAAVAKLMNGLISNFSRYGVTNCDQYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUE4</accession>
    <name>A0A103XUE4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003866">
        <property type="protein sequence ID" value="KVH97054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUE4"/>
    <dbReference type="Gramene" id="KVH97054">
        <property type="protein sequence ID" value="KVH97054"/>
        <property type="gene ID" value="Ccrd_000849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13186" checksum="31963204851C0638" modified="2016-04-13" version="1">MVRTLGVKIHHLFQRVQLMYHQLIPLQMDRVSIVGDAIEYIKELETNVQDELKRLEDNDSKSHEDEVEVCKPKRGNAILSPDQRLEKRGITTMSWLRFQSRFVPADLGSLELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUF7</accession>
    <name>A0A103XUF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_000818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003862">
        <property type="protein sequence ID" value="KVH97086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUF7"/>
    <dbReference type="STRING" id="59895.A0A103XUF7"/>
    <dbReference type="Gramene" id="KVH97086">
        <property type="protein sequence ID" value="KVH97086"/>
        <property type="gene ID" value="Ccrd_000818"/>
    </dbReference>
    <dbReference type="OMA" id="AYQRQYK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF41">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="187"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="288"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH97086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="41877" checksum="71A53B854F6CE30F" modified="2016-04-13" version="1">MIDQAQHPSVSQKLAGSLLGSNMMQFHACETGLQQPHLYRRHFGNESHTDSAFRYPMKPSSSICIQAPSEKGFAGFAIDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKAGRLSEPYKGIGDCFGRTIKEEGLVSLWRGNTANVIRYFPTQASNLQILIALNFAFKDYFKRLFNFKKDRDGYWKWFAGNLASGGAAGASSLFFVYSLDYARTRLANDAKAAKKGGGGRQFNGLIDVYKKTLATDGIAGLYRGFNISCVGIIVYRGLYFGLYDSLKPVILVGDLQDSFFASFALGWVITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSMDAFTQILKNEGAKSLFKGAGANILRAIAGAGVLSGYDKLQLLIFGKKYGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUS5</accession>
    <name>A0A103XUS5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUS5"/>
    <dbReference type="Gramene" id="KVH97243">
        <property type="protein sequence ID" value="KVH97243"/>
        <property type="gene ID" value="Ccrd_000627"/>
    </dbReference>
    <dbReference type="OMA" id="YICFRHR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044289">
        <property type="entry name" value="ATL67-70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46592">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46592:SF6">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="243" mass="27275" checksum="4041F3D55DAC6761" modified="2016-04-13" version="1">MSTTTTIPFPSPPPPPLSSATHYYITNLGLGYAIAIAFGFLVLFSSLLLASYICFRHRHSHRRQIRNPNGGGSDNGVMVPSIIFVGEDNNDDQNVVIGLDQSVINSYPKFLFTRGIPKAIDSVCAICLCEYREAEMMRMLPDCKHCFHLTCVDAWLKLNATCPVCRSSPLPTPLSTPLAEVVPLSQYSDGRRRSLQHLNKMHSFRSGDLLAHNRRCTLVKSWLDLQFVRNWCAGAYPQERFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV92</accession>
    <name>A0A103XV92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV92"/>
    <dbReference type="Gramene" id="KVH97470">
        <property type="protein sequence ID" value="KVH97470"/>
        <property type="gene ID" value="Ccrd_000444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="118" mass="12372" checksum="2A5EEC71DE168D5E" modified="2016-04-13" version="1">MHRSYLISKTPFMVSSFIKNLSGLNSIGSSHTFGSQPISATKKLMVAPSGILYPSTSTSFVTLCGSRRWPDGCLLSPSKTTAFRYGIFCRSSSFITDSSSTPGDGGGGGGPTTEMISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVL8</accession>
    <name>A0A103XVL8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ninja-family protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ABI-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a negative regulator of abscisic acid (ABA) response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Ninja family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVL8"/>
    <dbReference type="STRING" id="59895.A0A103XVL8"/>
    <dbReference type="Gramene" id="KVH97713">
        <property type="protein sequence ID" value="KVH97713"/>
        <property type="gene ID" value="Ccrd_000185"/>
    </dbReference>
    <dbReference type="OMA" id="CACHCDI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031307">
        <property type="entry name" value="Ninja_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012463">
        <property type="entry name" value="Ninja_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032310">
        <property type="entry name" value="NLS_NINJA_AFP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31413">
        <property type="entry name" value="AFP HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31413:SF46">
        <property type="entry name" value="NINJA-FAMILY PROTEIN AFP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07897">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16136">
        <property type="entry name" value="NLS_NINJA_AFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ethylene-responsive binding factor-associated repression" evidence="6">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Tify" evidence="7">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="36774" checksum="B6EFD248ED97F167" modified="2016-04-13" version="1">MGDRTSNEMENLSLQMKKRFSRDLLQRFRVNTTSTGDPIGSDPGEDTSDEIELNLGLSLGGRFGVDKSNSKLVRSSSIAAILPVVKDDDVLGVSQGKTGPGGSYSGLIRTSSLPVETEEERRKRKELQSLRRLAAKRRRSEKQRNLTKVERDEYVAAMGRVGSSVGPSLGSGNWDFGDVEGLIGKGGTMNNGSGGGATSDGSGGGLTQPSLPGSVESQASSMSEFESRHFQEGSKQDDSRSKVVNPAVQTSRPKTENPSNNKGKEMRSNMVDMPCVFTQGDSPSGRRIEGILYKYGKGEEVKIMCVCHGSFLSPAEFVKHAGGTDVLHPLKHIVVNPNSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVR1</accession>
    <name>A0A103XVR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVR1"/>
    <dbReference type="STRING" id="59895.A0A103XVR1"/>
    <dbReference type="Gramene" id="KVH97778">
        <property type="protein sequence ID" value="KVH97778"/>
        <property type="gene ID" value="Ccrd_000101"/>
    </dbReference>
    <dbReference type="OMA" id="FEGELYC"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20170" checksum="F204F2907300FE0F" modified="2016-04-13" version="1">MAMDGSSGGDEFAVGCLLSIKTTLGDEFEGQVITYDRPSNIVVLQEGLKSNPQSRRSIRFLKANYIKEFSFLGQSDDPLDLKKCYLDLNSLQSKEEAAVRQAEIDVERIGVGVTAEAQSIFDALSKTLPVRWDKTAIVVMNEVRVSSPYLAESVTGGTPAANERVRKVLELERRRLQTRGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWS5</accession>
    <name>A0A103XWS5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein beta WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003803">
        <property type="protein sequence ID" value="KVH98295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWS5"/>
    <dbReference type="STRING" id="59895.A0A103XWS5"/>
    <dbReference type="Gramene" id="KVH98295">
        <property type="protein sequence ID" value="KVH98295"/>
        <property type="gene ID" value="Ccrd_023485"/>
    </dbReference>
    <dbReference type="OMA" id="VNFLIWR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000218">
        <property type="entry name" value="WD40 repeat-containing protein HOS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="458"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="583"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="701" mass="80076" checksum="74FECBF668C7F70E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXI0</accession>
    <name>A0A103XXI0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHD-type zinc finger plants domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003768">
        <property type="protein sequence ID" value="KVH98674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXI0"/>
    <dbReference type="STRING" id="59895.A0A103XXI0"/>
    <dbReference type="Gramene" id="KVH98674">
        <property type="protein sequence ID" value="KVH98674"/>
        <property type="gene ID" value="Ccrd_023100"/>
    </dbReference>
    <dbReference type="OMA" id="SYELFQC"/>
    <dbReference type="OrthoDB" id="1935489at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056874">
        <property type="entry name" value="PHD_dom_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33779">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33779:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25054">
        <property type="entry name" value="PHD_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHD-type zinc finger plants" evidence="2">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="210" mass="22947" checksum="C25D2D86D2010A96" modified="2016-04-13" version="1">MMASKGGGGGGVPNIIQPISSAECCMCGDYGLSEELFRCKICKFRSQHKYCSNQYPKAESYKACNWCLTQKHDSGNSSNSSSSCRNNSGDDRRDHIAVKNKRNPNDRIGHGGLRERRRASEIQLTNTAPIKKLHGSSAEEESPVSTGRKRFGGGVVEKKNHVVLRKSKSANHISHSHGDGGGGGGGGIKTRQVFRNKVRRYKLLDEVSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXX5</accession>
    <name>A0A103XXX5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003650">
        <property type="protein sequence ID" value="KVH98836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXX5"/>
    <dbReference type="STRING" id="59895.A0A103XXX5"/>
    <dbReference type="Gramene" id="KVH98836">
        <property type="protein sequence ID" value="KVH98836"/>
        <property type="gene ID" value="Ccrd_022935"/>
    </dbReference>
    <dbReference type="OMA" id="KECEYMC"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20543">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000034">
        <property type="entry name" value="D2/4-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000040">
        <property type="entry name" value="D6-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="39217" checksum="D68C7A3F456DAF50" modified="2016-04-13" version="1">MAPSLDCAMSSLLCAEDNDSICYNDNDGDDFKGFGDSFSNDGIDRNINQTQNHNLVKNLETEYSVLDLPLQNDECLTLLIEKESQQFVGFVDYLNKLKNENLFLVARQQAVDWISKVHAQFNFGPLCAYLSVNYLDRFLAVYELPKDKAWMMQLLAVTCLSLAAKMEETEMPLNLDLQAGESRYVFESKTIQRMELVVLNTLNWRMQSVTPFSFIDSFIGKLNDEDHGDDNGQSQTNSRSLIFKSTTQLVLSLIRGIEFLEFRPSEVAAAVAISVVGIGVEKLETSAIFQHANKERVLKCAEMMKKGCTMGFRSGKMTSLPESPIGVLEAAILSYKTDDSPTCAKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYA7</accession>
    <name>A0A103XYA7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAG1At protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYA7"/>
    <dbReference type="STRING" id="59895.A0A103XYA7"/>
    <dbReference type="Gramene" id="KVH99045">
        <property type="protein sequence ID" value="KVH99045"/>
        <property type="gene ID" value="Ccrd_022721"/>
    </dbReference>
    <dbReference type="OMA" id="FLMNRGT"/>
    <dbReference type="OrthoDB" id="1881135at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35990">
        <property type="entry name" value="GAG1AT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35990:SF1">
        <property type="entry name" value="GAG1AT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8659" checksum="8545180B32F71CDF" modified="2016-04-13" version="1">MGSQTNNGGGGFRAKMEHYLYSGEKKHVMAGMAIIGVIFGVPWYLMNRGTKHQSHQDYLEKADRARNARLHSAPSAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y020</accession>
    <name>A0A103Y020_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Syntaxin/epimorphin, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y020"/>
    <dbReference type="STRING" id="59895.A0A103Y020"/>
    <dbReference type="Gramene" id="KVI00040">
        <property type="protein sequence ID" value="KVI00040"/>
        <property type="gene ID" value="Ccrd_021692"/>
    </dbReference>
    <dbReference type="OMA" id="FQAAVCH"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000003">
        <property type="entry name" value="Qa-SNARE, Sso1/Syntaxin1-type, SYP12A-group"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000008">
        <property type="entry name" value="Syntaxin 132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF300">
        <property type="entry name" value="SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="295" mass="33394" checksum="EDC241BAD2A0E9BA" modified="2016-04-13" version="1">MNDLLSRSFSGGRNGDIEMGNATDGDGTNLDKFFKDVEAIKEELKALELLHDQLQSSNEQSKTLHSANSIKTLRTKMDNDVAMSLKKAKLIKNNLEALDRSNANNRNLPGCGPGSSTDRTRTSVVNGLRKQLQSSMKSFNELRQKMSVEHRETVQRRYYTVTGENPDEATVDNLISTGQSETFLQKAIQEQGRGQVMETVLEIQERHDAVTVIERNLKELHQVFMDMAVLVEHQGEQLDDIESHVNRANSYVTRGTNQLVEARKKQKNTRKWTCFAILLLLIIIAIIVLSIRPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1J8</accession>
    <name>A0A103Y1J8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003219">
        <property type="protein sequence ID" value="KVI00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1J8"/>
    <dbReference type="STRING" id="59895.A0A103Y1J8"/>
    <dbReference type="Gramene" id="KVI00832">
        <property type="protein sequence ID" value="KVI00832"/>
        <property type="gene ID" value="Ccrd_020913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="15449" checksum="201D5C10FDCE42BD" modified="2016-04-13" version="1" fragment="single">MENPQSNKRRLVQMQLHAKILTAHRAFFDVAVEVDSLTDQVAEVQRTTLVELLRRQAVKLDAITAQGDTSAEKILQAIQGFAEPYWTKALSCRWLRRAGKKIKTLPPKAESSYSSVIVDDDGTKSRDLSHPLFISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1K5</accession>
    <name>A0A103Y1K5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003212">
        <property type="protein sequence ID" value="KVI00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1K5"/>
    <dbReference type="STRING" id="59895.A0A103Y1K5"/>
    <dbReference type="Gramene" id="KVI00854">
        <property type="protein sequence ID" value="KVI00854"/>
        <property type="gene ID" value="Ccrd_020890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="76"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17100" checksum="EE61DDBF8420380C" modified="2016-04-13" version="1">MGGKGVFPPTTHLPTSCQITFPTSYSSSSRRWHSPLPISAASPPWTPYRLHLPISPSISIQSPPPQPPEYIQQQQLKNIIDTLIGAGDFTAWANILFNPNTNSSIPTTTTATLIPTTATMFVPGNDALTHLSATATGAYNFDPFIIPYHILPQRLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2A5</accession>
    <name>A0A103Y2A5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2A5"/>
    <dbReference type="STRING" id="59895.A0A103Y2A5"/>
    <dbReference type="Gramene" id="KVI01197">
        <property type="protein sequence ID" value="KVI01197"/>
        <property type="gene ID" value="Ccrd_020516"/>
    </dbReference>
    <dbReference type="OMA" id="EWMKYSS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000001">
        <property type="entry name" value="NAC domain-containing protein 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044799">
        <property type="entry name" value="SOG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31079">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31079:SF31">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="8">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="417" mass="47457" checksum="8AACADCAB8936764" modified="2016-04-13" version="1">MNISSCDLIDAKLEEHQLCGSKHCPGCGHKLEGKPDWVGLPAGVKFDPTDQELIEHLEAKVEAKNLKSHPLIDEFIPTIEGEDGICYTHPEKLPGVTRDGLSRHFFHRPSKAYTTGTRKRRKIQTECDLQGGETRWHKTGKTRPVMVNGKQKGCKKILVLYTNFGKNRKPEKTNWVMHQYHLGQHEEEREGELVVSKIFYQTQPRQCNWSERAMNNNILLNNIRSTEGVNIQMNEMNNGSSRRESRSGSGSCSSSKEVNVTPTTTITTATAATVTAHNNIGDELVGTVLSSYNPMDQMQHFKGVDQYSFMPYRKSFGEQQQQHMNLEDDQHQNPHHHQNYPHQHQVATTAFHVSRPSHAISAIISPSPLHHTSIILDDDSFHVARIMENFQECSITNPQEADWLKYSTFWPDPDHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2S8</accession>
    <name>A0A103Y2S8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003086">
        <property type="protein sequence ID" value="KVI01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2S8"/>
    <dbReference type="STRING" id="59895.A0A103Y2S8"/>
    <dbReference type="Gramene" id="KVI01464">
        <property type="protein sequence ID" value="KVI01464"/>
        <property type="gene ID" value="Ccrd_020265"/>
    </dbReference>
    <dbReference type="OMA" id="CTSIVRY"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF336">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119340" evidence="12">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="476" mass="53855" checksum="5C25BF7967A26EAC" modified="2016-04-13" version="1">MDWFYGSLLSLFVIFVSLTLGFLCHKKNPTENLEPPGRTGWPFLGETLEFLSTGWNGHPEKFVFDRMARYSSNVFKTSLLGSEAAVFCGPAGNKFLFSNEYKLVRMWVPESIKKLFPSKSSAAEEAMKMRKSFPVFLKPEALQKYVGVMDDITGKHFSTSWENHQVVAVYPLIKRFAFVIASRLFISVENPDHIARFAAPFDRLVSGIFSIPIDFPGTQFNKAIKASKHIRKELIDIIVQRKSDLGEGKASPKQDVLSHMLVTNGDGEDAMTDSDIANKLIALLLGGHDTIASTCTSIVRYLAELPHIYEGVYKEQMEVAKSKGPGEVLNWEDLQKMKYSWSVASEVLRLSPPFQGTFREALTDFTFNGFFIPKGWKIYWSTNGVHRNSVFFPDPLKFDPTRFEGGGPAPYTYVPFGGGARMCPGKEFARLEILVFMHHIVKRFRWQKIIPDEKIIVDPMPVPAEGLPVRLYPHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2U4</accession>
    <name>A0A103Y2U4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003079">
        <property type="protein sequence ID" value="KVI01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y2U4"/>
    <dbReference type="Gramene" id="KVI01476">
        <property type="protein sequence ID" value="KVI01476"/>
        <property type="gene ID" value="Ccrd_020252"/>
    </dbReference>
    <dbReference type="OMA" id="XDFELFL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="9">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="22783" checksum="DDA78B5336CD1595" modified="2016-04-13" version="1" fragment="single">MDHGKERKESMKQNKKTAEREFNMDEYKSLPISKESGIDAMSTIPGFNQIQFEGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTNQEXDFELFLERYQLVEPQITERDAVYESLTYSSELYVSARLIWKNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQILRSPGIYYKSEFNDNGIKKSRSHPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4R0</accession>
    <name>A0A103Y4R0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4R0"/>
    <dbReference type="STRING" id="59895.A0A103Y4R0"/>
    <dbReference type="Gramene" id="KVI02487">
        <property type="protein sequence ID" value="KVI02487"/>
        <property type="gene ID" value="Ccrd_019261"/>
    </dbReference>
    <dbReference type="OMA" id="NTSHEIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052453">
        <property type="entry name" value="CONSTANS-like_ZF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31874:SF25">
        <property type="entry name" value="CCT MOTIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31874">
        <property type="entry name" value="CCT MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCT" evidence="5">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="34420" checksum="7115C18C19341912" modified="2016-04-13" version="1">MIAQESTLTLKPSSRRSRTKLRKPRFLRLHLISAAPPPMPTTTNHHKQLINLFPLHPENLVDDQQDKLDEEHNMACIFSSCDDDGAATTLTGILRSDEEEEYTNNPSPSSVNYADEEVELVRTAMRRNKTERDDDDLKWVCYSEVVKEKKKVMIRGLSASSSSSTSSYHHRHHDHDHRNKLVLKLDYEKIMNSWVNKGPLYIHNNNPDIQTCERENGGNEGSWTVPEIPGTENNDTDGGDDTMQAIGSNEMIHRREASVQRYKEKRRNRLFAKTIRYEVRKLNAEKRPRIKGRFVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5J0</accession>
    <name>A0A103Y5J0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_018804</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002618">
        <property type="protein sequence ID" value="KVI02905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5J0"/>
    <dbReference type="STRING" id="59895.A0A103Y5J0"/>
    <dbReference type="Gramene" id="KVI02905">
        <property type="protein sequence ID" value="KVI02905"/>
        <property type="gene ID" value="Ccrd_018804"/>
    </dbReference>
    <dbReference type="OMA" id="FRCYVEK"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000003">
        <property type="entry name" value="Cytosolic ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000003">
        <property type="entry name" value="L-ascorbate peroxidase, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF38">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 5, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI02905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="31641" checksum="C2CF161B6173CAFA" modified="2016-04-13" version="1">MAAAAPVVDEQYLKEIEKARRDLRALISSKNCAPIMLRLAWHDAGTYDAKTKTGGPNGSIRNEEEYKHGANSGLKIAIDLCEEVKAKHPRVTYADLYQLAGVVAVEVTGGPTIDFAPGRKDSNVSPDEGRLPDAKQGPSHLRDVFYRMGLSDKDIVALSGGHTLGKAHPERSGFDAKPWTRDPLKFDNSYFVEVLKGDSDEMLLKLPTDTALLDDPSFRFYVELYAEDEEAFFKDYVESHKKLSELGFTPPSSLKSKNAAALLAQSAVGVAVAASVVILSYFYEINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6A4</accession>
    <name>A0A103Y6A4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002376">
        <property type="protein sequence ID" value="KVI03304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6A4"/>
    <dbReference type="STRING" id="59895.A0A103Y6A4"/>
    <dbReference type="Gramene" id="KVI03304">
        <property type="protein sequence ID" value="KVI03304"/>
        <property type="gene ID" value="Ccrd_018397"/>
    </dbReference>
    <dbReference type="OMA" id="HEWVEMV"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="155" mass="16823" checksum="D234DAEB0FFA499B" modified="2016-04-13" version="1">MAMASRFWASKAASYLKISTFNRAFASVVKDLRYADSHEWAKIDGNSATIGITDHAQDHLGDVVYVELPEVGVAVTQGSSFGAVESVKATSDINSPVSGKVVEVNQELSSSPGLVNGSPYEEGWIIKVELSNTNEVKSLMDSDQYSKFCEEEDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6B6</accession>
    <name>A0A103Y6B6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_018377</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002369">
        <property type="protein sequence ID" value="KVI03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6B6"/>
    <dbReference type="STRING" id="59895.A0A103Y6B6"/>
    <dbReference type="Gramene" id="KVI03321">
        <property type="protein sequence ID" value="KVI03321"/>
        <property type="gene ID" value="Ccrd_018377"/>
    </dbReference>
    <dbReference type="OMA" id="LEHEWIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000067">
        <property type="entry name" value="calcium-dependent protein kinase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000050">
        <property type="entry name" value="Calcium-dependent protein kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="58"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVI03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="520" mass="58548" checksum="6A0A203564FC638C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6E2</accession>
    <name>A0A103Y6E2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002358">
        <property type="protein sequence ID" value="KVI03365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6E2"/>
    <dbReference type="STRING" id="59895.A0A103Y6E2"/>
    <dbReference type="Gramene" id="KVI03365">
        <property type="protein sequence ID" value="KVI03365"/>
        <property type="gene ID" value="Ccrd_018335"/>
    </dbReference>
    <dbReference type="OMA" id="RSESTWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043561">
        <property type="entry name" value="LHW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH155-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR LHW-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23176">
        <property type="entry name" value="bHLH_LHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor MYC/MYB N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="487"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="686" mass="76599" checksum="6B220196D80A419A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7C6</accession>
    <name>A0A103Y7C6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor MYC/MYB N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7C6"/>
    <dbReference type="STRING" id="59895.A0A103Y7C6"/>
    <dbReference type="Gramene" id="KVI03861">
        <property type="protein sequence ID" value="KVI03861"/>
        <property type="gene ID" value="Ccrd_017819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043561">
        <property type="entry name" value="LHW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH155-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR EMB1444-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor MYC/MYB N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="42894" checksum="B90DB3DFAC97C9AB" modified="2016-04-13" version="1">MGVSALHQALETLCVNADWNYAVYWKLDPQARMMLTCEDAYYDKNDPSGSKRFDNLPDEHYAQDLLDLAVAKMSYQRYSLGEGIVGQVAVTDKHLWLSGDQIVNDPCLSFEDYDGWKTQFAAGIRISEDLKLVNHIREIFLELQSSLTGCIPSSTSSYNDADTSVNFRINRISDLDRNRELGMPVSLNPHMLISSDENLESQSDTDAMNALKTSFKFPAGCELYEALGPAFCEQTENPVWRTADEMLGMGGSNLLTPNSGPEHLLEAVVANVCQTDSEFSNPVKWVEPDPPLNDMQTSGSGCYSFESPFLVKDDMLTSTETYGSSLGFSSASHSRCSEPRSQEPANVGKKRARPDDVRGRRSFSRDSRRHQELGPHHFERRNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7W7</accession>
    <name>A0A103Y7W7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002305">
        <property type="protein sequence ID" value="KVI04144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7W7"/>
    <dbReference type="STRING" id="59895.A0A103Y7W7"/>
    <dbReference type="Gramene" id="KVI04144">
        <property type="protein sequence ID" value="KVI04144"/>
        <property type="gene ID" value="Ccrd_017534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010089">
        <property type="term" value="P:xylem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039280">
        <property type="entry name" value="VUP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33974:SF2">
        <property type="entry name" value="VASCULAR-RELATED UNKNOWN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33974">
        <property type="entry name" value="VASCULAR-RELATED UNKNOWN PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="25574" checksum="C3412029276D031F" modified="2016-04-13" version="1" fragment="single">YKWLPFFLILLYYLSLLYNQPSFIFFSLSLSLSFLMDSDHSSYSSMNKSMAESETATAEESGWTSYFEDFMAAQQKDHHQNHSFTDHYHHHQNHSFTDHYHHHHHHHHHHQQQHLDDQPVVSDAVSHVEWNYIDQSMSGAAPKFPKKLNLFKKTSRRTREILYDDSLEDTASSPVNSPKVGSQQMGFNQIKVDDIIQNSLVTFYQLLGLLFSAKNNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8H6</accession>
    <name>A0A103Y8H6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002044">
        <property type="protein sequence ID" value="KVI04467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8H6"/>
    <dbReference type="STRING" id="59895.A0A103Y8H6"/>
    <dbReference type="Gramene" id="KVI04467">
        <property type="protein sequence ID" value="KVI04467"/>
        <property type="gene ID" value="Ccrd_017212"/>
    </dbReference>
    <dbReference type="OMA" id="NEFDIWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043376">
        <property type="entry name" value="NPG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102">
        <property type="entry name" value="PROTEIN NPG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102:SF5">
        <property type="entry name" value="PROTEIN NPG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="723" mass="80275" checksum="FE3608FD7FD968A3" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA69</accession>
    <name>A0A103YA69_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor, TCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001878">
        <property type="protein sequence ID" value="KVI05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA69"/>
    <dbReference type="STRING" id="59895.A0A103YA69"/>
    <dbReference type="Gramene" id="KVI05334">
        <property type="protein sequence ID" value="KVI05334"/>
        <property type="gene ID" value="Ccrd_016337"/>
    </dbReference>
    <dbReference type="OMA" id="MRLSVHT"/>
    <dbReference type="OrthoDB" id="1896834at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000032">
        <property type="term" value="P:regulation of secondary shoot formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017887">
        <property type="entry name" value="TF_TCP_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005333">
        <property type="entry name" value="Transcription_factor_TCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072:SF87">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03634">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51369">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TCP" evidence="6">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="407" mass="45787" checksum="31D41881EC84D30E" modified="2016-04-13" version="1">MDYMFPSRNTETLLVSSDKLTNHENVNSSHEEEPPLFLQFPSPFLDMDTTTILPNLHQQHHLSTHGCRTTTVSSLNKPMKLSNATSNPLALASKGKCVRKRRSVGKKDRHSKIHTAQGLRDRRMRLSVHTARKFFDLNDLLGFDKASKTIEWLFSKSKKAIEEVTESFQSDDAAQAAVCGETIESESPLSACENESVNDIITATDKGENLELQSDQIRDTNSRKWMEIYPSVRESKGKAREESRERMVIKHLEKPKQLFEADPEVHLNQPQLGFSENPDNHNIEESPCFPLEYSNTYHFLKQLHLDNTVSKTNTYLGNITSISSTNCSMFDHYNKNIAEPPAGWLNSRNTFLGFLGGWDSGSSRMESGNPLTVPNIAPLKGSTNGENPNSSIISSDFVNFHSQNQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBZ5</accession>
    <name>A0A103YBZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calmodulin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant ACBP60 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001838">
        <property type="protein sequence ID" value="KVI06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBZ5"/>
    <dbReference type="STRING" id="59895.A0A103YBZ5"/>
    <dbReference type="Gramene" id="KVI06314">
        <property type="protein sequence ID" value="KVI06314"/>
        <property type="gene ID" value="Ccrd_015340"/>
    </dbReference>
    <dbReference type="OMA" id="DIPHENC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046829">
        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF79">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="9">
        <location>
            <begin position="121"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="10">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein C-terminal" evidence="11">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="582" mass="65962" checksum="89DE20429F576695" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC01</accession>
    <name>A0A103YC01_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amine oxidase</fullName>
            <ecNumber evidence="17">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_015364</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-methylputrescine + O2 + H2O = 4-methylaminobutanal + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:71015"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58039"/>
            <dbReference type="ChEBI" id="CHEBI:190141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71016"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16154"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="17">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="17">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="16">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="16 17">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01001840">
        <property type="protein sequence ID" value="KVI06294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC01"/>
    <dbReference type="STRING" id="59895.A0A103YC01"/>
    <dbReference type="Gramene" id="KVI06294">
        <property type="protein sequence ID" value="KVI06294"/>
        <property type="gene ID" value="Ccrd_015364"/>
    </dbReference>
    <dbReference type="OMA" id="WANRKES"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052597">
        <property type="term" value="F:diamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000004">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF18">
        <property type="entry name" value="AMINE OXIDASE [COPPER-CONTAINING] ZETA, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 17" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="19">
        <location>
            <begin position="77"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="20">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="18">
        <location>
            <begin position="331"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="15">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="16">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI06294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="776" mass="86254" checksum="156AF8F06B8B2E05" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCB2</accession>
    <name>A0A103YCB2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001830">
        <property type="protein sequence ID" value="KVI06441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCB2"/>
    <dbReference type="STRING" id="59895.A0A103YCB2"/>
    <dbReference type="Gramene" id="KVI06441">
        <property type="protein sequence ID" value="KVI06441"/>
        <property type="gene ID" value="Ccrd_015237"/>
    </dbReference>
    <dbReference type="OMA" id="SSAGHWE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000242">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF469">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="461"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="541" mass="61466" checksum="A0E0F2057E36C764" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCG3</accession>
    <name>A0A103YCG3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase/kelch, beta-propeller</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001812">
        <property type="protein sequence ID" value="KVI06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCG3"/>
    <dbReference type="STRING" id="59895.A0A103YCG3"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF79">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119603" description="Galactose oxidase/kelch, beta-propeller" evidence="2">
        <location>
            <begin position="29"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="435"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59487" checksum="6867F91780D41827" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCJ5</accession>
    <name>A0A103YCJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001786">
        <property type="protein sequence ID" value="KVI06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YCJ5"/>
    <dbReference type="Gramene" id="KVI06607">
        <property type="protein sequence ID" value="KVI06607"/>
        <property type="gene ID" value="Ccrd_015043"/>
    </dbReference>
    <dbReference type="OMA" id="FPWISRR"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20654">
        <property type="entry name" value="CYP82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000026">
        <property type="entry name" value="Cytochrome P450 82C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF61">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="530" mass="59998" checksum="5DB457B2B7187DC9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE73</accession>
    <name>A0A103YE73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE73"/>
    <dbReference type="STRING" id="59895.A0A103YE73"/>
    <dbReference type="Gramene" id="KVI07465">
        <property type="protein sequence ID" value="KVI07465"/>
        <property type="gene ID" value="Ccrd_014168"/>
    </dbReference>
    <dbReference type="OMA" id="MMKQQEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001664">
        <property type="entry name" value="suppressor of mec-8 and unc-52 protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="449" mass="50679" checksum="22F3D3B25A4B5A8E" modified="2016-04-13" version="1">MSALEIEARDVIKIVLQFCKENSLHQTFQTLQNECQVSLNTVDSLETFVADINSGRWDAILPQVAQLKLPRKKLEDLYEQIVLEMIELRELDTARAILRQTQAMSVMKQEQPERYLRLEHLLVRTYFDPHEAYQDSTKEKRRSQISQAIAGEVSVVPPSRLMALIGQALKWQQHQGTAAMKQDVDDKYPTTLGHTIKFGKKSHPESARFSPDGQFLVSCSVDGFIEVWDHISGKLKKDLQYQAEESFMMHDDAVLCIDFSRDSEMLASGSQDGKIKVWRIRNGQCLRRLENAHSQGVTSVAFSRDGSQLLSTSFDGTARIHGIKNGKLLKEFRGHSSYVNDAIFTSDGLRVITASSDCTVKVWDLKSTDCLQTFKPPPPLRGGDASVNSVHLSPKNPDHVIVCNKTSSIYLMTLQGQVHEKDVIGICHHPHRNLVATYGEDCTMKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHD5</accession>
    <name>A0A103YHD5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHD5"/>
    <dbReference type="STRING" id="59895.A0A103YHD5"/>
    <dbReference type="Gramene" id="KVI09112">
        <property type="protein sequence ID" value="KVI09112"/>
        <property type="gene ID" value="Ccrd_012506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="159" mass="17160" checksum="7ADEF79160FF13F1" modified="2016-04-13" version="1">MAKQALSDALSLDKPSIFLDNFPAPQPTSSYNTSTQTTTYASSTGNIANLLKGFMKNAPISSKSSSDSSTCKTTGIDSSEGFESLLGFDQSFGSPNGSDLSLSNMSPKESKPELIGAQLPFTMFENWLLDEAGGDDVINQRKTDLTHFAFDQNPDHFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHR7</accession>
    <name>A0A103YHR7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001066">
        <property type="protein sequence ID" value="KVI09293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHR7"/>
    <dbReference type="STRING" id="59895.A0A103YHR7"/>
    <dbReference type="Gramene" id="KVI09293">
        <property type="protein sequence ID" value="KVI09293"/>
        <property type="gene ID" value="Ccrd_012323"/>
    </dbReference>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="914"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131133" checksum="A2DFAEB7F83BD531" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI66</accession>
    <name>A0A103YI66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001058">
        <property type="protein sequence ID" value="KVI09502.1"/>
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    <dbReference type="OMA" id="YEMCLGQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:auxin influx transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:anthocyanin accumulation in tissues in response to UV light"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:photomorphogenesis"/>
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        <property type="term" value="P:positive regulation of brassinosteroid mediated signaling pathway"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:response to auxin"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0048443">
        <property type="term" value="P:stamen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000029">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
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    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="251"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="275"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="759"/>
            <end position="787"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="807"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="907"/>
            <end position="924"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="109"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="431"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="763"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1086"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1350" mass="147808" checksum="A85F1B3D03A1C9D9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ93</accession>
    <name>A0A103YJ93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ93"/>
    <dbReference type="Gramene" id="KVI10088">
        <property type="protein sequence ID" value="KVI10088"/>
        <property type="gene ID" value="Ccrd_011527"/>
    </dbReference>
    <dbReference type="OrthoDB" id="689613at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34961">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34961:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119777" evidence="2">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="159" mass="17417" checksum="E82F11F756BAC628" modified="2016-04-13" version="1">MVSMASLLLVAFFYLVPCMHSSNARLLSAISKPFPANPHHGSISLQVAEKNGGDEMVERTGSDAQPPATTTFLKAEFEEFLTHDDSKKINGGGVVVVKEGSDIVESSISHHVALLEGTHIKGSERPITSEYHEKEEVKNDDVTVTDYQPPHRKTPIHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJF7</accession>
    <name>A0A103YJF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJF7"/>
    <dbReference type="Gramene" id="KVI10132">
        <property type="protein sequence ID" value="KVI10132"/>
        <property type="gene ID" value="Ccrd_011465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="245" mass="27819" checksum="3DCFC2489D121136" modified="2016-04-13" version="1" fragment="single">MCGFNKKLDAKKPCCSPSTPFIYVKSHLPSLLARFSGEHTSLDFTFLAIGCDEFTTSIYRAIDNIRKEAEAETRLPMDPMLLSPATGISDGNNFLHEWGSGDEEPFQKHMDRDKVACLIPTPRPIKFESDSVVTVQAGPYFAGTSTSESCDQGIKEHRRFFKEEAEEITNAESQNSYEPENASDITLDLLLDFPNDGEYLQNKRFNWDESFFLLLLGGGDRWLRLALGFHLYLLGFFYCHIFVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJZ0</accession>
    <name>A0A103YJZ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJZ0"/>
    <dbReference type="STRING" id="59895.A0A103YJZ0"/>
    <dbReference type="Gramene" id="KVI10402">
        <property type="protein sequence ID" value="KVI10402"/>
        <property type="gene ID" value="Ccrd_011176"/>
    </dbReference>
    <dbReference type="OMA" id="FAIDLMI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="491" mass="54996" checksum="02F843B7B565F181" modified="2016-04-13" version="1">MDQNLRFSVHTLETADNSSSSVGFSPSGSPVSLQDSHSFQPGLYHSPDQTYTSHINPAAGNVDELELRLRELEAAMLGSDQDFEEFDVSSSWDGYGPEDINQENDEFRIMEELTSRGDLKQALLACAKAIAENKLTTAEQEQLISMARPLVSVSGEPAQRLGAYMLEGLAARIYESGSIIYKTLKCKEPTSGELLSYMLLLYEACPYFKFGYLSANGAIAEATKNEDRIHIVDFQIAQGGQWVTLIQALAARPGGPPKLRITGIDDPRNNYARGGGLNIVGRRLEMLAESCKVPFEFHGVPVSGSDIQIEHLGVRPGEALAVNCAFVLHHMPDESVDPRNHRDRLLRLIKSLSPKVVTLVEQEANVNTALFFHRFQEAFSYYSAMFESIDATLERDHRERINIEKHCLAGEIVNIIACEGTEREERHELLGKWKTRFRMAGFSPYPLSSYVNATIKTLLENYCDRYRLQERDGALFLGWMNRDLVSSCAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKF7</accession>
    <name>A0A103YKF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C48, SUMO/Sentrin/Ubl1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000997">
        <property type="protein sequence ID" value="KVI10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKF7"/>
    <dbReference type="Gramene" id="KVI10805">
        <property type="protein sequence ID" value="KVI10805"/>
        <property type="gene ID" value="Ccrd_010789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="16005" checksum="5796D08DE1258B09" modified="2016-04-13" version="1">MYDFITDILQRLMIRHLNAVGHPAGRELDEIGQERLRMDWQTQNNFDDCGVFAMRHMKTYIGDVRTWKTGLAQEGKTQEIQIASLRMKYVAKLLVSNYNKKKEYVVNEVEKFQSMDKAIRKRLRKHADNTKTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN56</accession>
    <name>A0A103YN56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN56"/>
    <dbReference type="STRING" id="59895.A0A103YN56"/>
    <dbReference type="Gramene" id="KVI12199">
        <property type="protein sequence ID" value="KVI12199"/>
        <property type="gene ID" value="Ccrd_009339"/>
    </dbReference>
    <dbReference type="OMA" id="VAAAHTM"/>
    <dbReference type="OrthoDB" id="1654714at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35505">
        <property type="entry name" value="OS01G0600300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35505:SF5">
        <property type="entry name" value="SUBSTRATE CARRIER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="518" mass="57724" checksum="A38AF4B1799F4E89" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNR0</accession>
    <name>A0A103YNR0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF538 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNR0"/>
    <dbReference type="STRING" id="59895.A0A103YNR0"/>
    <dbReference type="Gramene" id="KVI12462">
        <property type="protein sequence ID" value="KVI12462"/>
        <property type="gene ID" value="Ccrd_009080"/>
    </dbReference>
    <dbReference type="OMA" id="DECHDCG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF156">
        <property type="entry name" value="F22D16.19 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119884" description="DUF538 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18033" checksum="CE8030B98CF756B3" modified="2016-04-13" version="1">MSSPATILCFFILLLISAAITVAEKPTVYEVLKQYDFPAGLLPTGVTDYTLNNSTGEFEVMLGETCSFSVDGYDLKYKSTISGVISKDKLRKLKGVSVKLLFIWVDIVEVSRDEDELDFSVGILSAGFDIEGFEESPECGCGFDCNGLEIEGEKKSEVDDLFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118FDG9</accession>
    <name>A0A118FDG9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009648">
        <property type="protein sequence ID" value="KVF26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118FDG9"/>
    <dbReference type="Gramene" id="KVF26817">
        <property type="protein sequence ID" value="KVF26817"/>
        <property type="gene ID" value="Ccrd_026836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF26817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="33" mass="3900" checksum="8539368911D5E48E" modified="2016-04-13" version="1">MQNGCMSQGLWLTALFRYPLLCPAMKRNEEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118J7F3</accession>
    <name>A0A118J7F3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, LSD1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_025674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006692">
        <property type="protein sequence ID" value="KVH57117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118J7F3"/>
    <dbReference type="STRING" id="59895.A0A118J7F3"/>
    <dbReference type="Gramene" id="KVH57117">
        <property type="protein sequence ID" value="KVH57117"/>
        <property type="gene ID" value="Ccrd_025674"/>
    </dbReference>
    <dbReference type="OMA" id="PGMDIAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040319">
        <property type="entry name" value="LSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747:SF3">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH57117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="235" mass="25390" checksum="7AFB2BB227BD5700" modified="2016-04-13" version="1">METVGDGDGERRPPTETMIDDGEQSMEERRPLWEKIETRSTTAVKIKPYFGLVDFQRNMQSQIVCSGCRSILLYPRGASNVCCALCNAVTSVPPPGMEMDQLICGGCRTLLMYTRGATSVRCSCCHTVNLAPVSNQLAQVNCGNCRTMLMYPFGAPSVKCAVCHYITNVNMSSGRVPVSMRPNGNATSGSMPSVSTETPHSHNQTVVVENPMSVDESGKLVSNVVVGVTTEKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSC6</accession>
    <name>A0A118JSC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005370">
        <property type="protein sequence ID" value="KVH88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSC6"/>
    <dbReference type="STRING" id="59895.A0A118JSC6"/>
    <dbReference type="Gramene" id="KVH88572">
        <property type="protein sequence ID" value="KVH88572"/>
        <property type="gene ID" value="Ccrd_026472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS07G0563300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245:SF19">
        <property type="entry name" value="TF-B3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="39917" checksum="ACCD97A972F2D858" modified="2016-04-13" version="1" fragment="single">LCDSCLNPQRSISPPSWSRPAASFRKRSSEKTSVISTSSIPVRGPAAVQTPCLLNSSNTEPQPQPQVDISVRPTQPSWLGERKNSSVKRSSQIRASHVIKDKTAVGTEHSPSRHLLGSKSFTAQSRHGNDHLLDRYMPKQLTASDAGRVGRLVLPKRCAEAYFPPVNEPFGEPLSIQDTEGKNWDLNLRFWPNNNSRMYVLEGFSLVVKSVELVEGDVVTFSRLEPEGKLIMGYRKAKSTALSLKQVGLFFRQATGAIVTVSPRNDVSKGNTSSAAVSQMKPDDPTSNIQSEVVRAKAAGRSKRKSSKMGWGSDINEPEKEMVELDLTSKEAQELVRPPLGGRVPKSVDVPVIGRPTIIENLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSM9</accession>
    <name>A0A118JSM9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSM9"/>
    <dbReference type="Gramene" id="KVH89454">
        <property type="protein sequence ID" value="KVH89454"/>
        <property type="gene ID" value="Ccrd_008563"/>
    </dbReference>
    <dbReference type="OMA" id="IQQAHAF"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000690">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000470">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g66520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF436">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="536" mass="59697" checksum="6B2AE72BEC35A903" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT64</accession>
    <name>A0A118JT64_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005125">
        <property type="protein sequence ID" value="KVH89922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT64"/>
    <dbReference type="STRING" id="59895.A0A118JT64"/>
    <dbReference type="Gramene" id="KVH89922">
        <property type="protein sequence ID" value="KVH89922"/>
        <property type="gene ID" value="Ccrd_008082"/>
    </dbReference>
    <dbReference type="OMA" id="VTSQVWQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF111">
        <property type="entry name" value="NEPROSIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="1">
        <location>
            <begin position="81"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="35701" checksum="5896F559340BD3D9" modified="2016-04-13" version="1" fragment="single">GDIIDCVEIYKQPSLNHPALKNHTIQLAPTFFSKTRKVFDDAKKEDIAMTITSQRWQKSGSCPKGTVPIRRTQKRNPNKDDFHAYGRKTASNMKNEVGDLKYTTNSTNSIANHSVALIETVGYSYSGAKVDIKVWTPYVEKEDEYSTSHVNPSVYDDHQTRFVQVNHEIALGGAIYPISNPNGLPYQITDPTTKNWWVNYGESINIGYWPGELFMLLKYQGIMVKWGGEVYSSKVKTHPGHTATGMGSGNTPPSIFENCGTMKRMRVEQNSQPLMIPEWSTTVVDEYRCYGALYEVDYIPDPIFYYGGPGRSPWCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTA1</accession>
    <name>A0A118JTA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005199">
        <property type="protein sequence ID" value="KVH89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTA1"/>
    <dbReference type="STRING" id="59895.A0A118JTA1"/>
    <dbReference type="Gramene" id="KVH89557">
        <property type="protein sequence ID" value="KVH89557"/>
        <property type="gene ID" value="Ccrd_008452"/>
    </dbReference>
    <dbReference type="OMA" id="HEQANIK"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="36180" checksum="A484487648A4135F" modified="2016-04-13" version="1">MDQIKHKFIQAGELRLHVAEIGEESSPVVLFLHGFPEIWYTWRYQMVAVANAGFRAIAPDYRGFGLSDVPAEPEKTTFAALIEDITTILCSLAISKVFVIGKDFGSMVGYIFAVFFPKKLAGIITLGIPYMPPQVLQQLQTLPEGFYMRRWQEPGRAEADFGRYDAKTVVRKIYILFSRSEVPIASENQEILDLVEPWAPLPCWFTEKDLEIYGALYAKSGFQTALQVPYRSLQERVEPPNQDPNNLRIEAPALFITGTEDFFFNIPGIQEYLKNGVKNYVPNLEIIYLPKGSHFVPEQFPHKVNQLLINFLNCNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU00</accession>
    <name>A0A118JU00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Late embryogenesis abundant protein, LEA-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005096">
        <property type="protein sequence ID" value="KVH90744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU00"/>
    <dbReference type="STRING" id="59895.A0A118JU00"/>
    <dbReference type="Gramene" id="KVH90744">
        <property type="protein sequence ID" value="KVH90744"/>
        <property type="gene ID" value="Ccrd_007256"/>
    </dbReference>
    <dbReference type="OMA" id="DNHMSAT"/>
    <dbReference type="OrthoDB" id="669838at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF39">
        <property type="entry name" value="HARPIN-INDUCED PROTEIN 1 CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="6">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="202" mass="23048" checksum="C1876B219023629E" modified="2016-04-13" version="1">MANAKPLTQNQPAPSRFNLVRLIAIVLLTLIVLVGLTILIIWLTIKPKKLVYSIDDAAVHNYVLSNSNHLNATYYFILRAYNPNKKVSIYYDKVDVVVLYDDETLSTGTIDPFYQPKRNATSFKLNLSSRDVSLPQQIARDMKVERSSGQIEMTVKLKARIRFKVGVWKSRHYGMRVTCAPIMVHYSYSSKGFQKISCDVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ5</accession>
    <name>A0A118JZZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003364">
        <property type="protein sequence ID" value="KVI00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ5"/>
    <dbReference type="STRING" id="59895.A0A118JZZ5"/>
    <dbReference type="Gramene" id="KVI00632">
        <property type="protein sequence ID" value="KVI00632"/>
        <property type="gene ID" value="Ccrd_021101"/>
    </dbReference>
    <dbReference type="OMA" id="IYKAPEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000079">
        <property type="entry name" value="Protein SRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="359" mass="40708" checksum="54F2F9952A657022" modified="2016-04-13" version="1">MATLNLGSSIPVPSIKELVAQPLDTVPLRYIRDLDADYPTAAAFPGDSSVQLPLLDMAKLVDPQYQEIELQKLHDACKNWGIFQLIGHGVPDESLKAMHKKTQEFFDLSPEDKNQYAQKPGSLEGYGQAFVISEDQKLEWCDMIFLKAIPTHTRKLEFWPEEQPRNFREALHVYSHDMRKTAVSIIGFIAMALGLDFKDFREVFEGGNYDVRMNCYPPCPEPERVIGISSHADLSGITLLTDCGDIPGLQVLKDGRWVFVEPITDGMVVNIGIIMEIVSNGVYKAPYHRAAVNRHKDRFSIVTFCYPSKKFDIKPAKELINPDSLALYKSFTNDEYFRSFYERTELSDDGVPFIDTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0P5</accession>
    <name>A0A118K0P5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003005">
        <property type="protein sequence ID" value="KVI01588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0P5"/>
    <dbReference type="STRING" id="59895.A0A118K0P5"/>
    <dbReference type="Gramene" id="KVI01588">
        <property type="protein sequence ID" value="KVI01588"/>
        <property type="gene ID" value="Ccrd_020136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="11172" checksum="054431C3724BAD4A" modified="2016-04-13" version="1" fragment="single">NSVTPCNFGKPNNTSGHCGAIIWYEERSRKDRKTSNPKFLSNLIVGDLSKNTFERDVIVKHRTTRLQRITDLHPSFMSMTYSLIHPYDEDGFRRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K118</accession>
    <name>A0A118K118_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002661">
        <property type="protein sequence ID" value="KVI02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K118"/>
    <dbReference type="STRING" id="59895.A0A118K118"/>
    <dbReference type="Gramene" id="KVI02160">
        <property type="protein sequence ID" value="KVI02160"/>
        <property type="gene ID" value="Ccrd_019556"/>
    </dbReference>
    <dbReference type="OMA" id="VHQESAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37911:SF1">
        <property type="entry name" value="OS04G0497900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37911">
        <property type="entry name" value="OSJNBA0067K08.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="503" mass="59073" checksum="16501ABA5B50B51C" modified="2016-04-13" version="1">MLPHNPSFFKTLNPYFSTFTKPYPLPTKFSNPLYKTLIPFHSSPQISSLKCLFQPKPNNASCTPDVRSYAGRSKKQPGGTSTGRIEGNAELRREAKRNARRKSKKLAENLFYRLKNPHGNYPNNFSEEELQMIGLGYDRMVQFMEKDDPNLKHPYDWYKYGEFGPYSWRGVVLGEPIRGRFSDENVTLIGEVRDQEEWEKIEQFEMSQDFGQRMESMDRNVGFRYFWVFVRHPKWRVSELPWEQWTLVSEVVVESGKQRLDKWNLMGRLGNQTRSLITKCAAWMRPDIIYVKRPVYQCRFEPQDEFFKAMVPLLDPASEQDFMCELESDDGGVEMCTYFGGLCKILRVNPKAFVDDVVKAFEKASDEKKSKCLEFVLGNHPIELLHPYTKEWKAKLEDMERSVQMTTKLYEKQSRVMEEKERKVKEENENDDRELRGRAKISPEEWEKLGYGPRMKKIKKSRIPPGQFLRAAVRPFRYKNLVKEIVLTRHAIVEGEIGGDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K181</accession>
    <name>A0A118K181_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K181"/>
    <dbReference type="STRING" id="59895.A0A118K181"/>
    <dbReference type="Gramene" id="KVI02488">
        <property type="protein sequence ID" value="KVI02488"/>
        <property type="gene ID" value="Ccrd_019268"/>
    </dbReference>
    <dbReference type="OMA" id="QNARNHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000041">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF121">
        <property type="entry name" value="SERINE_THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="510" mass="58886" checksum="19951AE0672BC0C8" modified="2016-04-13" version="1">MINKIFNRLPRKPHKSSENRDGGNSNSSSNTSTSSRNNNDVANTRSSSSNAPSVHPSNALIHTNSKLLQSQNSKSNGRSLVSDTYELLPSFKDVPTSEKQNLFIRKLNLCCVVFDFTDPTKNLKEKEIKRQTLAELVDYVSAVNGKFSETIMQEIVKMVSVNIFRRLTPQPRDNKVLETFDGEEEEPSMDPSWPHLQLIYEFVLRFVASPETDPKLAKRYIDHGFVLKWLDLFDSEDPREREYLKFVLHRMYGKFMVHRPFIRKSINNIFFRFVFETEKHNGIAELLEILGSIINGFALPLKEEHKLFLVRALIPLHKPKCIPMYHQQISYCITQFVEKDCKLADTVIRGLLKYWPITNSSKEVMFLSELEEVLEATQPPEFQRCMVPLFRQIARCLSSSHFQNLIRQNRKVILPIIFPALERNTKTHWNQAVQSLTLNVRKIFSDADPQLFEECSRKFKEDESRKEETKSKREITWKRLEEVAALGSGCSNEPVLSSQKSIANHVTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K225</accession>
    <name>A0A118K225_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_017954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K225"/>
    <dbReference type="STRING" id="59895.A0A118K225"/>
    <dbReference type="Gramene" id="KVI03705">
        <property type="protein sequence ID" value="KVI03705"/>
        <property type="gene ID" value="Ccrd_017954"/>
    </dbReference>
    <dbReference type="OMA" id="ISKWGHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001450">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001747">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="222"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="488" mass="55056" checksum="36AA0CB395D9919A" modified="2016-04-13" version="1">MEMESTLKEYYGFSTFRPYQKEIIEKILGGRDSLVVMATGSGKSLCYQVPPLIAKKTAIVISPLISLMQDQVMALKQRGIKAEHLSTAQTNLSAQRNAENGEYDILYMTPEKACFVPNSFWSRLLTTGICLVAVDEAHCISEWGHDFRVEYKQLYKLRDVLLDVPFVGLTATATEKVRNDIVDSLRMKDPHVAIGSFDRKNLYYGVKSINRGSSFVDELVAQISKHVANAGSTIVYCTTIKDVQEITKSLCEVGIKAGMYHGQMSNKAREESHRSFIRDELQVMVATIAFGMGIDKPDIRHVIHYGCPKSLESYYQESGRCGRDGITSDCWLYFSRSDFGKAEFYCGEASSVNQKKAIMDSFMAAQRYCMKATCRRKLLLEYFGETFASNKCGNCDNCTDSKEESDISREAFLLMGCIQSCGGYWGLNLPIDVLRGSRHRNAQSVEVLMIVLVDRRPRRLLKTSLTISHTMDLEKIFQQIGGRCWVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2A3</accession>
    <name>A0A118K2A3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002314">
        <property type="protein sequence ID" value="KVI04048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2A3"/>
    <dbReference type="STRING" id="59895.A0A118K2A3"/>
    <dbReference type="Gramene" id="KVI04048">
        <property type="protein sequence ID" value="KVI04048"/>
        <property type="gene ID" value="Ccrd_017654"/>
    </dbReference>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="653" mass="72549" checksum="E2D28014A60F442D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2C2</accession>
    <name>A0A118K2C2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002305">
        <property type="protein sequence ID" value="KVI04143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2C2"/>
    <dbReference type="Gramene" id="KVI04143">
        <property type="protein sequence ID" value="KVI04143"/>
        <property type="gene ID" value="Ccrd_017539"/>
    </dbReference>
    <dbReference type="OMA" id="TMLETHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000029">
        <property type="entry name" value="Coiled-coil domain-containing protein 90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF20">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="198" mass="22315" checksum="B0C7258797F4EC08" modified="2016-04-13" version="1">MSVGLRRFVQRGINSGFQVKSMKNNGFSNSLLVPNRCDYNFRRHLSQLVNPKGVRICLVDTLALVRRLEAQGVPSKQAEAITSAITEVLNDSLESVADTFTSNADMQKTVMLQEAHLSKFKSEVQSSQEHHFSSLQRETEKLRTDIDKMRSELRYEIDKEIHGLRAQVEAAKYDVIKYCIGTLISISAVGLAVIRILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2K4</accession>
    <name>A0A118K2K4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002018">
        <property type="protein sequence ID" value="KVI04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2K4"/>
    <dbReference type="STRING" id="59895.A0A118K2K4"/>
    <dbReference type="Gramene" id="KVI04515">
        <property type="protein sequence ID" value="KVI04515"/>
        <property type="gene ID" value="Ccrd_017168"/>
    </dbReference>
    <dbReference type="OMA" id="WATVANC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF27">
        <property type="entry name" value="TREHALOSE-PHOSPHATE PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="30814" checksum="565BE172AB7BCA6B" modified="2016-04-13" version="1">MHLKSNHSAPVLIDPMNKSRLGLYDALLPYSSGAVFSPGLFLTVTWKKPGVHCDVRSTSSLDAMQSSSPTHRKLKIDSGIDISSNDVAVAYGNWMLKYPSALTSFDHIINNAKGKRIALFLDYDGTLSPIVDNPDLAFMSDAMRTAVKNVAKDIPTTIISGRSRVKVHEFVGLRELYYAGSHGMDIMGPVRPPNDHMDDIIWCSGNEGEEGNLFQPASEFLPMINEVLEVRPVLKWDKGKAVEFLLESLAPKESSAFYSLRDPSEVMEFLKLLSDDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2N5</accession>
    <name>A0A118K2N5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001957">
        <property type="protein sequence ID" value="KVI04633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2N5"/>
    <dbReference type="Gramene" id="KVI04633">
        <property type="protein sequence ID" value="KVI04633"/>
        <property type="gene ID" value="Ccrd_017049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012859370" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="56" mass="6757" checksum="47EF92AEB9ECC196" modified="2016-04-13" version="1">MTFLVFSTSIVPLWAWMKQLYNEDLDNLKVLLDETIYYDKQWQVTWPNEKRESGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2T6</accession>
    <name>A0A118K2T6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_016816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001904">
        <property type="protein sequence ID" value="KVI04860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K2T6"/>
    <dbReference type="Gramene" id="KVI04860">
        <property type="protein sequence ID" value="KVI04860"/>
        <property type="gene ID" value="Ccrd_016816"/>
    </dbReference>
    <dbReference type="OMA" id="WAYLYEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08301">
        <property type="entry name" value="alcohol_DH_plants"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001292">
        <property type="entry name" value="Alcohol dehydrogenase class-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF40">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="206"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="42128" checksum="2B75B00449F22320" modified="2016-04-13" version="1">MSTNVGQVIRCKAAVAWEAGKPLVIEEVEVAPPQKMEVRIKILFTSLCHTDVYFWEAKGQNPVFPRILGHEAGGIVESVGEGVTDLQPGDHVLPVFTGECKECAHCKSEESNMCDLLRINTDRGVMIHDQKSRFSIQGKPIFHFVGTSTFSEYTVVHVGCLAKINPLAPLDKVCVLSCGISTGLGATLNVAKPKKGSSVAIFGLGAVGLAAAEGARIAGASRIIGVDLNANRFELAKKFGVTEFVNPKDXKKPVQEVIAEMTNGGVDRSVECTGHIDAMISAFECVHDGWGVAVLVGVPHKDAVFKTNPVNLLNERTLKGTFFGNYKPRSDLPSVVEKYMNKELEVEKFITHEVPFSEINKAFDLMXVKVFVASFAWMHRYLFKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K405</accession>
    <name>A0A118K405_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001667">
        <property type="protein sequence ID" value="KVI06750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K405"/>
    <dbReference type="STRING" id="59895.A0A118K405"/>
    <dbReference type="Gramene" id="KVI06750">
        <property type="protein sequence ID" value="KVI06750"/>
        <property type="gene ID" value="Ccrd_014895"/>
    </dbReference>
    <dbReference type="OMA" id="LFQGQAC"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000022">
        <property type="entry name" value="Aspartyl protease AED3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF839">
        <property type="entry name" value="ASPARTYL PROTEASE AED3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159933" evidence="9">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="99"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="441" mass="46783" checksum="6A4303793AB8249F" modified="2016-04-13" version="1">MDSTILAFFFIAFVSTTTKAFDPCPSLKPKSDGSDLSIIHIYGKCSPFDSPKPTSWATTVLNMAAKDPQRLTYLSNMVATKPVSSVPIAPGQVINVGNYVARVKIGTPGQLMFMVLDTSADTAWVPCTGCTGCSSTMFSQNMSTTYGSLDCATSECVQARGLSCPTAGPTNGNCLFNQSYGGDSSFSATLSRDSLQLANDIIPSYVFGCIGGVSGNSIPPQGLLGLGRGSMSLLSQSGSLYSGVFSYCLPSFRSYYFSGSLKLGPNGQPKTIKFTPLLKNPHRPSLYYVNLTGISVGRVNVPIAPELLDFNPNTGAGTIIDSGTVITRFVPAAYNAIKEAFRNQTQGPFSSLGAFDTCFSVTHENVAPKMTFHFTGLDIVLPMENTLIHSSAGTLACLAMASAPDNVNSVLNVIANLQQQNLRILFDVANSRVGIAREICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K429</accession>
    <name>A0A118K429_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_014818</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001579">
        <property type="protein sequence ID" value="KVI06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K429"/>
    <dbReference type="Gramene" id="KVI06827">
        <property type="protein sequence ID" value="KVI06827"/>
        <property type="gene ID" value="Ccrd_014818"/>
    </dbReference>
    <dbReference type="OMA" id="AHESAMS"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000233">
        <property type="entry name" value="RING-H2 finger protein ATL54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF19">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="323" mass="36402" checksum="ED11B43C21539EEE" modified="2016-04-13" version="1">MAINHRKLLSVSDSGETTDCSNCSTTCPYDCDYAQIYWPPEPPQLPPSTTTSHDSVTTHLSPYLIVILAVIGSAVLFISYYLIMIRYCTRFRLPSATQVNEELQDSMNEDHRPEIEHPIWYITTVGLQPAVINSITVVKFKKGDRLIDGTDCSVCLSEFEDDESLRLLPKCNHVFHIPCIDTWLRSHTNCPLCRVAVFSNNPNSISQPNDGNRNHGFGSNQITQMENAENNGDLGTNRVQESGNQENRRETGNGDGVEDGSKDDQDSKRRENETVVSLRRSFSMDLATEIVHMELNLSSEHMRDSRTGRMMMRSFSYGGRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4D6</accession>
    <name>A0A118K4D6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4D6"/>
    <dbReference type="STRING" id="59895.A0A118K4D6"/>
    <dbReference type="Gramene" id="KVI07335">
        <property type="protein sequence ID" value="KVI07335"/>
        <property type="gene ID" value="Ccrd_014256"/>
    </dbReference>
    <dbReference type="OMA" id="PTWNYKM"/>
    <dbReference type="OrthoDB" id="1909968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04051">
        <property type="entry name" value="C2_SRC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044750">
        <property type="entry name" value="C2_SRC2/BAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246:SF152">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246">
        <property type="entry name" value="INGRESSION PROTEIN FIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="338" mass="37897" checksum="A304107A7687E014" modified="2016-04-13" version="1">MSSRPRSKRLEITLISGHDLPPIARNLTTYAVAWLKPDHKLTTQVDHGGHTNPKWDHKFVFNLDRSFSISDTTTTVTFEIYNVGWLRDFLVGSAQVIVSNLVERRSKNHRPVTVQLRRPTGILQGVLNVGVNLIDRSNDNVGRNVVSRDPIGKIGVLENDEDRKMNDEKKLERSRSERTAKFGDFSVADEGGDGDGDRRVLSRSMSGCSVTQIGSVNSMMRPLPSEVVAALKNGMYSTGGDDIESYVFSAGTVEREPRNDKKDLNAMVAKWRHTVMNDKTPVVDNRRLISYDHEQRRKKGGRGRGGLFSCFGNIKGKEFSFICGNNEPAKRKKRKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4J3</accession>
    <name>A0A118K4J3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4J3"/>
    <dbReference type="STRING" id="59895.A0A118K4J3"/>
    <dbReference type="Gramene" id="KVI07605">
        <property type="protein sequence ID" value="KVI07605"/>
        <property type="gene ID" value="Ccrd_014042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33566">
        <property type="entry name" value="EN/SPM-LIKE TRANSPOSON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33566:SF6">
        <property type="entry name" value="PROTEIN DEFECTIVE IN MERISTEM SILENCING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="456" mass="51417" checksum="5247BE0DC0E1670E" modified="2016-04-13" version="1">MDSPSHKALMAQTQTLMMPMNEEGAETLSSLALIDLNTAAKDPMEIIGSFFRGDSLLFSSKKVEDDIESQGKKILQHEDNIKYFKNLIRKSLDPLIAQMQASLGNHPYRTKHMSEGHVHHLITRLEETVEHILQHDDKSAAAVICDLTRRYHQANPPPAPVAPILSDVLGVLATLGTVDDINLSTVLSEYLGLDTMLALVCKTYDGVKTLETYDEEGLINRTTGLYGLGASIGRNLEGRFHVICLEQLMPYGGEFMTNDPQRRLALIKPKLPNGESPAGFIAFAVNMIYIDSDYLSFVTENGHGLRETLYYKLLSHLQVYRTRKDMMQALPCISTGAISLDGGIIRRPHAMFSLGSTRKELDVSFGVCCGDDCFPSEQYIERENKIKKLKWKKERMMSDMEREEALLAHEKHKFEVKKEELLKFMAQQSLDQMQQQQQQQQQQQEEEGGEGRSTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K587</accession>
    <name>A0A118K587_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001098">
        <property type="protein sequence ID" value="KVI08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K587"/>
    <dbReference type="STRING" id="59895.A0A118K587"/>
    <dbReference type="Gramene" id="KVI08688">
        <property type="protein sequence ID" value="KVI08688"/>
        <property type="gene ID" value="Ccrd_012933"/>
    </dbReference>
    <dbReference type="OMA" id="FMARCIV"/>
    <dbReference type="OrthoDB" id="845076at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33874:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33874">
        <property type="entry name" value="RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="31132" checksum="7664DC4BC479775C" modified="2016-04-13" version="1">MGRITMETAKTVLEVAEVAFKAAEFSHEHHPHLPRNNEHQQKSDDDNQKKQVKEKELEALRLENQRLRGLLEQNLKLLQNISESPCLLEDCPPDLHSRIMDTVESPKFLSQLKTLHNNSVDGIPCRFSLNDASGMDLELDEILINFGLEEPSLWIWVSDEMVHGNVEEKSGIDNENYVVISQEQVVDGIANFMARCILLNPKAKNLAPEEMQKTLAKALGGKSKFEKILDIWQAGEMFYLMATWGLALAGLYQSRAVLRVAARGVHATSKVAMRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAR6</accession>
    <name>A0A124SAR6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005452">
        <property type="protein sequence ID" value="KVH88316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAR6"/>
    <dbReference type="STRING" id="59895.A0A124SAR6"/>
    <dbReference type="Gramene" id="KVH88316">
        <property type="protein sequence ID" value="KVH88316"/>
        <property type="gene ID" value="Ccrd_024152"/>
    </dbReference>
    <dbReference type="OMA" id="SIFEVIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF107">
        <property type="entry name" value="PLECKSTRIN DOMAIN, START DOMAIN, PROTEIN ENHANCED DISEASE RESISTANCE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="246"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="75431" checksum="2EF622D053AA66ED" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAX0</accession>
    <name>A0A124SAX0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005334">
        <property type="protein sequence ID" value="KVH88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAX0"/>
    <dbReference type="STRING" id="59895.A0A124SAX0"/>
    <dbReference type="Gramene" id="KVH88812">
        <property type="protein sequence ID" value="KVH88812"/>
        <property type="gene ID" value="Ccrd_025405"/>
    </dbReference>
    <dbReference type="OMA" id="NQICLRS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007789">
        <property type="entry name" value="DUF688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33671:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33671">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (DUF688)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05097">
        <property type="entry name" value="DUF688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="538" mass="60046" checksum="AD66F2A81D19B434" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBA3</accession>
    <name>A0A124SBA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBA3"/>
    <dbReference type="STRING" id="59895.A0A124SBA3"/>
    <dbReference type="Gramene" id="KVH90026">
        <property type="protein sequence ID" value="KVH90026"/>
        <property type="gene ID" value="Ccrd_007880"/>
    </dbReference>
    <dbReference type="OMA" id="TPFIPDE"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF33">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18926" checksum="2D4D0021F2EA5BB1" modified="2016-04-13" version="1">MGFPVGYTELFLPKLLIHILTLLGFIRKLISFVFRFVGLGDFLEPEFSTDPTRSEPVTHFHSVSAVLIREHLPVVKFSELVDPPESCAVCLYEFEAGDEIRRLTNCRHIFHRCCLDRWMDHDQKTCPLCRTPFIPDDLQDSFNERLWAASGIADYYGDSPLVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBL3</accession>
    <name>A0A124SBL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pathogenic type III effector avirulence factor Avr cleavage site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005085">
        <property type="protein sequence ID" value="KVH90982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBL3"/>
    <dbReference type="STRING" id="59895.A0A124SBL3"/>
    <dbReference type="Gramene" id="KVH90982">
        <property type="protein sequence ID" value="KVH90982"/>
        <property type="gene ID" value="Ccrd_006993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040387">
        <property type="entry name" value="RIN4/NOI4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF88">
        <property type="entry name" value="RIN4 PATHOGENIC TYPE III EFFECTOR AVIRULENCE FACTOR AVR CLEAVAGE SITE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32531" checksum="48C4EB84A4119C2F" modified="2016-04-13" version="1" fragment="single">SCIFWLLRLINSGEVVARSSNLLDHGRCRTLKLDNVHNLHPSMILRAQEETEVKNASRPKAETQVSREGDLKKSLDSPTHPKKVSTQPRVGTRSNTGSPMWERKVSSEGNNNAAPSTPGRSRLRQVTLGDETPDDSTAVPVFGDWDDSDPASAEGYSHIFNKVREEKHSGGGKSPRITSDDSYFHSQRPEAKKVNGVRLLSVGQKMISCWLFGCKVVDCTLLHIKLKGGVMYKHGVCKLPSFLLVKWYAELFLLSYRENLFPILPIVFAYDVCMLNLLNEKQKNKKARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE76</accession>
    <name>A0A124SE76_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003630">
        <property type="protein sequence ID" value="KVH99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE76"/>
    <dbReference type="STRING" id="59895.A0A124SE76"/>
    <dbReference type="Gramene" id="KVH99217">
        <property type="protein sequence ID" value="KVH99217"/>
        <property type="gene ID" value="Ccrd_022558"/>
    </dbReference>
    <dbReference type="OMA" id="MKLCRYW"/>
    <dbReference type="OrthoDB" id="665000at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33287">
        <property type="entry name" value="OS03G0453550 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33287:SF3">
        <property type="entry name" value="OS03G0453550 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="214" mass="25048" checksum="64020913A313A6DB" modified="2016-04-13" version="1">MAEVKDAQHHVVEIMVDGDHRISTIAAIQDHPLMEISESPGHLLLLKLWQREEDLFGRRIARKETRIDALTREIFQLCLFFFTFHGFFFTILFTSSHNSNSCRKWWIPILVSLSTCCMMILLVQMKLCRYWKVYGQLQMERTDSRALTRCIQELRMKGVSFDLSKEPGNGKRMKSSSVEIKWKPVTWCHQYLITIWLVSVMGLAVPVCRFMLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE77</accession>
    <name>A0A124SE77_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003631">
        <property type="protein sequence ID" value="KVH99207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE77"/>
    <dbReference type="Gramene" id="KVH99207">
        <property type="protein sequence ID" value="KVH99207"/>
        <property type="gene ID" value="Ccrd_022562"/>
    </dbReference>
    <dbReference type="OMA" id="WRAEGHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000016">
        <property type="entry name" value="nudix hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF30">
        <property type="entry name" value="NUDIX HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="37102" checksum="3FADB278E55106D4" modified="2016-04-13" version="1">MEQVTIGNCDERVQLLPAICDEYGGVVVELKEHMESDVFLTLLKTSMSQWTLQGKKGVWIKLPIHLANLVETTVKEGFWYHHAEPDYLMLVNWIPKTTSTLPLNASHRVGVGAIVLNDKQEIRSTEVAYDHHMETYQTVIFHSTPVLMLVVQEKSGILRGTGIWKIPTGIVEVVWLLEVVHYFANIPFSKTLIEFNLQGEDISAGVIREVVEETGIDTEFVEVLAFRQSHKAFFGKSDLFFVCMMRPLSFDIQIQELEIEAAQWMPLEEVAAQPFAQKTDSLMNRIMKLCKAKVEKDYSGFTPHPVTSYFSESPSYIYFNNTDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEE4</accession>
    <name>A0A124SEE4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_021918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003412">
        <property type="protein sequence ID" value="KVH99847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH99847">
        <property type="protein sequence ID" value="KVH99847"/>
        <property type="gene ID" value="Ccrd_021918"/>
    </dbReference>
    <dbReference type="OMA" id="MPVGMKE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF47">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="192"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="433"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="550"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="1517"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="1765"/>
            <end position="1894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH99847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2060" mass="235252" checksum="6879ADB1632D78B0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH03</accession>
    <name>A0A124SH03_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001380">
        <property type="protein sequence ID" value="KVI08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH03"/>
    <dbReference type="STRING" id="59895.A0A124SH03"/>
    <dbReference type="Gramene" id="KVI08038">
        <property type="protein sequence ID" value="KVI08038"/>
        <property type="gene ID" value="Ccrd_013596"/>
    </dbReference>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="600" mass="64918" checksum="A655F3DA1D76CD81" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SIB1</accession>
    <name>A0A124SIB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SIB1"/>
    <dbReference type="STRING" id="59895.A0A124SIB1"/>
    <dbReference type="Gramene" id="KVI12136">
        <property type="protein sequence ID" value="KVI12136"/>
        <property type="gene ID" value="Ccrd_009466"/>
    </dbReference>
    <dbReference type="OMA" id="KKSICND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="54313" checksum="634DFF37127CC022" modified="2016-04-13" version="1">MEWNLCLIGQKTTEPPQRHRRIDKLPPLLIKGEKGRRNQEYYEPAVVSLGPYHHNRPDLAQAEKYKLITLEEFSFSSGRKIDYLYNKVFEVVHDARKCYIDGSTDDYNDEEFNRMMLRDACFVLFFIECLSLSNKKVMLNNEYLGALGFANVVRDIFLLENQIPFVVLEVLLDLRFDDKGEKVLNGFFNYLNYGELIPREELKVLEDEYPLHLLELYRSYFISLSRFGLSSTISSRWRKWTKKTDAEEDYNYVKRNRSFASVMELKAKGIFVKCSYDESTNEDIKFHSRCCYGELELVRRAVSSNSKAIYLNMIAYEMCPHNPNDFRVSTYIRVMKSLIVHPDDVKELRNSSILLHTLGRDEEVVKMYDEIEVPAVNLYMFNQLRRGIEKHCKNKYKTWAAELITVYFSSPWKTVALLVASAILFTTFLQTYFTIRPLPDDSNENIIKLLRRCARYKPPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SSR0</accession>
    <name>A0A103SSR0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007386">
        <property type="protein sequence ID" value="KVG93630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SSR0"/>
    <dbReference type="STRING" id="59895.A0A103SSR0"/>
    <dbReference type="Gramene" id="KVG93630">
        <property type="protein sequence ID" value="KVG93630"/>
        <property type="gene ID" value="Ccrd_026083"/>
    </dbReference>
    <dbReference type="OMA" id="ELVEYWM"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000003">
        <property type="entry name" value="Probable disease resistance protein At5g66910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF167">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="159"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="407"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="9">
        <location>
            <begin position="798"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVG93630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="961" mass="110065" checksum="87F3B1C99DF2E382" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UVM7</accession>
    <name>A0A103UVM7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006851">
        <property type="protein sequence ID" value="KVH42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UVM7"/>
    <dbReference type="STRING" id="59895.A0A103UVM7"/>
    <dbReference type="Gramene" id="KVH42631">
        <property type="protein sequence ID" value="KVH42631"/>
        <property type="gene ID" value="Ccrd_025753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="34660" checksum="4D79FD09BB5C5D0F" modified="2016-04-13" version="1" fragment="single">FRSPSPSAIIPLLPRSSFPPSASTVAVRFRLLWCKLPGCNLKASPHIESRLKTLKKHCDAITNMKDAFENCDQSSLESSSSPACIYLKPRVVAIGPLHKEDEELQDIESHKVTYLLDLFLRLPSMPNQKMDECIQRVYAKVEQIRACYAGEMKDYDDGEVAKMMVIDGCFILEFILRVRNHNHPDDDPIFYNKLVYINVAYDLVLLENQIPFFVLQDIFKCTILEFSPSSSLQSLVFSFLRPIYPFDKSYVTNINDGVDTSYDHILGLLQKFCQPADAMPSEFSVTRFHSVEELTVAGVNFKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WQL8</accession>
    <name>A0A103WQL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006506">
        <property type="protein sequence ID" value="KVH76723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103WQL8"/>
    <dbReference type="Gramene" id="KVH76723">
        <property type="protein sequence ID" value="KVH76723"/>
        <property type="gene ID" value="Ccrd_025534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044954">
        <property type="entry name" value="Ribosomal_uS3m_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35928">
        <property type="entry name" value="RIBOSOMAL PROTEIN S3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35928:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="5">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH76723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="31287" checksum="CFB0449914D4DF31" modified="2016-04-13" version="1">MNESPDEKVMAKDKVMELIEKFIDLGGIGELIKGIEMMIEIILRNRRIPYGYNFYLNEVKKMRSLLSNRTKTNTLIESVKIKXVYQSASPITQDISVQPRNKTRSFRSIFSQIVKDIRLVMKKGVEGIRICCSGRSEGAEIARTECGKYGKTSSNVFNQKIDYAPAEVSTRYGISDVVGVANRTVHDLVLEDMALKVVELVVFHIEPLKQRVEISLLPGNLQKSEWEEEKGNXTGWIARVSTGQIPFEMDGVSLSNARQAATLAAHKLCSSTKFVQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCU3</accession>
    <name>A0A103XCU3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal-associated domain, HMA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005420">
        <property type="protein sequence ID" value="KVH88395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCU3"/>
    <dbReference type="STRING" id="59895.A0A103XCU3"/>
    <dbReference type="Gramene" id="KVH88395">
        <property type="protein sequence ID" value="KVH88395"/>
        <property type="gene ID" value="Ccrd_023908"/>
    </dbReference>
    <dbReference type="OMA" id="DLHCIGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044258">
        <property type="entry name" value="HIPP09-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47066">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47066:SF1">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25683" checksum="47B514F568835AB1" modified="2016-04-13" version="1">MEGKEERKKTIESEPKAVPSPMVLSVDLHCIGCAKKIEKSLLQIRGVAGVKVDMVKNQVTVKGVVEPEAVCNKIMEKIKTSAKVLSPVPVPDPDPDPDPEKVVDSDHGCSSHDVELNVNMHCEACAQQLRRKILKMKGVSKVETEVRCGKVRVMGTMDGKKLVEYVYRRTKKQAKIVPHPQPHKAKEEGEVVEKEDEKDGDEERMMPAVNYLMMPAPQLFSDENPNACCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD53</accession>
    <name>A0A103XD53_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005388">
        <property type="protein sequence ID" value="KVH88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD53"/>
    <dbReference type="STRING" id="59895.A0A103XD53"/>
    <dbReference type="Gramene" id="KVH88519">
        <property type="protein sequence ID" value="KVH88519"/>
        <property type="gene ID" value="Ccrd_026628"/>
    </dbReference>
    <dbReference type="OMA" id="FKVWQKR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33780">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33780:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118701" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11928" checksum="844E4EFF1E92FAFB" modified="2016-04-13" version="1">MTQISLRFLLLLSLISAQFFSGFSDDSNSKNGTKVDAHSSSSRTGSIILIICIALVAVVGLSFFLFRLWQKKKRDEQYARLLKLFEQDDELELELGLRVNDEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD95</accession>
    <name>A0A103XD95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:Glycoprotein Glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_026353</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005364">
        <property type="protein sequence ID" value="KVH88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XD95"/>
    <dbReference type="Gramene" id="KVH88595">
        <property type="protein sequence ID" value="KVH88595"/>
        <property type="gene ID" value="Ccrd_026353"/>
    </dbReference>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118692" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="91"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="400"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="529"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="791"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1339"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1424"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1560" mass="174348" checksum="D675579E18DDFDA2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEZ6</accession>
    <name>A0A103XEZ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_008542</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005208">
        <property type="protein sequence ID" value="KVH89491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEZ6"/>
    <dbReference type="STRING" id="59895.A0A103XEZ6"/>
    <dbReference type="Gramene" id="KVH89491">
        <property type="protein sequence ID" value="KVH89491"/>
        <property type="gene ID" value="Ccrd_008542"/>
    </dbReference>
    <dbReference type="OMA" id="NNELKPM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000653">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="16">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH89491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="474" mass="53419" checksum="9624A89E00B60F07" modified="2016-04-13" version="1">MASTTSSPSPSPSTTRKEAQGLLLRRFEIGHVLGHGSFGKVYVARNIKTNELVAIKVIDKEKVMKGGLISHIKREISILRRVRHPNIVRLFEVMATKTKIFFVMEYVKGGELFSKVAKGRLTEDVARKYFQQLISAVGFCHARGVYHRDLKPENILLDEDGDLKVSDFGLSAISEQMCGDGLFHTFCGTPAYVAPEVLGRKGYEAAKVDIWSCGVILFVLMAGYLPFRDQNIMVMYKKIYKGQFRRPRWFSPELSRLLKRLLDTNPETRIRIPEIMEDKWFKKGFKHIKFYVEDDDMISTVKDRGTEDCIDYFSDQSLYSESESEMEVKKRSVSGNFPRPMSLNAFDLISFSPGFSLSGLFEDGTEESRFVTAAPVSSIISKLEEVAKVVSFSVRRKDCRISLEGSREGVKGPLTITVEIFELTPNLRVIEVKKKAGDKSEYDEFCANKLGPGLQPLVLTGSSEPSSHLPADNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFN5</accession>
    <name>A0A103XFN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_008207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005138">
        <property type="protein sequence ID" value="KVH89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFN5"/>
    <dbReference type="Gramene" id="KVH89792">
        <property type="protein sequence ID" value="KVH89792"/>
        <property type="gene ID" value="Ccrd_008207"/>
    </dbReference>
    <dbReference type="OMA" id="HCHHEER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF132">
        <property type="entry name" value="CALCIUM-DEPENDENT CHANNEL, 7TM REGION PHOSPHATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="92"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="318"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="417"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="801" mass="90756" checksum="A4D295373C86DFBD" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFN9</accession>
    <name>A0A103XFN9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005127">
        <property type="protein sequence ID" value="KVH89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFN9"/>
    <dbReference type="Gramene" id="KVH89885">
        <property type="protein sequence ID" value="KVH89885"/>
        <property type="gene ID" value="Ccrd_008116"/>
    </dbReference>
    <dbReference type="OMA" id="SHVGNDQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF136">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="42387" checksum="453D8F996E8DF0B5" modified="2016-04-13" version="1">MDLYSSKRAVGWAAASRKGSGSGTRDTDCSRDEAAQFCNRLGCSGRLNYTKHTRSSLLNQPKPFRSSSRPSHSKEVASSLINVKKPLQESRKKLSSGTETSSTHSSSVSEESRIQVLNASAKLKSKSRGTESNKVGFTPVGRTVEMGSSNTKIRKVYGQKSGLPNQDAQITSFDSGRRRNVVKKRLTEGETGSSARGKKISGPSSDEGSSISDSRRSTNWTACSGSNVSSVRTRRSVNVDLSTRCIHQLHRNNPSPVQSTRVTPDMSQTEICWLSEETSSNGSTPNSGCTSSDTLSSMMPVASTEQSVGHFNDRHCSGRYNVDAIANVLLALERIEQDEELTYEEEFMAGDEIGRLSCAHGYHAVCINQWLQLKNWCPICKASAKPSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFQ9</accession>
    <name>A0A103XFQ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_008061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005123">
        <property type="protein sequence ID" value="KVH89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFQ9"/>
    <dbReference type="Gramene" id="KVH89940">
        <property type="protein sequence ID" value="KVH89940"/>
        <property type="gene ID" value="Ccrd_008061"/>
    </dbReference>
    <dbReference type="OMA" id="LLMEHMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF2">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="39776" checksum="CA2DC741AFEAF53F" modified="2016-04-13" version="1">MGVSALGLQRKNQTSKVPLLMERTESHTESEHVIDISNSNEASSSSSTLARPVSGSNVRQNEDLLSTNVQAPVFQHSFSTTNGTNSRNTSFARRGNGHGRRRSPLNSGYWISVELVITVSQIIAAIVVLSLSRHEHPHAPLFTWVIGYASGCVVTLPLLFWRFHNRNYGSNQEPSQARQSSTPGSLSAIASSFTSPSNGRISEGDTRNTTGTSSRRFTLGSLGARIKVLAEYFKMGLDCFFAVWFVVGNVWIFGGATTESINSLPTYKFKKNKHTNDKETNLGTCEGGVVAAGTEKERVISGEDAYANDDELRELPCSHFFHTDCVDKWLKINASCPLCKTEVGETILSSLTEATASLRRSAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHW8</accession>
    <name>A0A103XHW8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005081">
        <property type="protein sequence ID" value="KVH91071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHW8"/>
    <dbReference type="STRING" id="59895.A0A103XHW8"/>
    <dbReference type="Gramene" id="KVH91071">
        <property type="protein sequence ID" value="KVH91071"/>
        <property type="gene ID" value="Ccrd_006911"/>
    </dbReference>
    <dbReference type="OMA" id="IDINSMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF130">
        <property type="entry name" value="CYTOCHROME B5-LIKE HEME_STEROID BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12407" checksum="EC512CC1B8D36F9A" modified="2016-04-13" version="1">MMVYDITPFLDDHPGGDEVLVLATKKDATEDFEDVGHSQNARNMLTEYYVGDIDINTMPQKGQYKKTASNSGSGSKSGSGSSSNIMVMLVLPILMLVLAYGLYYFAKKDKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIE7</accession>
    <name>A0A103XIE7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication protein A 70 kDa DNA-binding subunit B/D first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005067">
        <property type="protein sequence ID" value="KVH91232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH91232">
        <property type="protein sequence ID" value="KVH91232"/>
        <property type="gene ID" value="Ccrd_006761"/>
    </dbReference>
    <dbReference type="OMA" id="CEITSLC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04480">
        <property type="entry name" value="RPA1_DBD_A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="1">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="314" mass="35312" checksum="CC727CE69856ECFC" modified="2016-04-13" version="1">MEFVGLQNLVLDNESWVVKIRICRLWESLNTKRNGELISLDMVVIDENGSLMXAXVRKNLVNKFNHLLKEGNVYILKNFKVVENSGAFKVIDSKLKIMFTLLTKVEKXDTYVXSIPMHGFQLASEKTVNDRLNDDNILTDIIGCLTAVGDVETVRGGFRKRDLEIISELKVNHIDGVYKCASCNVAYKNALTLFKLHLSVRDDTGVVNCVVLHKLAERMVDSSPLKLLNKSDPDKDNLPCEITSLCGQKFVFCLQLSDYNIKHGSNIFTVSKEMASSDMKNLDDIGGTPPCNNATRTTTRKRKFIVNDDDEAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJW5</accession>
    <name>A0A103XJW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004850">
        <property type="protein sequence ID" value="KVH92120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJW5"/>
    <dbReference type="Gramene" id="KVH92120">
        <property type="protein sequence ID" value="KVH92120"/>
        <property type="gene ID" value="Ccrd_005848"/>
    </dbReference>
    <dbReference type="OMA" id="RTIDCND"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF70">
        <property type="entry name" value="TRANSFERASE, CHLORAMPHENICOL ACETYLTRANSFERASE-LIKE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="48000" checksum="1E577C2C69C9EADA" modified="2016-04-13" version="1">MAIDIVKQSSKFIKPATPTPPNLRHFRIGFIDEFAPSANVSVVLFFSINGDRNPKFIAQLGESLQTTLIRFYPLAGRYAAETRTIDCNDQGAEFMHAKVNIKLEAFLDSEVNVKLVDKFLPREIGESGLITDPILAIQVTTFECGGVALGVSISHKIADASTLSTFLNEWAVINREEKRIELTGSCRFNAASLFPSRGVPALDLGFSRSIRDDDMQSKYVTKKLSFSESEISNLKEKAMLINGRNGTPQWSKVQLVSAIILKSFICVDRAIRDDPRDTILIHPINLREKTASLIPKDSCGNLWGILATECGVVEATEALADLLRDSIKNTISNYLKVSHDDEGEQTMVLNSILNVGQIPQTANVIWMSSWCKFPFYEVDFGFGKPIWANPGGMPVKNSACLMDGVGGDGVEAYVCMEPKDVPYFEESLEIKVCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK61</accession>
    <name>A0A103XK61_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_005766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004836">
        <property type="protein sequence ID" value="KVH92188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK61"/>
    <dbReference type="Gramene" id="KVH92188">
        <property type="protein sequence ID" value="KVH92188"/>
        <property type="gene ID" value="Ccrd_005766"/>
    </dbReference>
    <dbReference type="OMA" id="MFPIITY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000632">
        <property type="entry name" value="RING-H2 finger protein ATL73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044602">
        <property type="entry name" value="ATL10/ATL72-79-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905:SF18">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH92188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24305" checksum="0D8DC1EB6005F926" modified="2016-04-13" version="1">MSTTSTILFHDALGHFYSRKLLLQTLSEHPAAATTMMAASSPSSSYTVHSNFDSNVVMVLSVLLCALICSLGLNSIIRCVLRCTNYVGSESSTGQESTSVRLANTGIRKKALKTFPTVSYWEGLQLPGLDKECVICLGDFSKGERVKILPKCNHGFHVRCIDKWLSSHSSCPTCRHSLLDTCQKILTGGNYPSSQPEAQGPSSTTTISIMPLQHEGLLRNYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLF7</accession>
    <name>A0A103XLF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLF7"/>
    <dbReference type="STRING" id="59895.A0A103XLF7"/>
    <dbReference type="Gramene" id="KVH92975">
        <property type="protein sequence ID" value="KVH92975"/>
        <property type="gene ID" value="Ccrd_005028"/>
    </dbReference>
    <dbReference type="OMA" id="TQIFFAG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098:SF36">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56491" checksum="47EE7FCECE51E609" modified="2016-04-13" version="1">MMEEDGEETPRTPFWIQSTTNLRRGELYRRRASSLFFNSGVLIILLLLFAIISMVYIIPSLISFSSQIFRPNLVKKSWDSINLVLVLFALAFGFLGRNINNDQKSRFDNGFDRSSSDFSTAPTVSTPPPIIQHQWYDFPEQPIGGLRRHRSTSSYPDLRELSPPWNHQGAGSWRFSDDTHLNSHRSLDSDRYYFRREQDPDTKDVIHVDSVVDLPKEDSYAPPPPPSPPPPASKDESYSPPQQLPSPPSLPPQPQPPAMGRKNLSRTYHNAAEYAGEKSRSSEFSEVFSPETAPPPPPVTVRSLPPFQDSDRKGETNIRKRGKGERRRARSSEPRKMVTPEPSSPPPILPIIQDSDQKTGGVERKRTVPPFVTEKPRVPLNMSFINTIDDSSSGGESPMGRIPPPPPMPPFKMPDWKFAVEGNYVRVQSTLSSGSVSPDGDEAQSPLSAVASPLFCPSPDVDTKADSFIARFRAGLKLEKINSFNQNQGLRMSNLGPGPGPSDHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMF0</accession>
    <name>A0A103XMF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004763">
        <property type="protein sequence ID" value="KVH93466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMF0"/>
    <dbReference type="Gramene" id="KVH93466">
        <property type="protein sequence ID" value="KVH93466"/>
        <property type="gene ID" value="Ccrd_004480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="2">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="61" mass="6845" checksum="DE081579E4B911DA" modified="2016-04-13" version="1">MDEEFSNPMQSCGATQRRKGVRGLRGMRFDIEFGRSMVKMGNTDLKTGSEGEIRRVCTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNP0</accession>
    <name>A0A103XNP0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">indole-3-pyruvate monooxygenase</fullName>
            <ecNumber evidence="9">1.14.13.168</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>indole-3-pyruvate + NADPH + O2 + H(+) = (indol-3-yl)acetate + CO2 + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:30854"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.168"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Plant hormone metabolism; auxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.168" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01004586">
        <property type="protein sequence ID" value="KVH93899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNP0"/>
    <dbReference type="STRING" id="59895.A0A103XNP0"/>
    <dbReference type="Gramene" id="KVH93899">
        <property type="protein sequence ID" value="KVH93899"/>
        <property type="gene ID" value="Ccrd_004045"/>
    </dbReference>
    <dbReference type="OMA" id="CWRVKTQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103075">
        <property type="term" value="F:indole-3-pyruvate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009851">
        <property type="term" value="P:auxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF85">
        <property type="entry name" value="FLAVIN-CONTAINING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0073">Auxin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="43092" checksum="61A483548D697E8A" modified="2016-04-13" version="1">MEEYAKRVHDPYFQPQIAASTTGSGSSMASRVWVPGPVIVGAGPSGLAAAACLKNHGVPVLILERSCCIASLWKMKTYDRLCLHLPKQFCQLPLLPFPKDFPTYPTKQQFLAYLEGYARKFDLKPVFNTVVVRAEYDGGCEVWRVKTKMVEYVCRWVIVATGENAEEVVPKIEGMNEFIGPILHTSSYKSGDCFENKKLHVLPQEMLGRSTFGLSMWLLKWFPIRVVDRILLFASHFMIGDTDRLGLNRPKLGPLELKNISGKTPVLDVGTLAKIRSGDIKVPISFFLSFFTRVYPGIKKLACNTVEFVDGRMEKFDAIILATDGFPTKPFPEGWKGECGLYAIGFTKRGLLGTSIEAARIAEDIARQWTTDTKHFKSFRHQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ79</accession>
    <name>A0A103XQ79_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SCAR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein WAVE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004507">
        <property type="protein sequence ID" value="KVH94896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XQ79"/>
    <dbReference type="Gramene" id="KVH94896">
        <property type="protein sequence ID" value="KVH94896"/>
        <property type="gene ID" value="Ccrd_003044"/>
    </dbReference>
    <dbReference type="OMA" id="ACSEMQC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1361"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1381" mass="152109" checksum="6C35D5B1C200D6AF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQN3</accession>
    <name>A0A103XQN3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase</fullName>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01004399">
        <property type="protein sequence ID" value="KVH95101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQN3"/>
    <dbReference type="STRING" id="59895.A0A103XQN3"/>
    <dbReference type="Gramene" id="KVH95101">
        <property type="protein sequence ID" value="KVH95101"/>
        <property type="gene ID" value="Ccrd_002837"/>
    </dbReference>
    <dbReference type="OMA" id="SEPWVND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="274"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="969"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131046" checksum="64EB01BA5EE5F36D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTD7</accession>
    <name>A0A103XTD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004277">
        <property type="protein sequence ID" value="KVH96510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTD7"/>
    <dbReference type="STRING" id="59895.A0A103XTD7"/>
    <dbReference type="Gramene" id="KVH96510">
        <property type="protein sequence ID" value="KVH96510"/>
        <property type="gene ID" value="Ccrd_001404"/>
    </dbReference>
    <dbReference type="OMA" id="MRSETHP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000678">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein MRL1 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000542">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein MRL1, chloroplastic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053303">
        <property type="entry name" value="Chloroplast_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47935">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN MRL1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47935:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN MRL1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="515"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="689"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="759"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="794"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123988" checksum="99574DC8094B8529" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU16</accession>
    <name>A0A103XU16_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-specific protease family C19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004121">
        <property type="protein sequence ID" value="KVH96888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU16"/>
    <dbReference type="STRING" id="59895.A0A103XU16"/>
    <dbReference type="Gramene" id="KVH96888">
        <property type="protein sequence ID" value="KVH96888"/>
        <property type="gene ID" value="Ccrd_001020"/>
    </dbReference>
    <dbReference type="OMA" id="KAMVWAV"/>
    <dbReference type="OrthoDB" id="1899156at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040339">
        <property type="entry name" value="At1g16860-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33709">
        <property type="entry name" value="OSJNBA0035M09.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33709:SF17">
        <property type="entry name" value="UBIQUITIN-SPECIFIC PROTEASE FAMILY C19-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45030" checksum="5398F15028A1EF81" modified="2016-04-13" version="1">MGSRIPSHQLSNGLYVSGRPEQLKDRQPTIGSRAIPYTGGDVNKSGELGKMFDIPVAEHPPPVLKPHRASSSSQQSSGSLRSGPVSKRASGSGPIVALQPTGLITSGQLELSGGRRSGQLEPTAAAISSGKTVYGSSVTTLGYDDVRLGFRKLMWVLLVMAVMGLMVGAFLTVAVKKPVILVAAAAVLVPAMILILWNCVWKKRGLLAFFRKYPNAELRGAIDGQFVKVTGIVTCGSIPLESSFQKVARCVYVSTDLYEYNGFGGKSSNAKHRCFSWGCTNSEKYVADFYISDFQSGLRALVKAGYGAKVAPFVKETTVVDISKENRELSPTFLRWLADRSLSSDDRVMRLKEGYIKEGSTVSVMGVVRRHENVLMIVPPTEPMSTGCRWGCGLLPTYVEGLVLTCDENQNADVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUP0</accession>
    <name>A0A103XUP0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003849">
        <property type="protein sequence ID" value="KVH97199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XUP0"/>
    <dbReference type="Gramene" id="KVH97199">
        <property type="protein sequence ID" value="KVH97199"/>
        <property type="gene ID" value="Ccrd_000699"/>
    </dbReference>
    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000005">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="10">
        <location>
            <begin position="618"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1811" mass="202002" checksum="4D28E6AEAC235E30" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUR2</accession>
    <name>A0A103XUR2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003845">
        <property type="protein sequence ID" value="KVH97277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUR2"/>
    <dbReference type="STRING" id="59895.A0A103XUR2"/>
    <dbReference type="Gramene" id="KVH97277">
        <property type="protein sequence ID" value="KVH97277"/>
        <property type="gene ID" value="Ccrd_000623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH97277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23347" checksum="674E7C99522C4089" modified="2016-04-13" version="1" fragment="single">HREEPVFSYIRVLGFSSILFQHSSTGFRQKEMGRAKKGPKFAVMKKLASHKAIKQHKEEVLNPNKKDLTKEKLPRNVPYVSSALFFTYNTALGPPYRVLVDTNFINFSIQNKLDLEKGMMDCLYAKCTPCITDCVMAELEKLGQKYRVALSSKNMTFGRSCMLSMIEFYVTRRTDLVEIAHYCHPERLLFFKNVLSFYLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUU8</accession>
    <name>A0A103XUU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003845">
        <property type="protein sequence ID" value="KVH97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUU8"/>
    <dbReference type="STRING" id="59895.A0A103XUU8"/>
    <dbReference type="Gramene" id="KVH97279">
        <property type="protein sequence ID" value="KVH97279"/>
        <property type="gene ID" value="Ccrd_000625"/>
    </dbReference>
    <dbReference type="OMA" id="CGWWMHE"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF28">
        <property type="entry name" value="DELTA(8)-FATTY-ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="469" mass="53202" checksum="20B3C1DE99B953B1" modified="2016-04-13" version="1">MVCEDLTMVSPSFPVIEVLNSMADGKKYITSEELGKHNKPGDLWISIQGKVYNVTEWAKEHPGGDIPLLNLAGQDVTDAFIAFHPGTAWKHLDKLYTGYHLKDYQVSDVSRDYRKLASEFSKAGMFDKKGHGVIYSLCFVSLLLSGCVYGVLYSTSFWVHMFAGALLGLAWMQIAYLGHDAGHYQMMATRGWNKFAGIFIGNCITGISIAWWKWTHNAHHIACNSLDYDPDLQHLPMLAVSSKLFNSLTSVFYGRQLTFDPLARFFVSYQHYSYYPIMCVARVNLYLQTLLLLISKRKVPDRGLNILGTLVFWTWFPLLVSCLPNWPERVAFVLVSFCVTGIQHVQFTLNHFAANVYIGAPKGNDWFEKQTSGTIDISCSSWMDWFFGGLQFQLEHHLFPRLPRCHLRSISPIVRDLCKKHNLPYTSLSFYDANVTTLKTLRTAALQARDVANPGPPQNLVWEAFNTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVC0</accession>
    <name>A0A103XVC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003825">
        <property type="protein sequence ID" value="KVH97563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVC0"/>
    <dbReference type="Gramene" id="KVH97563">
        <property type="protein sequence ID" value="KVH97563"/>
        <property type="gene ID" value="Ccrd_000318"/>
    </dbReference>
    <dbReference type="OMA" id="PDSFIVM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH97563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="31566" checksum="4BF1AEB88F831150" modified="2016-04-13" version="1" fragment="single">MGSETATQLPLIDFSKIYLHQSTPDDWNSVKIQVHEALTEYGFFRASMAGMSPEFRSSLFGSLDQLFDLPMETKLKSISDKPFHGYIGHSPTMPLYESMAVPDAPVAGEVEAFTNFFWPHGNPLYWLDRTVRKMVIESMGLEKYSDDHMDSTKHLLRVAKYRGPDTDESITGLTSHIDKTTLSILYQNEVAGLELETKSGEWIRVKQSPDSFTVFVGEETRYSLGLFSVPKPSYITRVPHELVTEEHPLLFNPFDYDEFLKHMFTGKIGANADALDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVW6</accession>
    <name>A0A103XVW6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Remorin, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVW6"/>
    <dbReference type="STRING" id="59895.A0A103XVW6"/>
    <dbReference type="Gramene" id="KVH97859">
        <property type="protein sequence ID" value="KVH97859"/>
        <property type="gene ID" value="Ccrd_000058"/>
    </dbReference>
    <dbReference type="OMA" id="QEPRIHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471">
        <property type="entry name" value="OS02G0116800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471:SF99">
        <property type="entry name" value="REMORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="31606" checksum="2B36CAC575C52556" modified="2016-04-13" version="1">MRSIEDKGSLNLASTHEIPGGGNGGGNFEFQKGSGANRGSHHHRTALGKPTPSKWDDAQKWLVNLSRVGDKNHSNTEPRDSNADDRRLIAPVPKKDYPSSEDEEQTDANLIQYGAIETKKVDFGDSMCVRSICVRDMGTEMTPMASQEPSRSATPVRATTPAARSPIASGSSTPVRPCPNAASTVAPKVDASGTTRFGRESEETYVENVVETRNPNPDSKLDPLETRAMAWDEAERAKYMARIAEEKRAKAEAILNEKAIKTCERADYIRRTGHLPSSFSIKLPSCCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVZ7</accession>
    <name>A0A103XVZ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lipoxygenase</fullName>
            <ecNumber evidence="14">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_023856</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; oxylipin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="14"/>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVZ7"/>
    <dbReference type="STRING" id="59895.A0A103XVZ7"/>
    <dbReference type="Gramene" id="KVH97896">
        <property type="protein sequence ID" value="KVH97896"/>
        <property type="gene ID" value="Ccrd_023856"/>
    </dbReference>
    <dbReference type="OMA" id="PFDPRPM"/>
    <dbReference type="UniPathway" id="UPA00382"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01751">
        <property type="entry name" value="PLAT_LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.60:FF:000002">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.372.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020833">
        <property type="entry name" value="LipOase_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042057">
        <property type="entry name" value="Lipoxy_PLAT/LH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00711">
        <property type="entry name" value="LIPOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="15">
        <location>
            <begin position="97"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="16">
        <location>
            <begin position="223"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH97896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="764" mass="86694" checksum="31395C0CA2B2E6FE" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWD6</accession>
    <name>A0A103XWD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWD6"/>
    <dbReference type="STRING" id="59895.A0A103XWD6"/>
    <dbReference type="Gramene" id="KVH98120">
        <property type="protein sequence ID" value="KVH98120"/>
        <property type="gene ID" value="Ccrd_023659"/>
    </dbReference>
    <dbReference type="OMA" id="FQHNEFA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000008">
        <property type="entry name" value="Tryptamine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="41320" checksum="C3C526E4026DBC5F" modified="2016-04-13" version="1" fragment="single">MEGNGNESHGVELVVTQIGDSTLVQPYTETEKGFYFLSNLDQNIAVIVRTIYCFKSEEKGNETAVEVIRDALSRVLVYYYPAAGRLAISPEGKLIVDCSGEGVVFVEAEANCAIEDIGDNTKPDPVTLGKLGLIIFSRFLLEIARGSPLQLPPFLDRTILTARNPPIIDFPHYEFAEIEDVSDSGNLYKEEIAYRSFCFSPDDLHHLKIEATAAGEIPTCTTFEALSAFVWRARTKALKMKPDQKTKLLFAVDGRSRFEPPLPEGYSGNGIVLTNSICLAGDQVSNPLSFTVKLVHNAVKLVTDGYMRSAIDYFEVTRARPSLAATLLITTWSKLQFHAHDFGWGEPVLSGPVALPEKEVILFLSHGKQRKSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX13</accession>
    <name>A0A103XX13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_023326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003796">
        <property type="protein sequence ID" value="KVH98451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XX13"/>
    <dbReference type="Gramene" id="KVH98451">
        <property type="protein sequence ID" value="KVH98451"/>
        <property type="gene ID" value="Ccrd_023326"/>
    </dbReference>
    <dbReference type="OMA" id="QNEIRRM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050193">
        <property type="entry name" value="Cytochrome_P450_71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47956">
        <property type="entry name" value="CYTOCHROME P450 71B11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47956:SF49">
        <property type="entry name" value="CYTOCHROME P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH98451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="476" mass="54224" checksum="DD833975B447CC6F" modified="2016-04-13" version="1">MILTSNMISRVAFRKRPYTFDGEQKEVRRFHQLLLECQALLVTFYYRDHFPLMGWLDKLDGSIARLENTFNDLDEIYQKLIDEHLKRNRPDKVQDDMVDILLKLKQEYSNSSVELTFDHIKAVLTNILLGGTETSASVVVWAMTLLIKNPESLKKAQQEVRNVIGKKGKVQEDDLHKLHYLKAVIKETLRLYPVAPLLVPRESRDRCXLDGYEIPXGTLVYVNAWAVGRDPKRWENPEEFKPERFMGSSIDYKGTDFELIPFGSGRRVCPRMSLGVATVELALSNLVYAFDWELPDGEKDIDTSATLGIVSHKKNALRLVAEVRDYGCKIIKETLRLYPVAPLLVPRESRDRCILDGYDIPKGTLVHVNAWAVGRDPNCWENPEEFKPERFMGSNIDYKGTDFELIPFGSGRRVCPGMSLGVATVELSLSNLVYAFDWELPDGEKDTDTSATLGIVSHKKNALRLVAEVHDYGCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYP2</accession>
    <name>A0A103XYP2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003607">
        <property type="protein sequence ID" value="KVH99348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYP2"/>
    <dbReference type="Gramene" id="KVH99348">
        <property type="protein sequence ID" value="KVH99348"/>
        <property type="gene ID" value="Ccrd_022424"/>
    </dbReference>
    <dbReference type="OMA" id="DRIDNIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol transfer protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF28">
        <property type="entry name" value="CRAL-TRIO LIPID BINDING DOMAIN, CRAL_TRIO DOMAIN, CRAL_TRIO DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="40651" checksum="10B796A8A6CE5DD4" modified="2016-04-13" version="1" fragment="single">ELCFVHLAICSLPDIFVEAEQQTKRSSLPFPRRPAHTLFPSVVVPLFTTPMFRRRGSSQQQQDQEHHEQQPEAKAAVGLLSLQLNELRVALGPLSGRNLIYCTDACLKRYLEARNWNVDKAKKMLEETLIWRSTYKPEEIRWQEVAVEGETGKLFRANFRDRFGRSILIMKPGLQNTTSMDTQIRHLVYMMENAILNLPDGQEEMVWLIDFTGLSFSINVPIKTARDTVTILQNHYPQRLAVAILYSPPRIFEAFWKIVKYFLDPKTFQKVKFVYPKNKESLELIKSFFDVDNLPTEFGGKATMKYDHEDFSKLMAQDDVKAAKFWGFDEKMASAATTGNHVAGAAVAPEPESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYQ8</accession>
    <name>A0A103XYQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Coatomer, alpha subunit, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_022455</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003618">
        <property type="protein sequence ID" value="KVH99314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYQ8"/>
    <dbReference type="STRING" id="59895.A0A103XYQ8"/>
    <dbReference type="Gramene" id="KVH99314">
        <property type="protein sequence ID" value="KVH99314"/>
        <property type="gene ID" value="Ccrd_022455"/>
    </dbReference>
    <dbReference type="OMA" id="MCARWHP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF42">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="119"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="405"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="16">
        <location>
            <begin position="594"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH99314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="996" mass="111515" checksum="0B153028C0D68DFB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZW3</accession>
    <name>A0A103XZW3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVH99947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZW3"/>
    <dbReference type="STRING" id="59895.A0A103XZW3"/>
    <dbReference type="Gramene" id="KVH99947">
        <property type="protein sequence ID" value="KVH99947"/>
        <property type="gene ID" value="Ccrd_021754"/>
    </dbReference>
    <dbReference type="OMA" id="METYWGN"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF22">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="16030" checksum="7F2984B046A455A2" modified="2016-04-13" version="1">MGTLNMLGLAKRIRARFLITSTSEVYGDPLEHPQKETYWGHVDGLMALMEGDHIGPFNLGNPGEFTMLELAEVVKEIIDSKAAIEFRENTADDPQKRKPDISKAKELLKWEPKITLREGLPQMASDFRSRILKEDEGEFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0F2</accession>
    <name>A0A103Y0F2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0F2"/>
    <dbReference type="STRING" id="59895.A0A103Y0F2"/>
    <dbReference type="Gramene" id="KVI00252">
        <property type="protein sequence ID" value="KVI00252"/>
        <property type="gene ID" value="Ccrd_021491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="16832" checksum="E6EFAD32D2ECB081" modified="2016-04-13" version="1">MVIAHLIRDRDPRARNKSNTNQSNTSARLGFKIFLASIPLFKLTAAFYVDFIADSMDENVRPHNSTAAHHWLLRITQNDEGGWRWCCTDVETQRHVVCSIDAFLDCISSDTSQHPLLKILLLLSINSVHGTLGEVHVDEPGLRRANPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0L3</accession>
    <name>A0A103Y0L3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_021440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01003391">
        <property type="protein sequence ID" value="KVI00323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0L3"/>
    <dbReference type="STRING" id="59895.A0A103Y0L3"/>
    <dbReference type="Gramene" id="KVI00323">
        <property type="protein sequence ID" value="KVI00323"/>
        <property type="gene ID" value="Ccrd_021440"/>
    </dbReference>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI00323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="24777" checksum="FE1B0280F2571C16" modified="2016-04-13" version="1">MICNQQEEGVGGDSLILESSSKGGIVNSESCTVGGDRRRKMAVAGVVARNGLVSSRPVTFVTGNAKKLEEVKVILGQSIPFQSLKLDLPELQGDPEDIAKEKARLAANQVKGPVLVEDTCLCFNALKGLPGLNNMLMAYEDKSAYAMCIFSLAMGPNFEPITFVGKTQGKIVPARGPNDFGWDPIFEPDGYDQTYAEMAKEEKNKISHRSRALALVKSHFAEAGYVFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0N0</accession>
    <name>A0A103Y0N0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopterin transport-related protein BT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0N0"/>
    <dbReference type="STRING" id="59895.A0A103Y0N0"/>
    <dbReference type="Gramene" id="KVI00350">
        <property type="protein sequence ID" value="KVI00350"/>
        <property type="gene ID" value="Ccrd_021369"/>
    </dbReference>
    <dbReference type="OMA" id="QYSCSLP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF12">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 9, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="486" mass="53577" checksum="0D4142AA77C14440" modified="2016-04-13" version="1">MVDPVVFYLNNIKKKETEKQDRNLNGIQNLLNLCGFGYWVQGFRCFPWLALNFHMANNLNLNPSTLQLVQNFANLPMVAKPFYGILSDALFIGGSHRLPYISIGVLLQGISWGSMALSPMASQALPILMACVLLSNLGASITEVAKDALVAEYGQKNKINGLQSYAFMALAAGGVLGNFLGGFFLLRTHKPKSMFLIFASLMSFQLVLSLKTREESFGLPHSSNHHESIILNIKKQSSDLMIAIRDDGIFRSLSWVVASIAMVPILSGSIFCYQTQCLNLDPSIIGMSKVMGQLLLLTVAVVYDRCWKTISMRKLIGTVQILYASSLLLDLVLVKQINLKFGIPNHIFAVCISGVAEMIAQFKLLPFQVLFASLAPAGCEGSLMSFLASALCLSSICSGFLGVGMASFLGITSADYSNLPLGIMIQFLAALVPVFWIQNVPTSQPADEKEKKTGLSKRRRKTRRVGRVVFNMVFVYRRERESEAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1H6</accession>
    <name>A0A103Y1H6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phytosulfokine</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="9">Phytosulfokine-alpha</fullName>
                <shortName evidence="9">PSK-alpha</shortName>
                <shortName evidence="9">Phytosulfokine-a</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Phytosulfokine-beta</fullName>
                <shortName evidence="9">PSK-beta</shortName>
                <shortName evidence="9">Phytosulfokine-b</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">PSK-alpha is produced by endopeptidase digestion. PSK-beta is produced from PSK-alpha by exopeptidase digestion.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Sulfation is important for activity and for the binding to a putative membrane receptor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phytosulfokine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003245">
        <property type="protein sequence ID" value="KVI00799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1H6"/>
    <dbReference type="Gramene" id="KVI00799">
        <property type="protein sequence ID" value="KVI00799"/>
        <property type="gene ID" value="Ccrd_020939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009438">
        <property type="entry name" value="Phytosulfokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33285">
        <property type="entry name" value="PHYTOSULFOKINES 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33285:SF55">
        <property type="entry name" value="PHYTOSULFOKINES 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06404">
        <property type="entry name" value="PSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0765">Sulfation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8528" checksum="93F779E194D9CAB2" modified="2016-04-13" version="1">MNKIIKFIHYDGTMLIDSGNIVDPPSVPFFNLHKEEEVSNAKVEEKCLTGEEECLMRRTLAAHLDYIYTNKTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2E3</accession>
    <name>A0A103Y2E3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heat shock factor (HSF)-type, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003122">
        <property type="protein sequence ID" value="KVI01264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2E3"/>
    <dbReference type="SMR" id="A0A103Y2E3"/>
    <dbReference type="STRING" id="59895.A0A103Y2E3"/>
    <dbReference type="Gramene" id="KVI01264">
        <property type="protein sequence ID" value="KVI01264"/>
        <property type="gene ID" value="Ccrd_020472"/>
    </dbReference>
    <dbReference type="OMA" id="NEQVGYF"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000037">
        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF375">
        <property type="entry name" value="WINGED HELIX-TURN-HELIX DNA-BINDING DOMAIN, HEAT SHOCK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="12">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="332" mass="37539" checksum="31C6DDD879E1BCF5" modified="2016-04-13" version="1">MESNEVIAPFVMKTYQMVNDSSLDNLIRWGTSNNSFIVVDSLDFSQRLLPAYFKHNNFSSFIRQLNTYGFRKVDPDRWEFANEWFLRGQVHLLKNIERKRQVNSSRGKYTANSRGDDEGEEEMVMEIARLKQEQKALEEELIGMNKRLEATERRPEQMMALLCKVAEDPEILPRMMLEKVQRSKRLVDKKRQRRLITPPPPFPSSSSSSFEISNSIKREEDECYQMAKGSIVLSPEGYCSNEPLWRSSPSPVTPSTTVWPWNKDTCGRLGVDDDGGGFSMELEPINGINRYAYNTGGGGGGGGNTLFFGDGSGDPDVRPPPPYPFSLLGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y421</accession>
    <name>A0A103Y421_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, B-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002662">
        <property type="protein sequence ID" value="KVI02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y421"/>
    <dbReference type="Gramene" id="KVI02136">
        <property type="protein sequence ID" value="KVI02136"/>
        <property type="gene ID" value="Ccrd_019578"/>
    </dbReference>
    <dbReference type="OMA" id="PEISWMV"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009640">
        <property type="term" value="P:photomorphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000589">
        <property type="entry name" value="B-box zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051979">
        <property type="entry name" value="B-box_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31832">
        <property type="entry name" value="B-BOX ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31832:SF68">
        <property type="entry name" value="B-BOX ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="301" mass="32749" checksum="2CF6B3485BFDE9E5" modified="2016-04-13" version="1">MKIQCNVCEAAEATVLCCADEAALCWTCDEKVHAANKLASKHQRVPLSTSNTQMPKCDICQEAVGYFFCLEDRALFCRKCDVAIHTVNSLVSSHQRFLLTGVKVGLEAADPGVSSSTGKSHSCDKIPEAEKLQSLQGRSVPMSATSQFNKVMPVQAAGTVDFLFPKMPFAGGSSAESIQQWQFDDFLGLSDFSQSYNYIDNGSSKADSGKFGESDGSPILRDMEVELDGEDCLGQVPDSSWAVPQISSPPTASGLCWPKDLPHHQHQIDSAAFVPDVCYLPVPNFYGSQQNTGTLKRRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y474</accession>
    <name>A0A103Y474_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y474"/>
    <dbReference type="STRING" id="59895.A0A103Y474"/>
    <dbReference type="Gramene" id="KVI02215">
        <property type="protein sequence ID" value="KVI02215"/>
        <property type="gene ID" value="Ccrd_019465"/>
    </dbReference>
    <dbReference type="OMA" id="PEPTFHD"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF6">
        <property type="entry name" value="OS06G0683400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13195" checksum="CE82D0B840E8E254" modified="2016-04-13" version="1">MAESKNQSEFQDFLPLMAEKLGGDGLIGELCNGFRLLMDAEKGVITFDSLKNNSSVLGLQDLSDEDLLSMLREGDFDGDGALNQMEFCVLMFRLSPDLMDQSEVLLEEALELELNNSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4M7</accession>
    <name>A0A103Y4M7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4M7"/>
    <dbReference type="Gramene" id="KVI02450">
        <property type="protein sequence ID" value="KVI02450"/>
        <property type="gene ID" value="Ccrd_019242"/>
    </dbReference>
    <dbReference type="OMA" id="CHYNGAR"/>
    <dbReference type="OrthoDB" id="1302889at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040389">
        <property type="entry name" value="SMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142:SF48">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11783" checksum="B0E32D93F4211F28" modified="2016-04-13" version="1">MGFSKKHQVDGESLEGKKWVIAGIAMRAPLRSIVTKKVKEDDENSNSNSGDTTPTSKDSMIPEMLPCPPPPRKRRPVTTCYSGNREFFTSPDLDSLFKLLSNAGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5V8</accession>
    <name>A0A103Y5V8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002582">
        <property type="protein sequence ID" value="KVI03054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5V8"/>
    <dbReference type="STRING" id="59895.A0A103Y5V8"/>
    <dbReference type="Gramene" id="KVI03054">
        <property type="protein sequence ID" value="KVI03054"/>
        <property type="gene ID" value="Ccrd_018658"/>
    </dbReference>
    <dbReference type="OMA" id="FINDMDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF397">
        <property type="entry name" value="OS11G0242500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="146"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="674" mass="74744" checksum="55D759725B047B37" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6G3</accession>
    <name>A0A103Y6G3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002355">
        <property type="protein sequence ID" value="KVI03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6G3"/>
    <dbReference type="STRING" id="59895.A0A103Y6G3"/>
    <dbReference type="Gramene" id="KVI03401">
        <property type="protein sequence ID" value="KVI03401"/>
        <property type="gene ID" value="Ccrd_018300"/>
    </dbReference>
    <dbReference type="OMA" id="ESAFEWI"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44375">
        <property type="entry name" value="BETA-KETOACYL-ACP REDUCTASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44375:SF15">
        <property type="entry name" value="GLUCOSE_RIBITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="292" mass="31865" checksum="3ED85FD41BD3D6FD" modified="2016-04-13" version="1">MTMSTQETRIELEPWRDLRGTIVMVTGASSGIGWEFCIDLAKAGCKIIAAARRTERLRILCDKINKLDVSDGRVNQSQAKNNDVIAVAVELDVSADGPTIEASVRNAWEAFGRIDALINNAGFRGPIRGSLDLSEEDWDRTFSTNIRGSWLVSKYVCLQMLALNQGGSIINISSTAGVGRVFPPAVAYASSKSALDTMTKVMAMELGKHKIRVNSIAPGIFQSEITNELLEKKWFEKVVSRTVPLRDLGTTDPAMTSLVKYLIHDSSNYLTGNVFIVDAGYTLAGVPLFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6W9</accession>
    <name>A0A103Y6W9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002337">
        <property type="protein sequence ID" value="KVI03619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6W9"/>
    <dbReference type="STRING" id="59895.A0A103Y6W9"/>
    <dbReference type="Gramene" id="KVI03619">
        <property type="protein sequence ID" value="KVI03619"/>
        <property type="gene ID" value="Ccrd_018076"/>
    </dbReference>
    <dbReference type="OMA" id="ARYLWDD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF282">
        <property type="entry name" value="XYLOGLUCAN GALACTOSYLTRANSFERASE GT11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="8">
        <location>
            <begin position="162"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="600" mass="70317" checksum="AC561295EC6203A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6X9</accession>
    <name>A0A103Y6X9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTI65/LTI78 PGEED repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002336">
        <property type="protein sequence ID" value="KVI03642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6X9"/>
    <dbReference type="STRING" id="59895.A0A103Y6X9"/>
    <dbReference type="Gramene" id="KVI03642">
        <property type="protein sequence ID" value="KVI03642"/>
        <property type="gene ID" value="Ccrd_018073"/>
    </dbReference>
    <dbReference type="OMA" id="TEPNDKK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057059">
        <property type="entry name" value="LTI65/LTI78_PGEED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037491">
        <property type="entry name" value="LTI78/LTI65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33836">
        <property type="entry name" value="LOW-TEMPERATURE-INDUCED 65 KDA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33836:SF7">
        <property type="entry name" value="LOW-TEMPERATURE-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23399">
        <property type="entry name" value="LTI65_PGEED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTI65/LTI78 PGEED repeat" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="33934" checksum="837A302CF0BBED9E" modified="2016-04-13" version="1" fragment="single">EVSSRSSNSSPILQKNHDHDDHGNHHIKKSVFMRVKEKARKLKKSISGRKRRDENESRSPYATPPGMYEPTVEPEIDKHASKDNPRETNKGSSEKHKNTSNVDRGSTDSIDSKLSGLTVSGDRNANKPEPKENTTSSLQPQDKGVSVKEYLMHKLEPGEDERALSQAITQTISPRRDKMKEAMNTLLGTEEPSQSTSNKTSNSELDGSNLKQNAGDGSSIESSNVKTGSLADPPKPSNSVESNISNASNTNTCSTSTSASGQNQNQTGGSNLKPNSSSNPNDSNPSASSSSPNGQVDTNAKATEASTSTSSHEGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7H3</accession>
    <name>A0A103Y7H3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KOW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002321">
        <property type="protein sequence ID" value="KVI03914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7H3"/>
    <dbReference type="STRING" id="59895.A0A103Y7H3"/>
    <dbReference type="Gramene" id="KVI03914">
        <property type="protein sequence ID" value="KVI03914"/>
        <property type="gene ID" value="Ccrd_017789"/>
    </dbReference>
    <dbReference type="OMA" id="MASKPIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_uL24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI03914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="19203" checksum="53A94595EDA1FB58" modified="2016-04-13" version="1" fragment="single">TKSLCPIPSSPKSLIDDQPLTAHSDAVATTWDSRFPASDWHIMGWKAAQKLIHHWKILRGDNVMIIRGKDKGATGTIKRVIRSQNRVIVEGKNLVKKHIKQGQGHEGGIFTVEAPLHVSNVQIVDPVTRYVGTRYQEDGTKVRVSRAGPKDTPIELVHEKTYDAKTGKGMPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y812</accession>
    <name>A0A103Y812_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002294">
        <property type="protein sequence ID" value="KVI04226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y812"/>
    <dbReference type="Gramene" id="KVI04226">
        <property type="protein sequence ID" value="KVI04226"/>
        <property type="gene ID" value="Ccrd_017475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="19508" checksum="D2F0F7CFDC1C0B4F" modified="2016-04-13" version="1">MYSHVQSEGREPTAMEMFAMTHKTKGSDSGHFVTPRDEKYVADYLQEMNEKYRPDTSTIHTPIHLKILKYGSIVREEGKGVGCLELEKLKKMEEEPAVERERKMPERQWPLLSNCPATLMASACYAKLSHQKWKRSCVSHALLLGTGEVELLNHSTGSLTSVLTVLPSTSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8T8</accession>
    <name>A0A103Y8T8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001957">
        <property type="protein sequence ID" value="KVI04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8T8"/>
    <dbReference type="STRING" id="59895.A0A103Y8T8"/>
    <dbReference type="Gramene" id="KVI04628">
        <property type="protein sequence ID" value="KVI04628"/>
        <property type="gene ID" value="Ccrd_017057"/>
    </dbReference>
    <dbReference type="OMA" id="PLENRNM"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024593">
        <property type="entry name" value="DUF3444"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056988">
        <property type="entry name" value="Zn_ribbon_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137">
        <property type="entry name" value="BNAC03G44070D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137:SF32">
        <property type="entry name" value="DNAJ HEAT SHOCK AMINO-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11926">
        <property type="entry name" value="DUF3444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23551">
        <property type="entry name" value="Zn_ribbon_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="681" mass="76372" checksum="0430FF42E733344E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8W9</accession>
    <name>A0A103Y8W9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001938">
        <property type="protein sequence ID" value="KVI04691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8W9"/>
    <dbReference type="STRING" id="59895.A0A103Y8W9"/>
    <dbReference type="Gramene" id="KVI04691">
        <property type="protein sequence ID" value="KVI04691"/>
        <property type="gene ID" value="Ccrd_016989"/>
    </dbReference>
    <dbReference type="OMA" id="HGNKHIV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058778">
        <property type="entry name" value="HTH_FAR1-11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF291">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26175">
        <property type="entry name" value="HTH_FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="734" mass="83934" checksum="13B9A9E2241EB2EE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAS4</accession>
    <name>A0A103YAS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crontonase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAS4"/>
    <dbReference type="STRING" id="59895.A0A103YAS4"/>
    <dbReference type="Gramene" id="KVI05659">
        <property type="protein sequence ID" value="KVI05659"/>
        <property type="gene ID" value="Ccrd_016013"/>
    </dbReference>
    <dbReference type="OMA" id="CHEIRDC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113:SF1">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOYL-COA SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="260" mass="28793" checksum="EEBAF76CC6555ED1" modified="2016-04-13" version="1">MATGIQEKDLVTMRRRVAAVSNHLLPSPHSSISPIISSSNCSASMNDSYHRIHGEVPNHLPVWKIACDESGKDFTDIIYEKAEGEAIAKGTKAFCSGGDQALRSDDGYADFENFGRLNVLDLQVQIRRLPKPVIAMVAGYAVGGGHVLHMVGSFDAGYGSSIMSRLVGPKKAREMWFLARFYSAQEAERMGLINTVVPVKKLEEETVKWCREIIRNSPTAIREIGGNATLIFYGTEEGKEGKTAYMERRPPNFSKFPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBP9</accession>
    <name>A0A103YBP9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeodomain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001847">
        <property type="protein sequence ID" value="KVI06146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBP9"/>
    <dbReference type="STRING" id="59895.A0A103YBP9"/>
    <dbReference type="Gramene" id="KVI06146">
        <property type="protein sequence ID" value="KVI06146"/>
        <property type="gene ID" value="Ccrd_015496"/>
    </dbReference>
    <dbReference type="OMA" id="ENKSQHV"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF140">
        <property type="entry name" value="SWI_SNF COMPLEX SUBUNIT SWI3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72329" checksum="BA0ACF270FD1F515" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDP0</accession>
    <name>A0A103YDP0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001515">
        <property type="protein sequence ID" value="KVI07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDP0"/>
    <dbReference type="STRING" id="59895.A0A103YDP0"/>
    <dbReference type="Gramene" id="KVI07176">
        <property type="protein sequence ID" value="KVI07176"/>
        <property type="gene ID" value="Ccrd_014469"/>
    </dbReference>
    <dbReference type="OMA" id="RVWSMDY"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000853">
        <property type="entry name" value="WD repeat-containing protein RUP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044616">
        <property type="entry name" value="RUP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45389">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45389:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0287">Flowering</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="41343" checksum="4D53D3F0665BBB0A" modified="2016-04-13" version="1">MKNFSSESDPILPSQIPDQEERSSAKCEWDFRISAVISSFVTDGPISDTLGVIEVNSSGTLFATGGIARKIRVYSLSSLLSISPSGAEEPPLVDHATACLFCICTPAKLSSLKWKPGFAGRVMGSADYDGVVTEYDLETKMSIFERDEHNGRRVWSMDYSHWDPVVGASGSDDGTMQMWDPRHDGGKCVATVQLGSPVCCVEFCPFGGAMLAVGCADRKAYVYDVRKMDKAVAVFNGHERTVSYTRFLDDRTVMTSGTDGCLKMWDVENQRLIRTYRGHTNQRRFVGLSIWRNEGLIGCGSESNEMFVYDKRWGEPIWVHGFEPEGGTRRSEYGFVSSICWSQQGEDECTLVGGGSDGVVKTFSGKRKPLINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEV1</accession>
    <name>A0A103YEV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001487">
        <property type="protein sequence ID" value="KVI07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YEV1"/>
    <dbReference type="Gramene" id="KVI07796">
        <property type="protein sequence ID" value="KVI07796"/>
        <property type="gene ID" value="Ccrd_013843"/>
    </dbReference>
    <dbReference type="OMA" id="PCAYEIL"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052276">
        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF27">
        <property type="entry name" value="DNAJ DOMAIN, CHAPERONE J-DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17329" checksum="BA64415DBAEC9786" modified="2016-04-13" version="1">MAISTSSSFFTSPNFIFNSHPSSQSPSTSLRFGRAPISASYATAERTTTATEPIRSFRNPNPSSLYEXLGIRIGADVREVKAAYRRLARVLHPDVGSCDSSADEFMKVHSAYTTLTDPAKRADYDRSLVQRRAGVPSPMRSAGSYRSQRWETDQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGH5</accession>
    <name>A0A103YGH5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001100">
        <property type="protein sequence ID" value="KVI08633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGH5"/>
    <dbReference type="STRING" id="59895.A0A103YGH5"/>
    <dbReference type="Gramene" id="KVI08633">
        <property type="protein sequence ID" value="KVI08633"/>
        <property type="gene ID" value="Ccrd_012993"/>
    </dbReference>
    <dbReference type="OMA" id="KPDCAMC"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000004">
        <property type="entry name" value="probable cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000100">
        <property type="entry name" value="Putative cinnamyl alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="38721" checksum="F028CF9122BC274A" modified="2016-04-13" version="1">MVKSPEAEHPINAYGYAARDTSGTLSPLTFSRRATGDKDVRFKVLYCGICHSDLHFVKNEWGMTVYPVVPGHEIVGTVTEVGSKVEKFKVGDKVGVGCLVGSCSSCESCANDLENYCRKQILTYGSPCFDGTRTYGGYSDHMVADEHFVLRWPENLPLDTGAPLLCAGITTYSPLRYFGLDKPGVKVGVVGLGGLGHVAVKMAKAFGAEVTVFSTTPNKKQEALEGLKADHFIVSQDPEQMQSAASTLDGIIDTVSATHPIAPLLSVLKPHGKLVLVGIPEKPLELAAFSLIMGRKIVTGSAIGGLKETQEMLDFAAKHGVTADIEVIPIDYVNTAMDRILKSDVRYRFVIDVANSLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGJ2</accession>
    <name>A0A103YGJ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Late embryogenesis abundant protein, LEA-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001098">
        <property type="protein sequence ID" value="KVI08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGJ2"/>
    <dbReference type="STRING" id="59895.A0A103YGJ2"/>
    <dbReference type="Gramene" id="KVI08694">
        <property type="protein sequence ID" value="KVI08694"/>
        <property type="gene ID" value="Ccrd_012935"/>
    </dbReference>
    <dbReference type="OMA" id="WSCCLFF"/>
    <dbReference type="OrthoDB" id="1917746at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF72">
        <property type="entry name" value="NDR1_HIN1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="7">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="255" mass="28417" checksum="683BE13B77EC1836" modified="2016-04-13" version="1">MADHQRIHPDPVQPMNDLESHQKPTAPLVPRGSSKSDNANVVEPFPPHHRTIPVQYSKPPKKRGCCCRFMCWTLSLLVLLVISLGILAAIVYFGFDPKQPRYSVDGMTVTRFSLDNDTTLYAQFNVNITARNPNTKIGIYYEGGSKLTVLYRGTNLCEGSLPKFYQGHKNTTVLDVALTGQTRAATGVMNSLLAQQQTGTVPLVIRARVPVRIKLGKLKLPKWKPVVRCRLNVNGLSADNVIRIRDSSCSFKFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH06</accession>
    <name>A0A103YH06_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPsynthase alpha/beta subunit barrel-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH06"/>
    <dbReference type="STRING" id="59895.A0A103YH06"/>
    <dbReference type="Gramene" id="KVI08920">
        <property type="protein sequence ID" value="KVI08920"/>
        <property type="gene ID" value="Ccrd_012692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="8">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17089" checksum="349349B2544F82E3" modified="2016-04-13" version="1" fragment="single">MVNDPVLRTHKPLSVELGPGILGNIFDGFQRPLKTIAKRSGDVYIPRGVSVPALDKDILWEFQPKKLGKGDLVTGGDLYATVFENSLVEHHIALPPDTMGNITYVAPPGQYSLKDAVLELEFQGVKKKFTMLQTWPVRTPRPVASKLAADTPLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHA8</accession>
    <name>A0A103YHA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001071">
        <property type="protein sequence ID" value="KVI09070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHA8"/>
    <dbReference type="STRING" id="59895.A0A103YHA8"/>
    <dbReference type="Gramene" id="KVI09070">
        <property type="protein sequence ID" value="KVI09070"/>
        <property type="gene ID" value="Ccrd_012551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1412">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 83A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="210" mass="23403" checksum="0D313BBCBBCBE8A2" modified="2016-04-13" version="1">MGWAIQVAEKMGIRRASFWPASALALASMLNFHKLIDDGIINHSGVPLNDNTTQPSPTMPPIKPANLSWGCIGDLATTRSKLPRLPQWRNGYYATQVITWRLQRVAIFRSCCQLTSNRLAEQAGHFWPEDSTCLSWLDQQPACSVIYIAFGSFTILDQAHFEELPSSSTASPPTTTTDRQKKISLKLTVTATDRQKKISLKLTVTTTRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHH6</accession>
    <name>A0A103YHH6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_012445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHH6"/>
    <dbReference type="STRING" id="59895.A0A103YHH6"/>
    <dbReference type="Gramene" id="KVI09192">
        <property type="protein sequence ID" value="KVI09192"/>
        <property type="gene ID" value="Ccrd_012445"/>
    </dbReference>
    <dbReference type="OMA" id="NESYDEM"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000719">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="905" mass="97719" checksum="F9F328D83F985933" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHN6</accession>
    <name>A0A103YHN6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHN6"/>
    <dbReference type="STRING" id="59895.A0A103YHN6"/>
    <dbReference type="Gramene" id="KVI09248">
        <property type="protein sequence ID" value="KVI09248"/>
        <property type="gene ID" value="Ccrd_012338"/>
    </dbReference>
    <dbReference type="OMA" id="PNAKPHA"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000020">
        <property type="entry name" value="serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000294">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="87"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="51163" checksum="472A46AA0BAA97CF" modified="2016-04-13" version="1">MEPPWIDDLADDLQSISFNSTTTTATDINRSTSSGSETTWTTATYSARHNLSLPHTNKRSAPSGDPCWDAIRQAGSESGANLSLTDLRFIHRLGAGDIGAVYLSEIKRPSCSSSPALFAAKVMSKRELASRNKEGRARAEKEILEMLDHPFLPTLYASLESPKWSCLLTEFCPGGDLHVLRQRQPCKRFPESAVRFYASEVVVALEYLHMLDIVYRDLKPENVLVRSDGHIMLTDFDLSLKCDLSASTPAQVFSDHNRPNLPSSTDHYAFDPPKVTSSSCILPNCIVPSVSCFNPKRRRKKKLGNHGGPQFVAEPVDVRSMSFVGTHEYLAPEIVSGEGHGSAVDWWTLGIFIFELFYGITPFRGMDNELTLANIVARALEFPKEPVIPVGAKDLISQLLVKDPVRRLGSTMGASAIKHHSFFQGVNWALLRCTTPPFVPPPFNNREVVSDDSCSDTPVEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIM2</accession>
    <name>A0A103YIM2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001042">
        <property type="protein sequence ID" value="KVI09816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIM2"/>
    <dbReference type="Gramene" id="KVI09816">
        <property type="protein sequence ID" value="KVI09816"/>
        <property type="gene ID" value="Ccrd_011795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="16524" checksum="8EE51B06DAE8D990" modified="2016-04-13" version="1" fragment="single">MLSVEMFVHSHSHVSILIIPVASFGLLMWLLLPSLDAGMKFRKRCVVEINNRNTRHPIYICQLVRIHLKYQIRRRLQQLKKARSVVVDLCLLILYKMRLESWVLYLDLRCWKTQRSPCKMGLWICCNHSIYITWKWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ86</accession>
    <name>A0A103YJ86_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_011581</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001031">
        <property type="protein sequence ID" value="KVI10027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YJ86"/>
    <dbReference type="Gramene" id="KVI10027">
        <property type="protein sequence ID" value="KVI10027"/>
        <property type="gene ID" value="Ccrd_011581"/>
    </dbReference>
    <dbReference type="OMA" id="VDNLEWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF98">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119781" evidence="14">
        <location>
            <begin position="26"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1892"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="15">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="16">
        <location>
            <begin position="374"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="16">
        <location>
            <begin position="1298"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI10027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1940" mass="213639" checksum="ADF56235D828647C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL28</accession>
    <name>A0A103YL28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_010589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000959">
        <property type="protein sequence ID" value="KVI11005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL28"/>
    <dbReference type="STRING" id="59895.A0A103YL28"/>
    <dbReference type="Gramene" id="KVI11005">
        <property type="protein sequence ID" value="KVI11005"/>
        <property type="gene ID" value="Ccrd_010589"/>
    </dbReference>
    <dbReference type="OMA" id="PHENEFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010200">
        <property type="term" value="P:response to chitin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374:SF413">
        <property type="entry name" value="ZINC FINGER C2H2-TYPE_INTEGRASE DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20564" checksum="240346C5756B1D97" modified="2016-04-13" version="1">MGMKMIGNANTENFVRGNASLIAEHLEENPDGATSRYHRVYKCKDCDKEYDSFQALGGHRASHRKLMKETGAHCSGLQFLEESGPKLHECRICGKGFAIGQALGGHMRKHREMKLDTGQKDSLHNNANAKIWNTTVVSCNPDSSSVTSVSNGKVVFKYDLNLLPHENEFINAYWGSIKKRRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL92</accession>
    <name>A0A103YL92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RanBP2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000918">
        <property type="protein sequence ID" value="KVI11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL92"/>
    <dbReference type="STRING" id="59895.A0A103YL92"/>
    <dbReference type="Gramene" id="KVI11095">
        <property type="protein sequence ID" value="KVI11095"/>
        <property type="gene ID" value="Ccrd_010500"/>
    </dbReference>
    <dbReference type="OMA" id="KMNERFK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000014">
        <property type="entry name" value="Putative zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF29">
        <property type="entry name" value="OS07G0404300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="769" mass="88441" checksum="01E94B64906629F1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMY0</accession>
    <name>A0A103YMY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000019">
        <property type="protein sequence ID" value="KVI12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMY0"/>
    <dbReference type="Gramene" id="KVI12042">
        <property type="protein sequence ID" value="KVI12042"/>
        <property type="gene ID" value="Ccrd_009543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="24" mass="2863" checksum="0AA5B9BB4CCD024D" modified="2016-04-13" version="1">MQSKTQRITRGLIFLPFVSKKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMY3</accession>
    <name>A0A103YMY3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_009509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000016">
        <property type="protein sequence ID" value="KVI12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMY3"/>
    <dbReference type="Gramene" id="KVI12080">
        <property type="protein sequence ID" value="KVI12080"/>
        <property type="gene ID" value="Ccrd_009509"/>
    </dbReference>
    <dbReference type="OMA" id="THINMAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000479">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000062">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000125">
        <property type="entry name" value="Protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF56">
        <property type="entry name" value="LOW QUALITY PROTEIN: PROTEIN STRUBBELIG-RECEPTOR FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="349"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="665" mass="74242" checksum="57F271E6B7DC8EBB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNW4</accession>
    <name>A0A103YNW4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_009048</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNW4"/>
    <dbReference type="STRING" id="59895.A0A103YNW4"/>
    <dbReference type="Gramene" id="KVI12503">
        <property type="protein sequence ID" value="KVI12503"/>
        <property type="gene ID" value="Ccrd_009048"/>
    </dbReference>
    <dbReference type="OMA" id="ACKIWIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48514" checksum="0E5AA1A727D58AA5" modified="2016-04-13" version="1">MESRCKFWMPKKKRFCAIPRLSNSEFCGNHSKRSDDTWVPCSIDPSHSVLESNLQTHLKRCPLLKHKNSLALQPFYKKGINGGHDHHEPDVTSESKRMAVHSMTAPQFIKLIAKIKSVHASICNHIHDSFNLPEACKIWINRSIDWKIPFQEKHAIQQASILGNLEKLGAFKSSTTGLSEEELYCNNSSADPSDSPAVVEFGAGRGYLTQMLADCYGVSKVFLIERKSYKLKVSGADRSLRQKESLMLERLRIDIEDLNLNAIGSLQGLPFLAIGKHLCGPATDMTLRCCVGEHGRESKGVAATSYLRGVSIATCCHHLCQWKHYINRGFFSSLGMTKDEFHAITWFTSWAVDADHGSDDGVEKSESDEAVLGNEKVLGMLSAKERGVLGFMCKDIIDTGRLMWMRENGLESELVKYVPSNISPENHLLIGKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNZ2</accession>
    <name>A0A103YNZ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNZ2"/>
    <dbReference type="STRING" id="59895.A0A103YNZ2"/>
    <dbReference type="Gramene" id="KVI12505">
        <property type="protein sequence ID" value="KVI12505"/>
        <property type="gene ID" value="Ccrd_009096"/>
    </dbReference>
    <dbReference type="OMA" id="YHEKTDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010029">
        <property type="term" value="P:regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="39398" checksum="1953C48DA2D02CC4" modified="2016-04-13" version="1">MEATDMDIEVTQEQILDSCSSSKRFALKNSIQTNFGDDYVFQVVPKEDWTSMAVSLSSNTVKLYSPATGQYVGECCRGEHSDSINHILFSGNILHTCSSDGTLRAWDTRSYQQILFWDRRSKKQVACLEESHMDDVTQVHFIPDQQNKLLSASIDGLICTFDTSGEINDDDHLESVINVETSIGKVGLFGGSYDKLWCLTHIETLSIWDLTESRLEANFEDARPLASNSWALDQVDYLVDCHYSAADDRLWVIGGTNGGNLGYFPVAYGGGRRSILSPEAVLHDGHTGVVRSVCMRSGMNQTQGIFGWTGGEDGRLCCWLSDDSCDVNHSWISTSLVEKHPKNRRRKRHQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118HH80</accession>
    <name>A0A118HH80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008081">
        <property type="protein sequence ID" value="KVG49566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118HH80"/>
    <dbReference type="Gramene" id="KVG49566">
        <property type="protein sequence ID" value="KVG49566"/>
        <property type="gene ID" value="Ccrd_026389"/>
    </dbReference>
    <dbReference type="OMA" id="PSIVGRX"/>
    <dbReference type="OrthoDB" id="1629477at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVG49566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="9489" checksum="BDC6D38F236007C5" modified="2016-04-13" version="1">MADTEDIQPLVCDNGTGMVKARFAGDDAPRAVFPSIVGRXRHTSVMVGKGQKDAYVGDEAKSKRGILTLKYPIEHGIASNWDDMEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS66</accession>
    <name>A0A118JS66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S5 domain 2-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005864">
        <property type="protein sequence ID" value="KVH87761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS66"/>
    <dbReference type="STRING" id="59895.A0A118JS66"/>
    <dbReference type="Gramene" id="KVH87761">
        <property type="protein sequence ID" value="KVH87761"/>
        <property type="gene ID" value="Ccrd_024953"/>
    </dbReference>
    <dbReference type="OMA" id="WAPDQFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000034">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_uS9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="48139" checksum="24A3514DDE909189" modified="2016-04-13" version="1">MFWCRNREDERVCRELPDRNRSDEKSLRFVALNSSYQSHHKHHHPSLIQSPCSSSFFSSISRFFSTNNNNGSKSSDLWKISTENEESIESVFGEVTKSLEDFVGGGDAVKNHKEEESWFSSEWKEKGGGNDVEHDIFKVIESEGKRTEASRVNDKWGTGEGFTDWKFGVGDQKDGGEAEIFDIGDAGVSESAGLDGDVKLESQNKEEDRFLEIEEKALSEVLKGGPDHAFGDLIAASGITDEMLESLMALKDLDDVPGLPPLSEIEEMRYEKNTSKSTRADIERQKQEEITKSRVRQVDSQGRAYGTGKRKCSIARVWVEPGDGKFVINDKQFDVYFPMLDQRAALLRPLSETKTLGLLNVNCTVKGGGVSGQIGAIRLGMSRALQNWAPDQFRPPLKQAGFLTRDSRVVERKKPGKAKARKSFQWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSH6</accession>
    <name>A0A118JSH6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005348">
        <property type="protein sequence ID" value="KVH88691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSH6"/>
    <dbReference type="STRING" id="59895.A0A118JSH6"/>
    <dbReference type="Gramene" id="KVH88691">
        <property type="protein sequence ID" value="KVH88691"/>
        <property type="gene ID" value="Ccrd_026047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="10819" checksum="926BE0DBC6394DB2" modified="2016-04-13" version="1" fragment="single">YTHRYGALDEIEEFGEVKDISFVWIKQKKEKAHNFEHIDQLVSYDTEIERLIGVDINESSIWITLNEIIIDDPLARIITFRNPSASTNLFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTP9</accession>
    <name>A0A118JTP9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTP9"/>
    <dbReference type="STRING" id="59895.A0A118JTP9"/>
    <dbReference type="Gramene" id="KVH90191">
        <property type="protein sequence ID" value="KVH90191"/>
        <property type="gene ID" value="Ccrd_007788"/>
    </dbReference>
    <dbReference type="OMA" id="CKQTPHH"/>
    <dbReference type="OrthoDB" id="1918674at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15796">
        <property type="entry name" value="CIF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000009">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034087">
        <property type="entry name" value="C/VIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357:SF8">
        <property type="entry name" value="OS01G0111000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357">
        <property type="entry name" value="OS02G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159681" evidence="4">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="18293" checksum="6D9E9AE73D7644D9" modified="2016-04-13" version="1">MKFFCLFIFLSLQTPLMVIGDRRLIESTCKATPSYSLCLSTLLSNPKSSSGDVSDLGLIMVGATKVKATQAIQHIKTLYRVHPELRHSLNECSQVYMAVVKADVPSAVQALDGGQPKFAEDGMADTAVEAQACERSFSGRGQKSPLTQMNKDIENVANVARAIIRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUH6</accession>
    <name>A0A118JUH6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004863">
        <property type="protein sequence ID" value="KVH92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUH6"/>
    <dbReference type="STRING" id="59895.A0A118JUH6"/>
    <dbReference type="Gramene" id="KVH92066">
        <property type="protein sequence ID" value="KVH92066"/>
        <property type="gene ID" value="Ccrd_005910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="15115" checksum="2FE960EDA204064E" modified="2016-04-13" version="1">MKLLDVLSKFAEQSDRRIIVERLHPLEFNQRLHEYRSLIARCRNCGSGDNKDQLLICDKCGQGYHMSCLFPILDRVPVGPWYCRICYILSRRPKSTQRNSFNSFSPYVDLYNRRRDHFIFFSNLGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUQ8</accession>
    <name>A0A118JUQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rapid ALkalinization Factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant rapid alkalinization factor (RALF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUQ8"/>
    <dbReference type="Gramene" id="KVH91572">
        <property type="protein sequence ID" value="KVH91572"/>
        <property type="gene ID" value="Ccrd_006394"/>
    </dbReference>
    <dbReference type="OMA" id="ILAVHNW"/>
    <dbReference type="OrthoDB" id="1613518at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008801">
        <property type="entry name" value="RALF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136:SF107">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05498">
        <property type="entry name" value="RALF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159719" evidence="7">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="14320" checksum="439A21E19518BB55" modified="2016-04-13" version="1">MSKSAGLLVICAVILVAHMIALSFPAVDAASSGGDHHLGWIPTTTSTVGSACRGSMAECLAEGGDLDIDDMEFAMDSESHRRILANNRRYISYGALSRNNVPCSRRGASYYNCRSGGQANPYTRGCSAITRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUS0</accession>
    <name>A0A118JUS0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004897">
        <property type="protein sequence ID" value="KVH91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUS0"/>
    <dbReference type="STRING" id="59895.A0A118JUS0"/>
    <dbReference type="Gramene" id="KVH91942">
        <property type="protein sequence ID" value="KVH91942"/>
        <property type="gene ID" value="Ccrd_006033"/>
    </dbReference>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055122">
        <property type="term" value="P:response to very low light intensity stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042162">
        <property type="entry name" value="AtJ13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44914">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44914:SF1">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="504" mass="55584" checksum="7487374C0A04154C" modified="2016-04-13" version="1">MKKEEDGTSNRELYALLHVSPEASDEEIRKAYPTENFQRICQAYEILSDETKRQIYDIYGMEGLTSGLELGPKLNKAEEVKEELERLRRRREEEKTSAQFQPSGVILAQLSVPSFLAGHGIMRAMSMNSEIQSQISKNNVVAVGGTLAVKGNNGDAAANAVFRHQLSSVSSIEIMASAGLHGLIGLQTTRQLSRHASATMGLAISLRDGSINLSNSWNRQLSTTSNGSIELILGSDSSVAVGWRKKEQKMAAAGEIRIGTSAIGAVARYTRRFSSKSHGRISGKLGSGALELEIGGGRKISNFSTVRMLYTIGIQGIYWKLELHRGAQKLVVPIFLTRHFNLGFATGAFLIPTSLYLMLKSLVFKPYYRKREKEQALENMEQTRAQVQEAKAAAEKAQQLLQNVANRKRNKQSEMGGLVIIEAVYGSPNALKSINNPEEKKDELASQIMDVTLPLNFLVTDSGQLKLHEGVKKSGIMGFCDPCPDETKKLYVKYTYGGNRYETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV28</accession>
    <name>A0A118JV28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004814">
        <property type="protein sequence ID" value="KVH92531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV28"/>
    <dbReference type="STRING" id="59895.A0A118JV28"/>
    <dbReference type="Gramene" id="KVH92531">
        <property type="protein sequence ID" value="KVH92531"/>
        <property type="gene ID" value="Ccrd_005431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF1">
        <property type="entry name" value="INSERTASE, PUTATIVE (DUF1685)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="242" mass="26271" checksum="B12F689183CB87E0" modified="2016-04-13" version="1">MVMAAVGSEMKYKGEGEGVYEDETGIGATMEAREPAGDEAPIPGPNWALQPVPGRSPALTGLGMPPPHAAAPSPSMPPFSSPLYKQKSWSPDLHRDEEWMRRKGKHLHRRRRKSKSVTDEDINELKACIELGFGFDRSPELDDRLSTTLPALGFYYAVNKQYHDTISKSSSMSSSSSSSISYSSAVSEPDLSSPWGSPHTIINRGDNPHTVKTRLRQWAQVVACSVRLSTSSTSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV87</accession>
    <name>A0A118JV87_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH-quinone oxidoreductase, chain M/4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_004294</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004647">
        <property type="protein sequence ID" value="KVH93654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JV87"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF21">
        <property type="entry name" value="NAD(P)H-QUINONE OXIDOREDUCTASE CHAIN 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="13">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="14">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH93654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="348" mass="38722" checksum="32E34C9DE0F49F2C" modified="2016-04-13" version="1">MYSGQIGSFSSPDLLLFFIMWELELIPKRLYSATKFILYTAGGSIFLLMGVLGVGLYGSNKPTLNFETSVNQSYPVALEIILYIAFFIAFAVKSPILPLHTWLPDTHGEAHYSTCMLLVGILLKMGAYGLIRINMELLPHVHSIFSPWLMIVGTIQIIYAASTSPGQRNFKKKIAYSSVSHMGFILIGISSITDTGLNGAILQIISHGFIDVVLFFLAGTSYDRIRLVYLDEMGXVAIPMPKIFTMFSSFSMAFLALPGISGFVAEVIVFLGIITSQKYLLMPKIAITFVMAIGMILTPIYSLSMSRQMFYGYKLFNTPNSSVFXSGPRELFVSISILLLKEYLRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVB9</accession>
    <name>A0A118JVB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004595">
        <property type="protein sequence ID" value="KVH93847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVB9"/>
    <dbReference type="Gramene" id="KVH93847">
        <property type="protein sequence ID" value="KVH93847"/>
        <property type="gene ID" value="Ccrd_004105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="14034" checksum="85C56A7E8E95A3F3" modified="2016-04-13" version="1">MKMRHRRQQLLGGEGVGEDEREAGRGTCGSLESGASLFSREEEEEEEEEEEEEEEEEEEEEEEEEEEEEEQGEGIHRFFGQFFLGGENFSRRWREETRLYLGMERRDAMVAMEAMEAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVV1</accession>
    <name>A0A118JVV1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="2">HIB-CoA hydrolase</shortName>
            <shortName evidence="2">HIBYL-CoA-H</shortName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004620">
        <property type="protein sequence ID" value="KVH93701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVV1"/>
    <dbReference type="STRING" id="59895.A0A118JVV1"/>
    <dbReference type="Gramene" id="KVH93701">
        <property type="protein sequence ID" value="KVH93701"/>
        <property type="gene ID" value="Ccrd_004246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF6">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="240" mass="27126" checksum="42063A88DB1BCD18" modified="2016-04-13" version="1">MAASIHREADQVIFEEVVGGRKVILNRQKKLNTLNYEMLSKMTQKLKAYENDPTIKIVILKAIGKVFCVGGDLTSAFQFVAFGHWTFGTNYYRKEFCLDYILATYKKPLVAILDGSVMGGGVASMALVINKFAEEVDLKPGNAYSRLDMINQCFSGESCEEILSSLIREGRSKTLEQCLQTEYVAICHVLRRTVSNDFYEDVSDEMVAKCLSRSFTEDDDWLPLRLPSRLKKVEAMTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW31</accession>
    <name>A0A118JW31_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYB transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_003958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds preferentially double-stranded telomeric repeats.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004579">
        <property type="protein sequence ID" value="KVH93984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW31"/>
    <dbReference type="Gramene" id="KVH93984">
        <property type="protein sequence ID" value="KVH93984"/>
        <property type="gene ID" value="Ccrd_003958"/>
    </dbReference>
    <dbReference type="OMA" id="QCCRDEV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000168">
        <property type="entry name" value="Telomere repeat-binding factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.220:FF:000002">
        <property type="entry name" value="Telomere repeat-binding factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044597">
        <property type="entry name" value="SMH1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267">
        <property type="entry name" value="SINGLE MYB HISTONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267:SF15">
        <property type="entry name" value="WINGED HELIX-TURN-HELIX TRANSCRIPTION REPRESSOR DNA-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="14">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH93984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="259" mass="28544" checksum="5AE433063980C18B" modified="2016-04-13" version="1">MGNPKQKWTSEEEEALRAGVAKHGTGKWKNIQKDPEFNHFLYSRSNIDLKDKWRNMSVSANGQGPREKSRTPKPKVNTDSPATPLPIAQAPGSSALVVVDPASTDVLMDDSSQCVLDGKTTSKYNAMIYEALSTLKDPNGSDISAIVSFIEKRHEVPQNFRRLLGSRLRRLVAQEKLEKGPIPKPKEIRPRLSQVNSYLGGTLEEAAVAAAYKVAEAENKSFVAAEAVKEAERVAKMAEEADAFLQLAKEIYDKFGGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX45</accession>
    <name>A0A118JX45_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003990">
        <property type="protein sequence ID" value="KVH96952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX45"/>
    <dbReference type="Gramene" id="KVH96952">
        <property type="protein sequence ID" value="KVH96952"/>
        <property type="gene ID" value="Ccrd_000955"/>
    </dbReference>
    <dbReference type="OMA" id="RFVQDDQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054296">
        <property type="entry name" value="DUF7032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043:SF5">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23005">
        <property type="entry name" value="DUF7032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7032" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="532" mass="58430" checksum="179D1806C7E0FE55" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY33</accession>
    <name>A0A118JY33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004307">
        <property type="protein sequence ID" value="KVH96445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY33"/>
    <dbReference type="STRING" id="59895.A0A118JY33"/>
    <dbReference type="Gramene" id="KVH96445">
        <property type="protein sequence ID" value="KVH96445"/>
        <property type="gene ID" value="Ccrd_001469"/>
    </dbReference>
    <dbReference type="OMA" id="HEHCHPS"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000223">
        <property type="entry name" value="probable receptor-like protein kinase At1g80640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000342">
        <property type="entry name" value="Protein kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF27">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159798" evidence="9">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="157"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="452" mass="49583" checksum="BFCB8B5A490022FE" modified="2016-04-13" version="1">MKFFLTFSLVLILDFGITSIDARPTSLLPVSAIFVPESAPAAAPIPSIPSSMADFSSGTQVNIPEHQRNSSRKLLIGLITSASVMGILILSIICLWICHRKKIGKSGKNNTKRLDSLRGLPLSSFISRSSGPIKTINEKGSVVVMDYSLLESSTNNFGESEILGEGGFGCVYRARLDDNLYVAVKRLDGGSHDAIKEFQTEVDLLTKIQHPNIITLLGYCVHDETKLLVYELMHNGSLETQLHGPSSGSNLTWHCRMKIALDTARGLEYLHENCKPSVIHRDLKSSNILLDSSFNAKLSDFGLAVMDGAQNKNNIKLSGTLGYVAPEYLLDGKLTDKSDVYAFGVVLLELLLGRRPVEKLAESQCQSIVTWAMPQLTDRSKLPNIVDPVIRYTMDLKHLYQVAAVAVLCVQPEPSYRPLITDVLHSLTPLVPVELGGTLRVAQTWPSKTTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY40</accession>
    <name>A0A118JY40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY40"/>
    <dbReference type="STRING" id="59895.A0A118JY40"/>
    <dbReference type="Gramene" id="KVH97959">
        <property type="protein sequence ID" value="KVH97959"/>
        <property type="gene ID" value="Ccrd_023827"/>
    </dbReference>
    <dbReference type="OMA" id="NEQSEKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000335">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH97959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="264" mass="28899" checksum="9E9A57EB602F2FD9" modified="2016-04-13" version="1">MAIPHPYDPVYYNLPSIPPLEYAGYDDPNAINTLFVSGLPDDIKAREIHNLFRRRPGFDYCQLKYTGRGNQVVAFATFVNHPSAIACLHALNGVKFDPQTGSTLHIELARSNSRRKRKPGHGAYVVIDKRSTAAKDGQDSSDDGDSETEEPSEANKHASTNKDNKSDEETAVDPDNTGAAENEHTENAVDGACSTLFIANLGPNCTEDELKPVLSRGGMPVAFADYEEVEQATEVMNALQGSTLPSSDRGGMHIEYARSKMRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K023</accession>
    <name>A0A118K023_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003278">
        <property type="protein sequence ID" value="KVI00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K023"/>
    <dbReference type="Gramene" id="KVI00765">
        <property type="protein sequence ID" value="KVI00765"/>
        <property type="gene ID" value="Ccrd_020982"/>
    </dbReference>
    <dbReference type="OMA" id="THAQECI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13483" checksum="10BA22D53732584F" modified="2016-04-13" version="1">MAMETSMVFNKYDHHDVNTSSKIPIKGGWKSAIYIIFVEFGERFAYYGVSGNLIMYLTLVLKEPLATAAKNVNIWHGVAAIFPLVGGFMADSYLGRFKTIIFSSFTYLLVGFLFNFVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K039</accession>
    <name>A0A118K039_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003406">
        <property type="protein sequence ID" value="KVH99910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K039"/>
    <dbReference type="STRING" id="59895.A0A118K039"/>
    <dbReference type="Gramene" id="KVH99910">
        <property type="protein sequence ID" value="KVH99910"/>
        <property type="gene ID" value="Ccrd_021849"/>
    </dbReference>
    <dbReference type="OMA" id="WIGYERE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032795">
        <property type="entry name" value="DUF3741-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P DOWN SYNDROME CRITICAL REGION PROTEIN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726:SF57">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14383">
        <property type="entry name" value="VARLMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="734"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="99542" checksum="8EDA533125D8F9A0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0G2</accession>
    <name>A0A118K0G2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003130">
        <property type="protein sequence ID" value="KVI01123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0G2"/>
    <dbReference type="STRING" id="59895.A0A118K0G2"/>
    <dbReference type="Gramene" id="KVI01123">
        <property type="protein sequence ID" value="KVI01123"/>
        <property type="gene ID" value="Ccrd_020617"/>
    </dbReference>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="27994" checksum="B16022645FFFE508" modified="2016-04-13" version="1">MAEELVLDTAIRDWVLIPLSVVMVLIGVLRYFVSKLMRTSQLPDAKIIKEGQVIIRARNLRAAANFIPAKAFRARKLYYTNEDNGLLHVPKGQAQNPQAQMFSDPNMAMDMMKKNLSMIIPQTLTFAWVNFFFSGFVAAKIPFPLTQRFRSMLQNGIDLSTVDVSYVSSRSWYFLNLFGLRGLFSLILGEENATDDTQRMMQMSGFGFDPSKSLGAEKDGLDIVQHEWVLPKFEQRAEAVLRKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0T7</accession>
    <name>A0A118K0T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14, caspase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002681">
        <property type="protein sequence ID" value="KVI01832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0T7"/>
    <dbReference type="STRING" id="59895.A0A118K0T7"/>
    <dbReference type="Gramene" id="KVI01832">
        <property type="protein sequence ID" value="KVI01832"/>
        <property type="gene ID" value="Ccrd_019888"/>
    </dbReference>
    <dbReference type="OMA" id="DANQQGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF2">
        <property type="entry name" value="METACASPASE-1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="40773" checksum="12F9329EC72F8E02" modified="2016-04-13" version="1">MSSLDNVAKCSDLSSVSPEDQPICCPDCRDVFWVDGETPVQSSRDRGKLVCDTKGLNIRFKKMWQRRQLPDPNYFSSYEKLAIEMIRNWEPTKGKRALLCGVTYNKQKYKLKGTNYDVNSMRELLISRFQFPSTSIRTLAGFRSIISIDIARELAETDSHLLPTKRNIQEALRWLVKDNQKGDSLVFYFSGHGLRQPDFFDDERDGFDETICPLDFKTAGMIIDNEINETIVRPLVKGVKLHAIIDACHSGTILDLPLVFNTKNPPSGVYKGTSGGHAISISACEDNQLAADTSAFSKQMEGAMTYTLRKAVEGNRRVTYASLLASMHKDILAAKATRFCLRRLCHRERQQVSLGFRLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K171</accession>
    <name>A0A118K171_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARID/BRIGHT DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds preferentially DNA with A/T-rich content.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K171"/>
    <dbReference type="STRING" id="59895.A0A118K171"/>
    <dbReference type="Gramene" id="KVI02388">
        <property type="protein sequence ID" value="KVI02388"/>
        <property type="gene ID" value="Ccrd_019347"/>
    </dbReference>
    <dbReference type="OMA" id="FTEHYIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16872">
        <property type="entry name" value="ARID_HMGB9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000022">
        <property type="entry name" value="High mobility group B protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045303">
        <property type="entry name" value="ARID_HMGB9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46691:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46691">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="31700" checksum="1DC75207912518A7" modified="2016-04-13" version="1">MSAPHLSYGPKTAVFTNGYGTPTTSYPSPEASYEEITQNPQFFLEKLQIFHSVFGTKFKIPIIGGKSLDLHRLFIEVTSRGGIEKIVSDRRWKEVMAVFKFGPTITNASFVLRKYYLSLLYHFEQVYYFRKKTPTIVPADATNRLSGGSGSVKNLFSGRRMVEVGGQVTGTIDKRFDHGYVVTVDMGSEKLSGFLYHLPSDSPAPSHGTHNMYQLALREPSPEPDTSGYDVFFTEHYIRFIRKRDQEARKDRSRQRLLTRIELVLGRLRAIFFFSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K442</accession>
    <name>A0A118K442_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001540">
        <property type="protein sequence ID" value="KVI06943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K442"/>
    <dbReference type="STRING" id="59895.A0A118K442"/>
    <dbReference type="Gramene" id="KVI06943">
        <property type="protein sequence ID" value="KVI06943"/>
        <property type="gene ID" value="Ccrd_014723"/>
    </dbReference>
    <dbReference type="OMA" id="PVYDTQC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="73"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI06943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="38177" checksum="CF6726F7228DFA0E" modified="2016-04-13" version="1">MELWGWRWTMMFELVVIVTLVIGFGLVVAIAVETFRRRFNHAHLEAHPIFEDPNSFEQVQCPYINDPAEKYISLIIPAYNEEYRLPAALDEALNYLQQRSKKDESFSYEIIIIDDGSSDRTKRIAFDFVRKNKVDNVRVILQRKNQGKGEAIRKLLAYAKALQKQGMLHSRGELLLMLDADGATKVDDLEKLENQILAVAKTKGQVASDSSKGIADIPIVAFGSRAHLEKKALATRKWYRNFLMKGFHVIVLLAAGRGVRDTQLFTNIRLKRWCFDVELVYLCKYFHIPILEISVNWSEIPGSKVNPLSILNMLWELALMSLGYRTGIWNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6J6</accession>
    <name>A0A118K6J6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Citrate transporter-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_010803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000998">
        <property type="protein sequence ID" value="KVI10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K6J6"/>
    <dbReference type="Gramene" id="KVI10802">
        <property type="protein sequence ID" value="KVI10802"/>
        <property type="gene ID" value="Ccrd_010803"/>
    </dbReference>
    <dbReference type="OMA" id="WKLIAYA"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045016">
        <property type="entry name" value="NhaD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038006">
        <property type="entry name" value="NhaD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43269">
        <property type="entry name" value="SODIUM/PROTON ANTIPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43269:SF2">
        <property type="entry name" value="SODIUM_PROTON ANTIPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="13">
        <location>
            <begin position="198"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="577" mass="61520" checksum="E4C231C4D67FF41C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6V9</accession>
    <name>A0A118K6V9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH:ubiquinone/plastoquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_010283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000388">
        <property type="protein sequence ID" value="KVI11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K6V9"/>
    <dbReference type="Gramene" id="KVI11308">
        <property type="protein sequence ID" value="KVI11308"/>
        <property type="gene ID" value="Ccrd_010283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="14">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="28015" checksum="AD406C57DAD1662B" modified="2016-04-13" version="1">MKAEFVRILPHIFIINATFILLIHGVVFSTSKKFDYPPLVSNXGWLGLLSVARLGGQRALGCGGAIIAQFPNLMRHRVRTAGNRSXGGLRILLPPQGWLIVRSRLEDPWFWKAHESERYVXCATDTSTAGTISMCFDSSEQERFDASESIVLIPLPTRSMLFMISAYDSIAMYLAIEPQSLCFYVIAASKRKSEFSTEAGSKYLILGAFSSGILLFGMKMIHSPRRPSTRAVRVDSIANRRPSATTRSSAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RB74</accession>
    <name>A0A124RB74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_026278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007816">
        <property type="protein sequence ID" value="KVG66831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RB74"/>
    <dbReference type="STRING" id="59895.A0A124RB74"/>
    <dbReference type="Gramene" id="KVG66831">
        <property type="protein sequence ID" value="KVG66831"/>
        <property type="gene ID" value="Ccrd_026278"/>
    </dbReference>
    <dbReference type="OMA" id="TKEIANC"/>
    <dbReference type="OrthoDB" id="642974at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF260">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVG66831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="24160" checksum="47ABFE44D2E18C2F" modified="2016-04-13" version="1">MMHLKETELCLGLPGGGGHNQEEPLKITGKRGFSETTHLKLNFVQPNESSSSSSDVSKDTTTTLYVKSPPAKAQVVGWPPVRNHRKNVIGGKRKTEEARLVKVSMDGAPYLRKVDLKMYKSYQQLSDALANMFCSFTTGNDGRQGMMTELMKESRLMDLLNSSEYVPSYEDKDGDWMLVGDVPWQMFVDSCKRLRIMKGSDAIGLAPRAMEKCRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBU9</accession>
    <name>A0A124SBU9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004905">
        <property type="protein sequence ID" value="KVH91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBU9"/>
    <dbReference type="Gramene" id="KVH91780">
        <property type="protein sequence ID" value="KVH91780"/>
        <property type="gene ID" value="Ccrd_006190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16003" checksum="D29F79CE3322CE95" modified="2016-04-13" version="1">MESKNISSDVNDLRSPSNYNEFLLRHSLLFADGLKSLRTCQAYADHGGLIHQSLMMETPKYRKKYLLPEGCISEDVKAKQVKGRSSGLRNGYSGQASTELPSGLITFSFTKSASRKGVATIRGLEISFLVSTKREHKRYRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCP6</accession>
    <name>A0A124SCP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCP6"/>
    <dbReference type="STRING" id="59895.A0A124SCP6"/>
    <dbReference type="Gramene" id="KVH94450">
        <property type="protein sequence ID" value="KVH94450"/>
        <property type="gene ID" value="Ccrd_003487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046955">
        <property type="entry name" value="PHR1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR PHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499:SF6">
        <property type="entry name" value="PROTEIN PHR1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="105" mass="11860" checksum="83D6154C5656F0A2" modified="2016-04-13" version="1">MYSGIHSIPLEGTGIAHADLPRHLPTTNLVGDPCLVLTTDPKPRLRWTAELHERFVDAITQLGGSNSDGGRWKKRIEPMWKKTRTNNTHGQRHGNYDASIYKDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD69</accession>
    <name>A0A124SD69_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004365">
        <property type="protein sequence ID" value="KVH96012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD69"/>
    <dbReference type="STRING" id="59895.A0A124SD69"/>
    <dbReference type="Gramene" id="KVH96012">
        <property type="protein sequence ID" value="KVH96012"/>
        <property type="gene ID" value="Ccrd_001914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="19191" checksum="A89480098A1D2E84" modified="2016-04-13" version="1">MIKLNHRQQLDVPKGYLAVQKSRKDEERTDPLSIGAYGNEESNFNGEGNSTSYSSFVYGGSNFFVNGIETIVGLFINFFHTSCWLQSLVSNAKHLIKRQDVPKGYLAVYVGEIQRKRFVVPLSYLDQPGFQDLLRRSEEEFEFQHPMGGLTIPCNEEAFVQLTTQLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDQ1</accession>
    <name>A0A124SDQ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003823">
        <property type="protein sequence ID" value="KVH97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDQ1"/>
    <dbReference type="STRING" id="59895.A0A124SDQ1"/>
    <dbReference type="Gramene" id="KVH97645">
        <property type="protein sequence ID" value="KVH97645"/>
        <property type="gene ID" value="Ccrd_000237"/>
    </dbReference>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27326" checksum="8E555D53DB16664C" modified="2016-04-13" version="1">MGIVGTMTSDQLQFFNSQGYLVIESFSSSEEVEALRKRMDQLLDGFDCSSSASIFSTKNQQRTSDDYFYESADKISFFFEEYNLMLLFVALHDHDPIFKNVSCSDKMSGLLLSLGYKRPVIIQSMYIFKQPGIGGEVVPHQDNSFLYTDPPSCTGLWLALEDATIVNGCLWAIPGSHKDGLVRRFIRDDKGVHFDNPSPSYDQKDFVSIEVKAGSLVLIHGDLIHQRIRRNVDPEPLYGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE56</accession>
    <name>A0A124SE56_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE56"/>
    <dbReference type="STRING" id="59895.A0A124SE56"/>
    <dbReference type="Gramene" id="KVH99025">
        <property type="protein sequence ID" value="KVH99025"/>
        <property type="gene ID" value="Ccrd_022716"/>
    </dbReference>
    <dbReference type="OMA" id="RIHNMDG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14220" checksum="1F0BFC43AFF12F05" modified="2016-04-13" version="1">MAGEEAVIPVEAPAPALGEPMDIMTALQLVLRKSLAHGGLVRGLHEAAKVIEKHAALLCVLAEDCNQPDYQKLVKALCADHNVSLISVPAAKTLGEWAEGKARKVVGCSCLVVKDYGEETEGLHIIQEYVKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFS1</accession>
    <name>A0A124SFS1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002307">
        <property type="protein sequence ID" value="KVI04123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFS1"/>
    <dbReference type="STRING" id="59895.A0A124SFS1"/>
    <dbReference type="Gramene" id="KVI04123">
        <property type="protein sequence ID" value="KVI04123"/>
        <property type="gene ID" value="Ccrd_017572"/>
    </dbReference>
    <dbReference type="OMA" id="MTIFMPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15951" checksum="335C809A30C0D7C5" modified="2016-04-13" version="1">MAIPKEEEFGYNRPMGGLTIPCREDIFTDLVSRLGNTTDSALFGKMTIFMPRIIQAKQILRRSLSNGSSNTYMAIPKGYFAVYVGDQEKKRFVVPIALLGQPAFQELLCQAEEKFGYNHPMGGFTIPCSKDMFIDLASRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG34</accession>
    <name>A0A124SG34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG34"/>
    <dbReference type="Gramene" id="KVI05148">
        <property type="protein sequence ID" value="KVI05148"/>
        <property type="gene ID" value="Ccrd_016507"/>
    </dbReference>
    <dbReference type="OMA" id="CEQMKEY"/>
    <dbReference type="OrthoDB" id="192915at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176235" description="DUF3456 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="2">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="188" mass="21401" checksum="4FE321B6E8DEE190" modified="2016-04-13" version="1">MALTAALRRLIFVAAIFIALSIAHSIDDKCSACNAVAEELELGMMKEKPKNHLDMRHRLDSKGQRRGKVIDYRTSELRVVDLLDGLCDKMQDYTLQKMDSTEKVWIKVDSWDDITSNKQESRAYSKEISSYCGRLLEDTEDELAELIMKGSVKVGEVSKVLCHDLSKHCKQTSDYHQSSNNEEVNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGX5</accession>
    <name>A0A124SGX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001491">
        <property type="protein sequence ID" value="KVI07756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SGX5"/>
    <dbReference type="Gramene" id="KVI07756">
        <property type="protein sequence ID" value="KVI07756"/>
        <property type="gene ID" value="Ccrd_013883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36781">
        <property type="entry name" value="OS05G0114600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36781:SF1">
        <property type="entry name" value="OS05G0114600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12631" checksum="5AFF95E42ECC5E55" modified="2016-04-13" version="1">MAGNSIKSVAKAVGEYQYPWRDRLTKYKDELSKGVWGHWHLGAWKPLGVXRKEMRTKRKGHXCDRISAEKRAKTAELMRKMPQMLADYRKKWWEKKMNEEDAAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI00</accession>
    <name>A0A124SI00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000891">
        <property type="protein sequence ID" value="KVI11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI00"/>
    <dbReference type="STRING" id="59895.A0A124SI00"/>
    <dbReference type="Gramene" id="KVI11133">
        <property type="protein sequence ID" value="KVI11133"/>
        <property type="gene ID" value="Ccrd_010458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF39">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="40482" checksum="72AD15CF52B910E6" modified="2016-04-13" version="1">MQFRVGDTSGSDQFEYGRVRNVVRALGTQIESRETARRLDQTGDGEKLRKRVESSREEESERGKGVRCNTQQQVRQSHAEAIRKAKRFRAGSEGGFNHPTLSAIPDVFFVFGLQLCLGNFVRFGSVFFSRPEPAQPELYTLVGGESFAFKLLTTYTYSSSDLSSSESFMETTPSRELNKEEVVVNVLEPKKEPPRATWPPPMAIPFPPREAILTGIVGESGEIFRSPAALARLKVYEGVPTPYNRKKRMVIPDVLKVLRLTVRHKYCLLGQLSSEVGWNHYETIKSRRLDQNQRKDKKRKQEQTRRNSMRILQQLRETRTRINENDKTVKCRSDPFNCRERSETRPKKPTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI75</accession>
    <name>A0A124SI75_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA recombination and repair protein Rad51, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000039">
        <property type="protein sequence ID" value="KVI11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI75"/>
    <dbReference type="STRING" id="59895.A0A124SI75"/>
    <dbReference type="Gramene" id="KVI11807">
        <property type="protein sequence ID" value="KVI11807"/>
        <property type="gene ID" value="Ccrd_009777"/>
    </dbReference>
    <dbReference type="OMA" id="WANQVTV"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33679" checksum="9FAA555DBB21F379" modified="2016-04-13" version="1">MRPDSLLLRPANTQYCTLGCPILDAFLGGGIPCNSITELVSESGCGKTQLSLQLLFTAQLPLHLNGLSGSSLYLYSEFPFPNRRFNQLLESFRLSHPILFASSRDPRDYIFTRDCQTAQDLLDVLLLLESRLEKPKETRLDIKLIVIDSIAALFRSEFENNPRDLKRRSSLFFKISSLLKSHAKRFGIAIVLTNQVVDSIEDNEGSSGIRVGNLEWLYTSGRRVWPALGLSWANCVNSRLFLSRYEVTEGVENASPDADYIGFVNRRKTRELHVVFAPHLPYSTCEFVITREGVSGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D674</accession>
    <name>A0A103D674_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011451">
        <property type="protein sequence ID" value="KVD98532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D674"/>
    <dbReference type="STRING" id="59895.A0A103D674"/>
    <dbReference type="Gramene" id="KVD98532">
        <property type="protein sequence ID" value="KVD98532"/>
        <property type="gene ID" value="Ccrd_024110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007114155" evidence="2">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVD98532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12468" checksum="95374516146AC228" modified="2016-04-13" version="1" fragment="single">MEVSMATVMGVGLVLLLLILTLALLHACAFPKEMDGIPGSFGWPFLGESLSFISEFSSPAGIFSFMNKRQQRYGKVFKSYVLGRYMVFTTGMEASKMLLTGKDGMVSLNLFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103GEX3</accession>
    <name>A0A103GEX3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01010226">
        <property type="protein sequence ID" value="KVE70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103GEX3"/>
    <dbReference type="Gramene" id="KVE70390">
        <property type="protein sequence ID" value="KVE70390"/>
        <property type="gene ID" value="Ccrd_023916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVE70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13040" checksum="B945970549EA8A61" modified="2016-04-13" version="1">MSNVYGMMGRYQEVSDVRHNMRQQNVKKTPGCSWIEFGDGMHVFGTGDRTHPDEELIYSMLSSLYMSMYMYSDEVTIVGVLSGCNYGDLSRYNIVSMVKHCTCVIDMLGRAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103HS03</accession>
    <name>A0A103HS03_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009970">
        <property type="protein sequence ID" value="KVE95150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103HS03"/>
    <dbReference type="Gramene" id="KVE95150">
        <property type="protein sequence ID" value="KVE95150"/>
        <property type="gene ID" value="Ccrd_026883"/>
    </dbReference>
    <dbReference type="OMA" id="FYAMPAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000333">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000345">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF484">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVE95150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="420" mass="46980" checksum="5D72824457204BA8" modified="2016-04-13" version="1" fragment="single">MDLSMTQDLSTQPQEGDFGSPSELKDILQIDPQLIQKESDLCHRIRISLSNGTPKEAIVIYAQNRRNPLCILSVVPLVFKACASLSMINNGKANVVTWTVMVEGYASNGQMNAAKDIFEAMPQRNFFVYSSMISGYFKNGHVEEGKAIFDRIKVRNLVNWNSLISGYCHNGLCEEALDAFAKMQADGFEPDEVSFACALSACAQLGSLKTGITLHHMIIQRSIKLNQFILNGLVDMYAKCGDLTNARLIFEGMLERNDACWNAMISGFSIHGHCKEALEFFDRMVKSSVNPNEITFLSVLTACAHSGFIREGLETFSKMENYGLSPNIKHYGCLVDLLGRAGRLKDAYRIVIDMPMRPNDMIWMALLGACRVHADMDMANQVLERVRDQVSGDCSHYVLMSNMYAASERWEKAESVRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103L7K6</accession>
    <name>A0A103L7K6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009128">
        <property type="protein sequence ID" value="KVF70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103L7K6"/>
    <dbReference type="STRING" id="59895.A0A103L7K6"/>
    <dbReference type="Gramene" id="KVF70682">
        <property type="protein sequence ID" value="KVF70682"/>
        <property type="gene ID" value="Ccrd_026708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010190">
        <property type="term" value="P:cytochrome b6f complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044970">
        <property type="entry name" value="CCB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021325">
        <property type="entry name" value="CCB2/CCB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36403">
        <property type="entry name" value="PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36403:SF1">
        <property type="entry name" value="PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11152">
        <property type="entry name" value="CCB2_CCB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13240" checksum="AB277BC3905FC0A0" modified="2016-04-13" version="1">MMGFPRTEVLGLSLTAFSVVLPYIGQFFKGATRVLQANILEGVVQIFPMSPNISNTVKEDLAWGSYTLLRNTNSISVKKSERREKMVLGSGICAREVVMDARHHMLGRLSSILAKEVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RIV1</accession>
    <name>A0A103RIV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007792">
        <property type="protein sequence ID" value="KVG68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103RIV1"/>
    <dbReference type="STRING" id="59895.A0A103RIV1"/>
    <dbReference type="Gramene" id="KVG68573">
        <property type="protein sequence ID" value="KVG68573"/>
        <property type="gene ID" value="Ccrd_026275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF18">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-14R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malectin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="33759" checksum="D6FFF4CE02568C42" modified="2016-04-13" version="1">MPDQAFEGGDFLKTNETILDGGSLSSLYQSARFGNFCYSFEDLSSRDYFLDLHFAEIINTNGPEGMRVFDAFVQDEQVVSELDVYSYVGANRPLKLIDIRVTVGLDGMLVIKFKGVHGTPIIMKQEQTQLSCDVREYANLILDMDNMISAIQGQVAQCEDLKQKYNEELVKRRKLYNQIQEAKGKFSHSCRSLDKHEVSAGHVMVVDLSASRDGDLGILDKAKQDLKSKDEALKKVGRKSTELGSERLNARIRCRKVTEVENKLKERTQMFELKLSASEEKIKKLENGLERQDDHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RK52</accession>
    <name>A0A103RK52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007778">
        <property type="protein sequence ID" value="KVG69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103RK52"/>
    <dbReference type="Gramene" id="KVG69287">
        <property type="protein sequence ID" value="KVG69287"/>
        <property type="gene ID" value="Ccrd_026271"/>
    </dbReference>
    <dbReference type="OMA" id="NNIGVXV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="02CFF6D22C5AC645" modified="2016-04-13" version="1">MAFLTNASIDLLLRFSRPGKSISYGGVMVDAFGRIGRLLLQVCVLVNNIGVXVVYMIIIGMARLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WSS8</accession>
    <name>A0A103WSS8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Photosystem I reaction center subunit psaK, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PSI-K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Photosystem I subunit X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_025524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PsaG/PsaK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006493">
        <property type="protein sequence ID" value="KVH77824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WSS8"/>
    <dbReference type="STRING" id="59895.A0A103WSS8"/>
    <dbReference type="Gramene" id="KVH77824">
        <property type="protein sequence ID" value="KVH77824"/>
        <property type="gene ID" value="Ccrd_025524"/>
    </dbReference>
    <dbReference type="OMA" id="VKADWSI"/>
    <dbReference type="OrthoDB" id="1904255at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.40:FF:000001">
        <property type="entry name" value="Photosystem I reaction center subunit psaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.40">
        <property type="entry name" value="Chlorophyll a-b binding protein like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035982">
        <property type="entry name" value="PSI_centre_PsaK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000549">
        <property type="entry name" value="PSI_PsaG/PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023618">
        <property type="entry name" value="PSI_PsaG/PsaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016370">
        <property type="entry name" value="PSI_PsaG/PsaK_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017493">
        <property type="entry name" value="PSI_PsaK_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03050">
        <property type="entry name" value="PS_I_psaK_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34195:SF2">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT PSAK, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34195">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT V, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01241">
        <property type="entry name" value="PSI_PSAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002912">
        <property type="entry name" value="PSI_PsaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81563">
        <property type="entry name" value="Photosystem I reaction center subunit X, PsaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01026">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH77824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="136" mass="13753" checksum="CFEFF08D7565CB04" modified="2016-04-13" version="1">MATAVMASLPRFTGLRPSSSSTSPIQSTVSFQPMKPKGKGKGKGNGALGVRCDFIGSSTNLIMVTSTTLMLFAGRFGLAPSANRKATAGLKLEVRDSGLQTGDPAGFTLADTLACGTVGHIIGVGVVLGLKNIGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WST4</accession>
    <name>A0A103WST4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_025519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006488">
        <property type="protein sequence ID" value="KVH77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WST4"/>
    <dbReference type="STRING" id="59895.A0A103WST4"/>
    <dbReference type="Gramene" id="KVH77873">
        <property type="protein sequence ID" value="KVH77873"/>
        <property type="gene ID" value="Ccrd_025519"/>
    </dbReference>
    <dbReference type="OMA" id="VRSICIN"/>
    <dbReference type="OrthoDB" id="1258937at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF63">
        <property type="entry name" value="OS01G0937200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118612" evidence="3">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="48132" checksum="7502032E41FDBB10" modified="2016-04-13" version="1">MIFLLQLIVVVVVLISHEHEAIAQFVPPYSSVVMPVNKHTDAAKPLYSVEIMTSYVNMQYMRAKFLIDMDAPFIWHDCILKWNTFQDSCPPNTLCTYPVSCEEYQCTDVRTTYSYENPSCPPVNNGSTLPGWGYCTCPVTVVDPVTGSCGEAMLDYDEFTVNTSNGRNVFTGLYGAYPNAACAPSSSFASFPANVSGVMALSSSPYAFPAYLYQPLSRIIALCLPSTLSSSGLLFYGNSSYHLLPQSNVDIRSLLSYTPLIKRPGSFGYFIGVNAIVIKTRSIQLLENTTTKLSTIDPYTTMRTDIYKWVVRRFSLVTKRIPLAAPVAPFGLCFSTFTNGTRVSLRVPDIDISINDGKKWSISTANSIKQITEDVACLAFVDGGATSEPAIVIGTFQFEDNFLMFDLENSTFGFSSSLLRKKTSCSNFNFTLTESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDE2</accession>
    <name>A0A103XDE2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005348">
        <property type="protein sequence ID" value="KVH88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDE2"/>
    <dbReference type="Gramene" id="KVH88695">
        <property type="protein sequence ID" value="KVH88695"/>
        <property type="gene ID" value="Ccrd_026052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121">
        <property type="entry name" value="HOMEODOMAIN PROTEIN 8, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7730" checksum="CA587B2C090A1D3A" modified="2016-04-13" version="1">MATRAAGMMFHCVFEGSLSMSEMDKEQRPYHKNCNCACIRQNMKPQELVPIMGEFLTQRNHHGTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDP0</accession>
    <name>A0A103XDP0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_025287</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005330">
        <property type="protein sequence ID" value="KVH88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDP0"/>
    <dbReference type="Gramene" id="KVH88828">
        <property type="protein sequence ID" value="KVH88828"/>
        <property type="gene ID" value="Ccrd_025287"/>
    </dbReference>
    <dbReference type="OMA" id="FPIMIAY"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000008">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118699" description="glucan endo-1,3-beta-D-glucosidase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="18">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="501" mass="55503" checksum="8C675C33CD0AF23F" modified="2016-04-13" version="1">MATNPCQFIITLLLMICFSAPFMAIVNCSDSDSDSSPSTGVGVNWGTMTSHQLPAEQVVEMMRENGFKKVKLFEAEKRIMEALIGSEIEVMVAIPNFMLLDMSQDPSYADYWVDSNITTYAYPGGVDIKYVAVGNEPFLKAYNATYLQITLPALKNVQNALNRAGLGSQIKATVPLNADIYESPESNPVPSAGDFRSEIKDATIEIIQFLYSNDAPFTVNIYPFLSLYGNEYFPMDFAFFDGSNKPVKDKNYLYTNVFDANYDTLVASLTKAGYPEMKIVVGEIGWPTDGDINANVKNAKRFNQGVIKHVLSSKGTPVRKGPLEIYLFSLLDENKKSIAPGSFETHWGIFEYDGKPKYELDLSGSKRNKGLSPVVGVRYMSRRWCVLNPRVKQLDGLAKEIDYACSLSDCTSLGYGSSCNRLSLSGNASYAFNMYYQLQDQNDWDCEFSGLAMVTGEDPSVGECRFPVMIAYGTSVVVHRKVLKVLLGVVEGCIVFLLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE07</accession>
    <name>A0A103XE07_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plant specific eukaryotic initiation factor 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005325">
        <property type="protein sequence ID" value="KVH88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE07"/>
    <dbReference type="STRING" id="59895.A0A103XE07"/>
    <dbReference type="Gramene" id="KVH88941">
        <property type="protein sequence ID" value="KVH88941"/>
        <property type="gene ID" value="Ccrd_024680"/>
    </dbReference>
    <dbReference type="OMA" id="WAMTKKP"/>
    <dbReference type="OrthoDB" id="2021148at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010433">
        <property type="entry name" value="EIF-4B_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32091">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32091:SF20">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06273">
        <property type="entry name" value="eIF-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="536" mass="58857" checksum="3BB074A2F782E983" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEB5</accession>
    <name>A0A103XEB5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_008850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005306">
        <property type="protein sequence ID" value="KVH89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEB5"/>
    <dbReference type="STRING" id="59895.A0A103XEB5"/>
    <dbReference type="Gramene" id="KVH89162">
        <property type="protein sequence ID" value="KVH89162"/>
        <property type="gene ID" value="Ccrd_008850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071618">
        <property type="term" value="F:lysophosphatidylethanolamine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF46">
        <property type="entry name" value="PLASMALOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="410" mass="46223" checksum="10F1162AD0DF8D33" modified="2016-04-13" version="1">MAAATDLRSPLLPSSNGSHRLQPTAVDARPSQVILTVNDGYSQSGTPTNQDSIRTATMMDMEDEFIIRRQENPYGVIGSDGFEAPGSTTVDPFRNQTPKIEGVYEWVKMLVILPIALVRLVLFGFYHWINRKGKPAPRDVAPILVSNHVSYIDPIFFFYELSPTIVASESHDSMPFVGTIIRAMQVIYVNRFSHQSRKHAVNEIKRKASSNRFPRVLLFPEGTTTNGRQLISFQLGAFLPGYPIQPVVIRYPHVEYLPVMAPSQHHKESAARFAERTGRAMASALNVKSLSPFMVEMTKIQKIFGFIDVDKNGVITFKEFLVGSAHILKLPVFRRACEMAFTQSDENKDHYISIQEMHTLFNLFDTDGDGKISKDDFMTCLRRNPLLIALFLHHFIDKDLTAETGSDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEW5</accession>
    <name>A0A103XEW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Senescence regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEW5"/>
    <dbReference type="STRING" id="59895.A0A103XEW5"/>
    <dbReference type="Gramene" id="KVH89436">
        <property type="protein sequence ID" value="KVH89436"/>
        <property type="gene ID" value="Ccrd_008581"/>
    </dbReference>
    <dbReference type="OMA" id="HVEMEYS"/>
    <dbReference type="OrthoDB" id="672058at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083:SF49">
        <property type="entry name" value="SENESCENCE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15406" checksum="31AB9FBBAFC6BE8A" modified="2016-04-13" version="1">MAEEFEESDVVFTGNNDYEDGDHHCFVKCFGDSDSEESRGAKRKKIDKKISTKKAKAKAKAVNIPEIFSWFHVMEPSLFEHEEGEMIPPHVMVLRRRVAEKMAFSVCSGMGRTLKGRDLSEVRNCVLRMTGFLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG40</accession>
    <name>A0A103XG40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_007872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005117">
        <property type="protein sequence ID" value="KVH90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG40"/>
    <dbReference type="Gramene" id="KVH90135">
        <property type="protein sequence ID" value="KVH90135"/>
        <property type="gene ID" value="Ccrd_007872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33698:SF1">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33698">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="17207" checksum="94E3FA5B1FF7B76C" modified="2016-04-13" version="1">MATKMQFSGLSRLLSTHKQETDRHGMQQLHMNMRDERVCYRNCNLTKAMSSMIGDSVRAPDPTPSDTIKQFYECMNEKNIKLLEDYISNDCFFEDYSFPKPFNGKKVRPFGSNLRVRPLQGAMKDIGKEVDDGRHWLPSRRIGTGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGI5</accession>
    <name>A0A103XGI5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ELK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TALE/KNOX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGI5"/>
    <dbReference type="Gramene" id="KVH90269">
        <property type="protein sequence ID" value="KVH90269"/>
        <property type="gene ID" value="Ccrd_007740"/>
    </dbReference>
    <dbReference type="OMA" id="HAMEAVY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000143">
        <property type="entry name" value="homeobox protein knotted-1-like 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005540">
        <property type="entry name" value="KNOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005541">
        <property type="entry name" value="KNOX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03789">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03790">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03791">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01255">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01256">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51213">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="371"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="5">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="451" mass="50322" checksum="3D136AA6391514EF" modified="2016-04-13" version="1">MAFHPNHLSQEMALQQHFSDTDNNSVLRTILPDHHHHHLAVAAQSSPSSRSVGKDHWLNSAILRQQNQYGAGAADGGNNFLNLQTNNNSESAITTSSQLHHQQHTGNNNNQWLSRSMMQRNVSDVRGDDIVSQVSNDSIIAAMSSHDSPDLNNQSRSVVASQVDNNGGESEVGGGEGALVNWQNARHKAEVLSHPLYEQLLSAHVACLRIATPVDQLPRIDAQLAQSQHVVSKYSALGGHANLGDDKELDQFMTHYVLLLCSFKEQLQQHVRVHAMEAVMACWEIEQSLQSLTGVSPGEGTGATMSDDDEDQVESDANLFDGSLDGHDSMGFGPLVPTESERSLMERVRQELKHELKQGYKEKIVDIREEILRKRRAGKLPGDTTSVLKSWWQSHAKWPYPTEEDKARLVQETGLQLKQINNWFINQRKRNWHTNPSSSSSSTVLKTKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH35</accession>
    <name>A0A103XH35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH35"/>
    <dbReference type="STRING" id="59895.A0A103XH35"/>
    <dbReference type="Gramene" id="KVH90646">
        <property type="protein sequence ID" value="KVH90646"/>
        <property type="gene ID" value="Ccrd_007347"/>
    </dbReference>
    <dbReference type="OMA" id="YHKAHDF"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF24">
        <property type="entry name" value="OS07G0573800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="111"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="264"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="37821" checksum="27387C2520C5F1B7" modified="2016-04-13" version="1">MKTLVAPSTLRCSISSATSRIHDLDRLLIYKNGRISSSCGITPPLLSHSRSSYIFSATSTSRRRPPISAMASSTQAPSQSASSGDATADVFELIKAHQERAARLPPIEEVKTILHHGMRGVLSTFSQKHDGYPSGSMVDFACDAYGSPILAVSSLAVHTKDLLANSKCSLLVAKDPEDRTDLVIIVHGDAVSVPNEDTDIIRTAYLARHPDAFWVDFGDFQFLRIEPKVVRFVSGVATALLGSGEFTKEEFRAAKVDPISQFSKPVTSHMNKDHSDDTKLMVQHSTSVPVDFAHMLDMDSLGFNVKAGYQGRSFKLRIPFPRQAEDRKDVKTLIVEMLQAAKSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHB3</accession>
    <name>A0A103XHB3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nucleotide-binding, alpha-beta plait</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_007276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHB3"/>
    <dbReference type="STRING" id="59895.A0A103XHB3"/>
    <dbReference type="Gramene" id="KVH90692">
        <property type="protein sequence ID" value="KVH90692"/>
        <property type="gene ID" value="Ccrd_007276"/>
    </dbReference>
    <dbReference type="OMA" id="XAVSDVE"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12539">
        <property type="entry name" value="RRM_U2AF35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="187"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH90692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="37926" checksum="25F935C4FF19A4AC" modified="2016-04-13" version="1">MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHTKPSISPTLLLSNMYQRPDMITPGVDAQGNPIDPRKIQDHFEDFYEDLFEELNKYGEIESLNVCDNLADHMVGNVYVQFREEEYAAKALKNLSGRYYAGRPIIVDFSPVTDFREATCRQYEENTCNRGGYCNFMHLKRIGRELRRQLFGRYRRRHSRSPSRSRSPYRHRSYDERGHGSRSHSRRYDDRDRDYHHESRSRRHRSTSPLHRRERSRSSEGRRHHSPVREGSEERRAKIEQWNRQREQAKLSETNDDGVENNYESDNYTGKGDGYYNQQSEQYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHC6</accession>
    <name>A0A103XHC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Senescence regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHC6"/>
    <dbReference type="STRING" id="59895.A0A103XHC6"/>
    <dbReference type="Gramene" id="KVH90771">
        <property type="protein sequence ID" value="KVH90771"/>
        <property type="gene ID" value="Ccrd_007217"/>
    </dbReference>
    <dbReference type="OMA" id="MARTRIV"/>
    <dbReference type="OrthoDB" id="1917735at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525">
        <property type="entry name" value="EMB|CAB72159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525:SF2">
        <property type="entry name" value="EMB|CAB72159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="18778" checksum="0AD12C811F188195" modified="2016-04-13" version="1">MAASKSYYARANYRYLSSERDGPVGTDSMFELDESDVWNVSSSPELRKTVPSSRISKKSSSAVVKRGEIGGTASSLPVNVPDWSKILKEDYRGNRRRDNDDVDDFDQNDYGEDGNGNRIPPHEFLAKQLARTRIASFSVHEGIGRTLKGRDLSRVRNAIWEKTGFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIE3</accession>
    <name>A0A103XIE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005046">
        <property type="protein sequence ID" value="KVH91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIE3"/>
    <dbReference type="STRING" id="59895.A0A103XIE3"/>
    <dbReference type="Gramene" id="KVH91333">
        <property type="protein sequence ID" value="KVH91333"/>
        <property type="gene ID" value="Ccrd_006642"/>
    </dbReference>
    <dbReference type="OMA" id="DNIMESE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1346">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23350" checksum="FE985D80AF02678A" modified="2016-04-13" version="1">MMASLAKDFHPCGFESLYITSTPNREKRSRYRMGRAPCCEKMGLKRGPWSHEEDQLLIAYIKQHGHPNWRALPKHAETTGSQCLVQPDHNSLDKVRSVSYQPSTSESSSITEATNELPSVTKHEETNHEMFLDDSFWSETLSGVGDNNMESDPAKSIPGVEFPTSLLTMIENTDTRNPNTGCNMDGIDLWSDIFMHIEDFNSMHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIL0</accession>
    <name>A0A103XIL0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_006564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005012">
        <property type="protein sequence ID" value="KVH91413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIL0"/>
    <dbReference type="Gramene" id="KVH91413">
        <property type="protein sequence ID" value="KVH91413"/>
        <property type="gene ID" value="Ccrd_006564"/>
    </dbReference>
    <dbReference type="OMA" id="TKRPEYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF840">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 60-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="111"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH91413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="50385" checksum="053E0B7BF9CC6011" modified="2016-04-13" version="1">MSPGMVWKLDPSQKERRKWFFKDKYKLCPMFCNSGVAVQSSSTANRIAFRLVFNQTDKGFEGSSAPLVKIWGHTSALLKQTSSLKMVRMGGSDMVYHQCKGGVHQWKILIDHRFDFLQRLHRPKRFDSNFLVHAALPDLDPSTSFFGVYDGHGGKVVAKFCAKYLHQQVLKHEAYSTGNIETSVQKAFIRMDDMMRGQRGWRELSVLGDRINKFTGVIEGLIWSPRGGEGSHQVDDWAFEEGPHSDFTGPTSGCTACVAIIRNNQLIVANAGDSRCVISRKGEAYNLSRDHKPGLEIERERILKAGGFIHSGRVNGSLNLTRAIGDMEFKQNKFLSAEKQIVTANPDVNTVELCDDDDFIVLACDGIWDCMSSQQLVDFIHEQLNSESKLSSICERVFDRCLAPSTTTGEGCDNMTMILVQFKKPIQPSAAAAEPDLDGKLKTAAAGNESDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJC9</accession>
    <name>A0A103XJC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJC9"/>
    <dbReference type="STRING" id="59895.A0A103XJC9"/>
    <dbReference type="Gramene" id="KVH91833">
        <property type="protein sequence ID" value="KVH91833"/>
        <property type="gene ID" value="Ccrd_006170"/>
    </dbReference>
    <dbReference type="OMA" id="IMPRENS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF70">
        <property type="entry name" value="TRANSFERASE, CHLORAMPHENICOL ACETYLTRANSFERASE-LIKE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="51267" checksum="C3FFDEA3452E4931" modified="2016-04-13" version="1">MTMSWNSYVRTPIPHAPFTKIHRVNVFMAMKTEIQSRKLIKPSISTPPSLRSYKISFVDELAPSMNISLVLFFPHNTDYNPTQLEKSLEKTLTLMYPLAGRYMADVRTVDCNDQGVEFVQAQADTTIQEILDFKLKVDPNLINQFIPSKLLADGPTDAVLATQLTAFECGGSALGVSIAHRIGDVSTMSAFLNQWATLSRKDAKVETGLITSFSSFPAQDSPFIEQGFTKLNDNGYVTKKLSFDENAISNMRMKATSNGKTDNRQLFKVQLVSALIWKAFIGVDHAIYGHSRDSVALQPTKLRQKTRSSLPRSISIGNQWGPIVTERNTTKKVELGFEDLIDLLGDSVMKTMKEYSKLGHDDSQERKEMVLKSFSQIRNISNDRNVVWLVSWCRFPYYDVDFGFGKPEWISCGCVPFKRGVIMVDDAGGNGVEAYVSMGVADVRHFEQDEDIKAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMH7</accession>
    <name>A0A103XMH7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_004537</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="LEKV01004771">
        <property type="protein sequence ID" value="KVH93413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMH7"/>
    <dbReference type="STRING" id="59895.A0A103XMH7"/>
    <dbReference type="Gramene" id="KVH93413">
        <property type="protein sequence ID" value="KVH93413"/>
        <property type="gene ID" value="Ccrd_004537"/>
    </dbReference>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118926" description="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" evidence="21">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH93413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="252" mass="28298" checksum="9B60DE5E9D0F4F89" modified="2016-04-13" version="1">MMTIVVVVAVTTLGVGDGYDNKQQRPGGDNGDRCSYGNNLTVVAVMKVGYIRVLMNCFAFGICFSNKELFSILYFISFVCDALDGWFARKFNQVSTFGAVLDMVTDRISTACLLVILSQVYRPSFVFLSLLALDIASHWLQMYSTFLVGKSNHKDVKDSTSWLFKLYYGNRMFMGYCCIACEVLYITLFLLAKENEKMIDVLMGAAQQSIIYSALLALLLFGWAIKQLVNIIQMKTAADLCVLYDLNKKHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMI1</accession>
    <name>A0A103XMI1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004755">
        <property type="protein sequence ID" value="KVH93511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMI1"/>
    <dbReference type="STRING" id="59895.A0A103XMI1"/>
    <dbReference type="Gramene" id="KVH93511">
        <property type="protein sequence ID" value="KVH93511"/>
        <property type="gene ID" value="Ccrd_004438"/>
    </dbReference>
    <dbReference type="OMA" id="NAIQHHR"/>
    <dbReference type="OrthoDB" id="1878267at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044797">
        <property type="entry name" value="At4g06598-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835:SF3">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="42064" checksum="2D92C0CFC96A2854" modified="2016-04-13" version="1">MENSKGPSTMRNMYSGKHYSLPPKSPFPSVAPFYADYAPTAVSGPKGVPKYKDGNSHHQRTSSESLLIEEQPSWLDELLDEPETPVRRGHRRSSSDSFTYMEAANANIERAAQVEYRLRNMNSAPSWGSQDFDLYKDARNASFYAEHSPLIKKNQAWDSPQNALAHSSGTASLRDSLVLQNSTTSGASQEVKKIASVTTEKQDTVESCTQDSHTSFERNDASNTKASASETDTKRAKQQFAQRSRVRKLQYIAELERNVQALQAEGSEVSAELKFINQRSLILSMENKALKQRLDNLAQEQLIKYLEHEVLEREIGRLRTLYKQQQQPPTEQPILSHHRHTNSRDSVESQFANLSLKNKESGAVRDAVSGPLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNV5</accession>
    <name>A0A103XNV5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004568">
        <property type="protein sequence ID" value="KVH94125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNV5"/>
    <dbReference type="Gramene" id="KVH94125">
        <property type="protein sequence ID" value="KVH94125"/>
        <property type="gene ID" value="Ccrd_003799"/>
    </dbReference>
    <dbReference type="OMA" id="EMPQDPE"/>
    <dbReference type="OrthoDB" id="1924020at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051861">
        <property type="entry name" value="NET_actin-binding_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258:SF3">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07765">
        <property type="entry name" value="KIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51774">
        <property type="entry name" value="NAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="50835" checksum="0889D4B23766241B" modified="2016-04-13" version="1">MSNRGMTKKFLISEMDRSVKRMLQLIEEEGDSFAKKAEIYYQKRPLLVAQVEDFYGMFRLLAERIENPAPGDVKRTVPTDLRKQNSGGISDFCSEPPSRMHSPTDNRLTRRLSGTRPGGFDFIGNKDGDENWMMESESDSDDSSIFNYSSASTYPSYRRLRRRINELESELRRVQIIQEVNGVASLQEELRLVKDKLRSSEEQIGKLKLKLAEKYESQRSNDKDSKTSSVCNDSDRVYGSDQSENRDVSKLEAQISRYKSSLTERDQEILKLRNQVTNLLKERAFRIKEWGLQHEMGMKRTEIEDEMGLKKTELEDEIEELKIERDGLVAKVSDLEEEMSLKDDQIEHMHQRLQKLQSQYEKSSRSIEELGCRSRELEQVIEKQQEMIEEAAEDKRQAVRQLCITLEHYRNAYQMLRQDLKEQRKPVKFRSSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPI3</accession>
    <name>A0A103XPI3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPI3"/>
    <dbReference type="STRING" id="59895.A0A103XPI3"/>
    <dbReference type="Gramene" id="KVH94460">
        <property type="protein sequence ID" value="KVH94460"/>
        <property type="gene ID" value="Ccrd_003506"/>
    </dbReference>
    <dbReference type="OMA" id="HKKTRIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000009">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15028" checksum="E0BD273875CB9C55" modified="2016-04-13" version="1">MDSVKATKSVGGRGKPKSTKSVSRSSKAGLQFPVGRVSRYLKAGRYAKRVGSGSPVYLSAVLEYLAAEVLELAGNAARDNKKNRITPRHIQLAVRNDDELGKLLGKVTIANGGVLPKIHQTLLPSKKGKGKDEIGSASQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQV9</accession>
    <name>A0A103XQV9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XQV9"/>
    <dbReference type="Gramene" id="KVH95205">
        <property type="protein sequence ID" value="KVH95205"/>
        <property type="gene ID" value="Ccrd_002729"/>
    </dbReference>
    <dbReference type="OMA" id="CMESTTT"/>
    <dbReference type="OrthoDB" id="684567at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11448">
        <property type="entry name" value="bHLH_AtFAMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044283">
        <property type="entry name" value="FAMA/SPEECHLESS/MUTE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46684:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH67-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46684">
        <property type="entry name" value="TRANSCRIPTION FACTOR FAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="358" mass="40254" checksum="DD2E1036F416E32C" modified="2016-04-13" version="1">MALETLSSNELLNFIIYDTISATPFSCNDSSETTTTNTNPCSSFFFHLENQNPNPPLNQELSGAAAAMEIMTSNSSLTTTTAKMSMAVQAYCSGKIPEKNYSNNNNNNNNNQNLGVQGGGKKKRRRRPRVCKNKEEAETQRMTHIAVERNRRKQMNEHLAVLRSLMPESYVQRGDQASIVGGAIEFVKELEHLLQSLEAQKFLLTQQQQQQQQQQQQREEEDSDFADNTKLSSPLPPFSQFFSYPQYTCSQIPNKYTSKSKAAIADIEVTLIETHANLRILSQKRLTQLSKMVACFQTLHLSVLHLNITTLDPLVLYSISVKVEEGCRLNSADEIXGAVHQMLRIIEEEATLCVDSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRB0</accession>
    <name>A0A103XRB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, MIZ-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004390">
        <property type="protein sequence ID" value="KVH95431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRB0"/>
    <dbReference type="STRING" id="59895.A0A103XRB0"/>
    <dbReference type="Gramene" id="KVH95431">
        <property type="protein sequence ID" value="KVH95431"/>
        <property type="gene ID" value="Ccrd_002560"/>
    </dbReference>
    <dbReference type="OMA" id="QVRNNAT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="830" mass="91007" checksum="0BC316DB4995E987" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTC3</accession>
    <name>A0A103XTC3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004290">
        <property type="protein sequence ID" value="KVH96478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTC3"/>
    <dbReference type="Gramene" id="KVH96478">
        <property type="protein sequence ID" value="KVH96478"/>
        <property type="gene ID" value="Ccrd_001436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119094" description="Nucleotide-binding, alpha-beta plait" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8845" checksum="7198B537FFB72DB0" modified="2016-04-13" version="1">MALKSPWAFSLPFLMSSSAIFTSPLQVQSFYMRNGSGGRGSSYSGDRVSTTISFEDLNAFHCLRNYLGDKGISIKNERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU49</accession>
    <name>A0A103XU49_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004026">
        <property type="protein sequence ID" value="KVH96936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XU49"/>
    <dbReference type="Gramene" id="KVH96936">
        <property type="protein sequence ID" value="KVH96936"/>
        <property type="gene ID" value="Ccrd_000971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="18860" checksum="2DBED854243DC0DF" modified="2016-04-13" version="1" fragment="single">LGFSYRTIIALISVFSIFSYRLPPQDLSPYQEEEAKRNAESCFVVLVATSTVLLCLKANMWVFRMPLXASRIKVLQAQDDLVSAMRETASKDLLNVGHYKSHHLHNYGLLRALIIQIQPYKFGTFYHMTWIFKNEAELLVKVKDHILVPEHHYLQLKKRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU64</accession>
    <name>A0A103XU64_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004111">
        <property type="protein sequence ID" value="KVH96900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU64"/>
    <dbReference type="STRING" id="59895.A0A103XU64"/>
    <dbReference type="Gramene" id="KVH96900">
        <property type="protein sequence ID" value="KVH96900"/>
        <property type="gene ID" value="Ccrd_001007"/>
    </dbReference>
    <dbReference type="OMA" id="MEVCKER"/>
    <dbReference type="OrthoDB" id="1907216at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040400">
        <property type="entry name" value="BAG5/6/7/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33322">
        <property type="entry name" value="BAG DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33322:SF8">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="199" mass="22593" checksum="1937131BD85875C4" modified="2016-04-13" version="1">MKSSCRIRSCSSADGATTTNTFKGDNSQTNSTEIPITFHLSNHESTAAVKIQSAYRSHAIRNLTNKIKAVNSEADKLQRLIQLQETVDAVRTNNRDRIKMNEALMRLLFTLDSVPGLDPTVREFRRNVSRRIVGLQEILDSICEAGEANWDGFLRDWDDVIMGIEHEICKEKGGADSHEFERFCAENLGFQCLQRFLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUJ5</accession>
    <name>A0A103XUJ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_000805</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003860">
        <property type="protein sequence ID" value="KVH97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XUJ5"/>
    <dbReference type="Gramene" id="KVH97095">
        <property type="protein sequence ID" value="KVH97095"/>
        <property type="gene ID" value="Ccrd_000805"/>
    </dbReference>
    <dbReference type="OMA" id="NYCEAAI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="22">
        <location>
            <begin position="446"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="1018"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="1117"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="24">
        <location>
            <begin position="1194"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVH97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1401" mass="155964" checksum="B3489CD0E9F8F7DB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVN7</accession>
    <name>A0A103XVN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Argonaute/Dicer protein, PAZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVN7"/>
    <dbReference type="STRING" id="59895.A0A103XVN7"/>
    <dbReference type="Gramene" id="KVH97723">
        <property type="protein sequence ID" value="KVH97723"/>
        <property type="gene ID" value="Ccrd_000167"/>
    </dbReference>
    <dbReference type="OMA" id="FARCTRP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000110">
        <property type="entry name" value="Argonaute 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000008">
        <property type="entry name" value="Protein argonaute 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="8">
        <location>
            <begin position="274"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="9">
        <location>
            <begin position="534"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="877" mass="99168" checksum="B18A3DBFD4FD5A8B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVT6</accession>
    <name>A0A103XVT6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003818">
        <property type="protein sequence ID" value="KVH97798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVT6"/>
    <dbReference type="STRING" id="59895.A0A103XVT6"/>
    <dbReference type="Gramene" id="KVH97798">
        <property type="protein sequence ID" value="KVH97798"/>
        <property type="gene ID" value="Ccrd_000070"/>
    </dbReference>
    <dbReference type="OMA" id="IQRENDV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005540">
        <property type="entry name" value="KNOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005541">
        <property type="entry name" value="KNOX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03790">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03791">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01255">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01256">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="33631" checksum="9D2018C70A39E88A" modified="2016-04-13" version="1">MEEMYGFNSMSDYTISPETNLISSSEYHGVTSTSVDHYRTFYGSDNLLSAAASVISEAVSLAATPHQILLPRTRSSRQRDQNKNDSDHHHVDVCDDIIKAKIASHPLYPKLLDAFIDCQKLGAPPEIASLLDEIRRENDVRLRNAASSTCLVADPELDEFMETYCQVLVKYKSDLARPFDEATVFLNNIETQLSNLCKGIRIYTVDDDGTVSSEEEFSGGETENTQVSREEQELKDTLLRKFGGHITDKIALAESTGLDQKQINNWFINQRKRHWKPSENMQLAIMGSFSGNQDFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW48</accession>
    <name>A0A103XW48_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photosystem I reaction center subunit VI</fullName>
            <shortName evidence="13">PSI-H</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_023789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Docking of the LHC I antenna complex to the core complex.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Possible role could be the docking of the LHC I antenna complex to the core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Plastid</location>
            <location evidence="2 13">Chloroplast thylakoid membrane</location>
            <topology evidence="2 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the psaH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW48"/>
    <dbReference type="STRING" id="59895.A0A103XW48"/>
    <dbReference type="Gramene" id="KVH97963">
        <property type="protein sequence ID" value="KVH97963"/>
        <property type="gene ID" value="Ccrd_023789"/>
    </dbReference>
    <dbReference type="OMA" id="HPSYISY"/>
    <dbReference type="OrthoDB" id="496139at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.220:FF:000003">
        <property type="entry name" value="Photosystem I reaction center subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004928">
        <property type="entry name" value="PSI_PsaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_pept_SipW-depend-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34787">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT VI-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34787:SF1">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT VI-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03244">
        <property type="entry name" value="PSI_PsaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="6 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH97963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="15209" checksum="EF97C66DB62400B0" modified="2016-04-13" version="1">MASLTTSAPPAAATIKGLGGSSLAGTKLSLKPSRLSFRPTSSYRAGAVVAKYGDKSVYFDLEDLGNTTGQWDVYGSDAPSPYNPLQSKFFETFAAPFTKRGLLLKFLILGGGSTLAYFSSTATGDVLPIVKGPQEKPKLGPRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXV9</accession>
    <name>A0A103XXV9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXV9"/>
    <dbReference type="Gramene" id="KVH98916">
        <property type="protein sequence ID" value="KVH98916"/>
        <property type="gene ID" value="Ccrd_022816"/>
    </dbReference>
    <dbReference type="OMA" id="QKYRIAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044511">
        <property type="entry name" value="At1g03370/At5g50170-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46296">
        <property type="entry name" value="BNAA05G37250D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46296:SF7">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="5">
        <location>
            <begin position="230"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="467"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="5">
        <location>
            <begin position="751"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="919" mass="104171" checksum="BC2C116E86BE6106" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0S0</accession>
    <name>A0A103Y0S0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0S0"/>
    <dbReference type="STRING" id="59895.A0A103Y0S0"/>
    <dbReference type="Gramene" id="KVI00432">
        <property type="protein sequence ID" value="KVI00432"/>
        <property type="gene ID" value="Ccrd_021412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22009">
        <property type="entry name" value="HMG-box_AtHMGB9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000055">
        <property type="entry name" value="High mobility group B protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46691:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46691">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="414" mass="46305" checksum="D19CA2BB63A53E70" modified="2016-04-13" version="1">MGPPHSHANVVCAFAASPEPSIGFPVTGIIDGKFESGYLCTVMIGGEPLQGILYQCNGHPSYQTSDHHGVVTQGQTTSGNAARPSTMVRRRRRKKSEIKKRDPAHPKPNRSGYNFFFAEQHARLKPLHPGKDRDISRMIGELWNNLTDSKKAVYQEKAMKDKERYRIEMEHYRESLRTGRLVSNAVPLLQQLFKRDVNMMEFNETFETDGGVSPQTPENELTSGDKSSFEDEGKTADTDSNFGLPLVGAEIASMQTVSGGLMKTVIGGEEFPRDIEMDPKESNQQESISVHKNESKHDEKSRHDEPTMPVTIDENEKKHQFASMLEKMPVEFDGTVEHRTLAVEELEQVTSETQVQYEPKPLDPIESAAVSMNLEQEPHVLQENIPKVIDDGAQIEAAPTNEVELRPPEGRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1W8</accession>
    <name>A0A103Y1W8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dormancyauxin associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DRM1/ARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003147">
        <property type="protein sequence ID" value="KVI01004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1W8"/>
    <dbReference type="STRING" id="59895.A0A103Y1W8"/>
    <dbReference type="Gramene" id="KVI01004">
        <property type="protein sequence ID" value="KVI01004"/>
        <property type="gene ID" value="Ccrd_020731"/>
    </dbReference>
    <dbReference type="OMA" id="TIGAEMF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008406">
        <property type="entry name" value="DRM/ARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33565">
        <property type="entry name" value="DORMANCY-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33565:SF2">
        <property type="entry name" value="DORMANCY-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05564">
        <property type="entry name" value="Auxin_repressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="106" mass="11307" checksum="55A3A358D755E527" modified="2016-04-13" version="1">MVLFDQMWDEVVAGPQPNRGLGKLRKLATFSGRDGLDGSSSNSGSISVPSSPTTPGTPTNTSPTAARKDNVWRSVFNPGSNPATRDIGSNRFDKPNNPGSPTIYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y210</accession>
    <name>A0A103Y210_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003135">
        <property type="protein sequence ID" value="KVI01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y210"/>
    <dbReference type="STRING" id="59895.A0A103Y210"/>
    <dbReference type="Gramene" id="KVI01062">
        <property type="protein sequence ID" value="KVI01062"/>
        <property type="gene ID" value="Ccrd_020673"/>
    </dbReference>
    <dbReference type="OMA" id="SDHMIFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051871">
        <property type="entry name" value="GMC_Oxidoreductase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968:SF3">
        <property type="entry name" value="OS04G0573100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968">
        <property type="entry name" value="OSJNBA0019K04.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="445"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="485"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="383"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="511" mass="56094" checksum="DFA5219D5C4BB9FE" modified="2016-04-13" version="1">MHEATKAPKISYYDYIVIGGGTTGIPIATSLSQNYSVLLLERGASPYGNPNVTKKANFGSYFSDNSPDSPSQRFVSVDGVTNARPRVLGGGTSINAGFYSHGDARFIKQAKLKDEWLINESYRWVEKVMVSKPVLTRWHSALESALVEADVTPENGFTYDHIIGTKVGGTIFDQNGTRHTAADLLQYANPKGLRLLLHATAHKILFKTKERSKPTAYGVVYEDASGKKHRAYLKGGQRDEIILSAGALGSPQLLMLSGVGPKDQLHTHNIKRVLHHPLIGQGMVDNPLNEFFVPSPIPVAQSLVDIVGITQSGNYIEAVEGFNLIGGTDSDYQGFSYEMGGFIFEKVNYPKSKGDLKLTNRNPADNPSVTFNYFKEPNDLRKCVLGLRTMLTAIESKSFAKFKYANMTIQDILDLNMKMPTTFPMNADTSSSLEQYCKDNVKTIWHYHGGCQMGKVVDADYKILGVDAVRVIDGSTLTSSPGTNPQASLLMLGRYMGVTILNKRLASDISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2P5</accession>
    <name>A0A103Y2P5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mediator of RNA polymerase II transcription subunit 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_020306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003100">
        <property type="protein sequence ID" value="KVI01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2P5"/>
    <dbReference type="STRING" id="59895.A0A103Y2P5"/>
    <dbReference type="Gramene" id="KVI01417">
        <property type="protein sequence ID" value="KVI01417"/>
        <property type="gene ID" value="Ccrd_020306"/>
    </dbReference>
    <dbReference type="OMA" id="MIDVERH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034456">
        <property type="entry name" value="MED28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39117">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39117:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="10053" checksum="7DBEC3EB4657EE9F" modified="2016-04-13" version="1">MIDVERHARDFMEAAKKLQLYFIGLQREDQPTKEEILQKDIAMMEEEVKTKTDLIKKQERLIQGWRKELKDQLEKHNAELERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y620</accession>
    <name>A0A103Y620_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyprenyl synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002435">
        <property type="protein sequence ID" value="KVI03169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y620"/>
    <dbReference type="STRING" id="59895.A0A103Y620"/>
    <dbReference type="Gramene" id="KVI03169">
        <property type="protein sequence ID" value="KVI03169"/>
        <property type="gene ID" value="Ccrd_018535"/>
    </dbReference>
    <dbReference type="OMA" id="YHLAHYI"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000001">
        <property type="entry name" value="Geranylgeranyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053378">
        <property type="entry name" value="Prenyl_diphosphate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045485">
        <property type="entry name" value="FPPsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281:SF1">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39313" checksum="7928BB2D164B9B70" modified="2016-04-13" version="1">MTLLSFLSIKDNSLYLQNIFTNLPKNSTKCPRRTCLPLRIHASSSPPQIILQQLLPESNLVRFAPLKAFNFNTYMTEKAKIVNKALEEAVPLQEPLKIHEAMRYSLLAGGKRVRPVLCLASCELVGGMEVCAMAMASAVEMVHTMSLIHDDLPCMDNDDLRRGKPTNHKVYGEETAVLAGDALLSLAFEHLATRTVGVGPGRVVQAIGELGSAVGSLGLVAGQIVDLCSEGKKDVDLSQLEYIHIHKTAKLLEAAVVGGAVLGGGNSGEVERVRKYARCIGLLFQVVDDILDVTKSSEELGKTAGKDLLRDKATYPKLMGLERAKEFAGELLGNAVDELAYFDAGKAAPLYHLAHYIAYRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6B9</accession>
    <name>A0A103Y6B9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002369">
        <property type="protein sequence ID" value="KVI03326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6B9"/>
    <dbReference type="Gramene" id="KVI03326">
        <property type="protein sequence ID" value="KVI03326"/>
        <property type="gene ID" value="Ccrd_018381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="70" mass="8051" checksum="6ED2739A0BD839FD" modified="2016-04-13" version="1">MVEAVVVVAVKRRYKKTYIKHYRTLFVEKILLLGFEEDESRVSERLDLFDTSTHGSSGYDTSDSFIGLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6N0</accession>
    <name>A0A103Y6N0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002347">
        <property type="protein sequence ID" value="KVI03521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6N0"/>
    <dbReference type="STRING" id="59895.A0A103Y6N0"/>
    <dbReference type="Gramene" id="KVI03521">
        <property type="protein sequence ID" value="KVI03521"/>
        <property type="gene ID" value="Ccrd_018190"/>
    </dbReference>
    <dbReference type="OMA" id="IHRCLAF"/>
    <dbReference type="OrthoDB" id="764594at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF38">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="66097" checksum="7CA0D7CFEFDF773F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6N4</accession>
    <name>A0A103Y6N4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002348">
        <property type="protein sequence ID" value="KVI03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6N4"/>
    <dbReference type="STRING" id="59895.A0A103Y6N4"/>
    <dbReference type="Gramene" id="KVI03490">
        <property type="protein sequence ID" value="KVI03490"/>
        <property type="gene ID" value="Ccrd_018203"/>
    </dbReference>
    <dbReference type="OMA" id="NPFVDDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055296">
        <property type="entry name" value="SRL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46087:SF18">
        <property type="entry name" value="ARMADILLO-TYPE FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46087">
        <property type="entry name" value="PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111395" checksum="ED85DFD9EC7456B4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8K8</accession>
    <name>A0A103Y8K8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002020">
        <property type="protein sequence ID" value="KVI04512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI04512">
        <property type="protein sequence ID" value="KVI04512"/>
        <property type="gene ID" value="Ccrd_017172"/>
    </dbReference>
    <dbReference type="OMA" id="TAKHCED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="40581" checksum="53104EC78814AA0C" modified="2016-04-13" version="1">MGETSTGSKYWVPSVDVKYKPKVGDSFESVESAEKMYRKYANEAGFDVRLSNKKINKLGRITSRFYVCSKEGRPQSKYFDSLDVLPGGRTIRNSNIKRSGCGACLKIHLVNEPNQYEVYKFVEQHNHILFNKEEMSFPVRKGNSTTLIIRMYFMVIKKKIENSYDCSCNCFVRNGILCRHALKVMLNDEVDRIPDKYILRRWRRDLVPVEWLPAXFRYGEVDAEKERLMSLAYSYFERILGRVRNEKDILTRFVDQLEQWDSKVDIELPLQSHTEETTASIKEFLGVSQPETVDVLPPTGIRNKGCGTGKRLISAAEKAISNRKKQKRKCRLCGQMATHDSRNCPKRDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8N0</accession>
    <name>A0A103Y8N0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001996">
        <property type="protein sequence ID" value="KVI04551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8N0"/>
    <dbReference type="Gramene" id="KVI04551">
        <property type="protein sequence ID" value="KVI04551"/>
        <property type="gene ID" value="Ccrd_017129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="30721" checksum="CFBB4C5E5BC1C843" modified="2016-04-13" version="1">MASSNHTPIKFNQASSVTCALALYPPIPVLFKKPDGTSGVVLTVITWVSIAMTDDDTCTDAFEGDEMEIKGSIRVNIYNLSRSLQLKVPAYFNYLNSLASLWPMNMICRNYKDNALSSNVYDESETIDEDLHRFSTSFMNIELSDEWDTLEEDSKYFDSSNPNEIKPFLVKYTPPESSKTKIEDIKPTGWNECDHKILYPKELFGYTLNPQELEEMEALLKKQGQLHESQIIYQDDLGNIRMTPKDEDLLDSFLSDSVESINFALMNEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8X9</accession>
    <name>A0A103Y8X9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001935">
        <property type="protein sequence ID" value="KVI04706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8X9"/>
    <dbReference type="STRING" id="59895.A0A103Y8X9"/>
    <dbReference type="Gramene" id="KVI04706">
        <property type="protein sequence ID" value="KVI04706"/>
        <property type="gene ID" value="Ccrd_016974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF9">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="10056" checksum="00D2C4BE5082FF70" modified="2016-04-13" version="1" fragment="single">MKLGDRKAAETENLEYSANSAYVKIILLPTLLALRMSFVLSIANNDLGLAVVNTIEGISSGATQVDVTINRIEERERDGNASLEEVSIMLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y909</accession>
    <name>A0A103Y909_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001919">
        <property type="protein sequence ID" value="KVI04754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y909"/>
    <dbReference type="Gramene" id="KVI04754">
        <property type="protein sequence ID" value="KVI04754"/>
        <property type="gene ID" value="Ccrd_016925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="186" mass="19978" checksum="25E83357AF6A5B30" modified="2016-04-13" version="1">MANTNFQSEDAQILSTSDPPVIPTTPNEEEGDVKRRKRGCNSEFYDLNDSATSNFAPIAPIAPRAVVPLWTMCAPPTTGFHGGTIFMIPPCGATGPTICHQPQLWAIPTGATPVLDVPQRPISNYISAMKPVVCIGGSAVDTPAVSSGSISTTRRREMVKDLSLEIGEKRELQFMEGCSTDKTPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9C9</accession>
    <name>A0A103Y9C9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001902">
        <property type="protein sequence ID" value="KVI04885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9C9"/>
    <dbReference type="STRING" id="59895.A0A103Y9C9"/>
    <dbReference type="Gramene" id="KVI04885">
        <property type="protein sequence ID" value="KVI04885"/>
        <property type="gene ID" value="Ccrd_016795"/>
    </dbReference>
    <dbReference type="OMA" id="GCYHAYI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF39">
        <property type="entry name" value="ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="539" mass="60321" checksum="BA2575E68196F300" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9V3</accession>
    <name>A0A103Y9V3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9V3"/>
    <dbReference type="STRING" id="59895.A0A103Y9V3"/>
    <dbReference type="Gramene" id="KVI05180">
        <property type="protein sequence ID" value="KVI05180"/>
        <property type="gene ID" value="Ccrd_016518"/>
    </dbReference>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF2">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME, CHLOROPLASTIC_AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="210"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="703" mass="80543" checksum="E21B1EA1A1851328" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAF9</accession>
    <name>A0A103YAF9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAF9"/>
    <dbReference type="STRING" id="59895.A0A103YAF9"/>
    <dbReference type="Gramene" id="KVI05457">
        <property type="protein sequence ID" value="KVI05457"/>
        <property type="gene ID" value="Ccrd_016235"/>
    </dbReference>
    <dbReference type="OMA" id="FMLFKKS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040358">
        <property type="entry name" value="At4g22758-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055482">
        <property type="entry name" value="DUF7054"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270">
        <property type="entry name" value="BNAC05G50380D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270:SF34">
        <property type="entry name" value="SENESCENCE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23156">
        <property type="entry name" value="DUF7054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7054" evidence="2">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="19105" checksum="9BE570920B2198FC" modified="2016-04-13" version="1">MLMYKQKKNPAGRGAANRLLISITVIGSAGPIRFVVNEEELVAAVMDTALKSYAREGRLPVLGSNINDFVLYCPIAGTEALSPLETIGSFGVRNFMLCKKPQQVEAVGDGKPVTVGITRKNSGSWKSWFNKSLSLKAGNNINEKDKRPGTNKVLDQNVRANNKNTTKSKYNEKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAZ4</accession>
    <name>A0A103YAZ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Remorin, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the remorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAZ4"/>
    <dbReference type="STRING" id="59895.A0A103YAZ4"/>
    <dbReference type="Gramene" id="KVI05764">
        <property type="protein sequence ID" value="KVI05764"/>
        <property type="gene ID" value="Ccrd_015933"/>
    </dbReference>
    <dbReference type="OMA" id="PQKEQDY"/>
    <dbReference type="OrthoDB" id="687404at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005516">
        <property type="entry name" value="Remorin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471:SF52">
        <property type="entry name" value="F12A21.28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471">
        <property type="entry name" value="OS02G0116800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03763">
        <property type="entry name" value="Remorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Remorin C-terminal" evidence="4">
        <location>
            <begin position="218"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="37039" checksum="0AB6C582DC2B5DC0" modified="2016-04-13" version="1">MRSIEDKGCLNHVSIQETSGGGANRGCSQHHHRTALGKPTPSKWDDAQKWLVKLSRGGEKTHWNTEPRNSNADDRRLIASASQKEHPSSEEDCRDGSMVNYGGIETKKVDCDDSAWRSSDHSGSIVRSICVRDMGTEMTPMASHEPSRTATPVRATTPAARSPIASGSSTPVRPCPNGGHTVDAGGTTRFGRERVELNGENVPENKTLDQDVKLNPLETRAVAWDDAERAKYMARYKREEVKIQAWENHEKRKAEMEMKRMEVKAERLKSRAQEKYTNKLASTRRIAEEKRAKAEVNLNEQAGKTSERADYIRRTGHLPSSFSIKLPSCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC41</accession>
    <name>A0A103YC41_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001832">
        <property type="protein sequence ID" value="KVI06355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC41"/>
    <dbReference type="STRING" id="59895.A0A103YC41"/>
    <dbReference type="Gramene" id="KVI06355">
        <property type="protein sequence ID" value="KVI06355"/>
        <property type="gene ID" value="Ccrd_015288"/>
    </dbReference>
    <dbReference type="OMA" id="NAPAREP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34778:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34778">
        <property type="entry name" value="OS02G0580700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="410" mass="46169" checksum="CAC222313ECD61EB" modified="2016-04-13" version="1">MDADERLTALKKAYADIILNTAKEAAARIMVSERKALRFEYELKNAKEDALQMLLRLKKMMDSKINEAAVASCTQQKKIEELEAQLQEAEDIVKDLREELRAVEMELERFSQSKEVKHPVQVDDASMGNVPRTSESIPFPPSEVQPNSNIDQTNKSQRLYNSLFPLKKSLIGNGDLPSIILRSKETELYRNGCTQRIRACERTQPDKELSFSLQMDDIKPESIVKEDEALDKLRKSPSLGVDSLCSMEEKEVILEQVKEMDVAAEDSCLTSPSSVKHPNDTAIQEISDEDLVRTCDSQSTIRVELIPTRLEKDESLQSVEAQVDPPLKISETKASETSEVPSQPMTDRVIKYTFQRKRKRGALINGCASSERNEENQKAQNLGLGKANLIGESTPEKIRLEQVARQFSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE15</accession>
    <name>A0A103YE15_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE15"/>
    <dbReference type="STRING" id="59895.A0A103YE15"/>
    <dbReference type="Gramene" id="KVI07356">
        <property type="protein sequence ID" value="KVI07356"/>
        <property type="gene ID" value="Ccrd_014340"/>
    </dbReference>
    <dbReference type="OMA" id="SWCERDG"/>
    <dbReference type="OrthoDB" id="1913441at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47712">
        <property type="entry name" value="OS09G0555300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47712:SF1">
        <property type="entry name" value="OS09G0555300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="561" mass="63882" checksum="F85134F8C2755710" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF77</accession>
    <name>A0A103YF77_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001426">
        <property type="protein sequence ID" value="KVI07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF77"/>
    <dbReference type="STRING" id="59895.A0A103YF77"/>
    <dbReference type="Gramene" id="KVI07984">
        <property type="protein sequence ID" value="KVI07984"/>
        <property type="gene ID" value="Ccrd_013650"/>
    </dbReference>
    <dbReference type="OMA" id="FQMRNTH"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000038">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="433" mass="46356" checksum="BD55ED7FA0A31B7A" modified="2016-04-13" version="1">MYGSGQAAGTVNCCIASAMSSLEEPLGMDKLPGLSTIDLFQRFSSNGCSTSRGDTGMGSCWIEQNTSSSSNSYEEDFEYEQEAFTWRHHARDIPENDVICRSQGRNYAAYGNRCDSRHLANLQHNSYCNDVCLQDITNKIFRGIPKYVKIVEVGARDGLQNEKNVVPTSVKVELIQRLLSAGLSVVEATSFVSPKWVPQLADARDVIEAFKSLDTARLPVLVPNLKGFEAAVAAGAKEIAVFASASESFSKSNINCTIEESLTRYRAVVQAATKLSIPVRGYVSCVIGCPVDGMIHPSKVAYVAKELHDMGCCEISLGDTVGIGTPAVMAVVPVEKLAVHFHDTYGQSLPNILVSLQMGISTVDSSIAGLGGCPYAKGASGNVATEDVVYMLDGLGIKTNVDLGKLLQTGEFICKHLGRPSGSKAAVAFTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG73</accession>
    <name>A0A103YG73_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA methylase, N-6 adenine-specific, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001116">
        <property type="protein sequence ID" value="KVI08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG73"/>
    <dbReference type="STRING" id="59895.A0A103YG73"/>
    <dbReference type="Gramene" id="KVI08470">
        <property type="protein sequence ID" value="KVI08470"/>
        <property type="gene ID" value="Ccrd_013160"/>
    </dbReference>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="7">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="252" mass="27889" checksum="1EB0AC2965330E1F" modified="2016-04-13" version="1">MPPRIAQIRLVSSHPQVYEPCDDSYALVDALLADRTKLLEHHPTICMEVGCGSGYVITSLALILGSEARNAYYFATDVNPYAATVTRETLEAHGVHAELVTTNIASGLEKRLSGLVDVMVVNPPYVPTPDEEVGSLGLSSAWAGGENGRNVIDKILPVADNLLSDKGWLYMLFLAENDPLQICLQMRDKGYGAKIVVQRSTEEETLHVIKFWRDPDIQMEGNEANLTPKTAPQRGLEFLLSHISRLSFRERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH70</accession>
    <name>A0A103YH70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001074">
        <property type="protein sequence ID" value="KVI09034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH70"/>
    <dbReference type="STRING" id="59895.A0A103YH70"/>
    <dbReference type="Gramene" id="KVI09034">
        <property type="protein sequence ID" value="KVI09034"/>
        <property type="gene ID" value="Ccrd_012598"/>
    </dbReference>
    <dbReference type="OMA" id="DMFGKCK"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003116">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF426">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY, DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="594"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="686" mass="76958" checksum="1000B1C8DD7346D3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ71</accession>
    <name>A0A103YJ71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ71"/>
    <dbReference type="STRING" id="59895.A0A103YJ71"/>
    <dbReference type="Gramene" id="KVI10058">
        <property type="protein sequence ID" value="KVI10058"/>
        <property type="gene ID" value="Ccrd_011504"/>
    </dbReference>
    <dbReference type="OMA" id="WHLISTH"/>
    <dbReference type="OrthoDB" id="1935281at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="257" mass="29297" checksum="4851EFC11D66B3BB" modified="2016-04-13" version="1">MFSSFEHSREVSFQIPSTTQQQQDHHNRLTSVTALRRLPTGPFDDHKLVPSQQKPGRKRSCNNLQQQDHHLVVDCDDENEKKKKRLEHREIERRRRQEMANLCSSLRSLLPLDFIKGRRSTSEHMNQVVNYIKHLEENIKGLETTRDELKKTCPHVTDSSSVLPNKNIENETSGRHGPNTVTVGCSHGGVEILIKSCTGFPISRVVKALVQEGLNVISCNSTKVNERFIHSIHSEVSDEICIQVSILQKKLVELVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJR5</accession>
    <name>A0A103YJR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calycin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001021">
        <property type="protein sequence ID" value="KVI10364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJR5"/>
    <dbReference type="STRING" id="59895.A0A103YJR5"/>
    <dbReference type="Gramene" id="KVI10364">
        <property type="protein sequence ID" value="KVI10364"/>
        <property type="gene ID" value="Ccrd_011231"/>
    </dbReference>
    <dbReference type="OMA" id="CTIERPA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031977">
        <property type="term" value="C:thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046322">
        <property type="term" value="P:negative regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010117">
        <property type="term" value="P:photoprotection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009644">
        <property type="term" value="P:response to high light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901562">
        <property type="term" value="P:response to paraquat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010431">
        <property type="term" value="P:seed maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF32">
        <property type="entry name" value="CHLOROPLASTIC LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="34268" checksum="D21D5CED9B54E665" modified="2016-04-13" version="1">MAYHHFTTATGKAPILLLPSHSPRKMPTNIRFKCSIELPLSISTTDAARHVVSGLAASLVLIVPTNQVLATQLSYNNLCQIASATNSMPTLPLDEGSNLMMMRGMTTRNFDPVRYSGRWYEVASLKRGFAGQDTFCVHGGPDGYITGIRGRVQCLPEEDVEKTETDLERQEMIKEKCYLRFPTLPFIPKEPYDVIDTDYDNFALVSGAKDRSFIQIYSRTPNPGPEFIAKYKLVLADYGYDPSKIKDTPQDCEVSDSRLAAMMSMNGMQQALTNQFPDLGLKSAVEFNPFTSVFDTLKKLVQLYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKJ0</accession>
    <name>A0A103YKJ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin alpha-6 chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000988">
        <property type="protein sequence ID" value="KVI10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKJ0"/>
    <dbReference type="STRING" id="59895.A0A103YKJ0"/>
    <dbReference type="Gramene" id="KVI10849">
        <property type="protein sequence ID" value="KVI10849"/>
        <property type="gene ID" value="Ccrd_010738"/>
    </dbReference>
    <dbReference type="OMA" id="KLCGYSP"/>
    <dbReference type="OrthoDB" id="2016911at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35699">
        <property type="entry name" value="F2J10.10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35699:SF1">
        <property type="entry name" value="F2J10.10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24168" checksum="BBAEE8002D465089" modified="2016-04-13" version="1">MASVKMLKAGLYPFSASPSSSRRNERFGCSGTRRIVKFSSKLSTNRVLKVSCRIQDADNSERNGEEPPESLFMKELKRRGMTPTSLLDESWTASNNKEMMFKDEDGNISSSNNVSTDFEKSLSNQRERSMALNSEGLEGLIPRANLLLRLGGTFFLAFWPLFLVTVASFSAIYLYFGPKFVHDGTARQVQLPQYIDPYALLEDERMSQTSPMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLA8</accession>
    <name>A0A103YLA8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="6 15">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_010410</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="6 15"/>
    <dbReference type="EMBL" id="LEKV01000819">
        <property type="protein sequence ID" value="KVI11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLA8"/>
    <dbReference type="STRING" id="59895.A0A103YLA8"/>
    <dbReference type="Gramene" id="KVI11184">
        <property type="protein sequence ID" value="KVI11184"/>
        <property type="gene ID" value="Ccrd_010410"/>
    </dbReference>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000004">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="43"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="43450" checksum="98704ACCA900629E" modified="2016-04-13" version="1">MAASMQLLNVTPFRFHSTSIPQHHSRPVIARCSATSSTAKSYNITLLPGDGIGPEVISVAKNVLNLAGSIEGIEFKFNEMPMGGAALDLTGVPLPEETLTAAKQSDAVLLGAIGGYKWDKNEKHLKPETGLLHLRQGLKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFGKPRGFGTDENGQKIGFNTEVYAEYEIDRIARIAFETARKRSGKLCSVDKANVLEASMLWRERVTAISAEYPDVELSHMYVDNAAMQLVRNPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGASGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEVKAAERIELAVLDTLNEGFRTGDIHSAGNKLVGCEEMGEQVLKSVDTKTPAASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMT2</accession>
    <name>A0A103YMT2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000020">
        <property type="protein sequence ID" value="KVI12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMT2"/>
    <dbReference type="STRING" id="59895.A0A103YMT2"/>
    <dbReference type="Gramene" id="KVI12019">
        <property type="protein sequence ID" value="KVI12019"/>
        <property type="gene ID" value="Ccrd_009570"/>
    </dbReference>
    <dbReference type="OMA" id="CHTLANF"/>
    <dbReference type="OrthoDB" id="1891924at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="419" mass="47577" checksum="B11956DBB39A324B" modified="2016-04-13" version="1">MEHLPVEVIGNILSRLGAARDVVIASATCRKWREAWRIHLHTLSFNSNDWPVYHELTTSRLEILITQTIFQTTGLQSLSIIMDDVDEFSAAPVIAWLMYTRESLRQLHYNVRTSPTINIIEKCGRQKLEVLNLSHNTISGVEPSYQRFPSLRSLSLSHISISALDLSYLLTACPKVEILTLLSLDIAMSDAQTSMELNSPSLKDLSVEAISLEKFILEADGLEKLQLKDCTLEVFELIGKGTLKLLKIDDVSVIHLDIGENTEHLEVVDVSNFTIMWAKFHHMISKASKLRGLRLWGVVFDDEDEVVDMETISICFPQLTHLSLCYDLKEAALQYSLQRSFELKNVIMLELGWTVITDLFSQWAAGLLERCPHLRKLIINGVVSEAKSHEECQVLASFTTSMVGLMRKYLHVDVQFEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNI9</accession>
    <name>A0A103YNI9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000003">
        <property type="protein sequence ID" value="KVI12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNI9"/>
    <dbReference type="STRING" id="59895.A0A103YNI9"/>
    <dbReference type="Gramene" id="KVI12401">
        <property type="protein sequence ID" value="KVI12401"/>
        <property type="gene ID" value="Ccrd_009168"/>
    </dbReference>
    <dbReference type="OMA" id="QCKIGQS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF102">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE JMJ31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="553" mass="62444" checksum="99EDA7579FCADE24" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118J4V8</accession>
    <name>A0A118J4V8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006738">
        <property type="protein sequence ID" value="KVH52976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118J4V8"/>
    <dbReference type="STRING" id="59895.A0A118J4V8"/>
    <dbReference type="Gramene" id="KVH52976">
        <property type="protein sequence ID" value="KVH52976"/>
        <property type="gene ID" value="Ccrd_025699"/>
    </dbReference>
    <dbReference type="OMA" id="RQMTHGS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF37">
        <property type="entry name" value="SIT4 PHOSPHATASE-ASSOCIATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH52976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="811" mass="90259" checksum="864ACE8139FD3699" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JF39</accession>
    <name>A0A118JF39_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006574">
        <property type="protein sequence ID" value="KVH69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JF39"/>
    <dbReference type="STRING" id="59895.A0A118JF39"/>
    <dbReference type="Gramene" id="KVH69087">
        <property type="protein sequence ID" value="KVH69087"/>
        <property type="gene ID" value="Ccrd_025610"/>
    </dbReference>
    <dbReference type="OMA" id="HGHEAGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="150"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="43368" checksum="EFA2B7363B2509E2" modified="2016-04-13" version="1">MRNGLSSSLSVTERGYLPSEKFDDDGRIKRTGTYMSATAHIITAVIGSGVLSLAWCFAQLGWIAGSITLVLFSVITMFNSILLTDCYRSPDPVTGTRNYTYMDAVKSNLGTLQYKLCGVAQYGVLTGITIGYTTTTAISMATGNGIGKTSLTGVPVGKDFSGMEKMWKTFSALGDVAFAYSFCFDTLKSSPPENKQMKKATATGIMASTVFYMLCGVLGYAAFGNDAPGNFLTGFGFYDPFWLIDIANICIVIHLLGAYQVLAQPLFGFVESSARKKWPQNKLVTKELSLCGIDINMFRLVWRTTYVIVTTIIAMIFPFFNDFVGLLGAGTFWPLSVYFPIEMYISQAKIPKYSFRWIWMQILSLACLIVSLVAAVGSTRGLITSVQSFKPFESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JIP3</accession>
    <name>A0A118JIP3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DESIGUAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006521">
        <property type="protein sequence ID" value="KVH74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JIP3"/>
    <dbReference type="STRING" id="59895.A0A118JIP3"/>
    <dbReference type="Gramene" id="KVH74767">
        <property type="protein sequence ID" value="KVH74767"/>
        <property type="gene ID" value="Ccrd_025567"/>
    </dbReference>
    <dbReference type="OMA" id="HAYMAQN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009606">
        <property type="entry name" value="DEAL/Modifying_wall_lignin1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052222">
        <property type="entry name" value="DESIGUAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31769">
        <property type="entry name" value="OS07G0462200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06749">
        <property type="entry name" value="DUF1218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="189" mass="20302" checksum="CFFCA53C9E1CB697" modified="2016-04-13" version="1">MSMNGQNMGQYVVPFVCLLIVIMDLTAGILGIQAEVQNLRVWIFECRDPSYQAFKLGFAAAVLLAFAHAIANLFGGCHCVWSKPELDRATSNKQLAMASLVLSWITLVIGFGMLIAGVMANSSSRKSCGVSNHRYLSIGGIACIIHGMFAVSYYISATAVEKEEKKLNPPGPMMNPPGPVHQTVPTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS46</accession>
    <name>A0A118JS46_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_025382</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01006288">
        <property type="protein sequence ID" value="KVH87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JS46"/>
    <dbReference type="Gramene" id="KVH87387">
        <property type="protein sequence ID" value="KVH87387"/>
        <property type="gene ID" value="Ccrd_025382"/>
    </dbReference>
    <dbReference type="OMA" id="HNGTGIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000053">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF417">
        <property type="entry name" value="LACCASE-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990253" description="Laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="131"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="424"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="565" mass="62719" checksum="F270092BAA6BA12D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS96</accession>
    <name>A0A118JS96_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005339">
        <property type="protein sequence ID" value="KVH88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS96"/>
    <dbReference type="STRING" id="59895.A0A118JS96"/>
    <dbReference type="Gramene" id="KVH88779">
        <property type="protein sequence ID" value="KVH88779"/>
        <property type="gene ID" value="Ccrd_025776"/>
    </dbReference>
    <dbReference type="OMA" id="NMATKCL"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000069">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050262">
        <property type="entry name" value="Ribose-5P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748:SF3">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="30475" checksum="E5C918DAF31581FC" modified="2016-04-13" version="1">MASLSLISSPPLSSSLLRRHHHHHNARLISFNSPRYLSIKAFSAPSPVQPLTQDDLKKLAADKAVEYVSSGMVLGLGTGSTAAFVVSKIGELLASGQLKDIVGVPTSKRTQEQAASLGIPLSILDDHPKLDLAIDGADEVDPDLNLVKGRGGALLREKMVEAASDKFVVVVDDSKLVSGLGGSGLAMPVEVVQFCWKYNLVRLQELFKEEGCDAKLRLDGDGKPYVTDNMNYIVDLYFKTPIKDAWSAGKEISSFEGVVEHGLFLDMTTAVIIAGKDGVSVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT58</accession>
    <name>A0A118JT58_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-processing protein, HAT helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT58"/>
    <dbReference type="STRING" id="59895.A0A118JT58"/>
    <dbReference type="Gramene" id="KVH90174">
        <property type="protein sequence ID" value="KVH90174"/>
        <property type="gene ID" value="Ccrd_007775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044624">
        <property type="entry name" value="Mbb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917:SF1">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="584" mass="65277" checksum="33EF7A139E6F44B2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUA8</accession>
    <name>A0A118JUA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APOBEC/CMP deaminase, zinc-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004840">
        <property type="protein sequence ID" value="KVH92169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUA8"/>
    <dbReference type="STRING" id="59895.A0A118JUA8"/>
    <dbReference type="Gramene" id="KVH92169">
        <property type="protein sequence ID" value="KVH92169"/>
        <property type="gene ID" value="Ccrd_005798"/>
    </dbReference>
    <dbReference type="OMA" id="EIIMSCH"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF199">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="186" mass="20210" checksum="F753E55B080F408C" modified="2016-04-13" version="1">MEEANIVETKDGTISVASAFAGHQEVVQDRDHKFLTRAVEEAYKGVDCGDGGPFGAVVVCKDEIVVSCHNMVLKHTDPTAHAEVTAIREACKKLNQIELSDCEIYASCEPCPMCFGAIHLSRIKRLVYGAKAEAAIAIGFDDFIADALRGTGFYQKANLEIKKADGNGAIIAEQVFENTKSKFSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUT0</accession>
    <name>A0A118JUT0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L30e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004894">
        <property type="protein sequence ID" value="KVH91987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUT0"/>
    <dbReference type="STRING" id="59895.A0A118JUT0"/>
    <dbReference type="Gramene" id="KVH91987">
        <property type="protein sequence ID" value="KVH91987"/>
        <property type="gene ID" value="Ccrd_005986"/>
    </dbReference>
    <dbReference type="OMA" id="LWRVHIG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="10811" checksum="7413083C0CFE3729" modified="2016-04-13" version="1">MVSGKKTKKTHESINNRLALVMKSGKYTLGKLIIISNNCPPLRKSEIEYYAMLAKVGVHHYNGNNVDLGTASGKYFRVSSLSIIDAGDSDIIKSLPGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW86</accession>
    <name>A0A118JW86_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSL (TC 2.A.67.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004394">
        <property type="protein sequence ID" value="KVH95274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW86"/>
    <dbReference type="STRING" id="59895.A0A118JW86"/>
    <dbReference type="Gramene" id="KVH95274">
        <property type="protein sequence ID" value="KVH95274"/>
        <property type="gene ID" value="Ccrd_002646"/>
    </dbReference>
    <dbReference type="OMA" id="ENWGWYI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051980">
        <property type="term" value="F:iron-nicotianamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF11">
        <property type="entry name" value="METAL-NICOTIANAMINE TRANSPORTER YSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="673" mass="74149" checksum="5C81979049652DBF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWZ1</accession>
    <name>A0A118JWZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWZ1"/>
    <dbReference type="STRING" id="59895.A0A118JWZ1"/>
    <dbReference type="Gramene" id="KVH95172">
        <property type="protein sequence ID" value="KVH95172"/>
        <property type="gene ID" value="Ccrd_002791"/>
    </dbReference>
    <dbReference type="OMA" id="IQFSTMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052636">
        <property type="term" value="F:arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052325">
        <property type="term" value="P:cell wall pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053250">
        <property type="entry name" value="Glycosyltransferase_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46936">
        <property type="entry name" value="ARABINOSYLTRANSFERASE XEG113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46936:SF1">
        <property type="entry name" value="ARABINOSYLTRANSFERASE XEG113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="69518" checksum="C65F76DE14DB0468" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXL4</accession>
    <name>A0A118JXL4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003852">
        <property type="protein sequence ID" value="KVH97151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JXL4"/>
    <dbReference type="Gramene" id="KVH97151">
        <property type="protein sequence ID" value="KVH97151"/>
        <property type="gene ID" value="Ccrd_000750"/>
    </dbReference>
    <dbReference type="OMA" id="DRMETHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000024">
        <property type="entry name" value="Eukaryotic translation initiation factor 4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="1583"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1551"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1374"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1376"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH97151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1746" mass="189526" checksum="33214F81B0EFBFA0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYZ9</accession>
    <name>A0A118JYZ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calmodulin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYZ9"/>
    <dbReference type="STRING" id="59895.A0A118JYZ9"/>
    <dbReference type="Gramene" id="KVH98877">
        <property type="protein sequence ID" value="KVH98877"/>
        <property type="gene ID" value="Ccrd_022871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF64">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="27987" checksum="84698EC986F72CD7" modified="2016-04-13" version="1">MDLEPGSLKLMFSTGVASPVFTGKKIRGEAGGGGDEYESIKVVLVESQTNQPFISRFPASIRVRIVLLPEEFGGSTTVDGGGVWTTSEFKNSVITNWENKKKILRGDPFVDLKNGSGSVGEIRIKHDKKHLSKCRFRLGAMVVVSSKRRPVSLNDNVSRLKNVGRKGVLRLESKNIMTCNVCGSVGSTSRHEDNPSFADHVDFTRLDAELYMPSPSSSSNDTITTLDPIPDIDDTENFFQYFMSKIFMEELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZS7</accession>
    <name>A0A118JZS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003419">
        <property type="protein sequence ID" value="KVH99699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZS7"/>
    <dbReference type="STRING" id="59895.A0A118JZS7"/>
    <dbReference type="Gramene" id="KVH99699">
        <property type="protein sequence ID" value="KVH99699"/>
        <property type="gene ID" value="Ccrd_022067"/>
    </dbReference>
    <dbReference type="OMA" id="VFLQFTW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010025">
        <property type="term" value="P:wax biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF259">
        <property type="entry name" value="PROTEIN ECERIFERUM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="397" mass="44572" checksum="733BC4775D2F0B32" modified="2016-04-13" version="1">MEAKLSNIRLSTVVPGQMTVENTVHHLTNTDLAMKHHYIKAVYFFNNEFAELGLIISDLKTAMSHLLSRYFTVAGRIRRRPEDNRPFIKCNDGGVRVVEAESNTSIDEWVEMKHSDVSELAYRDHVLGPDLQFSPLLFLQFTKFKCGGFSVGLNWSHVIGDAFSTSTFVNMWAQIVNCKTLSHISISTKLQISERPSTFQNIDLVGNHWFNVNNTKMVTFSLHISSKNLDQITSKANAKPFQALCATIWKSLAKIRAQLEPKTVTICTYGSQKNEIKSQGNNQRVSKVVVDFTVSEASVIDLAELITVKQNNSDAMFYGETLTFVNLEEAKLYGFELKGHKPVLANYAMTGVGDEGVALVLQGPENYRGRLLTMTLPSDQVVALKNELIKEWNIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K009</accession>
    <name>A0A118K009_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003359">
        <property type="protein sequence ID" value="KVI00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K009"/>
    <dbReference type="Gramene" id="KVI00678">
        <property type="protein sequence ID" value="KVI00678"/>
        <property type="gene ID" value="Ccrd_021075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="93" mass="10832" checksum="031CC95556470889" modified="2016-04-13" version="1">MVALLYFVEGMHVNIRWRGSGIGDLVYIQFRPEISSSQGTSIYRRKQRLNSKDCNKAFALRLGHYLASITHLKHVESDKEAILLKRENVEWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K117</accession>
    <name>A0A118K117_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002661">
        <property type="protein sequence ID" value="KVI02162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K117"/>
    <dbReference type="STRING" id="59895.A0A118K117"/>
    <dbReference type="Gramene" id="KVI02162">
        <property type="protein sequence ID" value="KVI02162"/>
        <property type="gene ID" value="Ccrd_019558"/>
    </dbReference>
    <dbReference type="OMA" id="DESMVCE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34546">
        <property type="entry name" value="OS06G0153600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34546:SF3">
        <property type="entry name" value="OS06G0153600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32212" checksum="184933015E5A7D00" modified="2016-04-13" version="1">MDPYYEQRLRDEVIYLHSLWHRGPLYRSLPYTTLQPYNSTNFKKHKKKSKSNARQSKKVGSFSGKEWPVKPLSADPPLTQSGWPELKLKPNPQQTPRLPTPEDLEKFKDCIALVQHSISIAKTKKLRSHRAYGQVVCKVLGWDIDRLPSSIVADYKGNGVNADKDVNNGGDNAGLNKNTDNGESNLQVDPNGSCHDVSEIVDDESMVCEGNDVNVDKDVNNDGDNEGLNKIIDNEESNLQVNPNGKGQDVTKTIDAESMVCEESVVNNGAGTTTTARQQQQCSCRLTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K149</accession>
    <name>A0A118K149_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002659">
        <property type="protein sequence ID" value="KVI02308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K149"/>
    <dbReference type="STRING" id="59895.A0A118K149"/>
    <dbReference type="Gramene" id="KVI02308">
        <property type="protein sequence ID" value="KVI02308"/>
        <property type="gene ID" value="Ccrd_019424"/>
    </dbReference>
    <dbReference type="OMA" id="VMFANRL"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF69">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15334" checksum="1FC8862F613C6618" modified="2016-04-13" version="1">MTPFLCMLVIAEMVVILILLFRTPLRKLVMVVMDRLKEGRGPVMSTVAATLFVFLMSTLYSIMKIQQRSMENGAVNPTDHVLLANHILDASLMGFCLFLGLMIDRLHYYVKRFDDSEGIKPVNKAKKTYETSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1B5</accession>
    <name>A0A118K1B5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002649">
        <property type="protein sequence ID" value="KVI02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1B5"/>
    <dbReference type="STRING" id="59895.A0A118K1B5"/>
    <dbReference type="Gramene" id="KVI02612">
        <property type="protein sequence ID" value="KVI02612"/>
        <property type="gene ID" value="Ccrd_019099"/>
    </dbReference>
    <dbReference type="OMA" id="RFGDMIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF191">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36048" checksum="E6887067B68B0D0A" modified="2016-04-13" version="1">MGTVTSSMAAKFAFFPPSPPSYRVVVDESSGGKTSRMTDVPERENVDVLKLKTKRGTEIVAVYVKNPMASLTVLYSHGNAADLGQMYELFCELSLHLRVNLMGYDYTGYGRSSGKPTEHNTYADVEAVYRCLLETYGAKEEDIILYGQSVGSGPTLDLASRLSRLRAGTADDVVDWSHGKELWELCVEKYEPLWVKGGNHCDLELYPEYIRHLKKFISAVEKSGRLKNLSGPLVDHGDKHRVSTDCRDKPRPSTDRPDHSRPSVDCRDKSRSSVDRREKSKKNAEQHVGKSTNAIDQPEKARNSIDRGRKIIMSVVSGGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2F7</accession>
    <name>A0A118K2F7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002258">
        <property type="protein sequence ID" value="KVI04273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2F7"/>
    <dbReference type="STRING" id="59895.A0A118K2F7"/>
    <dbReference type="Gramene" id="KVI04273">
        <property type="protein sequence ID" value="KVI04273"/>
        <property type="gene ID" value="Ccrd_017416"/>
    </dbReference>
    <dbReference type="OMA" id="GNRILCN"/>
    <dbReference type="OrthoDB" id="2013508at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36004">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36004:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="186" mass="20446" checksum="6054001669313704" modified="2016-04-13" version="1">MALNGGRILCNTSTITPYTRLPLHRPFSFTHPSSRTPFHLVSAAKKLSSRTGKFDSRNKRGSTSTTEDESSGEFNDGAIGTVDGTEVENFDGYVLPDLPGLEPDFWEGPQWDAFGFFVEYLWAFGIVFALVSSGIAVSTYNEGATDFKETPAYKESIQSRDLLEEPEASSPDVFESNPTEEAPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2T2</accession>
    <name>A0A118K2T2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_016814</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Plant hormone biosynthesis; brassinosteroid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001904">
        <property type="protein sequence ID" value="KVI04858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2T2"/>
    <dbReference type="STRING" id="59895.A0A118K2T2"/>
    <dbReference type="Gramene" id="KVI04858">
        <property type="protein sequence ID" value="KVI04858"/>
        <property type="gene ID" value="Ccrd_016814"/>
    </dbReference>
    <dbReference type="OMA" id="MIIHSTR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF44">
        <property type="entry name" value="3BETA,22ALPHA-DIHYDROXYSTEROID 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI04858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="461" mass="52844" checksum="BED8D1263C1A9234" modified="2016-04-13" version="1">MITMDDLFLSLLFTLSLSTIIFFLLRTTTASRRKGRMPPGSIGLPLIGETFQLISAYKTENPEPFIDARVSKYGTVFTTHVFGERTIFSADAETNRFILQNEGRLFESSYPGSISNLVGKHSLLLMRGSLHRRMHSLTMSFANSTIIKDHLLVDIDRLVRLNLDSWTGRILLMEEAKKITFELTLKQLLSIDPCEWTENLRKEYMLVIEGFFCIPLPFFSLTYRRAIQARKRVTEALNLVVRERRRERERGVKKNDMLAALFDSDGDDVIFCDDEIVDFLVSLLVAGYDTTSTTMTLAEEHDAIRAKKGTSVALEWDDYKSMPFTQCVVNETLRLSNIISGVFRRAMTDVTIKGYTIPKGSKVFTSLRAVHLGQDNFEDARVFDPWRWQKTSDPTNFMPFGGGPRRCPGYELAKVALSVFLHHLVTRFSWKPAEKDKLVFFPTTRTQKRYPIIMEHRNVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K329</accession>
    <name>A0A118K329_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding lysin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001881">
        <property type="protein sequence ID" value="KVI05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K329"/>
    <dbReference type="Gramene" id="KVI05253">
        <property type="protein sequence ID" value="KVI05253"/>
        <property type="gene ID" value="Ccrd_016413"/>
    </dbReference>
    <dbReference type="OMA" id="PIMSNEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF55">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="24371" checksum="CF64B03DF742D25A" modified="2016-04-13" version="1">MQTQRRNTRDNFWNHKLDRGLLMESSPPSKLVSNGSSSYSMQSSCDTSPGGGGSSVGDGGLGYIEHTVTKFDTLAGVAIKYGVEVADIKKMNGLTTDLQMFARKTLQIPLPGRHPPSPIMSNEYDSQGPKAANRTSDAEVGQNVAPLKLGDSLTIETSSGVKKSSSTPSFYDAYNSNNSSNCTTTSSIWPTSMLNLTADLQASTAAIARPIFDGLPKPMSGRKNKAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3J6</accession>
    <name>A0A118K3J6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3J6"/>
    <dbReference type="STRING" id="59895.A0A118K3J6"/>
    <dbReference type="Gramene" id="KVI06078">
        <property type="protein sequence ID" value="KVI06078"/>
        <property type="gene ID" value="Ccrd_015591"/>
    </dbReference>
    <dbReference type="OMA" id="IVHHEDL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF27">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159942" description="Concanavalin A-like lectin/glucanase, subgroup" evidence="5">
        <location>
            <begin position="30"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24109" checksum="E1F29AC713879410" modified="2016-04-13" version="1">MGMNLFLKNWMIPSWVLSCLLLVLVPMDAVRPDPPLSSIADPVLPTEKKPPFSRIPTEYEAHSPGVSEIIVHHEDLNKKILVALIIASTLLAGILVFLFCFWIFKQKNSEPLNAKQPPKCQDASKGLSLGPILDKFTPSRIAGRKGSVTVIDYEWLVSATNNFHEENIVRVETSGHLYKARFNDHFVAAVKRLHGRGPDAQRGFEVTYEHIPFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3U3</accession>
    <name>A0A118K3U3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3U3"/>
    <dbReference type="Gramene" id="KVI06480">
        <property type="protein sequence ID" value="KVI06480"/>
        <property type="gene ID" value="Ccrd_015180"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF202">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="372" mass="41124" checksum="44481B42DA3B2FF1" modified="2016-04-13" version="1">MAEVHCFDHDDEDDFLVSFSSRNNLHAYPSRISPFDRQNQVNFEIDMFRQSQSQSQSQSQSHCVSPVIQESPLVPFHRSFGVQEGNHDIDFDVEFGSRLGFFEGNHHNRNANANDSGFTVAGSGDDLFVSRRTSGLHGARSESGVSSYESGSPDFFLGGVRATDLVSDVDDIIPVNGNTNEDLQWDEVLDVNEDYEVLGVCLRADVGDGDDDDDDHGDDDDVLSGIPPGGEQFQEIQEAFEWQVLSNVHNFEPTPDLADDDYNYTEYEMFFGQFGDTGVSSLGRPPASKSVVANLSTVAVTQEDVENNTTLCAVCKDEVGVGEMATLLPCSHRYHGDCIGAWLGIRNTCPVCRHELPTDDVDYELRKTARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5G4</accession>
    <name>A0A118K5G4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001073">
        <property type="protein sequence ID" value="KVI09058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5G4"/>
    <dbReference type="Gramene" id="KVI09058">
        <property type="protein sequence ID" value="KVI09058"/>
        <property type="gene ID" value="Ccrd_012568"/>
    </dbReference>
    <dbReference type="OMA" id="MYTNCGI"/>
    <dbReference type="OrthoDB" id="1902039at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF544">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="771"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="806"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="955" mass="107211" checksum="D3EA7EC42AE157E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5R1</accession>
    <name>A0A118K5R1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001058">
        <property type="protein sequence ID" value="KVI09497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5R1"/>
    <dbReference type="STRING" id="59895.A0A118K5R1"/>
    <dbReference type="Gramene" id="KVI09497">
        <property type="protein sequence ID" value="KVI09497"/>
        <property type="gene ID" value="Ccrd_012107"/>
    </dbReference>
    <dbReference type="OMA" id="DKCWQWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374">
        <property type="entry name" value="AUXIN-INDUCED PROTEIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374:SF9">
        <property type="entry name" value="AUXIN-RESPONSIVE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17432" checksum="B3DE759E2F3FE821" modified="2016-04-13" version="1">MFPTTDKKRGDGFENPEPLHHIGPHPLLPPPATSLSASSLTMCPTTDCDKCWQWAFRWPSSFKHERKEEACIPKDVPKGHLVVYVGDNQRRFVIKVKLLKHPLFSALLDETREEYAFTADSRLHITCDEDIFLGVVRCAMTSRDRRTMWCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6P7</accession>
    <name>A0A118K6P7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000967">
        <property type="protein sequence ID" value="KVI10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6P7"/>
    <dbReference type="Gramene" id="KVI10993">
        <property type="protein sequence ID" value="KVI10993"/>
        <property type="gene ID" value="Ccrd_010606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="7916" checksum="1281B0C03FD80710" modified="2016-04-13" version="1">MDVEEGERERERAQRETAPLMEEPSRVELPWSTKTRKMCFTSFSRTLAMGVERGERAQRKTGVRVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6S9</accession>
    <name>A0A118K6S9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000876">
        <property type="protein sequence ID" value="KVI11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6S9"/>
    <dbReference type="STRING" id="59895.A0A118K6S9"/>
    <dbReference type="Gramene" id="KVI11161">
        <property type="protein sequence ID" value="KVI11161"/>
        <property type="gene ID" value="Ccrd_010433"/>
    </dbReference>
    <dbReference type="OMA" id="FLDPRCD"/>
    <dbReference type="OrthoDB" id="1736072at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35490:SF3">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35490">
        <property type="entry name" value="BACTERIOPHAGE N4 ADSORPTION B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="43171" checksum="0A80AE534FBE3AFA" modified="2016-04-13" version="1">MPTFTTIALENLLEHRNSGKNSSTLKNPQPSTNENDEATEEKRAKTSKRLNHIYISPALYTTPEPTPILDYSSSGSLSSSPYVFNRKGRGGGKSANRRVDGFEVEGNGSQSVGNGGEVLQGGEEELVESSLFGGGENENGNFMVVEDEGECADDDDDDDDGEFVDPRCDSFSVGSSSELNDSGRIASMSVLTNQIGEFYDAIEDFSSDGSMLSVASCSRNIESELCATKLSLLEEIEKRKTAENNVAMMCSRIQRMGKLLVCSENDSSWFDINAMEQLCQQVIVGRYVAEAVGKAEAQVEAEVAAEVIIGSKDKEISRLRDRLQYYEAMIHEMSQKNVESMEVARRQRERKRGERKWLWSCVGMSIVIGASIIAYSYAPLPHVEAEAEATGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6U5</accession>
    <name>A0A118K6U5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000781">
        <property type="protein sequence ID" value="KVI11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6U5"/>
    <dbReference type="Gramene" id="KVI11220">
        <property type="protein sequence ID" value="KVI11220"/>
        <property type="gene ID" value="Ccrd_010372"/>
    </dbReference>
    <dbReference type="OMA" id="PRFWKTF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48196">
        <property type="entry name" value="DUF630 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48196:SF1">
        <property type="entry name" value="DUF630 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="14258" checksum="3D75B348DD4123C8" modified="2016-04-13" version="1">MGTKAMEEVEVVMKRFGDEQSTLLDRFERLSFEVKLNEAILGRSLSEPRYQVPALPLQLPRPLESKVTDQGHRHHRRLGFQKVWKKLFKPIFGSRKEGGKESIPDEKINFKFMKAFSRSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K769</accession>
    <name>A0A118K769_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000046">
        <property type="protein sequence ID" value="KVI11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K769"/>
    <dbReference type="STRING" id="59895.A0A118K769"/>
    <dbReference type="Gramene" id="KVI11733">
        <property type="protein sequence ID" value="KVI11733"/>
        <property type="gene ID" value="Ccrd_009849"/>
    </dbReference>
    <dbReference type="OMA" id="HPNEDMR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1308" evidence="1">
        <location>
            <begin position="293"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="461" mass="50844" checksum="D3C041EFBE57B66D" modified="2016-04-13" version="1">MDVYQERDNFGTLGATVEEAKKRCEAVMDAVEALHLSLSCKRTLLRLIQSELSFLSRFSSTDFTPNSEPSICVNIGHLEAVVHILKHPNISGVPRVCKTILVPPSTQSGIHSTTSKGAHVDIVCTFDGSPVWFIVSDRNPKYVSWYGQQESSKKKGLRARVQLLLEVAHYSVTLKPTSLIFFFSNGLDGFTRQKFHSEFGAIDLGSKFSNFDFNFSEELGGEWIDILARSYHHASVLEIKVDSPRDVNPHVPKESLVAYSSVKASDVNLGGSFNTLLSQMISPYNGKLDGILINFDTTALIAIVSGISNGNTEKLLATPEDELKTRFKGNYEFVIGQVMSEIRNPIHMDIAKSISGRKAIICESVSSEFKELVSMCGGSNEKLRAGELLKHVVVVPDSPSTRMTSLPTTRKLAMKNKIVFGTGDHWHAPTLTANMGFVRAVLQTGMSLFTFEHRPRALTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RJ06</accession>
    <name>A0A124RJ06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007392">
        <property type="protein sequence ID" value="KVG93225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RJ06"/>
    <dbReference type="STRING" id="59895.A0A124RJ06"/>
    <dbReference type="OMA" id="FEPANWM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVG93225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="220" mass="24664" checksum="A07D437E37105741" modified="2016-04-13" version="1" fragment="single">LVIYLLKCERSNVSNRSKYCQAIYDICLRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPIIHFMLSSYAPVISAEKAYHEQLSVADITNSAFEPSSMMAKCDPRHGKYMACCLMYHGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RY30</accession>
    <name>A0A124RY30_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006791">
        <property type="protein sequence ID" value="KVH48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RY30"/>
    <dbReference type="STRING" id="59895.A0A124RY30"/>
    <dbReference type="Gramene" id="KVH48447">
        <property type="protein sequence ID" value="KVH48447"/>
        <property type="gene ID" value="Ccrd_025723"/>
    </dbReference>
    <dbReference type="OMA" id="WFAMEDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF20">
        <property type="entry name" value="BROMODOMAIN ASSOCIATED DOMAIN, HISTONE-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="439" mass="47864" checksum="899936DAB3AB9214" modified="2016-04-13" version="1">MTIDSFQSETRVIFLPNRGFAGTHLISSDFTQSIPSLFMLLEISFRSVPVAETLTYAYYCDGEGGGSSRGNGSGLKKRRKNEEFARSLARVAVAQICEGVGLQGFQQSAIETLSDITCKYIQDIGRTSNFCANLAGRTESNVFDIVRGLEDLGLSQGFVGASDIGHCLSGSGIIKDISQYVGASEEVGFAYSVPPFPVIRERQSIPSFFHAGETPPVDNIPPWLPCFPDPTTYAIPATVDIEQTERRQDGVDQDHMVIGPLLLKSEQCLACNGSQVAVVVEVGRNGVREQVNNPFLASPLQSGEKEVSLVSLPARLVEEEVAQNHSLWANHASALGTFAPGIQGLKSNGLDIEEGSKKVVLERRHAVQLKFHVGKKSLTAANRQGRIGNAEAMSWFANDDLRDDKRKEKKENSEGVNGKWEAYEIDRVPAKDKEKGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAQ4</accession>
    <name>A0A124SAQ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Peroxidase</fullName>
            <ecNumber evidence="3 19">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_024377</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16 19">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="16 19">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="3 19"/>
    <dbReference type="EMBL" id="LEKV01005501">
        <property type="protein sequence ID" value="KVH88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAQ4"/>
    <dbReference type="STRING" id="59895.A0A124SAQ4"/>
    <dbReference type="Gramene" id="KVH88227">
        <property type="protein sequence ID" value="KVH88227"/>
        <property type="gene ID" value="Ccrd_024377"/>
    </dbReference>
    <dbReference type="OMA" id="RYSGAIR"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000010">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31235">
        <property type="entry name" value="PEROXIDASE 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 19" id="KW-0349">Heme</keyword>
    <keyword evidence="13 19" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="11 16 19" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 19 21" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990595" description="Peroxidase" evidence="19">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="20">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="122"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="329" mass="35419" checksum="BD266284FF8A194F" modified="2016-04-13" version="1">MEVFSHFHSKTPIFFVVLLATFITLSLGQGTRVGFYRTTCPRAETIVQAAVQSAIRSNPTIAPGLLRMSFHDCFVNGCDASILIDGPSTEKTAGPNSLLRGFEVIDAAKTQLEAICPGVVSCADILALAARDSVVQAGGTGWAVPTGRRDGLVSRAADTANLPAFNDPINVQIRKFTDKGLNTQDLVALSGAHTIGTAACALFSYRLYNFNNTNGPDPSINQAFLPQLRNLCPNGGDGSRRVALDTGSVNNFDNSYYANLRAGRGVLESDAVLWNDPTTQRFVQRFLGLRGLLGLRFNVEFGRSMVKMGNIELKTGTQGEIRRVCNAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAQ7</accession>
    <name>A0A124SAQ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005502">
        <property type="protein sequence ID" value="KVH88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAQ7"/>
    <dbReference type="Gramene" id="KVH88225">
        <property type="protein sequence ID" value="KVH88225"/>
        <property type="gene ID" value="Ccrd_024379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="13813" checksum="947444C719194E23" modified="2016-04-13" version="1" fragment="single">MSSGPQVSSMIVGVSNEDLHVIVDEGGSNEGENVSMEVNEEPCEPPLNTTNKEAETDNNPFHNSKRPRRSKVWDEFFDPEMIKNQWKVRDESVECEFGSNTREGNDGSSGLFELLLDVFSGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB38</accession>
    <name>A0A124SB38_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB38"/>
    <dbReference type="STRING" id="59895.A0A124SB38"/>
    <dbReference type="Gramene" id="KVH89440">
        <property type="protein sequence ID" value="KVH89440"/>
        <property type="gene ID" value="Ccrd_008585"/>
    </dbReference>
    <dbReference type="OMA" id="HECCKEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="169"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="327" mass="37137" checksum="9865E559B81CB719" modified="2016-04-13" version="1">MASSSKPLPRCHESLKELAKELKMEVPHRYVQEQREPTFVSSGSLPLPSIPVIDMNDLIKIVLGSDDAVDELNKLRSVCHEWGIFQLVNHGVDKLLVEKMKEAMVEFFQIPEEEKLRYKLKEGEYEGYGQTILHDQDQKLQRLAMTLFHLIGQAVDIDKQEMSDVFEDGMQSVRMTYYPPCPKPDLVIGLTPHSDAAGITILLQVNDIEGLQVKKDGIWIPVNFLPNAFVVNVGDVLEIMSNGAYNSIEHRATVHATKERISLAMFFNPKFQADVGPAKSLLKNTRNPPLYKTLVMEQYLKEFFSGKLNGKTFLKKMKIENEEACET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBX5</accession>
    <name>A0A124SBX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004885">
        <property type="protein sequence ID" value="KVH92006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBX5"/>
    <dbReference type="STRING" id="59895.A0A124SBX5"/>
    <dbReference type="Gramene" id="KVH92006">
        <property type="protein sequence ID" value="KVH92006"/>
        <property type="gene ID" value="Ccrd_005967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="152" mass="17318" checksum="D1EDAF80D5E49FDC" modified="2016-04-13" version="1">MYDLPRKFTYGVIESYEQGRMNNEEEASLESGNQHVAEWHSFSDLNNPERSDAYVTRVLDPEQADLFYVQFFSSLSLVANVVRDGPDDPNALHKIVDRVKTAVLLVSDFGRLGRNQGSTVKDVILPYSHRINPYKGDIGVEKRKSLMFFMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDA3</accession>
    <name>A0A124SDA3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004330">
        <property type="protein sequence ID" value="KVH96340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SDA3"/>
    <dbReference type="Gramene" id="KVH96340">
        <property type="protein sequence ID" value="KVH96340"/>
        <property type="gene ID" value="Ccrd_001575"/>
    </dbReference>
    <dbReference type="OMA" id="LAAXDVS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7458" checksum="15038F4542D91B9F" modified="2016-04-13" version="1" fragment="single">MLAAXDVSQRCKELGINALHIKLXATGGNKTKTPGPGAQSALRALAWSGMKIGRIGISFFTFFFLKQVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFA8</accession>
    <name>A0A124SFA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the C-terminally encoded plant signaling peptide (CEP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002646">
        <property type="protein sequence ID" value="KVI02672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFA8"/>
    <dbReference type="Gramene" id="KVI02672">
        <property type="protein sequence ID" value="KVI02672"/>
        <property type="gene ID" value="Ccrd_019039"/>
    </dbReference>
    <dbReference type="OMA" id="GIACHAI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902025">
        <property type="term" value="P:nitrate import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901371">
        <property type="term" value="P:regulation of leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033250">
        <property type="entry name" value="CEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348:SF3">
        <property type="entry name" value="PRECURSOR OF CEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348">
        <property type="entry name" value="PRECURSOR OF CEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="22670" checksum="B053CB13636386F1" modified="2016-04-13" version="1">MAHTPPNPSKTTIESWLQPPPPTRGAEDFRPTAPGHSPGVSFTAKKSGRTPSGIGGIACHAILLAEGRQLKPLKNKDKKDTETQTKHALDPLQKHLRNENSFQVSSAGEVPTITSPPVTEKEAKFPPQVPTQTQGDGISDLKAITAFRPTTPGNSPGAGHSFTEHRLDFESEASSNVNGIPQSNAESGNGFRPTKPGSSPGAGHSIHSKTTKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH19</accession>
    <name>A0A124SH19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001227">
        <property type="protein sequence ID" value="KVI08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH19"/>
    <dbReference type="Gramene" id="KVI08161">
        <property type="protein sequence ID" value="KVI08161"/>
        <property type="gene ID" value="Ccrd_013472"/>
    </dbReference>
    <dbReference type="OMA" id="VDNDEAW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250:SF18">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="277" mass="30844" checksum="5EA3573A4C220E6B" modified="2016-04-13" version="1" fragment="single">MADRRNWNIQEEDVLISILQEIVAAGGRSDNGCFRTGTYEQIVLKMREKIPGLNITSKHIQNKMKRLKDKYSAAYDMLNTSGFGWDDAHQCVTVDAQVLEEYLKLKKHPSKNYIANKPFPQYERLKTIFRKDRATGSMAESAADALEHINLESAVGDDTDELNVPLTTPSNGASASSIPQDVEASSKKRKRKAGVSEDAMKVIEKGLNVISEEMGKLVSVVGTPGLQTMPDELTNMGFDDDQVIAISMYFADNPIQLRLWNSMNATLKPKFVATILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHN6</accession>
    <name>A0A124SHN6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_011451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a SCF (SKP1-cullin-F-box) protein ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHN6"/>
    <dbReference type="STRING" id="59895.A0A124SHN6"/>
    <dbReference type="Gramene" id="KVI10111">
        <property type="protein sequence ID" value="KVI10111"/>
        <property type="gene ID" value="Ccrd_011451"/>
    </dbReference>
    <dbReference type="OMA" id="VMKSFIW"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009867">
        <property type="term" value="P:jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000022">
        <property type="entry name" value="SKP1-like protein 21 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176254" evidence="9">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="11">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="10">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="40156" checksum="4AE323158E0CFEF0" modified="2016-04-13" version="1" fragment="single">HKVRWFLGFLFLLASRLSRGARYGNLSSPVTSILKSKVRSDPHNSALLGSMAVMKPEMKSFIWLETPDGSTQQVEEEVAMFCPMICREVLQTGMGSSKNYAIKLPQRVNPSVLGLILDYCRFHQVPGRSNKERKTFDEKFIRLDTKKLCELTSGADSLQLRPLVDLTSRALARMIEGKTPEEIRDTFHLPDDLTEEEKLEPLRNRTDDPRIRLLNRLYARKRKELKVRETSKNVEIEEERVDDRSVDDLLLFINSGDEDSKGVKSVKNKKKNRRRKDHSKDSSLNIQNGCHKKETDSLSSSHNSEIEDVPSPSKISKEVEDFARRLNSVWPERVPGIISSGQDRRIAPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5H0</accession>
    <name>A0A103D5H0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011610">
        <property type="protein sequence ID" value="KVD98171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5H0"/>
    <dbReference type="STRING" id="59895.A0A103D5H0"/>
    <dbReference type="Gramene" id="KVD98171">
        <property type="protein sequence ID" value="KVD98171"/>
        <property type="gene ID" value="Ccrd_024131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVD98171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10193" checksum="DA51DB395B9C4615" modified="2016-04-13" version="1">MTATVDSRLLEIENLLLTADHRSVKLADFSLAREETLTGMMTANKNTATVCISSLRISHRLFSELFRDCLETVLGYLTAGLFVDGVASQLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103QPT1</accession>
    <name>A0A103QPT1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007996">
        <property type="protein sequence ID" value="KVG53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVG53372">
        <property type="protein sequence ID" value="KVG53372"/>
        <property type="gene ID" value="Ccrd_026367"/>
    </dbReference>
    <dbReference type="OMA" id="CREANEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007117298" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVG53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="39810" checksum="D0CC2EEA92A8B89C" modified="2016-04-13" version="1">MKTLVLMWVLLQMLISFTASETYTLINSTNLAKPGCPSRCGDVIVPYPFGIGIKSHCSIGPGFDVYCNTSLDPPKASFRRASYTSIKLISDSTLRTSNLVATRCYLPNGTFLDGVRMSSNLTNGSYTFSEVNKFTVIGCNDYAWLTSGTKSRNIYTGCMAFCSTLEDVXDQCSGNGCCQSSIPKDINYYRTRVKPMSSDNMSNTRTLNPCTHAFVGEENTFKFHGARDLKDTSLDKKIEANVPIVLEWAIGNMSCIDAKALNGFACQSNSKCVNSTRESRGYRCICNEGYEGNPYLSPGCQDINECKDKXRFPCYGTCVNDGGNYKCKCKQGYSGDAKIQGGCRRNIPILQLSLGNFYFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBT7</accession>
    <name>A0A103XBT7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Armadillo-like helical</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005773">
        <property type="protein sequence ID" value="KVH87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBT7"/>
    <dbReference type="STRING" id="59895.A0A103XBT7"/>
    <dbReference type="Gramene" id="KVH87843">
        <property type="protein sequence ID" value="KVH87843"/>
        <property type="gene ID" value="Ccrd_024844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF50">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44939" checksum="5DBD782BC384D174" modified="2016-04-13" version="1">MAQHSVSAFESHAEEITRYIVENIFLVKEGVMLDDLVSSHDTSEGSTCKLKIFGLKALVKSFLPHQCADVTRQIDEVLGIISQMLQRTKVSKGTLSRETDLEHLRFAAATSVLRLSQMWDPHISPHIYRLTVLTAKDHSSMVRQLFLEKTFKLLKNNVIHCKYLCAFALAASDSSGDLQNDDSLNYMSEIIRIHHRQAKVPRTSAVKRDAADDPVCTVIFLIHILAHDTEFPSQDSEYEEKSGSFFSPLVFTLQALLNPCYVDGDMNRICTVVSKLYNIFKAIKRTEDALDVQKTSRLHVLANFGAKYLVETKMSGTMVPQTTTSVLLPSLLYRKNCAKGGRESVEDPSALDGQLHKRSKSLNAHKRKLHETEEQIISGERENQDFASPESVTFHIDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC27</accession>
    <name>A0A103XC27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005668">
        <property type="protein sequence ID" value="KVH87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC27"/>
    <dbReference type="STRING" id="59895.A0A103XC27"/>
    <dbReference type="Gramene" id="KVH87964">
        <property type="protein sequence ID" value="KVH87964"/>
        <property type="gene ID" value="Ccrd_024654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="208"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="515"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="690" mass="76673" checksum="E3DC0FD3BE4B3EE2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEM8</accession>
    <name>A0A103XEM8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005239">
        <property type="protein sequence ID" value="KVH89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEM8"/>
    <dbReference type="Gramene" id="KVH89344">
        <property type="protein sequence ID" value="KVH89344"/>
        <property type="gene ID" value="Ccrd_008670"/>
    </dbReference>
    <dbReference type="OMA" id="CFNGPTM"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48152">
        <property type="entry name" value="F1C9.34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48152:SF9">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118727" description="Vacuolar protein sorting-associated protein 62" evidence="2">
        <location>
            <begin position="25"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61228" checksum="13C1A920F32186E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFF2</accession>
    <name>A0A103XFF2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005162">
        <property type="protein sequence ID" value="KVH89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFF2"/>
    <dbReference type="STRING" id="59895.A0A103XFF2"/>
    <dbReference type="Gramene" id="KVH89703">
        <property type="protein sequence ID" value="KVH89703"/>
        <property type="gene ID" value="Ccrd_008303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70330" checksum="F4B7D1A3BEF4B7D6" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFL0</accession>
    <name>A0A103XFL0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acyl-CoA oxidase</fullName>
            <ecNumber evidence="4">1.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_008228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.6" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005140">
        <property type="protein sequence ID" value="KVH89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XFL0"/>
    <dbReference type="Gramene" id="KVH89778">
        <property type="protein sequence ID" value="KVH89778"/>
        <property type="gene ID" value="Ccrd_008228"/>
    </dbReference>
    <dbReference type="OMA" id="RYLIKCC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000075">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="13">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="13">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="11">
        <location>
            <begin position="491"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="12">
        <location>
            <begin position="713"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="13">
        <location>
            <begin position="957"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH89778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1316" mass="147757" checksum="0C48E920597FA73B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG73</accession>
    <name>A0A103XG73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat stress transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_007807</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG73"/>
    <dbReference type="STRING" id="59895.A0A103XG73"/>
    <dbReference type="Gramene" id="KVH90184">
        <property type="protein sequence ID" value="KVH90184"/>
        <property type="gene ID" value="Ccrd_007807"/>
    </dbReference>
    <dbReference type="OMA" id="IPTEDCV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000057">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="14">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="49890" checksum="F2CF104408A05C9B" modified="2016-04-13" version="1" fragment="single">MESGSSNNGAAAAADGGGGGLLSNSPAPMPTVNAPPPFLVKTYDMVDDPSTDMIVSWSATNNSFIVRDPPEFARDLLPKYFKHNNFSSFVRQLNTYGFRKVDPDRWEFANEGFLRGQKHLLKSIVRRKPASGHNQQLQQPPGQSPSAGACVEVGKFGLEEEVERLKRDKNVLMQELVRLRQQQQSTDNQMQSMVQRLQGMEQRQQQMMSFLAKAVNSPGFLAQFVQQQSESTKLITEGSKKRRLKQDRVVPNGHSSSSDSSDGQIVKYQPMMNDSAKAMLRQIIKLDIVSPPSEILNNSSNVPSGGHNGSGVTIQEVLPPTSGQFYLPAVTGVQAAPLEANSDVVTTKQFPDTSSLADGQELPDISVLSNLQDMVADSYMHPETENGKFPLEIGNLSPGGDVEWDSNLLIEIEKYFAANDPSWEQFLEPNPEVEMECGPMDEHMMQQQQEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGQ6</accession>
    <name>A0A103XGQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005104">
        <property type="protein sequence ID" value="KVH90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGQ6"/>
    <dbReference type="Gramene" id="KVH90379">
        <property type="protein sequence ID" value="KVH90379"/>
        <property type="gene ID" value="Ccrd_007622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="66" mass="7939" checksum="58ACFC0714E6B19B" modified="2016-04-13" version="1">MENDDHDTKTERIHVLKNQIKEVKCRLEENKNDVPKERIEATKNLSEKYKQLRDEYNLLLGQKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIG0</accession>
    <name>A0A103XIG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family Cys-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005067">
        <property type="protein sequence ID" value="KVH91223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIG0"/>
    <dbReference type="STRING" id="59895.A0A103XIG0"/>
    <dbReference type="Gramene" id="KVH91223">
        <property type="protein sequence ID" value="KVH91223"/>
        <property type="gene ID" value="Ccrd_006754"/>
    </dbReference>
    <dbReference type="OMA" id="QPIDVQK"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="27295" checksum="4B134F96B9257BC1" modified="2016-04-13" version="1">MGEKSYVKLTREQEASLQDVTPGELNQPIDIHELHARRCPECGQSLPASYESPADEDWSTGIFSCADDPDSCMTGLFCPCVLFGRNIENLNDEIPSNNACMCHVLCVEGGMALATIIAFVPGIDPSTSCLITEGLFFAWWMCGIYTGMARQSLQRKYHLKDSPCDPCGVHCCLHWCAICQEHREMKMHLAANVEDTLVSPPRIQEMKAIEQNKTNAESTSSSSSYSSSPQRNSEDDTSMELQVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIJ5</accession>
    <name>A0A103XIJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005052">
        <property type="protein sequence ID" value="KVH91307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH91307">
        <property type="protein sequence ID" value="KVH91307"/>
        <property type="gene ID" value="Ccrd_006673"/>
    </dbReference>
    <dbReference type="OMA" id="LKSFCDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="296" mass="32921" checksum="DFAE94ADD3FE219E" modified="2016-04-13" version="1" fragment="single">MIKGLCKFGNYDTAIALLKMMNERGCKPTVVTYNTIIDGLCKDQXIDDALKLFKEMIVHKGILPDVVTYNPLIGGLRNLGHWDDGSKMLKEMEVDERISPDVVTFNILVDAFCKEGKVEDAEVLMNVMVEIGKDPNXVTYNSLIDGYCLRGEMTKAREAFDSMSIRGLVPNIVTCNSLLNGYCKEMKIDEALHLFHEITENGLVGEAKDLFLRMNERGCPPNSATYNVLIRGLLKNKQHDSIEMLLQEMDGHGFSLAASTLAMLLANTTARPFDAHLLKLIGKLVPKEGMDASCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIK6</accession>
    <name>A0A103XIK6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005053">
        <property type="protein sequence ID" value="KVH91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIK6"/>
    <dbReference type="Gramene" id="KVH91298">
        <property type="protein sequence ID" value="KVH91298"/>
        <property type="gene ID" value="Ccrd_006680"/>
    </dbReference>
    <dbReference type="OMA" id="IELCHEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613:SF207">
        <property type="entry name" value="OS08G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="11537" checksum="5B73692511A7E2FA" modified="2016-04-13" version="1">MDKRGFKAIVVTYNTIIDSLCKDMMVDDALKLFKEMIFDKGILLDVVAYTSLIRGLCSLGRWDDVSKMLKEMEDERISPNVVTFSIYISRCICKEGKVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIU5</accession>
    <name>A0A103XIU5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_006614</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: CAPH, CAPD2 and CAPG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005043">
        <property type="protein sequence ID" value="KVH91364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIU5"/>
    <dbReference type="STRING" id="59895.A0A103XIU5"/>
    <dbReference type="Gramene" id="KVH91364">
        <property type="protein sequence ID" value="KVH91364"/>
        <property type="gene ID" value="Ccrd_006614"/>
    </dbReference>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="16">
        <location>
            <begin position="518"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="317"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="754"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH91364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134573" checksum="FFE84B6B2A747F1B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJP6</accession>
    <name>A0A103XJP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004873">
        <property type="protein sequence ID" value="KVH92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJP6"/>
    <dbReference type="Gramene" id="KVH92030">
        <property type="protein sequence ID" value="KVH92030"/>
        <property type="gene ID" value="Ccrd_005940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32786" checksum="023428B75422F280" modified="2016-04-13" version="1" fragment="single">MTGISYQNIKLVRISQLKQQPNRRFQEFVGLLLLVADFDSQLKEAIIQASKWEPAGKENVLADYIAHAKSCDACQRKIPISSQSSQVRRWFLLGAICSEEYEVLSETSLSAASCYDGFQQLVCHYTVTQRNHVQISKEKICSGNKNNDIIQSQKGSLDKFVIKDGPSSLDNEHIDIDLDDACVDVNENPNMVNLVGTLNDSHEDLATNVDTNNASNDVPNVISNNASNDVLMERTTDGFLPYFEYTIHMKLWLIISLVNPLLIVIWYQSYRSGVLDLYAELDENDDKQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKQ4</accession>
    <name>A0A103XKQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004813">
        <property type="protein sequence ID" value="KVH92552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKQ4"/>
    <dbReference type="STRING" id="59895.A0A103XKQ4"/>
    <dbReference type="Gramene" id="KVH92552">
        <property type="protein sequence ID" value="KVH92552"/>
        <property type="gene ID" value="Ccrd_005411"/>
    </dbReference>
    <dbReference type="OMA" id="FNKVTRH"/>
    <dbReference type="OrthoDB" id="690722at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056116">
        <property type="entry name" value="DUF7699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35323">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35323:SF2">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24766">
        <property type="entry name" value="DUF7699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7699" evidence="3">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="44482" checksum="470BEA4A34BBCFEF" modified="2016-04-13" version="1">MKPPVIYISSSSDDDDDDDEGNFDDEEELESDFSPTDDGDDSESDDQDYDVEEENDSKSDEEDCFDNRDEISNRVVSFHQGSNDVKEPSLDECKAYLRKHGLRLSGTKEECIQRIKEHGRLKEGRCESLYPRSSFSINCTGDACKGDVVLFTQKVYNKFDKASRRGDVVGKRTVAGKIVKESYGASKQQHTFTIEVLWSKGPKKLPPLTPLLVKGRNLYRFRTLRQPWKSEAARSKVLGEKHKRGEAARHKRKLKKTQIAFENEEGRKRQKVSDRRPSTRTDKYESGQKRVNERNAVRFQKRESKTSQTTFGADPNRCVYSDHHHHHLQQASSSSIPNHPISNLPPLGFPGYHGHYYNGEPLLRNHVLYRPMGYNYEQPFPRYRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM08</accession>
    <name>A0A103XM08_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004790">
        <property type="protein sequence ID" value="KVH93230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM08"/>
    <dbReference type="Gramene" id="KVH93230">
        <property type="protein sequence ID" value="KVH93230"/>
        <property type="gene ID" value="Ccrd_004719"/>
    </dbReference>
    <dbReference type="OMA" id="FPFFAYQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000005">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118905" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="364"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="45625" checksum="41EF75AC1A368F5F" modified="2016-04-13" version="1">MAPPASYVQNLIFVILCSFLLQFFSFASSQSFIGVNYGIVADNLPAPEATAKLLQSTSIGKVRMYGADPAIIRALANTGIGIVIGAANGDIPALASDPNFATQWVNSNVLAYPDSKIIVITVGNEVMSSVDQSLVSLCLPAMQNVQNALNAVLASSDPPSSAVFNSGFSDTMRSLLKFHSANGSPFMINPYPFFAYESDPRPETLAFCLFQPNSGRVDSATGIKYLNMFDAQVDAVRSALNAMGFKDTEIVVAETGWAYKGDPNEIGPSVDNAKAYNGNLINHLRSKVGTPLMPGKSIDTYIFALYDENLKPGPGSERAFGLFKPDLSMTYDAGLSKNSQTPTTPTSPATPTTPATPSPVQAAGWCVPKPGVSDAQLQSNLDYVCGQGLDCGPIQPGGACFDPNTIASHAAYAMNLLYQTAGYNGCIYPGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMF7</accession>
    <name>A0A103XMF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_004783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004792">
        <property type="protein sequence ID" value="KVH93179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMF7"/>
    <dbReference type="STRING" id="59895.A0A103XMF7"/>
    <dbReference type="Gramene" id="KVH93179">
        <property type="protein sequence ID" value="KVH93179"/>
        <property type="gene ID" value="Ccrd_004783"/>
    </dbReference>
    <dbReference type="OMA" id="ECQKESI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009884">
        <property type="term" value="F:cytokinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048509">
        <property type="term" value="P:regulation of meristem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010029">
        <property type="term" value="P:regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048831">
        <property type="term" value="P:regulation of shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000015">
        <property type="entry name" value="Histidine kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.350:FF:000001">
        <property type="entry name" value="Histidine kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="entry name" value="CHASE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056839">
        <property type="entry name" value="Receiver_AHK4/CRE1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF35">
        <property type="entry name" value="HISTIDINE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24896">
        <property type="entry name" value="Receiver_CRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="14">
        <location>
            <begin position="355"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="621"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH93179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134378" checksum="B2963B1E5E702F99" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMT4</accession>
    <name>A0A103XMT4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">XS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_004331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004710">
        <property type="protein sequence ID" value="KVH93617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMT4"/>
    <dbReference type="STRING" id="59895.A0A103XMT4"/>
    <dbReference type="Gramene" id="KVH93617">
        <property type="protein sequence ID" value="KVH93617"/>
        <property type="gene ID" value="Ccrd_004331"/>
    </dbReference>
    <dbReference type="OMA" id="DWYNLQP"/>
    <dbReference type="OrthoDB" id="1936239at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12266">
        <property type="entry name" value="RRM_like_XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2890">
        <property type="entry name" value="XS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044287">
        <property type="entry name" value="SGS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005380">
        <property type="entry name" value="XS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038588">
        <property type="entry name" value="XS_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005381">
        <property type="entry name" value="Znf-XS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46602">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF GENE SILENCING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46602:SF1">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF GENE SILENCING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03468">
        <property type="entry name" value="XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03470">
        <property type="entry name" value="zf-XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Zinc finger-XS" evidence="7">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="XS" evidence="6">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH93617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="621" mass="71517" checksum="209CF0FB33EE45CA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMZ6</accession>
    <name>A0A103XMZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004734">
        <property type="protein sequence ID" value="KVH93583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMZ6"/>
    <dbReference type="Gramene" id="KVH93583">
        <property type="protein sequence ID" value="KVH93583"/>
        <property type="gene ID" value="Ccrd_004365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10480" checksum="9AF7CD8EEBF585D5" modified="2016-04-13" version="1" fragment="single">MGKRLMTMEAVFMEKSRHGGRIREGCHMINKMKGGTIRKLALIVLSIMRPSRKETSSLKMTRKETELHSCWRSISRLESRAHKIDDMAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNN8</accession>
    <name>A0A103XNN8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_003872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004572">
        <property type="protein sequence ID" value="KVH94068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNN8"/>
    <dbReference type="STRING" id="59895.A0A103XNN8"/>
    <dbReference type="Gramene" id="KVH94068">
        <property type="protein sequence ID" value="KVH94068"/>
        <property type="gene ID" value="Ccrd_003872"/>
    </dbReference>
    <dbReference type="OMA" id="RGNYYSY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="8">
        <location>
            <begin position="427"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH94068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="507" mass="56752" checksum="63D9D4A5D23D8A87" modified="2016-04-13" version="1" fragment="single">MPSIAGSRSSPMSIAGGEISSPQKRRLRSNSALSDEPFSSTPSKPCSPLKSKSPRRCVEDSPHRSRANGDKTVANDNLTKMRKSPKKKLLDAFLDKPIWNPTDSEQLSAVKEALHVSTAPSMIMCREDEQKRIEEFCKQCLEQEKAGSLYICGCPGSGKSLLMENVKGSLAVWAKETGGHLPEILAINCTSLSSTSEIFNKVKIYHDIDIHMPRPIVTDVMLKNVDHSEVFNTLAVSRLVIADELDYLTTKDRVVLHDLFMLTTLPFSKVILIGIANAIDLADRFLPKLQSLNCKPMVVSFRAYSMDHIIIILKQRLMALSYTVFQPQALELCARQVDVVLNYKTHTIRILAESSCSIWRYEESSWYLQVGMGAIEMLETELRESACTSNLSSMVRVDHMAIALSRAYKSPIVDTIQSLPQHQQIVLCSAVKLFWRGKKDTTIKELNKSYIDVCKSTLIPPVGIMELSCMCRVLDDQGILKLGQSRDDKLRRLTLQVDEADIIFALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRG1</accession>
    <name>A0A103XRG1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agenet-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004384">
        <property type="protein sequence ID" value="KVH95523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XRG1"/>
    <dbReference type="Gramene" id="KVH95523">
        <property type="protein sequence ID" value="KVH95523"/>
        <property type="gene ID" value="Ccrd_002405"/>
    </dbReference>
    <dbReference type="OMA" id="YWKSDQV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055274">
        <property type="entry name" value="SWO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429:SF1">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1866"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1938"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2061"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2071"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2098"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2110"/>
            <end position="2129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2260" mass="243222" checksum="DC8C2EB7B6F7A4C7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRT6</accession>
    <name>A0A103XRT6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LAZY 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRT6"/>
    <dbReference type="STRING" id="59895.A0A103XRT6"/>
    <dbReference type="Gramene" id="KVH95708">
        <property type="protein sequence ID" value="KVH95708"/>
        <property type="gene ID" value="Ccrd_002218"/>
    </dbReference>
    <dbReference type="OMA" id="CTCLTGQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009630">
        <property type="term" value="P:gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000012">
        <property type="term" value="P:regulation of auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038928">
        <property type="entry name" value="LAZY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34959">
        <property type="entry name" value="PROTEIN LAZY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34959:SF3">
        <property type="entry name" value="PROTEIN LAZY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37364" checksum="88540112F795B70D" modified="2016-04-13" version="1">MGQPSLDDFEYYPKSNYYAKPSSKARETNHRKSFACLEAVRGDDESMEDASAALSVLFHGFLAIGTLGTDPVTSDPATPTFSTSVEYIMEKETEATENELQFINDELEKVLGGEGREDDSSGRNSHVSIGRSSHGSTITLSGKPLEAADNENGAVACPLQGYLFGSAIELTETTTGKKEHRTSLGELFQKTKLAEENTGPKCNRVEKQKEKETDKSAVHLMKKILKGRKASGGTIDTASADKKHKILQMFQRKVHPERTKSQNQSKYAANGTYVNEDGYKKRNQMLSGEDITTFSESEISKKSANNTRSNMPQATCGASDSNGNRECWIKSDAEYLVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRX4</accession>
    <name>A0A103XRX4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004377">
        <property type="protein sequence ID" value="KVH95762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRX4"/>
    <dbReference type="Gramene" id="KVH95762">
        <property type="protein sequence ID" value="KVH95762"/>
        <property type="gene ID" value="Ccrd_002158"/>
    </dbReference>
    <dbReference type="OMA" id="ECRIVEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="24470" checksum="43B122FA43E21FA4" modified="2016-04-13" version="1">MMRKLKFLFLEVIENKNGVFGFEAFDLFEELLKEINVDGNNLLVRAVDALVKAFFSVHQFDEAYDVLLKIQGGFLLSVLTCNLFLNRLVEEGKVDMAMMVYQHLKMKGFLPNVYTYGIVVKGLCRTGCVKEAGDVLESMKEAGAEPNMFTFGSYIDGLCSNGYTDSAFELLKMLKEPGSLIDVFAYASVIRGFVKELKLQDAENDFFNMKQAAIVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSY3</accession>
    <name>A0A103XSY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpene synthase, metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004338">
        <property type="protein sequence ID" value="KVH96283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSY3"/>
    <dbReference type="STRING" id="59895.A0A103XSY3"/>
    <dbReference type="Gramene" id="KVH96283">
        <property type="protein sequence ID" value="KVH96283"/>
        <property type="gene ID" value="Ccrd_001643"/>
    </dbReference>
    <dbReference type="OMA" id="AKWLTYS"/>
    <dbReference type="OrthoDB" id="1921927at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF214">
        <property type="entry name" value="(3S,6E)-NEROLIDOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="253"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="542" mass="62215" checksum="C1CD1A1823545662" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTD1</accession>
    <name>A0A103XTD1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004284">
        <property type="protein sequence ID" value="KVH96493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTD1"/>
    <dbReference type="STRING" id="59895.A0A103XTD1"/>
    <dbReference type="Gramene" id="KVH96493">
        <property type="protein sequence ID" value="KVH96493"/>
        <property type="gene ID" value="Ccrd_001423"/>
    </dbReference>
    <dbReference type="OMA" id="HIKIVPC"/>
    <dbReference type="OrthoDB" id="1858506at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17358" checksum="C677E0766A3B40BB" modified="2016-04-13" version="1">MTSASIEIEIPSSYPADKVFKVFSDFDNIAPKVNPDVFKSIETIEGNGDVGTKKIFTFGDAVPFTSGKYKVDAIDTSNFSYSYSFFEGDCLMGILDSITHHIKIVPCDGGSKFKQTVIYNCKGSDKPSEEILKAEKEIYEKTYKAIEAYGAAHPESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTY0</accession>
    <name>A0A103XTY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, AAA-type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004134">
        <property type="protein sequence ID" value="KVH96848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTY0"/>
    <dbReference type="STRING" id="59895.A0A103XTY0"/>
    <dbReference type="Gramene" id="KVH96848">
        <property type="protein sequence ID" value="KVH96848"/>
        <property type="gene ID" value="Ccrd_001060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="170" mass="18939" checksum="1283BC863934BE01" modified="2016-04-13" version="1">MQRSVSSAKNVYHNLIHYKKPPNVATVTWQRPPCDVFIDHDDINTKKNVAGLLYGKLHLVFEFVETDFEAVIWDRNIVLSPTNMKSYLQMSLKGLATKNGFCIGVLLSGSPGTGKTMLAKAIAKESRVVFINVRVSNLMSKWFGDAQKLGKALGLCTSSLQIMVQCVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVM0</accession>
    <name>A0A103XVM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVM0"/>
    <dbReference type="Gramene" id="KVH97709">
        <property type="protein sequence ID" value="KVH97709"/>
        <property type="gene ID" value="Ccrd_000172"/>
    </dbReference>
    <dbReference type="OMA" id="NPIWCEL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47487">
        <property type="entry name" value="OS06G0651300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47487:SF8">
        <property type="entry name" value="OS08G0270900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="18912" checksum="980F9C9208685A2D" modified="2016-04-13" version="1">MEEEMISLRNIMPVELAIKRELEYRKKMDVSRNQRQNDLKPLVLTQGPPTQPGKEDIELAAKVSRKSPMPQFSSSCRTFQEQLAFSCKACQLTFATVFHLSGHFVGQQHKVNVSLMKKRKEAISNPIWCELCRSSCSSLSEMERHLNGSRHNSLVSEFKNGDLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW49</accession>
    <name>A0A103XW49_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW49"/>
    <dbReference type="STRING" id="59895.A0A103XW49"/>
    <dbReference type="Gramene" id="KVH97971">
        <property type="protein sequence ID" value="KVH97971"/>
        <property type="gene ID" value="Ccrd_023787"/>
    </dbReference>
    <dbReference type="OMA" id="HCITETV"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF41">
        <property type="entry name" value="MITOCHONDRIAL CARRIER DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="93"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31836" checksum="27D60E5EBE8814A8" modified="2016-04-13" version="1">MDGKEFVAGGFGGIGGVVAGYPLDTVRIRQQNGRDGSAFGILRNVVAKEGPFALYKGMGAPLATITFQNALVFQSYATLSRAFDRFIPPTEPPSYKSVALGGTGAGAIQSFVLTPIELVKIRLQLQNQTTPKQSETGPLSLSKHIVRTEGWKGIFRGLKITVLRDAPSFGFYFWTYEYTREQLHPGCRKSGQESCTTMLVAGGLAGVASWLCCYPLDVVKTRLQAQTPTSKIKYDGIVDCFRKSVRDDGNGVLFRGLGSTVSRAFVVNGAVFMAYETALRVLFNTNDSMNNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWS2</accession>
    <name>A0A103XWS2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWS2"/>
    <dbReference type="Gramene" id="KVH98330">
        <property type="protein sequence ID" value="KVH98330"/>
        <property type="gene ID" value="Ccrd_023441"/>
    </dbReference>
    <dbReference type="OMA" id="ICCDSER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="39707" checksum="DC060B278C94CB97" modified="2016-04-13" version="1">MSSNKGEHQTVPLSVLLKREVANEKIERPEIISGQANQSKKGEDFTLIKSECQRVLGDGVTTYSVFGVLDGHNGSAAAIYTKENLLNNVLGAIPPDLNRDEWIAVLPRALVAGFVKTDKDFQEKGQLSGTTVTFVIIEGFVVTVASVGDSRCILESVDGSLHYLSADHRFEDNEEETERVTASGGEVGRLNTGGGTQIGPLRCWPGGLCLSRSIGDLDVGEFIVPVPYVKQVKLSSAGGRLIIASDDKTNPPVPQPKKMTKGVFKVKFIFKKKSSGSTSNMDDEYLEPDVVEEMVEEGSALLSERLDTKYPLCNMFKLFTCAVCQVEMKPGEGISVHAGSSSGRNSRPWDGPFLCTGDTAVEVNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXG1</accession>
    <name>A0A103XXG1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003783">
        <property type="protein sequence ID" value="KVH98611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXG1"/>
    <dbReference type="Gramene" id="KVH98611">
        <property type="protein sequence ID" value="KVH98611"/>
        <property type="gene ID" value="Ccrd_023160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="108" mass="12470" checksum="FEFB1C9ECA1F9160" modified="2016-04-13" version="1">MIYWFPSQHPGTGGIFGSFLLHVLVCIMCRLVAGEDDSGGEVDHHQSTVNENVRMDPQIQMQIARLEARISRVEARMERLEVSVLYMQRRMYLYGFVCLISVLYAIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXZ0</accession>
    <name>A0A103XXZ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH99008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXZ0"/>
    <dbReference type="STRING" id="59895.A0A103XXZ0"/>
    <dbReference type="Gramene" id="KVH99008">
        <property type="protein sequence ID" value="KVH99008"/>
        <property type="gene ID" value="Ccrd_022773"/>
    </dbReference>
    <dbReference type="OMA" id="ENQVWAI"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024593">
        <property type="entry name" value="DUF3444"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056988">
        <property type="entry name" value="Zn_ribbon_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137">
        <property type="entry name" value="BNAC03G44070D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137:SF54">
        <property type="entry name" value="DNAJ DOMAIN, CHAPERONE J-DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11926">
        <property type="entry name" value="DUF3444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23551">
        <property type="entry name" value="Zn_ribbon_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="716" mass="80973" checksum="709F13E8D03F46D8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY97</accession>
    <name>A0A103XY97_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY97"/>
    <dbReference type="STRING" id="59895.A0A103XY97"/>
    <dbReference type="Gramene" id="KVH99031">
        <property type="protein sequence ID" value="KVH99031"/>
        <property type="gene ID" value="Ccrd_022736"/>
    </dbReference>
    <dbReference type="OMA" id="QPREFPQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="269" mass="30220" checksum="ECF59D0A18B3C0DF" modified="2016-04-13" version="1">MVRLTADLIWKSPHFFNALRERELDLRGNKIAVIENLGATEDQFDTIDLSDNEIVKLENFPNLNRLGTLLFNNNRITRINPNIGEFLPKLHSLVLTNNRLVNLVEIDPLASLPKLQFLSLLDNNITKKPNYRLYVIHKLKALRLLDFKKVKQKERIEAASLFASEEAEEEAKKESVKTFVPGEVPTEEPKEEEPSKPVGPTPEQIIAIKALKSGQVPADLNIGNTNKKANNENTTNDMETDGDKEAPVDASKDASSKKETDGPADMEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYL3</accession>
    <name>A0A103XYL3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with CIPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003629">
        <property type="protein sequence ID" value="KVH99259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYL3"/>
    <dbReference type="STRING" id="59895.A0A103XYL3"/>
    <dbReference type="Gramene" id="KVH99259">
        <property type="protein sequence ID" value="KVH99259"/>
        <property type="gene ID" value="Ccrd_022521"/>
    </dbReference>
    <dbReference type="OMA" id="RAWEHQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000073">
        <property type="entry name" value="calcineurin B-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF138">
        <property type="entry name" value="CALCINEURIN B-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="208" mass="23940" checksum="8ECC1F99623676CD" modified="2016-04-13" version="1">MSQCLEGIKHLCASLLHCCDLELYKQSRGLEDPEILARETVFSVSEIEALYELFKKISSAVIDDGLINKEEFQLALFKTNKKESLFADRVFDLFDTKHNGILGFEEFARALSVFHPNAPIDDKIEFSFQLYDLKQQGFIERQEVKQMVVATLAESGMNLSDDVIESIIDKTFEEADTKHDGKIDKEEWRSLVLRHPSLLKNMTLQYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ79</accession>
    <name>A0A103XZ79_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003437">
        <property type="protein sequence ID" value="KVH99606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ79"/>
    <dbReference type="Gramene" id="KVH99606">
        <property type="protein sequence ID" value="KVH99606"/>
        <property type="gene ID" value="Ccrd_022160"/>
    </dbReference>
    <dbReference type="OMA" id="VINQCHV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF52">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="16376" checksum="4B81945DB6EA9228" modified="2016-04-13" version="1">MSEFDLVEYHFTTTQVNELLSFLHSELPANSGSGSGSGSGSGYCDHELETRHRRMVSNRESARRSRQRKKRHLEELIDQLNQLRVGNQDMKNRLNWLQYQCRTVLSQNLQLGSECIHLRSKMFGLCQLLVNMQFQSSFTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZF8</accession>
    <name>A0A103XZF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_022041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the classical AGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003417">
        <property type="protein sequence ID" value="KVH99726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZF8"/>
    <dbReference type="STRING" id="59895.A0A103XZF8"/>
    <dbReference type="Gramene" id="KVH99726">
        <property type="protein sequence ID" value="KVH99726"/>
        <property type="gene ID" value="Ccrd_022041"/>
    </dbReference>
    <dbReference type="OMA" id="FALRITM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044959">
        <property type="entry name" value="AGP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36321:SF2">
        <property type="entry name" value="CLASSICAL ARABINOGALACTAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36321">
        <property type="entry name" value="CLASSICAL ARABINOGALACTAN PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119231" evidence="12">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH99726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="11154" checksum="C15EB434072C743F" modified="2016-04-13" version="1">MAFSSFLTVLMVALIAGSALAQSPTVAPTVSPTATPTASPPSPVSAVPTSSPTVAPLASPPAPPTSLAPGSPIGLPPSISSTPTDSPTSSPPNSASLNRVTVAGSVAVVVLAAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0A0</accession>
    <name>A0A103Y0A0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0A0"/>
    <dbReference type="STRING" id="59895.A0A103Y0A0"/>
    <dbReference type="Gramene" id="KVI00154">
        <property type="protein sequence ID" value="KVI00154"/>
        <property type="gene ID" value="Ccrd_021593"/>
    </dbReference>
    <dbReference type="OMA" id="VKAPEIM"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="220" mass="25032" checksum="3FA52A95A81F7492" modified="2016-04-13" version="1">MEKVRNMFMPKPNPQQLLRDWQRRLRQECRNIERQIRDIQREEKNVQKAIREAAKRNDMGSARALAKEVVRSRKTVNRLYENKAQLNSISMHLGESVAIARTVGYLSKSAEVMKIVNNLMKAPEMAVAMQEFNKEMIKAGIIEEIVDEAIDSALDSDDIEEEIEEEVDKVLTAIAGETAAQLPEATRKERLKQAAADAEEEGVNDEELEELRAGLAKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y107</accession>
    <name>A0A103Y107_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin U/P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003378">
        <property type="protein sequence ID" value="KVI00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y107"/>
    <dbReference type="STRING" id="59895.A0A103Y107"/>
    <dbReference type="Gramene" id="KVI00544">
        <property type="protein sequence ID" value="KVI00544"/>
        <property type="gene ID" value="Ccrd_021208"/>
    </dbReference>
    <dbReference type="OMA" id="LHYEDDQ"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20604">
        <property type="entry name" value="CYCLIN_AtCycU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012389">
        <property type="entry name" value="Cyclin_P/U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF91">
        <property type="entry name" value="CYCLIN-P4-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027110">
        <property type="entry name" value="PREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR027110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="204" mass="23482" checksum="8BADB2287C2C5CA9" modified="2016-04-13" version="1">MAELECPTVMSKLISYLSSLLQRVAESNDLNPRFHPQKISAFHGLTRPTISIQTYLERIFKYANCSPSCYVVAYVYLDRFTQQQPALSVNSFNVHRLLITSVMVAAKFMDDMYYNNAYYAKVGGISTTEMNFLEVDFLFGLGFQLNVNPTTFHTYCSYLQKEMFLLQPPPNIEELSSSSYKSRSTKLLHYEDDQQQQQQEVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1D1</accession>
    <name>A0A103Y1D1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003307">
        <property type="protein sequence ID" value="KVI00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1D1"/>
    <dbReference type="STRING" id="59895.A0A103Y1D1"/>
    <dbReference type="Gramene" id="KVI00734">
        <property type="protein sequence ID" value="KVI00734"/>
        <property type="gene ID" value="Ccrd_021012"/>
    </dbReference>
    <dbReference type="OMA" id="AQWAFGG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC31 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116780" checksum="190BC4293DA90355" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1I5</accession>
    <name>A0A103Y1I5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003224">
        <property type="protein sequence ID" value="KVI00822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1I5"/>
    <dbReference type="STRING" id="59895.A0A103Y1I5"/>
    <dbReference type="Gramene" id="KVI00822">
        <property type="protein sequence ID" value="KVI00822"/>
        <property type="gene ID" value="Ccrd_020924"/>
    </dbReference>
    <dbReference type="OMA" id="VKACTRI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="24138" checksum="E1D5C06F6484F134" modified="2016-04-13" version="1">MRLVNTKRRCLPLSYSLCTKTTVTHSVDATIIKTGFNLKTSRSNFKLTDLVANGQVAQAHQLFDQMLRRNTYSVNTLISGYVKSGNLSRARDLFDGMPVRTEVYWTILIGGYSQHNQPIGAFKLYAEMCRWGTVPDYVTFATLLSCCNETLMTKAVTQVHSHIVKLGFSGTLKVCNSLVDAYCKTGTLELANRLFLEMPIKDTVTFNAMTTGYSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1L4</accession>
    <name>A0A103Y1L4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_020962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01003256">
        <property type="protein sequence ID" value="KVI00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1L4"/>
    <dbReference type="STRING" id="59895.A0A103Y1L4"/>
    <dbReference type="Gramene" id="KVI00786">
        <property type="protein sequence ID" value="KVI00786"/>
        <property type="gene ID" value="Ccrd_020962"/>
    </dbReference>
    <dbReference type="OMA" id="CINMIDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000012">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000109">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000229">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF33">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="277"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="446" mass="49660" checksum="890C1EB93568E99A" modified="2016-04-13" version="1">MVGTEIEGSTNNAHANGLVQNTNGSLEEKVDELRKLLGKTDDDPLRIVSVGAGAWGSVFAAMLQDGYGHLRDKVQIRIWRRSGRSVDRATAQHLFDVINSREDVLRRLLRRCAYLKYVEARLGDRTLYADEILKDGFCLNMIDTPLCPLKVVTNLQEAVWDADIVINGLPSTETHEVFEEISKYWKEKITVPIIISLSKGIEAELQPEPHIITPTQMISRSTGIPMENILYLGGPNIASEIYNKEYANARLCGAEKWRKPLAKFLRQPHFIVWDNGDLVTHEVMGGLKNVYAIGAGMVASLTNESATSKSVYFAHCTSEMIFITHLLAKNPEKLAGPLLADTYVTLLKGRNAWYGQKLAKGELTLDMGDSIKGKGMIQGISAVKAFYELLSQSHLSILHPEEKKPVAPAPLEAILQALRDETMNDPRDRIEIAQTHAFYRPSLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2Q4</accession>
    <name>A0A103Y2Q4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003097">
        <property type="protein sequence ID" value="KVI01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2Q4"/>
    <dbReference type="STRING" id="59895.A0A103Y2Q4"/>
    <dbReference type="Gramene" id="KVI01434">
        <property type="protein sequence ID" value="KVI01434"/>
        <property type="gene ID" value="Ccrd_020294"/>
    </dbReference>
    <dbReference type="OMA" id="ICGYFRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="736"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="771"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="947" mass="106806" checksum="7B00CE838CF3D7B0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3F4</accession>
    <name>A0A103Y3F4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum vesicle transporter, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002682">
        <property type="protein sequence ID" value="KVI01811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3F4"/>
    <dbReference type="STRING" id="59895.A0A103Y3F4"/>
    <dbReference type="Gramene" id="KVI01811">
        <property type="protein sequence ID" value="KVI01811"/>
        <property type="gene ID" value="Ccrd_019898"/>
    </dbReference>
    <dbReference type="OMA" id="MHCIPTQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF72">
        <property type="entry name" value="ENDOPLASMIC RETICULUM VESICLE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="155"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI01811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="38951" checksum="E8E642BE596A69B1" modified="2016-04-13" version="1">MPSSGIMNRVFSRVRNLDAYPKVNEDFYSRTLSGGVITLVSSIAMIFLVFSELGLYLQTVTETKLVVDTSRGEKLHINFDITFPAVSCTLLSLDAIDISGEQHLDIKHSVMKTRIDANGNEIQMRYDRMGTPKIGKPMQKHGGELEHNETYCGSCYGAEKSEDECCNSCEEVREAYRRKGWGLMNPDLIDQCKREGFVQRIKSEEGEGCKVHGSLEVNKVAGNFHFVKSFHLSNIHVGHEGQAFQEDGYNISHKINKLAFGVNYPGIVNPLDGVHWFQGIPNGMYQYFLKVVPTVYTPVRGPVIQSNQFSVTEHYKGPEKLGQRALPGVFFFYDLSAIKVYSQLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3R7</accession>
    <name>A0A103Y3R7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002667">
        <property type="protein sequence ID" value="KVI02006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3R7"/>
    <dbReference type="STRING" id="59895.A0A103Y3R7"/>
    <dbReference type="Gramene" id="KVI02006">
        <property type="protein sequence ID" value="KVI02006"/>
        <property type="gene ID" value="Ccrd_019713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF72">
        <property type="entry name" value="BASIC LEUCINE-ZIPPER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17334" checksum="F6DF5ACD54D925BC" modified="2016-04-13" version="1">MPQILSELFRSEFMINSGYWRRTHLVQSGTATTSSGGSYPIQNSGSHEDLKRLMDQRKRKRMVSNRESARRSRMRKQKHLDDLMIQLSQLRKENNQIISSVSITTQHYMGVEEENSELYGGGGGGTEFVDEFMSYVYANQPILASADMIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3V6</accession>
    <name>A0A103Y3V6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002666">
        <property type="protein sequence ID" value="KVI02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3V6"/>
    <dbReference type="STRING" id="59895.A0A103Y3V6"/>
    <dbReference type="Gramene" id="KVI02037">
        <property type="protein sequence ID" value="KVI02037"/>
        <property type="gene ID" value="Ccrd_019683"/>
    </dbReference>
    <dbReference type="OMA" id="NTENHFA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010471">
        <property type="entry name" value="DUF1068"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32254">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32254:SF14">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06364">
        <property type="entry name" value="DUF1068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="19892" checksum="99687866CDE5B2D0" modified="2016-04-13" version="1">MAVNRAGSCNPAVVKIGIVFLGLSLVGYLLGPPLYWHLLEGLAAVRRSSSAASCPPCNCDCDSDSRPVLSIPQGLGNGSFTEKNFAELLSEELKLREAEALESQQRADMALLEAKKLTSQYQKEADKCNSGMETCEEAREKAEAALASQKQESALWEQRARQRGWKEGGVRARVQSQGGIETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6X0</accession>
    <name>A0A103Y6X0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002337">
        <property type="protein sequence ID" value="KVI03614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6X0"/>
    <dbReference type="STRING" id="59895.A0A103Y6X0"/>
    <dbReference type="Gramene" id="KVI03614">
        <property type="protein sequence ID" value="KVI03614"/>
        <property type="gene ID" value="Ccrd_018080"/>
    </dbReference>
    <dbReference type="OMA" id="RECRIPL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040389">
        <property type="entry name" value="SMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142:SF15">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="69" mass="7679" checksum="4CF9318805F2CA69" modified="2016-04-13" version="1">MEGAYNGGVAVAEEGCATPKHERYRIPSLPLICPPPPKKKRWSAGGERQPPKNGYFRSPEIEIFFARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y829</accession>
    <name>A0A103Y829_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RMA</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein RING membrane-anchor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase RMA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_017436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The RING-type zinc finger domain is responsible for E3 ligase activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01002289">
        <property type="protein sequence ID" value="KVI04244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y829"/>
    <dbReference type="STRING" id="59895.A0A103Y829"/>
    <dbReference type="Gramene" id="KVI04244">
        <property type="protein sequence ID" value="KVI04244"/>
        <property type="gene ID" value="Ccrd_017436"/>
    </dbReference>
    <dbReference type="OMA" id="RMRRQVM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16745">
        <property type="entry name" value="RING-HC_AtRMA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="285" mass="31975" checksum="58A02E94BFBCC1FA" modified="2016-04-13" version="1">MEHRTGAEPSLSHLPSDPISLIAFKFHEASIISSSNQSQRQFPNLRFSTSTSKNYVNQMAMEQYSQETIPQNAFLKENEASLDKWKSSSEVVDESEDSPSAGFDCNICLDSVQDPVVTLCGHLYCWPCIYKWIHHQNSSSETPNKHPQCPVCKNDISQKTLVPLYGRGQTTKPQSDEKTFMIPRRPPSPSCGAYTVPSRQLAPGPTSISNVMINPMSPTTGMLEEMVSGRIFGNSQVSFYAYPNSYNLVPISTQRARRQAMQADRSLGRVCFFLFCCIMLCLIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y908</accession>
    <name>A0A103Y908_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001921">
        <property type="protein sequence ID" value="KVI04752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y908"/>
    <dbReference type="STRING" id="59895.A0A103Y908"/>
    <dbReference type="Gramene" id="KVI04752">
        <property type="protein sequence ID" value="KVI04752"/>
        <property type="gene ID" value="Ccrd_016927"/>
    </dbReference>
    <dbReference type="OMA" id="AMPNTNG"/>
    <dbReference type="OrthoDB" id="776628at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17054">
        <property type="entry name" value="Ubl_AtBAG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000298">
        <property type="entry name" value="BAG family molecular chaperone regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF43">
        <property type="entry name" value="BAG DOMAIN, UBIQUITIN-RELATED DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="5">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00058673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="37570" checksum="2B05936E753B1FB3" modified="2016-04-13" version="1">MMRMRTKTTELTSMKGSSAPKDEGENEWEVRPGGMLVQKRDPDEEQNRIPPPTIRVRVKYRSIYHEIFISSQATFGELKKMLTGPTGLHHEDQKLMYKDKERASKTFLDAVGVKDKSKMVLVEDPISQEKRYLEARKNAKMEKAAKSVSEISLEVDRLAGQVSALESVISKGGKVAEKMVSNLIELLMNQLLKLDEIMVDGDVNLQKKMQVERVQRYVETLDVLKVKNSTAGNKGNENHVPKQAPSQLRPNKESNEHGGNHHPQPQSRRSVGKFSPMAAPAQQQEPSSKNTSGAVVVTTQWETFDSLPTIFPAPPSTSTSTTSQTMQPNFNWDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y912</accession>
    <name>A0A103Y912_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001924">
        <property type="protein sequence ID" value="KVI04744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y912"/>
    <dbReference type="STRING" id="59895.A0A103Y912"/>
    <dbReference type="Gramene" id="KVI04744">
        <property type="protein sequence ID" value="KVI04744"/>
        <property type="gene ID" value="Ccrd_016935"/>
    </dbReference>
    <dbReference type="OMA" id="HVDMTVK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950:SF49">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY C, POLYPEPTIDE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="20114" checksum="68EFAD68281A0760" modified="2016-04-13" version="1">MSKIAEEIKREINSEKITDSQLSKLPYLQASIKEAMRLHPPVPLLLPHMAAETCEVMNYTILKNSKIFVNLWAMGRDPKIWDDPLSFNPERFIGSKLDFKGQDFELLPFGSGRRMCPGMPSGIKSVQLILASLIREFDLILPNDADPKKLGMSEKFGIAMKMENPLKVIFKTKQGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y931</accession>
    <name>A0A103Y931_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hexosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001912">
        <property type="protein sequence ID" value="KVI04784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y931"/>
    <dbReference type="STRING" id="59895.A0A103Y931"/>
    <dbReference type="Gramene" id="KVI04784">
        <property type="protein sequence ID" value="KVI04784"/>
        <property type="gene ID" value="Ccrd_016900"/>
    </dbReference>
    <dbReference type="OMA" id="MTHASEQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000067">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119498" description="Hexosyltransferase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="51449" checksum="9CA369B5ADE227CC" modified="2016-04-13" version="1" fragment="single">MKLSLVSRLGFGLILLLALNHYVQSAPSSGSTKEAYVTLLYGDEFVLGVRVLGKSIRDTRTARDMVVLVSDGVSNYAKKLLKADGWIVTPISLLENPNQVRPTRFWGVYTKLKIFNMTDYKKVVYLDADTIVVKNIDDLFKCGKFCANLKHSERLNSGVMVVEPSEELFKDMVSKVTTLYSYTGGDQGFLNTYYAGFASARVFDPEISPEILNSKPVPEMERLSTLYNADVGLYMLANKWMVDEKELRVIHYTLGPLKPWDWWTSWLLKPILDKLYPHHLNLDLFPRLVQTRSLCDHARHIYYKFRSGGSLSYSAVSSSTINSSQQVPAFLGGVSIFFCFMAAVVALGLGVSVVPRQVKPWTGLLLMYEWTFTVFFLLFGGHQRQVSCDAATWYYGLGMAFLAIATPSIPCIFGITALFSRVVEQWMYGLWRRASRRGGDEELLSNELGLLLGGVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAD0</accession>
    <name>A0A103YAD0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_016224</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. This enzyme participates in both the breakdown and synthesis of glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAD0"/>
    <dbReference type="STRING" id="59895.A0A103YAD0"/>
    <dbReference type="Gramene" id="KVI05437">
        <property type="protein sequence ID" value="KVI05437"/>
        <property type="gene ID" value="Ccrd_016224"/>
    </dbReference>
    <dbReference type="OMA" id="HHGMMST"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="75"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="284"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="386"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI05437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="651" mass="71272" checksum="DE61BBE34A7E6C61" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBU5</accession>
    <name>A0A103YBU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KVI06218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="Ccrd_015439"/>
    </dbReference>
    <dbReference type="OMA" id="VCKFKRS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38398">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38398:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="73" mass="8336" checksum="2C36F9264F9B9AB7" modified="2016-04-13" version="1">MVSKVEGGMKNRQQQWKKSQNQKSQNYRKQIVMQCNKSNTPKFKRSTGYIEDDGFSSAILLLACIACNPSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCS1</accession>
    <name>A0A103YCS1_CYNCS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001745">
        <property type="protein sequence ID" value="KVI06700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCS1"/>
    <dbReference type="Gramene" id="KVI06700">
        <property type="protein sequence ID" value="KVI06700"/>
        <property type="gene ID" value="Ccrd_014946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36813">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36813:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="10307" checksum="FE6956A2884F310E" modified="2016-04-13" version="1">MGCLDCFGGGQEQFAQSAAGRAARAQMQAAAKQASNTNKGEPTLKLRFEPLHGPAALASEDLDPFYCCKTDHEIIYFVGAVADGMTISFRNRNIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEC0</accession>
    <name>A0A103YEC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromatin assembly factor 1 subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEC0"/>
    <dbReference type="STRING" id="59895.A0A103YEC0"/>
    <dbReference type="Gramene" id="KVI07544">
        <property type="protein sequence ID" value="KVI07544"/>
        <property type="gene ID" value="Ccrd_014128"/>
    </dbReference>
    <dbReference type="OMA" id="SETALWC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048366">
        <property type="term" value="P:leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009825">
        <property type="term" value="P:multidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009934">
        <property type="term" value="P:regulation of meristem structural organization"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010026">
        <property type="term" value="P:trichome differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="7">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="8">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="762" mass="86923" checksum="20575A557F8532FE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEU8</accession>
    <name>A0A103YEU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001486">
        <property type="protein sequence ID" value="KVI07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEU8"/>
    <dbReference type="STRING" id="59895.A0A103YEU8"/>
    <dbReference type="Gramene" id="KVI07806">
        <property type="protein sequence ID" value="KVI07806"/>
        <property type="gene ID" value="Ccrd_013831"/>
    </dbReference>
    <dbReference type="OMA" id="HECEEML"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045344">
        <property type="entry name" value="C-JID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058546">
        <property type="entry name" value="RPS4B/Roq1-like_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF195">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20160">
        <property type="entry name" value="C-JID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23286">
        <property type="entry name" value="LRR_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein RPS4B/Roq1-like leucine-rich repeats" evidence="5">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C-JID" evidence="4">
        <location>
            <begin position="391"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="64478" checksum="210D6F048CE25C8D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFN1</accession>
    <name>A0A103YFN1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fantastic four family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001179">
        <property type="protein sequence ID" value="KVI08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFN1"/>
    <dbReference type="STRING" id="59895.A0A103YFN1"/>
    <dbReference type="Gramene" id="KVI08231">
        <property type="protein sequence ID" value="KVI08231"/>
        <property type="gene ID" value="Ccrd_013399"/>
    </dbReference>
    <dbReference type="OMA" id="VERFCIA"/>
    <dbReference type="OrthoDB" id="1303570at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021410">
        <property type="entry name" value="FAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046431">
        <property type="entry name" value="FAF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155">
        <property type="entry name" value="FANTASTIC FOUR-LIKE PROTEIN (DUF3049)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155:SF3">
        <property type="entry name" value="PROTEIN FAF-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11250">
        <property type="entry name" value="FAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAF" evidence="3">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="50947" checksum="7D170C40C5D86EC8" modified="2016-04-13" version="1">MIHKQGIVSILGSDGHEKTTKAASLRRTLSADMSSRRWLAENGVPSAPMMKKIASSEQIAWSEQIVNDSSSSEEDEEECEANRKGEDNPRRVDIWTAIMSQKAQDELVKLPPPYVHPLVKKSASSLSEKSLKVCTESLGSETGSDVFSSYLSSKTSTDENKGDEPQEEVQEMREVEGEESKLVVKPAAACLTTKKAPQARSFPPPLPSLAAAHTEGPSLHMHSRRVDGRLVLEAVSVPPQKYFEAQRQDGRFLLTLINNPKEEQASKINISEEEISQDNYNDIDDEDEDEIGSDINFDSDYKEMGIFKELQPSKTTGGKVMDLQRSTVVVKRMTERDNRIKLNTKAVNLAKLEAVEEEEGCVMAAPPPIMQSLPRTTGLPPLPPPAAATSFNSYQYFWRAKPTVASVIDPLITQHLPPTKTKDLVLLRGNKADCLLPSLKGCKEPRRSLLMWEPFCIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFN5</accession>
    <name>A0A103YFN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001181">
        <property type="protein sequence ID" value="KVI08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFN5"/>
    <dbReference type="STRING" id="59895.A0A103YFN5"/>
    <dbReference type="Gramene" id="KVI08229">
        <property type="protein sequence ID" value="KVI08229"/>
        <property type="gene ID" value="Ccrd_013400"/>
    </dbReference>
    <dbReference type="OMA" id="RTHAVYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34970">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34970:SF5">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11267" checksum="2ACD24D445E2C623" modified="2016-04-13" version="1">MLRTRLVWFTFGFASTAAVMSQFVYRDLLLDRHSLSCQLKQQFDSLESRLSNLESELPKDLKFKASPSLHHMSNNQILDPALGGQSWFILLVYPLSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFS1</accession>
    <name>A0A103YFS1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_013336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001146">
        <property type="protein sequence ID" value="KVI08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFS1"/>
    <dbReference type="Gramene" id="KVI08291">
        <property type="protein sequence ID" value="KVI08291"/>
        <property type="gene ID" value="Ccrd_013336"/>
    </dbReference>
    <dbReference type="OMA" id="YYAVLEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF69">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="363" mass="40098" checksum="5CC9DAE40423A5DD" modified="2016-04-13" version="1">MIGLEDIYKVVAATVPLYVALLLGYGSVRWWKIFTHEQCDAINRFVCFFTLPLFTFEFTAHIDPFKMNYRFIGADAISKVIIVVVLAFWTRFSSKGSYCWCITSFSLSTLTNSLVVGVPLIRAMYGQDYVDLVVQGSVIQAIVWLTFLLFLLECRRSTKTDCSVNIATVELKDLEGNPKSLDDHQVGVAKSSFMSLMKVVSLKLAMNPNSYSCVIGIIWATLSNRFNWPMPIMIEGSVLIMSKAGTGTAMFSMGLFMAKQHKLIACGKTLTVIAILLKFLAGPAAMAVSCIAMGLHGDVLRVAIIQVDTRSPTPAALPQSITSFIYAKEYELHADVLSTAVIFGMIVTLPILVGYYAVLEFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG92</accession>
    <name>A0A103YG92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001107">
        <property type="protein sequence ID" value="KVI08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG92"/>
    <dbReference type="STRING" id="59895.A0A103YG92"/>
    <dbReference type="Gramene" id="KVI08549">
        <property type="protein sequence ID" value="KVI08549"/>
        <property type="gene ID" value="Ccrd_013076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="40059" checksum="A282BDC92240824B" modified="2016-04-13" version="1">MKRGRTLVNKGKKGKTTLHLKNGNNLVSWKIFDTVANPHQIWNSWARFFVNIYLNTNQILHHQKVEFLSTTDDSEVVERLPSSKMEQRKKELDAEGSRKRLAIDDEVFTKTFTQRLRSDRRFQAIHSWRWCHPLPNTSWYFWEINPSAKPASSPDSCTTNSIPPISWISIVWDLRDHLWSVLATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDVANRQSFLNTLKWIEEVRTERGSDVIIVLVGNKTDLVDKRQVSIEEGDGKAREFGVMFVETSAKAGFNIKPLFRKIAAALPGMETLSSTKQEDMVDVNLKSSSNTNQSDQQGGGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIB1</accession>
    <name>A0A103YIB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIB1"/>
    <dbReference type="STRING" id="59895.A0A103YIB1"/>
    <dbReference type="Gramene" id="KVI09609">
        <property type="protein sequence ID" value="KVI09609"/>
        <property type="gene ID" value="Ccrd_012005"/>
    </dbReference>
    <dbReference type="OMA" id="MAMRSII"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045284">
        <property type="entry name" value="At2g27730-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33878:SF6">
        <property type="entry name" value="F1F0-ATPASE INHIBITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33878">
        <property type="entry name" value="OS08G0559000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="12068" checksum="C5F93ADB061ABBFF" modified="2016-04-13" version="1">MIINQNNFSLFTFAQTDPQNSTLTMAMRSTIISRSPPLLHLMQSSNSRLSLCFFSDQGRILEDEERARENLYVKKMEKEKLEKQKQKLEAKEKADKEKAEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIU1</accession>
    <name>A0A103YIU1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cell wall hydroxyproline-rich glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_011746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001038">
        <property type="protein sequence ID" value="KVI09863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIU1"/>
    <dbReference type="STRING" id="59895.A0A103YIU1"/>
    <dbReference type="Gramene" id="KVI09863">
        <property type="protein sequence ID" value="KVI09863"/>
        <property type="gene ID" value="Ccrd_011746"/>
    </dbReference>
    <dbReference type="OMA" id="GFTSNWY"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000224">
        <property type="entry name" value="Leucine-rich repeat extensin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051582">
        <property type="entry name" value="LRR_extensin-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32093">
        <property type="entry name" value="LEUCINE-RICH REPEAT EXTENSIN-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32093:SF121">
        <property type="entry name" value="LEUCINE-RICH REPEAT EXTENSIN-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119765" description="Cell wall hydroxyproline-rich glycoprotein" evidence="14">
        <location>
            <begin position="31"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="15">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI09863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="405" mass="44811" checksum="8498DC4085961641" modified="2016-04-13" version="1">MWSPHPHPHLKFAILLLLLLLSFFTTLSHGAPSPPNPRLQNAYFALQAWKHSITSDPRGFTSNWYGPNVCNYTGVFCAPSLDDSHITTVAGIDLNHANISGSLPEELGYLLTDLSLFHINSNKFCGTVPKSFEKLGLLYELDISNNQFSGKFPLVVLSLPSLKFLDIRFNQFQGDVPSKLYDLKLDAIFINNNLFTSRLPENLGNSPVSVLVFANNDIQGCLPSSIMKMGETLNEIILTNVGLSGCLTPDIGSLKKLTVFDVSYNSLVGMLPESIGDMKSLEQLNVAHNKFSGKIPSSICSLPRLENFTYSDNYFYGEPKICLKLADKDDRKNCIPDRPAQRKVEECKAFYSRPVNCRGCTASPPPPPPPPPPPPPPPPPSPPPPTYKKWVSPHGHHPYTPPLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJM0</accession>
    <name>A0A103YJM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001024">
        <property type="protein sequence ID" value="KVI10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJM0"/>
    <dbReference type="Gramene" id="KVI10284">
        <property type="protein sequence ID" value="KVI10284"/>
        <property type="gene ID" value="Ccrd_011327"/>
    </dbReference>
    <dbReference type="OMA" id="EAQRSEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="414" mass="45686" checksum="DE514477C4F97A93" modified="2016-04-13" version="1">MGTCYSTTGDGRRDRKDGGGDEDDETDRWWKSKSGRKINRKPIDLKFKFGGGGGRGRAAEERALHQKFDSTNEAVFCGVFDGHGPYGHMVARKIRDSLPVLLSTHWKATSDSENGDANGSVHDDEEEDKWCEELEVEEKDRVPEKYLSLKKSILKAFRLMDTELKTHPSIDCFCSGSTAAQDLIIGNLGDSRAVLATRDDENALVAVQLTVDLKPNLPKVARVWLPNSDSPGLAMARAFGDFCLKDFGLISVPDVYYHHITDKDNRSTAARALVDCATRAWRLKYPTSKNDDCAAVCLFLDPKPVPGSQKMETKEPDIGIVPHEPATNPTVLEHSGTVRDSSEIVPFVEPPENKLPEKGVGGSKRSLAECITSNEDEEWSALDGVTRVNSLLSIPRFLTGEKRSNSSRKPVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKB9</accession>
    <name>A0A103YKB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001007">
        <property type="protein sequence ID" value="KVI10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKB9"/>
    <dbReference type="STRING" id="59895.A0A103YKB9"/>
    <dbReference type="Gramene" id="KVI10643">
        <property type="protein sequence ID" value="KVI10643"/>
        <property type="gene ID" value="Ccrd_010953"/>
    </dbReference>
    <dbReference type="OMA" id="CRLECEL"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000051">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000102">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF16">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="483" mass="50565" checksum="9BB0F67F3698E3B4" modified="2016-04-13" version="1">MQSDLGKLFIGGISWDTNEERLKEYFSSYGEVLEAVIMKDHTTGRARGFGFVVFADPVVAEQVTKEKHNIDGRMVEAKKAVPRDDQSTMSRNSSSFQGSPGPGRTRKIFVGGLASTVTEADFKRYFEQFGTITDVVVMYDHNTQRPRGFGFITYDSEDAVDKVLLKTFHELNGKMVEVKRAVPKELSPGPSRSPLGAYPYGLSRTSSFLNGYNQGAYSPNAVGVGGYGVRMDGRFSPIPSARSGFATFGSGYGMGLNFEPGMSGNYGGGTNYNSTLSYGRGMNPYYVGNSNRFGSPISFDGGNGGNTSFFSSNPRNLWGNGGLNYGSNSTGSSGYVGSGSGVIGGGILGNTGLNWGSSPISPQGGGNGSTQSANLGYGGGDNSYGLRGAAYGRNATTNGVPTSSYAASSVGYDGPFSDFYGGSGSVYGGDPTWRSTNNEREGSGSFGGYGLGGGGSDVQTKSSSGYVGGYSVAKRQENRGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKH3</accession>
    <name>A0A103YKH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000994">
        <property type="protein sequence ID" value="KVI10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKH3"/>
    <dbReference type="STRING" id="59895.A0A103YKH3"/>
    <dbReference type="Gramene" id="KVI10835">
        <property type="protein sequence ID" value="KVI10835"/>
        <property type="gene ID" value="Ccrd_010772"/>
    </dbReference>
    <dbReference type="OMA" id="YTCYTSC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16255" checksum="4BCB8F4E7BDBB01E" modified="2016-04-13" version="1">MGKEKDENGTNDDPITGNEFHKLISCRNHMEPYGIDTFSLHTLFGKNLERATRIVDQKGVKKISAETSGRSIFQIIGESKRKEEYLCFPQHYCGCYSFFYDIVNRGEQLYCKHQLAARLAVSLGTCDDVKVSDEQLAQLLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKL2</accession>
    <name>A0A103YKL2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_010804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01000998">
        <property type="protein sequence ID" value="KVI10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKL2"/>
    <dbReference type="STRING" id="59895.A0A103YKL2"/>
    <dbReference type="Gramene" id="KVI10797">
        <property type="protein sequence ID" value="KVI10797"/>
        <property type="gene ID" value="Ccrd_010804"/>
    </dbReference>
    <dbReference type="OMA" id="MDAKPTI"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000616">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase 2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000008">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF5">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="596" mass="62933" checksum="4526B602C6EC2C24" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNE2</accession>
    <name>A0A103YNE2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucomannan 4-beta-mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucomannan synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_009309</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GDP-mannose + (glucomannan)n = GDP + (glucomannan)n+1.</text>
            <dbReference type="EC" id="2.4.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.32" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNE2"/>
    <dbReference type="STRING" id="59895.A0A103YNE2"/>
    <dbReference type="Gramene" id="KVI12294">
        <property type="protein sequence ID" value="KVI12294"/>
        <property type="gene ID" value="Ccrd_009309"/>
    </dbReference>
    <dbReference type="OMA" id="EWWNKER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047259">
        <property type="term" value="F:glucomannan 4-beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048868">
        <property type="term" value="P:pollen tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000057">
        <property type="entry name" value="Glycosyltransferase-like protein, family 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044">
        <property type="entry name" value="GLUCOMANNAN 4-BETA-MANNOSYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044:SF67">
        <property type="entry name" value="XYLOGLUCAN GLYCOSYLTRANSFERASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="657" mass="76145" checksum="85F6F4FC1F2FC57B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTE3</accession>
    <name>A0A118JTE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTE3"/>
    <dbReference type="STRING" id="59895.A0A118JTE3"/>
    <dbReference type="Gramene" id="KVH90221">
        <property type="protein sequence ID" value="KVH90221"/>
        <property type="gene ID" value="Ccrd_007794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF499">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="12829" checksum="3131560B55FB2F50" modified="2016-04-13" version="1">MLNTSGFGWDDAHQCVTVDAQVLEEYLKLKYQNLSIVDLENRIWRSIRRKQSVCGGGEGSLQRSTTAAMGKYAAEIRDPKRNGARVWLGTFDTAIGAAKAYDRDAFEVPGRKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUX0</accession>
    <name>A0A118JUX0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_005804</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004840">
        <property type="protein sequence ID" value="KVH92167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUX0"/>
    <dbReference type="Gramene" id="KVH92167">
        <property type="protein sequence ID" value="KVH92167"/>
        <property type="gene ID" value="Ccrd_005804"/>
    </dbReference>
    <dbReference type="OMA" id="LPRVNMY"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044602">
        <property type="entry name" value="ATL10/ATL72-79-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905:SF7">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH92167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="22231" checksum="A7E4EFED26E97CD5" modified="2016-04-13" version="1">MYQHIATTVRTGVEETAASPTPSRFTGNKSFDANVVMVLSILLCALICSLGLNFVIRCVLRCSSMVHSESIIGLENTPAKSTNIGLNKKALKTFPTVRYWEGLKLPGLDKECVICLSEFVPEELVKILPKCNHGFHARCIDKWLSSHSSCPTCRHSLVQTCQKILSGGACGTSTLPQLQGQESQSISTIVIMPLQPEHPIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUX6</accession>
    <name>A0A118JUX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004808">
        <property type="protein sequence ID" value="KVH92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUX6"/>
    <dbReference type="STRING" id="59895.A0A118JUX6"/>
    <dbReference type="Gramene" id="KVH92739">
        <property type="protein sequence ID" value="KVH92739"/>
        <property type="gene ID" value="Ccrd_005228"/>
    </dbReference>
    <dbReference type="OMA" id="GCIQVKQ"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000013">
        <property type="entry name" value="Hypersensitive-induced response protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF31">
        <property type="entry name" value="HYPERSENSITIVE-INDUCED RESPONSE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="286" mass="31507" checksum="FD4A4E479FAC4270" modified="2016-04-13" version="1">MGQSLGCIQVQQSSVAVKEHFGKFDDVLQPGCHCLPWCLGYRLAGKLSLRVNQLDVHCETKTKDNVFVTMVASIQYRALSDKAADAFYKLSNTKQQIQAYVFDVIRASVPKLQLDDVFLQKDDIARGVEEELEKAMSGYGFEIVQTLIVDIEPDPHVKRSMNEINAAARMRVAANEKAEAEKILQIKRAEGEAESKYLSGLGIARQRQAIVDGLRDSVLAFSNNVPGTSAKDVMDMVLLTQYFDTMKEIGASSKSSAVFLPHGPGAVKDIASQIREGLLQAESVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVY8</accession>
    <name>A0A118JVY8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004764">
        <property type="protein sequence ID" value="KVH93462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVY8"/>
    <dbReference type="STRING" id="59895.A0A118JVY8"/>
    <dbReference type="Gramene" id="KVH93462">
        <property type="protein sequence ID" value="KVH93462"/>
        <property type="gene ID" value="Ccrd_004484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902065">
        <property type="term" value="P:response to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000359">
        <property type="entry name" value="Mitogen-activated protein kinase 1, putative, expressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF44">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE STE-STE11 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="310"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="572" mass="63797" checksum="5CD8D05BA8DA5B81" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWD2</accession>
    <name>A0A118JWD2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01004473">
        <property type="protein sequence ID" value="KVH94991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWD2"/>
    <dbReference type="STRING" id="59895.A0A118JWD2"/>
    <dbReference type="Gramene" id="KVH94991">
        <property type="protein sequence ID" value="KVH94991"/>
        <property type="gene ID" value="Ccrd_002940"/>
    </dbReference>
    <dbReference type="OMA" id="TDDYKHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF81">
        <property type="entry name" value="NUCLEOREDOXIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="7">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH94991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="111" mass="12771" checksum="710462410D242C4A" modified="2016-04-13" version="1">MVLQIHPSELVGKTIGLYFGAHWCPPCCDFIAQLVEAYNDIINNTNQEFEVIFISTDRDRKEFELSLTKVPWLAIPFDDKSREDLCRIFEIKWIPSLILLGPDVRTISTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWK1</accession>
    <name>A0A118JWK1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Peroxidase</fullName>
            <ecNumber evidence="2 11">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_002344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 11">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9 11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2 11"/>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWK1"/>
    <dbReference type="STRING" id="59895.A0A118JWK1"/>
    <dbReference type="Gramene" id="KVH95634">
        <property type="protein sequence ID" value="KVH95634"/>
        <property type="gene ID" value="Ccrd_002344"/>
    </dbReference>
    <dbReference type="OMA" id="NCRFTNK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF84">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990265" description="Peroxidase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH95634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32601" checksum="CF0C22564D89BE3F" modified="2016-04-13" version="1">MKRQGCVFLFFVLIFAFIGVEVTATGLPPESAPLIRQYYKVHNTCANVERFVRFQVKSFWDKDRTITPKLVKLLYADCMVNGCDASILLNGNNTEKASPKNRGLAGFAFIDIVKRVVESRRDGLKSEASWVDLPSPSISWESALAYFTSKGGHMMGRTRCSNVHDRLYNFKNTGKPDPSMESTTLSYLQQQCPKKVRLGQPNPLINLNPENPTHNFTNSYYKRVLANKAVLGVDQQLRYGGDTYELTDQFADSLGDLKGEFAFSMSRMGGLKVLTGTKGQIRRDCRVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWV7</accession>
    <name>A0A118JWV7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004349">
        <property type="protein sequence ID" value="KVH96174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWV7"/>
    <dbReference type="STRING" id="59895.A0A118JWV7"/>
    <dbReference type="Gramene" id="KVH96174">
        <property type="protein sequence ID" value="KVH96174"/>
        <property type="gene ID" value="Ccrd_001726"/>
    </dbReference>
    <dbReference type="OMA" id="ERETHIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="23810" checksum="8A786B28CB68EC15" modified="2016-04-13" version="1">MSTDKARETHVYTAKLSEQAERYEEMVESMKSVAKLDVDLTVEERNLLSVGYKNVIGARRASWRIMSSIEQKEESKGNENYVNLIKGYRRKAASAGASTELPSTHPIRLGLALNFSVFYYEIMNSPERACHLAKQAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDLPEEGGDDKLKNEEGKAAEQEVSTALCLILKELLVAIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXR2</accession>
    <name>A0A118JXR2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXR2"/>
    <dbReference type="STRING" id="59895.A0A118JXR2"/>
    <dbReference type="Gramene" id="KVH97717">
        <property type="protein sequence ID" value="KVH97717"/>
        <property type="gene ID" value="Ccrd_000181"/>
    </dbReference>
    <dbReference type="OMA" id="CSMMDLF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000119">
        <property type="entry name" value="probable pectin methyltransferase QUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1083">
        <property type="entry name" value="METHYLTRANSFERASE PMT4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="602" mass="67867" checksum="314367912BA1316F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYA7</accession>
    <name>A0A118JYA7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase A1</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003804">
        <property type="protein sequence ID" value="KVH98274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH98274">
        <property type="protein sequence ID" value="KVH98274"/>
        <property type="gene ID" value="Ccrd_023507"/>
    </dbReference>
    <dbReference type="OMA" id="ECKIPAS"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000065">
        <property type="entry name" value="Phospholipase A1-II 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033556">
        <property type="entry name" value="PLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828:SF31">
        <property type="entry name" value="PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48408" checksum="E2C956B58A681A8C" modified="2016-04-13" version="1">MASKTYEELHGSNNWDGLLDPLNPDLRTLILGYGDLASAAERALNNNEGSKYAGYSHYGKSSFFKGVMLPWAESKYNVTSFIYATAHVDFPLAFIXRDKSRENSEFESNWMGYVAVSNDEFSKSIGRREICVVWRGTVRTYEWINDILYAGPVPADPLLPSANGKSITSLIGAAIDQPKVMEGWLVIYNTSNPNSPLVKTSARTQLLARVRELLVKYKDEKXSITCVGHSLGASLATVSAFDLAANVATPDIKVSAFVFASPQVGNQAFKNKMEELPNLNVLSIKDINDIVPKWPSKIMEWIDENTILXIPXDVLLYVDVGIDILIDSKKSPFLKEKDGSDILHAFDFHNLEGMLHTVAGYDGKDREFNWQSAEERSLPLVNMSADLLKEEYQIPQSWWVEKNKGMVLNESGDWVLSPVDPDDHDLSPTTTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYC1</accession>
    <name>A0A118JYC1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BYPASS-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ROH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYC1"/>
    <dbReference type="STRING" id="59895.A0A118JYC1"/>
    <dbReference type="Gramene" id="KVH97269">
        <property type="protein sequence ID" value="KVH97269"/>
        <property type="gene ID" value="Ccrd_000642"/>
    </dbReference>
    <dbReference type="OMA" id="PLKCALH"/>
    <dbReference type="OrthoDB" id="694709at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008511">
        <property type="entry name" value="ROH1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31509">
        <property type="entry name" value="BPS1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05633">
        <property type="entry name" value="ROH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="39825" checksum="F7AAE851AB6BE54F" modified="2016-04-13" version="1">MSRSEGPHRPFLPIGNPFKMMMPKSSHLPSRVLSVFEKNLAERFRQLKPNHANDVISFAWMKLASSSICETLDDIRKLIVDLELPICSWDIKWVDMYLDNSLKLLDFCSAYGTDIVRQRFGYVMLKCALLDLDSDNPQKFLQASSSLHEWRQYQSRYDNSKLEDCSDIICKLEETLNLPKIKNIPKAKDLVRAMYGLKVQTIFIFSTFVAAFSASPRSLFDLQVHKQYLWQESFTDLQDVMNGEIKNIHACGRIFPLKELRTIDQNVKKLYPLLHDGLGDIKQEDFESYCLELKENNEKFLVGLDELKSEMDRFFKVVVDGRMALLDNFQQEAPRSGVQQVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0T5</accession>
    <name>A0A118K0T5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003110">
        <property type="protein sequence ID" value="KVI01365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0T5"/>
    <dbReference type="STRING" id="59895.A0A118K0T5"/>
    <dbReference type="Gramene" id="KVI01365">
        <property type="protein sequence ID" value="KVI01365"/>
        <property type="gene ID" value="Ccrd_020350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="10529" checksum="110F897023D37098" modified="2016-04-13" version="1">MLISTMPDLGNTVSMSSLTLSHTSTLDAENPFLMQDESNGRENCVKIKKSVESKSTDDYLGDWVAKNVELGIPESKLVVSFLVGAPKLVEFLYSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K262</accession>
    <name>A0A118K262_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_017841</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K262"/>
    <dbReference type="Gramene" id="KVI03868">
        <property type="protein sequence ID" value="KVI03868"/>
        <property type="gene ID" value="Ccrd_017841"/>
    </dbReference>
    <dbReference type="OMA" id="RMDGNRI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000453">
        <property type="entry name" value="Leucine-rich receptor-like protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000177">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase At1g17230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000416">
        <property type="entry name" value="Probable leucine-rich repeat receptor-like protein kinase At5g63930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF44">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159883" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="27"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="749"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="778"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVI03868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113155" checksum="4B518B290E8CEBAA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2Q9</accession>
    <name>A0A118K2Q9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001913">
        <property type="protein sequence ID" value="KVI04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2Q9"/>
    <dbReference type="STRING" id="59895.A0A118K2Q9"/>
    <dbReference type="Gramene" id="KVI04771">
        <property type="protein sequence ID" value="KVI04771"/>
        <property type="gene ID" value="Ccrd_016905"/>
    </dbReference>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_uS13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="18858" checksum="5FC00832E2AB25D5" modified="2016-04-13" version="1">MAQALATPVAPSLSLICTTSSSFKSSPTSLSFSTFNPPKVGGLSIRCARVGGVEIPNNKRVQYSLQYIHGIGRTRALEILNDLKMENKITKDLSEEELITLRDEVSKYMIEGDLRRFNALAIRRLKEIQCYRGIRHIQGLPCRGQRTKNNCRTLKGKKIAIAGKKKAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K380</accession>
    <name>A0A118K380_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K380"/>
    <dbReference type="Gramene" id="KVI05492">
        <property type="protein sequence ID" value="KVI05492"/>
        <property type="gene ID" value="Ccrd_016102"/>
    </dbReference>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI05492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="37263" checksum="68C858507A9573F0" modified="2016-04-13" version="1">MMESHGVGLRRVLELTFCVAGIWTAYIYQGVLQETVSTKRFGPEKERFEHLAFLNLAQSAVCLIWSFMMIKLWPSGSTGHAPWWSYWSAGITNTIGPAMGIEALKYISYPAQVLAKSSKMIPVMLMGTLVYGIRYSFPEYLCTILVAGGVSAFALAKTSSKTISKLAHPNAPLGYGLCFLNLAFDGFTNATQDSISARYPKTSAWDIMLGMNLWGTIYNLVFMFGWPQASGYQAIQFCKLHPEAAYDILYYCLCGAVGQNFIFFTISRFGSLTNTTITTTRKFVSIVVSSLLSGNPLSRKQWGSVFMVFSGLSYQIYLKWKKLQKMQKKRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3T7</accession>
    <name>A0A118K3T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001830">
        <property type="protein sequence ID" value="KVI06405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3T7"/>
    <dbReference type="STRING" id="59895.A0A118K3T7"/>
    <dbReference type="Gramene" id="KVI06405">
        <property type="protein sequence ID" value="KVI06405"/>
        <property type="gene ID" value="Ccrd_015217"/>
    </dbReference>
    <dbReference type="OMA" id="MEFAGLQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="187" mass="21082" checksum="91100E1583231C96" modified="2016-04-13" version="1">MGCFASKNADSKASRLSRWRATGISFPDEVLELDKSVRTLDLTHNKLVDVPEEISKLINMQRLLLLLNVSHNKLKSLPESTGSCFSLEELQANENSIEELPTSVCSLIHLKSLCLDHNNLKQIPPSLLKDCKALQNISLHGNPISMDQFQQMEGFQEFEDRRKKKFDKQIDSNVMISSKGLDEGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4D4</accession>
    <name>A0A118K4D4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4D4"/>
    <dbReference type="STRING" id="59895.A0A118K4D4"/>
    <dbReference type="Gramene" id="KVI07305">
        <property type="protein sequence ID" value="KVI07305"/>
        <property type="gene ID" value="Ccrd_014271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF14">
        <property type="entry name" value="ALBA DNA_RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="202" mass="22495" checksum="59775F9F468E6B1C" modified="2016-04-13" version="1">MDRYQRVEKPRAEQSIKENEIRITSQGRMRSYITYAMSLLEEKGLSEIVFKAMGRAINKTVTIVDLETTRHVSMIAITLSKKELNTSSIGGSGGRGRGRGRGRGRGRGRVMSGEEAGEEAAIIVDVEGEITVMALIWMLLKMHTIKKHQCKEEGVAVVVVQGVRDTDLMGGARPMQQVKVRKGSLLLILYVCFYSLPVVFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4L4</accession>
    <name>A0A118K4L4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001494">
        <property type="protein sequence ID" value="KVI07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4L4"/>
    <dbReference type="STRING" id="59895.A0A118K4L4"/>
    <dbReference type="Gramene" id="KVI07708">
        <property type="protein sequence ID" value="KVI07708"/>
        <property type="gene ID" value="Ccrd_013929"/>
    </dbReference>
    <dbReference type="OMA" id="DERYECE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="267" mass="30157" checksum="697479DCCA7D9221" modified="2016-04-13" version="1">MGSLQESLNRFKKQQEKCQSTLKSIAGSKTTTKTTAPPPPRAVPASTLAKSPLPAVKFSNDTERLQHINNIRKSPVGAQIKRVIDLLFESRQSFTAEQINEACYVDVKGNKAVFESLAKNPKVNYEGKRFSYKSKHNVRDQKELLRLVRTFAEGIAVADLKDAYPTVMEDLQEDIAYPNDPRVPIKVDDELKGLFRAIELPRDMLDIERELQKNGMKPATNTAKRRVAAQNFGILTKPKQKKKKTEISKRTKLTNAHLPELFRNLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6E4</accession>
    <name>A0A118K6E4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_011072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001017">
        <property type="protein sequence ID" value="KVI10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6E4"/>
    <dbReference type="STRING" id="59895.A0A118K6E4"/>
    <dbReference type="Gramene" id="KVI10531">
        <property type="protein sequence ID" value="KVI10531"/>
        <property type="gene ID" value="Ccrd_011072"/>
    </dbReference>
    <dbReference type="OMA" id="ENCFMEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="39425" checksum="97ACB29A6D0FD811" modified="2016-04-13" version="1" fragment="single">YDKASVVEEKFNELEQEDISIKPSNQNLICTLKNNTDLLACKAEYYHQCGEYQKCFELTSVLLEKDPFHLKSTMVHIAAAMELGHSNELYLMACNLVKDYPQKAISWFSVGCYYYCIKKYDQSRRYFSKATSLDGTFAPGWIGYGNAYAAKEEGDQAMSGYRTAARLFPGKEDSMREIPKLKALISHSFTFFLSLSGTLLFFMQAKAICPSDPLVYNELGVVAYHMKQYKKAVWWFEKTLAHMPSPLNEMWESTVVNLAHSLRKLKRYSEAITYYEKALALSTRSLSTYAGLAYTYHLQDNYTAAITCYHKALWINPDDQFCTEMLTLALVDESRQGVESETYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124R304</accession>
    <name>A0A124R304_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chalcone isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008199">
        <property type="protein sequence ID" value="KVG40999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124R304"/>
    <dbReference type="STRING" id="59895.A0A124R304"/>
    <dbReference type="Gramene" id="KVG40999">
        <property type="protein sequence ID" value="KVG40999"/>
        <property type="gene ID" value="Ccrd_026445"/>
    </dbReference>
    <dbReference type="OMA" id="NIFAGAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG40999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="45252" checksum="E9CEF144EC148C1A" modified="2016-04-13" version="1">MGLDEGRPKFFPVEALSAGRYLYNISSLVDSSPHHSRHWYRPGSVALEETFSCISKFTGTVLQWCASGSNSNISHKVSDCSHGSFPKRCEFSQTSYVFSTKLDLPRIFCNYRKNALQIPEFFNKFSRFAIRQLLGRAKELQFIPALSLAGNLVPPLDNIYRNFLAVSHENGNAVVERSLNHSPCEVEQRRCGDLHYENFNCPAHAVEPRTGIEFPTILDNIFEGSNTSLNMESEQPQSVFQVLVGTGSKTMKIVKIKSLKLYAFDVHPYDVCNKLASKYASLPENEVDKQHKFFSDLLREDISMTIRLVVSCNGIKISTVRDAFEKSLRARLIKMNPDTDYDCLRSFGSLFSEDIPIQALKAIRSVQFIVGICAGLSLTCTSEMVPSLSRQKRRLDKMSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB89</accession>
    <name>A0A124SB89_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005127">
        <property type="protein sequence ID" value="KVH89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB89"/>
    <dbReference type="STRING" id="59895.A0A124SB89"/>
    <dbReference type="Gramene" id="KVH89892">
        <property type="protein sequence ID" value="KVH89892"/>
        <property type="gene ID" value="Ccrd_008121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="18741" checksum="F4332C85106778B9" modified="2016-04-13" version="1">MDMVTRMASEKPVVIFSKSSCSMCHTIKSLLLEFGVNPTIYELDEISKGREIEQALLIVVQNPMVVPAVFIGGQFVGGANEIISLHLQQALQPMLKDAGALWLGVNPAVYDIDEIPKGWEIEQTLLRRGRNPPAVFIGGEFVGGANRIISLHLEQSLQPMLINAGALLEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBE8</accession>
    <name>A0A124SBE8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBE8"/>
    <dbReference type="STRING" id="59895.A0A124SBE8"/>
    <dbReference type="Gramene" id="KVH90431">
        <property type="protein sequence ID" value="KVH90431"/>
        <property type="gene ID" value="Ccrd_007556"/>
    </dbReference>
    <dbReference type="OMA" id="NNDAYES"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18919">
        <property type="entry name" value="bHLH_AtBPE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000100">
        <property type="entry name" value="Transcription factor BEE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024097">
        <property type="entry name" value="bHLH_ZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565:SF340">
        <property type="entry name" value="TRANSCRIPTION FACTOR BEE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="30712" checksum="3BD94548E4EEBAE1" modified="2016-04-13" version="1">MEGFTSNFHSFKPSFSFIDVDQNMELLNQFSIQYDNPSMSSQNFMGFSNDNFFSQQVLPPPDYQFMQTFQPVFQHEKKNVMVIPEPVPLGPVVNGKRKATDVSASSSGNSSPNPVSENEIDEKKYQSSGKGKKAKVSENGEVPKEVVHVRARRGQATDSHSIAERVRRGKINERLRCLQDIVPGCYKSMGMAVMLDEIINYVQSLQNQVEFLSMKLTEASRFPDFDSDSRPVVAYQMGNANGGVKMQRLEEREEIGPVDLSFGSYPSLPYHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBI5</accession>
    <name>A0A124SBI5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBI5"/>
    <dbReference type="STRING" id="59895.A0A124SBI5"/>
    <dbReference type="Gramene" id="KVH90760">
        <property type="protein sequence ID" value="KVH90760"/>
        <property type="gene ID" value="Ccrd_007220"/>
    </dbReference>
    <dbReference type="OMA" id="RIFGHAI"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="846" mass="93460" checksum="B64A195C12502D72" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBK0</accession>
    <name>A0A124SBK0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_007095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SBK0"/>
    <dbReference type="Gramene" id="KVH90881">
        <property type="protein sequence ID" value="KVH90881"/>
        <property type="gene ID" value="Ccrd_007095"/>
    </dbReference>
    <dbReference type="OMA" id="ADSMACH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="12">
        <location>
            <begin position="1540"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="687"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH90881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1920" mass="208722" checksum="12B66212B2ABF804" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCC5</accession>
    <name>A0A124SCC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004775">
        <property type="protein sequence ID" value="KVH93367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCC5"/>
    <dbReference type="STRING" id="59895.A0A124SCC5"/>
    <dbReference type="Gramene" id="KVH93367">
        <property type="protein sequence ID" value="KVH93367"/>
        <property type="gene ID" value="Ccrd_004577"/>
    </dbReference>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176142" evidence="6">
        <location>
            <begin position="21"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="716" mass="76704" checksum="59378C28675D46C9" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCG0</accession>
    <name>A0A124SCG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004634">
        <property type="protein sequence ID" value="KVH93682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCG0"/>
    <dbReference type="STRING" id="59895.A0A124SCG0"/>
    <dbReference type="Gramene" id="KVH93682">
        <property type="protein sequence ID" value="KVH93682"/>
        <property type="gene ID" value="Ccrd_004266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="11890" checksum="173E227CBADAFB40" modified="2016-04-13" version="1" fragment="single">MKIFGFHNASDPLDKLRFLSVMNPSLLGDADELEILSKPDLEKGTNTISFGRDIDHGTIAQSSTSKFLNALKFIGGCLKSFFHEGVTVSIRSPKAIANMTSLSQVGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDA7</accession>
    <name>A0A124SDA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004333">
        <property type="protein sequence ID" value="KVH96326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDA7"/>
    <dbReference type="STRING" id="59895.A0A124SDA7"/>
    <dbReference type="Gramene" id="KVH96326">
        <property type="protein sequence ID" value="KVH96326"/>
        <property type="gene ID" value="Ccrd_001588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="77" mass="8713" checksum="2C7B16D543709B71" modified="2016-04-13" version="1">MLLLDEPTNHLDIETIDSLAEALNEWDGGLVLVSHDFRLINQVAHEIWVCENQAVTRWEGDIMGFKEHLRTKAGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDK3</accession>
    <name>A0A124SDK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003848">
        <property type="protein sequence ID" value="KVH97225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDK3"/>
    <dbReference type="STRING" id="59895.A0A124SDK3"/>
    <dbReference type="Gramene" id="KVH97225">
        <property type="protein sequence ID" value="KVH97225"/>
        <property type="gene ID" value="Ccrd_000676"/>
    </dbReference>
    <dbReference type="OMA" id="ECYLSPP"/>
    <dbReference type="OrthoDB" id="688025at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35486:SF6">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35486">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="34389" checksum="5D7F123DFF553234" modified="2016-04-13" version="1">MRCKKHATDLSTVVGVCASCLRERLLRLIAAQEQAEAQLLANKHGNSDTNPAFPRSVSPYITRRKSDNSVAPDAAVPRPYNKPRLHHSLSDQRFYNSPQIALSTGGCIGNTSSNRKKPSLIRFSSFSNLFRSNNGNGDADSSSREPCGAAGQPTSVTSSPAWFSNVLPGGGSNQKKKSSDVDESSTIAATGVVRKQRCYRNRGMSPVRSFDDGGEDEFSDGSSEYESVESCKQTPRKTPSHPTIRRGSGHRSVSEMIFCLSPLVRASPNRLWNHKGKPPVDGGDGRAPVVPHLSNAKSFCANRSRKLADFGRSDPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDR7</accession>
    <name>A0A124SDR7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_000103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDR7"/>
    <dbReference type="STRING" id="59895.A0A124SDR7"/>
    <dbReference type="Gramene" id="KVH97780">
        <property type="protein sequence ID" value="KVH97780"/>
        <property type="gene ID" value="Ccrd_000103"/>
    </dbReference>
    <dbReference type="OMA" id="QYICHYD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000071">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000221">
        <property type="entry name" value="Zinc finger protein 410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000818">
        <property type="entry name" value="zinc finger transcription factor YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001190">
        <property type="entry name" value="zinc finger transcription factor YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002205">
        <property type="entry name" value="Zinc finger transcription factor YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF1">
        <property type="entry name" value="ZINC FINGER TRANSCRIPTION FACTOR YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH97780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="381" mass="43856" checksum="33F48A5B24963A8B" modified="2016-04-13" version="1">MPFCRSSEFRLSCHRQLQAPARAVVQSPTHFLVPQDVVATGGRCSVMRWITEAQLNAMKEKSKEVEAIEPEPEPTTEVLFLCSYEGCGKTFIDAGALRKHAHIHGERQYVCHYENCGKKFLDSSKLKRHFLIHTGERDFVCPHEGCGKAFSLDFNLRSHMKTHSQENYHICPYPECGKRYAHEYKLKNHIMSHHEKQNNNNMMVEAPLKYVHIQPIEKPPPKAPKASTATYASASSDRPYACPYEGCEKAYIHEYKLNLHLRREHPGHFPEENPKNAHGNNEMDVGSDHDGNTMKREITKSQKQNRPKPNVKLPPAKVVQRKVSTAVGNVIKKQLWPVVKDVYEEEDSEETEEDRDNVEDRWGYGDNNNDEDDDEETEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEJ6</accession>
    <name>A0A124SEJ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEJ6"/>
    <dbReference type="STRING" id="59895.A0A124SEJ6"/>
    <dbReference type="Gramene" id="KVI00243">
        <property type="protein sequence ID" value="KVI00243"/>
        <property type="gene ID" value="Ccrd_021500"/>
    </dbReference>
    <dbReference type="OMA" id="GHAIDRK"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008191692" description="Dirigent protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="192" mass="21162" checksum="147C5C40C3F43C79" modified="2016-04-13" version="1">MTKIFLSLLLPLLIAFPQTFPAAGANPTFLKSVKLNPLKLRTEKLSHFKFYWHDIISGSNPTVVNIVRPPPNNKTSASGFGMVNMIDDPLTEKPEIGSKLLGRAQGFYGVASQEEVGLLMAMNFVFSTGKYNGSTLTVLGNNPVFHKVREMPVIGGSGLFRFARGYVQASTHDFDLKTGDACVEYNVYVLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SES3</accession>
    <name>A0A124SES3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003146">
        <property type="protein sequence ID" value="KVI01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SES3"/>
    <dbReference type="STRING" id="59895.A0A124SES3"/>
    <dbReference type="Gramene" id="KVI01008">
        <property type="protein sequence ID" value="KVI01008"/>
        <property type="gene ID" value="Ccrd_020729"/>
    </dbReference>
    <dbReference type="OMA" id="YLCPKPC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23700">
        <property type="entry name" value="At3g51010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36767">
        <property type="entry name" value="OS05G0126200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36767:SF1">
        <property type="entry name" value="OS05G0126200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="20729" checksum="B4575A3785EFEA59" modified="2016-04-13" version="1">MLFGAIRSIIRPVSRTILLSRPITTTSSAFSKPLFSATYNNEPSPLFRSTHRSHLFWRPASMRTIQSLTDTRFPKRRPVDKPRRKRASLKPSGPYAWVKHVPGEPIPGNQPNEGSVKHRNEKKRIRQRRAFILEANRKKRIQRIERKMAAVARDRAWAERLAELQQLEEDKRKAAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFG6</accession>
    <name>A0A124SFG6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002439">
        <property type="protein sequence ID" value="KVI03168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFG6"/>
    <dbReference type="STRING" id="59895.A0A124SFG6"/>
    <dbReference type="Gramene" id="KVI03168">
        <property type="protein sequence ID" value="KVI03168"/>
        <property type="gene ID" value="Ccrd_018537"/>
    </dbReference>
    <dbReference type="OMA" id="SHWIWPG"/>
    <dbReference type="OrthoDB" id="686813at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34464">
        <property type="entry name" value="OS09G0376300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34464:SF3">
        <property type="entry name" value="OS09G0376300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="19789" checksum="09DC454CCF2ED4C6" modified="2016-04-13" version="1">MSVSLTRFSWWYWCNGKEKEPTISSGSSSDSMKLSSSKKKGTNLTSSSSSKKVKKKWQSREERKRLVDKEYDVVLVPSDGVCLSESEESSYDSDWSIGWMEPHAHEFLQSDSDDVSDNSFAVLVPCYRNDCKAFKMEEEPSNQLLSVLSKLPTGFPAAAEGNEYMEQWLASLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG11</accession>
    <name>A0A124SG11_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001898">
        <property type="protein sequence ID" value="KVI04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG11"/>
    <dbReference type="STRING" id="59895.A0A124SG11"/>
    <dbReference type="Gramene" id="KVI04933">
        <property type="protein sequence ID" value="KVI04933"/>
        <property type="gene ID" value="Ccrd_016742"/>
    </dbReference>
    <dbReference type="OMA" id="AMDPEMK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="53495" checksum="1BBBE09E057B253D" modified="2016-04-13" version="1">MRLCCRLSFLPTAMFSYQSLSLLPPKTILSAAASLTASALLLRTIADDLIPADIHHYFRNLFNRLSTQLTVVIQESDGLTPNHLFQSANLFLATKLSPTTLRIKIHKPEKDDQFTVTVDRNQPIVDVFQTIQCKWILQTESIEVRGNRDSNSRSELRFFELSFHKKHKETILNKYLPYVVKKAKEIKEENKTVKLHTVDYSGTDYWSSVVLNHPATFETMAMDVEKKEELMEDVDMFIKRKDYYRRVGKAWKRGYLFYGPPGTGKSSLVAAMANRLKFDIYDLDLREVQCNSDLRRLLIGTKSRSILVIEDIDCNIGLQSREFNKETANTDDDKITLSGLLNFIDGLWSSCGDERIIVFTTNHKDRLDPALLRPGRMDVHLQMSYCAYGGFKILASTYLQVKEEEQLGLFRRIKELLNKVQVTPAEIAGELMKKGEDVEIVLSNLIRWLEMKEAEIMTAKSPSVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGK0</accession>
    <name>A0A124SGK0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001773">
        <property type="protein sequence ID" value="KVI06646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGK0"/>
    <dbReference type="STRING" id="59895.A0A124SGK0"/>
    <dbReference type="Gramene" id="KVI06646">
        <property type="protein sequence ID" value="KVI06646"/>
        <property type="gene ID" value="Ccrd_015003"/>
    </dbReference>
    <dbReference type="OMA" id="SILDWQC"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044176">
        <property type="entry name" value="TRL4_chloroplastic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47912">
        <property type="entry name" value="THIOREDOXIN-LIKE 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47912:SF1">
        <property type="entry name" value="THIOREDOXIN-LIKE 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="69"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24973" checksum="9DE24B8185A437C4" modified="2016-04-13" version="1">MSWSIHAAVQKQRILPHQTLFSFAKLQNMKTEFKNPSTFLSSPLDRSSMRSWHLKDKTPYDNRSTVSQYQPIQCMANGDLEELSDEDEELCPVECVREIKKDEELLAVLEKAKQAKTLVVVDFYRTSCGSCKYIEQGFAKLCKGSGNEDAAVIFLKHNVIDEYDEQSDIAERLRIKTVPLFHFYKDGILLEAFPTRDKERIKAAIEKYTAAAPATAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHX2</accession>
    <name>A0A124SHX2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000988">
        <property type="protein sequence ID" value="KVI10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHX2"/>
    <dbReference type="STRING" id="59895.A0A124SHX2"/>
    <dbReference type="Gramene" id="KVI10863">
        <property type="protein sequence ID" value="KVI10863"/>
        <property type="gene ID" value="Ccrd_010745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35323">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35323:SF5">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="11988" checksum="FD89FAE9236512EB" modified="2016-04-13" version="1">MVVALAMVERPVVATGRVAAVVGGVGSTDLAAVAGYTPNHSVTDSAAVGGDLAANGEIVAPKSDASDQKCLEIIQKIIEDDMVEKLKVEQCKFYLRKHGLRLTSKKRYPHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHY3</accession>
    <name>A0A124SHY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000966">
        <property type="protein sequence ID" value="KVI10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHY3"/>
    <dbReference type="Gramene" id="KVI10997">
        <property type="protein sequence ID" value="KVI10997"/>
        <property type="gene ID" value="Ccrd_010597"/>
    </dbReference>
    <dbReference type="OMA" id="TDDSHTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="523" mass="58358" checksum="E3B422071FFFBA5B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103F2I8</accession>
    <name>A0A103F2I8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin head, motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01010615">
        <property type="protein sequence ID" value="KVE45662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103F2I8"/>
    <dbReference type="Gramene" id="KVE45662">
        <property type="protein sequence ID" value="KVE45662"/>
        <property type="gene ID" value="Ccrd_023971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0050">Antiport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="239"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVE45662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="39289" checksum="B4D9252FD14ED771" modified="2016-04-13" version="1" fragment="single">MDHFFPCMIIIVATRIKFVTDTGKVDWRHKQRHRDITVSLPLNKKNTDTASIFVPLYPVLSLLSSVVPALSSALPASSSSFITQQVNHRRLLSHVLGCAFFTGGIVHYPKVQSFNQTAAIVSSGLLLMAVMGILFPAVLHFTHTKVHRGKLELALSRFSSCIMLVAYASYLFFQLKSEVLRTDFKLILHIIMLLSLQLEGLHDTVVEQVSGKDHVLNHLSIXAACFTHPEISMVGLTEDLARLAASPTIAFTEPQTITKWLDPESVAVSRDALAKIAYSRLVDKINSSIGQDSSSKYIIAVLDIYGFASFKTNRCFTVSTAVGVLVSTTAVSSWFCHAPVICIYILLRTANKNRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103QJQ3</accession>
    <name>A0A103QJQ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008057">
        <property type="protein sequence ID" value="KVG50699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103QJQ3"/>
    <dbReference type="STRING" id="59895.A0A103QJQ3"/>
    <dbReference type="Gramene" id="KVG50699">
        <property type="protein sequence ID" value="KVG50699"/>
        <property type="gene ID" value="Ccrd_026383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF41">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG50699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="33236" checksum="6442BB3D9069554C" modified="2016-04-13" version="1">MVLKFGKGDRWKKVLDPIFIYLNTVQNRKDPRTFSDDAKNQMFVEIKKCHMIFMLQRTSNLLVNGVPLQFIIGGRSIPLKRAYVGLAPPGDVGSWQRESKIINIIPRVNINLGDLLYEPQRDGPTLWEIGVPDRIAAEFFIPDPNPKYLNRFLLNYRPNRLVMKRVELGMSPCRGKEPTNKVERGEHGIDTGGSGGFGARDDISSFLPVASDSTDFEASLHDARDYEEPQKDICRPGLGWKDPRHEGTFFFDLHRSVRLRLCLPTSMLCGLPAAACATGAVPVLPMCACAPLPPAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SKH5</accession>
    <name>A0A103SKH5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007487">
        <property type="protein sequence ID" value="KVG87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SKH5"/>
    <dbReference type="STRING" id="59895.A0A103SKH5"/>
    <dbReference type="Gramene" id="KVG87849">
        <property type="protein sequence ID" value="KVG87849"/>
        <property type="gene ID" value="Ccrd_026131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="84" mass="9358" checksum="6F4711D44B98A349" modified="2016-04-13" version="1">MYAFVMRPESLPKPYQDFIQKTGPVAQPVYKAVKGCCRGSPVDIALLSSYLSTVKGADFSFIARVSFYHTLFSNSPMHKIMFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103TE01</accession>
    <name>A0A103TE01_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-binding, integrase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007123">
        <property type="protein sequence ID" value="KVH15481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103TE01"/>
    <dbReference type="STRING" id="59895.A0A103TE01"/>
    <dbReference type="Gramene" id="KVH15481">
        <property type="protein sequence ID" value="KVH15481"/>
        <property type="gene ID" value="Ccrd_025927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000012">
        <property type="entry name" value="Methyl-CpG-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396:SF0">
        <property type="entry name" value="METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="MBD" evidence="9">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH15481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="57737" checksum="A8F726506724842E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VVK4</accession>
    <name>A0A103VVK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_025658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006658">
        <property type="protein sequence ID" value="KVH61067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103VVK4"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF398">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF908" evidence="3">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF908" evidence="3">
        <location>
            <begin position="244"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="DUF913" evidence="4">
        <location>
            <begin position="473"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH61067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128329" checksum="830B0E97F3BE0962" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WKW5</accession>
    <name>A0A103WKW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006527">
        <property type="protein sequence ID" value="KVH74162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WKW5"/>
    <dbReference type="STRING" id="59895.A0A103WKW5"/>
    <dbReference type="Gramene" id="KVH74162">
        <property type="protein sequence ID" value="KVH74162"/>
        <property type="gene ID" value="Ccrd_025570"/>
    </dbReference>
    <dbReference type="OMA" id="FSMFHMT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF32">
        <property type="entry name" value="GLUCOSE_RIBITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH74162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="39549" checksum="2EB6A7FD004E3A9E" modified="2016-04-13" version="1" fragment="single">MLYSIASGIGRIPVTEKSCMWSRRLLATRGTLRISSNRVVMNIGSLVERRRCSAFPTLKVKAIGKEEHSEPRFPPQHQETQPGKEYLMKPLPQFSIGRAVCYAFAKEGATIAFTYVKGDEDIDATHTLKIIKEAKTSESNDPMAIPTDLRYNKNCQNVVDEVIAKYGRIDVLINNPAVQYETYSLEDITEDRLERVFRTNVFSYFFMTRHAIKHMKQGSSIINTTSVLAYTGSPKFLDYGSTKGAVVSFTRGLSQKLVNKGIRVNGVAPGPVWTPLQVAALDDEDIVIFGSEVPMDRAAQPYEIAPSYCSLRGSSQLIENGFLIHDHRYTFEVFVGVALLMSKVDNDVAAIASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X3Y6</accession>
    <name>A0A103X3Y6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_025469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01006405">
        <property type="protein sequence ID" value="KVH83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103X3Y6"/>
    <dbReference type="Gramene" id="KVH83720">
        <property type="protein sequence ID" value="KVH83720"/>
        <property type="gene ID" value="Ccrd_025469"/>
    </dbReference>
    <dbReference type="OMA" id="XRIAEVI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="196"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="388" mass="43138" checksum="468174E80C07C91F" modified="2016-04-13" version="1">MNGVAQISKAQQSRRLGSFSEKIDPLSPPFSAYRSHLSPYPSRSHDLLLGFSLLVSPFCPFHSRPALPKPPLLSAIGSHFSNLTSALRSHSVSLRLQSKCRFMGVINVYNGSSLCMIICNNGFSFSPSLDKTSCAFPRNQRKFSCMASSRAAVKEEGKQQLTGDSFIRPHLRELSPYQPILPFEVLSTRLGRKPEEIVKLDANENPYGPPPEVFEALGALKFPYIYPDPESRRLRTALAKDSGVESDYILVGCGADELIDLIMRCVLDPGDSIVDCPPTFTMYEFDAAVNCALPRKVDFSLDVXRIAEVIEHEKPKIIFLTSPNNPDGSVVSEDVLLKILNLPILVVLDEAYIEFSGLDSKMGWVKKHENLIVLRTFSKRAGIFEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC16</accession>
    <name>A0A103XC16_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005681">
        <property type="protein sequence ID" value="KVH87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC16"/>
    <dbReference type="STRING" id="59895.A0A103XC16"/>
    <dbReference type="Gramene" id="KVH87949">
        <property type="protein sequence ID" value="KVH87949"/>
        <property type="gene ID" value="Ccrd_024703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF836">
        <property type="entry name" value="MYOSIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="18214" checksum="8818BB18D0DBF747" modified="2016-04-13" version="1" fragment="single">MNDFRLQICGSQDDCAYNQGFGVLIFNNDFSEGSCVVKKDISLERPGIAGTSIRSDSKIFGTVGSQLPLRLHLLNHRCDVKALEDCLCKRVIVTRDETITKWLDLESVAVSRDALAKIAYSRLFDWLVDKINSSIGQDSSSKYIIAVLDVYGFASFKTNRCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC68</accession>
    <name>A0A103XC68_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HR-like lesion-inducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005632">
        <property type="protein sequence ID" value="KVH88022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC68"/>
    <dbReference type="STRING" id="59895.A0A103XC68"/>
    <dbReference type="Gramene" id="KVH88022">
        <property type="protein sequence ID" value="KVH88022"/>
        <property type="gene ID" value="Ccrd_024594"/>
    </dbReference>
    <dbReference type="OMA" id="HSELEMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008637">
        <property type="entry name" value="HR_lesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474">
        <property type="entry name" value="HR-LIKE LESION-INDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05514">
        <property type="entry name" value="HR_lesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="170" mass="19050" checksum="AE47AB5805BD2EB4" modified="2016-04-13" version="1">MFTVSNSSLHLTQSHQFLSLLRSPFLSRERKLKASSMAFVSFLGRVLFVSVFVLSAWQEFNEFGNDGGSAAKTLVPKFSVFSKHVTAHTGFQIKILVAGAIALKGIGSLLFIFGSTIGAFLLILHQLIATPILYDFYNYDVEKKEFSQLFIKFTQVKHVLQHSELEMPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDX6</accession>
    <name>A0A103XDX6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005323">
        <property type="protein sequence ID" value="KVH88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDX6"/>
    <dbReference type="STRING" id="59895.A0A103XDX6"/>
    <dbReference type="Gramene" id="KVH88965">
        <property type="protein sequence ID" value="KVH88965"/>
        <property type="gene ID" value="Ccrd_024214"/>
    </dbReference>
    <dbReference type="OMA" id="QCAAKDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11071">
        <property type="entry name" value="CYP74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000024">
        <property type="entry name" value="Allene oxide synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF49">
        <property type="entry name" value="INACTIVE LINOLENATE HYDROPEROXIDE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54795" checksum="D4DE321CB388A5D3" modified="2016-04-13" version="1">MSANTMAVNRITASSAPPPPKTSLTSQPTPTSLPLRSIPGSYGLPLLGPLVDRLNYSWFQGPQTFFKKQIEKNQSTVFRTNVPPSFPFFLVNPNVVAVLDCKSFAHMFDMEIIEKKNILVGDFMPSTKFTGDRRVCAYLDPSEPKHQQMDMLKRSSTVWIPTLTSLLDTMWDNIESQLASGPVSYVVPIQKFHFAFLSRCIAGADPQNSPDMAENGYLYMDRWLALQILPTVPINAFQPLVEIFLHSFPYPYFLVSRDYNKLYEFIQKEGKEVIERGQTEFNLSREDAIHNLLFTLGFNAFGGFLIFFLSLLSTLESDKTGVQEKLRNEVREKAGSSGLSFGTVKEMELVQSFVYETLRLNPPVPLQYGRARKDFELSSHDSVFEVKKGELLCGFQPLVMKDPNVFDDPETFVADRFTKEKGKELLNYLYWSNGPQTGETSASNKQCAAKDFVPLTAALFLAHLFLRYDSVTIAGTSFSAVEKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE36</accession>
    <name>A0A103XE36_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005314">
        <property type="protein sequence ID" value="KVH89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE36"/>
    <dbReference type="STRING" id="59895.A0A103XE36"/>
    <dbReference type="Gramene" id="KVH89057">
        <property type="protein sequence ID" value="KVH89057"/>
        <property type="gene ID" value="Ccrd_008930"/>
    </dbReference>
    <dbReference type="OMA" id="MEAWDEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF25">
        <property type="entry name" value="OS07G0418000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="197" mass="22467" checksum="98FEA3AF934C9E64" modified="2016-04-13" version="1">MGDLYALDFDGVLCDSCGESSISAVKAAKVRWPELFATVDSAMEDWIVDQMHIVRPVVETGYENLLLVRLLLEMKIPSLCKSSVAEGLTIEGILENWSKIKPVIMEEWSENRDALVDLFGKVRDEWMEKDLATWVGANSFVEDRLATLKNVIKEPELNGWNLYLGDWGYNTQKEREEAATYSRIQILQLSDFSKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEB0</accession>
    <name>A0A103XEB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005311">
        <property type="protein sequence ID" value="KVH89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEB0"/>
    <dbReference type="STRING" id="59895.A0A103XEB0"/>
    <dbReference type="Gramene" id="KVH89106">
        <property type="protein sequence ID" value="KVH89106"/>
        <property type="gene ID" value="Ccrd_008909"/>
    </dbReference>
    <dbReference type="OMA" id="VPAKQRM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398:SF5">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="431" mass="48563" checksum="E9F0B3EA7B137C00" modified="2016-04-13" version="1" fragment="single">MSLVCGCPILECVYCLGCARWAWKKCLYTAGRESENWGFATATEFDPVPRICRYILAVYEFDIRNPLWAPPGGYGIDPDQVILKKDYDENQGKVSPYMIYIDNDKQEILLLISGLNLAKESDYLLLLDDKLGQAKFDGGYVHNGLLKAAQWVFENECEVLKELVERYEDYTLTFAGHSLGAGVVTLLTILAVKNRDRIGNIERKRIKCFAIAPARCVSLNLAVRYADVINSVVLQDDFMPRTSVALEVLFKSLFCFPCILCGTCLKETCTLQEHMLQDPRRLYAPGRLYHVIVRKPFGVGRISPVVKTAVPVDGRFEHMVLSCHVLSDHSIALMEQEFQNALDQRMERSTSLAIEHSVEYKAALARAAALEVPEAYSPTEYGTFRNVQGGDESKKLPIESLGSSRRRESWDELAGRIFETDESGQMVLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF99</accession>
    <name>A0A103XF99_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005163">
        <property type="protein sequence ID" value="KVH89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF99"/>
    <dbReference type="STRING" id="59895.A0A103XF99"/>
    <dbReference type="Gramene" id="KVH89700">
        <property type="protein sequence ID" value="KVH89700"/>
        <property type="gene ID" value="Ccrd_008306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="6">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="13850" checksum="BFDFD0F09CCE7E40" modified="2016-04-13" version="1">MVSDSELVGRLREFLSTSDLTTTTTPSNEEDKEGNDEEEEEEVDEEKEAAMASVPKKIKHKHKKVKLSVLQFYKVDDSGKVQRLRKECPNAECGAGTFMANHFDRHYCGKCGLTYVYQKAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFY4</accession>
    <name>A0A103XFY4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-adaptin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_007885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Adaptor protein complexes are heterotetramers composed of two large adaptins (beta-type subunit and alpha-type or delta-type or epsilon-type or gamma-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFY4"/>
    <dbReference type="STRING" id="59895.A0A103XFY4"/>
    <dbReference type="Gramene" id="KVH90021">
        <property type="protein sequence ID" value="KVH90021"/>
        <property type="gene ID" value="Ccrd_007885"/>
    </dbReference>
    <dbReference type="OMA" id="NPPEVQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000012">
        <property type="entry name" value="Beta-adaptin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000002">
        <property type="entry name" value="Beta-adaptin-like protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="13">
        <location>
            <begin position="649"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="14">
        <location>
            <begin position="772"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH90021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="884" mass="98135" checksum="CEA814AF077F0B52" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGC9</accession>
    <name>A0A103XGC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGC9"/>
    <dbReference type="STRING" id="59895.A0A103XGC9"/>
    <dbReference type="Gramene" id="KVH90260">
        <property type="protein sequence ID" value="KVH90260"/>
        <property type="gene ID" value="Ccrd_007720"/>
    </dbReference>
    <dbReference type="OMA" id="FVRTFAM"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16987">
        <property type="entry name" value="ANTH_N_AP180_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000019">
        <property type="entry name" value="Clathrin coat assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000005">
        <property type="entry name" value="putative clathrin assembly protein At2g25430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF13">
        <property type="entry name" value="ASSEMBLY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="10">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="636" mass="70116" checksum="8C5333F056A6DBAA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGQ1</accession>
    <name>A0A103XGQ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGQ1"/>
    <dbReference type="STRING" id="59895.A0A103XGQ1"/>
    <dbReference type="Gramene" id="KVH90436">
        <property type="protein sequence ID" value="KVH90436"/>
        <property type="gene ID" value="Ccrd_007589"/>
    </dbReference>
    <dbReference type="OMA" id="HPDPIGM"/>
    <dbReference type="OrthoDB" id="2012141at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36737">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36737:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="13839" checksum="5A2DF4D02E367AE9" modified="2016-04-13" version="1">MSKKGGAALQKDAPWRAPSTGVKPLPKIHHSPLLCLPQNPYTDYAVSLMKHPDPIGHGFGTEAIVEAAGPECIVPGQVTPVKLLGLKVWPIEVDLKFLEPVGKELKNIGKFMDSAVELMNKSFMDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIK5</accession>
    <name>A0A103XIK5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="12">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_006555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01005010">
        <property type="protein sequence ID" value="KVH91423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIK5"/>
    <dbReference type="STRING" id="59895.A0A103XIK5"/>
    <dbReference type="Gramene" id="KVH91423">
        <property type="protein sequence ID" value="KVH91423"/>
        <property type="gene ID" value="Ccrd_006555"/>
    </dbReference>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="13">
        <location>
            <begin position="79"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="13">
        <location>
            <begin position="524"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="835"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH91423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110222" checksum="2117530E464AACED" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK06</accession>
    <name>A0A103XK06_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004856">
        <property type="protein sequence ID" value="KVH92098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK06"/>
    <dbReference type="STRING" id="59895.A0A103XK06"/>
    <dbReference type="Gramene" id="KVH92098">
        <property type="protein sequence ID" value="KVH92098"/>
        <property type="gene ID" value="Ccrd_005878"/>
    </dbReference>
    <dbReference type="OMA" id="DIESMCN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF18">
        <property type="entry name" value="DNA-BINDING PROTEIN MNB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="10709" checksum="A7DB77A491AE11C4" modified="2016-04-13" version="1" fragment="single">MLYGWGSTRFLLPSPLLIRFSILDSISKDQTMKEGKSSGGTRKADTKLAVKKTQAKGKAVKDPNKPKRPASAFFLFMEEFRKQFKEENPGNKSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL89</accession>
    <name>A0A103XL89_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucose-6-phosphate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_005112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL89"/>
    <dbReference type="STRING" id="59895.A0A103XL89"/>
    <dbReference type="Gramene" id="KVH92791">
        <property type="protein sequence ID" value="KVH92791"/>
        <property type="gene ID" value="Ccrd_005112"/>
    </dbReference>
    <dbReference type="OMA" id="PDEVCIF"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="498" mass="57207" checksum="0AA9C6B6200E3138" modified="2016-04-13" version="1">MFAEEKELRLVHLPRLRMESSDSKPETGCLSIIVLGASGDLAKKKTFPALFHLHRQGFFESHDVHIFGYARSKMSDDEVRNRLRGYLTPCQGCEIIREEDASKFMGLIKYVSGPYDAEEGFLLLDKEISAIEDKTERSSRRLFYFALPPSVYPTVCKMIKSCCMSKCHLVISPADKGGWTRIVVEKPFGRDLDSAEALSTQIGELFDESQIYRIDHYLGKELVQNLLVLRFANRLFMPLWNHDNISNVQIVFKENFGTEGRGGYFDQYGIIRDILQNHLLQVLQSVLPINDEEVVIGQYEGYKDDPTVPKDSNTPTFATMVIRIHNERWEGVPFILKAGKSLNSKKAEIRVQFKDVPGDIFKSKKLGRNEFVIRLQPYEAIYMKLTVKEPGLEMKTALSELDLSYRQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPYLHKIDKKEVHSVPYKAGSRGPVEADKLAEKVGYVQTHGYVWIPPTLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLM2</accession>
    <name>A0A103XLM2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004797">
        <property type="protein sequence ID" value="KVH93066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLM2"/>
    <dbReference type="STRING" id="59895.A0A103XLM2"/>
    <dbReference type="Gramene" id="KVH93066">
        <property type="protein sequence ID" value="KVH93066"/>
        <property type="gene ID" value="Ccrd_004919"/>
    </dbReference>
    <dbReference type="OMA" id="PIMISEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF31">
        <property type="entry name" value="NUCLEIC ACID-BINDING, OB-FOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="78"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="195" mass="21400" checksum="AEA25585E71918F6" modified="2016-04-13" version="1" fragment="single">GQWRGSRNGICVKLHQVCRAQTPGGNRNDQILKTHSIFQSIRTSIPISMASNNSQPQGSSSPAKPGLRKPVFTKVDNLKPGTTGLTLVVKVLSSEIVLQKGRAASPNLRNVRISECLVGDETGTILFTARNDQVDLMKPGTCVIIRNGKIDMFKGSMRLAVDRWGRIEVTEPVTFEVKDDNNLSLVEYELVKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM85</accession>
    <name>A0A103XM85_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAR-binding filament-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004780">
        <property type="protein sequence ID" value="KVH93319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM85"/>
    <dbReference type="STRING" id="59895.A0A103XM85"/>
    <dbReference type="Gramene" id="KVH93319">
        <property type="protein sequence ID" value="KVH93319"/>
        <property type="gene ID" value="Ccrd_004624"/>
    </dbReference>
    <dbReference type="OMA" id="MHDSVNV"/>
    <dbReference type="OrthoDB" id="4115at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598:SF2">
        <property type="entry name" value="MAR-BINDING FILAMENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43197" checksum="371672EC54A6D45A" modified="2016-04-13" version="1">MAAFAACFFSCGSSFPSLSSPSSSSSSFALRPNHLVSFPRLRVGKISKDLINVKTLVFASSDGIRAHEEDSSSKRSVLLKLIQEIEPLDVSIIQKDVPPTTVDAMKRTISGMLGLLPSDQFQVLIEALWKPLSKLLVSSLMTGYTLRNAEYRLCLERNFDTDEESTDKQAIEDSKSEVLRTLLHNNIITNRGDQDELHKPEKISENASQIPDLGQMTPEVQQYILKLQSRLFSVKKELHEVKRKNAALQMQQFVGEEKNELLDYLRSLQPEKVAELSEPTSADLKETIHSVVHGLLATLSPKMHSQAPHISESTSIGTASTGIGNDVVENTSIQFQPLVSLSRDYLARLLFWCMLLGHYLRGLEYRVELMELLSMSSNEASDGEHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMA9</accession>
    <name>A0A103XMA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004775">
        <property type="protein sequence ID" value="KVH93377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMA9"/>
    <dbReference type="Gramene" id="KVH93377">
        <property type="protein sequence ID" value="KVH93377"/>
        <property type="gene ID" value="Ccrd_004581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118911" evidence="2">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="261" mass="28751" checksum="D9578C0BF493AD25" modified="2016-04-13" version="1">MQSSLYCLTWFLHWALDEDVCATYTFSSVAVAGLAGDLWVHATRNSCDAYLWLSFWLLQPCSIIHKPELMLSAAPIEFQLLVSTVWFCYASVTLISIVSLFQLADSSLFLFWVIPDLVICILLFHLPVAVLAACNNDVTGYSFSLTLDAIDQGRNGAGEEWCRGEGDGEGKSTVVLRGGGGLTKMNSALQVVQGKQKIVQGLIPVVLLQILKLLPQLNCFSLPKLIIIASFGRDTRMEKEFASGIHGVKEVPNMDARIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNT0</accession>
    <name>A0A103XNT0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein EARLY FLOWERING 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EARLY FLOWERING 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004577">
        <property type="protein sequence ID" value="KVH94033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNT0"/>
    <dbReference type="STRING" id="59895.A0A103XNT0"/>
    <dbReference type="Gramene" id="KVH94033">
        <property type="protein sequence ID" value="KVH94033"/>
        <property type="gene ID" value="Ccrd_003935"/>
    </dbReference>
    <dbReference type="OMA" id="NHESKMS"/>
    <dbReference type="OrthoDB" id="1895690at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042753">
        <property type="term" value="P:positive regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040462">
        <property type="entry name" value="EARLY_FLOWERING_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009741">
        <property type="entry name" value="EARLY_FLOWERING_4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33469">
        <property type="entry name" value="PROTEIN ELF4-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33469:SF16">
        <property type="entry name" value="PROTEIN ELF4-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07011">
        <property type="entry name" value="Elf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein EARLY FLOWERING 4" evidence="6">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="105" mass="11608" checksum="4D8B4AA5A1BF2FD1" modified="2016-04-13" version="1">MEGNGGAHLDGKVLQTFQKSFVQVQNILDQNRVLINEINQNHESKIPDNLSKNVGLIRELNNNIKKVVGLYSDLSSNFSKSIDVNSSEGDSRSDGKAVQKRTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPA3</accession>
    <name>A0A103XPA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPA3"/>
    <dbReference type="Gramene" id="KVH94459">
        <property type="protein sequence ID" value="KVH94459"/>
        <property type="gene ID" value="Ccrd_003505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16094" checksum="64EED3694D14EEB0" modified="2016-04-13" version="1">METFESCIELEWNPTRLMNRRRRGGGKREEERSSGPAKTRLPIAPTSQTNRGHCTDIFSKGSWLSLMNLRQHSTVSNRHFSQQLAQFIIVPHSQLNMPRSDPVLLIFEDGGEVNRTTRSDTFCISAGFKVPGNSADGELKTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPJ3</accession>
    <name>A0A103XPJ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004552">
        <property type="protein sequence ID" value="KVH94475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPJ3"/>
    <dbReference type="STRING" id="59895.A0A103XPJ3"/>
    <dbReference type="Gramene" id="KVH94475">
        <property type="protein sequence ID" value="KVH94475"/>
        <property type="gene ID" value="Ccrd_003463"/>
    </dbReference>
    <dbReference type="OMA" id="YRAHLAW"/>
    <dbReference type="OrthoDB" id="696085at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF160">
        <property type="entry name" value="IQ MOTIF, EF-HAND BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="5">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="283" mass="32448" checksum="67E149017A4D4A32" modified="2016-04-13" version="1">MNHNYHALDIPDAKGNDHKEDKNQHTLALAVAMTVAAKAAVAAANAATELARLVRSSEDLEWRTKNVAAIKIQSFYRAHLAWKALVGLRGVLKLQAVIRGQIVRRKVLNRMNNIQQFENARARVHRIRVPTFDQVSRICNDKKDHFTPHKERKDDQILESPTTIRNHRFDSQMCEMQRKLGLENKHHNSPTSRTQMSYYTKRHYHLSPDRSDDTSLPNSPIFPTYMATTESFMAKARSLSTPRQRLSFLDSCCNHSSSLATPMLSSSSSFNDGMKRNYRHMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPR3</accession>
    <name>A0A103XPR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Photosystem antenna protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004546">
        <property type="protein sequence ID" value="KVH94580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPR3"/>
    <dbReference type="STRING" id="59895.A0A103XPR3"/>
    <dbReference type="Gramene" id="KVH94580">
        <property type="protein sequence ID" value="KVH94580"/>
        <property type="gene ID" value="Ccrd_003357"/>
    </dbReference>
    <dbReference type="OMA" id="HEIFVHH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.680.10">
        <property type="entry name" value="Photosystem II CP47 reaction center protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="Photosystem II antenna protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="11057" checksum="72CF3DE3895A316D" modified="2016-04-13" version="1">MDNGDGIAVGWFPIFRDKEGRELFVRRMPTFFETFSVVLIDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPVTVKKYARRAQLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQR1</accession>
    <name>A0A103XQR1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thaumatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQR1"/>
    <dbReference type="STRING" id="59895.A0A103XQR1"/>
    <dbReference type="Gramene" id="KVH95151">
        <property type="protein sequence ID" value="KVH95151"/>
        <property type="gene ID" value="Ccrd_002763"/>
    </dbReference>
    <dbReference type="OMA" id="IAPQCPN"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09217">
        <property type="entry name" value="TLP-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000003">
        <property type="entry name" value="Thaumatin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017949">
        <property type="entry name" value="Thaumatin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00316">
        <property type="entry name" value="THAUMATIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119031" evidence="4">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="87"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="222" mass="24156" checksum="D0FBF45381C9D51A" modified="2016-04-13" version="1">MASSTTLSTCLLLALLFGFSNAATFDIRNNCRYTVWAGAVPGGGQRLNPGQVWSINVPAGTTQARIWPRTGCNFDRSGRGHCQTGDCNGLLRCQAYGAPPNTLAEYALNQYNNLDFFDISLVDGFNVPMEFSPNSGRCRGIRCTADINGQCPNQLRAPGGCNNPCTVYKSDNYCCNSGRCSATDFSRFFKNRCPDAYSYPKDDATSTFTCPGGTNYRVVFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRN6</accession>
    <name>A0A103XRN6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRN6"/>
    <dbReference type="STRING" id="59895.A0A103XRN6"/>
    <dbReference type="Gramene" id="KVH95626">
        <property type="protein sequence ID" value="KVH95626"/>
        <property type="gene ID" value="Ccrd_002279"/>
    </dbReference>
    <dbReference type="OMA" id="FCREFYV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="480" mass="53066" checksum="FC06A03E0D1FB290" modified="2016-04-13" version="1">MENVKQQQPLLAGDNGRNNYTNLKQFPAAPENVEAEDRGVEINGVKDFCREFYVESKKLWYLAGPAIFTSICQYTVGATTQLFAGQLGTMQLAAVSVENSVIGGFSFSILFGMGSALETLCGQAYGAGKFEMLGVYLQRSWVVLNTIAVILMFTYIFGVSVLRLLRQTPSIATAAGRFSVWMIPQLFAYATLIPIAKFLQAQSNIMPMAWIALVAVVSHVFLSWLLMMKLGWGLVGAAVVLDCSWWFMTVAQLTYVLWGSCGQAWGGFSWEAFHNLKGFVRVSFATAVMFCLENWYLMSLVLFAGYFENAEASVDALSVCLNILGWICTVALGLNVACKGVERTRLQKAENCEVRGYSRGIDFSSNWTPLHGGSSSVQKTIPGVVYKQSRRVAIGAGWQTAVAYMNVGSYFFFGIPMSLLMGFRLDMGVKGIWYGMVSGATMQCCLLLIMVSRTNWNEEVNIVGHRIKQWGGDIQQRSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSE8</accession>
    <name>A0A103XSE8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004364">
        <property type="protein sequence ID" value="KVH96030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSE8"/>
    <dbReference type="Gramene" id="KVH96030">
        <property type="protein sequence ID" value="KVH96030"/>
        <property type="gene ID" value="Ccrd_001898"/>
    </dbReference>
    <dbReference type="OMA" id="LAANHHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000543">
        <property type="entry name" value="Armadillo repeat only 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056694">
        <property type="entry name" value="DUF7792"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46168:SF8">
        <property type="entry name" value="ARMADILLO REPEAT ONLY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46168">
        <property type="entry name" value="ARMADILLO REPEAT ONLY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25055">
        <property type="entry name" value="DUF7792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="3">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="950" mass="106153" checksum="A744502E12CD8CE9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSS8</accession>
    <name>A0A103XSS8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004347">
        <property type="protein sequence ID" value="KVH96213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XSS8"/>
    <dbReference type="Gramene" id="KVH96213">
        <property type="protein sequence ID" value="KVH96213"/>
        <property type="gene ID" value="Ccrd_001700"/>
    </dbReference>
    <dbReference type="OMA" id="RGHQIQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1400"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1404"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1686" mass="189832" checksum="FE5D21A33794A73D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT84</accession>
    <name>A0A103XT84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex 1 LYR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004312">
        <property type="protein sequence ID" value="KVH96420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT84"/>
    <dbReference type="STRING" id="59895.A0A103XT84"/>
    <dbReference type="Gramene" id="KVH96420">
        <property type="protein sequence ID" value="KVH96420"/>
        <property type="gene ID" value="Ccrd_001496"/>
    </dbReference>
    <dbReference type="OMA" id="TNFMQHE"/>
    <dbReference type="OrthoDB" id="190541at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20251">
        <property type="entry name" value="Complex1_LYR_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47579">
        <property type="entry name" value="COMPLEX 1 LYR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47579:SF3">
        <property type="entry name" value="COMPLEX 1 LYR PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="88" mass="10365" checksum="B72D9718AD118704" modified="2016-04-13" version="1">MPSLQTALPPELANNAIRLYRECLRRAKYIGHKQHNTELVVQMVRQQFRKHLHETDPEKIQKLKDDAARGLINHILYEAEEMTGRKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTD9</accession>
    <name>A0A103XTD9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004278">
        <property type="protein sequence ID" value="KVH96509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTD9"/>
    <dbReference type="STRING" id="59895.A0A103XTD9"/>
    <dbReference type="Gramene" id="KVH96509">
        <property type="protein sequence ID" value="KVH96509"/>
        <property type="gene ID" value="Ccrd_001408"/>
    </dbReference>
    <dbReference type="OMA" id="ACTLNNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040361">
        <property type="entry name" value="TPD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33184:SF72">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33184">
        <property type="entry name" value="PROTEIN TAPETUM DETERMINANT 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24068">
        <property type="entry name" value="TPD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="106" mass="11709" checksum="2E1BC13B25FCAFF4" modified="2016-04-13" version="1">MGWGYGQCELKDITVGTERTSIQIEGKQEWNVSFINSCKCPQQSLTVSCNGFQSVEKVDPNIFAPVANNNCIVNGGRPIAAFATVWFLYAWDPPFIFVPVSSQVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTT7</accession>
    <name>A0A103XTT7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ELK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TALE/KNOX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004206">
        <property type="protein sequence ID" value="KVH96771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTT7"/>
    <dbReference type="STRING" id="59895.A0A103XTT7"/>
    <dbReference type="Gramene" id="KVH96771">
        <property type="protein sequence ID" value="KVH96771"/>
        <property type="gene ID" value="Ccrd_001138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000076">
        <property type="entry name" value="Homeobox protein knotted-1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005540">
        <property type="entry name" value="KNOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03789">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03790">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01255">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51213">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="35751" checksum="EFAAFD5CDE79BFF0" modified="2016-04-13" version="1">MDGHAGGGGGGTSSLMGFGENNSLNRSSNGDNNNSIGSLCLPPPVIYNNTLIFSTQDHHHHHNNCGTSASAMMLEDNNNSNINDGGGLGFISSSSSCSSSVKAKIMSHPHYPRLLSAYLNCQKIGAPPEVVERLEEACRASVMMAGRASTGGGGGGMNTTIVGQDPALDQFMEAYSCGEGGMDRNVSSEEEVDVDVNNNMVDPQAEDRELKGQLLRKYSGYLGSLKQEFMKKRKKGKLPKEARQQLLDWWTRHYKWPYPSEAQKLALAESTGLDQKQINNWFINQRKRHWKPSEDMQFVVMDAAHPHYFMDNIFGNPYPMDVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU08</accession>
    <name>A0A103XU08_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004128">
        <property type="protein sequence ID" value="KVH96876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU08"/>
    <dbReference type="STRING" id="59895.A0A103XU08"/>
    <dbReference type="Gramene" id="KVH96876">
        <property type="protein sequence ID" value="KVH96876"/>
        <property type="gene ID" value="Ccrd_001033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF9">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15897" checksum="B1E44072CB5CAF76" modified="2016-04-13" version="1">MSRLASAENHALSQSMMRSSYLMKGLRLLFMSSTKITLTHDSLTSTLQAFQHHKEIKVSFCITLRKCLDFADVMILPNGPCCQVREDGQCLLNSRPCSIRALSIFYDGLHPSEIANTVVATRSCIAISAMDTSPYDISHLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU19</accession>
    <name>A0A103XU19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004129">
        <property type="protein sequence ID" value="KVH96869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU19"/>
    <dbReference type="STRING" id="59895.A0A103XU19"/>
    <dbReference type="Gramene" id="KVH96869">
        <property type="protein sequence ID" value="KVH96869"/>
        <property type="gene ID" value="Ccrd_001037"/>
    </dbReference>
    <dbReference type="OMA" id="KQLIGWT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000015">
        <property type="entry name" value="Aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF800">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119113" evidence="5">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="382" mass="42257" checksum="8447F9907D778AF5" modified="2016-04-13" version="1">MKPGIVVVLALMVLVLCVPPSSASDYRRQKWWKWPSSGKSICSSVVLPLYGNVYPQGYYYAQINVGHPSRPYFVDPDTGSDLTWLQCDAPCVHCTQAPHAYYRPNNDLVPCKDPLCASLHSGDHRCDDPNQCDYEVEYADGGSSLGVLVNDVSLLNLTNGIQIAPRLAIGCGYDQIPGPSYQPLDGVLGLGKGKTGIVSQLHSQGLIKNVVGHCFSSRGGGFLFFGDDIYDSSRVISTPMSRDYSGSSYTYLSSQAYEGLLYLPIREAVEDETLPFCWKGRRPFRSMKDVRKYFKPLALSFSSGWRSKTQFEIPLEGYLLISSKGSVCLGVLNGTEVGLENFNIIGDISMQDKMVIYDNEKQTIGWLPANCDRLPMYDTLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWT7</accession>
    <name>A0A103XWT7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWT7"/>
    <dbReference type="Gramene" id="KVH98324">
        <property type="protein sequence ID" value="KVH98324"/>
        <property type="gene ID" value="Ccrd_023447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36744">
        <property type="entry name" value="CYTOCHROME OXIDASE ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36744:SF2">
        <property type="entry name" value="CYTOCHROME OXIDASE ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13159" checksum="5854B9A42F50FDC3" modified="2016-04-13" version="1">MALKNTKKNQKVVKDAEICPEIPPIAAKCLINFAYFIGEDGVLRGGDEKTGRRSGRRDCLLIRMAGFGRLAPKTKNMVVAGGLTGFVFGVYFYTMRAVGGSDELQVAIDKFESQKIKNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXY5</accession>
    <name>A0A103XXY5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH98993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXY5"/>
    <dbReference type="STRING" id="59895.A0A103XXY5"/>
    <dbReference type="Gramene" id="KVH98993">
        <property type="protein sequence ID" value="KVH98993"/>
        <property type="gene ID" value="Ccrd_022788"/>
    </dbReference>
    <dbReference type="OMA" id="PICLRIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="PFYRE" evidence="3">
        <location>
            <begin position="373"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="467"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="542" mass="60864" checksum="D9167DC028590DB1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY26</accession>
    <name>A0A103XY26_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
            <ecNumber evidence="6">1.1.1.267</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_022851</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:13719"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY26"/>
    <dbReference type="STRING" id="59895.A0A103XY26"/>
    <dbReference type="Gramene" id="KVH98953">
        <property type="protein sequence ID" value="KVH98953"/>
        <property type="gene ID" value="Ccrd_022851"/>
    </dbReference>
    <dbReference type="OMA" id="FIDGSVM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051484">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.10:FF:000006">
        <property type="entry name" value="1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000183">
        <property type="entry name" value="1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525:SF0">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="14" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal" evidence="16">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DXP reductoisomerase C-terminal" evidence="17">
        <location>
            <begin position="233"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="37617" checksum="64F97C42EB4EA1A2" modified="2016-04-13" version="1">MSLNFLSPTQTKLITFSDTSKSQNHLLNLQGGFCFKRKDVKVAIGKGIRCSAQPAPPPAWPGTALVDPGVKNWDGPKPISIVGSTGSIGTQTLDIVAENPDKFRVVALAAGSNVTLLAEQVIMVNESLVNELKEALADADYMPEIIPGEQGVIEVARHPDCVTVVTGIVGCAGLTPTVAAIEAGKNIALANKETLIAGGPFVLPLARKHNVKILPADSEHSAIFQDSSVLAQLGWPDMRLPILYTLLGSLTFKAPDNVKYPSMDLSYSAGRAGGTMTGVLSAANEKAVEMFIDEKIKYLDIFKVVELTCEKHQSELVTAPSLEEIIHYDLWAREYAASVKPSSTTGLTPAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ47</accession>
    <name>A0A103XZ47_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Peroxidase</fullName>
            <ecNumber evidence="4 16">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_022197</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14 16">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="14 16">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 16"/>
    <dbReference type="EMBL" id="LEKV01003439">
        <property type="protein sequence ID" value="KVH99572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ47"/>
    <dbReference type="STRING" id="59895.A0A103XZ47"/>
    <dbReference type="Gramene" id="KVH99572">
        <property type="protein sequence ID" value="KVH99572"/>
        <property type="gene ID" value="Ccrd_022197"/>
    </dbReference>
    <dbReference type="OMA" id="PEYAIPL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000006">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF48">
        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 14 16" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 16 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989421" description="Peroxidase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="17">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="110"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH99572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="327" mass="35521" checksum="783AF61DB726BE02" modified="2016-04-13" version="1">MASKITLMPLQFVCLIIVVVMMHGSEAQQQPLVKGLSWKYYESSCPKLESVVRKQLEKGCDGSVLLDGSASGPVDSEKTAPPNLSLRGFDIIEDLRRRVHKQCGAGSVSCSDITAIAARDAIVLTGGPEYSVPLGRRDGVSFATRDATLANLPSPFVPTETLLTTLAPRNFDATDAVALSGAHTIGVAHCPSFTRRLYPTQDATMDQTFAGNLKGVCPDANTNATTFMDIRSPNVFDNKYYVDLMNKQGLLTSDQDLYTDTRTRAIVTSFAVNQTLFFEKFVNVMVKMGQMEVLTGAQGEIRNNCSVRNSNDVLISSVVEGDNIESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZC0</accession>
    <name>A0A103XZC0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003423">
        <property type="protein sequence ID" value="KVH99665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZC0"/>
    <dbReference type="STRING" id="59895.A0A103XZC0"/>
    <dbReference type="Gramene" id="KVH99665">
        <property type="protein sequence ID" value="KVH99665"/>
        <property type="gene ID" value="Ccrd_022101"/>
    </dbReference>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="18475" checksum="E4BFE8EE25DDCF19" modified="2016-04-13" version="1">MIGAGKMKQYANVLDKPLSKGRQEVSLSAFAYLFSELVQYNQTQVDNIGDLERRLEDAGYAVGARVLELLCHREKGNRRETRLLGILSFIHSTVWKVLFGKVADSLEKGTEHEDEYMISEKELLGVLDNAGFPAVVTAHFVPVEGQQRPRTTILIKYYEEKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZG6</accession>
    <name>A0A103XZG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003416">
        <property type="protein sequence ID" value="KVH99738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XZG6"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF46">
        <property type="entry name" value="ENOLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="6">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="20346" checksum="E3E529819450F11F" modified="2016-04-13" version="1">MNMRISWFPLIFLSLQKSRKKRSRAFQYRNSKSWMHEKGGCYWNGCVASEFYDNKDXTCCLNFKEENDDVSQKISDDSLKNVYLLSFYYHSLDPFDQDDWEHYAKMTTEIGEQLQDASYGYGYDLFVTNPKCVDKAIKEKTCNALLMRVVQLLETPYAKFELKRFASFMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y090</accession>
    <name>A0A103Y090_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_021632</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y090"/>
    <dbReference type="Gramene" id="KVI00143">
        <property type="protein sequence ID" value="KVI00143"/>
        <property type="gene ID" value="Ccrd_021632"/>
    </dbReference>
    <dbReference type="OMA" id="TEENEIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000590">
        <property type="entry name" value="PR5-like receptor kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119254" description="non-specific serine/threonine protein kinase" evidence="16">
        <location>
            <begin position="32"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="117"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="574"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI00143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="978" mass="109926" checksum="803F1B04349CB766" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y100</accession>
    <name>A0A103Y100_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003381">
        <property type="protein sequence ID" value="KVI00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y100"/>
    <dbReference type="Gramene" id="KVI00529">
        <property type="protein sequence ID" value="KVI00529"/>
        <property type="gene ID" value="Ccrd_021217"/>
    </dbReference>
    <dbReference type="OMA" id="NFMAFLH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001644">
        <property type="entry name" value="ABC transporter G family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF79">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="38"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="604" mass="67871" checksum="EBE64B095A78DA0B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y193</accession>
    <name>A0A103Y193_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003359">
        <property type="protein sequence ID" value="KVI00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y193"/>
    <dbReference type="Gramene" id="KVI00679">
        <property type="protein sequence ID" value="KVI00679"/>
        <property type="gene ID" value="Ccrd_021076"/>
    </dbReference>
    <dbReference type="OMA" id="CAEYGEN"/>
    <dbReference type="OrthoDB" id="4573at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35106">
        <property type="entry name" value="BNAA07G25190D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35106:SF4">
        <property type="entry name" value="OS09G0485800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16261" checksum="F60A540678588054" modified="2016-04-13" version="1">MALAFNISQNHLFSYAQTTRFRSPCINGRQPRRLRISNLKKGCLRCNTSYQDKDNSPNACSFHGHANGDKGLFALAPPHQGIDGEWSDGSGVIVYKWNDKTDRPNTGRANWKKRWSCCGEYDENAPPCQRGWHVSYDDGFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3E1</accession>
    <name>A0A103Y3E1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002683">
        <property type="protein sequence ID" value="KVI01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3E1"/>
    <dbReference type="STRING" id="59895.A0A103Y3E1"/>
    <dbReference type="Gramene" id="KVI01793">
        <property type="protein sequence ID" value="KVI01793"/>
        <property type="gene ID" value="Ccrd_019920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.40">
        <property type="entry name" value="Protein of unknown function DUF3067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021420">
        <property type="entry name" value="DUF3067"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35126:SF1">
        <property type="entry name" value="DUF3067 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35126">
        <property type="entry name" value="SLR0598 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11267">
        <property type="entry name" value="DUF3067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12482" checksum="839DE43B93969A4A" modified="2016-04-13" version="1">MKRKKKGGKRRGLREKGSLVTMHYGVALGSSMFPLLYDAHYVGLQKRIQVNWTIVFPRRSYDAQLIKKRSFPLTEEEYLLRLDDVANTLKCWGLVSHIRNSLEKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3F8</accession>
    <name>A0A103Y3F8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_019895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002682">
        <property type="protein sequence ID" value="KVI01812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3F8"/>
    <dbReference type="STRING" id="59895.A0A103Y3F8"/>
    <dbReference type="Gramene" id="KVI01812">
        <property type="protein sequence ID" value="KVI01812"/>
        <property type="gene ID" value="Ccrd_019895"/>
    </dbReference>
    <dbReference type="OMA" id="NAPLMHL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02079">
        <property type="entry name" value="P-type_ATPase_HM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000071">
        <property type="entry name" value="Copper-transporting ATPase PAA1 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000047">
        <property type="entry name" value="Copper-transporting ATPase PAA1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF22">
        <property type="entry name" value="COPPER-TRANSPORTING ATPASE PAA1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI01812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="856" mass="89411" checksum="30446D7D30524CA4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5V1</accession>
    <name>A0A103Y5V1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_018610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002554">
        <property type="protein sequence ID" value="KVI03097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5V1"/>
    <dbReference type="STRING" id="59895.A0A103Y5V1"/>
    <dbReference type="Gramene" id="KVI03097">
        <property type="protein sequence ID" value="KVI03097"/>
        <property type="gene ID" value="Ccrd_018610"/>
    </dbReference>
    <dbReference type="OMA" id="VPHSPIE"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000043">
        <property type="entry name" value="Cytochrome P450 99A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF9">
        <property type="entry name" value="PREMNASPIRODIENE OXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI03097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="496" mass="56235" checksum="4BC1549725CD0E38" modified="2016-04-13" version="1">MEMTIVIGLALAVLVFFLFKFLTPSKTKKNLLPQPWRIPILGHMHHLIGTIPHRGVTELARKYGPLMHLQLGEVSTIVVSSPRWAKEILTTYDITFADRPETLTGEIVAYHNTDIVFSPYGEHWRHLRKICTLELLNTKKVKSFQSLREEECWSLVNEIKASGSGKPIDLSKCISILIARIVSRATFGKGIKDEVGFREIVRETVQLTGGFDIADIFPSKKVLHHLSGKRAKLTKIHNKLATLINNIISDHPGSQLSSSQESLLDVLLRHKDDAEFPLTSDTVKAVIFDMFGAGTDTSHVTIEWAISELIKCPRAMEKLQVKLREAIKGKERIQEEDIQDLMYLKNVIKETLRLHPPLPLLIPRECREPCVIDGYDIPKKTKLLVNVFAINRDPEYWKDPESFIPERFENSPINIMGSEYEYLPFGGGRRRCPGASMGLANIELPLANLLCYFNWKLPDGASHEELDMTELFGAAIQRKTRLVLVPMFQEIVDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6X2</accession>
    <name>A0A103Y6X2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002337">
        <property type="protein sequence ID" value="KVI03624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6X2"/>
    <dbReference type="STRING" id="59895.A0A103Y6X2"/>
    <dbReference type="Gramene" id="KVI03624">
        <property type="protein sequence ID" value="KVI03624"/>
        <property type="gene ID" value="Ccrd_018086"/>
    </dbReference>
    <dbReference type="OMA" id="ERSRTIH"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000007">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044841">
        <property type="entry name" value="LUX/BOA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31442">
        <property type="entry name" value="HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31442:SF21">
        <property type="entry name" value="TRANSCRIPTION FACTOR BOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="35953" checksum="F00FC1733F591599" modified="2016-04-13" version="1">MGEEVRITEYDVRGGGGGGGGGGGGGGGGGEDDDRVFEWEAGLPNVDDLTPLSQSLISAELLSAFSITPQPYRSMIDVNRASQNTLSNMRGALEKQSSTKYNSFKSFSDDKGYDEMVVEGEETADHGSDTRKLRRVDSGGDGGGAGEEAESALLADDSSARTSKRPRLVWTPQLHKRFVDVVAHLGVKNAVPKTIMQLMNVEGLTRENVASHLQKYRLYLKRMQGLSTQGPSSSDYLFASTPIPQNLQESGGGNGHRYAPGTTPVPYPAHMVPMPYPSPQMVPNSAVGDGGAYHHGYESHSYPYNMTMQQRDWSGNKFASVSAYQHRTTPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6X8</accession>
    <name>A0A103Y6X8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002336">
        <property type="protein sequence ID" value="KVI03637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6X8"/>
    <dbReference type="Gramene" id="KVI03637">
        <property type="protein sequence ID" value="KVI03637"/>
        <property type="gene ID" value="Ccrd_018062"/>
    </dbReference>
    <dbReference type="OMA" id="EYWQKQS"/>
    <dbReference type="OrthoDB" id="1733797at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33738">
        <property type="entry name" value="EMB|CAB82975.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33738:SF8">
        <property type="entry name" value="OS05G0454500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="18938" checksum="0AA67EF7EBC295A3" modified="2016-04-13" version="1">MENKNQSTSFSPPPPPHRSSSSSSFTAELFGDNNSQPSSTGVFASIFPPPSMVLARNPNCSQFTGATQKETSESQVWTTTHVTSAENVAKNTASANSSIMNMERRSIFQERVEPSPLSSSLYYGGQEDMYVCSSSDPTSQSYPKFKKMEGKDDPNHLHSASRGNWWQGSLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAT8</accession>
    <name>A0A103YAT8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dual specificity phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001863">
        <property type="protein sequence ID" value="KVI05680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAT8"/>
    <dbReference type="STRING" id="59895.A0A103YAT8"/>
    <dbReference type="Gramene" id="KVI05680">
        <property type="protein sequence ID" value="KVI05680"/>
        <property type="gene ID" value="Ccrd_015987"/>
    </dbReference>
    <dbReference type="OMA" id="CRNGITH"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381:SF2">
        <property type="entry name" value="MAP KINASE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381">
        <property type="entry name" value="MKPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI05680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="52594" checksum="47A81279D440486C" modified="2016-04-13" version="1">MLVEEDNTTPLPPPPPVAAGGDDRKTYSRSVSWAIAGISPVKPNPKIPKSLWLKARSCLPPLSVSRPKADEWPKAGSDDLGIWPNIAATPRSVSKPAPLPVNVDRSRFEFKKDKLAYFDKECSRIIDHVFLGSDSVAKNREVLCRNGITHVLNCVGFVCPEYFKKDFVYRTLWIRDSPNEDITSILYDVFDYFEDVREEKGRIFVHCCQGVSRSSSLVIAYLMWSEGWSFEESFRRVKAARGVTNPNMGFACQLLQCQKRVHAVPVSPDSALRMFRIAPYSSYSPLHLVPKLLTEPNANALDSRGAFIVHVPNNVYMWVGKSCVSLMFESASLAAARVIRYEKAIGPVLRIIEGEEPADFWWAISSVKEHEMEVRGGLGERRVVDYDLDFEIFDRATNGGVVPPLAITSNHHEMCLPARQSGWERLRKRSINGVVKELVTMDRSHKELESSSDLFSFLVKRFKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB47</accession>
    <name>A0A103YB47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin repeat-like-containing domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB47"/>
    <dbReference type="STRING" id="59895.A0A103YB47"/>
    <dbReference type="Gramene" id="KVI05841">
        <property type="protein sequence ID" value="KVI05841"/>
        <property type="gene ID" value="Ccrd_015850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34360">
        <property type="entry name" value="OS08G0519400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34360:SF1">
        <property type="entry name" value="OS08G0519400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119554" evidence="4">
        <location>
            <begin position="26"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="713"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI05841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="870" mass="98574" checksum="F29C16850A3A9AEA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBH3</accession>
    <name>A0A103YBH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001854">
        <property type="protein sequence ID" value="KVI06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBH3"/>
    <dbReference type="STRING" id="59895.A0A103YBH3"/>
    <dbReference type="Gramene" id="KVI06035">
        <property type="protein sequence ID" value="KVI06035"/>
        <property type="gene ID" value="Ccrd_015622"/>
    </dbReference>
    <dbReference type="OMA" id="STHCEGS"/>
    <dbReference type="OrthoDB" id="1935281at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18914">
        <property type="entry name" value="bHLH_AtORG2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="27889" checksum="544FE2229CBAB0FA" modified="2016-04-13" version="1">MFSFLQSDDLVFHEVGQQDLPVDLQDHVTMERNINYPAIKTRKRPGDLSTSKPNPVHADRVGDGKDDAQRKLIHKELERQRRKDMAKLCSSLRSLLPLEFIKGKRSTSDHMHQAVNYIKHMQENIKVQGAQRDQLIKKFAGMSARHLGSMNTNESLTNLLPNTVSVNPCNGGIEILINSCSIQDGFSLSGVLKALVEEGLNIISCTSTKVSERLFHTIQSEVNNEPAWTDPSALQQRLTAIANNHLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBJ4</accession>
    <name>A0A103YBJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBJ4"/>
    <dbReference type="Gramene" id="KVI06065">
        <property type="protein sequence ID" value="KVI06065"/>
        <property type="gene ID" value="Ccrd_015585"/>
    </dbReference>
    <dbReference type="OMA" id="PRWYLTK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000137">
        <property type="entry name" value="Probable inositol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF24">
        <property type="entry name" value="INOSITOL TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="534" mass="58288" checksum="7ECE3B80F07FA363" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBS6</accession>
    <name>A0A103YBS6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">EF-1 is composed of 4 subunits: alpha, beta (1B-alpha=beta'), delta (1B-beta), and gamma (1B-gamma).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001845">
        <property type="protein sequence ID" value="KVI06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBS6"/>
    <dbReference type="STRING" id="59895.A0A103YBS6"/>
    <dbReference type="Gramene" id="KVI06187">
        <property type="protein sequence ID" value="KVI06187"/>
        <property type="gene ID" value="Ccrd_015454"/>
    </dbReference>
    <dbReference type="OMA" id="MPSQADM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000006">
        <property type="entry name" value="Elongation factor 1-delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="152"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="241" mass="26257" checksum="4628410CFA40C69F" modified="2016-04-13" version="1">MAPTFYVGSEAGLKKLDEYLLSRSYITGYQASKDDLTVHAAFTKSPSPQYVNVSRWFNHIESLLRISLVILNDFASSSGVSAEGSGVTVEGSASFPEEAIATPPVAETKAAADEDDDSDVDLFGEETEEEKKAAEDRAAAVKASGKKKESGKSSVLLDVKPWDDETDMKKLEEAVRSVHLDGLLWGASKLVPVGYGIKKLQIMMTIVDDLVSVDTLIEERLTEEPINEYVQSCDIVAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC27</accession>
    <name>A0A103YC27_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001837">
        <property type="protein sequence ID" value="KVI06321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC27"/>
    <dbReference type="STRING" id="59895.A0A103YC27"/>
    <dbReference type="Gramene" id="KVI06321">
        <property type="protein sequence ID" value="KVI06321"/>
        <property type="gene ID" value="Ccrd_015334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI06321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="102" mass="11809" checksum="014E92698566CDF5" modified="2016-04-13" version="1" fragment="single">MFLTRVFGRTLLAAAKSETSVAGAAAAYTVRTGHNPLEEFFEADRNPEEEKPLEAFELHVKSWDDLHKLWYVLLKEKNMLMTQRQMLHAQNLPFPNPERLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCF4</accession>
    <name>A0A103YCF4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001799">
        <property type="protein sequence ID" value="KVI06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YCF4"/>
    <dbReference type="Gramene" id="KVI06547">
        <property type="protein sequence ID" value="KVI06547"/>
        <property type="gene ID" value="Ccrd_015107"/>
    </dbReference>
    <dbReference type="OMA" id="GDFHEKQ"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000009">
        <property type="entry name" value="Auxilin-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF70">
        <property type="entry name" value="DNAJ DOMAIN, CHAPERONE J-DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="939"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1443" mass="159629" checksum="85D2CF459EFBE6F7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCZ3</accession>
    <name>A0A103YCZ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_014826</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type IV zinc-finger family. Class C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001593">
        <property type="protein sequence ID" value="KVI06819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCZ3"/>
    <dbReference type="STRING" id="59895.A0A103YCZ3"/>
    <dbReference type="Gramene" id="KVI06819">
        <property type="protein sequence ID" value="KVI06819"/>
        <property type="gene ID" value="Ccrd_014826"/>
    </dbReference>
    <dbReference type="OMA" id="IDNAHIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045280">
        <property type="entry name" value="TIFY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125:SF20">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tify" evidence="17">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="16">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI06819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="307" mass="34019" checksum="0178BB7B0CC8F00F" modified="2016-04-13" version="1">MYGKSSMSEFGEIPPEEVPSHPGGVRNGVDSMDDRNVSYGLEDVDGGSDGICDFEGIDGVVYSDLAIMPRGDAGDQLTLSYCGQVYVFDNVTTDKYPRLFVEVYLISDDNVPVQKVFLHLGGCEFPVGQQGAESAYQNPRDLDYPGRCSDPRRAASLSRFRQKRKERCFEKKIRYNVRQEVARRMNRKKGQFVTSQNSKESAPWNTGEAEGAEQDEIPVTTTCAHCGTCSMDTPMMRRGPAGPRTLCNACGLFWANRGTMRDLSKKSNDQSSSLAEQVYKCKDEYNGSNFGTTMPRCSNDAELGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGX9</accession>
    <name>A0A103YGX9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_012736</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Promotes hydrogen peroxide H(2)O(2) production and cell death.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with ABCG40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001080">
        <property type="protein sequence ID" value="KVI08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI08899">
        <property type="protein sequence ID" value="KVI08899"/>
        <property type="gene ID" value="Ccrd_012736"/>
    </dbReference>
    <dbReference type="OMA" id="LPIQMCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000103">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase IX.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000168">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase IX.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000985">
        <property type="entry name" value="Lectin_LegA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019825">
        <property type="entry name" value="Lectin_legB_Mn/Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00308">
        <property type="entry name" value="LECTIN_LEGUME_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00307">
        <property type="entry name" value="LECTIN_LEGUME_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0611">Plant defense</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="350"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="996"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1026"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVI08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1304" mass="144416" checksum="5768E10D9C43F8E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIE8</accession>
    <name>A0A103YIE8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="LEKV01001044">
        <property type="protein sequence ID" value="KVI09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIE8"/>
    <dbReference type="STRING" id="59895.A0A103YIE8"/>
    <dbReference type="Gramene" id="KVI09711">
        <property type="protein sequence ID" value="KVI09711"/>
        <property type="gene ID" value="Ccrd_011903"/>
    </dbReference>
    <dbReference type="OMA" id="HASAQNC"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000006">
        <property type="entry name" value="Adenosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="35326" checksum="74315B4FACD25C64" modified="2016-04-13" version="1">MAGYEGILLGMGNPLLDISAVVDEDFLKKYDVKPNNAILAEDKHLPMYDELAAKDNVEYIAGGATQNSIRVAQVINFFFPGLQWMLQIPGATSYMGCIGKDKYGEEMTKNSKSAGVNVHYYEDETKPTGTCAVCVVGGERSLIANLSAANCYKSEHLKRPENWALVEKAKYIYIAGFFLTVSTESIQLVAEHAAATNKIFTMNLSAPFICEFFKDAQEKALLYVDYVFGNETEARTFSKVHGWETDNVEEIAIKISQLPKASGTHKRITVITQGDAFVGGFLSQLVKEKPIEECVRAGCYASNVIIQRSGCTYPEKPDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ09</accession>
    <name>A0A103YJ09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chlorophyll A-B binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001031">
        <property type="protein sequence ID" value="KVI10024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ09"/>
    <dbReference type="STRING" id="59895.A0A103YJ09"/>
    <dbReference type="Gramene" id="KVI10024">
        <property type="protein sequence ID" value="KVI10024"/>
        <property type="gene ID" value="Ccrd_011580"/>
    </dbReference>
    <dbReference type="OMA" id="PWWAWMM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="238" mass="26692" checksum="581A1776FE01BE5E" modified="2016-04-13" version="1">MASIGINAAMQKACSSSHLTNKEPSLPRTTPSFRTKKTTTFVALNVEAQMALNTPEEQNHINNGVTIGDGAETSSVKFADERWKHGTWDLNMFVKSGTMDWDALIVAEARRRKFLELYPEEATNHDPVLFRSSIIPWWAWVTHSHLPEAELLNGRAAMIGFFMAYLVDVLTRLDVVGQSGNFICKIGLFATVMGVVLFRQTNSLQDLKNLADEATFYDKQWQASWQDQDSSDDTSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJH1</accession>
    <name>A0A103YJH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_011394</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable transcription activator that may act as growth regulators in response to water deficit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001026">
        <property type="protein sequence ID" value="KVI10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJH1"/>
    <dbReference type="STRING" id="59895.A0A103YJH1"/>
    <dbReference type="Gramene" id="KVI10209">
        <property type="protein sequence ID" value="KVI10209"/>
        <property type="gene ID" value="Ccrd_011394"/>
    </dbReference>
    <dbReference type="OMA" id="DENIMEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19093">
        <property type="entry name" value="AKR_AtPLR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000293">
        <property type="entry name" value="Homeobox-leucine zipper protein ATHB-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF5">
        <property type="entry name" value="PYRIDOXAL REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="498" mass="56506" checksum="B99FAAEE923F9AD7" modified="2016-04-13" version="1">MLGDAQVLKKKNKNKNKNNNNNNNNNNRRFSDEQIKSLESLFKMENKLEPRKKLEMARELGLHPRQVAIWFQNRRARWKSKQVEQDYTTLKADYDSLSDRFESLKNEKHALLQQLRNLCNQLKEPHEGSKLDLESGSENGDTNLELNSSRPLEQDMAIYSDEDDLRKHKQKQELDENIMEMEEAQEIVKLGPMTVSPMGFGTWAWGNQLLWGYQESMDTELQQIFNLAIDNGINLFDTADSYGTGKLNGQSEKLLGRFIGAFEESSGQAKIRDNVVIATKFAAYPWRLTPNQFVNACRSSLDRLQIEQIGIAQLHWSTANYAPLQERALWDGLVAMYEKGLVRAVGVSNYGPKQLIKIHDYLKARGVPLSSAQVQFSLLSMGEDQMEIKNVCDSLGIRVISYSPLGLGMLTGKYTSSNLPRGPRGKSIPQVAINWCICKGTIPIPGVKSVKQAEENLGALGWKLRGNELDELEYGASQSSGKMIQNVFQTRWYDISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLA9</accession>
    <name>A0A103YLA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000797">
        <property type="protein sequence ID" value="KVI11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLA9"/>
    <dbReference type="STRING" id="59895.A0A103YLA9"/>
    <dbReference type="Gramene" id="KVI11211">
        <property type="protein sequence ID" value="KVI11211"/>
        <property type="gene ID" value="Ccrd_010381"/>
    </dbReference>
    <dbReference type="OMA" id="HEWGLMK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF389">
        <property type="entry name" value="EXOSTOSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="7">
        <location>
            <begin position="92"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="45507" checksum="368CE1513B7C80B8" modified="2016-04-13" version="1">MDAKICSEQQRGCWLPWLIIISVFAISIFPTDSTSIRSQKQESNLQKIEAGLAHARAAIKKATNQSSEDPDYVPSGSAYWNPNSFHRSYLEMEKRFKIYVYEEGDPPIFHTAPCYGILGLEGIFINDMEISRFRTKDPQKAHVYFLPFSIITLINYVYIVGSHDWSPMYDTVRDYITVINHKYPHWNRSQGADHFMLACHDWGPSISKSVPYLFKNSIRALCNANTSEGFKLSRDVSIPEIYLPHGTTNGLLGGPSPSKRTILVFFSGGVHGYIREVLLKHWENKTEDGVKIQKYLPKGDDYYQQDNYAKPFSDVLNWDTFSVDIPTSQIPQLKDILMAIPQRKYLRLQKNGAQVRKHFVVNLPPKRYDVFHMILHSIWLRRLDTHIRDINDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLJ4</accession>
    <name>A0A103YLJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000457">
        <property type="protein sequence ID" value="KVI11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLJ4"/>
    <dbReference type="Gramene" id="KVI11288">
        <property type="protein sequence ID" value="KVI11288"/>
        <property type="gene ID" value="Ccrd_010303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="42" mass="4965" checksum="197E22942284743F" modified="2016-04-13" version="1">MPLELGGMWRIFRMVVWLFASFSISRCFVKGMHTCTSQLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLQ4</accession>
    <name>A0A103YLQ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_010251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01000326">
        <property type="protein sequence ID" value="KVI11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLQ4"/>
    <dbReference type="STRING" id="59895.A0A103YLQ4"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF67">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="420" mass="47209" checksum="30F8CA5652EBDFB3" modified="2016-04-13" version="1">MAIAAAVVIVPIGVLFFVSGLIVNLIQALIFVIVRPFSKSIFRRINRMVAELLWLELVWIVDWWAGVKVNLYTDPETLRMMGMLYTAFIIVTLLRVKNLLLLTCCTIFSPNPVLFPGKEHALVIANHKSDIDWLIGWVFAQRSGCLGSTLAVMKKSSKFLPVIGWSMWFSEYLFLERSWAKDESTLKSGLQSLKDYPQPFWLALFVEGTRFTKAKLLAAQEYASSMGLPVPRNVLIPRTKGFVTSVSQMRSFVPAIIDMTVAIPKDSTPPTMLRLFKGQSSVVSLLDLKFWLCKDEIHVKVTRHSMKDLPESDEAVAQWCKDKFIVKDDVLDQHKIADAFPDSELVVVSWACLLVFGTFKFLQWSNLLSSWKGLTFAAVGLATVTILMQILIQFSQAEHSTPAKVAPVLSSNGTVREKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMF7</accession>
    <name>A0A103YMF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GUN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000029">
        <property type="protein sequence ID" value="KVI11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMF7"/>
    <dbReference type="STRING" id="59895.A0A103YMF7"/>
    <dbReference type="Gramene" id="KVI11870">
        <property type="protein sequence ID" value="KVI11870"/>
        <property type="gene ID" value="Ccrd_009718"/>
    </dbReference>
    <dbReference type="OMA" id="EFVWELN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046906">
        <property type="term" value="F:tetrapyrrole binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010019">
        <property type="term" value="P:chloroplast-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16383">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1770:FF:000001">
        <property type="entry name" value="Tetrapyrrole-binding protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1770">
        <property type="entry name" value="Gun4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008629">
        <property type="entry name" value="GUN4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037215">
        <property type="entry name" value="GUN4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34800">
        <property type="entry name" value="TETRAPYRROLE-BINDING PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34800:SF1">
        <property type="entry name" value="TETRAPYRROLE-BINDING PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05419">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140869">
        <property type="entry name" value="GUN4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GUN4-like" evidence="1">
        <location>
            <begin position="86"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="263" mass="30007" checksum="B93C43E10765A9CC" modified="2016-04-13" version="1">MKLSVTFRLGLKKKYNDNQANMLNSYIHGHQFSPISPPLGRRQSLPLSFTIQSNNANNPTLSISISISISSAVKTFSLPSSTSSSVQSTSFDLLQRLLSTNDFREADNETRRLLIGLAGEAAQKRGYIFFSEVQFIPQVYLQTIDQLWRNHSSNKFGYSVQKRLWEKSNKDFTAFFIKVGWMKKLDTKEVLQYNYRAFPDEFVWELNDETPEGHLPLTNALRGIQLLKCILSHPAFADAIEEDEREKLQQALGKGVVIPDYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118GG61</accession>
    <name>A0A118GG61_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008862">
        <property type="protein sequence ID" value="KVF92774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118GG61"/>
    <dbReference type="Gramene" id="KVF92774">
        <property type="protein sequence ID" value="KVF92774"/>
        <property type="gene ID" value="Ccrd_026617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF92774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="34" mass="3790" checksum="9D6120108596AE3C" modified="2016-04-13" version="1">MDTIVLLPSFLKLFREAKGHSNSTKQSCSSLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118HTX3</accession>
    <name>A0A118HTX3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytolysin/lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007807">
        <property type="protein sequence ID" value="KVG67535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118HTX3"/>
    <dbReference type="Gramene" id="KVG67535">
        <property type="protein sequence ID" value="KVG67535"/>
        <property type="gene ID" value="Ccrd_026276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053085">
        <property type="entry name" value="Jasmonate-induced_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049065">
        <property type="entry name" value="Nakanori"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36482:SF7">
        <property type="entry name" value="OS04G0308500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36482">
        <property type="entry name" value="OSJNBA0024J22.15 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21230">
        <property type="entry name" value="Nakanori"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG67535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="502" mass="54837" checksum="2789E236B640E43C" modified="2016-04-13" version="1">MAATAVRVFGKPITHGTRTQRALAAKNYQNADGKLDQVLRVSNQSLKAAAGVGNAATVSTTFGRVYNATGETVTYVTAYDWEGNVSGTYPVNIQNGQWAVFEHAGTRGPNRQGSVGALVYGIKDTSEFMISWNNPWKNSRGNSNTAYCEMNDPGYFENCDWDEILEKLMASGTESQTSLEATAVRVFGKPITHGTRTQRALAAKNYQNADGKLDQVLRVSNQSLKAAAXVGNAATLSTTFGRVYNATGETQSDYRIHDFIEYLPRIESLKESQNSDIXPCHPYPKPHLQSFLLLQYQLNTSMAATAVRVFGKPITHGTRTQRALAAKNNQNADGKLDQALQLSNQFRKVAAGGGNVATVNTTLGMVYNATGETVTYVTSHDWEGNASRGYKVIILNGQWGVFEHDGNRQGSVGAVVYGIKDCSEFMISWNNPWKNCGGNSNTAYCEMNDPGYFENCDWDEIHEKLMASGTESQTSWRGYSTKVSIQAGGNIASVTAFFYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118INI9</accession>
    <name>A0A118INI9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006980">
        <property type="protein sequence ID" value="KVH27281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118INI9"/>
    <dbReference type="STRING" id="59895.A0A118INI9"/>
    <dbReference type="Gramene" id="KVH27281">
        <property type="protein sequence ID" value="KVH27281"/>
        <property type="gene ID" value="Ccrd_025847"/>
    </dbReference>
    <dbReference type="OMA" id="SKGQNSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF218">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH27281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="728" mass="81185" checksum="4A6FA354DE91427B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTV6</accession>
    <name>A0A118JTV6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4079 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005081">
        <property type="protein sequence ID" value="KVH91076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTV6"/>
    <dbReference type="STRING" id="59895.A0A118JTV6"/>
    <dbReference type="Gramene" id="KVH91076">
        <property type="protein sequence ID" value="KVH91076"/>
        <property type="gene ID" value="Ccrd_006909"/>
    </dbReference>
    <dbReference type="OMA" id="PMQKGSE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34679:SF2">
        <property type="entry name" value="OS02G0122500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19633" checksum="8D50D542A919AA1A" modified="2016-04-13" version="1">MGGLFAYTLYAGYLGWQWRRVRTLQDEINDLKKQEKPVAVTPEGTPLQPTTPSPVQAKIQQLSEERKELIKGQYREKHFNAGSILLAFGVFESIGGGVNTYLRTGKLFPGPHLYAGAAITVLWAAAAALVPPMQKGSETARNLHIALNVLNVLLFIWQIPTGWDIVLKVFEFTKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUC0</accession>
    <name>A0A118JUC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004824">
        <property type="protein sequence ID" value="KVH92317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUC0"/>
    <dbReference type="STRING" id="59895.A0A118JUC0"/>
    <dbReference type="Gramene" id="KVH92317">
        <property type="protein sequence ID" value="KVH92317"/>
        <property type="gene ID" value="Ccrd_005641"/>
    </dbReference>
    <dbReference type="OMA" id="HCVRCKV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1077">
        <property type="entry name" value="METHYLTRANSFERASE PMT27-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="827" mass="93558" checksum="21C9DFAB7ED1590F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX50</accession>
    <name>A0A118JX50_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase A22B, signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_002524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004390">
        <property type="protein sequence ID" value="KVH95424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX50"/>
    <dbReference type="Gramene" id="KVH95424">
        <property type="protein sequence ID" value="KVH95424"/>
        <property type="gene ID" value="Ccrd_002524"/>
    </dbReference>
    <dbReference type="OMA" id="KNANQTR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000007">
        <property type="entry name" value="Signal peptide peptidase-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF75">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159756" evidence="13">
        <location>
            <begin position="27"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH95424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="519" mass="57815" checksum="A4EB18A9E1FCA302" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXD2</accession>
    <name>A0A118JXD2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photosystem II Pbs27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_002039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Thylakoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXD2"/>
    <dbReference type="STRING" id="59895.A0A118JXD2"/>
    <dbReference type="Gramene" id="KVH95892">
        <property type="protein sequence ID" value="KVH95892"/>
        <property type="gene ID" value="Ccrd_002039"/>
    </dbReference>
    <dbReference type="OMA" id="GDYRQDT"/>
    <dbReference type="OrthoDB" id="419533at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009543">
        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010206">
        <property type="term" value="P:photosystem II repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.810:FF:000001">
        <property type="entry name" value="Photosystem II lipoprotein Psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.810">
        <property type="entry name" value="Photosystem II Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01481">
        <property type="entry name" value="PSII_Psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025585">
        <property type="entry name" value="PSII_Psb27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038450">
        <property type="entry name" value="PSII_Psb27_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041:SF1">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13326">
        <property type="entry name" value="PSII_Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0793">Thylakoid</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18715" checksum="CB72A76D2B831C1B" modified="2016-04-13" version="1">MALITPTTSAPKPLLPPIRSKHTTPSLSTTTATANTATTHRRNFLSLTAIVTLSSPLLVIPAALAASDDEYVKETQEVISKVRNTINMDKTDPNIATAVAELRETSNSWVAKYRREKALLGRISFRDIYSALNAVSGHYVNFGPTSPIPAKRKTRILEEMESAEKALLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXH1</accession>
    <name>A0A118JXH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003855">
        <property type="protein sequence ID" value="KVH97119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXH1"/>
    <dbReference type="STRING" id="59895.A0A118JXH1"/>
    <dbReference type="Gramene" id="KVH97119">
        <property type="protein sequence ID" value="KVH97119"/>
        <property type="gene ID" value="Ccrd_000777"/>
    </dbReference>
    <dbReference type="OMA" id="EGRITKM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37745">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37745:SF3">
        <property type="entry name" value="TRANSPOSASE, PTTA_EN_SPM, PLANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="604" mass="68852" checksum="0CB7CF71929458A1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXR4</accession>
    <name>A0A118JXR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_001592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004334">
        <property type="protein sequence ID" value="KVH96324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXR4"/>
    <dbReference type="STRING" id="59895.A0A118JXR4"/>
    <dbReference type="Gramene" id="KVH96324">
        <property type="protein sequence ID" value="KVH96324"/>
        <property type="gene ID" value="Ccrd_001592"/>
    </dbReference>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000459">
        <property type="entry name" value="ARM repeat superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH96324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="907" mass="100431" checksum="CC2C9618FE3DA9D5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY63</accession>
    <name>A0A118JY63_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003807">
        <property type="protein sequence ID" value="KVH98167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JY63"/>
    <dbReference type="Gramene" id="KVH98167">
        <property type="protein sequence ID" value="KVH98167"/>
        <property type="gene ID" value="Ccrd_023610"/>
    </dbReference>
    <dbReference type="OMA" id="FFNGHAG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF16">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="502" mass="57082" checksum="3E46CA95177FE87D" modified="2016-04-13" version="1">MSSYLQFYLLSFLAFFFLILFIFKWVSFHFHAKKSFPPSPRKLPIIGNLHQLGSSPHRSLQALSQKHGPLMLMHFGSVPVLVASSAEAAREIMKTHDLKFASRPKLNIPDIVVYGSNDITFSRYGEYWRQVKSIAVVHLLNNTRVQSFQHVRAKEVAVLIEMIKKDGGSVTDMSELVFWLVNNIVCKVALGRTYRGLKFRNLXERFVQVLGAISVGSYIPWLSWIDRLSGLEDKAHQVAKEXDAFFEGXXEEHINKRKGXDNVQSDEDQDFVDILLDVQRDNTTGFTLFNDTIKALILDVFVAGTDTTFATLIWSISELLRHPRVMKKLQLEVXEIAQGKPLILEKDLEKMEYLKATIKETLRMYPPLPLLIPRESRQDVELMGYDIPKGTQTIINAWAIGRDPTSWEEPDEFRPERFLNSSTDYKGVHFELIPFGAGRRGCPGIQYGVVIVQLALANIVYKFDLTLPNGVEDGDLDMSETCAITLHKSSSLMVKASPRFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYN4</accession>
    <name>A0A118JYN4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYN4"/>
    <dbReference type="STRING" id="59895.A0A118JYN4"/>
    <dbReference type="Gramene" id="KVH97719">
        <property type="protein sequence ID" value="KVH97719"/>
        <property type="gene ID" value="Ccrd_000183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sugar phosphate transporter" evidence="5">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="5">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="30990" checksum="654FB3DC1F91E025" modified="2016-04-13" version="1">MASLMSHLSLLPAKPSNISNFSSRISPTLALRTSQPVFLSARNSSEKRPVEFSGKQLRYCGWNQLLRPRCSVEIPVVKAAASADGGDREIEGFVSVVHLLVGVTYCLISWSIGLPKRAPINKDLLGVLTPVAACHALGHVMSNVSFAAVAVSFTHTIKGVSMASLTELSFNWLGFTSAMISNISFTYRSIYSKKAMIEGPKLMRYGFSDAIAKVGMVKFVSDLFWIGMFYHLYNQVATNTLERVAPLTHAVGNVLKRVFVIGFSIIVFEDCTKGGLEDACLQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K038</accession>
    <name>A0A118K038_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003209">
        <property type="protein sequence ID" value="KVI00858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K038"/>
    <dbReference type="Gramene" id="KVI00858">
        <property type="protein sequence ID" value="KVI00858"/>
        <property type="gene ID" value="Ccrd_020887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="44" mass="5046" checksum="A4A2601DAB0BC9E8" modified="2016-04-13" version="1">MSDFGLLKLNPRFYFDKCSYCFVVEGLRKSSQIRNRVVGTGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0U9</accession>
    <name>A0A118K0U9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_020504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0U9"/>
    <dbReference type="Gramene" id="KVI01216">
        <property type="protein sequence ID" value="KVI01216"/>
        <property type="gene ID" value="Ccrd_020504"/>
    </dbReference>
    <dbReference type="OMA" id="NYDNHKQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001234">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000126">
        <property type="entry name" value="Putative ABC transporter B family member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136:SF2">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="153"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="383"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="694"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI01216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="933" mass="102356" checksum="9F68671FF70CDB64" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1A9</accession>
    <name>A0A118K1A9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GHMP kinase, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1A9"/>
    <dbReference type="STRING" id="59895.A0A118K1A9"/>
    <dbReference type="Gramene" id="KVI02508">
        <property type="protein sequence ID" value="KVI02508"/>
        <property type="gene ID" value="Ccrd_019252"/>
    </dbReference>
    <dbReference type="OMA" id="NHMDELG"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053034">
        <property type="entry name" value="Glucuronokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710:SF1">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="3">
        <location>
            <begin position="101"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="4">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI02508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="378" mass="41381" checksum="FD4FFF497B1AF876" modified="2016-04-13" version="1">MEGNGSPAVATAAEAEIIEHKAYARIGLLGNPSDVYYGRTISLNISNFWASVRLEPSSDLVIVPHPTHDLVKFSSLSHLVNRLENEGYYGGVRLLMATCKVFNKYCKEQGIDLHNNNFSLSYDTNIPRQTGLSGSSAIVCAAFSCLLDFYDVRDKIAVEMRPQLILNAEKELGIVAGLQDRVAQVYGGLVYMDFNKESMDKYGHGNYTQLDTSLLPPLHLIYAENPSDSGKVSSIQLLILYFYVPPCLLCIFRQRWLDGDEFIISSMEEVANLALEGKSALLEKDYAKLATLMNQNFDLRSDAALGALNIEMVEVARRVGAASKFTGSGGAVVVFCPDGPSQVECLENACKKAGFDIAPVKVVPSLLSKIDIKTLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1B1</accession>
    <name>A0A118K1B1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1B1"/>
    <dbReference type="STRING" id="59895.A0A118K1B1"/>
    <dbReference type="Gramene" id="KVI02507">
        <property type="protein sequence ID" value="KVI02507"/>
        <property type="gene ID" value="Ccrd_019253"/>
    </dbReference>
    <dbReference type="OMA" id="FNLPVWG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35737">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35737:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="23466" checksum="DFEA6800D5A56DA4" modified="2016-04-13" version="1" fragment="single">APFFQISFHHFRFNPFVGFQKATRFCNPLSTVPANSMELDDEDWELINDDGFVYKRLRLHPTTSAAHPPAADPAVVERNRNERKKTILAKLKTRYQKEIHDWELLSNTLQALQNRTKTQPPPSMSPDLSISQSPEHSSDSTFRDLTETLLIQVEAQEASINEISNLCDVAEALCNAQEQLLKQPFVYLPIWESSPRKLITSLCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1E3</accession>
    <name>A0A118K1E3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1E3"/>
    <dbReference type="STRING" id="59895.A0A118K1E3"/>
    <dbReference type="Gramene" id="KVI02341">
        <property type="protein sequence ID" value="KVI02341"/>
        <property type="gene ID" value="Ccrd_019329"/>
    </dbReference>
    <dbReference type="OMA" id="DIWGGHG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35296">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35296:SF8">
        <property type="entry name" value="SMALL AUXIN-UP RNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15919" checksum="54C63688CFC31036" modified="2016-04-13" version="1">MNKINLMLRRCKTISSQLVKTSSYSTLIRSKSNTDHGSESSPPTFMWNTTVVSVYTTGEIEPHQIVFVGSTRKRYVIASKYLTHPLVNALIQKSTSNDNNNVVSVINCEVVLFDHLLWMLQNSDFNLTSDSLDELADLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2N6</accession>
    <name>A0A118K2N6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001957">
        <property type="protein sequence ID" value="KVI04623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2N6"/>
    <dbReference type="STRING" id="59895.A0A118K2N6"/>
    <dbReference type="Gramene" id="KVI04623">
        <property type="protein sequence ID" value="KVI04623"/>
        <property type="gene ID" value="Ccrd_017046"/>
    </dbReference>
    <dbReference type="OMA" id="KANWAPS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="309" mass="35035" checksum="952C8633D11D7389" modified="2016-04-13" version="1">MAVSHIFLKANWAPSFDQNHVLSTQRNADYAWRIVLMLGALPALLTYYWRMKMPYTAIIEGNAKQAASDMGRRHGRHLIGTMSTWFLLDIAFYSQNLTQKDIFPVMGLTKKARQVNALEEMFEISRAMFVIAMFGTFPGYWFTVAFIEKLGRFNIQLMGFFKMSVFMFIIGIKYEDLATRDNRWLFSALYGLTFFFANFRPNSTTFVLPAELFPTRVRSTCHAMSAAAGKAGAMVGAFGIQTYTLHGEKSKIKKEMIILAVTNMLGFFCTFLVTETKGRSLEEISGEDGSKDKAEAQMSNRGSRQSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K301</accession>
    <name>A0A118K301_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K301"/>
    <dbReference type="STRING" id="59895.A0A118K301"/>
    <dbReference type="Gramene" id="KVI05178">
        <property type="protein sequence ID" value="KVI05178"/>
        <property type="gene ID" value="Ccrd_016512"/>
    </dbReference>
    <dbReference type="OMA" id="SYKFRQA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF11">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN DDB_G0270170-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="620" mass="67754" checksum="447F13C732B08DCF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3K2</accession>
    <name>A0A118K3K2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L30, ferredoxin-like fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3K2"/>
    <dbReference type="STRING" id="59895.A0A118K3K2"/>
    <dbReference type="Gramene" id="KVI06062">
        <property type="protein sequence ID" value="KVI06062"/>
        <property type="gene ID" value="Ccrd_015580"/>
    </dbReference>
    <dbReference type="OMA" id="IEEHMGK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF36">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="28707" checksum="7421F7BE3703B4C2" modified="2016-04-13" version="1">MADEEPKPLNYVSEIVLKKRKSNEDWANRRKEQLEQRESDLIKMKHRGKRPIKASMFPQSKLLFVIRIQGSVTDDDICFLATVHVKFKSDMHPQTRKLLYSLRLRRIFSGVFVKANNRILEILQKVEPYVTYGYPNLKSMNELIYKKGLAKVNKQIFPLTDNNIIEQVWRFIYDRALSEHGIICIEDIVKEIANVGPHFKEVCNFLCPFSLNEPQKALQGKKRPFRDGGDSGNREDQINELIGKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K439</accession>
    <name>A0A118K439_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001553">
        <property type="protein sequence ID" value="KVI06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K439"/>
    <dbReference type="STRING" id="59895.A0A118K439"/>
    <dbReference type="Gramene" id="KVI06887">
        <property type="protein sequence ID" value="KVI06887"/>
        <property type="gene ID" value="Ccrd_014758"/>
    </dbReference>
    <dbReference type="OMA" id="FGDMLEW"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000132">
        <property type="entry name" value="caffeoylshikimate esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="57"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="324" mass="35666" checksum="0D4F94DAE6A19687" modified="2016-04-13" version="1">MVHPITEANETSPFGILTPEQFYAHHAVTHSHDHITNPRGLKLFTQSWTPLPPTKIIGIICVVHGYTGESSWFVQLTSVHLAKAGFAVCAIDHQGHGFSEGLPLHIPDINPVVDDCISFFNSFREKHAPSLPSFLYSESLGGAIALLITLRRNGAGKPYDGVVLNGAMCGISDKYKPPWPLEHFLSVAAALIPTWRVVPTRGSIPDVSFKVEWKRKLAMASPRRSVARPRASTAQELLRICREMQSKFAEVEIPFLIVHGGDDVVCDPSCAEDLYRRAASKDKTMKIYPGMWHQLVGEPDADVEVVFGDVVDWLKSRAIGGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K472</accession>
    <name>A0A118K472_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001531">
        <property type="protein sequence ID" value="KVI07022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K472"/>
    <dbReference type="STRING" id="59895.A0A118K472"/>
    <dbReference type="Gramene" id="KVI07022">
        <property type="protein sequence ID" value="KVI07022"/>
        <property type="gene ID" value="Ccrd_014625"/>
    </dbReference>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="276"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="576" mass="63315" checksum="202C9D6586369A19" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K644</accession>
    <name>A0A118K644_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K644"/>
    <dbReference type="Gramene" id="KVI10081">
        <property type="protein sequence ID" value="KVI10081"/>
        <property type="gene ID" value="Ccrd_011544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF14">
        <property type="entry name" value="LIPASE YOR059C ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="220" mass="25072" checksum="F8238DC6D9E528B5" modified="2016-04-13" version="1" fragment="single">MECKMRNSDVCSSEEVARREDVFSCPQSDVSSADHLVVMVNGILGSSADWKFAAEQFVNTIPDKVLVHRSKRNAAIQTLDGVDVMGERLSLEVPFLFGVSVLEKAAVLVIHWIFGRTGRHLFLTDDEKGEPPLLKRMLEDFGDCHFMSALRSFHRRVAYSNVGCDHIVGWRTSSIRRNMDLPKWEESVNEKYPHIVHEELCKAYDDKQVFTNNDIINDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L2</accession>
    <name>A0A118K6L2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000996">
        <property type="protein sequence ID" value="KVI10815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L2"/>
    <dbReference type="Gramene" id="KVI10815">
        <property type="protein sequence ID" value="KVI10815"/>
        <property type="gene ID" value="Ccrd_010783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="13340" checksum="201B777A6251EB80" modified="2016-04-13" version="1">MPARIGHYDSSLHIIAIPFHVKEALHYLASWFFQNALRCDSDLTFKGIRVVSTEQLSGSLSFQPWNFPMRYVDIGIPANNKGQENPDASQNCRTKSRRGLFTIKTSLYEDIEHQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAK0</accession>
    <name>A0A124SAK0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005874">
        <property type="protein sequence ID" value="KVH87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SAK0"/>
    <dbReference type="Gramene" id="KVH87745">
        <property type="protein sequence ID" value="KVH87745"/>
        <property type="gene ID" value="Ccrd_024969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="27383" checksum="07160323C8D38C5F" modified="2016-04-13" version="1">MNPQVRQNKIGKVRPLLSSIAPTFAHSSPNFSRLTSLEQEEHHILHPSSSLSLPCSPPSSLLSLVLSSSCSPPSYQHRRLLSSQSRFSSFQFFYSIQSSPGSILQLCSHKPSSIFNGLQPNCFCNPSLFTDSVALGTPSIDLGGSFSTQGNRFQVPFMGCYISSSPVNFAAKRQMCVPRSCLRHGRKLVGXSLIGGIKETQEMIDFAAKHNITAAIXLIXIDYINTAMEXLAKXDVRYRFVIDVVNTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBD7</accession>
    <name>A0A124SBD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005107">
        <property type="protein sequence ID" value="KVH90307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SBD7"/>
    <dbReference type="Gramene" id="KVH90307">
        <property type="protein sequence ID" value="KVH90307"/>
        <property type="gene ID" value="Ccrd_007678"/>
    </dbReference>
    <dbReference type="OMA" id="NMPINES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF157">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1977"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2095"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2579"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="910"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1500"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1649"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1877"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2620"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2771"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1654"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2620"/>
            <end position="2645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2773"/>
            <end position="2798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2881" mass="315325" checksum="E4C0C4C5AEB5EE3E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC66</accession>
    <name>A0A124SC66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC66"/>
    <dbReference type="STRING" id="59895.A0A124SC66"/>
    <dbReference type="Gramene" id="KVH92827">
        <property type="protein sequence ID" value="KVH92827"/>
        <property type="gene ID" value="Ccrd_005127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="38031" checksum="DA594A6BA669FFF2" modified="2016-04-13" version="1">MNTLQPTLKPFQWNPHPNPKSKPTSTIKNQIDPPKPQSSAGKIKRLVLTKEGRTKFNISPDKDFYAYPRFVTHVDDNFIATLTDVYRKKLSPEFEILDLMSSWVSHLPEEVKFKKVVGHGLNPQELAKNPRLDYFVVKDLNQDQKFEFQNASFDAVLCTVSVQYLQQPEKVFSEVFRVLRPGGVFIVSFSNRLFYEKAIGAWREGTGFGRVQLVVQYFQCVEGFTEPEVVRKLADGAKPDGSAFGWIKGLLGLVSGSDPFYACEQKEKEEDEEAQVEEAEEASTKENLVLKSSSCRATHKGKFWGVFTILDDGRWWKTASTDLVHRCEQREHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCN6</accession>
    <name>A0A124SCN6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bax inhibitor 1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCN6"/>
    <dbReference type="STRING" id="59895.A0A124SCN6"/>
    <dbReference type="Gramene" id="KVH94357">
        <property type="protein sequence ID" value="KVH94357"/>
        <property type="gene ID" value="Ccrd_003582"/>
    </dbReference>
    <dbReference type="OMA" id="EFIWASV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF31">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="31428" checksum="33127757829C8C78" modified="2016-04-13" version="1">MMSQSQLPVRKADVESGTSRDLYPMMLESPELRWSFIRKVYSIVAIQLLLTVAVGAVVVSYRPIVTFLTTTTGGLACYILLIITPFITLCPLYYYHQRHPINYFLLAIFTASLAFAVGLTCAFTKDMLRFLFCVGKPINRSTLINRIDCSYCLTILIAGKVILEAAILTAVVVVSLTLFTFWAARRGYDFNFLGPFLFGALMVLFVFSLIQLFFPLGKTSTMIYGCLGAIIFCGYIVYDTDNLIKRYTYDEYIWAAISLYLDILNLFMSLLTILTGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDD2</accession>
    <name>A0A124SDD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004271">
        <property type="protein sequence ID" value="KVH96552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDD2"/>
    <dbReference type="STRING" id="59895.A0A124SDD2"/>
    <dbReference type="Gramene" id="KVH96552">
        <property type="protein sequence ID" value="KVH96552"/>
        <property type="gene ID" value="Ccrd_001361"/>
    </dbReference>
    <dbReference type="OMA" id="SSCCADR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF17">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36667" checksum="1C707C5FAAA2FEFF" modified="2016-04-13" version="1">MPKHLVPPPPPFSFLVTQQLMSEQTRSCPKAKYEPISLIMGSTFSIQDPQGVSATASIVPIFYNIVSMSEQIKQFETIYGNLTLVKGRHATKTLLARSMFAVSVGSNDLFGYFESRSTVDPVIFINSLMTAYGCHINVSIYIISNFYSQYDYREIELKDRHIVKALYNLGARKFGIIGVPPIGCCPSQRIHNGTGGCLEIENTFARAFHSALDALMKQLASKLPEMKYALGNSYEMTINVINQAQLFTKFYLICADFKSVDTACCGEGWLNAEKTCTPEANMCSNRDEYLFWDLYHPTQYAAELAAMTLYNGGPQFVTPINFAQLVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDP0</accession>
    <name>A0A124SDP0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Peroxidase</fullName>
            <ecNumber evidence="4 17">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_000351</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14 17">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="14 17">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 17"/>
    <dbReference type="EMBL" id="LEKV01003825">
        <property type="protein sequence ID" value="KVH97540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDP0"/>
    <dbReference type="STRING" id="59895.A0A124SDP0"/>
    <dbReference type="Gramene" id="KVH97540">
        <property type="protein sequence ID" value="KVH97540"/>
        <property type="gene ID" value="Ccrd_000351"/>
    </dbReference>
    <dbReference type="OMA" id="RMSEIEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000006">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF215">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 17 19" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="18">
        <location>
            <begin position="57"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="149"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH97540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="315" mass="33596" checksum="04F85C0406F6FC46" modified="2016-04-13" version="1">MQFSSQIRAKDLQLFVFFSSIDFNHIMGYQKPSGSVSVFVSVLILVLSLDCMPCNAQLSTTFYDDTCPNALAAINTVITDAVTTENRMAASIIRLHFHDCFVQGCDASILLDDTPSEKTTGANSGVRGYEVIDAAKAAVENICPGVVSCADVLAVAARDASVAELPTLITSFARKGLSEREMVALSGSHTIGQARCLTFRGRIYNNASNIDPIFAANLRANCPTTGGDGNLEPLDLVTPNRFDNNYFTNLEQRRGLLISDQTLFNGGSADSIVQGYIDNPASFASDFAAAMVAMGDIDPLTGSDGVIRTLCTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDS5</accession>
    <name>A0A124SDS5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate dehydrogenase (acetyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_000019</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of 2 alpha and 2 beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003816">
        <property type="protein sequence ID" value="KVH97867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDS5"/>
    <dbReference type="STRING" id="59895.A0A124SDS5"/>
    <dbReference type="Gramene" id="KVH97867">
        <property type="protein sequence ID" value="KVH97867"/>
        <property type="gene ID" value="Ccrd_000019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07307">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037488">
        <property type="entry name" value="At2g33490-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34119">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34119:SF1">
        <property type="entry name" value="OS04G0394700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176173" description="pyruvate dehydrogenase (acetyl-transferring)" evidence="14">
        <location>
            <begin position="24"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="813"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH97867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="976" mass="107712" checksum="F44DF0D084C615C4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEX2</accession>
    <name>A0A124SEX2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003089">
        <property type="protein sequence ID" value="KVI01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEX2"/>
    <dbReference type="Gramene" id="KVI01457">
        <property type="protein sequence ID" value="KVI01457"/>
        <property type="gene ID" value="Ccrd_020268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF66">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19014" checksum="3643D427B6A1C893" modified="2016-04-13" version="1">MFRDESACNTYNYGDSVYWDARYVHEASAGSFDWYQRYHALRPFVRKYIPISSRVLMVGCGNAGLVNINLVDCYIGMLLGYYCYSGHISDSELKLSFPIAPSLTELILFPSKSQFEEGLYPFEWLPFMSEDMVKDGYESIMNVDISCVAIEMMRRKYEHVPQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFI9</accession>
    <name>A0A124SFI9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nascent polypeptide-associated complex NAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May promote appropriate targeting of ribosome-nascent polypeptide complexes.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002355">
        <property type="protein sequence ID" value="KVI03392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFI9"/>
    <dbReference type="STRING" id="59895.A0A124SFI9"/>
    <dbReference type="Gramene" id="KVI03392">
        <property type="protein sequence ID" value="KVI03392"/>
        <property type="gene ID" value="Ccrd_018296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="14035" checksum="21A574C369C55311" modified="2016-04-13" version="1">MTAQTQEELLAAHLEQQKIEILFVISKPDVFKSPASDTYVIFGEAKIEDLSSQLQSQAAEQFKAPNLGNVVSEPEPTAMAQDDEDVDETGVEPKDIELVMTQAGVSRSKAVKALKAADGDIVSAIMELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGD5</accession>
    <name>A0A124SGD5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001853">
        <property type="protein sequence ID" value="KVI06047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGD5"/>
    <dbReference type="STRING" id="59895.A0A124SGD5"/>
    <dbReference type="Gramene" id="KVI06047">
        <property type="protein sequence ID" value="KVI06047"/>
        <property type="gene ID" value="Ccrd_015611"/>
    </dbReference>
    <dbReference type="OMA" id="AQQYNPF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31245:SF20">
        <property type="entry name" value="F18B13.13 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31245">
        <property type="entry name" value="UBIQUITIN SYSTEM COMPONENT CUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="25947" checksum="8D979B349A5F2C2F" modified="2016-04-13" version="1">MSAIVCGKRSFFEELPTSTGSVSPPVSKKLRCSSSNSPVRRSPFTNSPTASALIDQLRVVFPNTDKQLLEKALEESGNDLDSAIKSLNELYFGYMDGNSGHMALSNAASSEEYVTVEKSSANGNTPRSGAEWVELFVTEMMNATSENTAVKEQIEVLVRENSILKRAVAIQHERQKAYEESSQEVQQLKQMLSTYQEQLRTLEVNNYVLRMHLRQAQESNNCMPGRFHPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGW6</accession>
    <name>A0A124SGW6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_013982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001498">
        <property type="protein sequence ID" value="KVI07678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGW6"/>
    <dbReference type="Gramene" id="KVI07678">
        <property type="protein sequence ID" value="KVI07678"/>
        <property type="gene ID" value="Ccrd_013982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF102">
        <property type="entry name" value="TRANSCRIPTION FACTOR C2H2 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="187" mass="20446" checksum="B5C0B61B118A9C07" modified="2016-04-13" version="1">MSPRFRILGGLDSSTATPPQPTPDDDYENVNTEFIIFIGLAIILASLLCIIGLNAARCTWIRRFSDTVITGGIDHFSLPAAKLLRSIPKLTYSAESMAEKFSDCAICLAEFVVGEEIRVLPRCGHCFHVVCIDKWIGSHFTCPSCRQKLLKSTRCNLCADEVPVAGVTGIQFTTAGETSVTINRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI33</accession>
    <name>A0A124SI33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Coiled-coil domain containing protein 109, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_010127</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000118">
        <property type="protein sequence ID" value="KVI11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI33"/>
    <dbReference type="STRING" id="59895.A0A124SI33"/>
    <dbReference type="Gramene" id="KVI11458">
        <property type="protein sequence ID" value="KVI11458"/>
        <property type="gene ID" value="Ccrd_010127"/>
    </dbReference>
    <dbReference type="OMA" id="CPIRSSW"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="112"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="293" mass="32873" checksum="7D6FC19CE514CFFA" modified="2016-04-13" version="1">MWRSSFPLLKQGVTSTVGRCKPTSFGLTRTAFVESNNGLCGCLFSTSGGVGVGRSGNGNGGGSASVEEVNKMMRSVDVEAVKAKLGTGGNEVVRYSELLQACESMGVAKSAEEAKEIVKGLDDAGVIFIFRDKVYLHPHKVMDLVRRAVPLALMPEDDPEKEELKRLQAKQEEIDVLAHKQVRRILWGGLGLSIAQVSLFFRLTFWEFSWDVMEPITFFTTSSGLILGYAYFLFTSRDPSYQDLMKRLFLSRRRKLMKKHNFNVERLMELQKKCKSPLESGMMLETDDLLHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103K8K3</accession>
    <name>A0A103K8K3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01009385">
        <property type="protein sequence ID" value="KVF46405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103K8K3"/>
    <dbReference type="STRING" id="59895.A0A103K8K3"/>
    <dbReference type="Gramene" id="KVF46405">
        <property type="protein sequence ID" value="KVF46405"/>
        <property type="gene ID" value="Ccrd_026760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVF46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="18304" checksum="9C664D0A009DD883" modified="2016-04-13" version="1" fragment="single">LGSFVVYDLSHISLCDLVFLVYQSYPVIRIQGHSRSQVFTAYITAAVDFSLFALELYLTHKGCLDFIARRSRLVFLDTDAAGRALPRVIEILAAEHHWQKQRQKQDSEIAISYHCRSHLRINYREALQLVGNFCLEEELEEHWLHHDSLRDFDLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103PTH6</accession>
    <name>A0A103PTH6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008250">
        <property type="protein sequence ID" value="KVG36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103PTH6"/>
    <dbReference type="STRING" id="59895.A0A103PTH6"/>
    <dbReference type="Gramene" id="KVG36940">
        <property type="protein sequence ID" value="KVG36940"/>
        <property type="gene ID" value="Ccrd_026465"/>
    </dbReference>
    <dbReference type="OMA" id="MRNINDA"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000010">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase, basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007117216" evidence="5">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVG36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="36794" checksum="72B19037EDC977BA" modified="2016-04-13" version="1">MASKLILLGLLMNLLVFTDAQVGVCNGRVGDGLPSEQDVVTFYRSNGITRMRIYDPNQATLRALQGTNIELILDVPNDVLQSLNDQNAANTWVRNNIQNFPGVRFRYIAVGNEVDPNNESRRFANFVLSAMRNLHGAIRAAGLGNQIKVSTATYTGLIVNSFPPSNGAFNDNVRGFIEPIIRFLAANNLPVLANIYPYFGYLGDPNGNLPYALFTAPGTVVNDNGRLYSNLFTAMLDAHYAAQARVGGENVEIVVSESGWQSAGGRAAIVENAGTYNNNLIKYVKSTTGSPRKPGRTIETYIFAMFDENRKPGAETEKHFGLFSPNRQPKYQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Q3Q6</accession>
    <name>A0A103Q3Q6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008175">
        <property type="protein sequence ID" value="KVG42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Q3Q6"/>
    <dbReference type="STRING" id="59895.A0A103Q3Q6"/>
    <dbReference type="Gramene" id="KVG42317">
        <property type="protein sequence ID" value="KVG42317"/>
        <property type="gene ID" value="Ccrd_026427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9564" checksum="2352271B43A77620" modified="2016-04-13" version="1">MVKPAFAKRSVINHHEYLPGASIITSDAIGIEDDQVSTMEGRLIEFDYLVIATGDMGTGYVTKVEKLRQYEVGKFGCSAHSAFWHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UJ25</accession>
    <name>A0A103UJ25_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_025805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006907">
        <property type="protein sequence ID" value="KVH36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UJ25"/>
    <dbReference type="Gramene" id="KVH36545">
        <property type="protein sequence ID" value="KVH36545"/>
        <property type="gene ID" value="Ccrd_025805"/>
    </dbReference>
    <dbReference type="OMA" id="ACFLRMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000005">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF884">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE HOMOLOG 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="358" mass="40427" checksum="1588976B22AD907A" modified="2016-04-13" version="1">MVSNTPIESNYDRESELKAFDDSKSGVKGLVDAGLTKIPRFFHHPRPIINEPKSSTLQTQVDIPIIDLKETNARAEIVENVRYAAENWGFFQIINHGIPQRVLDEMIDGARGFHEMETEEKIKYYSRDYQKKFFYTSNFHLFTGDAASWNDTFLSVMAPQPPQPEELPPICRNIITEYSDQIMKLGFTLLELLSEALGLKPDHLKSLGCGQGLFVLGHYYPPCPEPELTFGANYHTDSGFLTIVLQDSLGGLQVLHQKQWVNVSPLPGALVLLTNDKFKSVHHRVLAQKGTPRISVAAFLRPFHEGIESIVYRPIKELVSEENPCVYKDASLDEFVRLRRNAEGLDGKSALAPFKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBG4</accession>
    <name>A0A103XBG4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_025067</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01005971">
        <property type="protein sequence ID" value="KVH87648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH87648">
        <property type="protein sequence ID" value="KVH87648"/>
        <property type="gene ID" value="Ccrd_025067"/>
    </dbReference>
    <dbReference type="OMA" id="FTEPANG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000537">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF3">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118659" description="Receptor-like serine/threonine-protein kinase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="21">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="22">
        <location>
            <begin position="341"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="517"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVH87648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="800" mass="90502" checksum="19BA1566A8D9D01A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBI1</accession>
    <name>A0A103XBI1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_025042</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements. Required for RNA silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RNA polymerase II, IV and V complexes. Interacts with NRPD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005936">
        <property type="protein sequence ID" value="KVH87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A103XBI1"/>
    <dbReference type="STRING" id="59895.A0A103XBI1"/>
    <dbReference type="Gramene" id="KVH87674">
        <property type="protein sequence ID" value="KVH87674"/>
        <property type="gene ID" value="Ccrd_025042"/>
    </dbReference>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000419">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="114" mass="13054" checksum="000614730D668181" modified="2016-04-13" version="1">MSTMKFCRECNNILYPKEDKDQKILLYACRNCDHQEVADNNCVYRNEIHHAVGERTQVLQDVAADPTLPRTKAVRCAQCGHGEAVFFQATARGEEGMTLFFVCCNPNCGHRWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC49</accession>
    <name>A0A103XC49_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005644">
        <property type="protein sequence ID" value="KVH87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC49"/>
    <dbReference type="Gramene" id="KVH87996">
        <property type="protein sequence ID" value="KVH87996"/>
        <property type="gene ID" value="Ccrd_024620"/>
    </dbReference>
    <dbReference type="OMA" id="KMPRISI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116:SF4">
        <property type="entry name" value="DNA GLYCOSYLASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116">
        <property type="entry name" value="OS04G0501200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="399" mass="44037" checksum="A2E66F3515C8AA3E" modified="2016-04-13" version="1">MCSSKSKLIQPIQVNSKATPAATMVSDINGRPVLQPATSNRVLARCSHKKSPSLPKSASTPPPPPPPPLHANQPEYCTNSSSERLFPSTPIKCTAQKSVIPVKKLKGVTSNNGGGHDHRSSDFISAAVISTNPNSLVKYSSAAIVDAPGSIAAVRRVQVAAIQVQRKMRIAHYGRSKSAKYDSCSKLTSYFDFNSLMNATTGFREEKRCSFITPTSDPIYVGYHDEEWGVPVHDDKLLFELLVLTGAQVGSDWTSVLRRRQKFREAFSEFEAEIVSKFTDKKITSISSCYGIEVGLIRGVVDNSNCILQIKKAFGSFDKYIWGFLNHKPIVTQYKLNQKMPVKSSKSEAISKDMVRRGFRQVSPTVIHSFMQAAGLTNDHLITCPRHLQCGRHPPFSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCG4</accession>
    <name>A0A103XCG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005538">
        <property type="protein sequence ID" value="KVH88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCG4"/>
    <dbReference type="STRING" id="59895.A0A103XCG4"/>
    <dbReference type="Gramene" id="KVH88172">
        <property type="protein sequence ID" value="KVH88172"/>
        <property type="gene ID" value="Ccrd_024440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="9312" checksum="F0E855DDD20870CC" modified="2016-04-13" version="1" fragment="single">FGFSDKPQPGYGFDYTEKEYHEQVDKLLDVLEVKSPFSLVVQDTETCNNEHLTASSPIPGLLQQLRFKFCNNFYNFFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDC4</accession>
    <name>A0A103XDC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005358">
        <property type="protein sequence ID" value="KVH88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDC4"/>
    <dbReference type="STRING" id="59895.A0A103XDC4"/>
    <dbReference type="Gramene" id="KVH88640">
        <property type="protein sequence ID" value="KVH88640"/>
        <property type="gene ID" value="Ccrd_026244"/>
    </dbReference>
    <dbReference type="OMA" id="PEMSHEV"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF52">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="18166" checksum="992257148D65D860" modified="2016-04-13" version="1">MARVLAVEQLNQLRDIFARFDMDSDGSLTYLELAALLRSLGLKLSGDQIYILFHNMDSNGNGAIEFEELVGAMSIDVKTEEILINQRQLHEAFRWFDREGNGFITPAQLAKSMAKLGQPLTYRELTAMLEEADIDGDGVINFREFTRVMAKSAADIFGIQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDK5</accession>
    <name>A0A103XDK5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005338">
        <property type="protein sequence ID" value="KVH88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH88786">
        <property type="protein sequence ID" value="KVH88786"/>
        <property type="gene ID" value="Ccrd_025708"/>
    </dbReference>
    <dbReference type="OMA" id="KCHASIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250:SF18">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="17108" checksum="A49420CCDF53D1C7" modified="2016-04-13" version="1" fragment="single">MADRRNWNIQEEDVLISILQDIVAAGGRSDNGCFRTGTYDQIVSKMREKIPGLNITSKHIQNKMKRLKDKYSAAYDMLNTSGFGWDDAHQCVTVDAQVLEEYLKKHPNKNYIXNKPFPQYERLKTIFGKDRATGSMAESAADALEHINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEK8</accession>
    <name>A0A103XEK8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSXT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005252">
        <property type="protein sequence ID" value="KVH89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEK8"/>
    <dbReference type="STRING" id="59895.A0A103XEK8"/>
    <dbReference type="Gramene" id="KVH89312">
        <property type="protein sequence ID" value="KVH89312"/>
        <property type="gene ID" value="Ccrd_008701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="20821" checksum="86E212D50F5F04F4" modified="2016-04-13" version="1">MKQPMIQNPMMSSSFPPTNITTDQIQKFLDENKQLILAIMNNQNLGKLAECAQYQALLQKNLMYLAAIADAQPPTPTPAPTPTPTISSQMTPVPHLGMQQQGGFYMQQQQHHPQAVMAHQPSGFPPQMAAMQFNSPQGIQAQMGGISGGPMHGEPTLRASAPTDVWRGGNSMQDGGGADGAKDGHGSAASGSEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEQ3</accession>
    <name>A0A103XEQ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_008635</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 20">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The LHC complex consists of chlorophyll a-b binding proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005224">
        <property type="protein sequence ID" value="KVH89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XEQ3"/>
    <dbReference type="Gramene" id="KVH89375">
        <property type="protein sequence ID" value="KVH89375"/>
        <property type="gene ID" value="Ccrd_008635"/>
    </dbReference>
    <dbReference type="OMA" id="GREAHGM"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000001">
        <property type="entry name" value="Chlorophyll a-b binding protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 19 20" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="6 20" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15 20" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 20" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="12 20" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="18 20" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="9 20" id="KW-0934">Plastid</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 20" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="28106" checksum="704C2844986C24C7" modified="2016-04-13" version="1">MAASTMALSSPFTGQVVKTAPSSSEVLGSGRVSMRKTAVKKVAPSGSPWYGPDRVKYLGPFSGEAPSYLTGEFPGDYGWDTAGLSADPETFAKNHELEVIHCRWAMLGALGCVFPELLARNGVKFGEAVWFKAGAQIFSEGGLDYLGNPXLVHAQSILAIWATQVILMGAVEGYRVAGGPLGEIVDPLYPGGSFDPLGLADDPEAFAELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPLENLADHLADPVANNAWSYATNFTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGD7</accession>
    <name>A0A103XGD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGD7"/>
    <dbReference type="STRING" id="59895.A0A103XGD7"/>
    <dbReference type="Gramene" id="KVH90275">
        <property type="protein sequence ID" value="KVH90275"/>
        <property type="gene ID" value="Ccrd_007737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040283">
        <property type="entry name" value="DDB_G0292058-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0292058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118760" evidence="2">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="322" mass="36330" checksum="65C246804A1921CC" modified="2016-04-13" version="1">MLKTIPYPFSFLLLFLALFLSSSNGESRFSISQSKPTSGNTGRGIYDLVDSWGRKRFLGDEEKNRNTSLVLAQQRTTRKDPLDKFKIYTGGWNIKDRHYWASVAFTAAPFLVVAATWLRNVSDDLAAAKKIAVAQVFLPVDVQADIDNIQTKLNVSATELSKRTKENKKYVESLQLGVVRMGFCDRNICVMWCVPLSPKVYSKFVCQVSASGVCTTAGRLTPDSFNQMSAGIELSYSLYLYGPFLVELQDCTFVRQTFTDISQDHCPGLCRYLNWIYIGLFMVSLAVMLSLVFWVILGRERRHRVYTKTVVSSSGRGGEKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHP7</accession>
    <name>A0A103XHP7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005086">
        <property type="protein sequence ID" value="KVH90976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XHP7"/>
    <dbReference type="Gramene" id="KVH90976">
        <property type="protein sequence ID" value="KVH90976"/>
        <property type="gene ID" value="Ccrd_007009"/>
    </dbReference>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="940"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="1789"/>
            <end position="2004"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2664" mass="301741" checksum="22201148A3B2B16D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIH9</accession>
    <name>A0A103XIH9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coactivator CBP, KIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005037">
        <property type="protein sequence ID" value="KVH91385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIH9"/>
    <dbReference type="STRING" id="59895.A0A103XIH9"/>
    <dbReference type="Gramene" id="KVH91385">
        <property type="protein sequence ID" value="KVH91385"/>
        <property type="gene ID" value="Ccrd_006591"/>
    </dbReference>
    <dbReference type="OMA" id="SMQANAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044661">
        <property type="entry name" value="MED15a/b/c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33137">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33137:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="6">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1117" mass="121041" checksum="B5ED595BB7E8B53C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJG6</accession>
    <name>A0A103XJG6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_006065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004898">
        <property type="protein sequence ID" value="KVH91921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJG6"/>
    <dbReference type="STRING" id="59895.A0A103XJG6"/>
    <dbReference type="Gramene" id="KVH91921">
        <property type="protein sequence ID" value="KVH91921"/>
        <property type="gene ID" value="Ccrd_006065"/>
    </dbReference>
    <dbReference type="OMA" id="YICGVED"/>
    <dbReference type="OrthoDB" id="687943at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009610">
        <property type="term" value="P:response to symbiotic fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04216">
        <property type="entry name" value="Phytocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000067">
        <property type="entry name" value="Cupredoxin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF504">
        <property type="entry name" value="PHYTOCYANIN DOMAIN, CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118854" evidence="12">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="13">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH91921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="17520" checksum="285C0C1738B4A736" modified="2016-04-13" version="1">MTTSHLIIVVIATLGVLASSISAKEYIVGDESGWTLDFDYQTWAKDKVFFVGDTLVFNYASGAHTVVKVNGTGFQQCIVSPAIGTLTSGRDVVPLQTAGRKWYICGVGKHCESKNMKLVITVLPQTMVPAPSPMATSTSNKLATPTCYRFVAILFGSLLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK51</accession>
    <name>A0A103XK51_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear fragile X mental retardation-interacting protein 1, conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004840">
        <property type="protein sequence ID" value="KVH92168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK51"/>
    <dbReference type="STRING" id="59895.A0A103XK51"/>
    <dbReference type="Gramene" id="KVH92168">
        <property type="protein sequence ID" value="KVH92168"/>
        <property type="gene ID" value="Ccrd_005799"/>
    </dbReference>
    <dbReference type="OMA" id="NSFFKHC"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="627" mass="70049" checksum="99CB4BB3DDFE7595" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLS8</accession>
    <name>A0A103XLS8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004795">
        <property type="protein sequence ID" value="KVH93093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLS8"/>
    <dbReference type="STRING" id="59895.A0A103XLS8"/>
    <dbReference type="Gramene" id="KVH93093">
        <property type="protein sequence ID" value="KVH93093"/>
        <property type="gene ID" value="Ccrd_004863"/>
    </dbReference>
    <dbReference type="OMA" id="TYNEREG"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16987">
        <property type="entry name" value="ANTH_N_AP180_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000005">
        <property type="entry name" value="putative clathrin assembly protein At2g25430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF75">
        <property type="entry name" value="CLATHRIN COAT ASSEMBLY PROTEIN AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="10">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="588" mass="66140" checksum="4B2129F9724B6F8E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMH0</accession>
    <name>A0A103XMH0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_004560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type IV zinc-finger family. Class C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004774">
        <property type="protein sequence ID" value="KVH93398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMH0"/>
    <dbReference type="STRING" id="59895.A0A103XMH0"/>
    <dbReference type="Gramene" id="KVH93398">
        <property type="protein sequence ID" value="KVH93398"/>
        <property type="gene ID" value="Ccrd_004560"/>
    </dbReference>
    <dbReference type="OMA" id="SECKAND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045280">
        <property type="entry name" value="TIFY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125:SF24">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46125">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00979">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tify" evidence="17">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="16">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH93398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="44210" checksum="09A30E14A3B11278" modified="2016-04-13" version="1">MGTNDCLRWKHHIRLGHQIEPGEILGPDSRIPIGDTIRAQVPTICSLSAFFPPLDVKKQGNLNDQHHRQASIYETVNLQPVNLHHHQQQGISINNNDNQHHIVEDVVVQEDDDVAGAEEESIDNPSQIRYDHHNPHHHHHQHHNIQNNGSLEGGMEEMSVQPHALYVPDSEIQPVSAGGAGGGGGADQLTLSFQGEVYVFDAVSPEKVQAVLLLLGGYEVPTGAPTMGMPPQNQRGLTEFPGRSSQPQRAASLSRFREKRKERCFDKKIRYSVRKEVALRMQRKKGQFTSSKAISDEAGSASSDWNGGPGQDEETTCRHCGISSKSTPMMRRGPSGPRTLCNACGLKWANKGVLRDLNKVSASGAPDPTGKAIEQSDGEANDTNAVNVNAIMVSNGGDNSAVTGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ28</accession>
    <name>A0A103XQ28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like calcium-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_003144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004525">
        <property type="protein sequence ID" value="KVH94788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH94788">
        <property type="protein sequence ID" value="KVH94788"/>
        <property type="gene ID" value="Ccrd_003144"/>
    </dbReference>
    <dbReference type="OMA" id="ANISSTX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119004" evidence="7">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH94788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="38574" checksum="05B10B577DA17B8F" modified="2016-04-13" version="1">MHLLFTLVLCTLPLTMVFGGNHQISTTIASGNIAKQDCQTQCGNVTVSYPFGIGVDCALDGSFNFFCNSTEEPPKLIYGENIEVYSISDSEINISTSIGYTCYNKEGIITDTFDAWTSIPSTDPFTFSRKNKFTVIGCDDFANISSTXFSSGCWGTCNEANEVPXGYCSGIGCCQTSIPKGLKDYTVTLNSFDDHKRVQSFNPCGXAFLGEEDSFKFLGAEDXYNYTEFYDRTLSKVPIVLDWVIGSNRSCKEATECKGNSSCKDAEXGGYHCICNEGYEGNPYLDPGCQDIDECKDKSHCYGNCINIQGSYNCTCWPGYTGDAMTADGCRYIAKKSKILAFVLSLGNSSCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ61</accession>
    <name>A0A103XQ61_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_003066</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004514">
        <property type="protein sequence ID" value="KVH94866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ61"/>
    <dbReference type="STRING" id="59895.A0A103XQ61"/>
    <dbReference type="Gramene" id="KVH94866">
        <property type="protein sequence ID" value="KVH94866"/>
        <property type="gene ID" value="Ccrd_003066"/>
    </dbReference>
    <dbReference type="OMA" id="ISMIVHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000005">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH94866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="488" mass="54879" checksum="6510EA0F8A28D915" modified="2016-04-13" version="1">MREILHIQGGQCGNQIGAKFWEVVCAEHGIDSTGRYQGDSDLQLERINVYYNEASCGRFVPRAVLMDLEPGTMDSLRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRTMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSTVCDIPPTGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEYYEEEEEEEVRDLDKKMKKERVMKVLEMAITCDLDGLLARKGHDTGARTSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRI0</accession>
    <name>A0A103XRI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactokinase galactose-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRI0"/>
    <dbReference type="STRING" id="59895.A0A103XRI0"/>
    <dbReference type="Gramene" id="KVH95558">
        <property type="protein sequence ID" value="KVH95558"/>
        <property type="gene ID" value="Ccrd_002329"/>
    </dbReference>
    <dbReference type="OMA" id="HYQCGVE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000037">
        <property type="entry name" value="L-arabinokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000008">
        <property type="entry name" value="L-arabinokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000140">
        <property type="entry name" value="L-arabinokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053205">
        <property type="entry name" value="GHMP_kinase_L-arabinokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134:SF2">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134">
        <property type="entry name" value="SLR1395 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="4">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="3">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="776" mass="84971" checksum="57144879E6CC448E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUC4</accession>
    <name>A0A103XUC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003884">
        <property type="protein sequence ID" value="KVH97024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUC4"/>
    <dbReference type="STRING" id="59895.A0A103XUC4"/>
    <dbReference type="Gramene" id="KVH97024">
        <property type="protein sequence ID" value="KVH97024"/>
        <property type="gene ID" value="Ccrd_000883"/>
    </dbReference>
    <dbReference type="OMA" id="ATSKWMI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF5">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="69" mass="7460" checksum="E093ADC18CB0281A" modified="2016-04-13" version="1">MDNTTSWLTESAKLEFNWRIVLATLIEFLGSACGTVGCVGSGGGIFVPMLTLIVGFDTKYVAALYKCMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV71</accession>
    <name>A0A103XV71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV71"/>
    <dbReference type="STRING" id="59895.A0A103XV71"/>
    <dbReference type="Gramene" id="KVH97504">
        <property type="protein sequence ID" value="KVH97504"/>
        <property type="gene ID" value="Ccrd_000393"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724561at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055186">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF188">
        <property type="entry name" value="ZINC FINGER PROTEIN GAI-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22996">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="494" mass="53338" checksum="1AB7B8F248EA40E1" modified="2016-04-13" version="1">MVSGSSSSPLMFLGTVGVDHMNPMTNSRQDSNFVLPTALPPAQLHHHLIAPADQTMIHGPSCKTDPETEVAIAVSPNTLLADGNRFICDICYKGFPRQQNLQLHGRVHNLPFKLRARRGVVQRKVYLCPVPTCAHHNRARALSDFGGLKKHYLRKHSNEKKHECNSCSKKYAVESDLKAHLKICGKKKYNCSCGAPFSRHSHFAFHQAFCDGQEQEDASKHPPTSDVGNSSVGSTSNNNSSLIGSPTLDLPTLNMGENNNNNSSSNDNSSSVIGSTTPPLDHESLVTPDPSLGLNLIENTAAFFSPSPTPQNQLQGKFGTGFYTNLLMNTNPYNNLDLNSIAFMGEGGIYGSEEAGANSFTGGGIMLDHSSSLHSTSVVYKATLREQLSTPQLFLNDDVLGFTSRNNKSNMVQGHISSSSSGVGGFMMPQEHSAFGSKYLGIANNIGYNTIPNELQNPVNGNDVGSAIFNHDVGGSYMQGGYYGFGDGNNHHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW34</accession>
    <name>A0A103XW34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF630 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW34"/>
    <dbReference type="STRING" id="59895.A0A103XW34"/>
    <dbReference type="Gramene" id="KVH97968">
        <property type="protein sequence ID" value="KVH97968"/>
        <property type="gene ID" value="Ccrd_023784"/>
    </dbReference>
    <dbReference type="OMA" id="ENDQTHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF59">
        <property type="entry name" value="PROTEIN, PUTATIVE_ 48652-45869-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="254"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46790" checksum="6D150A05E425E80B" modified="2016-04-13" version="1">MGCSESKINNVETVNRCKQRKAFMQRSISARNAFAATHFAYAAALKNAGAALSDYAQGELWFLDQFHSTSATSSTTTSSHPPPPQHLRYDSLPPPPPPPPPHPDSSDFKPRSNLIVNEVDEAEDHNIKHSRYRSSNGGRARSGIVKSNLKYEIADDRNLDRAAPPPPENDEISSWDFFSTLMKDMPGPSLAEDDDKRSRNDGRPKIPRKILENQREHDGGGAIRTGGGYGKAVEESEVKPPPSAMKGGVQNVNLLQVFKELADCFMKASESVHEVSKILEANRVMRVITWNKSFKGPQIADDSKDDLTSKENDQTHATVLDKMLGWEKKLYDEVKLPSDAQQACEDVKYEYKKKIDSMNKLRKRSASRDSLERNEAMISHLHTRCIVNMQSTDSTVSEINRLRDEQLYPKLVQLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX59</accession>
    <name>A0A103XX59_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003794">
        <property type="protein sequence ID" value="KVH98504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX59"/>
    <dbReference type="STRING" id="59895.A0A103XX59"/>
    <dbReference type="Gramene" id="KVH98504">
        <property type="protein sequence ID" value="KVH98504"/>
        <property type="gene ID" value="Ccrd_023279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="12703" checksum="66D87A1345F8BA79" modified="2016-04-13" version="1" fragment="single">MEAVRLTMADQESVFHYQLEELHRIYRKQVELMEELKGTAIGRTQEQLESIRKRVKKLKLELENEMVNFNELIEVEIQVGKDMDAPATPEITNSTMAQGKQVLQEEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ67</accession>
    <name>A0A103XZ67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003437">
        <property type="protein sequence ID" value="KVH99593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ67"/>
    <dbReference type="STRING" id="59895.A0A103XZ67"/>
    <dbReference type="Gramene" id="KVH99593">
        <property type="protein sequence ID" value="KVH99593"/>
        <property type="gene ID" value="Ccrd_022171"/>
    </dbReference>
    <dbReference type="OMA" id="WKKNILM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33237:SF4">
        <property type="entry name" value="F14O23.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33237">
        <property type="entry name" value="F2P16.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13472" checksum="E121407C3BFBBD0F" modified="2016-04-13" version="1">MARPLPSHPLTEGASHLCLAIGSVFFCALTLFMCAGHSRKWVHHLKACYSYSYEEPVIQLNGFQDEEEEEEEEEEESVWQKNILMGGKCQLPDFSGVIIYDSQGNIAPTKPRLLALTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0A1</accession>
    <name>A0A103Y0A1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0A1"/>
    <dbReference type="STRING" id="59895.A0A103Y0A1"/>
    <dbReference type="Gramene" id="KVI00155">
        <property type="protein sequence ID" value="KVI00155"/>
        <property type="gene ID" value="Ccrd_021592"/>
    </dbReference>
    <dbReference type="OMA" id="HHKSETI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48000">
        <property type="entry name" value="OS09G0431300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48000:SF46">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="256" mass="29076" checksum="E672D19C4B56CCF7" modified="2016-04-13" version="1">MKLITLRWLNYLRPNIKHGEFSEDEDRIICSLYANIGSSYFNPNSSSFNCNYNPNFLNVSNTINSHLPATATTLIHDHINVTDLFSPLPPLSNPNLTGVISNNNYYSGFQDDHCQSMINNRPVAEYYYYYPDQVKERMLMFGGGDQVSTDCSSSEGGGGGCMSQIKDHHRMIKQEEQFGVQGFEDQMHSLMTDEHKGYFKNHVSPLHNNLEEVKQLNNSSSSIISRYMQMDDDENKTTHIISDGCYVMIDGGTTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0S7</accession>
    <name>A0A103Y0S7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_021410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0S7"/>
    <dbReference type="STRING" id="59895.A0A103Y0S7"/>
    <dbReference type="Gramene" id="KVI00434">
        <property type="protein sequence ID" value="KVI00434"/>
        <property type="gene ID" value="Ccrd_021410"/>
    </dbReference>
    <dbReference type="OMA" id="NTCTNTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000001">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000528">
        <property type="entry name" value="Plant_nsLTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00382">
        <property type="entry name" value="LIPIDTRNSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119277" evidence="12">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI00434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="16564" checksum="C4BF6FF07D226743" modified="2016-04-13" version="1">MAQHQTTLILAITMAVLYGTAMAQSSGCTSVLISMSPCLNYISGNSSTPSSGCCTQLASVVRSQPECLCQVLNGGGSSMGININQTQALELPKACNVQTPPTTSSPTNSPSGTTPSSSGNPSGTDTETNTVPSTDNGSSDATSTRFASIPIVFSLLVVAYTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1E1</accession>
    <name>A0A103Y1E1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003288">
        <property type="protein sequence ID" value="KVI00747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1E1"/>
    <dbReference type="STRING" id="59895.A0A103Y1E1"/>
    <dbReference type="Gramene" id="KVI00747">
        <property type="protein sequence ID" value="KVI00747"/>
        <property type="gene ID" value="Ccrd_021000"/>
    </dbReference>
    <dbReference type="OMA" id="FCDGYCQ"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000108">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF862">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="169"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="520" mass="56994" checksum="DEE34C6C3DC61268" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1Z5</accession>
    <name>A0A103Y1Z5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_020669</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01003135">
        <property type="protein sequence ID" value="KVI01055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1Z5"/>
    <dbReference type="Gramene" id="KVI01055">
        <property type="protein sequence ID" value="KVI01055"/>
        <property type="gene ID" value="Ccrd_020669"/>
    </dbReference>
    <dbReference type="OMA" id="FRIRWDG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000005">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF242">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="15">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="16">
        <location>
            <begin position="365"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="514"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI01055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="840" mass="94585" checksum="F3F7E52F79064952" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2F9</accession>
    <name>A0A103Y2F9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-[acyl-carrier-protein] hydrolase</fullName>
            <ecNumber evidence="11">3.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_020449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an essential role in chain termination during de novo fatty acid synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Plastid</location>
            <location evidence="1 11">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01003121">
        <property type="protein sequence ID" value="KVI01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2F9"/>
    <dbReference type="STRING" id="59895.A0A103Y2F9"/>
    <dbReference type="Gramene" id="KVI01282">
        <property type="protein sequence ID" value="KVI01282"/>
        <property type="gene ID" value="Ccrd_020449"/>
    </dbReference>
    <dbReference type="OMA" id="QTTLHCE"/>
    <dbReference type="OrthoDB" id="618395at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000014">
        <property type="entry name" value="Acyl-[acyl-carrier-protein] hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021113">
        <property type="entry name" value="Acyl-ACP-thioesterase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049427">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase_NHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="OLEOYL-ACYL CARRIER PROTEIN THIOESTERASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727:SF2">
        <property type="entry name" value="PALMITOYL-ACYL CARRIER PROTEIN THIOESTERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20791">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12590">
        <property type="entry name" value="Acyl-thio_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-ACP-thioesterase N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-ACP thioesterase N-terminal hotdog" evidence="13">
        <location>
            <begin position="142"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-ACP thioesterase-like C-terminal" evidence="15">
        <location>
            <begin position="303"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="422" mass="46523" checksum="313BE30D34229AE2" modified="2016-04-13" version="1">MVATAATASLFPVSSPQPDSGAKNSGKHGGGLGSVDVRGIKTKSGSSGSLQVKANAQAPAKVNGSRIGVMDGLKIDDNPSSAAPRTFINQLPDWSMLLAAITTIFLAAEKQWMMLEWKTKRPDMLSDMDPFGLGRIVEDGFIFRQNFSIRSYEIGADRTASVETLMNHLQETALNHVKNAGLLGDGFGSTPEMCKKNLFWVVTKMQVLVDRYPTWGDVVQVDTWVAASGKNGMRRDWLIRDWKTGEILTRASSNWVMMNKVTRRLSKIPDEVRAEIEQYFVNTPPIIDDDNRKLPKLDENTADHVLDGLTPKWSDLDVNLHVNNVKYVGWILESAPQPVVENYELASITLEYRRECMKDSVLQSLTSMVGNGGGGMADVDCQHLLRLAGGGSEIVKGRTKWRPKYANRFRSSSMGQLATESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2M5</accession>
    <name>A0A103Y2M5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-lysine N-methyltransferase, SET2, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003110">
        <property type="protein sequence ID" value="KVI01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2M5"/>
    <dbReference type="STRING" id="59895.A0A103Y2M5"/>
    <dbReference type="Gramene" id="KVI01375">
        <property type="protein sequence ID" value="KVI01375"/>
        <property type="gene ID" value="Ccrd_020356"/>
    </dbReference>
    <dbReference type="OMA" id="KCHCGAP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19175">
        <property type="entry name" value="SET_ASHR3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047893">
        <property type="entry name" value="ASHR3-like_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025787">
        <property type="entry name" value="Hist-Lys_N-MeTrfase_SET2_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51578">
        <property type="entry name" value="SAM_MT43_SET2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="269"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="49122" checksum="E7784E9187FED7AF" modified="2016-04-13" version="1">MIIATMPDLGNLVSMSSLTLSRCTNNTSRPNCDLGDPGSAKEAETPFLMQDQSSRQKCVKIKKSVESKSTDDYLGDWVAKNVELGIPESKLFLPFLVGAPKLAECLVCESVIYPGEEVACVVRDCKGSYHLTCARDWLGLSPSSKSFKCPQHACFLCKKKIHLWRCSRCHLASHDKCAAYPEYVLRSNDLPSQTVCWRHATDWPPLKELFGRIPLPYMVEEFKIDPMLKDTMENKLEPPPYVHIRRILAHALKIVYAEICTNKPFRKDKKIKIVLTDSCGWGVEAAEAIKKGEFIIEYVGEVISDALCEQRLWDMKHQGIKNFYMCEIRKDFTIDATFKGNASRFLNHSCGPNCNLEKWDVDGETRVGVFAARSIKAGEPLTYDYRFVQFGAEVKCHCGASSCQGYLGTKKKMAKLELLDWGAKRRRTTTATIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y300</accession>
    <name>A0A103Y300_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002992">
        <property type="protein sequence ID" value="KVI01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI01595">
        <property type="protein sequence ID" value="KVI01595"/>
        <property type="gene ID" value="Ccrd_020130"/>
    </dbReference>
    <dbReference type="OMA" id="MIEAITM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15029" checksum="E8583A14B556FE25" modified="2016-04-13" version="1">MAVLILINLIFSTITMLSILLSHLIFNTTAYLLVIAIQGLXVPGEALQSAMEQIADLIRTCIGYVLEVVMEVISGIVGLVFDLVKEGVFGSVSATGAAAVGVVEKMKSGFDGLTEEIPAVVEGVVEMVTTVVSNLWRVVHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5P0</accession>
    <name>A0A103Y5P0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="12">HMG-CoA reductase</shortName>
            <ecNumber evidence="12">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_018741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01002605">
        <property type="protein sequence ID" value="KVI02967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5P0"/>
    <dbReference type="STRING" id="59895.A0A103Y5P0"/>
    <dbReference type="Gramene" id="KVI02967">
        <property type="protein sequence ID" value="KVI02967"/>
        <property type="gene ID" value="Ccrd_018741"/>
    </dbReference>
    <dbReference type="OMA" id="IMGQCCE"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016135">
        <property type="term" value="P:saponin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000002">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI02967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="461" mass="48715" checksum="C94FF7B0DDC56B91" modified="2016-04-13" version="1">MIDEDKPIKPCGQALIPHIMTTKPTADVAKEKKKPSPTIEHTSEEDEEIVKMVVKGSIPSYALESKLGDCKRAAAVRREALQRITGKSLSGLPLDGFDYDSILGQCCEMPVGYVQIPVGIAGPLLLNGTQFSVPMATTEGCLVASTNRGCKAIFASGGATCILLKDGMTRAPVVRFGSAKRAAELKQFLEDPMNFDTLAVVFNKSSRFGRLQSIRCAIAGKNLYIRFCCSTGDAMGMNMVSKGVQNVLDFLQTDYPDMDVMGISGNYCSDKKPAAVNWIEGRGKSVVCEAVINEEVVEKVLKTTVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLATGQDPAQNIESSHCITMMEAVNDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASTDEPGSNSRVLATIVAGSVLAGELSLMAALAAGQLVKSHMKYNRSTRDMTKLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5Z8</accession>
    <name>A0A103Y5Z8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8018 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002455">
        <property type="protein sequence ID" value="KVI03157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI03157">
        <property type="protein sequence ID" value="KVI03157"/>
        <property type="gene ID" value="Ccrd_018548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058331">
        <property type="entry name" value="DUF8018"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48161:SF1">
        <property type="entry name" value="(RAPE) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48161">
        <property type="entry name" value="BNACNNG12870D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26057">
        <property type="entry name" value="DUF8018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8018" evidence="2">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="358" mass="39780" checksum="43BE02D22C00D25C" modified="2016-04-13" version="1" fragment="single">MGLTLYLGIERGNIACHKSEARFGTLLRERRLASRAFRDEAFWRSQVNFGPPNPATDEKSLWHGVKGSVYVVTLPAFQRCLEDGPDAAKRRPRSGFPTGRGGGRRRPSQGTSRPTGNTGETWEGNPIGSQRIHSTCSLPDFIFIIFESRGRDLFLQRKKNEADLTRHNLTIYPIPMICAXNALLDLYSRKLYRKQRARPVHSSESTIDSLDHPKNDTAGLRGDWVRRGARALDNPRSATGEDSLENLFRILEDLNDTGPLSYSFWELRDKTDAQKTKGPSKSFDGLAGQLTFIGSSDDPIQCNGKIVVLDIDSKSAPHHQLLSADLVVRSKGEGVETSLITPHWARGAPNPPTHTSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y843</accession>
    <name>A0A103Y843_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitinase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_017429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002286">
        <property type="protein sequence ID" value="KVI04266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y843"/>
    <dbReference type="Gramene" id="KVI04266">
        <property type="protein sequence ID" value="KVI04266"/>
        <property type="gene ID" value="Ccrd_017429"/>
    </dbReference>
    <dbReference type="OMA" id="WVHVRSY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02879">
        <property type="entry name" value="GH18_plant_chitinase_class_V"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitotriosidase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF559">
        <property type="entry name" value="CYSTEINE-RICH RLK (RECEPTOR-LIKE KINASE) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119481" evidence="7">
        <location>
            <begin position="24"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="26"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="405"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="736" mass="84491" checksum="F3A67309815FE264" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8A1</accession>
    <name>A0A103Y8A1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002216">
        <property type="protein sequence ID" value="KVI04347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8A1"/>
    <dbReference type="STRING" id="59895.A0A103Y8A1"/>
    <dbReference type="Gramene" id="KVI04347">
        <property type="protein sequence ID" value="KVI04347"/>
        <property type="gene ID" value="Ccrd_017342"/>
    </dbReference>
    <dbReference type="OMA" id="GASEFSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008">
        <property type="entry name" value="COP1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008:SF5">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110401" checksum="803AA384C11CB171" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8K6</accession>
    <name>A0A103Y8K6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pectinesterase</fullName>
            <ecNumber evidence="3 8">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_017169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3 8"/>
    <dbReference type="EMBL" id="LEKV01002020">
        <property type="protein sequence ID" value="KVI04514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8K6"/>
    <dbReference type="STRING" id="59895.A0A103Y8K6"/>
    <dbReference type="Gramene" id="KVI04514">
        <property type="protein sequence ID" value="KVI04514"/>
        <property type="gene ID" value="Ccrd_017169"/>
    </dbReference>
    <dbReference type="OMA" id="SGWHEKT"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF87">
        <property type="entry name" value="PECTINESTERASE 63-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989439" description="Pectinesterase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="371" mass="41933" checksum="3B4CE9F5460DE30A" modified="2016-04-13" version="1">MVKYLLLIVLNTIVIILPPTISDDRVPIPQDRTQVQRWFKHNVKPLATRKGTLDPALEAAEANPRVIRVMKEGGGDFRTINEAVRTIPIKNEQRVIVFIGPGVYSEKIKMERGKKFVTFIGDHAHMPTLTFNGNAAKYTTNSSPRPDGKMKGAQAAAMRIGGDKSAFYNVRFYGFQDTFCDDHGKHFFKDCYIEGTIDFIFGNAKSIYLVSNYDRDEIFKSWLIILCENRFCGNTEIHCIPGHLEAWITAHARKNAEMDTGYVFVHCPVTGTGQGAFLGRAWKPFSRVVFVYSDLGPVVSPKGWNSNNHAQRNLFFGEFGNIGPGSNVALREPFVKQLKRKDIEPFISLAYIEGSKWLLPPPKLKFRSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8S0</accession>
    <name>A0A103Y8S0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C48, SUMO/Sentrin/Ubl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001976">
        <property type="protein sequence ID" value="KVI04585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8S0"/>
    <dbReference type="Gramene" id="KVI04585">
        <property type="protein sequence ID" value="KVI04585"/>
        <property type="gene ID" value="Ccrd_017096"/>
    </dbReference>
    <dbReference type="OMA" id="FPKISHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="690"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="912" mass="103954" checksum="F1D9566A1AA74208" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAB6</accession>
    <name>A0A103YAB6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_016216</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAB6"/>
    <dbReference type="STRING" id="59895.A0A103YAB6"/>
    <dbReference type="Gramene" id="KVI05426">
        <property type="protein sequence ID" value="KVI05426"/>
        <property type="gene ID" value="Ccrd_016216"/>
    </dbReference>
    <dbReference type="OMA" id="PDNANTY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000001">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119531" description="glucan endo-1,3-beta-D-glucosidase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="19">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="52450" checksum="7BA256F374AD2D29" modified="2016-04-13" version="1" fragment="single">MVVNVFIFLLLLPLAVSADQDAFVGVNIGTALSDMPNPTQVAVLLKSQQIRHVRLYDADPAMLFALAGSGIQVTVTVPNQQILAVGQSNATAANWVSRNILPYVSTTNITAISVGSEVLTTIPNAATVLVSAMKYIHSALMSAGLDSKIKVSTAHSSSIILDSFPPSQAFFNRTVEPVMVQLLEFLRSTGSYLMLNVYPYYDYMQSNGVIPLDYALFRPLPPDKEAIDLNTLLHYTNVFDAVVDAAYFAMLYLNYTNIPVVVTESGWPSKGDSSQPDATLDNANTYNSNLIRHVLNNTGTPKHPGVAISTYIYELYNEDLKPGLVSEKNWGLFNADGRPIYVLHLMDSGSVLTNDTAGQTYCVAKNDADKKMLQAALDWACGPGKVNCSMMLQGEPCYLPDTVAAHATYAFDAYYHQMAMADGTCDFNGVATVTTTDPSRDGCTFPGSGGSGSNGTFNNGTASSLAPSSNSTTSGSPLLFGSVSFLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAP1</accession>
    <name>A0A103YAP1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CheY-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAP1"/>
    <dbReference type="STRING" id="59895.A0A103YAP1"/>
    <dbReference type="Gramene" id="KVI05615">
        <property type="protein sequence ID" value="KVI05615"/>
        <property type="gene ID" value="Ccrd_016063"/>
    </dbReference>
    <dbReference type="OMA" id="MNSEEAH"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17581">
        <property type="entry name" value="REC_typeA_ARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF50">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="285" mass="30831" checksum="E1BEDFFDCFA6C9EF" modified="2016-04-13" version="1">MARNGLFSRRWMSPETDQFADVHVLAVDDSLVDRKVIERLLKITSCKVTAVESGWRALQYLGLDQEKTSPDFVNELKVDLIITDYCMPGMTGYELLKKIKGSATFREVPVVIMSSENVVARIDRCLEEGAEDFIVKPVKLSDVKRLKDYMFGENRGTSPPNNINNKEEKTSFNKRKLQEMSDTSPSPSPSPSPSPSPSSSPSPPTVSPSTSPSPPTISPSTSPSPPTISPSTSPSLPTTSPTTSSSPPQSPLSSSSSTPPSSPPFSPSQLDSPTMRLKVTNSDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB44</accession>
    <name>A0A103YB44_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_015852</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 25">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB44"/>
    <dbReference type="STRING" id="59895.A0A103YB44"/>
    <dbReference type="Gramene" id="KVI05843">
        <property type="protein sequence ID" value="KVI05843"/>
        <property type="gene ID" value="Ccrd_015852"/>
    </dbReference>
    <dbReference type="OMA" id="IQHCKRA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009567">
        <property type="term" value="P:double fertilization forming a zygote and endosperm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF520">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE 9, PLASMA MEMBRANE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-transporting P-type ATPase N-terminal autoinhibitory" evidence="22">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="798"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVI05843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111614" checksum="1C9CAD533E43A550" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB69</accession>
    <name>A0A103YB69_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lipoxygenase</fullName>
            <ecNumber evidence="13">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_015799</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; oxylipin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01001860">
        <property type="protein sequence ID" value="KVI05871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB69"/>
    <dbReference type="STRING" id="59895.A0A103YB69"/>
    <dbReference type="Gramene" id="KVI05871">
        <property type="protein sequence ID" value="KVI05871"/>
        <property type="gene ID" value="Ccrd_015799"/>
    </dbReference>
    <dbReference type="OMA" id="LVGWFDK"/>
    <dbReference type="UniPathway" id="UPA00382"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.372.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020833">
        <property type="entry name" value="LipOase_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00711">
        <property type="entry name" value="LIPOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="14">
        <location>
            <begin position="203"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI05871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="777" mass="87860" checksum="25A2A50B77F09220" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBV1</accession>
    <name>A0A103YBV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be a cell surface adhesion protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBV1"/>
    <dbReference type="STRING" id="59895.A0A103YBV1"/>
    <dbReference type="Gramene" id="KVI06229">
        <property type="protein sequence ID" value="KVI06229"/>
        <property type="gene ID" value="Ccrd_015414"/>
    </dbReference>
    <dbReference type="OMA" id="HHIVPTR"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000011">
        <property type="entry name" value="Fasciclin-like arabinogalactan protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044654">
        <property type="entry name" value="FLA15/16/17/18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32499:SF14">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32499">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119564" evidence="10">
        <location>
            <begin position="27"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="11">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="11">
        <location>
            <begin position="260"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI06229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="450" mass="49498" checksum="F148B44C2451E186" modified="2016-04-13" version="1">MASATIYLTFFFLLPLFNQLTTAVDAALPAKPVTQINSNSVLVALLDSRYTELAELVEKALLLQTLEQAVALHNITIFAPRNEALERDLDPEFKRFLLEPRNLRSLQTLLLHHIVPTRLGVSRWPNETTRHDTLSDDPLHLSANLEFVKLVGSAEVVSVEDVVRTDGIIHGIGRLLIPKSVQQDFNTRRSLRAISAIKPEGAPEVDPRTNRLKKPAPPVPVGSAPVLPIYSAMAPGPSLAPAPAPGPGGPHHHFDGESQVKDFIQTLLHYGGYNEMADILVNLTNLATEMGKLVSEGYVLTVLAPNDEAMAKLTTDQLAEPGAPEKIMYYHILPEYQTEESMYNAVRRFGKIQYDTLHVPHKVVGEEADGSVKFGDGEETAYLFDPDIYIDGRISVQGIDGVLFPSPTETNTKKSTESVTTVDPVKVVPKSRRGKLMEVACRMIGFSTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBY4</accession>
    <name>A0A103YBY4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-affinity nitrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001842">
        <property type="protein sequence ID" value="KVI06277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBY4"/>
    <dbReference type="STRING" id="59895.A0A103YBY4"/>
    <dbReference type="Gramene" id="KVI06277">
        <property type="protein sequence ID" value="KVI06277"/>
        <property type="gene ID" value="Ccrd_015383"/>
    </dbReference>
    <dbReference type="OMA" id="WRKANED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010167">
        <property type="term" value="P:response to nitrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016605">
        <property type="entry name" value="Transptr_NO3_Nar2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806:SF11">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16974">
        <property type="entry name" value="NAR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119576" description="High-affinity nitrate transporter" evidence="1">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44788" checksum="85530699EC7AAC2B" modified="2016-04-13" version="1">MEVHPPPLLLLLSCFAIASYAQHEHLLSSLNRSLIVSTTPTPGQVLKIGVDQVTVTWSYNQTLPTAADSNYTRVQVKLCYAPVSQSGRDDRKTDDNLLNDKTCPFDIMDGPYQRSNSSFIWTIPRDIPTATYFIRVYVTDPDDHEVAYGQSTDPLKTTNLFQIEGVTNDQVLAAWPTFKMSLGYSYAWLVAIKRKGIDFLTSKVNPSMEVHLAALLLLFSCFATASYAHNVHLSALNQSLTVSTSTAPDKVLKTGVDQVTITWSYNQTLPTVADSNYTTVEVKLCYAPVSQSGRDDRKTDDNLDNDKTCPFDIMDGPYKRSNNSFVWTIPRDIPTATYFVRVYVINAKNHEIAYGESTNAVKASSLFQIEGVTDDQVQASAAWPTLGNCFGHGYVWLGVLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCJ2</accession>
    <name>A0A103YCJ2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001789">
        <property type="protein sequence ID" value="KVI06599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCJ2"/>
    <dbReference type="STRING" id="59895.A0A103YCJ2"/>
    <dbReference type="Gramene" id="KVI06599">
        <property type="protein sequence ID" value="KVI06599"/>
        <property type="gene ID" value="Ccrd_015053"/>
    </dbReference>
    <dbReference type="OMA" id="ESSASYM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF32">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="221" mass="25638" checksum="A10FA2703D01913D" modified="2016-04-13" version="1">MQEKQLHMIVVQELPDEVSVEEFKWVEEEGKSCCNQDPSSMIGIMFVTLEKISQSDLKHSDIFLLENYAAFQNSLYDMANVVPPLAKFYHQASEFYEQSCSRHISVVIYYHFERLFQFARRIEDLMLTNAPEEIPFQVGMSKADLRKVIKSSLSGVDKHITLMHKKLVKNMTSEELMPTLWDKCKKEFLDKYDSFAQLAAKVYPSESIPSVTEMRDILASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCM3</accession>
    <name>A0A103YCM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001780">
        <property type="protein sequence ID" value="KVI06627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCM3"/>
    <dbReference type="STRING" id="59895.A0A103YCM3"/>
    <dbReference type="Gramene" id="KVI06627">
        <property type="protein sequence ID" value="KVI06627"/>
        <property type="gene ID" value="Ccrd_015019"/>
    </dbReference>
    <dbReference type="OMA" id="ACEVEWL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11071">
        <property type="entry name" value="CYP74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF330">
        <property type="entry name" value="CYTOCHROME P450 SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="478" mass="53103" checksum="1251BF09D23456EC" modified="2016-04-13" version="1">MSSSLTSPIVSSSLNNAARLTTAVRRTAVAGTSSTVSDVNPTTDLPLREIPGSYGIPFFSPIKDRLEYFYAAGGREAYFKSRADKYQSTVFRANMPPGPFIASNPKVIVLLDAKSFPILFDLRHTQLKNLLFYMLQSSSTRVIPKFEETYTELFEALEVDLAKNGKAAFNDVAEQAAFRFLGRAYFDANPEETKLGKEAPKLITLWVLFNLGPQVSIGLPWFLEEPLLHTFQLPAFLIKSSYQKLYDYFISVATPIFEYGATLGIPTDEAAHNILFAVCFNTFGGIKIQFPNTLKWLAPAGKDLHLKLAEEIRGVIKTVGGGTLTLAAIEQMPLLKSVVYEALRIDPPVPLQYAKAKQDLTVESHEARFNVKKGEMLFGFQPFATKDPKIFDRPEEFIPDRFVGDGEALLKYVAWSNGPETEDPTVANKQCAGKNFVVLITRLFLIEFFRRYDSFEAEAVASGLGATITLTSLTKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEJ9</accession>
    <name>A0A103YEJ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001498">
        <property type="protein sequence ID" value="KVI07662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEJ9"/>
    <dbReference type="Gramene" id="KVI07662">
        <property type="protein sequence ID" value="KVI07662"/>
        <property type="gene ID" value="Ccrd_013964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33893" checksum="4FDC8B4DAC72C933" modified="2016-04-13" version="1">MSQKFTTSPKLLRMVKPSALTSGCQKLLYKSGNTYLHQRVYELAKNELASPQGQHLRSVQSERSMVITAKISFKIAAAISRIWNWKLATNGSTIEVFESKSNRTVAALATAGISGSKNKTNCYSFELFVTPVGRFRVSSIDKHSMPSRLASVRLQWLTSIFLKKRKPDKEGNTALGEWCILLGKNVLPQILTSDFATSKARPSTNSVPWTSERRPVDFAQLVDLTNYDIKEQWNPEIMQCNILKQVDTSNMQKEISEKDYNKRERERERKYHSVITHGLDLPDPIRSYDLGTSAYQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF39</accession>
    <name>A0A103YF39_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-JID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001463">
        <property type="protein sequence ID" value="KVI07928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF39"/>
    <dbReference type="Gramene" id="KVI07928">
        <property type="protein sequence ID" value="KVI07928"/>
        <property type="gene ID" value="Ccrd_013714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045344">
        <property type="entry name" value="C-JID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20160">
        <property type="entry name" value="C-JID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C-JID" evidence="3">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="501" mass="55793" checksum="5188059A9E756F0E" modified="2016-04-13" version="1">MQIDGDDYHGELDYKGKVSANTYVYEEKSDQDSEMSLRTRALQKRDRCAAVGHRLSIGVPGSKIPSWFEEQQHGCTVALRLPPMLHTQVIGFAICGVFHGNWTYDYPRIIFRIVNDKKVVPKLEVDHIESAATENCNIWVTYIPFGFFQQMYHDLQPQDWSHIQGSLVMTLAKTNGYDVKVPANTYVYEEKTDEKDSNLRRLGSRTSERRELYNRAVISTQCSGTRGMASISLILQRREMTIQSPKPMIQSPIKHVFEKVDISINKLGPTHYCVPHPSSLLCTNSTSIPQSITFQTPIDLLNVAIDVLRFLIVPNVAIDLLNMICQLAANDMGQDNDSGPTKHVGLLAHEGLIVGLFTIDEPEGKAHASSDLFFQSTAFVLIVFPLLPFINSITSFLISSLFTSLSISIATPHLLQLNQLFGCWSAKNGQQSIGTPLEMLSIAEFHPLCVKNPPIDGCFRTCSWGHQLAKNPLSFVSTKKSGGSTALSPITRSGRIIHKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFA6</accession>
    <name>A0A103YFA6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001382">
        <property type="protein sequence ID" value="KVI08036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFA6"/>
    <dbReference type="Gramene" id="KVI08036">
        <property type="protein sequence ID" value="KVI08036"/>
        <property type="gene ID" value="Ccrd_013599"/>
    </dbReference>
    <dbReference type="OMA" id="KKTMAFW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040273">
        <property type="entry name" value="PIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37245:SF4">
        <property type="entry name" value="PAMP-INDUCED SECRETED PEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119668" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7780" checksum="AC8FC93432450722" modified="2016-04-13" version="1">MAFKKTFTLLVIVAILIAVMSPVVVQGRVLSEDFAGSNHLATYSTVYEKAKTGMSFWLQRLASGPSPRGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG61</accession>
    <name>A0A103YG61_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001111">
        <property type="protein sequence ID" value="KVI08509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG61"/>
    <dbReference type="STRING" id="59895.A0A103YG61"/>
    <dbReference type="Gramene" id="KVI08509">
        <property type="protein sequence ID" value="KVI08509"/>
        <property type="gene ID" value="Ccrd_013129"/>
    </dbReference>
    <dbReference type="OMA" id="WGLRTTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000004">
        <property type="entry name" value="Outer envelope protein 64, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006169">
        <property type="entry name" value="PRK08310.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="439" mass="47230" checksum="587AA18318FB12E7" modified="2016-04-13" version="1">MTIARDLDYGAFMEKFILPPSPASSPEQLPLNRLTFAVKDINCFVCVNLFVINIGTQSRFDMDGYVTGFGNPDWLRTHSAATSTAPAVLAMLKAGATCLGRTVMDEMAYSINGENVHYGTPANPCAPDRVPGGSSSGSAVAVGATLVDFSLGTDTGGSVRVPASYCGIFGFRPSHGIVSTDGVIPMAQSFDTVGWFSRDPGTLNHVGKILLQLPDEKHVRPSRVLIAEDCFKLLSIPSTRVTNVIARSVENLFGVPSLKHFMEDDFENQEFSISSLVALSTAMRLLQRFEFKKNHGEWVSTVKPDLGPGISERVLDALKTSGEHIDACESVKTQLREALTALLGEHGILVIPTVPGPPPKLQTDPTLLETFRARAFSLLSVAGVSGLCQVTIPLGKYNDLPVAVSLLANHGSDGFLLSLVETLYDTLKQEVEVAEKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGG5</accession>
    <name>A0A103YGG5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001100">
        <property type="protein sequence ID" value="KVI08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGG5"/>
    <dbReference type="Gramene" id="KVI08637">
        <property type="protein sequence ID" value="KVI08637"/>
        <property type="gene ID" value="Ccrd_012983"/>
    </dbReference>
    <dbReference type="OMA" id="LMSKYPY"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF43">
        <property type="entry name" value="EXOSTOSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="7">
        <location>
            <begin position="101"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="48797" checksum="DF062CFC948B6B9A" modified="2016-04-13" version="1">MSAAKPLPSQSPPSFTAISTKQGLILILSTLTLLTFSYISFTSLGSTLQYNYSYPPPTTTLTAASTLKEDVDVEDGASTKSDGFSDVYHSPEVFKLNYAEMEKRFKVYIYPDGDPKTFYQTPRKLTGKYASEGYFFQNIRESRFKTDDPDQAHLFFIPISCHKMRGKGTSYENMTIIVQNYVESLISKYPYWNRTLGADHFFVTCHDVGVRATEGLPLLVKNSIRAVCSPSYDVGFIPHKDIALPQVLQPFALPRGGDDIENRTTLGFWAGHRNSKIRVILARTWENDTELDISNNRINRASGHLVYQKRFYRTKFCICPGGSQVNSARIADSIHYGCIPVILSNYYDLPFNDILDWGKFSVILEEKDVYQLKQILKDISDEQFVTLHNNLVKIQKHFQWNTPPIPYDAFHMVMYDLWLRHNVIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGY1</accession>
    <name>A0A103YGY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001080">
        <property type="protein sequence ID" value="KVI08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGY1"/>
    <dbReference type="STRING" id="59895.A0A103YGY1"/>
    <dbReference type="Gramene" id="KVI08894">
        <property type="protein sequence ID" value="KVI08894"/>
        <property type="gene ID" value="Ccrd_012733"/>
    </dbReference>
    <dbReference type="OMA" id="IMYHIYK"/>
    <dbReference type="OrthoDB" id="509361at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032544">
        <property type="term" value="P:plastid translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040320">
        <property type="entry name" value="At4g37920-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31755">
        <property type="entry name" value="FOLATE RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31755:SF2">
        <property type="entry name" value="OS08G0320800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="46536" checksum="7A2F5769B6F023C0" modified="2016-04-13" version="1">MNSNLLGFQTTNPPSLFPFTTQSLLFTSPKSSFLSFKSLKPPTTNFKILCGNPGMAAQLVEEQEVEIAEGYTMTKFCDKLIDVFLTENSKPKHWMRYLIFREDWNKYRDGFYSRCKLRADGENDLTLKQSLITLATEVKRVDDEMERHSELLKQIEDSPMDINAIVTKRRKDFTGEFFRYLAVVQESHDSLEDRDAVARLGARCLSAVSAYDNTLETMETLDTAQAKFDDILNSPSIEAACAKIKSLAKTKELDSSLILLINSAWASAKESSTMKNEVKAIMYQLYKATKSSLKSIAPKEIKLLKYLLNFTDPEDRFSALATAFSPGKDSEAKDPNAIYTTPEELHKWITFMLDAYQLHKEETDIMEAKEMNLPMVIQRLSILKETIEEEYMEKETPEANKDTNAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIZ1</accession>
    <name>A0A103YIZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001036">
        <property type="protein sequence ID" value="KVI09957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIZ1"/>
    <dbReference type="STRING" id="59895.A0A103YIZ1"/>
    <dbReference type="Gramene" id="KVI09957">
        <property type="protein sequence ID" value="KVI09957"/>
        <property type="gene ID" value="Ccrd_011658"/>
    </dbReference>
    <dbReference type="OMA" id="CALIFLE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053772">
        <property type="entry name" value="At1g61320/At1g61330-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055357">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145:SF68">
        <property type="entry name" value="FBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145">
        <property type="entry name" value="OS02G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23622">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At1g61320/AtMIF1 LRR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="19692" checksum="83956EFA7742D577" modified="2016-04-13" version="1">MEMINDMFCQISCCVPYLQILELDLYRLQVSIELLPFPKLPKLKGMTIRVVEQGEDGVLALTSLVEACPNLQRFSIMKTSLFSAGKMDREVRQMAKKPHQHLEVVEIDEYHGGTSDLELVMYFIQNCVALKKLVIEATMEDEDEDEDEDGGRYRAQQQLEPRIPDGVELVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ90</accession>
    <name>A0A103YJ90_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Remorin, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the remorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ90"/>
    <dbReference type="STRING" id="59895.A0A103YJ90"/>
    <dbReference type="Gramene" id="KVI10131">
        <property type="protein sequence ID" value="KVI10131"/>
        <property type="gene ID" value="Ccrd_011464"/>
    </dbReference>
    <dbReference type="OMA" id="SAWENSM"/>
    <dbReference type="OrthoDB" id="684343at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005516">
        <property type="entry name" value="Remorin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005518">
        <property type="entry name" value="Remorin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31775">
        <property type="entry name" value="OS02G0117200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31775:SF34">
        <property type="entry name" value="REMORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03763">
        <property type="entry name" value="Remorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03766">
        <property type="entry name" value="Remorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Remorin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Remorin C-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="193" mass="21721" checksum="0A6E8A5AC892A90B" modified="2016-04-13" version="1">MAVEEAKKVEVEPECQPEPPVAAAEKEEEKALVPVEPLVSEEKPTDDTKALIVVEKPEEVCDEKPKEGSINRDDVLAKVATEKKDALIKAWEESEKSKAENKAQQKLSSIEAWEISKKAELEAELKKIEEDLEKKKAKYIEKMKNKMAILHKRAQEKRAITEAKCGEELLKAEELAAKCRATGDTPKKLLGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJF2</accession>
    <name>A0A103YJF2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJF2"/>
    <dbReference type="STRING" id="59895.A0A103YJF2"/>
    <dbReference type="Gramene" id="KVI10249">
        <property type="protein sequence ID" value="KVI10249"/>
        <property type="gene ID" value="Ccrd_011351"/>
    </dbReference>
    <dbReference type="OMA" id="PCTRCQM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="615"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="753" mass="84254" checksum="47DF1DFAC0AE8388" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJG4</accession>
    <name>A0A103YJG4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_011357</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJG4"/>
    <dbReference type="Gramene" id="KVI10251">
        <property type="protein sequence ID" value="KVI10251"/>
        <property type="gene ID" value="Ccrd_011357"/>
    </dbReference>
    <dbReference type="OMA" id="ISATNQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000002">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000140">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001380">
        <property type="entry name" value="Os05g0256100 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000298">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF62">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119782" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="657"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVI10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="953" mass="104746" checksum="2338733311C41E67" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKK2</accession>
    <name>A0A103YKK2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01000988">
        <property type="protein sequence ID" value="KVI10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKK2"/>
    <dbReference type="STRING" id="59895.A0A103YKK2"/>
    <dbReference type="Gramene" id="KVI10866">
        <property type="protein sequence ID" value="KVI10866"/>
        <property type="gene ID" value="Ccrd_010740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000018">
        <property type="entry name" value="Glutathione S-transferase U20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF793">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="250"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="336"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="464" mass="54198" checksum="3F70FEF8A2FE47AE" modified="2016-04-13" version="1">MHTQTSYLHIRRCKIYTNPVLTFHLVLVMASSNDLVLLNFWASPFGERVKIALAEKGVHYDYKEENLADKSPLLLQMNPVHKKVPVLIHHDKPIFESNIIVQYIDETWQNEDPPLLPSDPYLKAQARFWADYVDNNVRFSAIWRTKGEEQERAKKEFIDLLKVLEEQLGEKPYLIGESFGYADIALIPLSCRFYALEIIGKMNIEKECPKLMEWVKRCMERESVSKSLPDPHKIYEVLIFHLILQMASSNDVVLLNFWASPFGERVEIALAEKGVHYDYKEEDWADKSSLLLQMNPVHKKLPVLIHHGKPICESNIIVQYIDETWQTEDPPLLPSDPYLKAQARFWADFVDNKVNFSAIWRTKGEEQERAKKEFIDLLKVLEEQLGEKPYLIGESFGYADIALIPFSCWFYAVEIIGKMNIEKECPKFIEWVKRCMERESVSKSLPDPHKIYEYVLELMKKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL22</accession>
    <name>A0A103YL22_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000942">
        <property type="protein sequence ID" value="KVI11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL22"/>
    <dbReference type="Gramene" id="KVI11039">
        <property type="protein sequence ID" value="KVI11039"/>
        <property type="gene ID" value="Ccrd_010555"/>
    </dbReference>
    <dbReference type="OMA" id="GANMNCS"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07245">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46142:SF13">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE_GLYOXALASE I FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="22974" checksum="AC1AC58F47B28006" modified="2016-04-13" version="1">MANQVVNGGHNEQHVSSSLPFLSLNHVSFICRSVPTSVKFYNDVLGFVLIRRPSSFDFEGAWLFNHGIGIHLLQVETTPTKRGVINPKDNHISFQCTDMDRIIKKLEELDIKYVTAVVKEGGVEVNQLFFHDPDGYMIEICNCHVLPMLPITSCPLKKLPPIPQTNQVESSSYDKMVSKNYYCGEDEAIMMENFLIDMMGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM21</accession>
    <name>A0A103YM21_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_010012</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01000076">
        <property type="protein sequence ID" value="KVI11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM21"/>
    <dbReference type="STRING" id="59895.A0A103YM21"/>
    <dbReference type="Gramene" id="KVI11574">
        <property type="protein sequence ID" value="KVI11574"/>
        <property type="gene ID" value="Ccrd_010012"/>
    </dbReference>
    <dbReference type="OMA" id="VAQYEDP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000007">
        <property type="entry name" value="Phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000048">
        <property type="entry name" value="Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF127">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C AND CYCLIC NUCLEOTIDE-BINDING_KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="89"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="473"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="599"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="697"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="905" mass="99321" checksum="DF5F6A20F0AB460B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118EH46</accession>
    <name>A0A118EH46_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01010211">
        <property type="protein sequence ID" value="KVE71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118EH46"/>
    <dbReference type="Gramene" id="KVE71617">
        <property type="protein sequence ID" value="KVE71617"/>
        <property type="gene ID" value="Ccrd_023912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVE71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="18137" checksum="17128AF414E1E0E7" modified="2016-04-13" version="1" fragment="single">MSLARLYARSSHFSSLCKTLNHTPVRSRCLLEVGQRIYNSVGASSSRHGQCCSEFRNFTSGSELSXKSFNKISHLGVGYLKRPYVLGSHHQYTTNVVREQKSRKILYYLTGLVFAMVGCTYASVLLYRRFCQATGYGGTVQRRETVEEKIARHAQDGTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118IA76</accession>
    <name>A0A118IA76_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAP30-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007301">
        <property type="protein sequence ID" value="KVG98064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118IA76"/>
    <dbReference type="STRING" id="59895.A0A118IA76"/>
    <dbReference type="Gramene" id="KVG98064">
        <property type="protein sequence ID" value="KVG98064"/>
        <property type="gene ID" value="Ccrd_026039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG98064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="18110" checksum="ED131EE478B9156D" modified="2016-04-13" version="1" fragment="single">MCAKVGVDPLASNKGFWAGLLGIGDFYYELGMCLFLLLLLGGVQIVDVCLATRPHNRGVINLDELCKLLSSEDDCLRAIGKLKVLGSGFEVITVGKRKLACSVPNELKKDHNEILELSQGPSTHSLLKTSGNISSSKIKIVSFRTSIMNMRTLGLMLELKVNEDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRR5</accession>
    <name>A0A118JRR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005997">
        <property type="protein sequence ID" value="KVH87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRR5"/>
    <dbReference type="STRING" id="59895.A0A118JRR5"/>
    <dbReference type="Gramene" id="KVH87627">
        <property type="protein sequence ID" value="KVH87627"/>
        <property type="gene ID" value="Ccrd_025088"/>
    </dbReference>
    <dbReference type="OMA" id="CLRNEYI"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="83" mass="9918" checksum="5A1F98870219A166" modified="2016-04-13" version="1">MHPPLTLHRHPMCAEIIEQFQKCHLDHPYAKFFGECTDLKIKLDKCFRQEKAVKRKANFEESKKLKERLQAYRKEAAESENVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT48</accession>
    <name>A0A118JT48_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_008592</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01005211">
        <property type="protein sequence ID" value="KVH89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT48"/>
    <dbReference type="STRING" id="59895.A0A118JT48"/>
    <dbReference type="Gramene" id="KVH89422">
        <property type="protein sequence ID" value="KVH89422"/>
        <property type="gene ID" value="Ccrd_008592"/>
    </dbReference>
    <dbReference type="OMA" id="AAFKHSW"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000025">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="633" mass="70789" checksum="EE6621B0670CD01E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU65</accession>
    <name>A0A118JU65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclin A/B/D/E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the CDC2 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004930">
        <property type="protein sequence ID" value="KVH91526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU65"/>
    <dbReference type="STRING" id="59895.A0A118JU65"/>
    <dbReference type="Gramene" id="KVH91526">
        <property type="protein sequence ID" value="KVH91526"/>
        <property type="gene ID" value="Ccrd_006452"/>
    </dbReference>
    <dbReference type="OMA" id="CISERNY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20567">
        <property type="entry name" value="CYCLIN_AtCycB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000032">
        <property type="entry name" value="G2/mitotic-specific cyclin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="197"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="294"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="421" mass="47106" checksum="85EEC488C425D178" modified="2016-04-13" version="1">MTSYEPVVPIQQQNIVADVKQKHERRNRKALGDIGNLAAAPVVEIGKPQTQISRPITSLMILIRTFRAQLLANGQAAADKNIKKPLAEENNGNLVSKQKKEVVGNHEETPKRRTRKPSKTLTSVLTARSKAACGITTKPKDPVVNIDESDINNELAEVEYVEDIYTFYKLSETEGGLRDYMNLQPDLNAKMRAILVDWLIEVHRKFELMPESIYLTINIVDRYLSQKPVPRRELQLVGISAMLIACKYEEIWPPEVNDLMVISDNAYTRDQILAMEKAILGELGWYLTVPTPYVFLVRYTKASIPSDDEMGNMVFFLTELGLIHYSVIITNNPSKLAASAVYAARCTLNKTPAWTETLKHHTGYSEDQLRECAKVLVSFHACASETKLKAVYRKYVNPEKGAVALFPAARSLVAEVGGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV05</accession>
    <name>A0A118JV05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S5 domain 2-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_004656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004783">
        <property type="protein sequence ID" value="KVH93294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV05"/>
    <dbReference type="STRING" id="59895.A0A118JV05"/>
    <dbReference type="Gramene" id="KVH93294">
        <property type="protein sequence ID" value="KVH93294"/>
        <property type="gene ID" value="Ccrd_004656"/>
    </dbReference>
    <dbReference type="OMA" id="EVIKPHM"/>
    <dbReference type="OrthoDB" id="186964at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH93294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="16409" checksum="E7EDD2CB1E1C5A2D" modified="2016-04-13" version="1">MAAPPPNSVQCFGRKKTAVAVTHCKAGRGLIKINGVPIELVQPEILRYKAFEPILLLGRHKFAGVDMRIRVKGGGHTSQIYAIRQSIAKALVAYYQKFVDEEQKKEIKDILVRYDRTLLVADPRRCEPKKFGGRGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWL3</accession>
    <name>A0A118JWL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004538">
        <property type="protein sequence ID" value="KVH94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWL3"/>
    <dbReference type="STRING" id="59895.A0A118JWL3"/>
    <dbReference type="Gramene" id="KVH94659">
        <property type="protein sequence ID" value="KVH94659"/>
        <property type="gene ID" value="Ccrd_003285"/>
    </dbReference>
    <dbReference type="OrthoDB" id="780709at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052426">
        <property type="entry name" value="Plant_dev_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801:SF84">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801">
        <property type="entry name" value="OS07G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="15569" checksum="B67080111DA6CB0E" modified="2016-04-13" version="1">MEPNQVVVSESSDEAIDTVQERNTTQTTGRSYECTFCKRGFTNAQALGGHMNIHRKHKAKLKESSFSPPPNAAATATTTTAISPFSISTQGKNKPLSLFGGGSSDSTENATKDDPPSPALELDLELRLGHVESPGNKITATRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWR3</accession>
    <name>A0A118JWR3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_003196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004529">
        <property type="protein sequence ID" value="KVH94722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWR3"/>
    <dbReference type="STRING" id="59895.A0A118JWR3"/>
    <dbReference type="Gramene" id="KVH94722">
        <property type="protein sequence ID" value="KVH94722"/>
        <property type="gene ID" value="Ccrd_003196"/>
    </dbReference>
    <dbReference type="OMA" id="MIMEAYP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH94722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28594" checksum="EF4903FB0D777814" modified="2016-04-13" version="1">MVGGERRRCIYRDVLPFAAMVMVEFMIVGGNTLFKSATAQGSINSYVFTFYVFLLGFFFLLPCLFILNRRTTIPPIKFSIVVKIFLLSYGSPTLSSIMSNLSPAFTFMLAFFFRMETIDFRTYTTRAKVTGTIVSIAGALVAMLYSGPTRSTYSFSLNSVIGGVLLASQYFLVAFALVAQAKIMLSYPIDIMVVFVFSVSGLFVAGLAGLVMARDSDAWKLKLDKGPVYVAMFKPLTIVIAIVMGVLFLGDSLQFGRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX47</accession>
    <name>A0A118JX47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004311">
        <property type="protein sequence ID" value="KVH96429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX47"/>
    <dbReference type="STRING" id="59895.A0A118JX47"/>
    <dbReference type="Gramene" id="KVH96429">
        <property type="protein sequence ID" value="KVH96429"/>
        <property type="gene ID" value="Ccrd_001491"/>
    </dbReference>
    <dbReference type="OMA" id="FPRYFIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF350">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="180" mass="19843" checksum="E7439E9C71009D2F" modified="2016-04-13" version="1">MANSAFSDQIPSSSVYGGGGGGGLFDIPQGYSYLDMLGFQQDYGGASSLFDLLQQPSSVVEAPAPPETSEVVNTPTTISSSLSSSSNDHLNDVDQENNNTRSDDDQQKSADKQLKAKKKNPKKQREPRFAFMTKTEVDHLDDGYRWRKYGQKAVKNSPFPRYFITSDFALDVAEISVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYJ3</accession>
    <name>A0A118JYJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19 conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003750">
        <property type="protein sequence ID" value="KVH98724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYJ3"/>
    <dbReference type="STRING" id="59895.A0A118JYJ3"/>
    <dbReference type="Gramene" id="KVH98724">
        <property type="protein sequence ID" value="KVH98724"/>
        <property type="gene ID" value="Ccrd_023049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="8368" checksum="66626C3B603015EC" modified="2016-04-13" version="1">MVSHTIAIHNGKEHLPIYITDHMVGHKLGEFGPTLNFRGQAKSIIDLVEANFMLNKRTTEVYALGQHISMSAHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1Q5</accession>
    <name>A0A118K1Q5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002622">
        <property type="protein sequence ID" value="KVI02881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1Q5"/>
    <dbReference type="STRING" id="59895.A0A118K1Q5"/>
    <dbReference type="Gramene" id="KVI02881">
        <property type="protein sequence ID" value="KVI02881"/>
        <property type="gene ID" value="Ccrd_018834"/>
    </dbReference>
    <dbReference type="OMA" id="YQIPMLV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="32831" checksum="8446CAB2B3257889" modified="2016-04-13" version="1">MEGMMKMGDVNHHRIKTNGIWMHVAEKGDEQGPLVLLLHGFPDTWFSWRHQIGHLASQGYHVLAPDLRGFGDSDSPPSPTAYTIFHIVADLLGLLHHFNHQQVFVVGHDWGATAAWHLSLFRPDKVKGMVAISEAGRAEKSFAKYDYLTVMKKFWMIEKVVSPPGMEFIDCLETPSVLPPWITEEELQVYADKFQESGFTGGLNYYRAMDLNWELQAPWQGSKVTVPSKLIIGDKDIGFGGTKEYVDGDVFKGLVPDIEVVILEGHHFIQQEKPKQVSDQIISFLEKLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1T8</accession>
    <name>A0A118K1T8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_018419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002385">
        <property type="protein sequence ID" value="KVI03286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1T8"/>
    <dbReference type="STRING" id="59895.A0A118K1T8"/>
    <dbReference type="Gramene" id="KVI03286">
        <property type="protein sequence ID" value="KVI03286"/>
        <property type="gene ID" value="Ccrd_018419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI03286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="32865" checksum="5F1110438789D9D5" modified="2016-04-13" version="1">MDGTGVVAVYGNGAITESRKSPYSVKVGLAQMLRGGVIMDVVNEEQARIAEEAGACAVMALERVPADIRAQGGVARMSDPQLIKEIKQAVTIPVMAKARIGHFVEAQILEAIGVDYVDESEVLTVADDANHINKHNFRIPFVCGCRNLGEALRRIREGAAMIRTKGEAGTGNIIEAVRHARSVMGDIRRLANMDDDEVFGAAKNMGAPYDLVMQTKQLGRLPVVQFAAGGVATPADAALMMQLGCDGVFVGSGVFKSGDPPRRARAIVQAVTHYTDPKVLAEVSCGLGEAMVGLNLDKNVERYSTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2J9</accession>
    <name>A0A118K2J9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002050">
        <property type="protein sequence ID" value="KVI04453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2J9"/>
    <dbReference type="Gramene" id="KVI04453">
        <property type="protein sequence ID" value="KVI04453"/>
        <property type="gene ID" value="Ccrd_017230"/>
    </dbReference>
    <dbReference type="OMA" id="HGDVDCG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000525">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000343">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g58590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF532">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="680" mass="76312" checksum="B44FE259A72AAC10" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2N7</accession>
    <name>A0A118K2N7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_016993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLAC1 S-type anion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001939">
        <property type="protein sequence ID" value="KVI04681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2N7"/>
    <dbReference type="STRING" id="59895.A0A118K2N7"/>
    <dbReference type="Gramene" id="KVI04681">
        <property type="protein sequence ID" value="KVI04681"/>
        <property type="gene ID" value="Ccrd_016993"/>
    </dbReference>
    <dbReference type="OMA" id="LYIETCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09323">
        <property type="entry name" value="TDT_SLAC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030183">
        <property type="entry name" value="SLAC/SLAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31269">
        <property type="entry name" value="S-TYPE ANION CHANNEL SLAH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31269:SF41">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="570" mass="64159" checksum="3156B5A881619BF7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K302</accession>
    <name>A0A118K302_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K302"/>
    <dbReference type="STRING" id="59895.A0A118K302"/>
    <dbReference type="Gramene" id="KVI05175">
        <property type="protein sequence ID" value="KVI05175"/>
        <property type="gene ID" value="Ccrd_016511"/>
    </dbReference>
    <dbReference type="OMA" id="NTHSIMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF18">
        <property type="entry name" value="DNA-BINDING PROTEIN MNB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="14290" checksum="7187CCA8B715D684" modified="2016-04-13" version="1">MKGGKSSGGTRKADTKLAVKKTQAKGKAVKDPNKPKRPASAFFVFMEEFRKQFKEENPGNKSVAAEKAPYVAKADKRKKEYEKNMASYNKKLSAGDKEEDDESDKSKSEVNDEEDEEESEDEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K389</accession>
    <name>A0A118K389_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K389"/>
    <dbReference type="Gramene" id="KVI05581">
        <property type="protein sequence ID" value="KVI05581"/>
        <property type="gene ID" value="Ccrd_016090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8303" checksum="4AE80D5334CB445C" modified="2016-04-13" version="1">MESQVTPRVPSNTSLEIFCRQLLARSSTEEFGGTLGRSSILRIDAHLSVFTSEVQVRLQTSFKQVLLSFCNVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3I2</accession>
    <name>A0A118K3I2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine-threonine kinase receptor-associated protein</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_015651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3I2"/>
    <dbReference type="STRING" id="59895.A0A118K3I2"/>
    <dbReference type="Gramene" id="KVI05983">
        <property type="protein sequence ID" value="KVI05983"/>
        <property type="gene ID" value="Ccrd_015651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000133">
        <property type="entry name" value="Serine-threonine kinase receptor-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI05983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="541" mass="59351" checksum="C21B035ADB3D8F09" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3T3</accession>
    <name>A0A118K3T3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DEAD/DEAH-box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001828">
        <property type="protein sequence ID" value="KVI06448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3T3"/>
    <dbReference type="STRING" id="59895.A0A118K3T3"/>
    <dbReference type="Gramene" id="KVI06448">
        <property type="protein sequence ID" value="KVI06448"/>
        <property type="gene ID" value="Ccrd_015206"/>
    </dbReference>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="502"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="742"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI06448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1280" mass="142723" checksum="600BC6B4A46D7996" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4E8</accession>
    <name>A0A118K4E8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4E8"/>
    <dbReference type="STRING" id="59895.A0A118K4E8"/>
    <dbReference type="Gramene" id="KVI07382">
        <property type="protein sequence ID" value="KVI07382"/>
        <property type="gene ID" value="Ccrd_014334"/>
    </dbReference>
    <dbReference type="OMA" id="QPRNGFN"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF11">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN DDB_G0270170-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="57494" checksum="E955EECD213F7386" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5B0</accession>
    <name>A0A118K5B0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001088">
        <property type="protein sequence ID" value="KVI08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5B0"/>
    <dbReference type="STRING" id="59895.A0A118K5B0"/>
    <dbReference type="Gramene" id="KVI08818">
        <property type="protein sequence ID" value="KVI08818"/>
        <property type="gene ID" value="Ccrd_012810"/>
    </dbReference>
    <dbReference type="OMA" id="HIYEPHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000094">
        <property type="entry name" value="GTPase Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF2">
        <property type="entry name" value="GTPASE ERA-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Era-type G" evidence="5">
        <location>
            <begin position="111"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="4">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="4">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="4">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="4">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="4">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="378" mass="42764" checksum="812B82CCBA578558" modified="2016-04-13" version="1">MELSLQRISPALPNTLFLFSPHPSSLSAFPYNLRRQFQFHAVSSSSVSSPPKQLLCSLGGSQFKQEQVEEEEDGYGTSAFLSLSSKPDRNMAMLDDYEMEEFDYLSDPNHRSGYVAVVGKPNVGKSTLSNQMIGQKLSIVTDKPQTTRHRILGICSTPEYQMILYDTPGVIEKKMHKLDSMMMKNVRSATINADCVLVVVDACKPPENINEVLKEGVGELKDNVPVLLVLNKRDLIKPGEIAKKLEWYEKSTDVDEVIPVSAKYGHGVDDDITSEHPERFFIAEIVREKIFMQFRNEVPYACQVNVINYKARPDAKDFIQVEIDGRALKLLATASRLDIEDFLQKKVFLEVEVKVKENWRQDEGLLKYYGYGGKIQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5T3</accession>
    <name>A0A118K5T3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001054">
        <property type="protein sequence ID" value="KVI09573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5T3"/>
    <dbReference type="STRING" id="59895.A0A118K5T3"/>
    <dbReference type="Gramene" id="KVI09573">
        <property type="protein sequence ID" value="KVI09573"/>
        <property type="gene ID" value="Ccrd_012042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373:SF23">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20817" checksum="3FE65821CDABB969" modified="2016-04-13" version="1">MLSSLSISGKCRELIRMSDTIDGYGTTRAYLFIVENQKKHLNWLDGLTMYLHVGVVELVDMLFNTDFRRNVVIIEASPCSLKGPLFLGMTKKADGQDKPQRPALLILRGGLVAKSAELAWHEMRRAWAGDRSQTSHSKFRQPIMSWTTSFEDLLSSGEPFPEPIPLADVVDLLVDIWIEEGFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K647</accession>
    <name>A0A118K647_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinesin, motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K647"/>
    <dbReference type="STRING" id="59895.A0A118K647"/>
    <dbReference type="Gramene" id="KVI10113">
        <property type="protein sequence ID" value="KVI10113"/>
        <property type="gene ID" value="Ccrd_011453"/>
    </dbReference>
    <dbReference type="OMA" id="CTPWKTF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="509" mass="55610" checksum="437AE722B78EE519" modified="2016-04-13" version="1">MTPSSRNQMKSCSNLSGKVRVIARIRGFRDHELASKSVIQVCKSSGSGPSEKVTLSFDDQTSSRKNEYEVDHCYHQNEDTALIFSMEIKPHISKVFDGESSTFIAFGARGTGKTYTIQGSKENVGLGMMVMDEILKMVEGGKHAVAVSIYEVFQDHVYDILDSKNPEVPVKSMLEFQNLYCMGSTSNKPKQKIAPELPRRSHKALMIHILACDKGGNPKCVGKMNFVDLADTIHAVTLASRLKSIKPSMTAKKQTNSSVPLSANKADSVVAARSAAKKGTNSRLPMSGKKTNAVLKERRNIFGDTDAEQANGFKKQANKPSNLVKSDIPNGDSAVVKEEKGSSDGALYSDVIDVASAIVPCDNIVKEDNNLLVNEGQSPPLSVRLKELSMNLQSLCSTPLPTSTPQVANTEIGNIIDAVEPKTPIVTHKMDFSNCPSGTFSKRSSGMKQSLVQDYLEFLNTASKEDLKGIWGIGEKRASYICELREESPQPFKNVKRMMKKVAGELFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K690</accession>
    <name>A0A118K690_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase, cytosolic</fullName>
            <ecNumber evidence="4">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_011369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K690"/>
    <dbReference type="STRING" id="59895.A0A118K690"/>
    <dbReference type="Gramene" id="KVI10262">
        <property type="protein sequence ID" value="KVI10262"/>
        <property type="gene ID" value="Ccrd_011369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="84"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="443"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="767" mass="81575" checksum="B86FCB64248A84EC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6M7</accession>
    <name>A0A118K6M7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000974">
        <property type="protein sequence ID" value="KVI10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6M7"/>
    <dbReference type="STRING" id="59895.A0A118K6M7"/>
    <dbReference type="Gramene" id="KVI10937">
        <property type="protein sequence ID" value="KVI10937"/>
        <property type="gene ID" value="Ccrd_010649"/>
    </dbReference>
    <dbReference type="OMA" id="RFFHLVW"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42841">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="495" mass="53982" checksum="114E681486EBA032" modified="2016-04-13" version="1">MAITAHSFLSSSNLSFVPHHTFHHRRRRHHLPLSPIKISAQLSLTTPPSPTLQPNLNKTGVIVVGAGLAGLAAAVRLHSDNIPFLLVEASDAVGGRVRTDNVDGFLLDRGFQIFITGYPEARKILDYESLDLRKFYSGAKVYYGGGFHTVADPLRHLADAIQSLTNPIGTVVDKSLIALTRIRVLTQSDDQIFSAEETSTSDLLKRIGFSDSIVDRFFRPFFGGIFFDRDLETTSRLFDFIFKCLALGDNTLPAKGISAIPEQLAAKLPSDSIILNTPVASIDKQESESKSESTYTVRLNNGEVLNADYGVIVAVEEPEAVKLLAGKSNGFPAQIKKPIRSTVCLYFSANRSEVPIQDPVLFINGSGNGIVNNMFFATNVAPSYGPPGKVLVSVSLIGLHADASDEDLKSNVVEELSSWFGKEVVGSWTHLRTYRVKFAQPNQCPPTDLRKNPKVERGLYVCGDYRTSATFDGALVSGRKAAEALLRDRSSVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124PVN5</accession>
    <name>A0A124PVN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L5 eukaryotic/L18 archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit (LSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009969">
        <property type="protein sequence ID" value="KVE95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124PVN5"/>
    <dbReference type="STRING" id="59895.A0A124PVN5"/>
    <dbReference type="Gramene" id="KVE95214">
        <property type="protein sequence ID" value="KVE95214"/>
        <property type="gene ID" value="Ccrd_026882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="8">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVE95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12398" checksum="6A7CF4191E2C5825" modified="2016-04-13" version="1" fragment="single">VNGSLRSYSEVIRIAYSTSFFSSLTCPPQVHLWRACCFLHEGECSLTRDVTLMEDEPEKYQSRFSEYIKVGVDPENIEELYKKVHSAIHADPTPKKLDKQPPKEHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124REM7</accession>
    <name>A0A124REM7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAC motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007653">
        <property type="protein sequence ID" value="KVG77631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124REM7"/>
    <dbReference type="STRING" id="59895.A0A124REM7"/>
    <dbReference type="Gramene" id="KVG77631">
        <property type="protein sequence ID" value="KVG77631"/>
        <property type="gene ID" value="Ccrd_026204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175:SF2">
        <property type="entry name" value="ADAGIO PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVG77631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="125" mass="14347" checksum="F88784B956F5CCF8" modified="2016-04-13" version="1">MIALFRLSSLACRCIPHYKDPRAQRRYPLVDPVCVSKIRRCLDEDIDFQGELLNFRKDGTPLVNRLRLAPIHGDDGIVTHIICIQVFTEAKIDLYSVSYPVFKETCKKQFDQVTGKYSPKSGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S064</accession>
    <name>A0A124S064_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_025691</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01006714">
        <property type="protein sequence ID" value="KVH55027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH55027">
        <property type="protein sequence ID" value="KVH55027"/>
        <property type="gene ID" value="Ccrd_025691"/>
    </dbReference>
    <dbReference type="OMA" id="YIWIEEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000004">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.30:FF:000003">
        <property type="entry name" value="Os04g0303100 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000217">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g53430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF235">
        <property type="entry name" value="OS01G0783900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="14">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="15">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="390"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="14">
        <location>
            <begin position="664"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="889"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="15">
        <location>
            <begin position="912"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH55027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1223" mass="136580" checksum="4721D430E479B8A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAU0</accession>
    <name>A0A124SAU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AB-hydrolase YheT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005372">
        <property type="protein sequence ID" value="KVH88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAU0"/>
    <dbReference type="STRING" id="59895.A0A124SAU0"/>
    <dbReference type="Gramene" id="KVH88552">
        <property type="protein sequence ID" value="KVH88552"/>
        <property type="gene ID" value="Ccrd_026511"/>
    </dbReference>
    <dbReference type="OMA" id="HIEWYSE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF95">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="4">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="44650" checksum="99BD73F20C09579D" modified="2016-04-13" version="1">METAAGDFVSPYKLLLRALTLIPISHYLLLAFFALIVFVYNLLEIHILQDIISGFGGGHVSLTFNSSSDLYREVISKCHLLYGRYVATAWLSSPHLQTILLNVLVKTPSFSYKREIFRTSDGGTVALDWLMNSDVLETSFQINGTNTVADIPLVIYIRKIAYAMAKHGWNVVVCNHRGLGGVPLTSECFYTAGKSDDLGEVVNHLHRTQPETPIYAVGTSLGANILVKYLGEEGVNVPLVGAASISNPWDLLIGDRFFTRAIMQRFYNRVLGNSLKGAAKLHQEVYARLSDWEGIEKSIDAFHRWASSARLVTNVSVPLLCLNAIDDPVCTDEAIPWDECRKNKNIVLATTKHGGHIAFFEGTSGKDLWIRVVEEYLSNLHASSIRKQQMQKFKDLSSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBC4</accession>
    <name>A0A124SBC4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBC4"/>
    <dbReference type="STRING" id="59895.A0A124SBC4"/>
    <dbReference type="Gramene" id="KVH90207">
        <property type="protein sequence ID" value="KVH90207"/>
        <property type="gene ID" value="Ccrd_007803"/>
    </dbReference>
    <dbReference type="OMA" id="IFAAFNE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176107" evidence="5">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="309" mass="33394" checksum="0E94E3D5D96D47F7" modified="2016-04-13" version="1">MGCLLSVINILCLLILPFSFVAADGSSAVGVNYGMIADDLPPPPQVVSLLKSRNIKRVPVGNEVLPGDLSIFVFPAIKNLNAALESVNLGQIPVSTAASISVLGSSYPPSAGDFRGDMKPIMQDLTGFLAGKGFPLLVTAYPYFSYVSDPNSISLSYVLFNSSDVVVKDGDLGYTNMFDAMVDAVYSALEKIGAGSVEVVICETGWPSNGNGDFTTIDLAQTYNQNLVKHVSSSGTPKKPNKNVETYVFALFNEDLKPAGVEQNFGVQKFHFVVAYLPFCLRIGTSSKTELYRTKDLDMTCYLYGFWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCC4</accession>
    <name>A0A124SCC4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamyl-tRNA reductase</fullName>
            <ecNumber evidence="3 9">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_004572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP(+) = L-glutamyl-tRNA(Glu) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="3 9"/>
    <dbReference type="EMBL" id="LEKV01004775">
        <property type="protein sequence ID" value="KVH93370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCC4"/>
    <dbReference type="STRING" id="59895.A0A124SCC4"/>
    <dbReference type="Gramene" id="KVH93370">
        <property type="protein sequence ID" value="KVH93370"/>
        <property type="gene ID" value="Ccrd_004572"/>
    </dbReference>
    <dbReference type="OMA" id="CVYNVDD"/>
    <dbReference type="OrthoDB" id="424281at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05213">
        <property type="entry name" value="NAD_bind_Glutamyl_tRNA_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.30:FF:000001">
        <property type="entry name" value="Glutamyl-tRNA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000031">
        <property type="entry name" value="Glutamyl-tRNA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="entry name" value="Glutamyl-tRNA reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000744">
        <property type="entry name" value="PRK00045.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43120:SF17">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43120">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="Glutamyl tRNA-reductase catalytic, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="Glutamyl tRNA-reductase dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA reductase N-terminal" evidence="12">
        <location>
            <begin position="123"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="11">
        <location>
            <begin position="288"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation" evidence="10">
        <location>
            <begin position="440"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH93370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="564" mass="62437" checksum="4A5F3947CF8E7C87" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCZ2</accession>
    <name>A0A124SCZ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCZ2"/>
    <dbReference type="STRING" id="59895.A0A124SCZ2"/>
    <dbReference type="Gramene" id="KVH95290">
        <property type="protein sequence ID" value="KVH95290"/>
        <property type="gene ID" value="Ccrd_002640"/>
    </dbReference>
    <dbReference type="OMA" id="APHIRRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF114">
        <property type="entry name" value="OS03G0115700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="36277" checksum="15ADF8E638F181F7" modified="2016-04-13" version="1">MLETVKYLIGSAGPSGYGSKSTAEQVTDNSVDLHSSTAIITGATSGIGAETARVLAKRGARLVIPARNLKVAEESKARIASEFPAAQILVMPLDLSSLKSVRSFVSDFEALNLPLNLLINNAGKFSYDHGISEDGIEMTFATNYLGHFLLTKLLLKKMIATAKTTGIQGRIVNVSSGIHTWFSGDLIRSLGQITRDKSHYDATRAYAISKLANVLHTKELARRLQQMEANVTVNCVHPGVVRTGLTRDREGFITDFVFFLTSKFLKTIPQAAATTCYVATHPELRNVSGKYFADCNEASNSKIGCNPKEGVRLWSFSEIMVSTDWKSVFGVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEJ7</accession>
    <name>A0A124SEJ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAK-box/P21-Rho-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEJ7"/>
    <dbReference type="STRING" id="59895.A0A124SEJ7"/>
    <dbReference type="Gramene" id="KVI00346">
        <property type="protein sequence ID" value="KVI00346"/>
        <property type="gene ID" value="Ccrd_021336"/>
    </dbReference>
    <dbReference type="OMA" id="VARHEMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325:SF20">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="186" mass="19991" checksum="F0A3FC6D9E0927BD" modified="2016-04-13" version="1">MGTAVKGLLKGLRYISEIFEADNEKEQEIQIGMPTDVKHIAHIGCDGPSTNAPSWVRTNVPHLFNMNDFQGSESGSSDLGGSKDSMSSQTRRGKSKQPKKHGAGGSVGSSPDIEPRTRRNRNSSGDSPMNETSRPRRTKNSGTGGESPSQEPGAKKTRKKKVGSNDGNTRPSRPKNRDPSTTDNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFM9</accession>
    <name>A0A124SFM9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pseudouridine synthase/archaeosine transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002332">
        <property type="protein sequence ID" value="KVI03751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFM9"/>
    <dbReference type="STRING" id="59895.A0A124SFM9"/>
    <dbReference type="Gramene" id="KVI03751">
        <property type="protein sequence ID" value="KVI03751"/>
        <property type="gene ID" value="Ccrd_017951"/>
    </dbReference>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="6">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="240" mass="26841" checksum="F18E3ACE65346002" modified="2016-04-13" version="1">MLIERMTMGSSFRFVDRSTLLDNRQICKEILSAVSSDLAVLPLNSATFRSVVEMRPLDEAETTQVFEKLFKFTGNNLKNIVESPSHEGLDKNPGRYCFRLHKNRVYYVSESLVKRATNIKRENLVALGTNIGKFTKSGKFHLTIQALNLLAANAKHKVWLKPTSEMSFLYGNDVVKGGLGRITDNINAYDGVVVFSMSDVPLGFGIAAKSTQDCRKMDPNGLVVIRQADTGEFLRNQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG13</accession>
    <name>A0A124SG13_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001893">
        <property type="protein sequence ID" value="KVI04967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG13"/>
    <dbReference type="STRING" id="59895.A0A124SG13"/>
    <dbReference type="Gramene" id="KVI04967">
        <property type="protein sequence ID" value="KVI04967"/>
        <property type="gene ID" value="Ccrd_016712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46215:SF15">
        <property type="entry name" value="DIRIGENT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46215">
        <property type="entry name" value="DIRIGENT PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008191693" description="Dirigent protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="404" mass="40204" checksum="24FD1526C01DA0E3" modified="2016-04-13" version="1">MAISTSAIFKTTICILFLTRSVQSSYGTRILIDTTNDLPPALDDPLPTNQPGTTGSIGEIDTPHEDPTASLPSGQIPATVAPAPVVSPAVPLPATPIIKTPATNVAPVAGATQAGGTGAIGATPAGGAGAIGATPAGGAGAAGATKAGGSGAGVGAVATGGGAVAAGAGHPTLSFFMHDVLGGSQSTSRVVTGIVASSSANVVPFSTPNSQVFPITGGVPLNDINGIVNNNNLPYLAGFNGNNPNNPNANTVLQNTGNNNVGNGGNNLPFVAAGQLPAGITLQQLMFGSITVIDNEITEGHELGTGVLGRGQGFYLSSSLDGSSHTFALTTLFHGSDHEVEDTISFFGVHRTASEVSHIAVIGGTGKYEEAKGYATIESLPQVDEHTTDGVETIVHVNIYLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG65</accession>
    <name>A0A124SG65_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_016251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001872">
        <property type="protein sequence ID" value="KVI05417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG65"/>
    <dbReference type="Gramene" id="KVI05417">
        <property type="protein sequence ID" value="KVI05417"/>
        <property type="gene ID" value="Ccrd_016251"/>
    </dbReference>
    <dbReference type="OMA" id="YKQHSCP"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000082">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000292">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057623">
        <property type="entry name" value="PUB12-19-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF52">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25368">
        <property type="entry name" value="PUB10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="406"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="488"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="642" mass="70386" checksum="9E3EA3922A012E8B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGV4</accession>
    <name>A0A124SGV4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGV4"/>
    <dbReference type="Gramene" id="KVI07576">
        <property type="protein sequence ID" value="KVI07576"/>
        <property type="gene ID" value="Ccrd_014103"/>
    </dbReference>
    <dbReference type="OMA" id="TSMANCQ"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.80:FF:000002">
        <property type="entry name" value="AT-hook motif nuclear-localized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014476">
        <property type="entry name" value="AHL15-29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100:SF51">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016021">
        <property type="entry name" value="ESCAROLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="8">
        <location>
            <begin position="60"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="25879" checksum="9A52A324B11220A8" modified="2016-04-13" version="1">MADFDDGDHQKHGRYLHHLLEDASTDGDEGSGGPTRRCRGRPPGSKNKPKPPVILTRESPNALRSHVLEVSAGADIVDSLSVFARRRGRGVSVLSGTGNVADVTLRQPADPSGNAVTLHGRFEILTISGTVLPPPAPPNAGGLSIFLAGGQGQVVGGIPVGPLMASSPVVLMAASFANAVFERLPVEEDVEEDGGSGAQVQPAASQCSEVTSGGGGGSGVSLFNTVAAGNNNGGSDYPYSGDVMGWGSNARTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH39</accession>
    <name>A0A124SH39_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Late embryogenesis abundant protein, LEA-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001138">
        <property type="protein sequence ID" value="KVI08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH39"/>
    <dbReference type="STRING" id="59895.A0A124SH39"/>
    <dbReference type="Gramene" id="KVI08342">
        <property type="protein sequence ID" value="KVI08342"/>
        <property type="gene ID" value="Ccrd_013299"/>
    </dbReference>
    <dbReference type="OMA" id="MSEKQSH"/>
    <dbReference type="OrthoDB" id="1889094at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF61">
        <property type="entry name" value="OS01G0574800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="7">
        <location>
            <begin position="114"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="238" mass="27116" checksum="77C28224171F964E" modified="2016-04-13" version="1">MSAPDQPHLNGAYYGPSIPPPTKKSKSYHRPGRGGGSSCNPFSWCCSCLCGCVFNLVFQILITILVLLGIAVLVFWLIFRPNAPKFHVNDAVLTQFNLSPDNNTLYYNLAVNMTFRNPNRRIGIYYDKIQANAEYHDRRFATRDLETFYLGHKKEKDVGTVFSGSQVVVLGDDRSRYDSERSDGVYYIDLKLRLRIRLKVGWAKPKFKPRFECDLRIPMGSGGRAQGGFQRTKCDVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH86</accession>
    <name>A0A124SH86_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_012869</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:18945"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001091">
        <property type="protein sequence ID" value="KVI08746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH86"/>
    <dbReference type="STRING" id="59895.A0A124SH86"/>
    <dbReference type="Gramene" id="KVI08746">
        <property type="protein sequence ID" value="KVI08746"/>
        <property type="gene ID" value="Ccrd_012869"/>
    </dbReference>
    <dbReference type="OMA" id="WVSQIWI"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000002">
        <property type="entry name" value="Prolyl 4-hydroxylase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF123">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="292" mass="32561" checksum="D1D422758EB7C620" modified="2016-04-13" version="1">MASKGRLHPRGPSRNSSSPTLIFSILIICLFFILILLALGILSIPSTSRNYPNAHDLSSIVHRITNADRSEGSDGRVDHWAEVISWEPRAVIYHNFLSQDECEHLIKIAKPHMEKSTVVDSVTGKSKDSRVRTSSGTFLERGQDETVRAIEKRIADFTFLPVEHGEGLQVLHYEVGQKYEPHYDYFLDDYNTKNGGQRMATVLMYLSDVEEGGETVFPSAKGNISAVPWWNELSECGKGGLSVKPKMGDALLFWSMKPDASPDPSSLHGGCPVIKGNKWSSTKWIRINPYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI60</accession>
    <name>A0A124SI60_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding, integrase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000060">
        <property type="protein sequence ID" value="KVI11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SI60"/>
    <dbReference type="Gramene" id="KVI11672">
        <property type="protein sequence ID" value="KVI11672"/>
        <property type="gene ID" value="Ccrd_009928"/>
    </dbReference>
    <dbReference type="OMA" id="CHVESEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039622">
        <property type="entry name" value="MBD10/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33729:SF20">
        <property type="entry name" value="DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33729">
        <property type="entry name" value="METHYL-CPG BINDING DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="36553" checksum="7029BBB24064EA75" modified="2016-04-13" version="1">MNGMGRMLSEKLLLCTTLEVNPVQKFLPKKGGTPKKNEIVFTAPTGEEISTRKQLDQYLKAHPGGPKISEFDWGSGETPRRSARISEKVKVSPPPPETEPVPKRAKRSSKKDKKQKPEEETPEKENNPEKAAEGEDVDMQEAEKTSFEKQKEEAPVKTIVEDSEKQEEKDKIVPKEKAEKDEAPEDKPAKEVEDTCENPKMPLLEDEAKSVNEINKEVVADVNEKDQDKAENDGGSVIAVGXXXXXXXAHDQDKVENDGGSVIAVGAKEEIPDAHDQDKAENDGGTATATATATVTVTVTTEGQKGNVGDKEPETNKQVEATVENGCHVESEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VRI4</accession>
    <name>A0A103VRI4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="5">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01006677">
        <property type="protein sequence ID" value="KVH58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VRI4"/>
    <dbReference type="STRING" id="59895.A0A103VRI4"/>
    <dbReference type="Gramene" id="KVH58785">
        <property type="protein sequence ID" value="KVH58785"/>
        <property type="gene ID" value="Ccrd_025665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="20339" checksum="230B9D9120A70459" modified="2016-04-13" version="1">MEALKAARDVVSKQKMITSAFDDECLKLHQAVGTEAPEQDASIAGSSNIDLLHPLTMPVGSSVQTPELFKGSLKGYQVKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLSNWVDEISRFCPDLKAFPYWGGIQERTLRPDWRFRQIDLVGILPLDLVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103W796</accession>
    <name>A0A103W796_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006606">
        <property type="protein sequence ID" value="KVH67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103W796"/>
    <dbReference type="STRING" id="59895.A0A103W796"/>
    <dbReference type="Gramene" id="KVH67065">
        <property type="protein sequence ID" value="KVH67065"/>
        <property type="gene ID" value="Ccrd_025628"/>
    </dbReference>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="130"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="619" mass="70504" checksum="505CC88A1877B397" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBL0</accession>
    <name>A0A103XBL0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005897">
        <property type="protein sequence ID" value="KVH87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBL0"/>
    <dbReference type="STRING" id="59895.A0A103XBL0"/>
    <dbReference type="Gramene" id="KVH87721">
        <property type="protein sequence ID" value="KVH87721"/>
        <property type="gene ID" value="Ccrd_024993"/>
    </dbReference>
    <dbReference type="OMA" id="VFMQPPL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF18">
        <property type="entry name" value="DNA-BINDING PROTEIN MNB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="65" mass="7099" checksum="A0204C8633F5AE6F" modified="2016-04-13" version="1" fragment="single">MKGGKSSGGTRKADTKLAVKKTQAKGKAVKDPNKPKRPASAFFLFMEEFRKQFKEENPGNKSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBW1</accession>
    <name>A0A103XBW1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUMO-conjugating enzyme Ubc9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005744">
        <property type="protein sequence ID" value="KVH87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBW1"/>
    <dbReference type="STRING" id="59895.A0A103XBW1"/>
    <dbReference type="Gramene" id="KVH87876">
        <property type="protein sequence ID" value="KVH87876"/>
        <property type="gene ID" value="Ccrd_024809"/>
    </dbReference>
    <dbReference type="OMA" id="FIQGPRE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="81" mass="9176" checksum="6E60561DABFB20EC" modified="2016-04-13" version="1">MAGGVALGRLTEERKAWRKNHPYGWRPAITVRQLLVGIQDLLDTPNPASPAQSDLHGLFTKNLVEYKKMVRHQAKLYPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEQ4</accession>
    <name>A0A103XEQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prenyltransferase/squalene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005221">
        <property type="protein sequence ID" value="KVH89383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEQ4"/>
    <dbReference type="STRING" id="59895.A0A103XEQ4"/>
    <dbReference type="Gramene" id="KVH89383">
        <property type="protein sequence ID" value="KVH89383"/>
        <property type="gene ID" value="Ccrd_008629"/>
    </dbReference>
    <dbReference type="OMA" id="HFHIKES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042300">
        <property type="term" value="F:beta-amyrin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF71">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="5">
        <location>
            <begin position="453"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="604" mass="68845" checksum="5AE4CC70447BBC22" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFB2</accession>
    <name>A0A103XFB2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_008291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01005157">
        <property type="protein sequence ID" value="KVH89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFB2"/>
    <dbReference type="STRING" id="59895.A0A103XFB2"/>
    <dbReference type="Gramene" id="KVH89715">
        <property type="protein sequence ID" value="KVH89715"/>
        <property type="gene ID" value="Ccrd_008291"/>
    </dbReference>
    <dbReference type="OMA" id="HTVRTHS"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="12">
        <location>
            <begin position="89"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="13">
        <location>
            <begin position="395"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="57370" checksum="5F1DB427E5A09CC7" modified="2016-04-13" version="1">MPDSPSDRERRTSLPNFLLSVKLKYVKLGYHYLISHFMYLLLIPLLAVVSVHLSTLTSQDLVHLWHQLRFNLVTVIVCSTLIVFLATLYFMSRPKKVYLLDFACYKPEDAHIVSRETFMERSALAGTFSEENLAFQKKILERSGLGQNTYFPEAVLQVPPNPSMAEARKEAEMVMFGAIDELLAKTGVKAKDIGILIVNCSLFCPTPSLSSMVVNRYKLRGNVLSYNLGGMGCSAGLISIDLAKQLLQVNPNSYALVVSMENITLNWYFGNNRSMLVSNCLFRMGGAAILLSNRSSDRSRSKYQLLHTVRTHKGADDRCYSCVFQEEDDEKKIGVALSKDLMAVAGEALKTNITTLGPIVLPMSEQLLFFVTLVGRKVFKMKIKPYIPDFKLAFEHFCIHAGGRAVLDELEKNLELSDWHMEPSRMTLYRFGNTSSSSLWYELAYCEAKGRIQKGDRSWQIAFGSGFKCNSAVWRALRTIDPAKEKNPWINEIHEFPVHVPRITKIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFB8</accession>
    <name>A0A103XFB8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fringe-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005174">
        <property type="protein sequence ID" value="KVH89686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFB8"/>
    <dbReference type="STRING" id="59895.A0A103XFB8"/>
    <dbReference type="Gramene" id="KVH89686">
        <property type="protein sequence ID" value="KVH89686"/>
        <property type="gene ID" value="Ccrd_008320"/>
    </dbReference>
    <dbReference type="OMA" id="PSMDRIQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000061">
        <property type="entry name" value="AT4g00300 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49822" checksum="5F9F226B24088C26" modified="2016-04-13" version="1" fragment="single">MATSTLKPTSSTLCTTLVLVSILIMFIVFSFSKQRNSLRTDFFPVTARQSLPQPDTNISHIVFGLVGSTKAWTYRKSYIESWWRPNVTRGYLYLDTAPTNDLLPWSPNSPPFRISDNITKLLDETKHVAPIMVRMVHAVIEVFREEREGVRWYIMGDDDSIFFVDNLVDVLSEYDHNKYIYIGGHSESIMSNQIFSYDMGFGGAGLIMSYPLAKMVQKNIEDCFKRYPYLNSADLILMTCVNDFGVSVTTHQGLHQMDLRGDVSGFLSSHPKAPLLSLHHFDHIDPIFRSMDSFQSAKHLMKAAKVDQTRLVQQTICYNRQLKWSFSVSWGYSIHVYEIVIPRSILKVPLETFKPWLWNSQPPYYIFNTRPLSNDPCETPHVFSFDSVENVSENEVVTNYIRVASRGLPTCQFAGNHSADLVSRIQVVSPTAKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFM6</accession>
    <name>A0A103XFM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005141">
        <property type="protein sequence ID" value="KVH89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFM6"/>
    <dbReference type="Gramene" id="KVH89777">
        <property type="protein sequence ID" value="KVH89777"/>
        <property type="gene ID" value="Ccrd_008229"/>
    </dbReference>
    <dbReference type="OMA" id="INREPFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="193" mass="22477" checksum="28ED0D02D4CE0562" modified="2016-04-13" version="1">MHRHLESCVMKAKHVRQQKLINFLPSDSSTGTNQSGFVSALNNGKLDMLKMREGIAHWITMHEHPFSIVEEEGFNLMMKRGIPEWNRVSRVTIKADAFKVYELEKKRLKDLFKKVERVSLTTDLWKSKSQKIEYMVITAHFVDLEWKLQKRVINFVHLPPPRKGANIADCILTCLREWEIEDKLGDVGNSCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGX6</accession>
    <name>A0A103XGX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGX6"/>
    <dbReference type="STRING" id="59895.A0A103XGX6"/>
    <dbReference type="Gramene" id="KVH90482">
        <property type="protein sequence ID" value="KVH90482"/>
        <property type="gene ID" value="Ccrd_007519"/>
    </dbReference>
    <dbReference type="OMA" id="VQCGREP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071483">
        <property type="term" value="P:cellular response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090351">
        <property type="term" value="P:seedling development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06171">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF45">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGF, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA polymerase sigma-70" evidence="7">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase sigma-70" evidence="8">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="549" mass="62240" checksum="51760CEA6D283AB6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHI0</accession>
    <name>A0A103XHI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005091">
        <property type="protein sequence ID" value="KVH90814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHI0"/>
    <dbReference type="STRING" id="59895.A0A103XHI0"/>
    <dbReference type="Gramene" id="KVH90814">
        <property type="protein sequence ID" value="KVH90814"/>
        <property type="gene ID" value="Ccrd_007173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="19240" checksum="2F8464F7F566F970" modified="2016-04-13" version="1">MYLTPSSELAIAALNKFEKDPQELKDIFKSGESDQEQKREFVLEGEKEEEEDDEEDDELDDENNEEEDEDEDEIEEDESGDGERKRKKRGGVGVEDKLLNIQEMKESMEDDESREYGVNKKKQVVKKMARKFGEDDEVEDDDEDDDDELGVLELAGEEDMSDVEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHS7</accession>
    <name>A0A103XHS7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat shock protein DnaJ, cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005086">
        <property type="protein sequence ID" value="KVH90965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHS7"/>
    <dbReference type="STRING" id="59895.A0A103XHS7"/>
    <dbReference type="Gramene" id="KVH90965">
        <property type="protein sequence ID" value="KVH90965"/>
        <property type="gene ID" value="Ccrd_007015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000427">
        <property type="term" value="C:plastid-encoded plastid RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042793">
        <property type="term" value="P:plastid transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32318" checksum="E249C38F6FA2DE82" modified="2016-04-13" version="1">MSSSLPLTFNSLISWQKSSRIPSEFNNNAIGFPNFNKPTSLSLSKSHICFTFNNNSSEYEREETRWLREEQRWMREEQRWIREEQRWEAERESLLNEIKTLKLQIEELRREGGNTSVSNVAKLLHVLKKEVNQISDSGSSAAPLVVEAAAAAAAVEDAEEVVVKEVIKVAEETKGRNKDKEVKKKRAMLRVGSEGENGVAVTSVTQVPEILSRVVKEYVEPDVYDNRVFLLGENRWEDSSRLKNRNKQDSQFLEWVGEDTKCPYCEGIGHSICDVCQGTGFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ15</accession>
    <name>A0A103XJ15_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XJ15"/>
    <dbReference type="Gramene" id="KVH91577">
        <property type="protein sequence ID" value="KVH91577"/>
        <property type="gene ID" value="Ccrd_006391"/>
    </dbReference>
    <dbReference type="OMA" id="CNSHKGI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF550">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="493" mass="54208" checksum="4DBA98341D7896F4" modified="2016-04-13" version="1">MFPWAIAIQRPQLDNDIEIEMMHENSVLDPGGEMEVSFGYQCNTTEGYDIPTGKKLQRNNSSFSCLSGAAISANATLANTNICNGLISSEILPSIDSPKSFRRIPSSPSFSKLDLLSSSFQSSMSNLSCSPSTPETLDFDSFLSKSLSAPSRNEDFLNAIEVQVAGGAAGEDRVQAVCSEENGWLFCAIYDGFNGRDAADFLAGTFYETIRYNLNSLDMEFDSFKPDDYFLGDGNMGSEKRSLSPKTRVLDSLQHALNQAENDFLYMVEQEMEDRPDIVSVGSCVLVGLLHGKDLYILNLGDSRAVLATDDDETTIEDFKGLKAVQLTDSHTVDNESERNQLISEXPDDPKTIMHGKVKGKLKKVLNDALMGILRVRNLQSPPYVSVQPSLYMHEVSSSDHFVIFGSDGLFDFFTNDEAVKLVHSYISTKPSGDPAKYLLEQLVLKAACSAGFSTEELMSVPAGRRRKYHDDVTVIVIILGTNKRTSKASTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK53</accession>
    <name>A0A103XK53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004861">
        <property type="protein sequence ID" value="KVH92084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XK53"/>
    <dbReference type="Gramene" id="KVH92084">
        <property type="protein sequence ID" value="KVH92084"/>
        <property type="gene ID" value="Ccrd_005886"/>
    </dbReference>
    <dbReference type="OMA" id="YTWENTH"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF38">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE, AMP-BINDING ENZYME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="41803" checksum="0DFD1C4D392C71C4" modified="2016-04-13" version="1">MQLLQSTYDTYHINPKQFSSYQATTINVNKIFKKSYARFHQGSLTAANRYCKVQCQNSPQETHLVESRERSLNQDSWKPPEGVVRGSVNYVPLSPISFLERAAEVYRNRTSMIYGSIKYTWEETHHRCLKLASALNRLGVSRGDVATLAPNIPAAQELHFAIPMAGAIICPLNTRLNPSMISKLLEHSEAKILFVDYQLLQIAKDALSLLNNTHSKAPRLFIISEPNYKSSLTLTHKYDYESLVESGVIEFSVVRXHDECDPISLNYTSGTTSSPKGVVXSHRGAYLNSLATMFIHGVREMPTYLWSLPMFHCNGWCFSWGMAIVGGTNXKFNWFVRGLVVLLSIEDGIQVDLFNEMMDYGSKLEARPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLY0</accession>
    <name>A0A103XLY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004796">
        <property type="protein sequence ID" value="KVH93075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLY0"/>
    <dbReference type="Gramene" id="KVH93075">
        <property type="protein sequence ID" value="KVH93075"/>
        <property type="gene ID" value="Ccrd_004888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34287:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34287">
        <property type="entry name" value="OS06G0551500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="65" mass="7482" checksum="52A147C7E8D3680A" modified="2016-04-13" version="1">MDASEFNLDYEPSALWSPPISPPKFFLTSPAGFICSVDEMLKKFHSIRETKISRFKKFISCCFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM82</accession>
    <name>A0A103XM82_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004777">
        <property type="protein sequence ID" value="KVH93348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM82"/>
    <dbReference type="STRING" id="59895.A0A103XM82"/>
    <dbReference type="Gramene" id="KVH93348">
        <property type="protein sequence ID" value="KVH93348"/>
        <property type="gene ID" value="Ccrd_004594"/>
    </dbReference>
    <dbReference type="OMA" id="WMTASAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="13789" checksum="25711B5E2B47198B" modified="2016-04-13" version="1">MEKGFNGHFDDDGRIRRTGTLMSASAHIITTVVGSGVLSLSWCFAQLGWITGIVLLVAFAIITWFTCLLLADCYRSPDPVTGTRNYNYMQAVKANLGGVSYRFCGLSQYGTQVGGTIGYTITSAISMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMV3</accession>
    <name>A0A103XMV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004614">
        <property type="protein sequence ID" value="KVH93723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMV3"/>
    <dbReference type="STRING" id="59895.A0A103XMV3"/>
    <dbReference type="Gramene" id="KVH93723">
        <property type="protein sequence ID" value="KVH93723"/>
        <property type="gene ID" value="Ccrd_004224"/>
    </dbReference>
    <dbReference type="OMA" id="GITHLPF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01189">
        <property type="entry name" value="ccmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43499">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43499:SF1">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="31975" checksum="71350A994994E7B3" modified="2016-04-13" version="1">MSLRRRPLPRLLLNNVSCMRNAQQILRHTNISIHDGGALVLTGANGSGKSTFLHMLAGFSKPSSGEILWDGHDITESGVFHQYKLQLNWLSLKEAIKSNFTVLDNVQWFEVLEYKQGKSLPALEFMGLGRLANEKARMLSMGQRKRLQLARVMAMDRPIWLLDEPSVALDDEGVKLLEQMIADHRSQGGIVIVATHLPIQIQDAMILRLPPSLVWSSSELKPGLVVVAAQAFRLCLPSVASLPLLPSPSVASLPPLPSLRRQSSASAFPPSPASIDCSGDQQEGGKERRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPG3</accession>
    <name>A0A103XPG3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Helicase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_003645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPG3"/>
    <dbReference type="STRING" id="59895.A0A103XPG3"/>
    <dbReference type="Gramene" id="KVH94289">
        <property type="protein sequence ID" value="KVH94289"/>
        <property type="gene ID" value="Ccrd_003645"/>
    </dbReference>
    <dbReference type="OMA" id="CTFIQQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000034">
        <property type="entry name" value="Protein CHROMATIN REMODELING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="404"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="738"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="904"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1144" mass="127954" checksum="6E408E973EC0D7AE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ85</accession>
    <name>A0A103XQ85_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004504">
        <property type="protein sequence ID" value="KVH94906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ85"/>
    <dbReference type="STRING" id="59895.A0A103XQ85"/>
    <dbReference type="Gramene" id="KVH94906">
        <property type="protein sequence ID" value="KVH94906"/>
        <property type="gene ID" value="Ccrd_003029"/>
    </dbReference>
    <dbReference type="OMA" id="EDAEHNS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008004">
        <property type="entry name" value="OCTOPUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31659">
        <property type="entry name" value="PROTEIN: UPF0503-LIKE PROTEIN, PUTATIVE (DUF740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31659:SF9">
        <property type="entry name" value="PROTEIN: UPF0503-LIKE PROTEIN, PUTATIVE (DUF740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05340">
        <property type="entry name" value="DUF740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="619" mass="69658" checksum="29C47C15F98764AB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRP5</accession>
    <name>A0A103XRP5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FLZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FLZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRP5"/>
    <dbReference type="STRING" id="59895.A0A103XRP5"/>
    <dbReference type="Gramene" id="KVH95644">
        <property type="protein sequence ID" value="KVH95644"/>
        <property type="gene ID" value="Ccrd_002314"/>
    </dbReference>
    <dbReference type="OMA" id="KVTHIFC"/>
    <dbReference type="OrthoDB" id="685855at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044585">
        <property type="entry name" value="FLZ10/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007650">
        <property type="entry name" value="Zf-FLZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46868">
        <property type="entry name" value="FCS-LIKE ZINC FINGER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46868:SF3">
        <property type="entry name" value="FCS-LIKE ZINC FINGER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04570">
        <property type="entry name" value="zf-FLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51795">
        <property type="entry name" value="ZF_FLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLZ-type" evidence="6">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FLZ-type" evidence="4">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="42534" checksum="A11DBA13E13376AE" modified="2016-04-13" version="1">MLRKRTRSHQKDQQNMGQAQHLIPDSYSNESCYSNSDAFLKQKHKTNSFFTVPGLFVGLNPKTSESDSVRSPTSPLDFKVFSKPNLGNLPTRASKQNEATQKSWDCNKVGLSIIESLEDEMKPSAGKILRSSDSKNILFAPQMRILNNPSLKTASFDPFDSLSNSLPKNYAIFPFTQIKKSNPKLINPLAQEPFAKFWSHSLDSANLGANLTSLTTRPTNLSTGLSNGQNLGKDLVASLSASEIELSEDYTCVRKHGPNPKTTHIFGDCILERHDDEFIAKSPKCEENEIKPSEVLTSYLSDDFLSFCYSCKKKLEGEDIYMYRGEKAFCSWNCRSEEILIEEEMEKNNREAGASSQIEIIPKLESCEELFETSMFIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRU0</accession>
    <name>A0A103XRU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004379">
        <property type="protein sequence ID" value="KVH95669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRU0"/>
    <dbReference type="STRING" id="59895.A0A103XRU0"/>
    <dbReference type="Gramene" id="KVH95669">
        <property type="protein sequence ID" value="KVH95669"/>
        <property type="gene ID" value="Ccrd_002242"/>
    </dbReference>
    <dbReference type="OMA" id="IVASHAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021924">
        <property type="entry name" value="DUF3537"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31963:SF26">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31963">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12056">
        <property type="entry name" value="DUF3537"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="49763" checksum="9EB992FDEC5AD369" modified="2016-04-13" version="1">MSDHSPTPIEHESKEEPTQIKTPLILHDSDQTQNLNEANQDDNEEEEEEGRTHLDKSLQRLNFYLCLLGFDQSSVIRCVISWVMFLVIGVAIPVVVLLLTTNCLSCDLYQINGFELVIVASHACLAAVALLCLSHNLRKYGIRKFLFVDQYSGHVERFSKEYIQKISVSKYPIPVLISVPFPGIYTLASIVGSAMYDLEDCTGNHQCYVHAPSIVVEVFQCPCSSDVIIHFDDYGKLLETETDVLVFIEEHARLRHDLSKISHRFRIYLILVFTVVTSSQFAMLFQITEFSDKVTFINGGDFAVSSIAQVVGLILCLNAAAKISHRAQGIAALATRWHALASCGPDDMSHMRLSNRAMSTVSSESDLEAMNYIPLPTNTQLASYLSSYHRRQAFVMYLQNNPGGITLYGWTVDRGLINTIFFIELSLVLFVLGRTTVFTSESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS19</accession>
    <name>A0A103XS19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004375">
        <property type="protein sequence ID" value="KVH95841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS19"/>
    <dbReference type="Gramene" id="KVH95841">
        <property type="protein sequence ID" value="KVH95841"/>
        <property type="gene ID" value="Ccrd_002063"/>
    </dbReference>
    <dbReference type="OMA" id="TLIGMSH"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057444">
        <property type="entry name" value="Znf-CCCH_AtC3H23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF90">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25512">
        <property type="entry name" value="zf-CCCH_AtC3H23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="44552" checksum="644041BE4B73EE77" modified="2016-04-13" version="1">MSSGSCLEQHKFHSSHHQLYHNLANNNKSIRDIDIPPRKLLGRRASAASAETFLDNMYQQQQNESPKVLPEDTLFKRFLPYNSGVDSDDEDSDPYSGDHFRIYEFKVRKCTRSRSHDWTDCPFAHPGEKARRRCPRRYNYLGTVCADFRRGSCSRGDLCEFAHGVFECWLHPSRYRTEACKDGKNCQRKICFFAHTPRQLRVLPPAEAAVSGKKYPSETCHCCAHCRCHSGIHHTNSPTSTLNIDQLDNLSPPASPPFSPARSGAGFSPISRFADRMARAESFGMTQFGNSSSIQKDSMSMNEIMSNQSVLNDLMRSMEAMTVEENDQFPNVKFNGGSGCVDGGDQYPEFDHNHLSDSGHSDLSGSFSMSSNSKQNLYNENLISGPDFGWVNDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSP5</accession>
    <name>A0A103XSP5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSP5"/>
    <dbReference type="STRING" id="59895.A0A103XSP5"/>
    <dbReference type="Gramene" id="KVH96134">
        <property type="protein sequence ID" value="KVH96134"/>
        <property type="gene ID" value="Ccrd_001803"/>
    </dbReference>
    <dbReference type="OMA" id="YNTIEIM"/>
    <dbReference type="OrthoDB" id="1565598at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17168" checksum="33722048F98048F4" modified="2016-04-13" version="1">MAVVTSELEVPSSVSASKLFKAFLDFRNLAPKVEPESFKAIDYIKGDGGIGTIQQTTFVDGSKTKLTVDAIDHTNFSLSTTIFEGGEWMDNLESATYHAKFVPSTTNDGSTYKVSSVYKCKDPAKFTEENAKFADEYTKKTFKAIEAYIVANPNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT53</accession>
    <name>A0A103XT53_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="6">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Extracellular space</location>
            <location evidence="6">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01004323">
        <property type="protein sequence ID" value="KVH96374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT53"/>
    <dbReference type="STRING" id="59895.A0A103XT53"/>
    <dbReference type="Gramene" id="KVH96374">
        <property type="protein sequence ID" value="KVH96374"/>
        <property type="gene ID" value="Ccrd_001539"/>
    </dbReference>
    <dbReference type="OMA" id="NIREKEW"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989405" description="Xyloglucan endotransglucosylase/hydrolase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="37908" checksum="62ED4CE30CEE475E" modified="2016-04-13" version="1">MDSLHLILSLLCSVFALVSGYSRTLQISSFDEGYSHLFGGNNLQVLKDGKSVHLSLDERTGSGFVSQDLYLHGFFSASIKLPADYTAGVVVAFYMSNGDTYEKNHDEIDFEFLGNIRGKEWRIQTNIYGNGSTNVGREERFGLWFDPSYDYHQYSILWTDDRIIFYVDNVAIREIKRTESMGKDFPSKPMTLYATIWDASEWATNGGKYKVNYKYAPYIAEFSDFVLHGCTVDPMELSTLKCDTTPNSNSILADLTPAERIKMESFRKKHLQYSYCYDKMRYKTPPSECLVDHEEAKQLKSFDPITFGGSRCRHRSHHGRMHRQSRSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTQ8</accession>
    <name>A0A103XTQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_001172</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004234">
        <property type="protein sequence ID" value="KVH96737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTQ8"/>
    <dbReference type="Gramene" id="KVH96737">
        <property type="protein sequence ID" value="KVH96737"/>
        <property type="gene ID" value="Ccrd_001172"/>
    </dbReference>
    <dbReference type="OMA" id="QKWFFAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF93">
        <property type="entry name" value="PROTEIN OSCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="276"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH96737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="670" mass="76702" checksum="FE42704AD1F5EA23" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW92</accession>
    <name>A0A103XW92_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_023738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003812">
        <property type="protein sequence ID" value="KVH98046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW92"/>
    <dbReference type="STRING" id="59895.A0A103XW92"/>
    <dbReference type="Gramene" id="KVH98046">
        <property type="protein sequence ID" value="KVH98046"/>
        <property type="gene ID" value="Ccrd_023738"/>
    </dbReference>
    <dbReference type="OMA" id="SHEQEND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF228">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="711" mass="81308" checksum="9F36F7F31F76E5EC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX33</accession>
    <name>A0A103XX33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, Dof-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003794">
        <property type="protein sequence ID" value="KVH98513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX33"/>
    <dbReference type="STRING" id="59895.A0A103XX33"/>
    <dbReference type="Gramene" id="KVH98513">
        <property type="protein sequence ID" value="KVH98513"/>
        <property type="gene ID" value="Ccrd_023261"/>
    </dbReference>
    <dbReference type="OMA" id="PCKGREN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089">
        <property type="entry name" value="CYCLIC DOF FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089:SF1">
        <property type="entry name" value="CYCLIC DOF FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="481" mass="52975" checksum="35A7EC121772FAB2" modified="2016-04-13" version="1" fragment="single">ASAICQQYSSTFSHSKDPFLRRRQPPPLIGKFISMEATGIKLFGKNIAYQDRGRITTNLPVFSTATATATATATAAESSDGSYGEHGCFKHGHGLRREETCLKEEDSKREHSDKDQIREKKQENKSSPKAVVAESDGNPKTPITEDTDTSKTETLNNATNLQSEDLKKPDKTIPCPRCNSMDTKFCYYNNYNVKQPRHFCKSCQRYWTAGGTMRSMPVGAGRRKNKNPTSHYGFVTISKAAQIEVTASNGVHGVPSKVISFGSVSPHVDSVRASAVSCRERENGDDCSSGSSVTTSNSVTEKMQDRNGFHSHLPCIPGVSWSYNPWNSAIPIPGVCPTGYSPMSMPFYPSPYWNYIPWLPPSSHTQNQNVQSATDLNSFILGKHSRDGELINPNGSEEPKKQKSSILIPKTLRIDDPDEAAKSSIWSTLGIKNENFGPRGVFKAFQTKDEETKQHPASTTSPVLHVNPAALSRSLCFQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX78</accession>
    <name>A0A103XX78_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003787">
        <property type="protein sequence ID" value="KVH98588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX78"/>
    <dbReference type="STRING" id="59895.A0A103XX78"/>
    <dbReference type="Gramene" id="KVH98588">
        <property type="protein sequence ID" value="KVH98588"/>
        <property type="gene ID" value="Ccrd_023192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="3">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="11148" checksum="9746B19BB336FD5B" modified="2016-04-13" version="1">MAAAAIFTGEKREKERGLFRSGTEDKIAVIVGTITDDVRVHEIPCMKVLLRGPKNCCETVRHFGKAPGVPHSHTKPYVRAKGRKFEKARGRRNCRGFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXG4</accession>
    <name>A0A103XXG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003763">
        <property type="protein sequence ID" value="KVH98705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXG4"/>
    <dbReference type="STRING" id="59895.A0A103XXG4"/>
    <dbReference type="Gramene" id="KVH98705">
        <property type="protein sequence ID" value="KVH98705"/>
        <property type="gene ID" value="Ccrd_023067"/>
    </dbReference>
    <dbReference type="OMA" id="WIKEKCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33386">
        <property type="entry name" value="OS02G0740600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33386:SF5">
        <property type="entry name" value="OS02G0740600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="8821" checksum="F96FF29E3981C218" modified="2016-04-13" version="1">MALDNRYNSWADQWDPEPEYSNRYTGGKSNGASGGGIKSRVGEGFSKSKVAATTGMKKVKKGTTLGFHWIKEKCHKTSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXT9</accession>
    <name>A0A103XXT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XXT9"/>
    <dbReference type="Gramene" id="KVH98886">
        <property type="protein sequence ID" value="KVH98886"/>
        <property type="gene ID" value="Ccrd_022892"/>
    </dbReference>
    <dbReference type="OMA" id="FHAMLLY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006866">
        <property type="entry name" value="DUF627_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006865">
        <property type="entry name" value="DUF629"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF9">
        <property type="entry name" value="ECHINUS SPLICE FORM 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04781">
        <property type="entry name" value="DUF627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04780">
        <property type="entry name" value="DUF629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1643" mass="185557" checksum="8E4853FF4DAEB438" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYC1</accession>
    <name>A0A103XYC1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYC1"/>
    <dbReference type="STRING" id="59895.A0A103XYC1"/>
    <dbReference type="Gramene" id="KVH99061">
        <property type="protein sequence ID" value="KVH99061"/>
        <property type="gene ID" value="Ccrd_022695"/>
    </dbReference>
    <dbReference type="OMA" id="CLASMYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF126">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN, MFS TRANSPORTER SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="8">
        <location>
            <begin position="340"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="550" mass="59289" checksum="DC60BFF112797B29" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ48</accession>
    <name>A0A103XZ48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003485">
        <property type="protein sequence ID" value="KVH99495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ48"/>
    <dbReference type="Gramene" id="KVH99495">
        <property type="protein sequence ID" value="KVH99495"/>
        <property type="gene ID" value="Ccrd_022270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="13843" checksum="CE74133E014FCD4E" modified="2016-04-13" version="1" fragment="single">SRIFGSHCSFWTNFGVVVLCFGEWLLGFLKEKANALDETDAMVVFGGINWVMKYGNSKGLMEGGPCISPVRLVDKINSLIGQDSSSKYIIESFKTNRCFTDYSSEDDDGFQSIIEDDPFFLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ63</accession>
    <name>A0A103XZ63_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin A/B/D/E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003442">
        <property type="protein sequence ID" value="KVH99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ63"/>
    <dbReference type="STRING" id="59895.A0A103XZ63"/>
    <dbReference type="Gramene" id="KVH99554">
        <property type="protein sequence ID" value="KVH99554"/>
        <property type="gene ID" value="Ccrd_022212"/>
    </dbReference>
    <dbReference type="OMA" id="MDETMSS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20506">
        <property type="entry name" value="CYCLIN_AtCycA-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20562">
        <property type="entry name" value="CYCLIN_AtCycA_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000013">
        <property type="entry name" value="Cyclin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000167">
        <property type="entry name" value="Mitotic cyclin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="9">
        <location>
            <begin position="399"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="403"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="512" mass="58020" checksum="0F82BD4FEC59BF14" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0U2</accession>
    <name>A0A103Y0U2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003389">
        <property type="protein sequence ID" value="KVI00446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0U2"/>
    <dbReference type="STRING" id="59895.A0A103Y0U2"/>
    <dbReference type="Gramene" id="KVI00446">
        <property type="protein sequence ID" value="KVI00446"/>
        <property type="gene ID" value="Ccrd_021306"/>
    </dbReference>
    <dbReference type="OMA" id="CKKFIAI"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050262">
        <property type="entry name" value="Ribose-5P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748:SF2">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="144" mass="15905" checksum="E191A5C8BC96CCFE" modified="2016-04-13" version="1">MNLVKGCGGSLRREKVIEVCCKKLVVIVDETKLVDYVGGSRLAMSVEIVSFCWKFTTQKLQSLFEEADCVPKLCVLPKNGKAYVIDNGNFIINLYFKKDIGGLKVVDDAISRPANVVDHGMMFIDMVTTLIVAGELGARVRNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1F9</accession>
    <name>A0A103Y1F9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003285">
        <property type="protein sequence ID" value="KVI00755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1F9"/>
    <dbReference type="STRING" id="59895.A0A103Y1F9"/>
    <dbReference type="Gramene" id="KVI00755">
        <property type="protein sequence ID" value="KVI00755"/>
        <property type="gene ID" value="Ccrd_020993"/>
    </dbReference>
    <dbReference type="OMA" id="YLDQHTK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF136">
        <property type="entry name" value="ABC TRANSPORTER F FAMILY MEMBER 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="262"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="477" mass="54348" checksum="B6C3075DD7F50CF8" modified="2016-04-13" version="1">MFSRLYIESLSLTFHGHDLIVDSELELNYGRRYGLLGLNGCGKSTLLTSIGQRELPIPEHMDIFHLTREIEASDMSSLEAVMNFYERLDAMDASTAEKRAAEILNGLGFNKKMQEKKTRDFSGGWRMRIALARALFMNPTILLLDEPTNHLDFLNGVCTNIIHMQNKKLKMYTGNFDQYVQTRSELEENQMKQYKWEQDQIASMKEYIARFGHGSAKLARQAQSKEKTLAKMERGGLTEVVTRDKVLVFQFTDVGKLPPPVLQFVEVSFGYTPDNLIYKNLDFGVDLDSRVALVGPNGAGKSTLLKLMSGELVPLDGMVRRHNHLRIAQFHQHLAEKLDLEMSALAYMMSEYPGNEEEKMRAAIGRFGLTGKAQVMPMKNLSDGQRSRVIFSWLAYRQPHMLLLDEPTNHLDIETIDSLADALNEWDGGMVLVSHDFRLINQVAHEIWVCENQAVTRWQGDIMGFKEHLRRKADPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1G2</accession>
    <name>A0A103Y1G2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003259">
        <property type="protein sequence ID" value="KVI00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1G2"/>
    <dbReference type="Gramene" id="KVI00779">
        <property type="protein sequence ID" value="KVI00779"/>
        <property type="gene ID" value="Ccrd_020968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="14458" checksum="35EE229DE2F5AAF4" modified="2016-04-13" version="1">MHERYDYKVIKNVIEEPTFIEEAIDLITRSISLKGLSELIRYWIYFIRNRSTRIGAANSNSTRISFFGSTKEELAHKLDKGQDAVRCRWLTQVPSDPCEMVAYYMNSGYSHDSMGQLHLFFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3P0</accession>
    <name>A0A103Y3P0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fucosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_019774</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus</location>
            <location evidence="1 15">Golgi stack membrane</location>
            <topology evidence="1 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01002670">
        <property type="protein sequence ID" value="KVI01946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3P0"/>
    <dbReference type="Gramene" id="KVI01946">
        <property type="protein sequence ID" value="KVI01946"/>
        <property type="gene ID" value="Ccrd_019774"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000005">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="17">
        <location>
            <begin position="598"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI01946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="822" mass="93456" checksum="60B5C0C724412861" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y567</accession>
    <name>A0A103Y567_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_018968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002641">
        <property type="protein sequence ID" value="KVI02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y567"/>
    <dbReference type="STRING" id="59895.A0A103Y567"/>
    <dbReference type="Gramene" id="KVI02744">
        <property type="protein sequence ID" value="KVI02744"/>
        <property type="gene ID" value="Ccrd_018968"/>
    </dbReference>
    <dbReference type="OMA" id="MINRNTM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050762">
        <property type="entry name" value="HD-ZIP_Homeobox_LZ_Class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714:SF34">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00340">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32084" checksum="7F15C5A903D685D3" modified="2016-04-13" version="1">MGFDRVCDTGLVLGLSLNSSPSMFKPNTMGSGSGSGSTKESCVTENMPSFEPSLTLGLSGDHRDPNTSWKRLVVGGGHGGVYRQDSTVISGGGSSFSSLSVKREREVGSEESERVSNDNNYSSRVMSTTSVDDVEDDDGTVNGRKKLRLTKPQSALLEEAFELHSSLNPKQKQELARELKLRPRQVEVWFQNRRARTKLKQTELDYEHLKKCCETLRDENRRLHKELQELKALKSSQPFYMQLPAATLTMCPSCERVGDTNSATTTSKNPFTMAAKPHFFNSFTNPSAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5Y5</accession>
    <name>A0A103Y5Y5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002540">
        <property type="protein sequence ID" value="KVI03114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5Y5"/>
    <dbReference type="STRING" id="59895.A0A103Y5Y5"/>
    <dbReference type="Gramene" id="KVI03114">
        <property type="protein sequence ID" value="KVI03114"/>
        <property type="gene ID" value="Ccrd_018594"/>
    </dbReference>
    <dbReference type="OMA" id="HDMFDGP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF33">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="25216" checksum="CCAE7FC56643A0A1" modified="2016-04-13" version="1">MKNGEFLILWYYADMYLYPPGSFLVCSHQSFRRPKNLPWQRDLLEESLKAAGLPGLDNGAKLYVSNLDIGVTNEDIRELFSEIGELKRYAIHYDKSGRPNGTAEVMFARRSDAFQALNRYNNVQLDGKPMKIEIVGSKSEVPLSPRVNVVGGVNGHRTVVMMPGGGRGRGAAAFNRASGQRSRGGTVNGRGGRGRGRGGRGRGRGRKAAVDKSADELDKELENYHAMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y645</accession>
    <name>A0A103Y645_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription repressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ovate family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional repressor that regulates multiple aspects of plant growth and development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002411">
        <property type="protein sequence ID" value="KVI03214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y645"/>
    <dbReference type="STRING" id="59895.A0A103Y645"/>
    <dbReference type="Gramene" id="KVI03214">
        <property type="protein sequence ID" value="KVI03214"/>
        <property type="gene ID" value="Ccrd_018490"/>
    </dbReference>
    <dbReference type="OMA" id="MENNIRT"/>
    <dbReference type="OrthoDB" id="1928390at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025830">
        <property type="entry name" value="DNA_bnd_dom_ovate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038933">
        <property type="entry name" value="Ovate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006458">
        <property type="entry name" value="Ovate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01568">
        <property type="entry name" value="A_thal_3678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057:SF151">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13724">
        <property type="entry name" value="DNA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04844">
        <property type="entry name" value="Ovate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51754">
        <property type="entry name" value="OVATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OVATE" evidence="8">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="34412" checksum="E41CC5E7E06D7C68" modified="2016-04-13" version="1">MANYRLRISNMIPNSWFYKLKDNKSSSKMTKKESITSSSSSSSLSSAGTLTKTHNDDQVQRKSYYFTRDLNVPNRKKEDSPESPRKSSKKKRPITQKKPLHRNSVPGELNSVVKCHCRVTPESVWTESNPGSNSSDTEFQSPESLNCPCKTISNYDDVYRKLDLPPIITKPAKPEEFGSGKWVIEEGGGSLSVKVKRLPGGKAKGNIYSPRIGNRVRVQAINGGRKSIGNRRGLSASMAVVKTSVNPHKDFKESMVEMIMENNIKSSKDLEDLLACYLSLNSDEYHELIIKVFKQIWFENTNIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6X5</accession>
    <name>A0A103Y6X5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly(ADP-ribose) polymerase, catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6X5"/>
    <dbReference type="Gramene" id="KVI03656">
        <property type="protein sequence ID" value="KVI03656"/>
        <property type="gene ID" value="Ccrd_018036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681:SF103">
        <property type="entry name" value="POLY(ADP-RIBOSE) POLYMERASE, CATALYTIC DOMAIN, ZINC FINGER, C2H2-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20145" checksum="5DA85DDAE1C5095E" modified="2016-04-13" version="1">MKIHNSPKILTRFEEYREIVKSKAARYGGVRRRDERCIADGNELLRFHCATFLCDLGQNGNSSICSHQYCSVCGIIRAGFSSKMDGISTLSTSWKGHVALPEDIEEEFRFMHVKRAMLVCRVIAGRVGCDPEMGDKDDPGYDSLVGRETGGTESKLDDEDELIVFNPRAVLPCFVIAYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y826</accession>
    <name>A0A103Y826_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002289">
        <property type="protein sequence ID" value="KVI04241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y826"/>
    <dbReference type="STRING" id="59895.A0A103Y826"/>
    <dbReference type="Gramene" id="KVI04241">
        <property type="protein sequence ID" value="KVI04241"/>
        <property type="gene ID" value="Ccrd_017439"/>
    </dbReference>
    <dbReference type="OMA" id="LCNQYDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35497">
        <property type="entry name" value="ACYL-UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35497:SF1">
        <property type="entry name" value="ACYL-UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54257" checksum="035B7B1BD01E3DE2" modified="2016-04-13" version="1">MAGRSRELGFLERNGVISLKEQLARTTLRNVRLKGHTYIELREDNKKVIFFCVLCLSPCYSDSVLHDHLRGHLHKQMYEAAKATLLKQNPFPFNDGMLFFHNSSDEDNHLSTANALCGRNLLQKRSINENSLAIVTIEGNVSDYEFSSEESLDSVRGEESLDIDDLIIPDVLYKDKLSDLEVREIGVGKISIRYCERDGVSKGIRKIWCEWLGKSDSVNDDVIPFHDFAVVSFAFDCDLGRKGLLEDLQDILSSSSRPAIVGNNNADGKKRKSPSDPQDFTEPLSNNQYESSGEESLVPGSSNSRSLLDVYDDKSLQLRLVPSKCTRKEIRTRQRLASERVCDICQHKMLPGKNVATLLNMKTGRMVCSSRNLNGYIILQAFHVFHISCLIHWVLLCDSEVYTKQLEGPEVKRRYRRKKGARLEKVVKETRKQIYSAFCPECQGTGIDIDGDELEKPTISLSEENVSPLKLLRFYHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8X7</accession>
    <name>A0A103Y8X7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_016997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01001939">
        <property type="protein sequence ID" value="KVI04684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8X7"/>
    <dbReference type="STRING" id="59895.A0A103Y8X7"/>
    <dbReference type="Gramene" id="KVI04684">
        <property type="protein sequence ID" value="KVI04684"/>
        <property type="gene ID" value="Ccrd_016997"/>
    </dbReference>
    <dbReference type="OMA" id="GICINRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF68">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="33100" checksum="D6049CA12870F04B" modified="2016-04-13" version="1">MVLCLLPVLPPELRANYYIDEDKLVTSNINEIYRYQNNALTNLLTTRRVHETLLGKQINYSGRSVIVVGPSLALHRCRLPRKKSNRTFPGICNLILDDHPVLLNRAPTLHRSGIHDFLPILVERCAICLHPLVCKGFNADFNADQMVVHVPLSAEAQSEAHLLIFSNMKLLSPVIGDPISAPTQDMLSGLFVLNSENCRGICINRYNSCNHRNYQNEDNNYKYTKKEHHFFCNIYDVIGAYWQKQINLGKGKEAEEINLLQKLSEACIVDFSQIDSSTAQKTCDVVNRDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y958</accession>
    <name>A0A103Y958_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeate O-methyltransferase (COMT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001909">
        <property type="protein sequence ID" value="KVI04793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y958"/>
    <dbReference type="Gramene" id="KVI04793">
        <property type="protein sequence ID" value="KVI04793"/>
        <property type="gene ID" value="Ccrd_016884"/>
    </dbReference>
    <dbReference type="OMA" id="HMPAHLK"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000836">
        <property type="entry name" value="O-methyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000294">
        <property type="entry name" value="O-methyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="39694" checksum="34BA766C264D29CE" modified="2016-04-13" version="1">MVTENKEKRISSKEEEAVAQQEIWKYIFGFVPMALVKCSIDLGIPDILENHETPMTLAELASKLNCSQSVLYRIMRFLIHYKIFQEQPLSKTSVGYAQTPLSRLLTRHGENTMVDLVLLETSPIMLAPWHKLSAWVLGNGNSPFEATHGKDLWGFNVENPGHSKLFNDAMACATRVEMAAVIEGCPGVFEGLKTMVDVGGGDGTALRCIVEACPWIKGINYDLPHVVSVAPTSTGVEHVSGNMFDYVPKADAVYLLKVLHDWTDEKCIDILKNCRAAIPQDTGKLIIVDTIIGHKEDDEFKEMGLLLDMVMMAHTSDGKERTLEEWSYLFHEAGFTRYTTKKIQTYLSVFEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y967</accession>
    <name>A0A103Y967_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001905">
        <property type="protein sequence ID" value="KVI04835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y967"/>
    <dbReference type="STRING" id="59895.A0A103Y967"/>
    <dbReference type="Gramene" id="KVI04835">
        <property type="protein sequence ID" value="KVI04835"/>
        <property type="gene ID" value="Ccrd_016818"/>
    </dbReference>
    <dbReference type="OMA" id="WAMNKFD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF211">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="339"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="59120" checksum="745E140067102098" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9N2</accession>
    <name>A0A103Y9N2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9N2"/>
    <dbReference type="Gramene" id="KVI05075">
        <property type="protein sequence ID" value="KVI05075"/>
        <property type="gene ID" value="Ccrd_016565"/>
    </dbReference>
    <dbReference type="OMA" id="LATCPHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000017">
        <property type="entry name" value="3-oxo-5-alpha-steroid 4-dehydrogenase family protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF35">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="158"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="445"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="555" mass="62685" checksum="287597754482F22B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9P7</accession>
    <name>A0A103Y9P7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9P7"/>
    <dbReference type="STRING" id="59895.A0A103Y9P7"/>
    <dbReference type="Gramene" id="KVI05079">
        <property type="protein sequence ID" value="KVI05079"/>
        <property type="gene ID" value="Ccrd_016600"/>
    </dbReference>
    <dbReference type="OMA" id="PPMQMVL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF3">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04949">
        <property type="entry name" value="Transcrip_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="17565" checksum="246315AC5AEE5B05" modified="2016-04-13" version="1">MKNVETKEGGVSIDGNDAEEKRAVALFLAREEEIEKKKMQVREKVKFQLGRAEEETRRLARVWEILTDPMRKEVATVRKKIDTANREVRSLGQSCQKKEKEYREAMEAFHQKNNEKNQLTITLVEVKQLVKESEKGRMKKLEELSKIMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB56</accession>
    <name>A0A103YB56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane receptor, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001860">
        <property type="protein sequence ID" value="KVI05861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB56"/>
    <dbReference type="Gramene" id="KVI05861">
        <property type="protein sequence ID" value="KVI05861"/>
        <property type="gene ID" value="Ccrd_015816"/>
    </dbReference>
    <dbReference type="OMA" id="DIYRRFT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF15">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="237"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="481"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="618" mass="69374" checksum="27F54844D962572D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB95</accession>
    <name>A0A103YB95_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001859">
        <property type="protein sequence ID" value="KVI05919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB95"/>
    <dbReference type="STRING" id="59895.A0A103YB95"/>
    <dbReference type="Gramene" id="KVI05919">
        <property type="protein sequence ID" value="KVI05919"/>
        <property type="gene ID" value="Ccrd_015785"/>
    </dbReference>
    <dbReference type="OMA" id="PAIHDWP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF93">
        <property type="entry name" value="KINASE WITH ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="70"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="38774" checksum="EA6FCDBEABC415C7" modified="2016-04-13" version="1">MEKQKSKAAIEAAEMAKRLAELETQKRRKAELKAEHEEAERKNLMVRLTQCTIQYRKYSIEDIEIATDYFSNSLKIGEGGYGPVFRAYLDHIAVAIKVLRPDISQGQIQFQKEVEVLSCMRHPHMVLLFGACPEYGCLIYEYMENGSLEDRLFRKSNTPPIPWRVRFKICVEIATALHFLHQTRPQPLVHRDLKPGNILLDRNYVSKISDVGLARLVPPEVADDATQYHMTAAAGTFCYIDPEYQQTGLLGTKSDIYSFGVILLQIITAKSPMGLTHLVSRAIKEGNLLNVLDQAVTDWPLDDTQSLAKMALQCCELRKKDRPDLGSVILPELKRLKDLGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBR2</accession>
    <name>A0A103YBR2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001845">
        <property type="protein sequence ID" value="KVI06170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBR2"/>
    <dbReference type="Gramene" id="KVI06170">
        <property type="protein sequence ID" value="KVI06170"/>
        <property type="gene ID" value="Ccrd_015449"/>
    </dbReference>
    <dbReference type="OMA" id="PYITYLN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000657">
        <property type="entry name" value="Putative inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000380">
        <property type="entry name" value="Putative inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF80">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119573" evidence="8">
        <location>
            <begin position="25"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="449"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="735" mass="81494" checksum="29266002F91F5E04" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBV6</accession>
    <name>A0A103YBV6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBV6"/>
    <dbReference type="STRING" id="59895.A0A103YBV6"/>
    <dbReference type="Gramene" id="KVI06254">
        <property type="protein sequence ID" value="KVI06254"/>
        <property type="gene ID" value="Ccrd_015393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050974">
        <property type="entry name" value="Plant_ZF_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506">
        <property type="entry name" value="PROTEIN PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506:SF20">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="576" mass="64113" checksum="94B82C4B6C805200" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBZ2</accession>
    <name>A0A103YBZ2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Quinolinate synthase, chloroplastic</fullName>
            <ecNumber evidence="4">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_015378</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the quinolinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001842">
        <property type="protein sequence ID" value="KVI06279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBZ2"/>
    <dbReference type="STRING" id="59895.A0A103YBZ2"/>
    <dbReference type="Gramene" id="KVI06279">
        <property type="protein sequence ID" value="KVI06279"/>
        <property type="gene ID" value="Ccrd_015378"/>
    </dbReference>
    <dbReference type="OMA" id="MRFWADS"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034628">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10800:FF:000008">
        <property type="entry name" value="Quinolinate synthase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10800:FF:000006">
        <property type="entry name" value="Quinolinate synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000010">
        <property type="entry name" value="Quinolinate synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="entry name" value="NadA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573:SF0">
        <property type="entry name" value="QUINOLINATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="QUINOLINATE SYNTHETASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="NadA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fe-S metabolism associated" evidence="18">
        <location>
            <begin position="88"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI06279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="724" mass="78694" checksum="12BD2221071B1526" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCM0</accession>
    <name>A0A103YCM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001775">
        <property type="protein sequence ID" value="KVI06640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCM0"/>
    <dbReference type="STRING" id="59895.A0A103YCM0"/>
    <dbReference type="Gramene" id="KVI06640">
        <property type="protein sequence ID" value="KVI06640"/>
        <property type="gene ID" value="Ccrd_015009"/>
    </dbReference>
    <dbReference type="OMA" id="WHACASP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF21">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI06640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="110" mass="12349" checksum="68BE88EFFDC12BD1" modified="2016-04-13" version="1">MLIVNRVGARKVMNSELWHACASPLVSLPPIASLVVYFPQGHTSKQPAEFFCKTLTASDTSTHGGFSVPRRAAEKIFPPMDFSMQPLAQELVARDLHDHSWTFRHIYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCT7</accession>
    <name>A0A103YCT7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001710">
        <property type="protein sequence ID" value="KVI06734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCT7"/>
    <dbReference type="STRING" id="59895.A0A103YCT7"/>
    <dbReference type="Gramene" id="KVI06734">
        <property type="protein sequence ID" value="KVI06734"/>
        <property type="gene ID" value="Ccrd_014911"/>
    </dbReference>
    <dbReference type="OMA" id="NAHYSFT"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010444">
        <property type="term" value="P:guard mother cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20543">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000070">
        <property type="entry name" value="CYCLIN D32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000060">
        <property type="entry name" value="D6-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="188"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="339" mass="38674" checksum="FD36A9F8919A7F43" modified="2016-04-13" version="1">MMTLLDSLYCEEKHQWEEDEEEPVDSYSSCVDDEKNIHHQHTNSTELLQEDLFWEEQELTTLISKESQQNFQNNVSDPPSHHRLTAVEWILGVVSHYSFTALTAVLAVNYLDRFLDSFDGFESEKKKPWMTQLAAVSCLSLAAKVEETHVPLLLDLQMEGSKYVFEAKTIQKMEVLILSTLQWKMNPITPLSFLEYITRRLGLRTNLSSEFLKRCECLLLCFLPDGRFRRYLPSVIATATMVHVINSVEPCIGIDYQSQLVGILGINKEKVNECWEEMQEMLSCSKNGGRHFNKRKFGAVPGSPNAVMDLCFSSDESWSSEVSSSPETGHKKSRKDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEC1</accession>
    <name>A0A103YEC1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_014076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEC1"/>
    <dbReference type="STRING" id="59895.A0A103YEC1"/>
    <dbReference type="Gramene" id="KVI07542">
        <property type="protein sequence ID" value="KVI07542"/>
        <property type="gene ID" value="Ccrd_014076"/>
    </dbReference>
    <dbReference type="OMA" id="PHFLLEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016004">
        <property type="term" value="F:phospholipase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="224" mass="25641" checksum="FA3B6A9856D35151" modified="2016-04-13" version="1">MFFLRQKGRFSEATTRPPALFYYNSDSGFFFRSTKLTGPFPSTGQKGFNVEKVQYKNVMFTVWDVGGQEKLRPLWRHYFNDTNGLVRITTTSVVFNIVPNNEISYPHFLLEYNSLVFKISAILKIYVVDSLDRERISKAKAEFQAIINDPFMTNCVILVFANKQDMKGAMTPMEVCEGLGLYELKNRKWHIQGTCALRGDGLYEGLDWLASTLKDMKAASTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YES9</accession>
    <name>A0A103YES9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_013865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001488">
        <property type="protein sequence ID" value="KVI07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YES9"/>
    <dbReference type="STRING" id="59895.A0A103YES9"/>
    <dbReference type="Gramene" id="KVI07778">
        <property type="protein sequence ID" value="KVI07778"/>
        <property type="gene ID" value="Ccrd_013865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="8">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="111" mass="12515" checksum="DF770FA7A9A0341F" modified="2016-04-13" version="1">MEELSLFLQIRFLFTNLRIIRSHGDDLAPDCWNWWSRNYSYTEISNHTLLLGIVVAATGAGGVVAYIGLEGNSHSRWNKICHTYGSFCFHFAASILPVLGGRRLVMALEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEW2</accession>
    <name>A0A103YEW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001484">
        <property type="protein sequence ID" value="KVI07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEW2"/>
    <dbReference type="Gramene" id="KVI07820">
        <property type="protein sequence ID" value="KVI07820"/>
        <property type="gene ID" value="Ccrd_013819"/>
    </dbReference>
    <dbReference type="OMA" id="CERVYNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15796">
        <property type="entry name" value="CIF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034087">
        <property type="entry name" value="C/VIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052421">
        <property type="entry name" value="PCW_Enzyme_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36710:SF18">
        <property type="entry name" value="PECTINESTERASE INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36710">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119658" evidence="4">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="19742" checksum="2E31EC2A3AFFD9D4" modified="2016-04-13" version="1">MAMKLWSPFTIVFLVLIFQESLLFSAMADRKFIESVCRSTPSTNLCLKTVLADPKSKDADLTGLALIIVYAVKDKGNKIIHQIKTLEKHGRPELRPVLKYCERVYNTAVTVDVKLAVDALTLGNVKFGENGMADVVVESRSCEDTFDQYALKSPMTEINKGMEDIANVARAIIRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEW7</accession>
    <name>A0A103YEW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001483">
        <property type="protein sequence ID" value="KVI07827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEW7"/>
    <dbReference type="STRING" id="59895.A0A103YEW7"/>
    <dbReference type="Gramene" id="KVI07827">
        <property type="protein sequence ID" value="KVI07827"/>
        <property type="gene ID" value="Ccrd_013794"/>
    </dbReference>
    <dbReference type="OMA" id="KSYWTEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025771">
        <property type="entry name" value="Phosphoethanolamine_N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51582">
        <property type="entry name" value="SAM_PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="312"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="522" mass="59774" checksum="CEA1308ED3326F8D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF58</accession>
    <name>A0A103YF58_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001454">
        <property type="protein sequence ID" value="KVI07959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF58"/>
    <dbReference type="STRING" id="59895.A0A103YF58"/>
    <dbReference type="Gramene" id="KVI07959">
        <property type="protein sequence ID" value="KVI07959"/>
        <property type="gene ID" value="Ccrd_013681"/>
    </dbReference>
    <dbReference type="OMA" id="SFFARDK"/>
    <dbReference type="OrthoDB" id="745501at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000679">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g03800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002102">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF512">
        <property type="entry name" value="REPEAT (PPR) SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="777"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="868" mass="97942" checksum="89C248844181653A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFC9</accession>
    <name>A0A103YFC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001371">
        <property type="protein sequence ID" value="KVI08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFC9"/>
    <dbReference type="Gramene" id="KVI08062">
        <property type="protein sequence ID" value="KVI08062"/>
        <property type="gene ID" value="Ccrd_013572"/>
    </dbReference>
    <dbReference type="OMA" id="NLEERKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="73" mass="8860" checksum="52A51E569076628D" modified="2016-04-13" version="1">MSHDPQESVLEDEGEEEEEEEEGEEEEEEEEEEEGEEEEEEEEEEEEEEEEEEEEEEEEEEETNSEDESNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFP2</accession>
    <name>A0A103YFP2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_013404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001184">
        <property type="protein sequence ID" value="KVI08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFP2"/>
    <dbReference type="STRING" id="59895.A0A103YFP2"/>
    <dbReference type="Gramene" id="KVI08226">
        <property type="protein sequence ID" value="KVI08226"/>
        <property type="gene ID" value="Ccrd_013404"/>
    </dbReference>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="416"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="521" mass="56161" checksum="11AEF5E163BA4BFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFV3</accession>
    <name>A0A103YFV3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_013296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001138">
        <property type="protein sequence ID" value="KVI08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFV3"/>
    <dbReference type="STRING" id="59895.A0A103YFV3"/>
    <dbReference type="Gramene" id="KVI08337">
        <property type="protein sequence ID" value="KVI08337"/>
        <property type="gene ID" value="Ccrd_013296"/>
    </dbReference>
    <dbReference type="OMA" id="DPNTRNC"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000034">
        <property type="entry name" value="Aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051708">
        <property type="entry name" value="Plant_Aspart_Prot_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967">
        <property type="entry name" value="OS07G0603500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967:SF36">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119678" evidence="7">
        <location>
            <begin position="22"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="85"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="49606" checksum="1FF1227E58527A1D" modified="2016-04-13" version="1">MASSSLYLLFILSLLSSHSSSSQTTLTLSPTPISIAPSPQSNHHHPWLQTLNYLASSSLARAHHLKHPKDNSSQIPLFPQSYGGYSVSLSFGSPPQKLSFVMDTGSSLVWFPCTHRYQCSDCQFSNVNPNNISRFIPKLSSSSKIIGCSNKKCGWVFGSSNPIQCNGKEICPAYMLQYGSGSTAGLMLSETLDFPEGDVTDFAVGCSILSTRQPSGIAGFGRGPASLPVQMGLKRFSYCLVSHRFDDAPVSSELVLVRDSSNSGGSDAGISYTKFHKNPVSSRSSFQDYYYVNLRKITVGGKTVKIPYGFLVPGSDGNGGTIIDSGTTFTFMDNHVYDLVAKEFENQMSKYKRSGEMESKSGLRPCFDIGDKPVKIPALMFHFKGGAKLSLPLADYFSFMGESDVVCMTIVSSESIGSDTRIGPSIILGNYQQQNIYLEYDLEKGRLGFKNQICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH33</accession>
    <name>A0A103YH33_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="9">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_012641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01001076">
        <property type="protein sequence ID" value="KVI08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH33"/>
    <dbReference type="STRING" id="59895.A0A103YH33"/>
    <dbReference type="Gramene" id="KVI08981">
        <property type="protein sequence ID" value="KVI08981"/>
        <property type="gene ID" value="Ccrd_012641"/>
    </dbReference>
    <dbReference type="OMA" id="FLEWNRG"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000001">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119716" description="6-phosphogluconate dehydrogenase, decarboxylating" evidence="10">
        <location>
            <begin position="27"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="224"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="526" mass="58452" checksum="132A33863C070606" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHN3</accession>
    <name>A0A103YHN3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein 60S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_012339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="Ccrd_012339"/>
    </dbReference>
    <dbReference type="OMA" id="THIVFPY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="11433" checksum="517F20EC5AB4B319" modified="2016-04-13" version="1">MKVVAAYLLALLGGNTSPSANDLKNILGSVGADCDEDRIELLLSEVKGKDITELIASGREKLASVPSGGGGVAVAAAAGGGAAPAAAAAAEPKKEEKVEEKEESDDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI37</accession>
    <name>A0A103YI37_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001058">
        <property type="protein sequence ID" value="KVI09507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI37"/>
    <dbReference type="STRING" id="59895.A0A103YI37"/>
    <dbReference type="Gramene" id="KVI09507">
        <property type="protein sequence ID" value="KVI09507"/>
        <property type="gene ID" value="Ccrd_012114"/>
    </dbReference>
    <dbReference type="OMA" id="ADLYWAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="4">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="982" mass="109428" checksum="340E2EE8DEB5E219" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIX4</accession>
    <name>A0A103YIX4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001036">
        <property type="protein sequence ID" value="KVI09927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIX4"/>
    <dbReference type="STRING" id="59895.A0A103YIX4"/>
    <dbReference type="Gramene" id="KVI09927">
        <property type="protein sequence ID" value="KVI09927"/>
        <property type="gene ID" value="Ccrd_011676"/>
    </dbReference>
    <dbReference type="OMA" id="VWDRHLM"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050898">
        <property type="entry name" value="Plant_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147:SF1">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="443" mass="49189" checksum="E3DD55345B1F5730" modified="2016-04-13" version="1">MTNMESSAAQVHVKEAALVVPSDPTPTHLLKLSSVDSQLFLRFTIEYLLIYRFNGLHTDHVTARVKSALARALVPYYPLAGRVRVRPDGSCLEVVCRAQGAVFIEATADFTLSDFERAPRYVTEWRRLLALQVADVLKGAPPLVVQLTWLSDGAAALGVGYSHCICDGVGSVEFLNLFAALATGRRHGGGLEFKPKPIWQRHLLDQTPFKQPRPRQHLEFSRVTDHCQFMTRFTPDQLTPTAVTFDEWRLNELKNSITPTSQLSKSSLTSFEVLSAKVWRSWAKALNFPPQQILKLLFSIDIRHRVKPSLPTGYYGNAIVLGCAQATARDLTEKGLAYATELIKEAKNRVDDQYVKEVVNSVSLNGARGVPDPVGVLILSQWSKLGLERVDFGIGRPVQVGPVCTDKYCILLPVDDHSRSVKVMLAVPSVAVDKYVDLMRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJF9</accession>
    <name>A0A103YJF9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folylpolyglutamate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJF9"/>
    <dbReference type="STRING" id="59895.A0A103YJF9"/>
    <dbReference type="Gramene" id="KVI10194">
        <property type="protein sequence ID" value="KVI10194"/>
        <property type="gene ID" value="Ccrd_011412"/>
    </dbReference>
    <dbReference type="OMA" id="NLGWRIS"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000012">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="103"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Mur ligase C-terminal" evidence="7">
        <location>
            <begin position="391"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="556" mass="59964" checksum="0BB9929B9922CA93" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK56</accession>
    <name>A0A103YK56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunoglobulin E-set</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001007">
        <property type="protein sequence ID" value="KVI10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK56"/>
    <dbReference type="STRING" id="59895.A0A103YK56"/>
    <dbReference type="Gramene" id="KVI10639">
        <property type="protein sequence ID" value="KVI10639"/>
        <property type="gene ID" value="Ccrd_010960"/>
    </dbReference>
    <dbReference type="OMA" id="HICQDWE"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000002">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="26831" checksum="925AC8CA7582CF31" modified="2016-04-13" version="1">MSLAVEAVSSSTNMGLEENKEGEKSGFEENGDEKQSMKRVGSESSFYETEDEEEDKQIELGPQCTLKEQFEKDKDDESLRKWKEQLLGNVDINDVGESLEPEVKILILSILSPGRSEIVLPIPEDGKPKGPWFTLKEGCRYSLRFSFQVGHNIVAGLKYTNYVWKTGVKVDSTKQMLGTFSPQQEAYTYDMPEETTPSGYFARGSYSAKTKFVDDDNKCYLEINYTFDIRKDWASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLQ7</accession>
    <name>A0A103YLQ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Remorin, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the remorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000326">
        <property type="protein sequence ID" value="KVI11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLQ7"/>
    <dbReference type="STRING" id="59895.A0A103YLQ7"/>
    <dbReference type="Gramene" id="KVI11347">
        <property type="protein sequence ID" value="KVI11347"/>
        <property type="gene ID" value="Ccrd_010244"/>
    </dbReference>
    <dbReference type="OMA" id="VAGSAME"/>
    <dbReference type="OrthoDB" id="1939615at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005516">
        <property type="entry name" value="Remorin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471">
        <property type="entry name" value="OS02G0116800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471:SF101">
        <property type="entry name" value="REMORIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03763">
        <property type="entry name" value="Remorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Remorin C-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="31571" checksum="B807BA94806C27BD" modified="2016-04-13" version="1">MSNDQRPPSSSTHPHHDDDDDDDDDDDENIREIHALTSPLPPPPPAYPHRHWETTSHHRSSSLSVASTEGESFTTMSREFNALVLAGTGIHVNGSENSEVANSTNTNNESSSNLERIGEEEMTETNPLAIVPDHNPLAIVPDHNPLEASPSGTRSMITTGGNPGEVSVQTVKKEEVESKISAWQNAKISKINNRFKRDDAIINGWENEQVQKSSSWMKIVERKLEAKRARAMEKMQNEIAKARRKAEERRATAEAKRGTKVARVLEVANLMRVVGRAPAKRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLX1</accession>
    <name>A0A103YLX1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_010149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000123">
        <property type="protein sequence ID" value="KVI11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YLX1"/>
    <dbReference type="Gramene" id="KVI11437">
        <property type="protein sequence ID" value="KVI11437"/>
        <property type="gene ID" value="Ccrd_010149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Cupin type-1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="18896" checksum="D07D5136A6FE2E7E" modified="2016-04-13" version="1">MMNNVGANLIRSNCSGTGDRDGATVATGDGTMVRRRRAETGAATSGDRGGDERRGGRWCVGIKQQEGYGGVWALSSERKAVVWRGEGEDLGDEEFSCFSFLGLQKGDVFVFPQGLIHFQRNVGNGHAXAIAALSSQNPGAITIANAVFGSNPDIARDILAKAFQVDKNVVYQIQSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLX8</accession>
    <name>A0A103YLX8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000086">
        <property type="protein sequence ID" value="KVI11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLX8"/>
    <dbReference type="STRING" id="59895.A0A103YLX8"/>
    <dbReference type="Gramene" id="KVI11539">
        <property type="protein sequence ID" value="KVI11539"/>
        <property type="gene ID" value="Ccrd_010049"/>
    </dbReference>
    <dbReference type="OMA" id="YPRETNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25348" checksum="AC7605111443B52A" modified="2016-04-13" version="1">MDPESKKFGKGPRELTGAVDLISYYKLLPHHEFFCKKSLPLSISDTHYLHNVPGDSEIRKGEGMQLDQLIQNTSFPRETNSRIQPFDLDILREAFQLRETAPVDLPSSEKGIPTIAGKSKSEAKDKERKHKKHKDKDRDKDKEHKKHKHRHKDRSKEKDKEKKKDKSSHHDSGAEPSKKHHEKKRKHDGDEDLNDIHRHKKSKHKSSKIDEMGAIKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMJ7</accession>
    <name>A0A103YMJ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01000025">
        <property type="protein sequence ID" value="KVI11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMJ7"/>
    <dbReference type="STRING" id="59895.A0A103YMJ7"/>
    <dbReference type="Gramene" id="KVI11930">
        <property type="protein sequence ID" value="KVI11930"/>
        <property type="gene ID" value="Ccrd_009700"/>
    </dbReference>
    <dbReference type="OMA" id="PSWRGDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119861" description="cellulase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="29"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="44231" checksum="076912227EA7227A" modified="2016-04-13" version="1" fragment="single">MAESCSSMILLALFAGFWVCVNAHEKLNYQEALTKSIIFLEAQRSGKLPPTNRVPWRGDSALEDGKLVGVDLVGGYYDAGDNVKFGLPMAFTVTTMAWGAYFYHFELEATGEMNNLLDAIRWGTDYLLKASSQRNRLFVENMKTPRTVLEINDKTPGTEIAGETAAALAASSLAFRKSDQPYADKLLETAIQVFQFADEYRGTFDGACPFYCSYSGFNYMKYILEQSTTATVFEFSWDLKYAGAQVLLSQENNSHVNAIAGGYLNLRDGANSQYVTSTALLFSIYSDLLARHNMQVTCGHNPVKRSMMVGFGNNPPVQAHHRGASVPANAVKEDINCGMSFVYWYNVDTPNPNELTGAILGGPDRQDQFVDKRVNSSYTEPCTYVNACAIGVLAKLAKHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN19</accession>
    <name>A0A103YN19_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fructose-bisphosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_009470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN19"/>
    <dbReference type="STRING" id="59895.A0A103YN19"/>
    <dbReference type="Gramene" id="KVI12114">
        <property type="protein sequence ID" value="KVI12114"/>
        <property type="gene ID" value="Ccrd_009470"/>
    </dbReference>
    <dbReference type="OMA" id="RCMAVGT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010319">
        <property type="term" value="C:stromule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000014">
        <property type="entry name" value="Fructose-1,6-bisphosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="73"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="279"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="387" mass="41961" checksum="900088E3984184B9" modified="2016-04-13" version="1">MAATTSSNLLHFSSSHSVSRLTPLKTTTTLFSCSKKRPFTSAPAGGAATAGVRCMAVVSEAGSVKKTSSYQIMTLTNWLLQQEQSGAIDAELTIVLSSISMACKQIASLVQRASISNLTGVQGAVNIQGEDQKKLDVVSNEVFSNCLRSSGRTGIIASEEEDVPVAVEESYSGNYIVVFDPLDGSSNIDAAVSTGSIFGIYSPNDECLAPEIGDDSTLGTEEQRCVVSVCQPGNNLLAAGYCMYSSSVIFVLSIGKGVYAFTLDPMYGEFVLTQEKIQIPRSGKIYSFNEGNYQLWDDKLKKYMDDLKDPGPTGKPYSARYIGSLVGDFHRTLLYGGIYGYPRDKKSKNGKLRLLYECAPMSYLIHQRVPLFIGSVEEVEKLEKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118GB76</accession>
    <name>A0A118GB76_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008961">
        <property type="protein sequence ID" value="KVF84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118GB76"/>
    <dbReference type="Gramene" id="KVF84910">
        <property type="protein sequence ID" value="KVF84910"/>
        <property type="gene ID" value="Ccrd_026645"/>
    </dbReference>
    <dbReference type="OMA" id="RRYLEAX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVF84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="319" mass="36301" checksum="557881A5F174DD2E" modified="2016-04-13" version="1">MDRVAEVGLNKVGEFNSQNVANIAGAFASMQHAAPDLFSEISKRASNIIHTFQSQELAQPLWAFASLVEPADSIFASLDDVYKDAHQYRCSLDKRTLKFTEPRGAESIKVEGFPPVLDFNRDQLGNISWSCAVLGQMDRTFFSHVWKTLGYFEEQQISEQYREDIMFATQIQLVNQCLKLEYPHSLLSLKSDIEDKIIRAGKTARFNQKITSSFQKEVDHLLVSTGLYWTREYVVDGYTLDAALIDLKVALEIDGPTHFSRNSGNPLGHTVLKRRYLEAXGWKLVSVSHQKWEELEGSHEQLDYLREILQDHTADEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRG4</accession>
    <name>A0A118JRG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_025238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006130">
        <property type="protein sequence ID" value="KVH87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRG4"/>
    <dbReference type="STRING" id="59895.A0A118JRG4"/>
    <dbReference type="Gramene" id="KVH87502">
        <property type="protein sequence ID" value="KVH87502"/>
        <property type="gene ID" value="Ccrd_025238"/>
    </dbReference>
    <dbReference type="OMA" id="ITDAYEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="97" mass="11306" checksum="7CCC19441F2C3CA1" modified="2016-04-13" version="1">MRLNRSDLNLLYSTRYSKEITDAYEWLLLDAIRGERRLFIRSDELDAAWSIFTPLLKELEAKKIAPELYLYGSRGFVGAHYLAANYNVRWGDLASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSQ5</accession>
    <name>A0A118JSQ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">F-ATPase gamma subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_008382</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005195">
        <property type="protein sequence ID" value="KVH89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSQ5"/>
    <dbReference type="STRING" id="59895.A0A118JSQ5"/>
    <dbReference type="Gramene" id="KVH89617">
        <property type="protein sequence ID" value="KVH89617"/>
        <property type="gene ID" value="Ccrd_008382"/>
    </dbReference>
    <dbReference type="OMA" id="VMQFEQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000003">
        <property type="entry name" value="ATP synthase gamma chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000004">
        <property type="entry name" value="ATP synthase gamma chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000004">
        <property type="entry name" value="ATP synthase gamma chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004145">
        <property type="entry name" value="PRK05621.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF41">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="40480" checksum="FEF30AC7212F3796" modified="2016-04-13" version="1">MWVSSKPSTLDSSSLSFRSSFINPLQIPSSNPSNSSKSSSSSVHCSLRELRNRIDSVTNTKKITEAMKLVAAAKVRRAQEAVVNARPFSETLVEVLYSINEQLQTEDVDVPLTSVRPVKKVALVVITGDRGLCGGFNNAILKKAEARIRELKTLGLEFTVISVGKKGNTYFLRRPYIPLDKYLDGSNLPTAKEAQAIADDVFSLFVSEEVDKVELLYTKFVSLVKSDPVIHTLLPLSPKGEICDINGICVDAAEDEFFRLTTKEGKLTVERDVVRTETMDFSPILQFEQDPVQILDALLPLYLNSQILRALQESLASELAARMTAMGNATDNAVELKKNLSRVYNRQRQAKITGEILEIVAGADALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT62</accession>
    <name>A0A118JT62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_008784</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005287">
        <property type="protein sequence ID" value="KVH89232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT62"/>
    <dbReference type="STRING" id="59895.A0A118JT62"/>
    <dbReference type="Gramene" id="KVH89232">
        <property type="protein sequence ID" value="KVH89232"/>
        <property type="gene ID" value="Ccrd_008784"/>
    </dbReference>
    <dbReference type="OMA" id="LSEYTHD"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000005">
        <property type="entry name" value="subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159642" evidence="11">
        <location>
            <begin position="23"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="14">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="129"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="15">
        <location>
            <begin position="656"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH89232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="765" mass="81122" checksum="8DA7F20805F11D42" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT71</accession>
    <name>A0A118JT71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_008242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005143">
        <property type="protein sequence ID" value="KVH89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT71"/>
    <dbReference type="STRING" id="59895.A0A118JT71"/>
    <dbReference type="Gramene" id="KVH89771">
        <property type="protein sequence ID" value="KVH89771"/>
        <property type="gene ID" value="Ccrd_008242"/>
    </dbReference>
    <dbReference type="OMA" id="IVMSKQN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000004">
        <property type="entry name" value="50S ribosomal protein L19, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19CY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="248" mass="27553" checksum="1EC4F84BB30DCF4B" modified="2016-04-13" version="1">MPSGNSDKTLQALALSSSQNSVMANIVLPQALFMIPTNVAKFQSKKLGVSAFLPPFNAASASIFSVSSSRCRFNLGFGNRDSFVVRAEADAAADAEPETTSVVTEVTDDVEDETVKEDEEEVEAKPPRKPIVKLGDIMGILNKQAIEASESSRPVPDLRTGDIIEIKFEVPENRRRLSIYKGIIISRQNAGIHTTIRIRRIIAGVGVEIVFPRYSPNIKEIKVVKHRKVRRARLYYLRDKLPRLSTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT80</accession>
    <name>A0A118JT80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="23">5'-3' exonuclease, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_008582</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT80"/>
    <dbReference type="STRING" id="59895.A0A118JT80"/>
    <dbReference type="Gramene" id="KVH89439">
        <property type="protein sequence ID" value="KVH89439"/>
        <property type="gene ID" value="Ccrd_008582"/>
    </dbReference>
    <dbReference type="OMA" id="CCVAVDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10 23" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="22">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="21">
        <location>
            <begin position="182"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVH89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="738" mass="83387" checksum="8C5DE4E092C98329" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUF1</accession>
    <name>A0A118JUF1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004980">
        <property type="protein sequence ID" value="KVH91451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUF1"/>
    <dbReference type="STRING" id="59895.A0A118JUF1"/>
    <dbReference type="Gramene" id="KVH91451">
        <property type="protein sequence ID" value="KVH91451"/>
        <property type="gene ID" value="Ccrd_006527"/>
    </dbReference>
    <dbReference type="OMA" id="HNGPMDV"/>
    <dbReference type="OrthoDB" id="1609931at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36759">
        <property type="entry name" value="DYNEIN BETA CHAIN, CILIARY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36759:SF1">
        <property type="entry name" value="DYNEIN BETA CHAIN, CILIARY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="188" mass="21099" checksum="DD8BBFF84E151424" modified="2016-04-13" version="1">MGQAFRRASGRIRTSQPPSSPSQLNKPLDRTQPLPPLDDKLPHGRNVDPSSEGQPRNNADNVIEERDSQYDAMLSKMVGRIQTKPGGKLEMGEAFVVDKYNRPMPKLRNTTPETGRYEQIPAPPGTLNIAQLRQIILLYHGKSNDHKGPMDVNQIAEKFRVDVAQVQRTVQFLSLPPESANKQKNDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUZ2</accession>
    <name>A0A118JUZ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_005472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004816">
        <property type="protein sequence ID" value="KVH92487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUZ2"/>
    <dbReference type="STRING" id="59895.A0A118JUZ2"/>
    <dbReference type="Gramene" id="KVH92487">
        <property type="protein sequence ID" value="KVH92487"/>
        <property type="gene ID" value="Ccrd_005472"/>
    </dbReference>
    <dbReference type="OMA" id="HLHLMET"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016463">
        <property type="term" value="F:P-type zinc transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009642">
        <property type="term" value="P:response to light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02079">
        <property type="entry name" value="P-type_ATPase_HM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051949">
        <property type="entry name" value="Cation_Transport_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43079:SF1">
        <property type="entry name" value="CADMIUM_ZINC-TRANSPORTING ATPASE HMA1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43079">
        <property type="entry name" value="PROBABLE CADMIUM/ZINC-TRANSPORTING ATPASE HMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="192"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH92487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="780" mass="84312" checksum="573F18B00A01D7A9" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVZ5</accession>
    <name>A0A118JVZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004602">
        <property type="protein sequence ID" value="KVH93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVZ5"/>
    <dbReference type="STRING" id="59895.A0A118JVZ5"/>
    <dbReference type="Gramene" id="KVH93787">
        <property type="protein sequence ID" value="KVH93787"/>
        <property type="gene ID" value="Ccrd_004157"/>
    </dbReference>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="39789" checksum="92A4840A4A3EE395" modified="2016-04-13" version="1">MDGNKDDALRCLKIGKDALGLGDRARALKFISKAHRLDPSLPVDDLLSKLEGDNTGNESPSASSSSKPSETGAGDSSGIRHRVPATGSSSGSGVYTEEQVTIVREIRRKKDYYEILGLEKACSVEDVRKSYRKLSLRVHPDKNKAPGSEEAFKKVSKAFQCLSVDENRKQYDLVGSDEPVYERRTASRGAHHHGFSNGFYYDGDVDADEIFRNFFFGGMNPAATTQFTGFRFGPGMGAPAGNGSAGIRTLIQLLPVLLILLLNFLPSNEPIYSLSRSYGYEHRLSTQKGIVFFVKSANFEQDYPLNSPERSQLEEKIEHEYVSILSHNCRLEMQRIHWGYQQETPNCDMLKQFKALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWA5</accession>
    <name>A0A118JWA5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_002693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWA5"/>
    <dbReference type="Gramene" id="KVH95259">
        <property type="protein sequence ID" value="KVH95259"/>
        <property type="gene ID" value="Ccrd_002693"/>
    </dbReference>
    <dbReference type="OMA" id="KARIRLC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="348" mass="39526" checksum="D90A0932CCF3C087" modified="2016-04-13" version="1">MKCFSIFHSKSTHPRDQKSKSAAKAVKSTGSISSPRSIPELYKEKEHNLKKFSFSELRNATTNFNKLLKIGEGGFGSVYKARIRLSESQNDPLVVAIKRLNKQGMQGHKEWLTEIQFLGVVDHPNLVKLLGYCSVDGERVMQRLLVYEYMPNKSLAVHLFSTTLPPIPWKTRLRILLGAAEGLAYLHEGLEIQVIYRDFKSSNVLLDEKFNAKLSDLGLAREEYIETGHLKSKSDVWSFGVVLFEVLTGRPTVDRKLPKAEQKLIEWVKQFPPNSRKFWMVMDRRLNNQYSLDAARSIAKLAVSCLYKNPNDRPTMSQIVKGLKNTIKESESGLIVPEKRSPVSKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWR5</accession>
    <name>A0A118JWR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_002926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01004458">
        <property type="protein sequence ID" value="KVH95002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWR5"/>
    <dbReference type="STRING" id="59895.A0A118JWR5"/>
    <dbReference type="Gramene" id="KVH95002">
        <property type="protein sequence ID" value="KVH95002"/>
        <property type="gene ID" value="Ccrd_002926"/>
    </dbReference>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010037">
        <property type="term" value="P:response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010118">
        <property type="term" value="P:stomatal movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000002">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000125">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF7">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="22"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="102"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH95002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="557" mass="60563" checksum="D766264ED73A13C7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX40</accession>
    <name>A0A118JX40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004485">
        <property type="protein sequence ID" value="KVH94960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX40"/>
    <dbReference type="STRING" id="59895.A0A118JX40"/>
    <dbReference type="Gramene" id="KVH94960">
        <property type="protein sequence ID" value="KVH94960"/>
        <property type="gene ID" value="Ccrd_002971"/>
    </dbReference>
    <dbReference type="OMA" id="MAHNQFT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31016:SF20">
        <property type="entry name" value="HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31016">
        <property type="entry name" value="OS04G0228100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="412" mass="46140" checksum="B8EF7E6D2C1F6755" modified="2016-04-13" version="1">MAYRRRQGISRASTFKEDTIHRSPNDDDTTTSSSAAPSSSLAAQAIRASAAHRDSSISSAYPNSAFHSSFKDGSKGSATYDYTSMGSTNEPGGFWGVLARKAKAILDDDDDVPRHFDSPSSVKPEAVSTSNQVQHQYESFENSRKMDNPTLRKGLDRFTSSLNQIGDTIGNALEEGRTIVDKKTHDIIQETRKLQNRRRGTNDEHNQVSGIQSQSQEPRMQSTQQQTNQENQIKASRDVRWQMCNCIFVVEATQYVSFPMKCIVAFCFGLQVAIATAAKAKLLLRELKTLKADLAFAKQRSSQLEEENKMLREALEKGDNPADDDMIRLQLESLLAEKARLANENSVYARENRFLREIVEYHQLTMQDVVYLDDGIEEVTEVHRGVSRMLSMSPPLPSSPRAPLKRTISEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYM6</accession>
    <name>A0A118JYM6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYM6"/>
    <dbReference type="STRING" id="59895.A0A118JYM6"/>
    <dbReference type="Gramene" id="KVH98007">
        <property type="protein sequence ID" value="KVH98007"/>
        <property type="gene ID" value="Ccrd_023764"/>
    </dbReference>
    <dbReference type="OMA" id="WRHIMAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34953">
        <property type="entry name" value="ALPHA/BETA HYDROLASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34953:SF1">
        <property type="entry name" value="ALPHA_BETA HYDROLASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="388"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="567" mass="62361" checksum="B1D0621BCD315ACC" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZC5</accession>
    <name>A0A118JZC5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003421">
        <property type="protein sequence ID" value="KVH99686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZC5"/>
    <dbReference type="Gramene" id="KVH99686">
        <property type="protein sequence ID" value="KVH99686"/>
        <property type="gene ID" value="Ccrd_022077"/>
    </dbReference>
    <dbReference type="OMA" id="SKGFAWD"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14327">
        <property type="entry name" value="UBA_atUPL1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000067">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF398">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3326"/>
            <end position="3676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1688"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2012"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2074"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2126"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2264"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2390"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2473"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2564"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2682"/>
            <end position="2720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2969"/>
            <end position="3003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1688"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1706"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2075"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2127"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2167"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2289"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2396"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2514"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2570"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2683"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2704"/>
            <end position="2713"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH99686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="3676" mass="405163" checksum="1517796DA7D63353" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K067</accession>
    <name>A0A118K067_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">1,3-beta-glucan synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_021124</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003365">
        <property type="protein sequence ID" value="KVI00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K067"/>
    <dbReference type="Gramene" id="KVI00628">
        <property type="protein sequence ID" value="KVI00628"/>
        <property type="gene ID" value="Ccrd_021124"/>
    </dbReference>
    <dbReference type="OMA" id="HISVYKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058851">
        <property type="entry name" value="CALS1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF80">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25968">
        <property type="entry name" value="CALS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1471"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1514"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1636"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1717"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1742"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1779"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1806"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1846"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="15">
        <location>
            <begin position="257"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1904" mass="218483" checksum="E076ABE0D6081AF7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K158</accession>
    <name>A0A118K158_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002662">
        <property type="protein sequence ID" value="KVI02130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K158"/>
    <dbReference type="Gramene" id="KVI02130">
        <property type="protein sequence ID" value="KVI02130"/>
        <property type="gene ID" value="Ccrd_019586"/>
    </dbReference>
    <dbReference type="OMA" id="QGFVPKM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="43367" checksum="92559C89D6EC790A" modified="2016-04-13" version="1">MITRSIIASTAKLRKIYQLNWYHSAASIDSSTKPHPFNLLDHKDWLSPNEVVKIFETLKDPNSTLTVLNQLSKRKDYKPNEALYASVIDNLSKAKNFDGIEQVMKLIKLEKGCRLSDGFFYNVIRIYGLGAGRINRAIDTLFDMPSYGCWPTPKTFNFVLNLLVNTKQFDVIHEVFMAAGKLGVEIDACCLNIMIKGLCKNGDVNAALQVFDEFPKQNCKPNVRTFSALIHGLCESGRIEEAFSFLEKMETEGVDPDTILINILISGLRKNGRIQESIELFNRMLLKGCEPIPSSYQEVLYALLDSRKYAEAINLTQKMSSKKMVPSFESYKLMISGLCEENLMSDVNLVLKQMIENGFVPKMAMWRQILQCMLSGKTTSYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K163</accession>
    <name>A0A118K163_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WEB family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WEB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K163"/>
    <dbReference type="STRING" id="59895.A0A118K163"/>
    <dbReference type="Gramene" id="KVI02343">
        <property type="protein sequence ID" value="KVI02343"/>
        <property type="gene ID" value="Ccrd_019371"/>
    </dbReference>
    <dbReference type="OMA" id="RQFEEYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009904">
        <property type="term" value="P:chloroplast accumulation movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009903">
        <property type="term" value="P:chloroplast avoidance movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008545">
        <property type="entry name" value="Web"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054">
        <property type="entry name" value="HEAVY CHAIN, PUTATIVE, EXPRESSED-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054:SF93">
        <property type="entry name" value="WEB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05701">
        <property type="entry name" value="WEMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="257"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="493"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70109" checksum="D89F40EADC8FEC2B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2I4</accession>
    <name>A0A118K2I4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA-type, CDC48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002054">
        <property type="protein sequence ID" value="KVI04442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2I4"/>
    <dbReference type="STRING" id="59895.A0A118K2I4"/>
    <dbReference type="Gramene" id="KVI04442">
        <property type="protein sequence ID" value="KVI04442"/>
        <property type="gene ID" value="Ccrd_017241"/>
    </dbReference>
    <dbReference type="OMA" id="EIATICQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF180">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 HOMOLOG D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="9906" checksum="874D124FC8BB432E" modified="2016-04-13" version="1">MDGMSAKKTVFIIDATNKPDIIDPALLRPGRLDQLIYIPLPDEESRYQIFKSALRKSPVSKDVNLRALAKYIQAFQSLYNTAFTWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K308</accession>
    <name>A0A118K308_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">Ccrd_016513</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">May be involved in plant defense signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI05177">
        <property type="protein sequence ID" value="KVI05177"/>
        <property type="gene ID" value="Ccrd_016513"/>
    </dbReference>
    <dbReference type="OMA" id="VFGKERC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000244">
        <property type="entry name" value="Serine/threonine-protein kinase CDL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985">
        <property type="entry name" value="OS07G0668900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985:SF46">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="75"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="444"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="876"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1302"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="819"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00054261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KVI05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1632" mass="181690" checksum="FD968311726B190E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K638</accession>
    <name>A0A118K638_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K638"/>
    <dbReference type="STRING" id="59895.A0A118K638"/>
    <dbReference type="Gramene" id="KVI10110">
        <property type="protein sequence ID" value="KVI10110"/>
        <property type="gene ID" value="Ccrd_011456"/>
    </dbReference>
    <dbReference type="OMA" id="CEICRCH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46398:SF4">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="241" mass="26769" checksum="01608980B6518EAA" modified="2016-04-13" version="1">MSIICGLPLLECVYCIACARWAWKRCLHTAGHDSETWGVATAEEFEPVPRLCRYILAVYEDDLKCPLWEPLGGYGIDPNCLILKRTYEDTHGRAPPYLLYLDHAHADIVLAIRGLNLASHKDYAVLLDNKLGRRKFDGGYVHNGLLKAAGVVLDAESNTLKDLLERYPSYTLTLTGHSLGSGVAALLAMVVVKNRDKLGNIDRKRVRCYSIAPARCMSLNLAVRYADIISSVVLQASFFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6G8</accession>
    <name>A0A118K6G8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001007">
        <property type="protein sequence ID" value="KVI10650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6G8"/>
    <dbReference type="Gramene" id="KVI10650">
        <property type="protein sequence ID" value="KVI10650"/>
        <property type="gene ID" value="Ccrd_010959"/>
    </dbReference>
    <dbReference type="OMA" id="NAVMMRF"/>
    <dbReference type="OrthoDB" id="1857384at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48165">
        <property type="entry name" value="BNAC03G44900D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48165:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="11855" checksum="FFA036752E4D2986" modified="2016-04-13" version="1">MRRILAMRLNIQNKRKSPKVADESMFGEGNGAEFPNIVDQHTRQGFSNGLSVIYSIVRAPLLLLSCLSSHPHISGAADGVWVSGELARMSEVNHLMVNDSMRYAILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6T7</accession>
    <name>A0A118K6T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000877">
        <property type="protein sequence ID" value="KVI11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6T7"/>
    <dbReference type="Gramene" id="KVI11158">
        <property type="protein sequence ID" value="KVI11158"/>
        <property type="gene ID" value="Ccrd_010435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="79" mass="9000" checksum="76CFBC3FC4C97F09" modified="2016-04-13" version="1" fragment="single">MVIPIPIQALTTLFEVIPLFSKNCVLANWKEKCHFSLFVLREEEFSPIKIFEVLLLVSYAGENLVVICCSSTFHPPCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6W4</accession>
    <name>A0A118K6W4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000477">
        <property type="protein sequence ID" value="KVI11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K6W4"/>
    <dbReference type="Gramene" id="KVI11283">
        <property type="protein sequence ID" value="KVI11283"/>
        <property type="gene ID" value="Ccrd_010308"/>
    </dbReference>
    <dbReference type="OMA" id="XVSSSGK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF686">
        <property type="entry name" value="AMINO ACID TRANSPORTER AVT6A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="25552" checksum="3F5FE2DE120BB186" modified="2016-04-13" version="1">MTVHPIDNELKDPTQMKYIVRQSILLCSTVYVATSIFGFLLFGDHTQDDVLGNFDGDLGIPYSSLINDVVRISYCLHLMLVFPIVFFLLRLNLDGLFFPYAIPIGFDNRRFLMVTSFVMSLIYVGANFIPSIWDAFQFTGETATVSVGFIFSAAVALSFKTKSGCVCVLTVSTXXVSSSGKWDALQISEKAIEMMLLSSSVNCSSRPIVSGAVLLLICCFLDVGLLLQQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAK7</accession>
    <name>A0A124SAK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005850">
        <property type="protein sequence ID" value="KVH87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SAK7"/>
    <dbReference type="Gramene" id="KVH87775">
        <property type="protein sequence ID" value="KVH87775"/>
        <property type="gene ID" value="Ccrd_024940"/>
    </dbReference>
    <dbReference type="OMA" id="INGRYPE"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF37">
        <property type="entry name" value="PGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="9">
        <location>
            <begin position="277"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="439" mass="49366" checksum="9B8E7E13D4C459AA" modified="2016-04-13" version="1">MERVEGLLFYASVEGNVTLLQTLLQEDPLILDRVTVNRCDDMPLHVASMLGHFDFVNEILSRKPQLARESDSQRRLPLHIASAKGHVEIVKALLSAHPETCLARDRDGRNPLHLAAIKGRYQVVKELMQAQPHAARAMVEQETILHLCVKHNQLEVLKLLVGSMGDHEFVNSKDGDGNNILHLAVADKQIETINFLLLDTTIEVNASNTKEETYTDILAQGPKDVKDRQIIRSLTRADAVEPKTEGLIEKIPQKWISKTCLDYKKLFPPIRQKNREDWLDKKRNTLMVVASFIATMAFQVGTNPPSGVWQEDKLDAIPPRHAGYAVMAXNHPVLHHIFLISNTVGFISTLSIILLLISGLRFLKHRGSTWIMIVIMWIATTSLSITYYVSITVTTPKEQAETIRPLSVAILFVWIGLMTVVVGGHMLRLMAMTKEDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCV0</accession>
    <name>A0A124SCV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase RMA</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein RING membrane-anchor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase RMA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_002997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin-protein ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The RING-type zinc finger domain is responsible for E3 ligase activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01004491">
        <property type="protein sequence ID" value="KVH94945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCV0"/>
    <dbReference type="STRING" id="59895.A0A124SCV0"/>
    <dbReference type="Gramene" id="KVH94945">
        <property type="protein sequence ID" value="KVH94945"/>
        <property type="gene ID" value="Ccrd_002997"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="15356" checksum="454D9EAC46DC58AD" modified="2016-04-13" version="1">MLTVKTIDESENSPSGCFHCNICLDTVHDPVVTRCGRLYCWPCIYKWMHQQRTTSEYPDKKNVQCPVCKSEVSQKTIVPLHGRGQTTEPLSDEKGSTASVDVGDLFVTLKSDPPLKCRKRAVDAGDGKAKAKELDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SED1</accession>
    <name>A0A124SED1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003417">
        <property type="protein sequence ID" value="KVH99712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SED1"/>
    <dbReference type="STRING" id="59895.A0A124SED1"/>
    <dbReference type="Gramene" id="KVH99712">
        <property type="protein sequence ID" value="KVH99712"/>
        <property type="gene ID" value="Ccrd_022037"/>
    </dbReference>
    <dbReference type="OMA" id="LQWPLHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF90">
        <property type="entry name" value="MYC-TYPE, BASIC HELIX-LOOP-HELIX (BHLH) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="36186" checksum="920D94F14CEA2354" modified="2016-04-13" version="1">MSCSHFIAYDILEREMALETRLFPQGQIGNFRYDYVLPEDHIFGGFLDGTNNINHHQDSPSAHAYWGNYSSSSPVMHIKDQWDPKSSPEDCTGGDGCDGVILGSSPGNMKVESPTATTPIATATAVGRRKRRRTKSGKNKEELENQRMTHITVERNRRKMMNEYLGVIRSLMPSSYAQRGDQASIVGGAINFVKELEQKLQTLEVQKRGNNGYPPQPPPQPFVDFFAFPQYSLRAAGDGGAGSGGSTKNRPPAMAEIEVTMVESHANLKILSKKRQRQLLKMVAGLQCLWLTILHLNLEDGCQLSTVDEIATAINCLLCRIEEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEL6</accession>
    <name>A0A124SEL6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">fructokinase</fullName>
            <ecNumber evidence="9">2.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_021287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in maintaining the flux of carbon towards starch formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003388">
        <property type="protein sequence ID" value="KVI00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEL6"/>
    <dbReference type="STRING" id="59895.A0A124SEL6"/>
    <dbReference type="Gramene" id="KVI00467">
        <property type="protein sequence ID" value="KVI00467"/>
        <property type="gene ID" value="Ccrd_021287"/>
    </dbReference>
    <dbReference type="OMA" id="NYREDLW"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01167">
        <property type="entry name" value="bac_FRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000005">
        <property type="entry name" value="Probable fructokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050306">
        <property type="entry name" value="PfkB_Carbo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF24">
        <property type="entry name" value="FRUCTOKINASE-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085">
        <property type="entry name" value="HEXOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="14"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="35352" checksum="5271F02EA109901D" modified="2016-04-13" version="1">MAATNGVVKEEGGLIVSFGEMLIDFVPTVSGVSLAEAPGFLKAPGGAPANVAIAVSRLGGKSAFVGKLGDDEFGHMLAGILKENGVCGEGINFDKGARTALAFVTLKADGDREFMFYRNPSADMLLTPDELNLELIRSAKVFHYGSISLIVEPCRSAHLKAMEVAKDAGALLSYDPNLRLPLWPSPEEAREQIMSIWDKAEVIKVSDNELEFLTGCEKIDDEAAMSLWHPNLKLLLVTLGDKGCNYYTKNFHGTVGAFAVKAVDTTGAGDSFVGALLTKIVDDHSVLEDEGKLKELLRYACACGAITTTKKGAIPALPTVSEVQGFIKEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFG2</accession>
    <name>A0A124SFG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002502">
        <property type="protein sequence ID" value="KVI03136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFG2"/>
    <dbReference type="STRING" id="59895.A0A124SFG2"/>
    <dbReference type="Gramene" id="KVI03136">
        <property type="protein sequence ID" value="KVI03136"/>
        <property type="gene ID" value="Ccrd_018568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF17">
        <property type="entry name" value="PHOSPHATASE IMPL1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="20949" checksum="642D1DE695BC81FD" modified="2016-04-13" version="1">MSEAAILSVVRKNFPDHLILGEEGSVIGDSSSDYLWCIDPLVLFRGKPAAAAVVEFVGGAMCWNTRIFSAVAGGGAFCNGQKIHVSQTDKGVRRLGAAAVDMCHVALGIIEAYWEYRLKPWDMAAGVLIVEEAGGTVSRMDGGKLTVFDRSLLVSNGILHAKLLEKIGIATEELKGKGIDFSLWYKPDDYNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103HP48</accession>
    <name>A0A103HP48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009978">
        <property type="protein sequence ID" value="KVE93678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103HP48"/>
    <dbReference type="Gramene" id="KVE93678">
        <property type="protein sequence ID" value="KVE93678"/>
        <property type="gene ID" value="Ccrd_026885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVE93678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15408" checksum="9DCA18247B07478B" modified="2016-04-13" version="1">MRRSYRLQSNKKGSKFSNTTENPVDVENESDKVAILNVVEAKQRVTDCSTRRETICKRPPKSREDSKGDDDFEVQDENIRKKVKCVKGDTKGREDNVKDPIKTHLALRTRTSPKPLYTMIQNLSPSQIVCKINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103IJ75</accession>
    <name>A0A103IJ75_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009775">
        <property type="protein sequence ID" value="KVF14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103IJ75"/>
    <dbReference type="STRING" id="59895.A0A103IJ75"/>
    <dbReference type="Gramene" id="KVF14468">
        <property type="protein sequence ID" value="KVF14468"/>
        <property type="gene ID" value="Ccrd_026854"/>
    </dbReference>
    <dbReference type="OMA" id="MSIIVEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVF14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20853" checksum="C8022A786AFC570E" modified="2016-04-13" version="1" fragment="single">MIKVALCCIRYRPETRPMMSIIVEMLEGALEVPEPLNPFPHLFSELIESGGALTRIAWNGGGSNWSSSEMVTKSTMWFPLWAWRKYEQKQLKELMMVCTIKEKDEEVAERTLKVALCCVQYRPETRPVMSIVVKMLEGALEVPEPLNPFSHLISGVIETGDSLARMAWNVGGSDWSTSEVVTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103LR80</accession>
    <name>A0A103LR80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009013">
        <property type="protein sequence ID" value="KVF80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045344">
        <property type="entry name" value="C-JID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058192">
        <property type="entry name" value="WHD_ROQ1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF573">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20160">
        <property type="entry name" value="C-JID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23282">
        <property type="entry name" value="WHD_ROQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein Roq1-like winged-helix" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C-JID" evidence="3">
        <location>
            <begin position="453"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C-JID" evidence="3">
        <location>
            <begin position="887"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVF80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1054" mass="122383" checksum="DA7A549C1758E30D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103PH72</accession>
    <name>A0A103PH72_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008321">
        <property type="protein sequence ID" value="KVG31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103PH72"/>
    <dbReference type="Gramene" id="KVG31003">
        <property type="protein sequence ID" value="KVG31003"/>
        <property type="gene ID" value="Ccrd_026492"/>
    </dbReference>
    <dbReference type="OMA" id="GCYFVVG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000180">
        <property type="entry name" value="Cytidyltransferase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.20:FF:000003">
        <property type="entry name" value="Os01g0691500 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="234"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="400" mass="43831" checksum="3E8818B5CAF0D721" modified="2016-04-13" version="1">MNQEIGSGQGQQTMTDRWIRAVVEAIHSTPTQAVLYFSGGASQVLGWLSSIPGASNTVLEVIVPYSRMSMIQLLGKVPVQFTSKETAEDMALVAYNRALKLSKPGSPVVGVGFTGSLVTTHPKLGDHRFHLSTRTSNQLWTSSVTLSKGLGRSREQEERVSSQVLLKAIADACKVASTIKFVSDLTEGEVPAVSEQCFNEDQELEQLIHGKICFKVFPFSSGILTTSGERKVILSGSFNPLHNGHLKLLEVAMSLCTDGYPCFELSAINADKPPLTVEEIKDRVKQFEKAGKTVIISNQPYFYKKAELFPGSAFVIGADTAARLINPKYYGGNYENMVETLLGCKNTGCTFLVGGRNMHGVFKVLEDFDIPGELKDMFISIPVDKFRMDISSTDIRKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VLB7</accession>
    <name>A0A103VLB7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006704">
        <property type="protein sequence ID" value="KVH55998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VLB7"/>
    <dbReference type="STRING" id="59895.A0A103VLB7"/>
    <dbReference type="Gramene" id="KVH55998">
        <property type="protein sequence ID" value="KVH55998"/>
        <property type="gene ID" value="Ccrd_025683"/>
    </dbReference>
    <dbReference type="OMA" id="HWIWSTD"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000006">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="51"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH55998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="510" mass="54462" checksum="382B9EE15F7BA779" modified="2016-04-13" version="1">MASPLTCSAVDLTPLLGLAANATAAADYICSRFTAADDQFTNTAYAINNTYLLFSAYLVFAMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGGISYYIFGFAFAFGVPSNGFIGKHNFGLKSIPSEVYDYSFFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPIVSHWVWSTDGWASASRTSGSLLFGSGAIDFAGSGVVHMVGGIAGLWGALIEGPRLGRFDRSGRSVALRGHSGSLVVLGTFLLWFGWYGFNPGSFITISKSYNTSDTFYGQWSAVGRTAVTTTLAGCTAGLTTLFSKRLLVGHWNVTDVCNGLLGGLAAITSGCAVVEPWAAIVCGFVAAWVLIGFNKLAEKLKYDDPLEAAQLHGGCGSWGLLFTGLFAEKQYVHEVYGLGRPYGLFMGGGGKLFAAQIIQILVIIGWVSATMGPLFYALKKLKLLRVSKEDEMAGMDMTRHGGFAYVYHDEDTSSHPPPGFMMRRIEPSGASPAPNNDSTTNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBB1</accession>
    <name>A0A103XBB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006059">
        <property type="protein sequence ID" value="KVH87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBB1"/>
    <dbReference type="STRING" id="59895.A0A103XBB1"/>
    <dbReference type="Gramene" id="KVH87563">
        <property type="protein sequence ID" value="KVH87563"/>
        <property type="gene ID" value="Ccrd_025156"/>
    </dbReference>
    <dbReference type="OMA" id="SESNEDW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="49665" checksum="085974E179F4F549" modified="2016-04-13" version="1">MATIDVKKGDVETKQMIQVLVEKEKERRNHRNNNAPSIYIVDSILRNLSPNSFEPCVVAIGPLHKEDEKLQDMESHKVTYLLDLFLRLPSMPDRKMDECIERVYANVEQIRACYAGKMEAYDDCQVAKMMVIDGCFVLEFILRKFCQPADAKPSGVSVSRFHSVEELTNAGVNFKRNQDKRWPLAMEFKASWFPCFGWAWGKPTFTMPVLYIEDHTESVLRNLIAYEQCSPLSDTYITSYAVAMGMLVDTQEDIVKMVDSKVLINNLGTNRDAANMINNICENVVLQDFCYSQQCNQVGSYYDHCWPKYIAPNMAGLRRTYFSSPWNFVALVAGIILFGLTVIQTYYTEIDFVEEQMADNIHPGLVIAGNRVRKRSERIMIKNYFSKFKNTAANPVVLDEKDLDYHVVNPQAVQSNERIIPVQETDTLLRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD89</accession>
    <name>A0A103XD89_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_026328</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005362">
        <property type="protein sequence ID" value="KVH88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD89"/>
    <dbReference type="STRING" id="59895.A0A103XD89"/>
    <dbReference type="Gramene" id="KVH88603">
        <property type="protein sequence ID" value="KVH88603"/>
        <property type="gene ID" value="Ccrd_026328"/>
    </dbReference>
    <dbReference type="OMA" id="EHNVERP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000292">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000108">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000371">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000560">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF52">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118689" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="18"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="703"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="963" mass="106020" checksum="4AF5E573C2C76825" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDL9</accession>
    <name>A0A103XDL9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Pectinesterase</fullName>
            <ecNumber evidence="4 15">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_025550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 15"/>
    <dbReference type="EMBL" id="LEKV01005336">
        <property type="protein sequence ID" value="KVH88801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDL9"/>
    <dbReference type="STRING" id="59895.A0A103XDL9"/>
    <dbReference type="Gramene" id="KVH88801">
        <property type="protein sequence ID" value="KVH88801"/>
        <property type="gene ID" value="Ccrd_025550"/>
    </dbReference>
    <dbReference type="OMA" id="TIIWINS"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000033">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF33">
        <property type="entry name" value="PECTINESTERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989367" description="Pectinesterase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="16">
        <location>
            <begin position="94"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH88801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="391" mass="43587" checksum="D6F58B8E6DFE2506" modified="2016-04-13" version="1">MTFRYMNVFSLLVALLATTHFLSSNLEFFRFWIEELHVISLSPVSIIVNPYTDWLEGHRHHRDKKAKKFDICDDFPRDSLPPDTNTTTTFCIDRNGCCNFTSIQSAVDAVMTSNPKRTIMWINNGIYFEKVIIPKTKPNITFQGQGYTTTAIVWNDTANSSHGTFYSASVQVFSTNFVAKNISFMNVAPIPKPGDIGAQAVAIRVGGDQAAFWGCGFFGAQDTLHDDRGRHYFKNCYIQGSIDFIFGNAKSLYEDCELISMAPMVAVGQKSINGAVTAHGRASADEDSGFAFVRCNIGGTGRIWLGRAWRPFSKVIFAYTFMSDVIAPEGWNDFNDPSRDQSIFYGEYMCTGGGANTSMRVAYAQKLNDTQASLFLNASFIDGDQWLPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDM2</accession>
    <name>A0A103XDM2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase, superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005332">
        <property type="protein sequence ID" value="KVH88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH88823">
        <property type="protein sequence ID" value="KVH88823"/>
        <property type="gene ID" value="Ccrd_025346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="431" mass="47166" checksum="24002FE8D1D8D94E" modified="2016-04-13" version="1">MMKYAFSNFKNTIDTPVDVDEEPMNTEATGRLVRKKSVKQVKNPSTVIDEPHKGRLVKKDNIPIVDNSIEDATNATKDHHVPSFTGEIGSGKNPMNAGIKRDNDFQTVDQLRETAVNRVTRRGKGLAIGYDKEVPVASDSKDMTFCIRTRTSPKTLYDTVTSLTVAQRAAVKDMGFQSLLDMTLDGIPAKIGFYVVDNLDTAAMNIKMNAGVIPITINSIHEVLGLPMGGLDLNSADPSPCIDDIVTAWRKQFTKDRMRPKDVMNVIXKSADADTLTSLLPVPQPLFLIPDGGRMSASSDKKVAACDKHYVGDGGTHLDTNEGNTIIGFMISDWQCIHRITTPAHANYIFSILAGMNAGIDMPNSHHLDHRQQQQCVASSLCLPPQTGLMTGSSFHHRFAVAAPRSFFNAAMEATNQQTIGSFPPTELTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEE7</accession>
    <name>A0A103XEE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Syntaxin 6, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_008786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005287">
        <property type="protein sequence ID" value="KVH89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEE7"/>
    <dbReference type="STRING" id="59895.A0A103XEE7"/>
    <dbReference type="Gramene" id="KVH89235">
        <property type="protein sequence ID" value="KVH89235"/>
        <property type="gene ID" value="Ccrd_008786"/>
    </dbReference>
    <dbReference type="OMA" id="ERDKSCM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34949:SF6">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34949">
        <property type="entry name" value="OS05G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Syntaxin 6/10/61 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="44695" checksum="3348CDCB01FD87DD" modified="2016-04-13" version="1">MTSHFERWEKDPFFPAAEEVQESADRMESTYRTLLHALKEPSAWKTEELRRDLRTALGTAKWQLEEFERAVDLSYGKSFSDNAKTRHGEFISAMESQISKVERCLDESAVATGKPPRPWVRLNEGESKELALFLSGSASYGNEKLAEVSFNDDQRQKQEVLEQSTPECSKNLSHPVGRGSVDSHANKFSGHRRTASAGADLGALKIVIADDVSLHGVDGKTEQPPRKIPSFSGFLNTLESASKLKWSKNGYRKLKLIDHRHEADIKLPETQTGSRGTNACYERSKSCLESGDDCYRKQLYGWYGAIQRQFQRSQYYVQYNRPTQMVLWALVLIFLFGKFAFLWQNLLVKCHPSSTLTKIDMSHSISYSACHLKQKQKQKRYGLNRQETKGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEH6</accession>
    <name>A0A103XEH6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myeloid leukemia factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005299">
        <property type="protein sequence ID" value="KVH89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEH6"/>
    <dbReference type="STRING" id="59895.A0A103XEH6"/>
    <dbReference type="Gramene" id="KVH89193">
        <property type="protein sequence ID" value="KVH89193"/>
        <property type="gene ID" value="Ccrd_008830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24311" checksum="046010DB6D7FB6C3" modified="2016-04-13" version="1">MQRERHSRDESINSRGPFDGPRGFASHRSMMSGILGGRDPFDDPFFNRPFEGMFGPSIFDTHGPSDLPYPSESSSKGLVIEEIDTDDEEEEGKNGASRSATSGKGPNPTTFHITDHGCLAEEVKKDVRFNGNHNRMEGTKPQTQSISYKKVTYGGINGAYYTATTTRKSGSDGVVLEDSKEANKTTGRATHRISKGIHDKGPVACDHLGWHLSLPTVPIATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFS1</accession>
    <name>A0A103XFS1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005130">
        <property type="protein sequence ID" value="KVH89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFS1"/>
    <dbReference type="STRING" id="59895.A0A103XFS1"/>
    <dbReference type="Gramene" id="KVH89866">
        <property type="protein sequence ID" value="KVH89866"/>
        <property type="gene ID" value="Ccrd_008140"/>
    </dbReference>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080022">
        <property type="term" value="P:primary root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009787">
        <property type="term" value="P:regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900457">
        <property type="term" value="P:regulation of brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900140">
        <property type="term" value="P:regulation of seedling development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="159"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="388" mass="44115" checksum="0F2D2E1B8E0D5539" modified="2016-04-13" version="1">MDGRITELVRATQVHSPSSTTKTPLMNSQLETLWEEVRELSLGTTPQIDRLHTPPTPLQFLRHYLSQNKPFILSASAATTLQWPATTLWTSTSYLRQTLSSSIVSLHLTPTGQADSIATLPSNPDSLCFASAHVQRTPFSDAIDAIEGSHKRDSITGFVAYAQQQNDCFTEEYGALAGDCDSHVAWATEAIGSLPEAVNLWIGNHLSETSFHKDHYENLYAVVTGEKHFVLLPPTDVHRMYIRDYPAAHYSYSQETGEFELELENPVRHVPWCSVNPYPFPENKEKEMSEFPLYYNGPKPFEVTVKAGEILYLPSMWFHHVRQTPDRRGLTIAVNYWYDMQFDIKYAYFNFLQSLSPPQKPTCRKSTSHDNFLTNENESDGDQNRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGJ6</accession>
    <name>A0A103XGJ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005106">
        <property type="protein sequence ID" value="KVH90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGJ6"/>
    <dbReference type="Gramene" id="KVH90346">
        <property type="protein sequence ID" value="KVH90346"/>
        <property type="gene ID" value="Ccrd_007641"/>
    </dbReference>
    <dbReference type="OMA" id="LEWIKYH"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000270">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF51">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="373" mass="41933" checksum="2BD05E2C69F28ADF" modified="2016-04-13" version="1">MAEGKISAAAARSHTRKSKSNSNSFAGILKKLLVVFFAGFAAWAIRPPPPTKLGSSDITTPRIKLRDGRHLSYVEAGVPKDKAKFKVIFVHGFDCNKYFNPFAVAASPALVEELGVYHVSIDRPGYGESDPHPNRTVKSLALDIEEFADHLNLGPRFYVAGYSMGGQVMWSVLKYIPHRLAGAILIAPAINYWWPNLPSDLTNEAFSRQLPQDRWAMRVAHHLPWLTYWWNTRKWLPPFSAIVGNPVIYSPSDVEVFTKLYAATAEDPNKAQKMRSGPRQQGEFESLHRDLNIGSGKWEFDPLDVENPFPNNDGSVHLWMGDDDRIVPVSLERYFAQKLEWIKYHEVAGAGHMMAFQGEVVDAILKASFNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGX5</accession>
    <name>A0A103XGX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGX5"/>
    <dbReference type="STRING" id="59895.A0A103XGX5"/>
    <dbReference type="Gramene" id="KVH90484">
        <property type="protein sequence ID" value="KVH90484"/>
        <property type="gene ID" value="Ccrd_007481"/>
    </dbReference>
    <dbReference type="OMA" id="PEWANFL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF118">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="6">
        <location>
            <begin position="139"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="38858" checksum="4740AEFDEEDFB94D" modified="2016-04-13" version="1">MMLNLNLNLNLSNLMPECMAESGTQFRELCGGSGSGGKLQYSGVTSNSSVVNVEPTSNAGDEEHMYPCLNLEYNFDILKQNNLEDDKNVRSGIFVTKQLFPDGCSSVAERELNLRQQYYQQYNQQIKKNRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAMGSLGGAQSIEELLGINVVDGKPEWANFLGKSEDQYIYLGLFDSEIEAARAYDKTAIKFNGREALTNFEPSSYKGEPTPETENDAYSQSMDLNLGIAPPSFRSSNYTKYTSGSLHQINHLLGDMSEAERTRGTSIEERKEVDLNRGWQLQDPYGGATPASLFSAAASSGFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHA1</accession>
    <name>A0A103XHA1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHA1"/>
    <dbReference type="STRING" id="59895.A0A103XHA1"/>
    <dbReference type="Gramene" id="KVH90680">
        <property type="protein sequence ID" value="KVH90680"/>
        <property type="gene ID" value="Ccrd_007301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010345">
        <property type="term" value="P:suberin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF99">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="182" mass="20385" checksum="3F7BA21EC8DB24F1" modified="2016-04-13" version="1">MEDKRTSGEKRGFVVRITAVFVEKILRVQPNVKKLYLLIRAADAKSALQRFNTEAVAKDLFKLLKEKHGTNLQNFLSEKVTPKCVNIKLFLHVSTAYVSGEKPGLMLETPYYLGDSLNGTSGLDIEEERRIVEDKLKELKSDQNADDKSIKLAMIDLGIGGDDCGALERKYTGGHSTSDHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI06</accession>
    <name>A0A103XI06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinogalactan peptide, AGP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005079">
        <property type="protein sequence ID" value="KVH91095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI06"/>
    <dbReference type="STRING" id="59895.A0A103XI06"/>
    <dbReference type="Gramene" id="KVH91095">
        <property type="protein sequence ID" value="KVH91095"/>
        <property type="gene ID" value="Ccrd_006893"/>
    </dbReference>
    <dbReference type="OMA" id="MVIDQGI"/>
    <dbReference type="OrthoDB" id="777504at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009424">
        <property type="entry name" value="AGP16/20/22/41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33374">
        <property type="entry name" value="ARABINOGALACTAN PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06376">
        <property type="entry name" value="AGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="7822" checksum="F0ABD3209BE4FC08" modified="2016-04-13" version="1">MAATRVFLMALMISIVLAIICPFAQPQSLAPAPAPSSDGTSIDQGIAYGLMIAALLLTYLIHPLDAYGLFSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI93</accession>
    <name>A0A103XI93_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005075">
        <property type="protein sequence ID" value="KVH91133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI93"/>
    <dbReference type="STRING" id="59895.A0A103XI93"/>
    <dbReference type="Gramene" id="KVH91133">
        <property type="protein sequence ID" value="KVH91133"/>
        <property type="gene ID" value="Ccrd_006854"/>
    </dbReference>
    <dbReference type="OMA" id="RSSAWYP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36787">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31947" checksum="3B5B0DCF308D75E0" modified="2016-04-13" version="1">MAQEIETPTSTTASGSENPPNPSSSSKSDPKQLPPFYGFAAPNGELPMFPIMYPTLVPGIYPPQQGQEQMDHGAGIYAVPTFPNSFMGPIAGFPSNHLIPFTYNVPTSGPSPSEAGTGGEEQGQVGQQQQQQGGQQRQVVVRRFQIAIHLDLLLILKLAAVIFLFNQDGSRKRLVLLIFFASLIYLYQTGALAPLIRWLSQGMQRAAAPPQQPRPAARADNAPAAARQENENAPLVAGAAENENRVAGDVNQGENEREHGGELNGNNRWWGIVKEIQLIVFGFITSLLPGFHNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIR5</accession>
    <name>A0A103XIR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger, RING/FYVE/PHD-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004933">
        <property type="protein sequence ID" value="KVH91515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIR5"/>
    <dbReference type="STRING" id="59895.A0A103XIR5"/>
    <dbReference type="Gramene" id="KVH91515">
        <property type="protein sequence ID" value="KVH91515"/>
        <property type="gene ID" value="Ccrd_006466"/>
    </dbReference>
    <dbReference type="OMA" id="CIFCRAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012866">
        <property type="entry name" value="DUF1644"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31197">
        <property type="entry name" value="OS01G0612600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31197:SF4">
        <property type="entry name" value="OS02G0150900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07800">
        <property type="entry name" value="DUF1644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33236" checksum="06EA21E4A055DC5F" modified="2016-04-13" version="1">MEGFQIDTKWEDVICPICLSFPHNCVLLQCSSYDKGCRPFVCDTDHLHSNCLDRFRIANGMLPGSDLTTEATSIANSVTTTAEATSRSSCPLCRGDVTGWVVVNEARVRLDEKKRCCEDEQCTFTGTYMELRKHAKVEHPHACPSKIDPARQLDWENFQQSSEIIDVLSTIHSEVPHGVVLGDYVIEYGDNDSGDEFEDFPGDDGNWWTSCILYQVFDNFRSSRNRRRSRVIESRRESRRLSYDTSNSDEGSVVSTEFAEYRADEAEDEFVTSSSISRGRTGHRRWASFSCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIU8</accession>
    <name>A0A103XIU8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flowering-promoting factor 1-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIU8"/>
    <dbReference type="STRING" id="59895.A0A103XIU8"/>
    <dbReference type="Gramene" id="KVH91591">
        <property type="protein sequence ID" value="KVH91591"/>
        <property type="gene ID" value="Ccrd_006386"/>
    </dbReference>
    <dbReference type="OMA" id="RYYENAH"/>
    <dbReference type="OrthoDB" id="612242at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039274">
        <property type="entry name" value="FPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33433">
        <property type="entry name" value="FLOWERING-PROMOTING FACTOR 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12323" checksum="67170956A2054546" modified="2016-04-13" version="1">MSGVWVFKNGVVRLVENPGAGSLQGASRGKVLVHLPTNEVVTSYQVLEQMLTSIGWERYYDDPQLFQFHKRSTVHLISLPKDFKKLKSMHMYDIVVKNRNVFEVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKI0</accession>
    <name>A0A103XKI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XKI0"/>
    <dbReference type="Gramene" id="KVH92451">
        <property type="protein sequence ID" value="KVH92451"/>
        <property type="gene ID" value="Ccrd_005515"/>
    </dbReference>
    <dbReference type="OMA" id="MDLIDTW"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000127">
        <property type="entry name" value="Probable glycosyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF46">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="458" mass="52902" checksum="CB145B405F8C780A" modified="2016-04-13" version="1">MKSPEIYQSQFSAPMARNNGGGRRSSLSIASDAFIFFSGAVAALLLVWTFSTFSNPQPQPTPNFETRIPDPKSSVIDNAGCAGSSSGFNLQYDPPDPTFYDDPTIGYTLDKPIKNWDEKRREWLKQHPSFEPGSDERILVISGSQSGPCSNPIGDHLLLRFFKNKVDYCRRHGYDILYNNVLLHPKMHTYWAKIPSVRAAMLAHPEAEWIWWVDSDAAFTDMDFKLPLKRYKDHNFVVHGWPKLIYEKKSWTSLNAGVFLIRNSQWALDFMDVWSGMGPQTPNYEKWGXILRETCKDKFFPESDDQTGLVYLLLKEKEKWGNKIYVEGEYYFEGYWLEIVETLENITAKYNGVEREVRRLRRRHGEKVSDGYSALWEEYLKDAGFGKFSWRRPFITHFTGCQPCSGQHNQMYSGQSCWDAMQKVLNFADNQVLRNYGFVHRDLLDSASVSPLPFNYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLU2</accession>
    <name>A0A103XLU2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PC-Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004794">
        <property type="protein sequence ID" value="KVH93121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLU2"/>
    <dbReference type="STRING" id="59895.A0A103XLU2"/>
    <dbReference type="Gramene" id="KVH93121">
        <property type="protein sequence ID" value="KVH93121"/>
        <property type="gene ID" value="Ccrd_004812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF30">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118909" evidence="7">
        <location>
            <begin position="29"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48662" checksum="4863BE8745A448B9" modified="2016-04-13" version="1">MGFNHKDLRLFVVVVVVVIMNMVENSEGKTMGCDVFQGNWVIDQSYPPYNASSTCPFVGTEFNGLSFLEKLRGKTIMFVGDSLSKNQWLSLLCMIHSSVPSASYVVKMRGAEGITTYNFTEIENLFDDTDYGVKVVYHHSLYLVDIVREKIGRVLKLDSITSGNLWLGVDYLVFNTFGGGGGGGGGNGVDGDERRCDLFKGRWLWDESDSNPMYTGSECPFINPGLNCQKNGRADNMYLNFRWQPHGCSLPRGKKIMFVGDSLSSNQWQSLACMLYNPTRRSNPSLTHQGQLSTISFPEHGVSIMYLKNGFLVDLEVEKKGRVLKLDSISKGRIWEEADILIFNSYHWNCDGQTEPILGFSYPGKKYAAEQVVKDVLAKMKNPAYLLDITLLTQLRKDGHPSKYAGGMTDCSHWCLAGVPDTWNQILYTILLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNA5</accession>
    <name>A0A103XNA5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004586">
        <property type="protein sequence ID" value="KVH93906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNA5"/>
    <dbReference type="Gramene" id="KVH93906">
        <property type="protein sequence ID" value="KVH93906"/>
        <property type="gene ID" value="Ccrd_004036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="71" mass="8079" checksum="5E2249823B6517BE" modified="2016-04-13" version="1">MLEGKAYVKDTHMPLKMKVHAMDSPLLPTSRRVQPSFQPVFHTPPIELQDRSLSNNPETVSRSGFSFEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNC8</accession>
    <name>A0A103XNC8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004600">
        <property type="protein sequence ID" value="KVH93793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNC8"/>
    <dbReference type="STRING" id="59895.A0A103XNC8"/>
    <dbReference type="Gramene" id="KVH93793">
        <property type="protein sequence ID" value="KVH93793"/>
        <property type="gene ID" value="Ccrd_004156"/>
    </dbReference>
    <dbReference type="OMA" id="LLNCGCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01958">
        <property type="entry name" value="HPS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027923">
        <property type="entry name" value="Hydrophob_seed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051636">
        <property type="entry name" value="Plant_LTP/defense-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14547">
        <property type="entry name" value="Hydrophob_seed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118965" evidence="2">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrophobic seed protein" evidence="3">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="24623" checksum="BFC662AE434807C6" modified="2016-04-13" version="1">MESSKHQLTALLLVSMVFISSATPIALDCVPCGRGKPPHHTSKPHNPHKPPSGKPPTTHPPIVRPPIVRPPIVRPPIVRPPVVRPPVVNPPITLPPVVRPPITLPPIVKPPITLPPVVNPPITLPPVLNPPSGGKPGTPCPPPPFVPAPAPTCPIDALKLGACVDLLGGLVHIGLGDPVVNQCCPILAGLVELEAAVCLCTTLKIKLLNINIYLPLALQLLITCGKTPPPGVMKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNQ6</accession>
    <name>A0A103XNQ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNQ6"/>
    <dbReference type="STRING" id="59895.A0A103XNQ6"/>
    <dbReference type="Gramene" id="KVH93988">
        <property type="protein sequence ID" value="KVH93988"/>
        <property type="gene ID" value="Ccrd_003948"/>
    </dbReference>
    <dbReference type="OMA" id="FPFMEIT"/>
    <dbReference type="OrthoDB" id="1929225at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098:SF71">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="71301" checksum="21B00E72DA2BF2BA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQR3</accession>
    <name>A0A103XQR3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily domain, general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQR3"/>
    <dbReference type="Gramene" id="KVH95132">
        <property type="protein sequence ID" value="KVH95132"/>
        <property type="gene ID" value="Ccrd_002771"/>
    </dbReference>
    <dbReference type="OMA" id="CSYFIHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37891">
        <property type="entry name" value="OS06G0113900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37891:SF1">
        <property type="entry name" value="OS06G0113900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60281" checksum="A1043CF0BA2BD352" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS34</accession>
    <name>A0A103XS34_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS34"/>
    <dbReference type="STRING" id="59895.A0A103XS34"/>
    <dbReference type="Gramene" id="KVH95867">
        <property type="protein sequence ID" value="KVH95867"/>
        <property type="gene ID" value="Ccrd_002054"/>
    </dbReference>
    <dbReference type="OMA" id="IHEMGST"/>
    <dbReference type="OrthoDB" id="752507at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF63">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="234" mass="26754" checksum="8C9DB564F768E29D" modified="2016-04-13" version="1">MERKNKCSGSGSGSGSLKMKKPERKITEKNRRNNMNFLYSHLFSLIPPHLISKGGAQVSDRVDRAIDYIQTLKDSLEMNKKKKEQLLSKKRSFQHTKTNIVRQSLDVQIQEMSPDLDAVLVTGLKNHSDFCDVVQLLERYSTEVALANFSSSGHSIFHLRHKKMEADEMSKRIKNLIEGSSKMKELELELELGNDDIDINGSSSSSSNISKWDFDIQSTLWEWELEMLPMNMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS42</accession>
    <name>A0A103XS42_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Plastid</location>
            <location evidence="8">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS42"/>
    <dbReference type="STRING" id="59895.A0A103XS42"/>
    <dbReference type="Gramene" id="KVH95878">
        <property type="protein sequence ID" value="KVH95878"/>
        <property type="gene ID" value="Ccrd_002017"/>
    </dbReference>
    <dbReference type="OMA" id="SHECVIL"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="19903" checksum="4D682476E2F25DAC" modified="2016-04-13" version="1">MVGQFAKPRSNSFEEKDGVKLPSYRGDNVNGDAFDLKSRTLDPQRLIRAYCQSAATLNLLRDFATGGYAAMQRVTQWNLDFTEQSEQGDSRVDEALGFMSAVGLTVDHPIMTTTDFWTSHECLHLPYEQSLTRLDSTSSLYYDCSAHFLWAGERTRQLDGAHVEFLRGIANPLGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTK9</accession>
    <name>A0A103XTK9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WDR11 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004257">
        <property type="protein sequence ID" value="KVH96665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTK9"/>
    <dbReference type="STRING" id="59895.A0A103XTK9"/>
    <dbReference type="Gramene" id="KVH96665">
        <property type="protein sequence ID" value="KVH96665"/>
        <property type="gene ID" value="Ccrd_001250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="1">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="93" mass="10702" checksum="7836F7E6104E3220" modified="2016-04-13" version="1" fragment="single">MDTLQEKWVLEKEVLEKDLEVYLKSRQGSFRTDKFPGTLVLELDWLPVRTDKNDPLVLCIAGADSSFRLIQVNMYASHLTKLAEQLALFSCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTV8</accession>
    <name>A0A103XTV8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004171">
        <property type="protein sequence ID" value="KVH96812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTV8"/>
    <dbReference type="STRING" id="59895.A0A103XTV8"/>
    <dbReference type="Gramene" id="KVH96812">
        <property type="protein sequence ID" value="KVH96812"/>
        <property type="gene ID" value="Ccrd_001096"/>
    </dbReference>
    <dbReference type="OMA" id="QMREMDL"/>
    <dbReference type="OrthoDB" id="1928656at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11747" checksum="A05844682E16CB3B" modified="2016-04-13" version="1">MARMEGKEDVSSATAVLLGALAPGVNGPTWNTLKAAFLMLGVCLCAMLGLAFSSSDSTLVLHVTLLVLITGTLFFLLSGFLAQTGLVSVEDQMQEIGLGTPNQADRGTTDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU57</accession>
    <name>A0A103XU57_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004049">
        <property type="protein sequence ID" value="KVH96929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU57"/>
    <dbReference type="STRING" id="59895.A0A103XU57"/>
    <dbReference type="Gramene" id="KVH96929">
        <property type="protein sequence ID" value="KVH96929"/>
        <property type="gene ID" value="Ccrd_000978"/>
    </dbReference>
    <dbReference type="OMA" id="WRTQIKQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932:SF2">
        <property type="entry name" value="OS10G0484300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="623" mass="71091" checksum="F04779029CC55FE0" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVG2</accession>
    <name>A0A103XVG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_000273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003824">
        <property type="protein sequence ID" value="KVH97624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVG2"/>
    <dbReference type="STRING" id="59895.A0A103XVG2"/>
    <dbReference type="Gramene" id="KVH97624">
        <property type="protein sequence ID" value="KVH97624"/>
        <property type="gene ID" value="Ccrd_000273"/>
    </dbReference>
    <dbReference type="OMA" id="CENSARK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF90">
        <property type="entry name" value="OS07G0574100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119149" evidence="11">
        <location>
            <begin position="31"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="356"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH97624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="633" mass="68850" checksum="32E85B424C087D27" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWG2</accession>
    <name>A0A103XWG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003807">
        <property type="protein sequence ID" value="KVH98163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWG2"/>
    <dbReference type="STRING" id="59895.A0A103XWG2"/>
    <dbReference type="Gramene" id="KVH98163">
        <property type="protein sequence ID" value="KVH98163"/>
        <property type="gene ID" value="Ccrd_023614"/>
    </dbReference>
    <dbReference type="OMA" id="TCAFLME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF10">
        <property type="entry name" value="ANGELICIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119162" evidence="10">
        <location>
            <begin position="31"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="502" mass="56679" checksum="55344737A8817AF9" modified="2016-04-13" version="1">MLTFLLNPFLLPFVILLFIKWQFFPPKTTGNPPPSPLKLPIIGNFHQLGTLPHQSLRSLSIRYGPLMLIHLGNVPTVVASSADAACEIMKTHDIVFASRPESKLAKKLLYDCKTVSAAPYGDHWRQLKSIMVLQLLSTKRVRFFRSVRAKETALLLEIIDDLDNKPVNLSDLFVTYTNNVTCEVVLGRKYGEGPNGKKFKQLLREFLVTLGSVNIGDFIPCLAWVDRVNGSDREVERIAREIDEFVEGVVEERKKKHRDTAGNVVDYDNFVDIVLKIQQDETDGILLDKTNIKALLLDAYTAGTDTTATVLEWVMAELLRHPNIMKKARDEVRGVSGSKTGLAEEDIEKMTYLKAVIKETLRLHPPLPLLVPNIASKDVRVMGYDIPKGTTVMTNVWAIGRDPKLWDEPQEFRPERFLGSSIDFKGHDFELIPFGAGRRICPGIVFAMATNENLIANLLYKYDWKLANGEIGEDLDMTECPGVAVRKRLLDLEDNERLVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX60</accession>
    <name>A0A103XX60_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_023278</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003794">
        <property type="protein sequence ID" value="KVH98503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX60"/>
    <dbReference type="STRING" id="59895.A0A103XX60"/>
    <dbReference type="Gramene" id="KVH98503">
        <property type="protein sequence ID" value="KVH98503"/>
        <property type="gene ID" value="Ccrd_023278"/>
    </dbReference>
    <dbReference type="OMA" id="EIGSMQN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000691">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052592">
        <property type="entry name" value="LRR-RLK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054:SF12">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="783"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVH98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117711" checksum="1A3E3C2870C77519" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXJ2</accession>
    <name>A0A103XXJ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003763">
        <property type="protein sequence ID" value="KVH98702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXJ2"/>
    <dbReference type="Gramene" id="KVH98702">
        <property type="protein sequence ID" value="KVH98702"/>
        <property type="gene ID" value="Ccrd_023074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35707">
        <property type="entry name" value="OS06G0608100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35707:SF1">
        <property type="entry name" value="SPC7 KINETOCHORE PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="159" mass="17401" checksum="A12162603AB5E64A" modified="2016-04-13" version="1">MDSTAFSMHFHSLARSNSEAELKTSTGVHLSFEAKTPTQDSIPTNTGTPMLMTLAKKPNYQPIVSTSKSSTCFESNDMSIDGEYHNKYDYGELSPTLDALLAEGNKDLHVISPSNGSILKSPRNTETTKEDGGNFMDFSCEKDKKGNITHDMVNEAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYG6</accession>
    <name>A0A103XYG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem I reaction center subunit V, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PSI-G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_022551</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PsaG/PsaK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003630">
        <property type="protein sequence ID" value="KVH99212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYG6"/>
    <dbReference type="STRING" id="59895.A0A103XYG6"/>
    <dbReference type="Gramene" id="KVH99212">
        <property type="protein sequence ID" value="KVH99212"/>
        <property type="gene ID" value="Ccrd_022551"/>
    </dbReference>
    <dbReference type="OMA" id="AYWILAT"/>
    <dbReference type="OrthoDB" id="494978at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030093">
        <property type="term" value="C:chloroplast photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009780">
        <property type="term" value="P:photosynthetic NADP+ reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042550">
        <property type="term" value="P:photosystem I stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.40:FF:000002">
        <property type="entry name" value="Photosystem I reaction center subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.40">
        <property type="entry name" value="Chlorophyll a-b binding protein like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017494">
        <property type="entry name" value="PSI_PsaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000549">
        <property type="entry name" value="PSI_PsaG/PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023618">
        <property type="entry name" value="PSI_PsaG/PsaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016370">
        <property type="entry name" value="PSI_PsaG/PsaK_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03051">
        <property type="entry name" value="PS_I_psaG_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34195:SF1">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT V, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34195">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT V, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01241">
        <property type="entry name" value="PSI_PSAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002912">
        <property type="entry name" value="PSI_PsaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01026">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH99212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16300" checksum="43B708D6445E5FB4" modified="2016-04-13" version="1">MASAFLSAPTFQGLRPLNKTTDSPNSLFLSTKPNFSIAPKKKFNCGVKAELLNPSLVISLSTGLSLFLGRFVFFNFQRENVAKQGLPEQNGVTHFEAGDTRAKEYVSLLKSNDPVGFNIVDVLAWGSIGHIVAYYILATSSNGYDPNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0G6</accession>
    <name>A0A103Y0G6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003397">
        <property type="protein sequence ID" value="KVI00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0G6"/>
    <dbReference type="Gramene" id="KVI00186">
        <property type="protein sequence ID" value="KVI00186"/>
        <property type="gene ID" value="Ccrd_021563"/>
    </dbReference>
    <dbReference type="OMA" id="ARWIRNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF114">
        <property type="entry name" value="PLECKSTRIN DOMAIN, START DOMAIN, PROTEIN ENHANCED DISEASE RESISTANCE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="537" mass="61093" checksum="3F581CD2643BAEAD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0Q6</accession>
    <name>A0A103Y0Q6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y0Q6"/>
    <dbReference type="Gramene" id="KVI00404">
        <property type="protein sequence ID" value="KVI00404"/>
        <property type="gene ID" value="Ccrd_021324"/>
    </dbReference>
    <dbReference type="OMA" id="WASNNIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057554">
        <property type="entry name" value="SAC9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057557">
        <property type="entry name" value="SAC9_C8D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057555">
        <property type="entry name" value="SAC9_GBDL_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057553">
        <property type="entry name" value="SAC9_GBDL_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817:SF2">
        <property type="entry name" value="SAC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24765">
        <property type="entry name" value="SAC9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24791">
        <property type="entry name" value="SAC9_C8D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24790">
        <property type="entry name" value="SAC9_GBDL_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24789">
        <property type="entry name" value="SAC9_GBDL_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="159"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1557" mass="172092" checksum="80BBBC6022296282" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1G8</accession>
    <name>A0A103Y1G8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium-transporting P-type ATPase, N-terminal autoinhibitory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003256">
        <property type="protein sequence ID" value="KVI00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1G8"/>
    <dbReference type="STRING" id="59895.A0A103Y1G8"/>
    <dbReference type="Gramene" id="KVI00787">
        <property type="protein sequence ID" value="KVI00787"/>
        <property type="gene ID" value="Ccrd_020959"/>
    </dbReference>
    <dbReference type="OMA" id="YIVRSHN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000026">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF448">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="731" mass="81047" checksum="463D7D78185AD373" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1Y1</accession>
    <name>A0A103Y1Y1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase A1</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003139">
        <property type="protein sequence ID" value="KVI01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1Y1"/>
    <dbReference type="Gramene" id="KVI01028">
        <property type="protein sequence ID" value="KVI01028"/>
        <property type="gene ID" value="Ccrd_020713"/>
    </dbReference>
    <dbReference type="OMA" id="WKLLDHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000065">
        <property type="entry name" value="Phospholipase A1-II 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033556">
        <property type="entry name" value="PLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828:SF1">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="420" mass="46966" checksum="ECB0BAAED476B2AD" modified="2016-04-13" version="1">MSFIHRRKKQGKDTDVREHMDNNIAKKWKTLSGDTNWKGLLDPLGPDLRNYIIHYGEMAQATYDAFNSVKVSKYAGSSRYARKNLFSRVGISQGRPLNKYRVSKYIYATSSVAVPDAFITKSLSREAWSKESNWMGFVAVATDDGKAVLGRRDIVIAWRGTIQTLEWVNDFGFALVSGPKIFGENNNDDPKIHQGWYSIYTTDDPRSPYNKTSARDQVVAEVKKLVEQYKNEEISLTITGHSLGAAIATLNAIDVIVNGLNKPKDMPNKACPVTVFAFASPRVGDSNFRKVFNSQTDLRALRIRNASDVVPNYPLIGYSDVGIELGIDTTQSEYLKSPGSLSSWHSLEGYMHGVAGTQGSKGGFKLEVSRNISLVNKHLDGLKDEYGVPVSWWCEKNNSMVQQEDGSWELIDHEDDNFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3E9</accession>
    <name>A0A103Y3E9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LNK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002682">
        <property type="protein sequence ID" value="KVI01820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3E9"/>
    <dbReference type="STRING" id="59895.A0A103Y3E9"/>
    <dbReference type="Gramene" id="KVI01820">
        <property type="protein sequence ID" value="KVI01820"/>
        <property type="gene ID" value="Ccrd_019899"/>
    </dbReference>
    <dbReference type="OMA" id="WRVGEFE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039928">
        <property type="entry name" value="LNK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33334">
        <property type="entry name" value="PROTEIN LNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33334:SF8">
        <property type="entry name" value="PROTEIN LNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43767" checksum="155038898E499943" modified="2016-04-13" version="1">MDLKFPCSESSALTNMSQDNGPHESDNRSSFVSESEDQFKLKDQKKQSKQQNQTEGKKAGRCVVNYGLKSNDIRLSSSDESDQVFTSIGNWQQNKSLEHDSFRYKQSSSYLHSGHDHVPMQTNGAQVMTGIKSENKGLAAPFRKEASNATNQVHSVESLGDSLFQGAAFEISERRKVHHAHASQPSLSGNQKQMGMMLQASGNDLFSSQKQFHILEKKPESQNDMEEVKKGASAELAMIGVPEGSSISSEVDEISLEATSFLQLQQVMEQLDLSTKLCIRDSLYRLARSAEQRHNYAGIRDRTTNCGATDGPLMTEGTDKCTGFMDIETDTNPIDRTIAHLLFHRPSDSSNKPTPLPLKPNTKVHGSTTGPPMVAEELSYEEGANESDDKISNSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3G2</accession>
    <name>A0A103Y3G2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_019892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002682">
        <property type="protein sequence ID" value="KVI01819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3G2"/>
    <dbReference type="Gramene" id="KVI01819">
        <property type="protein sequence ID" value="KVI01819"/>
        <property type="gene ID" value="Ccrd_019892"/>
    </dbReference>
    <dbReference type="OMA" id="ATDWITN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015145">
        <property type="term" value="F:monosaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17361">
        <property type="entry name" value="MFS_STP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000002">
        <property type="entry name" value="Sugar transport protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044778">
        <property type="entry name" value="MFS_STP/MST-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF44">
        <property type="entry name" value="SUGAR TRANSPORT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="756" mass="82883" checksum="D6F6C92E4F03D237" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3J9</accession>
    <name>A0A103Y3J9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002676">
        <property type="protein sequence ID" value="KVI01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3J9"/>
    <dbReference type="STRING" id="59895.A0A103Y3J9"/>
    <dbReference type="Gramene" id="KVI01855">
        <property type="protein sequence ID" value="KVI01855"/>
        <property type="gene ID" value="Ccrd_019865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641:SF1">
        <property type="entry name" value="GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641">
        <property type="entry name" value="PERIAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23602" checksum="2833F9BEB0DF005C" modified="2016-04-13" version="1">MATIKLFWHRIFCKKRKKRCGRGDGNIKGGTKASEDETRNATGYMCKSDKKNERLNKQIPGHVKKGAWGKTCNTPVSIQQQIPHHLADRERELVMLQIAMSKELISLPPISKPSPLKELLPQLSSSSEIKKNLFFQTSGEGQEKPTVPEIPKPTIPEIPKPALPELPKPELPTLPKPEVPKVPEIHDLPKPTLPTIPELPKDFPIPSLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4I8</accession>
    <name>A0A103Y4I8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002653">
        <property type="protein sequence ID" value="KVI02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4I8"/>
    <dbReference type="STRING" id="59895.A0A103Y4I8"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="14113" checksum="23703F5F8825513F" modified="2016-04-13" version="1">MWGLDLKKTILWRVSLLRRCARSLWHQILACWIGKSICYRHLLHSGSGPLIPTSHRRPRRPERTTTAMDVATVYHQFPSVEMTASSGDGLASGEMTSSCGGSDHDKEVSDLVALKISLLDYVFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y557</accession>
    <name>A0A103Y557_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein, ACBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002644">
        <property type="protein sequence ID" value="KVI02712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y557"/>
    <dbReference type="STRING" id="59895.A0A103Y557"/>
    <dbReference type="Gramene" id="KVI02712">
        <property type="protein sequence ID" value="KVI02712"/>
        <property type="gene ID" value="Ccrd_019000"/>
    </dbReference>
    <dbReference type="OMA" id="CIDLMAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF105">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="376" mass="41624" checksum="5FA91F223AB9D7A7" modified="2016-04-13" version="1" fragment="single">RIYFTPIRKIPFYPVISFNHQKKFGINLPFFEPLWRFEPSLSLATAMELFQELVFTISLSLIVSLLVVKLFSMASGGDDGNSTVSKRVEEKIEKEWVVCDSEKEEKAGYFEDAVEVSKDVVCGGYVEAELGSGCVMEDTKSVGEVGASYVFDESPERTDFKDASVGLVKSGEVNVSGSSIQEDCMKSIVLQQESIAVDGGDDGGEVKIEEGDGILYDDWQGIETTELEKDFGAAVAFMGSKISADRVSLIDNEVKLQFYGLHKVALEGPCFESQPMALKISARDNWNAWKRLENLGRDEAMAQYIALLSRHVPDWMGNHASEDDMQDFIATRISGKLHSDEETPIGAESERTLEQMNPCIDLMAVEGSTIIIGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y598</accession>
    <name>A0A103Y598_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002630">
        <property type="protein sequence ID" value="KVI02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y598"/>
    <dbReference type="STRING" id="59895.A0A103Y598"/>
    <dbReference type="Gramene" id="KVI02783">
        <property type="protein sequence ID" value="KVI02783"/>
        <property type="gene ID" value="Ccrd_018927"/>
    </dbReference>
    <dbReference type="OMA" id="ETPNFFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18975" checksum="75D105DD90AAC468" modified="2016-04-13" version="1">MGNYVSCTLTHQDGKFSRATKVIFPNNEIRRFREPIKAAEVMMESPNSFIVHSKSLRVGARFSALNADEDLEFASVYVMFPMNKVNAVITTADLGFLFITAKKIDDRRICIENVPTPLKSRLEDTEEMSSLEFKHRISTCRSKKPLLDTIVEEQVCSRWWKPCCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y735</accession>
    <name>A0A103Y735_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y735"/>
    <dbReference type="STRING" id="59895.A0A103Y735"/>
    <dbReference type="Gramene" id="KVI03729">
        <property type="protein sequence ID" value="KVI03729"/>
        <property type="gene ID" value="Ccrd_017976"/>
    </dbReference>
    <dbReference type="OMA" id="MIVDMAS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132">
        <property type="entry name" value="EMB|CAB87627.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13566" checksum="00CD7AC66851596E" modified="2016-04-13" version="1">MCPLRIILIFLSATLAGFFVLRNFKSQSNFSDTDEDSTASKSSPDSSSSCVGWSSSKVYGAFVNGFWTCVDMASGRYLWRNLGGTRVDTNIRFDHPLLYFQRNIRSTYPGYNNQSLVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7D8</accession>
    <name>A0A103Y7D8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7D8"/>
    <dbReference type="STRING" id="59895.A0A103Y7D8"/>
    <dbReference type="Gramene" id="KVI03882">
        <property type="protein sequence ID" value="KVI03882"/>
        <property type="gene ID" value="Ccrd_017836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044701">
        <property type="entry name" value="MRL7/MRL7L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34669:SF2">
        <property type="entry name" value="THIOREDOXIN-LIKE FOLD DOMAIN-CONTAINING PROTEIN MRL7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34669">
        <property type="entry name" value="THIOREDOXIN-LIKE FOLD DOMAIN-CONTAINING PROTEIN MRL7L, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="258" mass="29459" checksum="337492FD435176EE" modified="2016-04-13" version="1">MALNSNLNLHSFTPLSTHTNSIRFPASISKIGYIFRPPILRAISKNSDVNLEDDRKPQKNSRSRRRLNPEISENSKNDEEKPFPSTIPRKPRRGRRSEAAAVEDFMRDSLEETFAAISEQNSEVMGGREDVIKDRLEEIDDGGGGDDEEDGGGGGEKNKKGMVVEEEDPDWPVDAEVGWGIRASEYFEKHPIKNVMGEDGVEIDWEGELDDNLVNEINSLEWESFAFHPSPLIVLVFERYNRYVCLRKFRPYVYSFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7U8</accession>
    <name>A0A103Y7U8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01002309">
        <property type="protein sequence ID" value="KVI04118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7U8"/>
    <dbReference type="STRING" id="59895.A0A103Y7U8"/>
    <dbReference type="Gramene" id="KVI04118">
        <property type="protein sequence ID" value="KVI04118"/>
        <property type="gene ID" value="Ccrd_017593"/>
    </dbReference>
    <dbReference type="OMA" id="FNQDMQM"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="18196" checksum="CD5C2FFCA97E6A79" modified="2016-04-13" version="1">MGNPTVFFDMTVGGAKVGKIVMELYADTTPRTAENFRALCTGEKGVGSSGKPLHFKGSSFHRVIPNFMCQGGDFTRGNGTGGESIYGSKFKDENFIKKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVIEGMDVVKTIEKVGSGSGTTSKPVVICDCGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y938</accession>
    <name>A0A103Y938_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001908">
        <property type="protein sequence ID" value="KVI04799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y938"/>
    <dbReference type="STRING" id="59895.A0A103Y938"/>
    <dbReference type="Gramene" id="KVI04799">
        <property type="protein sequence ID" value="KVI04799"/>
        <property type="gene ID" value="Ccrd_016879"/>
    </dbReference>
    <dbReference type="OMA" id="CVTMPIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048768">
        <property type="term" value="P:root hair cell tip growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="252" mass="27943" checksum="BB2954C1A66745D1" modified="2016-04-13" version="1">MSIEIKLSRSNRTYRPDELLQGNIITKLPSSISHRGIQLTINGSVNLQVRGGSAGLIESLYGVLKPIRIVKKSIEVQPSGKISAGTTQIPFSMILKNQGEEHKFYETFHGANISIQYLLNVDVVRGYLHKSLSATVEFIIESDLASLPEKPVSPEMVFFYITQDTQRHSLLTELKSGGFKISGRICTQCLLSDPLVGELTVEASAVPIYSIDIHLLRIESIMVGEKIATETSIIQTTQAQSFFMLRNLSYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y974</accession>
    <name>A0A103Y974_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_016833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Mediates endocytosis and is required for a correct polar distribution of PIN auxin transporters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <location evidence="8">Coated pit</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001905">
        <property type="protein sequence ID" value="KVI04842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y974"/>
    <dbReference type="Gramene" id="KVI04842">
        <property type="protein sequence ID" value="KVI04842"/>
        <property type="gene ID" value="Ccrd_016833"/>
    </dbReference>
    <dbReference type="OMA" id="WLKEDKX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF34">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="10">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="517"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="710"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="817"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1378" mass="155553" checksum="D9A4A13F22707961" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9L6</accession>
    <name>A0A103Y9L6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glucosamine inositolphosphorylceramide transferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_016617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9L6"/>
    <dbReference type="STRING" id="59895.A0A103Y9L6"/>
    <dbReference type="Gramene" id="KVI05051">
        <property type="protein sequence ID" value="KVI05051"/>
        <property type="gene ID" value="Ccrd_016617"/>
    </dbReference>
    <dbReference type="OMA" id="RPEKHAR"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000004">
        <property type="entry name" value="Glucosamine inositolphosphorylceramide transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000095">
        <property type="entry name" value="Glycosyltransferase family protein 64 protein C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056442">
        <property type="entry name" value="GINT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24793">
        <property type="entry name" value="GINT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosamine inositolphosphorylceramide transferase 1 N-terminal" evidence="16">
        <location>
            <begin position="73"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="15">
        <location>
            <begin position="484"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI05051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="732" mass="83279" checksum="BC90FEC7B6C3F3E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9M2</accession>
    <name>A0A103Y9M2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9M2"/>
    <dbReference type="STRING" id="59895.A0A103Y9M2"/>
    <dbReference type="Gramene" id="KVI05060">
        <property type="protein sequence ID" value="KVI05060"/>
        <property type="gene ID" value="Ccrd_016582"/>
    </dbReference>
    <dbReference type="OMA" id="DGLSHRH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31115">
        <property type="entry name" value="OS05G0107300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31115:SF2">
        <property type="entry name" value="OS05G0107300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115162" checksum="0DAEAEB167B23D27" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAL1</accession>
    <name>A0A103YAL1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAL1"/>
    <dbReference type="STRING" id="59895.A0A103YAL1"/>
    <dbReference type="Gramene" id="KVI05570">
        <property type="protein sequence ID" value="KVI05570"/>
        <property type="gene ID" value="Ccrd_016076"/>
    </dbReference>
    <dbReference type="OMA" id="PSHCKEG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558:SF3">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="378" mass="42815" checksum="87C6332BBE10CDE0" modified="2016-04-13" version="1">MGGCVSRPENCVGGGIKKSSWSKKKRKSRKGLKRRVSSRLYDQPNSVNPTSHGSTDELWYDSATILESDSDGSEGVSWPNIEVHRSSVHPEDMAFQSRCDTSFEKRSLSSSPSTTRKKAAHKLSFKWKNGHPNATTVSSKMHIQRPIAGSQVPFCPIEKKMLDSWSYIEPQTFRVRGKNYLRDKKKEHASNYAAYYPFGVDVFSSQRKIDHIARFVELPSVGSVSAEVPSILVIPLYPAAFFRGEIDGEGISFVLYFKLSDGYSKELSSQFQDNMRRILDDELERVKGFPVDTLIPCRERLKILGHVVNIDDLQLNAPERKLMHAYNGKPVLSRPQHEFYQGNKPEELPEEILCGVRLNGIDYKNYHMLGLNQEPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC59</accession>
    <name>A0A103YC59_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/Sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001832">
        <property type="protein sequence ID" value="KVI06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC59"/>
    <dbReference type="STRING" id="59895.A0A103YC59"/>
    <dbReference type="Gramene" id="KVI06366">
        <property type="protein sequence ID" value="KVI06366"/>
        <property type="gene ID" value="Ccrd_015279"/>
    </dbReference>
    <dbReference type="OMA" id="YKGVYRV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="244"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="595" mass="63930" checksum="6430671BAAFBF40D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDI0</accession>
    <name>A0A103YDI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_014571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001524">
        <property type="protein sequence ID" value="KVI07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDI0"/>
    <dbReference type="Gramene" id="KVI07088">
        <property type="protein sequence ID" value="KVI07088"/>
        <property type="gene ID" value="Ccrd_014571"/>
    </dbReference>
    <dbReference type="OMA" id="KSRCIGY"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000431">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000731">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF71">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119616" evidence="16">
        <location>
            <begin position="27"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="339"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="632" mass="69619" checksum="6B1A5BDCC18639BD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDQ2</accession>
    <name>A0A103YDQ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001509">
        <property type="protein sequence ID" value="KVI07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDQ2"/>
    <dbReference type="STRING" id="59895.A0A103YDQ2"/>
    <dbReference type="Gramene" id="KVI07214">
        <property type="protein sequence ID" value="KVI07214"/>
        <property type="gene ID" value="Ccrd_014404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF283">
        <property type="entry name" value="WRKY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="27096" checksum="A38E8A69EDC991D7" modified="2016-04-13" version="1" fragment="single">MDASLPPTSLPPSQDLNSSSSSSLNFPFSSFNDDPIYRLFDFDHTLYYIHNPNPNPNPNPPLFIDLPSYQDSSSSSFPAYVSMKEQSSVLLDLTTANNTAESSHISIDDTCMPQPDSFHRHVSWVSYFNRLFVAKCRDEFNRERVPDETKISFRVKTALEVLDDGYRWRKYGKKKVKSSPNLRINRNYYKCSSTGCEVKKRVERDKDDSSYLIATYIGMHNHEIPSLIPCNTRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDU3</accession>
    <name>A0A103YDU3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDU3"/>
    <dbReference type="STRING" id="59895.A0A103YDU3"/>
    <dbReference type="Gramene" id="KVI07270">
        <property type="protein sequence ID" value="KVI07270"/>
        <property type="gene ID" value="Ccrd_014288"/>
    </dbReference>
    <dbReference type="OMA" id="FNKYVKC"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055566">
        <property type="entry name" value="ARM_LIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056514">
        <property type="entry name" value="ARM_LIN_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052858">
        <property type="entry name" value="E3_ubiquitin-ligase_LIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056512">
        <property type="entry name" value="LIN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47446">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47446:SF3">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23568">
        <property type="entry name" value="ARM_LIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23654">
        <property type="entry name" value="ARM_LIN_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23628">
        <property type="entry name" value="ARM_LIN_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="9">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1268" mass="141615" checksum="B74BB0A06E596335" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEB3</accession>
    <name>A0A103YEB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-Hand 1, calcium-binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEB3"/>
    <dbReference type="STRING" id="59895.A0A103YEB3"/>
    <dbReference type="Gramene" id="KVI07525">
        <property type="protein sequence ID" value="KVI07525"/>
        <property type="gene ID" value="Ccrd_014060"/>
    </dbReference>
    <dbReference type="OMA" id="WFQADID"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000055">
        <property type="entry name" value="Putative calcium-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF31">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="48680" checksum="FBD1BF470EEAE9D0" modified="2016-04-13" version="1">MGRNHRGIAKRRALRVMGNYAISSSIGDPTCFSCTTFNILAPIYKRLIHEGRACKESDIRSYWLNRNERILDFLLCERSSIICLQEFWVANEELVEMYDTRLGDAGYINFKLPRTNGRGDGLLIAVHKDYFRVIDHRDFLFNDFGDRVAQLLHVELVTPFPQSRSKNVCRELLIVNTHLLFPHDSSMCLERLRQVYKILQFVDAYQKENNLNPLPIVLCGDWNGSKRGHVYKFLRSQGFVSSYDTAHHYTDADAHKWVSHRNHRGNICGVDFIWLLDPNKYRKVLRSSWSDAVFGLFKYLVSRASLTGEDAFAFLKAVSDGDYITYLGFCEALRQLNLIGHRYGLSEDETQDLWVQADIDGNGVLDYKEFQDQEDIANGTQQTTGLSVKNAVMFPTEAENGLWPEEYSLSDHACLRVEFSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFK7</accession>
    <name>A0A103YFK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase A22B, signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_013450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001219">
        <property type="protein sequence ID" value="KVI08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFK7"/>
    <dbReference type="Gramene" id="KVI08181">
        <property type="protein sequence ID" value="KVI08181"/>
        <property type="gene ID" value="Ccrd_013450"/>
    </dbReference>
    <dbReference type="OMA" id="CNNPYLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000007">
        <property type="entry name" value="Signal peptide peptidase-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF90">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="184"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="636" mass="69976" checksum="A89174D9C92AE88C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFM0</accession>
    <name>A0A103YFM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine cleavage H-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001196">
        <property type="protein sequence ID" value="KVI08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFM0"/>
    <dbReference type="STRING" id="59895.A0A103YFM0"/>
    <dbReference type="Gramene" id="KVI08210">
        <property type="protein sequence ID" value="KVI08210"/>
        <property type="gene ID" value="Ccrd_013420"/>
    </dbReference>
    <dbReference type="OMA" id="FWVSKVA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="9994" checksum="4B4E6C6F43475AB8" modified="2016-04-13" version="1">MASRFWVSKVASYLKNLTFNRSFASAGNSAIIGITDHGQDHLRDMVSVELSEVGATVTQGSSFGAVKSVMSTSDINSPVSGKVIGVNKDLTTIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGL2</accession>
    <name>A0A103YGL2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01001098">
        <property type="protein sequence ID" value="KVI08680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGL2"/>
    <dbReference type="Gramene" id="KVI08680">
        <property type="protein sequence ID" value="KVI08680"/>
        <property type="gene ID" value="Ccrd_012948"/>
    </dbReference>
    <dbReference type="OMA" id="VIPCASM"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000027">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF322">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119704" description="Hexosyltransferase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI08680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="32201" checksum="C2524BE3060D1D0F" modified="2016-04-13" version="1">MLPSMAAAILIVIFNLGVKTPYLLSSNIQNYPSTKQFSLLIGILTRADNYDRRHFLRLIYGIQSSPLAEVDVKFVFCNLTKQEQRVLIALEILRFNDIIILNCSENMNNGKTYTYFSSLPRILSRTYNYVMKADDDVFLRLLPLTSSLQPLPRSDCYYGFVIPCQSMNPFVSYMSGMGYILSWDLVEWIANSDIPRNNTYGPEDKLVGRWLDLGQKARNRFSNKPAMYDYPGKNGRCSHELIPDTIAVHRVKRWDQWFAVINYFNVTKELRPSKLYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHT9</accession>
    <name>A0A103YHT9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperone, tailless complex polypeptide 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHT9"/>
    <dbReference type="STRING" id="59895.A0A103YHT9"/>
    <dbReference type="Gramene" id="KVI09322">
        <property type="protein sequence ID" value="KVI09322"/>
        <property type="gene ID" value="Ccrd_012294"/>
    </dbReference>
    <dbReference type="OMA" id="LVLICHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="61381" checksum="527E2380D1C2BA43" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIV1</accession>
    <name>A0A103YIV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YIV1"/>
    <dbReference type="Gramene" id="KVI09897">
        <property type="protein sequence ID" value="KVI09897"/>
        <property type="gene ID" value="Ccrd_011717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="125" mass="14214" checksum="79C72FAE0C02A835" modified="2016-04-13" version="1" fragment="single">NPPDTQLSLVQRFDPREIPSLSAEAQELVRTLLKNLNYEXPLLSTLNKSDKWLQCLEIPSTYELLYKSYTKANMKELLQKLMKHIDRDGIVPNKRLFLDALGALGSSYGNSIPTKVNLRMPADIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL64</accession>
    <name>A0A103YL64_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000933">
        <property type="protein sequence ID" value="KVI11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL64"/>
    <dbReference type="STRING" id="59895.A0A103YL64"/>
    <dbReference type="Gramene" id="KVI11065">
        <property type="protein sequence ID" value="KVI11065"/>
        <property type="gene ID" value="Ccrd_010529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF18">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="803" mass="91567" checksum="85F4B09A8DA95704" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM24</accession>
    <name>A0A103YM24_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000060">
        <property type="protein sequence ID" value="KVI11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM24"/>
    <dbReference type="STRING" id="59895.A0A103YM24"/>
    <dbReference type="Gramene" id="KVI11666">
        <property type="protein sequence ID" value="KVI11666"/>
        <property type="gene ID" value="Ccrd_009926"/>
    </dbReference>
    <dbReference type="OMA" id="KPSACWP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33416">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33416:SF18">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="732" mass="79233" checksum="331249BB45CB6C0A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM99</accession>
    <name>A0A103YM99_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Multi antimicrobial extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000043">
        <property type="protein sequence ID" value="KVI11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM99"/>
    <dbReference type="STRING" id="59895.A0A103YM99"/>
    <dbReference type="Gramene" id="KVI11786">
        <property type="protein sequence ID" value="KVI11786"/>
        <property type="gene ID" value="Ccrd_009800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45554" checksum="C7FA6D4EF734E8C3" modified="2016-04-13" version="1">MEEEGLGTPFVGQESEKRIISYSKDEILGEFKKQVYLAGPLMTVNLLICGLSMISVMFVGHLGELALSGASMATSFASVTGTSLMIGMGSALDTFCGQSYGAKRYHLLGIHMQRAMIVLLSVSIPLAFIWAYAGYLLVFLGQDPQISAEAGLYARFMIPSLFANALLQCFVRFLQAQNNVVPMMLSTGITTLLHILVCWIMVFKSGLGNRGAALANAISLWINVLLLAVYVRVSPSLEIWSFEMMVLLSGLLPNPQLETSVLSISLNTCSMIYMIPLGLSSATRSLTMKKGSTSSGNFASKTVGTIGIISADPVETTVTFNGGKGVGSFETKSRVSYGDKQSGCYGRKTTKEKASAGEFQWKNGTSGTKSEYKKSSTVRVGNKSGYTEIYSEQRVRDVSYNKSKYLIEYDNGDNGYVSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMX7</accession>
    <name>A0A103YMX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late embryogenesis abundant protein, LEA-25/LEA-D113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LEA type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000019">
        <property type="protein sequence ID" value="KVI12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMX7"/>
    <dbReference type="STRING" id="59895.A0A103YMX7"/>
    <dbReference type="Gramene" id="KVI12044">
        <property type="protein sequence ID" value="KVI12044"/>
        <property type="gene ID" value="Ccrd_009541"/>
    </dbReference>
    <dbReference type="OMA" id="GHQDPNT"/>
    <dbReference type="OrthoDB" id="758082at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005513">
        <property type="entry name" value="LEA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33493:SF2">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33493">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03760">
        <property type="entry name" value="LEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13170" checksum="40046D3146AF54D3" modified="2016-04-13" version="1">MQAVKETAANIAASAVSGLDKTLAVIDEKVEKISTSDPVEKDMATLRKEDRIRMAELRKQQAYSQNAAAAFGGGAPGSPTYTAAGSGHPEKNPFHITKADVSNANKPAEQTTTVQSAMPATAQPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNA5</accession>
    <name>A0A103YNA5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_009379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNA5"/>
    <dbReference type="STRING" id="59895.A0A103YNA5"/>
    <dbReference type="Gramene" id="KVI12234">
        <property type="protein sequence ID" value="KVI12234"/>
        <property type="gene ID" value="Ccrd_009379"/>
    </dbReference>
    <dbReference type="OMA" id="RINWASK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000256">
        <property type="entry name" value="oligouridylate-binding protein 1-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF27">
        <property type="entry name" value="OS07G0615400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="39225" checksum="885B40598B9B3E89" modified="2016-04-13" version="1">MIQQQQQQRIRQQQALMQQSLYHPGLLAHPQIEPILSGNLPPGFDSTTCRSVYVGNIHPQVTEPLLQEIFSSTGALEGCKLIRKEKSSYGFVDYFDRRFAALAIVTLNGRHLFGQPIKVNWAYASHFNIFVGDLSPEVTDATLFACFSAYPTCSDARVMWDQKTGRSRGFGFVSFRNQQDAQSAINDLNGKWLGSRQIRCNWAAKGAGSDDKQRSDAKSVVELTNGTSDDGQEKTNEDAPENNPQYTTVYVGNLAPEVTSGDLHCHFHALGAGVIEDCSWGSKPTPPGSSSTPLPLPMTGNMLGFSATDLAAYERQLALSKMGGLQALMHQQMGAAASQGAIYDGGYPGIAATQAPMYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNC3</accession>
    <name>A0A103YNC3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM192 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YNC3"/>
    <dbReference type="Gramene" id="KVI12205">
        <property type="protein sequence ID" value="KVI12205"/>
        <property type="gene ID" value="Ccrd_009366"/>
    </dbReference>
    <dbReference type="OMA" id="LYIWCIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029399">
        <property type="entry name" value="TMEM192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="32296" checksum="C6C79C367B69B5AB" modified="2016-04-13" version="1">MSSDRHAASRXASPDDNYLFLDISNEAPLYGQRKHTSIIGSILYCLLLASYATLAVGAPWVFQSKQYLILKLLSTCDVALLIITGLLYFQSKDEAYYSPTLCQYVIWHRGDATYHGLGAIYKNSSNSYDSQGLFNDMEGLFALPYLSVCLWLNDXAISNFAYGFSPSSRLFYWIIMVVEAIFAASFMSIYIGNVHQYNTLESQPDVLKSLYSPLQPPSSLEALRLQECLSKFERSGDGTAPQVDLAHLLAARDQELRTLSAEVIRMSRSIFIPSPYQVNAYESLGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118EDK4</accession>
    <name>A0A118EDK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01010283">
        <property type="protein sequence ID" value="KVE66068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118EDK4"/>
    <dbReference type="STRING" id="59895.A0A118EDK4"/>
    <dbReference type="Gramene" id="KVE66068">
        <property type="protein sequence ID" value="KVE66068"/>
        <property type="gene ID" value="Ccrd_023929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVE66068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="81" mass="8805" checksum="27EE9108AEC3D126" modified="2016-04-13" version="1">MPVIVGRGICANENSDMTLEHIVEVTGLSPKATEQDVYTFFAFCGTIEHVDIVRHAAGSDRLFALASPKGLRSQKTMKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSK5</accession>
    <name>A0A118JSK5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005355">
        <property type="protein sequence ID" value="KVH88657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSK5"/>
    <dbReference type="STRING" id="59895.A0A118JSK5"/>
    <dbReference type="Gramene" id="KVH88657">
        <property type="protein sequence ID" value="KVH88657"/>
        <property type="gene ID" value="Ccrd_026212"/>
    </dbReference>
    <dbReference type="OMA" id="FINDERG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF475">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING DOMAIN, PGG DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="2">
        <location>
            <begin position="602"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="789" mass="89256" checksum="731BBD2F19469CB9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTB7</accession>
    <name>A0A118JTB7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA-processing protein, HAT helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTB7"/>
    <dbReference type="STRING" id="59895.A0A118JTB7"/>
    <dbReference type="Gramene" id="KVH90057">
        <property type="protein sequence ID" value="KVH90057"/>
        <property type="gene ID" value="Ccrd_007989"/>
    </dbReference>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="78"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="326"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="712" mass="85500" checksum="DCB24A53E4060858" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTZ5</accession>
    <name>A0A118JTZ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTZ5"/>
    <dbReference type="STRING" id="59895.A0A118JTZ5"/>
    <dbReference type="Gramene" id="KVH91584">
        <property type="protein sequence ID" value="KVH91584"/>
        <property type="gene ID" value="Ccrd_006402"/>
    </dbReference>
    <dbReference type="OMA" id="CACKQAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="793" mass="87605" checksum="7946815309256BE5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUV4</accession>
    <name>A0A118JUV4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005796</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004840">
        <property type="protein sequence ID" value="KVH92171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUV4"/>
    <dbReference type="STRING" id="59895.A0A118JUV4"/>
    <dbReference type="Gramene" id="KVH92171">
        <property type="protein sequence ID" value="KVH92171"/>
        <property type="gene ID" value="Ccrd_005796"/>
    </dbReference>
    <dbReference type="OMA" id="HSMIANQ"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000009">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15058" checksum="415B189EA33F591E" modified="2016-04-13" version="1">MSSKSDADAKKGGRGKPKSTKSVSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKKTRIIPRHIQLAVRNDEELSRLLGSVTIANGGVLPNINQTLLPKKVGKDKGEIGSASQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY06</accession>
    <name>A0A118JY06_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein cS22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">30S ribosomal protein 2, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_000830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the chloroplast small ribosomal subunit (SSU). Mature 70S chloroplast ribosomes of higher plants consist of a small (30S) and a large (50S) subunit. The 30S small subunit contains 1 molecule of ribosomal RNA (16S rRNA) and 24 different proteins. The 50S large subunit contains 3 rRNA molecules (23S, 5S and 4.5S rRNA) and 33 different proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloroplast-specific ribosomal protein cS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003865">
        <property type="protein sequence ID" value="KVH97072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY06"/>
    <dbReference type="STRING" id="59895.A0A118JY06"/>
    <dbReference type="Gramene" id="KVH97072">
        <property type="protein sequence ID" value="KVH97072"/>
        <property type="gene ID" value="Ccrd_000830"/>
    </dbReference>
    <dbReference type="OMA" id="DYAPERN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21609">
        <property type="entry name" value="RRM1_PSRP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000401">
        <property type="entry name" value="30S ribosomal protein 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN CS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH97072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="27464" checksum="722DBEC6A35335DF" modified="2016-04-13" version="1">MATISSSIISSTSYLHHHSTSKSFKIQQPKFTPTLSQTSLRFTISNPRHPTRLLSVAEEAPATAVTYDPSSEAARRLYVGNIPRTTNNDELHKVFEEHGAIEKVEVMYDKYSGRSRRFGFVTMKTVDDANAAIEKLNGTEIGGRKIKVNVTEKPLNGVGFSVLQAEETPFVDSPYKLYVGNLAKTVTSDSLKTFFSEKGNVVGAKVSRVPGTSKSSGFGFVSFSSEEEVEVAISSFNDAVLEGQKIRVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY31</accession>
    <name>A0A118JY31_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY31"/>
    <dbReference type="STRING" id="59895.A0A118JY31"/>
    <dbReference type="Gramene" id="KVH97914">
        <property type="protein sequence ID" value="KVH97914"/>
        <property type="gene ID" value="Ccrd_023877"/>
    </dbReference>
    <dbReference type="OMA" id="YMQGVLT"/>
    <dbReference type="OrthoDB" id="773154at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049172">
        <property type="entry name" value="DUF6857_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048297">
        <property type="entry name" value="DUF936_dom_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010341">
        <property type="entry name" value="DUF936_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21647">
        <property type="entry name" value="DUF6857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06075">
        <property type="entry name" value="DUF936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF936" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="340"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="56679" checksum="CD96E7709C791325" modified="2016-04-13" version="1" fragment="single">MASLTPGFLLKLLRTINSNIKVRGEYRSILLQVISIVPALNGSELWPNHGFFIKISDSSHSTYASLSKEDNELILNNKLQLGQFFWVDRMDVGTPVPVLVGVRPVPGRHPFIGNPKDLMQMLEPSEAIKSSEMVEAKEESTKKKIVIKEEKVTVASRYMQGAVAKNDGLKKDENESNSRNGTIKGRQQETKGQAHTTTSLHKLSDALRPRVGAGVNGRFTEPLTIKQENVNSNLVQRRRDKNHSSETVSWSSLPPRLLNPAKGMIRRRTLASLAAAEAQKEAITAANLVKCLRIFGQLCSSASHANPHESLTKFFSLYGLIEEENVSVIPKEDKLLEFSSSSQEPDKLNKSSKKTGVARVTSTKKTPKTWVELTVAEKLEWARGDGMKEGKEVREILLDVTQSWFLEFLERALDVGFQMGNLETVKGKGKNHNNIANKTEPSSQIAVTLSQLKQANEWLDKLRSKMMLEEKQEMLVETIDGLKQKIYACLLVHVDSAAVALENRCDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYJ0</accession>
    <name>A0A118JYJ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003825">
        <property type="protein sequence ID" value="KVH97539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYJ0"/>
    <dbReference type="Gramene" id="KVH97539">
        <property type="protein sequence ID" value="KVH97539"/>
        <property type="gene ID" value="Ccrd_000350"/>
    </dbReference>
    <dbReference type="OMA" id="EKGFDKC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF21">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="608" mass="69151" checksum="9A8E9609C41C2DD5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYQ2</accession>
    <name>A0A118JYQ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003818">
        <property type="protein sequence ID" value="KVH97809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYQ2"/>
    <dbReference type="STRING" id="59895.A0A118JYQ2"/>
    <dbReference type="Gramene" id="KVH97809">
        <property type="protein sequence ID" value="KVH97809"/>
        <property type="gene ID" value="Ccrd_000068"/>
    </dbReference>
    <dbReference type="OMA" id="TFWAWNL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000198">
        <property type="entry name" value="High affinity nitrate transporter 2.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000053">
        <property type="entry name" value="Nitrate transporter 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="389" mass="42354" checksum="643AC4F129CA194F" modified="2016-04-13" version="1">MDISQNLEKNDRKFALPVDSEHKATEFRLFSMATPHMRAFHLSWISFFSCFVSTFAAPPLLPIIRDNLDLTATDIGNAGIAAVSGAVFARIAMGTACDLFGPRLASSSLILLTAPAVFLSAIANSPAAFLMVRFFTGFSLATFVSTQFWMSSMFSPAVVGTANGLSGGWGNLGGGATQLIMPLVYSLIHSHIGSTKFTAWRIAFFIPAVFQTLSAFAIFFLGQDMPDGNYVRLEKSGEKHKDNFSQVFYHAITNYRGWILALTYGYCFGVELTIDNIIAQYFYDRFNVNLHTAGIIAASFGLANLFSRPGGGILSDVVAKRFGMRGRLWTLWVVQMIGGFLCLLLGKVGSLTASIVVMLVFSVFVQAACGLTFGVVPFVSRRYVLSPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYR6</accession>
    <name>A0A118JYR6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Histidine kinase-like ATPase, ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_022763</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MORC ATPase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYR6"/>
    <dbReference type="Gramene" id="KVH98977">
        <property type="protein sequence ID" value="KVH98977"/>
        <property type="gene ID" value="Ccrd_022763"/>
    </dbReference>
    <dbReference type="OMA" id="WNTNCHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000075">
        <property type="entry name" value="MORC family CW-type zinc finger protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF60">
        <property type="entry name" value="HISTIDINE KINASE_HSP90-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Morc S5" evidence="16">
        <location>
            <begin position="367"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="522"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="666"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="763" mass="85593" checksum="33C20321A7AAF2DE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZP6</accession>
    <name>A0A118JZP6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003461">
        <property type="protein sequence ID" value="KVH99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZP6"/>
    <dbReference type="STRING" id="59895.A0A118JZP6"/>
    <dbReference type="Gramene" id="KVH99519">
        <property type="protein sequence ID" value="KVH99519"/>
        <property type="gene ID" value="Ccrd_022246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23520" checksum="F84F7E743A3EAE16" modified="2016-04-13" version="1" fragment="single">IINSPTTDGRQYNLPSAIEVAGLIVGDLSENNFERDVIVEHRTTGLQRITDLHPSFMSMTYPLIHPYGEDGFRENILLQNMDGSSSKRQLVTMRQYYCFHLQQRSNEGHTFLRAALSEDMATLQRKKYKAHDMQQTDDQIEAHTLFKIEAIMLKMGKSLIYGMSLPNTELLRKFRNRLVNEELDYCTQDLKVAHEIAFSSLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K042</accession>
    <name>A0A118K042_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003185">
        <property type="protein sequence ID" value="KVI00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI00887">
        <property type="protein sequence ID" value="KVI00887"/>
        <property type="gene ID" value="Ccrd_020853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="12614" checksum="316619485FF1380E" modified="2016-04-13" version="1">MDAGDFSKLIDSEGAKASLAFPSGFTEAYSIPSRAQMVLKHGGRKFDVIVEDGYLTRGWSYFVGEHDIQYGYAXKFHFVGCSTYEIEIFDRKRSKRVYPWSNLEYHEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0F2</accession>
    <name>A0A118K0F2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003370">
        <property type="protein sequence ID" value="KVI00600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0F2"/>
    <dbReference type="STRING" id="59895.A0A118K0F2"/>
    <dbReference type="Gramene" id="KVI00600">
        <property type="protein sequence ID" value="KVI00600"/>
        <property type="gene ID" value="Ccrd_021158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="19921" checksum="F96A0120D1ED3740" modified="2016-04-13" version="1">MMHQGWSDNLLNLIGGEEHLKVWDKGSGQVALDSGALAIAEHEGKILYTDADKILLSGSQAIQCKDPLKNTCDWLGRMEKQRRSSGNVTALQTAVLTANNAIAAPDYLVTVDVRTNNFEGEFNRSLRIDSEMLIVQMNSVYLLVLPQFKSTEEVARVWFVEIVKMHESEFGGRDQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K160</accession>
    <name>A0A118K160_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-synthase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002671">
        <property type="protein sequence ID" value="KVI01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K160"/>
    <dbReference type="STRING" id="59895.A0A118K160"/>
    <dbReference type="Gramene" id="KVI01936">
        <property type="protein sequence ID" value="KVI01936"/>
        <property type="gene ID" value="Ccrd_019785"/>
    </dbReference>
    <dbReference type="OMA" id="RRTENDM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051776">
        <property type="term" value="P:detection of redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF20">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="27583" checksum="35C2F665B89AFCBC" modified="2016-04-13" version="1">MSFVMDSIILPAACISAVVSASQLRRLRCTSSHSSGLRGRKLSVTDSSLRFSNRDHSWSPAVHSVAADTTNSTPPRDGIYTVGDFMTRKADLLVVEETTPVDKGMHGLGVLLALEILVEKRITGFPVIDADWNLVGVVSDYDLLALDSISGGSHGDTSLFPDVDSSWKTFNEIQKLVGKTDGKVVGDLMTPAPLVVHETTNLEEAVRLLLETKYRRLPVVDVDGKLVGLITRGDVVRAALRIKDAIKKMQLSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K169</accession>
    <name>A0A118K169_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxypeptidase</fullName>
            <ecNumber evidence="8">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K169"/>
    <dbReference type="Gramene" id="KVI01981">
        <property type="protein sequence ID" value="KVI01981"/>
        <property type="gene ID" value="Ccrd_019766"/>
    </dbReference>
    <dbReference type="OMA" id="CHAGEAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000409">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF460">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990284" description="Carboxypeptidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="44056" checksum="EC79417A4153B015" modified="2016-04-13" version="1">MKTAFLFSVHFSLLVFVHCYGGNGYDPLETALNIQRSKRSQSAYHVSNQDSRADQNSYSPVYVGSQDGLKDFDKISALPGEPAGTDFDQYSGYVTVEPNHGRALFYYFTESPSNSSTNPLVLWLNGVANVLFLESPAGVGFSYSNTSSDYITGDIQTAKDSYTFLVNWLERFPEYKTRDFYITGESYAGHYVPELAQLILQNNKITNQTVINLKGIALGNAYVDDETENTGMFDYFWTHAIISDEIHEGIVSNCNFSEAAPSTAVCHNYVQQAYAAKSNIYFYDIYAPLCSSSSNSTPSISGFDPCTEYYILAYLNTPAVQQSLHARPVQWESCNDFILEHWQDMPFTVLPVGGYVVGYENLTFVTIRGAGHFVPSYQPARGLAFFSSFLEGKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1M3</accession>
    <name>A0A118K1M3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002535">
        <property type="protein sequence ID" value="KVI03118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1M3"/>
    <dbReference type="STRING" id="59895.A0A118K1M3"/>
    <dbReference type="Gramene" id="KVI03118">
        <property type="protein sequence ID" value="KVI03118"/>
        <property type="gene ID" value="Ccrd_018589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7810" checksum="CD6980F10FF78838" modified="2016-04-13" version="1">MAHLQHAVVMVLSTYRKGITKRGCIRWMRFREVSSRLESHELDAIFVRSVNEVEVKPKPKVYPNLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2I8</accession>
    <name>A0A118K2I8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002094">
        <property type="protein sequence ID" value="KVI04423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K2I8"/>
    <dbReference type="Gramene" id="KVI04423">
        <property type="protein sequence ID" value="KVI04423"/>
        <property type="gene ID" value="Ccrd_017263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF34">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="82" mass="9087" checksum="4B1B8B4A5F35AC36" modified="2016-04-13" version="1">MITGCLLILEELFAQTKYKEAVELVAESPQGILXTPDTHAKFXSVPVQAEQTPPLLQHFGILLTKRKLNAFESLKLSCLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3Y4</accession>
    <name>A0A118K3Y4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZCF37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001739">
        <property type="protein sequence ID" value="KVI06708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3Y4"/>
    <dbReference type="STRING" id="59895.A0A118K3Y4"/>
    <dbReference type="Gramene" id="KVI06708">
        <property type="protein sequence ID" value="KVI06708"/>
        <property type="gene ID" value="Ccrd_014937"/>
    </dbReference>
    <dbReference type="OMA" id="QDEHRII"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045880">
        <property type="entry name" value="ZCF37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35275">
        <property type="entry name" value="ZCF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35275:SF10">
        <property type="entry name" value="ZCF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27246" checksum="98237131FA029733" modified="2016-04-13" version="1">MAFICGSFHRQDQEDAYEVLWPFPSTSPKRRHVFSCRTSKNSTNPYADRGLDKFEALLSDLDHKRQKILTQKGSEDVSMVKFVYRSPHEEVTPIVIKLRHQRKHNKTSLSQTQEPKQHQKDVAFAPDKYGGNGIDEGKRGKPALVDGKSKMIKKIKCDEWGRKVREWWKPSCYLALFVILILVLLMFLGRSFAILCTSLGWYLVPIINETLHVQSSRRRSRSKSNEKANNKQTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4J0</accession>
    <name>A0A118K4J0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4J0"/>
    <dbReference type="STRING" id="59895.A0A118K4J0"/>
    <dbReference type="Gramene" id="KVI07618">
        <property type="protein sequence ID" value="KVI07618"/>
        <property type="gene ID" value="Ccrd_014039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="84" mass="9462" checksum="D8554847D5B7AC5B" modified="2016-04-13" version="1" fragment="single">MIEEANTSWHNDKWKPRGNGSDDDDDEDDEDDDAAQDKARAFDDWKDDNPQGAGNKKLIPCALSEIDLIFTHMEDPGANQVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6R0</accession>
    <name>A0A118K6R0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000935">
        <property type="protein sequence ID" value="KVI11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6R0"/>
    <dbReference type="STRING" id="59895.A0A118K6R0"/>
    <dbReference type="Gramene" id="KVI11058">
        <property type="protein sequence ID" value="KVI11058"/>
        <property type="gene ID" value="Ccrd_010538"/>
    </dbReference>
    <dbReference type="OMA" id="SGVKYMN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47809">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47809:SF2">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="502" mass="54990" checksum="A0EE396340F9D12A" modified="2016-04-13" version="1">MKRKRGKKGKSKKAPKVGITETDPNIVNLSAEDVSGPDDVEKDETNSRMDIETPSSTGTDQPEKPAAVSSTGAIDKPVGRLVYNRVKVKIKPSKALETQLTSSDAHTHSDTDKSSQQIGLEKQVVSDKVEDSANSVPDSNVGVSATHAKKAGSIKIKSSKDFTSSLSPCNNAGVAQAERSHQKEPESLSRDSVYNKQELHASLEVVKKIMKMDAAEPFNVPVNPVALGIPYDCLSSSQHVIFVAGDVKDGNISSHGKTSKGGHLKHKSRKRHGVKRHKDDCLCAICIMMRRRQEREQIMHPADDQTETSDGLVYEVKTEVMVGSPNGDDTSSSTDNSQNQDADAEMEDKGEEVKLEKEIHNSYQSKQQAEKEKETPCQTNKESAIAEQSQLPGKSGGVQMAEAGDATKDDANNEEQLMQHEDETAVVEHQKPKELADASEKAKLYENLHQRYENPMVLELCASLFPENPKSLWRRPHSLVHHHHHGSSRSNSIGAAISSFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K794</accession>
    <name>A0A118K794_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000025">
        <property type="protein sequence ID" value="KVI11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K794"/>
    <dbReference type="STRING" id="59895.A0A118K794"/>
    <dbReference type="Gramene" id="KVI11893">
        <property type="protein sequence ID" value="KVI11893"/>
        <property type="gene ID" value="Ccrd_009679"/>
    </dbReference>
    <dbReference type="OMA" id="TCYPLDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312:SF132">
        <property type="entry name" value="OS01G0855200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="55318" checksum="2FCFA478BC0E784C" modified="2016-04-13" version="1">MKMKMADRCLNWSQHSIPQSPSSSSSLQTLASAISSPSAKRRSLTHLALAYRYVHRSAIFGTELNRSVSSRKQKPIKSAVTGSLDAEFSDEEFSKKIQELALRLGSESEIQDPFAGLKMEPPEWPGDMIPASIERKANSVELPFSLRIIKRKKQWQEGLREAGGSAYCSVKKAFSSMVFIIRELQSYTLQMRELLYYEDLQEILVRVQKEMNASFVWLFQQVFSQTPTLMVYVMILLANYSVYSISNNVAIAGAPPPATVESMEHHSHTKFDSSSIKTFSAGKTTSIGGNNGGGGKFRAVASGTDGDGRFDGSVTSSSSIVNPTRTSEESVSGQESQKEEWESWNAIVDEADRMQGVIGDGGLDHETMKRFVSPVTVKLVEEDTEDHFRTELLYQTGLSQEPDNPLLLANYAQAEDYFKRATKVEPKDAEALSKYASFLWQIRKDLWAAEETYLEAISADPDNSFYAANYAHFLWSTGGEDTCYPLDSPETGFSDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7C7</accession>
    <name>A0A118K7C7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000017">
        <property type="protein sequence ID" value="KVI12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7C7"/>
    <dbReference type="Gramene" id="KVI12060">
        <property type="protein sequence ID" value="KVI12060"/>
        <property type="gene ID" value="Ccrd_009523"/>
    </dbReference>
    <dbReference type="OMA" id="WLDLWSK"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042977">
        <property type="entry name" value="AtJ6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="285" mass="32808" checksum="9A6E0C5F9F2B7EC6" modified="2016-04-13" version="1">MGKRKKTAIHEENIEEDEQKQQNNRGESSSSSDDKSLYEILGVERTASQQEIKKAYHKLALRLHPDKNPGDEDAKEKFQQLQKVISILGDEEKRALYDQTGCVDDADLAGDVVQNLKDFFRTMYKKVTEADIDEFEANYRGSESEKTDLIDLYKKYKGHMNRLFCSMLCSDPKLDSHRFKDIIDEAISTGEVKSMKAYQKWAKQISETKPPTNPLQRRRKSKKESDDLYAIISQRQSERKGRLDAMFSSLVGKYGGDEPSSEPTEEEFEAAREKLKKRKGCKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7P3</accession>
    <name>A0A118K7P3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein, orthogonal bundle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7P3"/>
    <dbReference type="STRING" id="59895.A0A118K7P3"/>
    <dbReference type="Gramene" id="KVI12540">
        <property type="protein sequence ID" value="KVI12540"/>
        <property type="gene ID" value="Ccrd_009147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043253">
        <property type="term" value="C:chloroplast ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF5">
        <property type="entry name" value="DAR GTPASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="31464" checksum="3678ACFA8EA26B02" modified="2016-04-13" version="1">MAIHLSGVFFNKSSISSPVFQHQRRPPLTVFAAASASASAAHPPSSPPTIQIVGGKSASWYGNGDMNSSNAVDCFKDGYDWADLENDLYHWTKTLRPVQWYPGHIAKTERELKEQLKLMDVVIEMDSWLGNRKRILVLNREDMISTADRNAWADYYGRQGIKVVFSNGKLGMGAMKLGRLAKSVAAERRMCPAAPRPGVTRSLKWVRFGSDLELLDSPGIIPMRMSDQTAAIKLAICDDIGEKSYDVTDVAAVLVQMLSKLPAANNNVLWERYKIDTDGRCGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAW6</accession>
    <name>A0A124SAW6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_025769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005339">
        <property type="protein sequence ID" value="KVH88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAW6"/>
    <dbReference type="STRING" id="59895.A0A124SAW6"/>
    <dbReference type="Gramene" id="KVH88766">
        <property type="protein sequence ID" value="KVH88766"/>
        <property type="gene ID" value="Ccrd_025769"/>
    </dbReference>
    <dbReference type="OMA" id="RGIYQWM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009884">
        <property type="term" value="F:cytokinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071215">
        <property type="term" value="P:cellular response to abscisic acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010087">
        <property type="term" value="P:phloem or xylem histogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010271">
        <property type="term" value="P:regulation of chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048509">
        <property type="term" value="P:regulation of meristem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010029">
        <property type="term" value="P:regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080117">
        <property type="term" value="P:secondary growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000137">
        <property type="entry name" value="Histidine kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000015">
        <property type="entry name" value="Histidine kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.350:FF:000001">
        <property type="entry name" value="Histidine kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="entry name" value="CHASE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056839">
        <property type="entry name" value="Receiver_AHK4/CRE1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF51">
        <property type="entry name" value="HISTIDINE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24896">
        <property type="entry name" value="Receiver_CRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="14">
        <location>
            <begin position="103"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="813"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="958" mass="105759" checksum="980CFEE43062C835" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCD0</accession>
    <name>A0A124SCD0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14, caspase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004771">
        <property type="protein sequence ID" value="KVH93412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCD0"/>
    <dbReference type="STRING" id="59895.A0A124SCD0"/>
    <dbReference type="Gramene" id="KVH93412">
        <property type="protein sequence ID" value="KVH93412"/>
        <property type="gene ID" value="Ccrd_004536"/>
    </dbReference>
    <dbReference type="OMA" id="CEDYETA"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF17">
        <property type="entry name" value="METACASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="43726" checksum="ECEC039EA825C31D" modified="2016-04-13" version="1">METQGRCKGCKNYLMVPPGRPCPVCYKVSKPNKKASHHVIPQVLHYVDKYANRASSNNYYNGLYGQPLGTPTYTGYSAPPPQAAYGYGYYSPQPQALSSPALYSNGYDRPKPQMYQQSPQVHEKKRAVLCGVTYKGHIKALDASINNVRSMHRLLVKLGFPNASIRILTEEESEPTRTPTRRNILMALEWLTKGCRAGDSLVFYYAGHGSHVPDSNGDEKDGFDEALCPVDYSESGKILDDEINAIIVAPLPHGAILHSIMDTCFSGTLLDLPFLCRIDRGGFYKWEDHHPSYVSSYGGTSGGKAICISACDDHQNSADTSAFTGNSIGALTYSFIQAVQSSRKLSYGDLLDNMRKRVHDAHQRQGLNASFASSSSQEPQLSCSTRFEIYSEAFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCG1</accession>
    <name>A0A124SCG1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004636">
        <property type="protein sequence ID" value="KVH93671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCG1"/>
    <dbReference type="Gramene" id="KVH93671">
        <property type="protein sequence ID" value="KVH93671"/>
        <property type="gene ID" value="Ccrd_004274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="11312" checksum="0CBE02D0AE734D13" modified="2016-04-13" version="1">MSSIISSGHILQSIASIDKKRLTKVIAKRNKRHRKFYARRLQLLTDLYAFSVQHKNISEVKTNYNENRRQGENSRYHRSVIFLPQYPYAKVNFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCU2</accession>
    <name>A0A124SCU2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_003070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004514">
        <property type="protein sequence ID" value="KVH94852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCU2"/>
    <dbReference type="STRING" id="59895.A0A124SCU2"/>
    <dbReference type="Gramene" id="KVH94852">
        <property type="protein sequence ID" value="KVH94852"/>
        <property type="gene ID" value="Ccrd_003070"/>
    </dbReference>
    <dbReference type="OMA" id="GAMMINE"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF2">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176158" evidence="11">
        <location>
            <begin position="27"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="305"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH94852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="768" mass="84008" checksum="5B016D02D6D9B05E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDJ1</accession>
    <name>A0A124SDJ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003861">
        <property type="protein sequence ID" value="KVH97092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDJ1"/>
    <dbReference type="STRING" id="59895.A0A124SDJ1"/>
    <dbReference type="Gramene" id="KVH97092">
        <property type="protein sequence ID" value="KVH97092"/>
        <property type="gene ID" value="Ccrd_000810"/>
    </dbReference>
    <dbReference type="OMA" id="MQRYEVF"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000055">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF25">
        <property type="entry name" value="TAFII28-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="9">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="23863" checksum="7A34E3BB139ECB9A" modified="2016-04-13" version="1">MKQSKDPFEVAFEELDESPPDSPNPHDEIETQTLAAKPSKNSQRYDVEHSTSPSNQPKARVRFSSTSAAIPTNKNKEDDDEEEEENMDVELGKFASTGDPDKMAKMQSILSQFTEEQMSRYESFRRSGFQKSNMKRLLGSITGSSKISMPMTIVVSGIAKIFVGELVETAKMVMTERKESGPIRPCHVREAYRRLKLEGKIPKRSVPRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEW3</accession>
    <name>A0A124SEW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003119">
        <property type="protein sequence ID" value="KVI01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEW3"/>
    <dbReference type="Gramene" id="KVI01333">
        <property type="protein sequence ID" value="KVI01333"/>
        <property type="gene ID" value="Ccrd_020399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="107" mass="12395" checksum="E00FB31451F07F8B" modified="2016-04-13" version="1">MRWCQVGFSALNMLSKYLFNLISQWLKHWTIRLRPKCPSRGICTRTDSVTMSGHSSSRMLYSSMMKARKMLAELRSWHATPSCWSNKHPSDHGYEIHPSLVSLPVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF02</accession>
    <name>A0A124SF02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acid phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01002747">
        <property type="protein sequence ID" value="KVI01696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF02"/>
    <dbReference type="STRING" id="59895.A0A124SF02"/>
    <dbReference type="Gramene" id="KVI01696">
        <property type="protein sequence ID" value="KVI01696"/>
        <property type="gene ID" value="Ccrd_020024"/>
    </dbReference>
    <dbReference type="OMA" id="YTSNHIH"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.380:FF:000001">
        <property type="entry name" value="Fe(3+)-Zn(2+) purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF144">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15451" checksum="ADC49C9FAE690DB2" modified="2016-04-13" version="1">MPFDSDVFSLPSGYNAPQQVHITQGAHVGRSVIVSWVTQNEPGSETVVYWAESSHRKHNATAMVTTYKYYNYTSGFIHHCTIKHLKFDTKYYYEIETSPTVRRFWFMTPPAVGLINKLCSHHLPYAATIGSFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHT9</accession>
    <name>A0A124SHT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_010988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001010">
        <property type="protein sequence ID" value="KVI10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHT9"/>
    <dbReference type="STRING" id="59895.A0A124SHT9"/>
    <dbReference type="Gramene" id="KVI10603">
        <property type="protein sequence ID" value="KVI10603"/>
        <property type="gene ID" value="Ccrd_010988"/>
    </dbReference>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="292" mass="32187" checksum="C5635FD85B033F90" modified="2016-04-13" version="1">MLTVSDGGRANFTCISAQQPGLKDEDDTPRNNLKKALDSAPPSRDFRGVLKEIMKENNSIFSLKKALDNAPPSRDFRGALKVSYIRTGSPGLIAEVKKASPSRGVLREDFHAVEIAKAYESGGAACLSVLTDEEYFQGSFENLEDIRNSGVKEPLTLVKMQCPLLCKDFIVDVVQLYYARIKGADAVLLIAAILPDIDIKRMLKICKKIGLAALVEVHDENEMDRMLGIDGIELLGINNRDLETFEVDISITKKLLEGERGEKIQQKGIISIVKPKDPIQGIRKLFGKDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103M2R2</accession>
    <name>A0A103M2R2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01008940">
        <property type="protein sequence ID" value="KVF86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVF86493">
        <property type="protein sequence ID" value="KVF86493"/>
        <property type="gene ID" value="Ccrd_026642"/>
    </dbReference>
    <dbReference type="OMA" id="HAQFNTR"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000040">
        <property type="entry name" value="UDP-glycosyltransferase 76C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1392">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVF86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="488" mass="54677" checksum="71481C727D8E0034" modified="2016-04-13" version="1">MDQQKDAKTPHVLIFPMPFQGPVNCALKLAELICLSGIHVTFLNTDHIHRPLLHHTQVLSRFSRYPNFQFLTIPDGVEHEKPVSGDRFMEVMSAVDAVSKPILREMMISGSLSRKSERPVTVMIPDACFSFAVDIAIESSTPVVCFETVSPCCLWTCYLNLPTLIQAGDVPFKGKDLDELVKSVPGTENFLRRRDLASFCRSDDISTPVIELILKEARAVPRAQGLILNTFXDLDALILTHMQXLCPNIYPIGPLHSLHKARLTTPSLPKSTFSNSVWKEDETCLSWLDKHPPKTVVYVSIGSLATMTIDQLLEIWHGVVNSGKPFLWVRRPGSIIGDESLVPHELLERTKEIGCIVDWAPQEEVMAHRAIGAFLTHSGWNSTIESIKEGVPMICWPYFVDQQVNSRFVGEVWKVGVDMKDSCDRLIVEKAVRDVMETSRDMFAQHADNWANLAEKSITEKGSSSMNLARLIDDIKAMSSIIGHEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCC2</accession>
    <name>A0A103XCC2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005580">
        <property type="protein sequence ID" value="KVH88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCC2"/>
    <dbReference type="STRING" id="59895.A0A103XCC2"/>
    <dbReference type="Gramene" id="KVH88094">
        <property type="protein sequence ID" value="KVH88094"/>
        <property type="gene ID" value="Ccrd_024520"/>
    </dbReference>
    <dbReference type="OMA" id="RLMPFKA"/>
    <dbReference type="OrthoDB" id="1905234at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37744">
        <property type="entry name" value="STAR LIPID TRANSFER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37744:SF1">
        <property type="entry name" value="STAR LIPID TRANSFER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="9511" checksum="09DB0F21950F1621" modified="2016-04-13" version="1">MDKGANSGGGGGGGYWWWAAASGIQLVWGIYSFRKGYSGDSRLMPLKAFGVASLFVGATATATVGTISASGIHSVKDAVEVGASIRSGLGVKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD00</accession>
    <name>A0A103XD00_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_026741</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="LEKV01005399">
        <property type="protein sequence ID" value="KVH88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD00"/>
    <dbReference type="STRING" id="59895.A0A103XD00"/>
    <dbReference type="Gramene" id="KVH88471">
        <property type="protein sequence ID" value="KVH88471"/>
        <property type="gene ID" value="Ccrd_026741"/>
    </dbReference>
    <dbReference type="OMA" id="VCCGQFD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000077">
        <property type="entry name" value="ECA1 (ER-TYPE CA2+-ATPASE 1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112252" checksum="07331DA77FAC8BF1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD62</accession>
    <name>A0A103XD62_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005367">
        <property type="protein sequence ID" value="KVH88575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD62"/>
    <dbReference type="STRING" id="59895.A0A103XD62"/>
    <dbReference type="Gramene" id="KVH88575">
        <property type="protein sequence ID" value="KVH88575"/>
        <property type="gene ID" value="Ccrd_026441"/>
    </dbReference>
    <dbReference type="OMA" id="SRTHILM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF179">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="48424" checksum="902E269AB42C4F84" modified="2016-04-13" version="1">MENEVIEFDMGLGGGGDDAVAIIDDEEMTDDSPSAANGIMGSSSFFDPSTYVLQRDLDLEPCEGMEFESEEAAKGFYNSYARRVGFSTRVSSSRRSRKDGAIIQRSFVCAKEGFRNLNEKRTKDREIKRPRTVTRVGCKASMSVKIQDSGKWVVSTFVKEHNHELVPPDQIFMRFQEELVGTLTLMASKVEDDGEVTTYQVAKFGEDNKSYRVNFNVLEMRATCSCCMFEFSGLLCRHVLAVFRVTNVLTLPSCYILKRWTINAKSSVILEERVNDAFSSYLESHTVRYNTLRHEALKFVEEGAESVDTYNVAMSALEEAARRVAITAKNEGRVLMINGRTREDARSNGTLTKRNISNHHESLDQNLSEDEMDRKIQELNKEVECAKRKCEVYRSNLVSVLKDIEDHKQQLSLKVQIIRYSMKDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDE3</accession>
    <name>A0A103XDE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005348">
        <property type="protein sequence ID" value="KVH88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDE3"/>
    <dbReference type="Gramene" id="KVH88697">
        <property type="protein sequence ID" value="KVH88697"/>
        <property type="gene ID" value="Ccrd_026050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121">
        <property type="entry name" value="HOMEODOMAIN PROTEIN 8, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="78" mass="9195" checksum="FC3D8F2D94DABF70" modified="2016-04-13" version="1">MSFQRFQERVLKSLSMSEMDKERRLYHKDCSCALHKPKDETAKACFHHGSISYSKKLLWNKCWLTKTLSQTPSKSDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDY6</accession>
    <name>A0A103XDY6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_024222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005323">
        <property type="protein sequence ID" value="KVH88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDY6"/>
    <dbReference type="STRING" id="59895.A0A103XDY6"/>
    <dbReference type="Gramene" id="KVH88982">
        <property type="protein sequence ID" value="KVH88982"/>
        <property type="gene ID" value="Ccrd_024222"/>
    </dbReference>
    <dbReference type="OMA" id="QWGILEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="13670" checksum="B2B74C96BB096B00" modified="2016-04-13" version="1">MTLFFQDYFGGPNATMKPVTFSLDPWSFKQFGTIFYTDDPINMGMDQESGQVARAQGIYEFDGSTLEVQGASKQFERVREVAVVGGSGRFRLARGYATLGTVHLDLSLSYSIIEGNFTVWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE53</accession>
    <name>A0A103XE53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_009027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005322">
        <property type="protein sequence ID" value="KVH88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE53"/>
    <dbReference type="Gramene" id="KVH88994">
        <property type="protein sequence ID" value="KVH88994"/>
        <property type="gene ID" value="Ccrd_009027"/>
    </dbReference>
    <dbReference type="OMA" id="SMCQSGQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932:SF63">
        <property type="entry name" value="OS08G0290000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="793" mass="89752" checksum="8BB771EF23673345" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEX5</accession>
    <name>A0A103XEX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005207">
        <property type="protein sequence ID" value="KVH89503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEX5"/>
    <dbReference type="Gramene" id="KVH89503">
        <property type="protein sequence ID" value="KVH89503"/>
        <property type="gene ID" value="Ccrd_008500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="14099" checksum="4EF7CBCF618272B5" modified="2016-04-13" version="1" fragment="single">YRDQNYFIEQQYDLQLQHQKEELGVAFTRLDPPGFLCVIFDCSIAAKSSRASSTNVAKLDDLLCNLVTRRSFPSDYANTRSEFDAYSLRRANRSTSRIQASVPSHFEIRAHREGLLTTIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFF9</accession>
    <name>A0A103XFF9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005142">
        <property type="protein sequence ID" value="KVH89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFF9"/>
    <dbReference type="STRING" id="59895.A0A103XFF9"/>
    <dbReference type="Gramene" id="KVH89775">
        <property type="protein sequence ID" value="KVH89775"/>
        <property type="gene ID" value="Ccrd_008231"/>
    </dbReference>
    <dbReference type="OMA" id="RYVARTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF127">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="548"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="682" mass="77420" checksum="4B859F9A2D404CA1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFS4</accession>
    <name>A0A103XFS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-54 interaction domain, ATP-binding site 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005124">
        <property type="protein sequence ID" value="KVH89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFS4"/>
    <dbReference type="STRING" id="59895.A0A103XFS4"/>
    <dbReference type="Gramene" id="KVH89930">
        <property type="protein sequence ID" value="KVH89930"/>
        <property type="gene ID" value="Ccrd_008074"/>
    </dbReference>
    <dbReference type="OMA" id="VELWDVC"/>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000713">
        <property type="entry name" value="Ras-related small GTP-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="37150" checksum="347A224FA79D740B" modified="2016-04-13" version="1">MFWREREREINKEQNGGPPCGQVRVLVVGDSGVGKTSLVNLIVKGTSTARPPQTIGCTVDVKHFTYGTPSSSSDSIKGDKDREFFVELWDVSGHERYTDCRSIFYSQINGVIFVHDLSQRRTKTSLKKWAAEIAATGTFSAPLANGGPGGLPVPFLVIGNKADIAVKEGTRGSSGNLVDMARQWVEKQGLLPSNEELPLIDSFPGSGGLMAAAKEARYDKESVLKFFRMLVRRRYFSDELPMASPWSTSVQRPLQRPGDNLSDDDQLYTSTRTIGEAYKYNVLPPLPAQRNLTPPPTLYPQQPVLTPDNYNIPRFTLSGVQEINNIRSKRNDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFT5</accession>
    <name>A0A103XFT5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005121">
        <property type="protein sequence ID" value="KVH89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFT5"/>
    <dbReference type="STRING" id="59895.A0A103XFT5"/>
    <dbReference type="Gramene" id="KVH89968">
        <property type="protein sequence ID" value="KVH89968"/>
        <property type="gene ID" value="Ccrd_008034"/>
    </dbReference>
    <dbReference type="OMA" id="YCKSKIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000007">
        <property type="entry name" value="Alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF56">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="35362" checksum="0A96A78C0BF71673" modified="2016-04-13" version="1" fragment="single">MESKAINDLSDKDIICTAAVAWGPGQPLTIQQIRVQPPQKMEVRIKILFTSVCHTDLSSWQGLNVSQRVYPRIFGHEASGVVESVGEGVEDMKEGDHVLTIFNGECGECVYCKSKITNLCERFRVDPLQSVMRNDGKTRFLTQDGKPIYHFLNTSTFTEYTVVDSACVVKIDPKAPLDKMTLLSCCLSTVHEKIREMSEGGVDFSFECAGNLDVLREAFLSTHDGWGLTVVLGIHPTPRMLPLHPMELFDGRRITGSVFGGFKAKTQLPLFAHHCMHHQEGLKLEEFITHELPFSSIDQAFQLLINGKSLRCLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGS8</accession>
    <name>A0A103XGS8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGS8"/>
    <dbReference type="Gramene" id="KVH90425">
        <property type="protein sequence ID" value="KVH90425"/>
        <property type="gene ID" value="Ccrd_007561"/>
    </dbReference>
    <dbReference type="OMA" id="CYNTMIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF73">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="406"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="741"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="816" mass="91703" checksum="8AAA687C25E9521B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHS4</accession>
    <name>A0A103XHS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHS4"/>
    <dbReference type="STRING" id="59895.A0A103XHS4"/>
    <dbReference type="Gramene" id="KVH91021">
        <property type="protein sequence ID" value="KVH91021"/>
        <property type="gene ID" value="Ccrd_006966"/>
    </dbReference>
    <dbReference type="OMA" id="SNLTQMC"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17417">
        <property type="entry name" value="MFS_NPF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044739">
        <property type="entry name" value="NRT1/PTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="603" mass="67230" checksum="AB980B7E86C854D4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI21</accession>
    <name>A0A103XI21_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005071">
        <property type="protein sequence ID" value="KVH91176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XI21"/>
    <dbReference type="Gramene" id="KVH91176">
        <property type="protein sequence ID" value="KVH91176"/>
        <property type="gene ID" value="Ccrd_006808"/>
    </dbReference>
    <dbReference type="OMA" id="FEDTEAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF136">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2033"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2149"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2568"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1926"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2618"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1588"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1934"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2618"/>
            <end position="2633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2854" mass="313716" checksum="D9C7C79106C7BA32" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIG1</accession>
    <name>A0A103XIG1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_006582</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005031">
        <property type="protein sequence ID" value="KVH91396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XIG1"/>
    <dbReference type="Gramene" id="KVH91396">
        <property type="protein sequence ID" value="KVH91396"/>
        <property type="gene ID" value="Ccrd_006582"/>
    </dbReference>
    <dbReference type="OMA" id="HETSGMV"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000043">
        <property type="entry name" value="Cytochrome P450 99A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF13">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56252" checksum="77359D4530BEB218" modified="2016-04-13" version="1">MDTIITILLIVSSLILSFYFVLNKKPKALNLPPGPPKLPLIGNLHQVAGALPHRVFRDLASRYGPIMHVKLGQINSVVISSPRLAKEVLKTNDIAIADRPYVLLAELVLSGNQGIVLAQYGEYWRQMKKILSLQLLSVKKVRSFQXIREQEIGRMLEAFRLSSGKPVNIHAKVAQGINSVVCISAFGSNCRQQHRLIEFMEAMERETSGMSDMFPDLEFLDKFKRRSRVMQLKKTYDDLLDDILDEHRQRKRDGDQAEEEEGLLGSLLKIREEGGLEFPITNNVLKALFLDVFAGGTDTSTATVEWAMTELIKHPTIMSKVQAEIRAALKGKTVITEADLQDLSYMQCIIRETLRLHPPFPLLVPHDCREQCKIDGYDIPVKYRVFINAWACATHPEYWEDPDSFKPERFQKTSVDFLGNDYQFLPFGSGRRICPGIYFGLRTTELFLAQMLNNYDWKLPHGLTPSNVDTAETLGGGVLVTKKNSLHLIPTLYSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ99</accession>
    <name>A0A103XJ99_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chlorophyll A-B binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ELIP/psbS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004911">
        <property type="protein sequence ID" value="KVH91688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XJ99"/>
    <dbReference type="Gramene" id="KVH91688">
        <property type="protein sequence ID" value="KVH91688"/>
        <property type="gene ID" value="Ccrd_006282"/>
    </dbReference>
    <dbReference type="OMA" id="QSEPDMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="248" mass="25947" checksum="78D06E246C6CC388" modified="2016-04-13" version="1" fragment="single">MAATSVFMATPFTRLSATQLPSFHKNSAFSVRCMSSQLPNDAETKSKTPPPPAPKVSTKFTDVLXFSGPAPERINGRLAMIGFVATMAVELSSGQDVFTQISNGGVAVFVVTSVVLSVASLVPLLKGVSVQSKSKGIMTSDAELWNGRFAMLGLVAPERINGRLAMIGFVATMAVELSSGQDVFTQISNGGVAVFVVTSVVLSVASLVPLLKGVSVQSKSKGIMTSDAELWNGRFAMLGLVGLAFTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK17</accession>
    <name>A0A103XK17_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004836">
        <property type="protein sequence ID" value="KVH92193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK17"/>
    <dbReference type="STRING" id="59895.A0A103XK17"/>
    <dbReference type="Gramene" id="KVH92193">
        <property type="protein sequence ID" value="KVH92193"/>
        <property type="gene ID" value="Ccrd_005780"/>
    </dbReference>
    <dbReference type="OMA" id="YDANITS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF263">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="6">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="40457" checksum="A554C6F4F8B0BA06" modified="2016-04-13" version="1">MGKASRWIRNLLMGKKEEKMNNKAIISALTPLSQSQSQSQSQSPSERRRRWSFRRSNNTEKVSIISHKSCRSFDSQLFHYSLIHHQPPPNVYIGSHMVAVASATKIQAAFRSYLARKALCALRGLVKLQALVRGHLVRKRTTTMVRCMKALVSIQVRARYQRIQLVEDAESRSLTKRGSMMAHKRRLSASQYDHNETIGHFGSKTSTCIRYRQSSRRFSIDSLPSTHDKSMRLHDKLIDEVSTKSQMNTQNTEPNYMTRTKSSRAKTRSHSEPRQRPTKQNRGNRQNEDLGAIRKEVQTHNHQKDHEGWLAKLRTSSNSSSDFEFDSASTCTNSSSYRTALYAYGVHKSSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKE5</accession>
    <name>A0A103XKE5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004820">
        <property type="protein sequence ID" value="KVH92401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKE5"/>
    <dbReference type="STRING" id="59895.A0A103XKE5"/>
    <dbReference type="Gramene" id="KVH92401">
        <property type="protein sequence ID" value="KVH92401"/>
        <property type="gene ID" value="Ccrd_005582"/>
    </dbReference>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="329" mass="36636" checksum="6FE79C5D0DC1A010" modified="2016-04-13" version="1">MIRTHKLSSITRRSQSNPLRKLSILREKSSKKDSRTMAPPILSLALPSETGRVLSIQSHTVQGYVGNKSAVFPLQLLGYDVDPIMSVQFSNHTGYPTFKGQVLNGKQLWELIEGLEANNLLYYTHLLTGYIGSVSFLNTVLEVVSKLRSINPTLTYVCDPVMGDEGKLYVPPELVSVYREKVVPVASMLTPNQFEAEQLTGFRIASEQDGREACRHLHAAGPSKVVITSICIDGNLLLIGSHQKEKGQSPVQFKIVIPKIPAYFTKYPNNLDKAAELAVSSLQAVLSRTLKDYEEAGYDPQTSSLEIRLIQSQDDIRNPEIEYTSHLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKL5</accession>
    <name>A0A103XKL5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional coactivator Hfi1/Transcriptional adapter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKL5"/>
    <dbReference type="STRING" id="59895.A0A103XKL5"/>
    <dbReference type="Gramene" id="KVH92445">
        <property type="protein sequence ID" value="KVH92445"/>
        <property type="gene ID" value="Ccrd_005498"/>
    </dbReference>
    <dbReference type="OMA" id="CCRNSGE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF36">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR HFI1_TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="44550" checksum="8D7401A12909E4CB" modified="2016-04-13" version="1" fragment="single">IDNSALRQQVKFDFDSRVKEEIEKSLGSQKAEKYFNLLTRYLSLNLRKSEFNKLCFGLIGRENIHLHNELIMAIVKNATVSKIPPQKHVKSDGPVTLKLPNGTNPRTGLQSLCRDAFPRSPRKGRTPNLRERKFKDRASPIGLHEKTRTSEDLAATKIQEQQSATELLSLGSKPPVEVNSVEDGEEVEQGVISPGVHSRSPVRAPLGISIHSKETRKVLCSGSDSAYYTETCHYNGRLPATNSLKNRLKHNLKTESLDISNDCVNLLNNGLDSFLKMVIKPSLELARSRSSQRAGTSYSTSMLDFRVATQINPKILGEFSHLQHKSLVSVSGSLMAAWILFGRFAGWRAMSSPYSWILIQPRDYSYHNILQDFSKKTVGFGAVGYILYTIRYLWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLT3</accession>
    <name>A0A103XLT3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IQ motif, EF-hand binding site-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004794">
        <property type="protein sequence ID" value="KVH93137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLT3"/>
    <dbReference type="STRING" id="59895.A0A103XLT3"/>
    <dbReference type="Gramene" id="KVH93137">
        <property type="protein sequence ID" value="KVH93137"/>
        <property type="gene ID" value="Ccrd_004849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF134">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15607" checksum="A1F8D0FBED2142F5" modified="2016-04-13" version="1">MVTESRIKQKKLQNHLKLESKLHELEVEWCGGPGTMDEIVSKIHQREEASNKRERAMAYAFSHQWRANSNLSFGQAYYDLSKESWGWSWMERWIAICPWETRVVARPTVLNQRKKPKETKTLVAKVGTEKGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN96</accession>
    <name>A0A103XN96_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_003979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="LEKV01004580">
        <property type="protein sequence ID" value="KVH93961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN96"/>
    <dbReference type="Gramene" id="KVH93961">
        <property type="protein sequence ID" value="KVH93961"/>
        <property type="gene ID" value="Ccrd_003979"/>
    </dbReference>
    <dbReference type="OMA" id="RGNCGNC"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000061">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000076">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000142">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000021">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118960" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="10">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase beta-sandwich" evidence="11">
        <location>
            <begin position="362"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="12">
        <location>
            <begin position="468"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="12">
        <location>
            <begin position="617"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH93961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="725" mass="81344" checksum="234A21DEAF80DCF6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNE2</accession>
    <name>A0A103XNE2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Senescence regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004585">
        <property type="protein sequence ID" value="KVH93938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNE2"/>
    <dbReference type="STRING" id="59895.A0A103XNE2"/>
    <dbReference type="Gramene" id="KVH93938">
        <property type="protein sequence ID" value="KVH93938"/>
        <property type="gene ID" value="Ccrd_004014"/>
    </dbReference>
    <dbReference type="OMA" id="TRNDHAG"/>
    <dbReference type="OrthoDB" id="1917735at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525">
        <property type="entry name" value="EMB|CAB72159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525:SF2">
        <property type="entry name" value="EMB|CAB72159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="181" mass="20897" checksum="5461DFFF86589E26" modified="2016-04-13" version="1">MATRKFHHHHHDQRSKFLNYLGGGGGGGGGDQRINRVDSDGFEMNESDLWNTSVDDHSHLQPQNTISRRSKFPLKAHQQRKMPMTSAAKSLPVNVPDWSKILRDEYKHHGRRDNDHGHDVGFYDDDDEEEDDNEKLPPHEYLARTRIASFSVHEGFGRTLKGRDLSRVRNAIWKQTGFEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNU2</accession>
    <name>A0A103XNU2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004571">
        <property type="protein sequence ID" value="KVH94085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNU2"/>
    <dbReference type="STRING" id="59895.A0A103XNU2"/>
    <dbReference type="Gramene" id="KVH94085">
        <property type="protein sequence ID" value="KVH94085"/>
        <property type="gene ID" value="Ccrd_003854"/>
    </dbReference>
    <dbReference type="OMA" id="HYLNFHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00352">
        <property type="entry name" value="Gn_AT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000055">
        <property type="entry name" value="Asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF48">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="493" mass="55592" checksum="1C215D98FA1ABFCF" modified="2016-04-13" version="1">MLDGMFSFVLLDTRDNTYIAARDAIGITPLYIGWGLDGSVWISSELKGLNDDCEHFQAFPPGHLYSSKTAGFRRWYNPPWFSEAIPSTPYDPLVLRGAFENAVIKRLMTDVPFGVLLSGGLDSSLVASITARHLSGTKAAKQWGAQLHSFCVGLEGSPDLKAAREVADYLGTVHHEFHFTVQDGIDAIEDVIYHIETYDVTTIRASTPMFLMSRKIKSLGVKMVISGEGSDEIFGGYLYFHKAPNKEEFHRETCRKIKALHQYDCLRANKSTSAWGLETRVPFLDKEFINVAMSIDPEAKMINMEQKRIEKWILRRAFEDEEHPYLPKHILYRQKEQFSDGVGYSWIDGLKAHAKLHVNIPDPLVLGFLFNNTNPLRYLQVTDKMMLNAEHIFPHNTPVTKEAYYYRMIFERFFPQNPAKLTVPGGASIACSTEKAIEWDASWSKNLDPSGRAALGVHNDAYKQNAVPVASANIMDKMPRMMDIATPGVVIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ68</accession>
    <name>A0A103XQ68_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_003058</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01004511">
        <property type="protein sequence ID" value="KVH94881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ68"/>
    <dbReference type="STRING" id="59895.A0A103XQ68"/>
    <dbReference type="Gramene" id="KVH94881">
        <property type="protein sequence ID" value="KVH94881"/>
        <property type="gene ID" value="Ccrd_003058"/>
    </dbReference>
    <dbReference type="OMA" id="STFMDTP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF370">
        <property type="entry name" value="LACCASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="355"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH94881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="504" mass="55680" checksum="DD3466FEB2821CB9" modified="2016-04-13" version="1">MQEKGFRWVVMKQASRLCSTKPIVTVNGQFPGPTLYAREGDNVLVRVVNHVKYNVSIHWYDTQCPIQPGQNYVYNFTITGQRGTLFWHAHILWLRATVHGAIVILPKQGVPYPFPKPDVEQVVVLGESSTGKKNLKRHCIECEWWKSDTEAVIKQALKSENGKSYMLRIINAALNEELFFKIAGHQLTVVEVDATYVKPFTTDTVVITPGQTTNVIVTTNKNSGKFMMAASTFMDSPIAIDNKTAIATLHYTGTLSNSPTTLTTPPPQNATATANNFIDSLRSLNSKKFPANVPLKIDHSLYFTVGLGINPCPSCKAGNGSRVVAGINNITFVMPTTALLQAHYFNQKGVFTTDFPGNPPKSFNYTGAPPKNLATTSATKLYKLKYNSTVQLVLQDTSLISPENHPIHLHGFNFFAVGKGLGNYNPKVDPNNFNLVDPVERNTIGVPSGGWVAIRFRADNPGVWFMHCHLEIHTSWGLKMAFLVENGEGPNESLLPPPKDLPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQD2</accession>
    <name>A0A103XQD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor sulfurase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004516">
        <property type="protein sequence ID" value="KVH94844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQD2"/>
    <dbReference type="STRING" id="59895.A0A103XQD2"/>
    <dbReference type="Gramene" id="KVH94844">
        <property type="protein sequence ID" value="KVH94844"/>
        <property type="gene ID" value="Ccrd_003089"/>
    </dbReference>
    <dbReference type="OMA" id="WRWVRIG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF77">
        <property type="entry name" value="MOSC BETA BARREL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="27738" checksum="0B06B09C3F5901AD" modified="2016-04-13" version="1">MAEVDKDGGSAAAAGGGGKAPTVKSIFVYPIKSCRGISVSQALLCSTGFVWDRQWVVVNSKGRGCTQRVEPKLALIQVELPIEAFSQGWVPKNTSYLVVRAPGMAELMVPLTKPSLQSDGVSVWEWSGTALDEGDKAAKCIFVDGCEPFAEDLWKQIKINELTFQGVMLCPRCKVPTINQEDAMQGSEPTETMMKFRSAKALEVNATKTKYKGRVYLGQMLVCEDKDSSWRKVINVGDIIHVEKILPSYADVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQF2</accession>
    <name>A0A103XQF2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004471">
        <property type="protein sequence ID" value="KVH94996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQF2"/>
    <dbReference type="STRING" id="59895.A0A103XQF2"/>
    <dbReference type="OMA" id="GMRTASM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF128">
        <property type="entry name" value="K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="161"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="30266" checksum="437CB2FCB7F6554F" modified="2016-04-13" version="1" fragment="single">LLNLTALFGVCLPPLISKTRTLFTPLFASCCYPFSAYAGFSMSSFYSPNFSPARAVSPQITDADSQYLSELLAEHQKLQPFMQVFPVCTRLLNQGMLQSQGINELDRLRHRSPSPMASSDLMSHVPGTGWNGFPQERLSGPPGMTMDWQGGAPASPSSYTVKRILRLDIPVDTYPNFNFVGRLLGPRGNSLKRIEATTGCRVYIRGKGSIKDPDKEEKLRGRPGYEHLNEPLHILIEADLPASVVEIRLRQAHEIIQELLKPVFVLMDDCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRK5</accession>
    <name>A0A103XRK5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_002394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004383">
        <property type="protein sequence ID" value="KVH95534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRK5"/>
    <dbReference type="STRING" id="59895.A0A103XRK5"/>
    <dbReference type="Gramene" id="KVH95534">
        <property type="protein sequence ID" value="KVH95534"/>
        <property type="gene ID" value="Ccrd_002394"/>
    </dbReference>
    <dbReference type="OMA" id="ETQSNDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009723">
        <property type="term" value="P:response to ethylene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009739">
        <property type="term" value="P:response to gibberellin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000009">
        <property type="entry name" value="transcription factor MYB1R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052245">
        <property type="entry name" value="Plant_Stress_Dev_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44191:SF83">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44191">
        <property type="entry name" value="TRANSCRIPTION FACTOR KUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH95534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="41025" checksum="8643089A3DCD4AF6" modified="2016-04-13" version="1">MTRRCSHCSNNGHNSRTCPNRGLKLFGVRITDGSIRKSASMGNLTHYTGSGSGAFNASFAAAGADLDSPGDTPDHNAAADGYASEDFVAGSSSSRERKKGVPWTEEEHRMFLLGLQKLGKGDWRGIARNYVISRTPTQVASHAQKYFIRQSNMSRRKRRSSLFDIVADDVCIFHLVHLCIFVVVLAGEPVFLDEGNSREEKCLPLLCDLKPLDLSMMASHDYNDGNTSQPETQSINDPMCVPTLEEKEEECESTDSTNSNIVEVAADLTTNLMHQEGRQYCYPGMFPAFIPVAIPFWPGGSVPGPQAESHKVLKPTAVHSKNPINVDELVGLSKLSLGKSTGDGGPNSLKLVGSLSRPSAFHANNPNQGSTGHSPIHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRT5</accession>
    <name>A0A103XRT5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein ACR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein ACT DOMAIN REPEATS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds amino acids.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRT5"/>
    <dbReference type="Gramene" id="KVH95702">
        <property type="protein sequence ID" value="KVH95702"/>
        <property type="gene ID" value="Ccrd_002214"/>
    </dbReference>
    <dbReference type="OMA" id="CTTHTER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04897">
        <property type="entry name" value="ACT_ACR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040217">
        <property type="entry name" value="ACR1-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096:SF15">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24931">
        <property type="entry name" value="ACT_ACR9_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="178"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="296" mass="33370" checksum="B376D7B6FB8A56BA" modified="2016-04-13" version="1">MASIVYIVDEQSGSPIEDVDRLAKIKQLLVFILKGDRDRRGAQTTVSVGSTHTQRRLHQLMYADRDYDKELTGEYDRAESSCGVKRLVTVENCSEKGYTVVNLRCPDRPKLLFDTVCTLTDMQYVVFHATIVVEGSEASQEFYIRHTDGCPISSEAERQRVIDCLEAAIKRRTSEGLRLELCGEDRTGLLSDVTRIFRENGLSVTRAEVTTRGSKVVNTFYVMDSSGDHVKSETIEAIRTAMGESMINMKEDDTVKPNPKPNLQQTGRFSLSHLFRSRSEKFLYNLGLISSYSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRY5</accession>
    <name>A0A103XRY5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004376">
        <property type="protein sequence ID" value="KVH95798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRY5"/>
    <dbReference type="STRING" id="59895.A0A103XRY5"/>
    <dbReference type="Gramene" id="KVH95798">
        <property type="protein sequence ID" value="KVH95798"/>
        <property type="gene ID" value="Ccrd_002115"/>
    </dbReference>
    <dbReference type="OMA" id="HELTQWN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000281">
        <property type="entry name" value="Calcium-binding EF hand family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF101">
        <property type="entry name" value="CALCIUM-BINDING EF HAND FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119045" evidence="3">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="42719" checksum="7BE91761C4678DEE" modified="2016-04-13" version="1">MGKVSVIIYITIALLLLLLISQSPNKSNNRNNNRRHRRLKLRSNFSFTPTTTTTAAAEHHVSFDPLVADIERKREDRLWEKSHFFDDHHHEGEEEPEAHAAPGMESQPEWEDFIDAEDYLNDEHKFNITHRLVLLFPRIDVDPSDGFVTEHELTEWNLEQSQREVLHRSQREMELHDKNHDGLVSFAEYQPPTWVRDSDNNSFGYDMGWWKEEHFNASDADEDGFLNITEFNEERDTDKDGKVNFKEFFHGLFDLVRNYDEDGHNSSHESSDSLESPARTFFAELDKDGDGYLSDVELLPIIGKLHPSERYYAKQQADYIISQADTDKDGRLSLTEMIDSPYVFYSAIFNEDEDEDYEYHDEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSR4</accession>
    <name>A0A103XSR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004348">
        <property type="protein sequence ID" value="KVH96196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSR4"/>
    <dbReference type="STRING" id="59895.A0A103XSR4"/>
    <dbReference type="Gramene" id="KVH96196">
        <property type="protein sequence ID" value="KVH96196"/>
        <property type="gene ID" value="Ccrd_001719"/>
    </dbReference>
    <dbReference type="OMA" id="AMRGEIM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000530">
        <property type="entry name" value="ABC transporter G family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF73">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER STR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="42"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="797" mass="89721" checksum="5ACFDFF636497059" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT22</accession>
    <name>A0A103XT22_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004328">
        <property type="protein sequence ID" value="KVH96343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT22"/>
    <dbReference type="Gramene" id="KVH96343">
        <property type="protein sequence ID" value="KVH96343"/>
        <property type="gene ID" value="Ccrd_001572"/>
    </dbReference>
    <dbReference type="OMA" id="YNFYNMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="110"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="31571" checksum="2F3FC5FC6E5A7063" modified="2016-04-13" version="1">MNHTHSLLPQVNHPLLSNNPHVLVPFLELKLYLENENPDLSSFTSPRLFSTHMPYVSLPKSVHDSQSKLVYLCRNPKDTLVSLWFFTNKLRLKEMGTNPLEDAFEKFCAGVLVSLWFFTNKLRLKEMGTNPLEDAFEKFCAGVSIYGPFWDHMLGYWKESLNNPQRVFFLKYEEMKEQPELHLKKLADFLGCSFSSKEEEERTVDDILEICSFDNLSNLKVNKEGKLPSGEDFSAFFRKGEVGDWKNHLTPEMVERLDNICEEKFQGSGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT70</accession>
    <name>A0A103XT70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpene synthase, metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004317">
        <property type="protein sequence ID" value="KVH96406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XT70"/>
    <dbReference type="Gramene" id="KVH96406">
        <property type="protein sequence ID" value="KVH96406"/>
        <property type="gene ID" value="Ccrd_001508"/>
    </dbReference>
    <dbReference type="OMA" id="SFEWIST"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF221">
        <property type="entry name" value="(-)-GERMACRENE D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="266" mass="31106" checksum="27325B6384F0656F" modified="2016-04-13" version="1">MLPEYMKFIYQELLDVHKEDEELLEKKGMAYRSYYTKEMVKEYTRNLLTEAKWVKEGYIPTIEEHMSVTLVTCAYAMIIAKCYVHGHDSVXEDTFKWVSTYPPLVKASCLILRLMDDIATYKEEQERNHCASSIQCYMKQHGVSEEETREVFSKQVEDAWKVINQESLRPTDVPMPLLMPPINLARVCDELYSRGDDYNHAGKEMIHCIESLLITDVLLRRIFYMLRYGVPMVSFLMDSDVFWFKAAMMNRPIIDDTITTCLDGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT81</accession>
    <name>A0A103XT81_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CheY-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_001446</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARR family. Type-B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004302">
        <property type="protein sequence ID" value="KVH96468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT81"/>
    <dbReference type="Gramene" id="KVH96468">
        <property type="protein sequence ID" value="KVH96468"/>
        <property type="gene ID" value="Ccrd_001446"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17584">
        <property type="entry name" value="REC_typeB_ARR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000007">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000408">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF197">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="44"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH96468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="608" mass="66657" checksum="E07054FF15655A74" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTA9</accession>
    <name>A0A103XTA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004275">
        <property type="protein sequence ID" value="KVH96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTA9"/>
    <dbReference type="STRING" id="59895.A0A103XTA9"/>
    <dbReference type="Gramene" id="KVH96513">
        <property type="protein sequence ID" value="KVH96513"/>
        <property type="gene ID" value="Ccrd_001384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37247:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119101" evidence="2">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="275" mass="31064" checksum="FA2C0A6D651046B7" modified="2016-04-13" version="1">MPFICDFFCCLLTLLLVYCSYINNRMALILDSVTTFTEIEILVIEVSCVKAVIEFEKSNLDTTPKLQPEVTPPPFPKKAVTGSVLLFFCNIFIYQEFLFHSGIGITFAKALLPTQKLIGNKSIDYRRSWLVFEKISRTRPRHFVREGYGAKYAISVGRGNHELSLHNDVKEPFWLAPTKGFISGVKSLFAFLAEQPSQLKYIEWPGFQNTVSICTLNLALFPGFNISGHKSTRSLEFFVKTACLTLVLVAMLIVVLSSVDSGLWYLLVKILRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTJ6</accession>
    <name>A0A103XTJ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004259">
        <property type="protein sequence ID" value="KVH96650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTJ6"/>
    <dbReference type="STRING" id="59895.A0A103XTJ6"/>
    <dbReference type="Gramene" id="KVH96650">
        <property type="protein sequence ID" value="KVH96650"/>
        <property type="gene ID" value="Ccrd_001260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13612" checksum="98CF40EC3281BAE4" modified="2016-04-13" version="1">MVLVCPRLRKGQIRVEHYASKQAKFIVAHDSRIVCLALTHDGRLLATASSKGTLIRIFNILDGSFFQDSIWWQRPPNSLRKLKQQLTQLRRSFSTLMGLVENANYSRILNDGDSLPRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTX7</accession>
    <name>A0A103XTX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HR-like lesion-inducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004209">
        <property type="protein sequence ID" value="KVH96765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XTX7"/>
    <dbReference type="Gramene" id="KVH96765">
        <property type="protein sequence ID" value="KVH96765"/>
        <property type="gene ID" value="Ccrd_001143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008637">
        <property type="entry name" value="HR_lesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474">
        <property type="entry name" value="HR-LIKE LESION-INDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05514">
        <property type="entry name" value="HR_lesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="11395" checksum="113C20E6CBD2F135" modified="2016-04-13" version="1" fragment="single">MFDSGSRFNEFGNDGGSAAKTLVPKFSVFSKHVTAHTGFQIKIXVAGAIALKGIXSLLFIFGSTIGAFLLILHQLIATPILYDFYNYDVDKKEFSQLFIKFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUD2</accession>
    <name>A0A103XUD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Senescence regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003862">
        <property type="protein sequence ID" value="KVH97085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUD2"/>
    <dbReference type="STRING" id="59895.A0A103XUD2"/>
    <dbReference type="Gramene" id="KVH97085">
        <property type="protein sequence ID" value="KVH97085"/>
        <property type="gene ID" value="Ccrd_000819"/>
    </dbReference>
    <dbReference type="OMA" id="KVAYSIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083:SF49">
        <property type="entry name" value="SENESCENCE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="14060" checksum="F5BBCD81B6A5098C" modified="2016-04-13" version="1">MDEEFDESEVTFAEVEAHGMQENHTEWKDDKLKTKSKKKKKEHSVPINIPKKIPCVKYVESDLFEDDYGNEIIVPPHVILGRRVARQVAYSICSGCGKTSKKRELILVRDLFFRFTGFIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUS3</accession>
    <name>A0A103XUS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUS3"/>
    <dbReference type="STRING" id="59895.A0A103XUS3"/>
    <dbReference type="Gramene" id="KVH97251">
        <property type="protein sequence ID" value="KVH97251"/>
        <property type="gene ID" value="Ccrd_000654"/>
    </dbReference>
    <dbReference type="OMA" id="CNAQHES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212">
        <property type="entry name" value="ADHESIN-LIKE PROTEIN, PUTATIVE (DUF3741)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212:SF17">
        <property type="entry name" value="DUF4378 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="461"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="616" mass="70672" checksum="67FE2E82B40CCC24" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWE6</accession>
    <name>A0A103XWE6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterile alpha motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWE6"/>
    <dbReference type="STRING" id="59895.A0A103XWE6"/>
    <dbReference type="Gramene" id="KVH98121">
        <property type="protein sequence ID" value="KVH98121"/>
        <property type="gene ID" value="Ccrd_023669"/>
    </dbReference>
    <dbReference type="OMA" id="RTMRVSP"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="34148" checksum="2333ADB622F9418C" modified="2016-04-13" version="1">MAEVQPPVEGLVNGGGAGGAVVPMVSVPVEPVAGPTKRQRRPSVRLGEIGDQHTYDNHRRSKQQQQQWKYASKESKTSKTRQLMNLSGGGAMEYHETLDGGGDDKDGGNKSNHNLGNGNNNNNNNNPLDCVAIGSWKVRDSAKSKRGFSMLTKRVRSNWTSKMDDGDEKFEDEVDYDDDGYRDFDREGSASQLKEQSLNLSMDYERDLHRSRDGTRVRVSDGVELDGPSDTDARNWNNNNPERNGVRVWLNQLGLGRYFPIFEVHEVDDEVLPLLTLEDLKDMGINAVGSRRKMFCSIQKLGKGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXI6</accession>
    <name>A0A103XXI6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">phosphopantothenoylcysteine decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003740">
        <property type="protein sequence ID" value="KVH98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXI6"/>
    <dbReference type="STRING" id="59895.A0A103XXI6"/>
    <dbReference type="Gramene" id="KVH98735">
        <property type="protein sequence ID" value="KVH98735"/>
        <property type="gene ID" value="Ccrd_023037"/>
    </dbReference>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000004">
        <property type="entry name" value="Phosphopantothenoylcysteine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Flavoprotein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="212" mass="23420" checksum="7ACEFF92C5117A65" modified="2016-04-13" version="1">MAYAEPIHGIREPMQVSTAPRKPRILLAASGSVAAIKFGNLCSCFSDWADVKAVATQAALHFIDRTSLPKDVILYTDEHEWSSWSKIGDSVLHIELRRWADIMVIAPLSANTLGKIAGGLCDNLLTSIIRAWDYEKPIFVAPAMNTFMWTNPFTERHLMSIDELGITLIPPVSKRLACGDYGTGAMAEPSLIFSTVRLFLESRQNASSSRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYQ0</accession>
    <name>A0A103XYQ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003584">
        <property type="protein sequence ID" value="KVH99365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XYQ0"/>
    <dbReference type="Gramene" id="KVH99365">
        <property type="protein sequence ID" value="KVH99365"/>
        <property type="gene ID" value="Ccrd_022401"/>
    </dbReference>
    <dbReference type="OMA" id="WLLETEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="327"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1394"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1490" mass="165269" checksum="4BE982C11C4C7B57" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYX3</accession>
    <name>A0A103XYX3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">NAD(P)H dehydrogenase subunit 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">NADH-plastoquinone oxidoreductase subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_022308</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003517">
        <property type="protein sequence ID" value="KVH99458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYX3"/>
    <dbReference type="STRING" id="59895.A0A103XYX3"/>
    <dbReference type="Gramene" id="KVH99458">
        <property type="protein sequence ID" value="KVH99458"/>
        <property type="gene ID" value="Ccrd_022308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002128">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chlpt_su5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01010">
        <property type="entry name" value="Proton_antipo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="8" id="KW-0874">Quinone</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal" evidence="21">
        <location>
            <begin position="128"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH99458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="302" mass="34702" checksum="AD0D03C89F5DBF8E" modified="2016-04-13" version="1">MSGILCTTFLAIRRTGIEPAHGGFTIHCLDPLGYIRPYYLVLSTITILAFVLWWVSEILSMTYVVLKGYLYNPIDCVKPAVAAEAGKSYILSLWTEEKGGMAERGLYHERSKKVFFEEDQKDIPFPFLQNYSGKKNIPFYSISLWGKEGSKIGNKKFRLVTLLKMKKNGHASFFPNKVYKLDENVRNMIQPFLSIPHFGNTKTHSYPYESDNTLLSLVLILIIFTLFVGFLGIPFNQDGVNLYILSKWLTPSINLLNKNSNNSIDWYEFCKDAVFSVSIASFEIFIAFFYINLLIHLFKIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ36</accession>
    <name>A0A103XZ36_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extensin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003451">
        <property type="protein sequence ID" value="KVH99545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ36"/>
    <dbReference type="STRING" id="59895.A0A103XZ36"/>
    <dbReference type="Gramene" id="KVH99545">
        <property type="protein sequence ID" value="KVH99545"/>
        <property type="gene ID" value="Ccrd_022220"/>
    </dbReference>
    <dbReference type="OMA" id="SICPGAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36586:SF54">
        <property type="entry name" value="EXTENSIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36586">
        <property type="entry name" value="PROLINE-RICH EXTENSIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119218" evidence="2">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="29212" checksum="16C6BA3B799A7AD3" modified="2016-04-13" version="1">MGTKGHTMATLLITLAVVIVSLSLPSLTTADYPHSPPPPKKSPPPPPPPHYVYKSPPPPPPVYKSPPPPVYKSPPPPPPVYKSPPPPTPVHKSPPPPKKPYVYKSPPPPTPVHKSPPPPNKPYVYKSPPPPTPVHKSPPPPKKPYVYKSPPPPTPVHKSPPPPTPIHKSPPPPKKPYVYKSPPPSSPVYKSPPPPTPVHKSPPPPKKPYVYKSPPPPTPVYKSPPPPAPVHKSPPPPSPKKPYVHKSPPPPVKKSPPTHYFYSSPPPPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZQ0</accession>
    <name>A0A103XZQ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_021900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003409">
        <property type="protein sequence ID" value="KVH99859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZQ0"/>
    <dbReference type="STRING" id="59895.A0A103XZQ0"/>
    <dbReference type="Gramene" id="KVH99859">
        <property type="protein sequence ID" value="KVH99859"/>
        <property type="gene ID" value="Ccrd_021900"/>
    </dbReference>
    <dbReference type="OMA" id="MEAHEEF"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016679">
        <property type="entry name" value="TF_GATA_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016992">
        <property type="entry name" value="TF_GATA_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH99859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="39434" checksum="FDDE2EE257AABF46" modified="2016-04-13" version="1">METPPQFFTLDKRHSDVKTEHFIIDDLLNFPTDEILPDDHDDHKIHLLPYNNNNNTTTDSSNLTTGAAAVDSCNSSVCGATDLNFTGEVARRTFTDTQFSHDLGVPYDDMAELEWLSNFVEESFSSEDMEKLQLISGVKPRPDDPSETHQFQHETDNRTTNPIFNTDMTVPGKARTKRSRAAPCNWTSRLLVLSPTSTGPTATMSSESESDIVSTSTGKKTVKAPPKKKEVFENASHNGEGRKCLHCATDKTPQWRTGPLGPKTLCNACGVRYKSGRLVPEYRPAASPTFVLTKHSNSHRKVLELRRQKEMQRAHPQPFFHHQNMMFDVPKGPDDYLIHQHIGPDYRQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0Z6</accession>
    <name>A0A103Y0Z6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zer-1-like leucine-rich repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003381">
        <property type="protein sequence ID" value="KVI00532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y0Z6"/>
    <dbReference type="Gramene" id="KVI00532">
        <property type="protein sequence ID" value="KVI00532"/>
        <property type="gene ID" value="Ccrd_021224"/>
    </dbReference>
    <dbReference type="OMA" id="CESIGQC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF313">
        <property type="entry name" value="TIR DOMAIN, P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="575" mass="65277" checksum="4AE4EAF0A6264D99" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y108</accession>
    <name>A0A103Y108_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003377">
        <property type="protein sequence ID" value="KVI00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y108"/>
    <dbReference type="Gramene" id="KVI00551">
        <property type="protein sequence ID" value="KVI00551"/>
        <property type="gene ID" value="Ccrd_021197"/>
    </dbReference>
    <dbReference type="OMA" id="ANFCFYL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000024">
        <property type="entry name" value="Eukaryotic translation initiation factor 4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1238"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1372"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1488"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1564"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1746" mass="188702" checksum="26F3FD218BFC4C0A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1C1</accession>
    <name>A0A103Y1C1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003350">
        <property type="protein sequence ID" value="KVI00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1C1"/>
    <dbReference type="Gramene" id="KVI00698">
        <property type="protein sequence ID" value="KVI00698"/>
        <property type="gene ID" value="Ccrd_021046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="8212" checksum="F63154ACB7FE11A6" modified="2016-04-13" version="1">MYEIVDPYHPTDTSRSHPSSTFNVSSEVIKTGCVTTSILSGMRNRGHVASLGKFGSEHHVKGPFIIQGDKEPHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1S9</accession>
    <name>A0A103Y1S9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">14-3-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003163">
        <property type="protein sequence ID" value="KVI00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1S9"/>
    <dbReference type="STRING" id="59895.A0A103Y1S9"/>
    <dbReference type="Gramene" id="KVI00938">
        <property type="protein sequence ID" value="KVI00938"/>
        <property type="gene ID" value="Ccrd_020801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="15239" checksum="B9028ED8AC5B3F35" modified="2016-04-13" version="1" fragment="single">MEHEKNKSDSIELSKRRICSSITGVAQSITIIFLFIDHQCRLYESQFVVSWGNEDHVSVIKNYRSKIEKELSDIGDGILKMLDKKLVPSASSGDSNVFYLKMKGDYHRYLPEFKTGGERKEAAESTLNAYKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2M8</accession>
    <name>A0A103Y2M8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003110">
        <property type="protein sequence ID" value="KVI01371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2M8"/>
    <dbReference type="STRING" id="59895.A0A103Y2M8"/>
    <dbReference type="Gramene" id="KVI01371">
        <property type="protein sequence ID" value="KVI01371"/>
        <property type="gene ID" value="Ccrd_020363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="41641" checksum="1BA349CE97201DF4" modified="2016-04-13" version="1">MVVIEPVPSTDIEPESSNSTTARVDSSNNNRANVDGVDSRNGDKATAAGYASDGYETASETKVGDDETVSDKNDTRNAVGNYQKHKLEEISVVSKDQTYEDALNEDELKQCNDCLAVSGFNLVKAYSPTYLGSSYAQNVEVVIICFLLNSLEDLLKNLSLEFTVFLLVDYCSPKILAQMNEAKVEGNKLFGDGLYQEALLKYDYAIQLAPEMSSSSEIRSICHNNRATCFCKLSPMEAEHGVRWRVYGGCDGEEEGGNYEDTIKECTKALEINPTYMKALLRRGEAHEKLKNYDEAIADMKKILELDPSNHQAKRTIIRLEPLAIEKREKMKEEMIGKLKDMGNTILGKFGMSVDNFKAVQDPNTGSYSISFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2R0</accession>
    <name>A0A103Y2R0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003090">
        <property type="protein sequence ID" value="KVI01454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2R0"/>
    <dbReference type="Gramene" id="KVI01454">
        <property type="protein sequence ID" value="KVI01454"/>
        <property type="gene ID" value="Ccrd_020277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022251">
        <property type="entry name" value="DUF3774_wound-induced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33090">
        <property type="entry name" value="DUF3774 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12609">
        <property type="entry name" value="DUF3774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18128" checksum="5E684E2F422DCF23" modified="2016-04-13" version="1">MAKQHFKKMSSRSRAWMVAGTVGLVEALKDQGFARWNFLISITTAASSDASSSSSSMCPPMSAKLDPSISVRSKALPGDPSSDPNHQKMEKLTVKLGASYHPHLLQKRLKILNHPPGLHLCHFYLLLRVAYIGWKQPTKIDKRNGQNTSLLIPGAGPITRSLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3Y9</accession>
    <name>A0A103Y3Y9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3Y9"/>
    <dbReference type="STRING" id="59895.A0A103Y3Y9"/>
    <dbReference type="Gramene" id="KVI02084">
        <property type="protein sequence ID" value="KVI02084"/>
        <property type="gene ID" value="Ccrd_019652"/>
    </dbReference>
    <dbReference type="OMA" id="HIEGVKC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119366" evidence="10">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="37600" checksum="010FFA4B9CDEAC06" modified="2016-04-13" version="1">MGSKSSIVFPTFIFIFIVIAQAEVFDITKFGAKPDAEISKLPLNYHGSSMGFLFQALCDAWSAACSATTPSKLLIPSGTFCLNVVEFKGPCKAPITVKIDGTLKGPEDPAVIPKGVQWITFSYVSALTITDSKMFHVNVMSCKNVTFDNFHICAPSESPNTDGIHLGWSKQITIKNSVIQTGDDCISIGDGCEELHIEGVKCGPGHGISVGSLGKNSGEKPVIGVYVVNCTFNQTMNGVRIKTWPDSHQGEVADLHFENLCMNQVENPIIKPSLVKVHDIFIKNVTGTATLPAVVNLKCSTANNGCENVKISDINLTYEGKEGPAFQECCNVKPVYSGKMIPPACSTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4M1</accession>
    <name>A0A103Y4M1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4M1"/>
    <dbReference type="STRING" id="59895.A0A103Y4M1"/>
    <dbReference type="Gramene" id="KVI02434">
        <property type="protein sequence ID" value="KVI02434"/>
        <property type="gene ID" value="Ccrd_019192"/>
    </dbReference>
    <dbReference type="OMA" id="HNGACCE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="417"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="652" mass="72318" checksum="DD5A18403CD95E32" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5K5</accession>
    <name>A0A103Y5K5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex with RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002618">
        <property type="protein sequence ID" value="KVI02904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5K5"/>
    <dbReference type="STRING" id="59895.A0A103Y5K5"/>
    <dbReference type="Gramene" id="KVI02904">
        <property type="protein sequence ID" value="KVI02904"/>
        <property type="gene ID" value="Ccrd_018805"/>
    </dbReference>
    <dbReference type="OMA" id="VICASKA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001661">
        <property type="entry name" value="RAD17 checkpoint clamp loader component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="101"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="532" mass="59751" checksum="A6FA660442227D64" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7I0</accession>
    <name>A0A103Y7I0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002320">
        <property type="protein sequence ID" value="KVI03925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7I0"/>
    <dbReference type="STRING" id="59895.A0A103Y7I0"/>
    <dbReference type="Gramene" id="KVI03925">
        <property type="protein sequence ID" value="KVI03925"/>
        <property type="gene ID" value="Ccrd_017771"/>
    </dbReference>
    <dbReference type="OMA" id="TGANRSM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF868_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31972:SF4">
        <property type="entry name" value="DUF868 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31972">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05910">
        <property type="entry name" value="DUF868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="33345" checksum="89C1E58AD9D9DF98" modified="2016-04-13" version="1">MRDFPSCFGENGVQVSDASSSGPPPPPPATATATAQNLVTCVYQCKLRSSSSFIVTVTWAKTLMGQNLSVEINNPTNHSLCKLEIKPWLFSKKRGYRNLEMGSNSIDFFWDLSSAKFGSSPEPVEAFYFAITVNRELILLLGDMEKEVHKKMNNNGFNSSSSPNPIFISKKEHIFGKKSYATTAQFCGKGQIHDILIECDTINTNDPFLLIRVDGKTVMQVKQLRWKFRGNYTILVDGLPVEVYWDVYSWFFGRLIGGNGVFMFQTCLSAEKLWGSAINWSNSLIKDSAYSFCTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7J8</accession>
    <name>A0A103Y7J8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002319">
        <property type="protein sequence ID" value="KVI03967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7J8"/>
    <dbReference type="Gramene" id="KVI03967">
        <property type="protein sequence ID" value="KVI03967"/>
        <property type="gene ID" value="Ccrd_017710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="24" mass="2696" checksum="A8908F7D20EE5B57" modified="2016-04-13" version="1" fragment="single">MELLAKDVAETPSCERVIYVFPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8M7</accession>
    <name>A0A103Y8M7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_017141</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002005">
        <property type="protein sequence ID" value="KVI04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8M7"/>
    <dbReference type="STRING" id="59895.A0A103Y8M7"/>
    <dbReference type="Gramene" id="KVI04541">
        <property type="protein sequence ID" value="KVI04541"/>
        <property type="gene ID" value="Ccrd_017141"/>
    </dbReference>
    <dbReference type="OMA" id="IDTIPNW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF98">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119492" evidence="12">
        <location>
            <begin position="28"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="412"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118440" checksum="AC93A04F31ECAB80" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAE8</accession>
    <name>A0A103YAE8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAE8"/>
    <dbReference type="STRING" id="59895.A0A103YAE8"/>
    <dbReference type="Gramene" id="KVI05466">
        <property type="protein sequence ID" value="KVI05466"/>
        <property type="gene ID" value="Ccrd_016245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF72">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17109" checksum="AA6F7DC01815D828" modified="2016-04-13" version="1">MALQPKIIACGNSVASFAMAVRFLTGPAVMAAASIAVGLRGTLLHVAIVQAALPQGIVPFVFAKEYNVHPAILSTAYVSFKLTGYFRDVDCVTDNASVLHHYGVVRLKMNLKVRIDGDLNGIFERQMDDASPKISFNRVDDDVQGMREGDKQEEIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEV5</accession>
    <name>A0A103YEV5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001486">
        <property type="protein sequence ID" value="KVI07807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEV5"/>
    <dbReference type="STRING" id="59895.A0A103YEV5"/>
    <dbReference type="Gramene" id="KVI07807">
        <property type="protein sequence ID" value="KVI07807"/>
        <property type="gene ID" value="Ccrd_013830"/>
    </dbReference>
    <dbReference type="OMA" id="MIITRKE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF228">
        <property type="entry name" value="IQ MOTIF, EF-HAND BINDING, P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="601" mass="65836" checksum="22586A9BBCC5203A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG86</accession>
    <name>A0A103YG86_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001109">
        <property type="protein sequence ID" value="KVI08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG86"/>
    <dbReference type="STRING" id="59895.A0A103YG86"/>
    <dbReference type="Gramene" id="KVI08529">
        <property type="protein sequence ID" value="KVI08529"/>
        <property type="gene ID" value="Ccrd_013106"/>
    </dbReference>
    <dbReference type="OMA" id="GGFCFSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="78" mass="8721" checksum="C0D5267AF98B37D9" modified="2016-04-13" version="1">MYYNLYTRLAREAGAIVVSTYLRLAPEHRLPAAVDDAYYTPPFSGFKTWQTVKPTNHGCHLRETLSVFSSLETAPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGA7</accession>
    <name>A0A103YGA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase/chloride channel, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001104">
        <property type="protein sequence ID" value="KVI08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGA7"/>
    <dbReference type="STRING" id="59895.A0A103YGA7"/>
    <dbReference type="Gramene" id="KVI08585">
        <property type="protein sequence ID" value="KVI08585"/>
        <property type="gene ID" value="Ccrd_013045"/>
    </dbReference>
    <dbReference type="OMA" id="KVNPMGY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000017">
        <property type="entry name" value="Maleylacetoacetate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF18">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="228" mass="25463" checksum="CF3FF5D036257004" modified="2016-04-13" version="1">MKNESHNQFWRVDLESSIGGSTSMEGSKAEEGNQTMKLYSHWMSSCSRRVRLALHLKGLKYDCINITSVGDPELLKVNPMGYVPALVDDTTVISDSYAILLVASIVSSSIQPLQNTSLVNYIGEIVSPDEKIPWAQYHIRKGFVALEKLLTNYAGKYATGDEVYLADLYLAPQLDNAINRYKLDMTEFPLLSKLNKAYSELPSFQQMLAETQNLDADKIFGLVKKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI58</accession>
    <name>A0A103YI58_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001057">
        <property type="protein sequence ID" value="KVI09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI58"/>
    <dbReference type="STRING" id="59895.A0A103YI58"/>
    <dbReference type="Gramene" id="KVI09534">
        <property type="protein sequence ID" value="KVI09534"/>
        <property type="gene ID" value="Ccrd_012073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF9">
        <property type="entry name" value="PREMNASPIRODIENE OXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="939" mass="106924" checksum="604A54778AE449B5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI80</accession>
    <name>A0A103YI80_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012041</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001054">
        <property type="protein sequence ID" value="KVI09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI80"/>
    <dbReference type="STRING" id="59895.A0A103YI80"/>
    <dbReference type="Gramene" id="KVI09574">
        <property type="protein sequence ID" value="KVI09574"/>
        <property type="gene ID" value="Ccrd_012041"/>
    </dbReference>
    <dbReference type="OMA" id="GCYRKAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000135">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FAD synthase middle" evidence="14">
        <location>
            <begin position="398"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="472" mass="52690" checksum="D0389FCB5E09AE87" modified="2016-04-13" version="1">MEIDKAIRESDDRRLKAKYNNAIYVIQRALALYSIEEVAFSFNGGKDSTVLLHLLRAGHFLHQVEYGHSNGDLSDREFTFPIRTIYFESPSAFPEISSFTYETADSYGVQLDILRQDFKSGLEALLKAKPIRAIFLGVRIGDPTAVGQEQFSPSSSGWPPFMRVNPILDWSYRDVWAFLLTCKVQYCGLYDQGYTSIGSIHDTVPNALLCIKDSAVGKQKFRPAYMLSDGRLERAGRARKSSLIAGRVPAVSNGLKCVEPNQSSLSFGIIEDQLGPSLCRKLHSIGWLVSQIAIVQNDVDSVAEEVERRKSMSDMVPDEEYKEYLSQLFGDKYTGDHNEMARLPEGITELLQHEKLPVPLIMCHNVIVLSATNVDELDVQWDALIDSRSTSLLTSLGPFVSKHLTTSLTDIEVAQPLSKISVEFPDIYIGCYRKSRTGPLAITFEGKDQEKVEAAMEAISLKLSSVVKQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI98</accession>
    <name>A0A103YI98_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI98"/>
    <dbReference type="Gramene" id="KVI09629">
        <property type="protein sequence ID" value="KVI09629"/>
        <property type="gene ID" value="Ccrd_011980"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1694403at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="11376" checksum="906F1DDC4F3DD8BC" modified="2016-04-13" version="1">MTQRSATVTYASIKQPGVCNNARKKLIAKSKKAMSRHSSSRQTVEAAPPRLIRVDRRASLEKKLPTIKEDECSSGDQLQSFNGNRTVSSSAKTLYSTKHHACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIQ0</accession>
    <name>A0A103YIQ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta(3)-Delta(2)-enoyl-CoA isomerase</fullName>
            <ecNumber evidence="5">5.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_011798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001042">
        <property type="protein sequence ID" value="KVI09790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIQ0"/>
    <dbReference type="STRING" id="59895.A0A103YIQ0"/>
    <dbReference type="Gramene" id="KVI09790">
        <property type="protein sequence ID" value="KVI09790"/>
        <property type="gene ID" value="Ccrd_011798"/>
    </dbReference>
    <dbReference type="OMA" id="MPFTVGM"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF84">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="240" mass="26653" checksum="16404ACA4A5347D1" modified="2016-04-13" version="1">MCTLEKRDNIYILTLTGDDDHRLNPKLLDSIRAAVNRVRSETTTPSVFITTAQGKFFSNGYDLAWSQSDPERHILMSSKLRLLVRDIISLPMPTIAAVSGHASAGGFILAQAHDYVLMRKDRGFLYMSEMDIKLVVPDWFVKLLKNKIGSPAALRDVVLRADKVTAEAAVAKGIIYSAHDSAEETVKAAVRLGEELVMRKWDGHVYGRNRKVLLADVLPALEFDETVEDVATANIVSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIQ5</accession>
    <name>A0A103YIQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_011852</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIQ5"/>
    <dbReference type="STRING" id="59895.A0A103YIQ5"/>
    <dbReference type="Gramene" id="KVI09772">
        <property type="protein sequence ID" value="KVI09772"/>
        <property type="gene ID" value="Ccrd_011852"/>
    </dbReference>
    <dbReference type="OMA" id="SKTGCEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985">
        <property type="entry name" value="OS07G0668900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985:SF23">
        <property type="entry name" value="OS07G0695300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="113"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="398" mass="43952" checksum="50C9AF7F960F5A48" modified="2016-04-13" version="1" fragment="single">SLSLSLNIFNSLSPPPPLSLSLKRVKSVCFGEGKQIQMGCLFCSEKSKKKPKFQQNKKPEDQISSTSACLFSDKLKINSALGINKEGLKDGGSTHIAAHTFTFRELAAAAKNFRADCLLGEGGFGRVYRGRLESTNQVVAIKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYYLPPDKQQLDWNTRMKIAAGAAKGLEYLHDKASPPVIYRDLKCSNILLDEDYNPKLSDFGLAKLGPVGDKTHVSTRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIDHSKTGCEHNLARPLFKDRRKFGQMADPMLQGQYPVRGLYQALAVAAMCVQEQPNMRPVIADVVTALTYLASQRYDPRAYQPQTVRTGSGSSTPRTRRNSDAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJI2</accession>
    <name>A0A103YJI2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_011449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJI2"/>
    <dbReference type="STRING" id="59895.A0A103YJI2"/>
    <dbReference type="Gramene" id="KVI10208">
        <property type="protein sequence ID" value="KVI10208"/>
        <property type="gene ID" value="Ccrd_011449"/>
    </dbReference>
    <dbReference type="OMA" id="LTDCMVL"/>
    <dbReference type="OrthoDB" id="677896at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="553"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="364"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="630" mass="68664" checksum="5AD1546B22C2F994" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKY3</accession>
    <name>A0A103YKY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_010551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000938">
        <property type="protein sequence ID" value="KVI11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKY3"/>
    <dbReference type="STRING" id="59895.A0A103YKY3"/>
    <dbReference type="Gramene" id="KVI11045">
        <property type="protein sequence ID" value="KVI11045"/>
        <property type="gene ID" value="Ccrd_010551"/>
    </dbReference>
    <dbReference type="OMA" id="MYPGKHA"/>
    <dbReference type="OrthoDB" id="1878267at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044797">
        <property type="entry name" value="At4g06598-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835:SF3">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46835">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER (BZIP) TRANSCRIPTION FACTOR FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="373" mass="41967" checksum="533683318E296601" modified="2016-04-13" version="1">MANSKGPSTMRSMMYNGKHSLLPPKSPFPSIAPSYADYVSNSAIGPKGPPKYRDGNSLHQRTSSESFLIEEQPSWLDDLLNEPETPVRRGHRRSSSDSFTYMEAANAANNEYRAQDEYRLRNLSSALSWGSQDFDIFTDSRNPSFYAEPNAMMKNKNRAWDSSQNALTHSIGSASPRDNFVLQNSISLAASREVDGNTSIATEKKDAIESLRQDADTSERKDSSSNKASASETDTKRAKQQFAQRSRVRKLQYIAELEKNVQALQAEGSEVSAEVEFLNQQSLILSMENKALKQRLETLAQEQLIKYMEHEVLEREIGRLRALYQQQQQPQQPPTAPRHRRTTSMDKLDSRFADLSLKKDSGSSHDVSGPLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS73</accession>
    <name>A0A118JS73_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_024185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005457">
        <property type="protein sequence ID" value="KVH88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS73"/>
    <dbReference type="STRING" id="59895.A0A118JS73"/>
    <dbReference type="Gramene" id="KVH88302">
        <property type="protein sequence ID" value="KVH88302"/>
        <property type="gene ID" value="Ccrd_024185"/>
    </dbReference>
    <dbReference type="OMA" id="RWPPGAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053223">
        <property type="entry name" value="Prob_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067:SF5">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="374" mass="41396" checksum="345BB4F20E1F80B5" modified="2016-04-13" version="1">MGFTMGLNLLLLVAMVATNILSLYHLSTTMISTKPTTPLNPPVPDHLLRQLQTIRATINHLTRLQPNPSLHNNPSTAAAIIPSDLLLYTQLSPIASACRHHPDLLHQYMNYTPFTLCPPPSSAAAEPLILRGCHPLPRRRCFSPTPNKLPTSLPTNPFSPVPENSILWSNYKCKNLDCLNPDLGFDLKKEKSKFLSYKTDLDLPISQLTEIAKKSKSVLRLALDIGGGTGTFAAQMKQENVTVLTTTMSLSAPYNEVAALRGLVPLHAPLQQRLPVFDGVLDLVRCGHAVNRWIPVAAMEFLLYDVDRVLRGGGYFWVDHFFSKEVDLDKIYGPLIGKLGYKKVKWAVGKKMDSSGVKNGEVYLTALLQKPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSY9</accession>
    <name>A0A118JSY9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of 2 alpha and 2 beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01005322">
        <property type="protein sequence ID" value="KVH88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSY9"/>
    <dbReference type="STRING" id="59895.A0A118JSY9"/>
    <dbReference type="Gramene" id="KVH88989">
        <property type="protein sequence ID" value="KVH88989"/>
        <property type="gene ID" value="Ccrd_009021"/>
    </dbReference>
    <dbReference type="OMA" id="ETYRWRE"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="91"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="47380" checksum="593AFD5EA124F6BA" modified="2016-04-13" version="1">MAFSGSKIIQQPLPLHTTIRSPDNPLLSDPFTAAPFLGSTRTLRLTHSISASQRRSASPIVAVSDVFKEKKLKSNTDLLLTKEEGLQVYEDMILGRAFEDMCAQMYYRGKMFGFVHLYNGQEAVSSGFIKLLKKEDSVVSTYRDHVHALSKGVPARAVMSELFGKKTGCCRGQGGSMHMFSAEHNVLGGFAFIGEGIPVATGAAFASKYRREVLKEADCDHVTLAFFGDGTCNNGQFFECLNMAALWKLPIIFVVENNLWAIGMSHLRSTSDPEIWKKGPAFGMPGVHVDGMDVLKVREVAKEAIGRARRGEGPTLVECETYRFRGHSLADPDELRDPAEKARYAARDPITALKKYLIESKLVNEAELKAIEKKIDELVEDAVEFADESPAPSRSQLLENVFADPRGFGIGPDGSYRCEDPKFTQGTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTG6</accession>
    <name>A0A118JTG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTG6"/>
    <dbReference type="Gramene" id="KVH90759">
        <property type="protein sequence ID" value="KVH90759"/>
        <property type="gene ID" value="Ccrd_007221"/>
    </dbReference>
    <dbReference type="OMA" id="KNSACAL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF108">
        <property type="entry name" value="PROTEIN ENHANCED DISEASE RESISTANCE 2 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="162"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="38734" checksum="9368F2BBF5F9C58C" modified="2016-04-13" version="1">MRIPPGLSQFYCLEATMNVEAQRKEDIMGALDKAPSSLSIRGEKEEESDDYYSYSDSVEDTRSENSWSDLSPQKHEAKLLVGHVSGSSSSQVLACCYVSEKIAWFNSSILVSRIGCGLQSVHTAVQKRGVAPLEDIEWQDSFLSNNDSSFPNDPTGDLPNSWGAAESSSFQIRGETYLQDRKKITGKGTLMQLVAANMLRSTKKQDDFAGRPGSICQKFAAANCPDFFFIVNMQIPGPTTNFHIAFYYATTTPIKDVPLLQSFVEGDDAYRNARFKLIPHVSKGPWIVKQSVGNRPCLLGQVLKIHYARGKNYLELDVDVGSSMIAKKVANTVLSTFSHLIVEAAFLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU56</accession>
    <name>A0A118JU56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_006496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004947">
        <property type="protein sequence ID" value="KVH91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JU56"/>
    <dbReference type="Gramene" id="KVH91481">
        <property type="protein sequence ID" value="KVH91481"/>
        <property type="gene ID" value="Ccrd_006496"/>
    </dbReference>
    <dbReference type="OMA" id="SNEWGLF"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000175">
        <property type="entry name" value="Inorganic phosphate transporter 1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="535" mass="58357" checksum="95D7756ED59EBF2F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV18</accession>
    <name>A0A118JV18_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FLX-like 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FLX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV18"/>
    <dbReference type="STRING" id="59895.A0A118JV18"/>
    <dbReference type="Gramene" id="KVH92964">
        <property type="protein sequence ID" value="KVH92964"/>
        <property type="gene ID" value="Ccrd_005006"/>
    </dbReference>
    <dbReference type="OMA" id="EKPRMTR"/>
    <dbReference type="OrthoDB" id="2018286at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040353">
        <property type="entry name" value="FLX/FLX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405">
        <property type="entry name" value="PROTEIN FLX-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405:SF20">
        <property type="entry name" value="PROTEIN FLX-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31434" checksum="457F76CB4D297F2F" modified="2016-04-13" version="1">MAGRSRYPREAYDNRRGHLPGGPPSLGHMSRPMPPHPAMLEEELEMQHHEIRRLLGENRRLAEDRIALQQELGAAREELRRMNIAIADIQAEQEIHSRQLIENGLKLEADLRATEPLKNEAAQLHAEVERLNSLRHDLSAQVQILKRDLAKLQADNKQLPALRAEHEGLHQELMHARAAIDYERKGGMELMEQRQAMEKNLVSMAREVEKLRAELTNTDVRPWGAGGSYGMKFGNSDARFPPAYGDGYGVHLGAAEKGPPYGSSSATRAGLEKSRMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWE7</accession>
    <name>A0A118JWE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWE7"/>
    <dbReference type="STRING" id="59895.A0A118JWE7"/>
    <dbReference type="Gramene" id="KVH94462">
        <property type="protein sequence ID" value="KVH94462"/>
        <property type="gene ID" value="Ccrd_003501"/>
    </dbReference>
    <dbReference type="OMA" id="LIPCWLR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="282" mass="30577" checksum="C8CB490FDBC03CE6" modified="2016-04-13" version="1">MPEGIKNGLSFKKSSNNTGEMGVKDIQNWWTSPSKVASHFGTSGAAVAAATGITHPLDVLKVRLQMQFVGERGPLSGMGQTFVRVVRKEGPRSLYLGLTPALTRSVLYGGLRLGLYEPSKHFCELAFESTNIFMKIASGAASGAFATLLTNPVEVRLQMNHNVHGGAIGELRKIAAKEGIAALWKGVLRKWTSLEEGFYLHLSSSTVAGSVSTLITAPMDMVKTRLMLQQESVRDGAYKNGFHCAYKVTCYGFAIFARLGPQTTITFILCEKMRELAGLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX94</accession>
    <name>A0A118JX94_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX94"/>
    <dbReference type="STRING" id="59895.A0A118JX94"/>
    <dbReference type="Gramene" id="KVH95712">
        <property type="protein sequence ID" value="KVH95712"/>
        <property type="gene ID" value="Ccrd_002173"/>
    </dbReference>
    <dbReference type="OMA" id="SAFIRCE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010197">
        <property type="term" value="P:polar nucleus fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22005">
        <property type="entry name" value="HMG-box_AtHMGB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47658">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47658:SF1">
        <property type="entry name" value="MEIOSIS INITIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="25722" checksum="C6E3F27426643ABC" modified="2016-04-13" version="1">MGRSGDATSKSVNATRARKRVEADTASTSLKRAKNGSAFTRCEACNKDVAVALISMHDCGLDAKIRMNLEAQVVEMLNDPVVKKATEKKKPSTGKEQSAKKVKKQKDPSKPKKPPTAFFLFMEEFRVTFKAANPDNKKVSVVAKEGGEKWRSMTEEVSSKFLDLFVLEKKPYTERAAELKEDYLNALQTPIDAENEKAERESNDDDDEGDKVEVVADEEGSPDEVEVVADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXC0</accession>
    <name>A0A118JXC0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004221">
        <property type="protein sequence ID" value="KVH96746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXC0"/>
    <dbReference type="Gramene" id="KVH96746">
        <property type="protein sequence ID" value="KVH96746"/>
        <property type="gene ID" value="Ccrd_001160"/>
    </dbReference>
    <dbReference type="OMA" id="NYPLHWL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF7">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="6">
        <location>
            <begin position="198"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="587" mass="66205" checksum="1907BA40E7F89A99" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY05</accession>
    <name>A0A118JY05_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY05"/>
    <dbReference type="STRING" id="59895.A0A118JY05"/>
    <dbReference type="Gramene" id="KVH97256">
        <property type="protein sequence ID" value="KVH97256"/>
        <property type="gene ID" value="Ccrd_000631"/>
    </dbReference>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH97256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="340" mass="36168" checksum="600B5D8527CFB563" modified="2016-04-13" version="1">MAALCNRFSKACATITNRHFKISTYVRSMSNVPENTVYGGPKPQNPDQRVTLTSLRTKHRKGEAITMVTAYDYPSAVHLDTAGIDIALVGDSASMVVHGHDTTLPITLDEMLMHCRSVARGAKRPLLAVDTAVRVLKEGGMDAIKLEGGAPSRISAAKHIVEAGIAVMGHVGLTPQAISVLGGFRPQGRNVLSAVKVVETALALQEAGCFSVVLECVPAPVAAAATSVLRIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQFAQVGEVINKALSDYKQEVENRSFPGALHSPYKINTTEVDGFLKELQKMGLDEAAAAAAEAAEKVEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY15</accession>
    <name>A0A118JY15_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01003840">
        <property type="protein sequence ID" value="KVH97301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY15"/>
    <dbReference type="STRING" id="59895.A0A118JY15"/>
    <dbReference type="Gramene" id="KVH97301">
        <property type="protein sequence ID" value="KVH97301"/>
        <property type="gene ID" value="Ccrd_000592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="456" mass="50717" checksum="292F0A4C12373AAE" modified="2016-04-13" version="1">MNSGGGLVSGSSDSGRGFLVPGKMETCIYNNGLIEAGAAMEVDYVEKDPRGRYIRYPEILGKGTFKKVYGFFSFHTFFRYKAFDRLDGIEVAWNRVRIDDVLQSSDDFGKLYSEVLLLRSLKHDNVIKFFDSWIDIKKKTLNMITELFTSGSLRQEFIEKCLVPAKQRLSAMELLKDPFLDCENPKNPTQVPRALSRLNESVDTSNGGDHPVVELHRKHQENEFSLQGTKNDNNSVSLTMRIADPSSQARNIHFTFYPDRDTAPSVANEMVEQLDLVEHDATFIAEFINNLISKIIPGWKPSSAYCSHEGTKTHGTPSSKQPSSGCLSDGGTNTHDSPKSNTDPPEPTNMPVRPVLISVSEHGSLISKDSEVSLESEPGSFIGSGSSFADLNIGISKSRGLSSNGSFLSLCECGDKVKARIELEAIETRYKQWCQEMKRVREKGVEATRKRCITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY82</accession>
    <name>A0A118JY82_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY82"/>
    <dbReference type="Gramene" id="KVH98212">
        <property type="protein sequence ID" value="KVH98212"/>
        <property type="gene ID" value="Ccrd_023553"/>
    </dbReference>
    <dbReference type="OMA" id="NARIPMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080054">
        <property type="term" value="F:low-affinity nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17417">
        <property type="entry name" value="MFS_NPF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000147">
        <property type="entry name" value="Protein NRT1/ PTR family 5.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044739">
        <property type="entry name" value="NRT1/PTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111528" checksum="AE78237D5B6D21E8" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYM0</accession>
    <name>A0A118JYM0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYM0"/>
    <dbReference type="STRING" id="59895.A0A118JYM0"/>
    <dbReference type="Gramene" id="KVH98336">
        <property type="protein sequence ID" value="KVH98336"/>
        <property type="gene ID" value="Ccrd_023410"/>
    </dbReference>
    <dbReference type="OMA" id="RAFSENC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000026">
        <property type="entry name" value="Cytochrome P450 82C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF39">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58934" checksum="A7A1ABD54F8718CF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZK7</accession>
    <name>A0A118JZK7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZK7"/>
    <dbReference type="STRING" id="59895.A0A118JZK7"/>
    <dbReference type="Gramene" id="KVI00058">
        <property type="protein sequence ID" value="KVI00058"/>
        <property type="gene ID" value="Ccrd_021708"/>
    </dbReference>
    <dbReference type="OMA" id="KANIGTY"/>
    <dbReference type="OrthoDB" id="1060521at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080115">
        <property type="term" value="F:myosin XI tail binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007656">
        <property type="entry name" value="GTD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31422">
        <property type="entry name" value="BNAANNG28530D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31422:SF57">
        <property type="entry name" value="GTD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04576">
        <property type="entry name" value="Zein-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51775">
        <property type="entry name" value="GTD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GTD-binding" evidence="6">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="56446" checksum="21BE8110FF537D27" modified="2016-04-13" version="1">MESESMHPSTSLVKCCECGCRYCDATDGSYYGTWLRSVKRKVDEYDEGGGKFFIPGLLIPKVARVEIENECAVLREMVSSQQSTIQDLIADLEEERYASASAANEAMSMILKLQREKAEIEMEARQFKRFSEEKMAHDQQELMALEELLYRREQSIQSLTCEVQAYKHRMISFGLTESEADGEKSFITRNNSVATNLESQFDFPSYDYPPLKCNLNENHAYQENDNETVDIEKYAFGETPRSLKDIEERINQLERSPRHSQPVLEKVIVGHSPMKKHSRRFSSDSVGSYFATVKEDLVLDSPRVGGNTRKMEFSQTDDFPSFKKVDTVSEFGDEMSDRIYTIDSIHNGNNDPKANIGTYDDFMSSPKESSSVTGIEDPEVKKLYARLHALEADRESMRQALISMRTDKAQLVLLKEIAQHLCKEMSPASKMPVKKPSGGAGSSFFSVVKWIVTFGYWKRAQRNQHIFSAVANNAGLLMVLERGPQLGQWRCLSSTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZS0</accession>
    <name>A0A118JZS0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003391">
        <property type="protein sequence ID" value="KVI00315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZS0"/>
    <dbReference type="Gramene" id="KVI00315">
        <property type="protein sequence ID" value="KVI00315"/>
        <property type="gene ID" value="Ccrd_021453"/>
    </dbReference>
    <dbReference type="OMA" id="FVHDMDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000637">
        <property type="entry name" value="WD-40 repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF43">
        <property type="entry name" value="WD40_YVTN REPEAT-LIKE-CONTAINING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="458" mass="52204" checksum="574A26B9AACEF9CB" modified="2016-04-13" version="1">MPHHEVDQIDYMAEEGDMSDFADDVDGEENGGGDRSLDDYDMILVRLEFNPESSIRFILTKVTDTSSAQARTGKDIQGILWERLNITRESYRRTRLEQYRNYENIPLSGDAVDKVVYLRRLPKCKQKSKGGYYYEFFHNTRSVKPTILHFQLRNLVWATSKHDVYLMSNYSIMHWSSLSQNLTEILNFSGHVAPTEKHAGSLLEGFTQTQISTLAVNDDFLVAGGFQGELACKRLDKQGVSFCTRTTYEDNAITNAIEIYDTLSGGTHFMASNNDCGVREYDMERFQLVNHFHFPWPVNHTSLSPDCKLITVVGDHLDGLLTVATVEGHLDYSFASAWHPDGRIFATGNQDKTCRVWDLRNLSNPVSVLKGNMGAVRSVRFSSDGQFLVVAEPADFVHVYNTNLNYEKRQEIDFFGEISGVSLSPDDESLYIGVWDRTFASLLQFNKRHRYGYLDSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K068</accession>
    <name>A0A118K068_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
            <ecNumber evidence="6">2.7.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01003250">
        <property type="protein sequence ID" value="KVI00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K068"/>
    <dbReference type="STRING" id="59895.A0A118K068"/>
    <dbReference type="Gramene" id="KVI00798">
        <property type="protein sequence ID" value="KVI00798"/>
        <property type="gene ID" value="Ccrd_020948"/>
    </dbReference>
    <dbReference type="OMA" id="GNGTFHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17302">
        <property type="entry name" value="PIPKc_AtPIP5K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017163">
        <property type="entry name" value="PIno-4-P-5_kinase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF113">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037274">
        <property type="entry name" value="PIP5K_plant_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="9">
        <location>
            <begin position="347"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="726" mass="82300" checksum="B4F451096B587420" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0C9</accession>
    <name>A0A118K0C9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_021240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003382">
        <property type="protein sequence ID" value="KVI00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0C9"/>
    <dbReference type="STRING" id="59895.A0A118K0C9"/>
    <dbReference type="Gramene" id="KVI00510">
        <property type="protein sequence ID" value="KVI00510"/>
        <property type="gene ID" value="Ccrd_021240"/>
    </dbReference>
    <dbReference type="OMA" id="AYMSSYE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="468" mass="53571" checksum="2F1A855E8C41F025" modified="2016-04-13" version="1">MHHSSVFLRKRPSFYTTRRALASQCHDNDHARLISAKSDNQSSFSSLHLSSPSRLNIGWKSNYKKVESLLESLTSTVVVVGLSLGLCYLNSVSQPNSHMVFEYFASQRSPDGEPFMTPSDLMRAVVPVFPPSEASHIREGSLKGEWAPSELHCPPSKFFMLFDTNNDGLISFAEYIFFVTLLSIPETSFSIAFKMFDLDNNGSYSKTTNREIDKEEFKKVMALMRAQHRQGSRHRDGLRIGLKVKTHVENGGLLEYFFGKDGKSCLAHGKFTQFLKDLQNEILLLEFAHYDYKSRGTISAKDFALSMVASADMRHINKFLDRVDQLNDEPNLKNIRITFEDFKNFAKLRTQLRPLSLAIFSYGKVNGLLTKQDFHRAIEQTIYYVFDVNQDGSLSWEEFLRVLQRREEDKIQPREAGVVGLISCWLQLDDDDDDDDDDSLSTQNNWRVTCMSREDLLGNDIVIEQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1L4</accession>
    <name>A0A118K1L4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002579">
        <property type="protein sequence ID" value="KVI03060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1L4"/>
    <dbReference type="Gramene" id="KVI03060">
        <property type="protein sequence ID" value="KVI03060"/>
        <property type="gene ID" value="Ccrd_018646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="65" mass="7516" checksum="2FC3FF69AE19BB2E" modified="2016-04-13" version="1">MDRNIVKKIMGEHVIMTDVQNPNFIDQNYCSGSINCSGSVFMHENEQHVVPRRTQSIFYKNDGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1X8</accession>
    <name>A0A118K1X8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002349">
        <property type="protein sequence ID" value="KVI03466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1X8"/>
    <dbReference type="STRING" id="59895.A0A118K1X8"/>
    <dbReference type="Gramene" id="KVI03466">
        <property type="protein sequence ID" value="KVI03466"/>
        <property type="gene ID" value="Ccrd_018235"/>
    </dbReference>
    <dbReference type="OMA" id="RFCADSG"/>
    <dbReference type="OrthoDB" id="1849062at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="52464" checksum="E206E936DCCBF454" modified="2016-04-13" version="1">MAEAINDQTLSIEEEAFGTTDGNPHEEWLHSILKAKSPPSCSTQIHRVPMILREHKDHDKYYVPKVVSLGPYHHGNPNLESVQNFKPLFTNELVSGNQESLQSLYNKLEEMVQTLRGYYEEDEDDRFSDEEFTKMMMLDGCFILYFIEHIFLNNDTLGLKGHQIMFVQQDLFLLENQIPYPVLTEVMKFVPDKMWDFKIKRFIDDNILATERHRRGGQANYAKANNPIPATINHLLELLQTRVTREKSLGPRANDRYTFRNVNELIEVGIHFKPSVTRSLAHIEFSKHGFFANLQLPPITIDDATKPMLLNLVAYEMCSNDAKASWVTSYICLMDSLIDHSEDVKVLRKAGVLDNRLGSDKEVAKLFNEIGTDLVPNNFAYSEARFAIQKHYDSKRNTWISQLKHEYMKSPWAFVALFVGVVGLFLSGVQAYFSVWGLRSDCDYVCKALKERHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K230</accession>
    <name>A0A118K230_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_017979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K230"/>
    <dbReference type="STRING" id="59895.A0A118K230"/>
    <dbReference type="Gramene" id="KVI03736">
        <property type="protein sequence ID" value="KVI03736"/>
        <property type="gene ID" value="Ccrd_017979"/>
    </dbReference>
    <dbReference type="OMA" id="EARFTIW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF163">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="15">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI03736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="511" mass="57645" checksum="760B3E012F045C74" modified="2016-04-13" version="1">MDIKGNILMERYELGRLLGQGTFAKVYFARHLRTGQSVAIKVIDKDKVSRVGLINQIKREISIMRLVRHPNILLLYEVMATKTKIYFALEYAKGGELFDKVAKGKLKEHTARKYFQQLINAIDFCHSRGVYHRDLKPENLLLDENENLKVSDFGLSALAESKRQDGMLHTTCGTPAYVAPEVINRGGYDGDKADVWSCGVILYVLLAGYLPFHDSNLVEMYRKIGKSEFRIPNWFPPEVRRLLLKILDPNPISRISIAKIKENPWFQKGKIAREPRNETENKVLVPPPSSDGASGSSITDPEENQEVMNPPNMNAFDIISLSPGFDLTALFVEPRQKKEARFTIWQPASIIISKLEDVAKLLRMKVSKREAGLLKIEALDEGRKGILSIDAEIFELTPSFHLVEVKKSNGDTLEYQKVVDEGLRPGLEDIMWDWQSDEQAPPQQEQQVQPQQDQFTGDGVKRSITSTSPLEAKILVPGPSTSVATLILGLVSMLPRHIKFVSCEEFGCRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K258</accession>
    <name>A0A118K258_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinoprotein amine dehydrogenase, beta chain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K258"/>
    <dbReference type="STRING" id="59895.A0A118K258"/>
    <dbReference type="Gramene" id="KVI03840">
        <property type="protein sequence ID" value="KVI03840"/>
        <property type="gene ID" value="Ccrd_017855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="500" mass="54081" checksum="625AD6E0DD03CD18" modified="2016-04-13" version="1">MAPATSLRYLHYPPPAVYMGNMHSIDRLSLAAELPLMPVPLFCSPSYATADSRPQLQIGRRPVDSDNGQLESSDRLQVLANATELYEQMMASSVPSSSTHDTVVDSVSNPTPGEMQSSFYRNAMDVTGTTAVQPPVEYQQNGASDMDTSGAVGVPEPVPSQMGGATVEIRQDLFRDRVCWELPFMQGWLVGQSQAGTQSTFPLTGSTQEHSAGNRGPGPTTLPPESASSNGELLEASLVMPHGTNRVTLERPGLRDLSSNAASTSASEYRQNALINEPNDGGDSFPIISRIQSQLSASLTATAAAELPCTVKLRIWPHDFKNPCASLKAERCRLIIPHAVLCSEMGAHFSPCGRYLAACVACVLPQFEADPGIPNQLHQERAATSPTRHPISARQVMYELRIYSLEEATFGTVLISRPIRAAHCLTSIQVYRVSDMELVSVLPSAEDEVNVACFHPLAGGGLVYGTKEGKLRILQYDGAYVTKITRPDHLFEAQTVEVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3C8</accession>
    <name>A0A118K3C8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3C8"/>
    <dbReference type="STRING" id="59895.A0A118K3C8"/>
    <dbReference type="Gramene" id="KVI05747">
        <property type="protein sequence ID" value="KVI05747"/>
        <property type="gene ID" value="Ccrd_015938"/>
    </dbReference>
    <dbReference type="OMA" id="DYMTRNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF40">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="615" mass="68603" checksum="B4CFC227B58EF3B3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K676</accession>
    <name>A0A118K676_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K676"/>
    <dbReference type="STRING" id="59895.A0A118K676"/>
    <dbReference type="Gramene" id="KVI10258">
        <property type="protein sequence ID" value="KVI10258"/>
        <property type="gene ID" value="Ccrd_011367"/>
    </dbReference>
    <dbReference type="OMA" id="SIAMEFH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="PFYRE" evidence="3">
        <location>
            <begin position="398"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="492"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LxCxE motif" evidence="3">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="555" mass="62254" checksum="165AE81775310F31" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124P3P6</accession>
    <name>A0A124P3P6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_024258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01012286">
        <property type="protein sequence ID" value="KVD98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124P3P6"/>
    <dbReference type="Gramene" id="KVD98120">
        <property type="protein sequence ID" value="KVD98120"/>
        <property type="gene ID" value="Ccrd_024258"/>
    </dbReference>
    <dbReference type="OMA" id="PIMGAYR"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF349">
        <property type="entry name" value="CYTOCHROME P450 716A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVD98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="409" mass="46841" checksum="E7F61DD1532A82EB" modified="2016-04-13" version="1">MDIFYASLLSLFVLVVSFSLHFFIYKLKTTEDGRVLPPGRTGWPIIGESFEFLATGWKGHPEKFIFDRMSKFSPIVFRTSLMLEDAAVFCGAQGNKFLFSNENKLVQGWWPASVDKIFPSSDKTSKIEAIKMRKMLPNFFKPEALHRYVPIMDVVTQQHFANGWEGKDEVVTYELTKNFTFWLACKIFVSIDDPERVRYLSGPFESIALGLLSIPINLPRTPFRRGINAANFIRKELIAIVKQRKIDLAQGKATPTQDILSHMLLFSDEDGKFMGEYDIADKILGLLIGGHDTASSACAFLVKYLAELPEIYDGVYKEQMEIAKSKAPGELLTWEDLSKMKYSWNVACEVLRLAPPLQGAFREAITDFMYNGYSIPKGWKVIYTLHNVYKRTSFRNQKYIRNRGNKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RFJ2</accession>
    <name>A0A124RFJ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007598">
        <property type="protein sequence ID" value="KVG80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RFJ2"/>
    <dbReference type="STRING" id="59895.A0A124RFJ2"/>
    <dbReference type="Gramene" id="KVG80511">
        <property type="protein sequence ID" value="KVG80511"/>
        <property type="gene ID" value="Ccrd_026190"/>
    </dbReference>
    <dbReference type="OMA" id="MRIACYG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12175">
        <property type="entry name" value="2-Hacid_dh_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF25">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="254"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="50720" checksum="D15D26413412C64B" modified="2016-04-13" version="1">MLFRFYNSLNLNILRRQSPCKDTRLKSFFGLFWDINKRNMCEDGKANTRILFCGPHFAASHNYTKEYLQNCPSIQVDDLPFASIPDLIGNYDICVVKSMRLNSDVIARATRMKLIMQYGVGLEGIDIAAATNHGLKVARIPSGETGNAASCAEMAIYIMLGLLRKQVGSHTNLLTNTFINLHFHNEMQFAVKQKKLGEPIGDTLLGKTVSSINYSPVLLNLGDKVGELDELLAALHYVIILCNKQSWALCSNLTLELDGHSKEVFILGFGNIGIELAKRLRPFGVRILATKRNWSSSVPGGFNSTEPTYQNGTHEDLVDEKGSHEDIYEFAKISDIVVCCLTMNNITAGVINKNFLSSMRKGGLLVNIARGGLLDYEAVYNSLKSGHLGGLGIDVAWTEPFDPDDPILKFPNVLLTPHVAGVTECSYRFMAKVCILDIVVGDVAIQLQSGKPLTGIELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAI6</accession>
    <name>A0A124SAI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_025106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006008">
        <property type="protein sequence ID" value="KVH87610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAI6"/>
    <dbReference type="STRING" id="59895.A0A124SAI6"/>
    <dbReference type="Gramene" id="KVH87610">
        <property type="protein sequence ID" value="KVH87610"/>
        <property type="gene ID" value="Ccrd_025106"/>
    </dbReference>
    <dbReference type="OMA" id="NHGKIYC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000004">
        <property type="entry name" value="DNA cross-link repair 1A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000027">
        <property type="entry name" value="DNA ligase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="743" mass="83464" checksum="512FA030CD327DE0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAJ9</accession>
    <name>A0A124SAJ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005880">
        <property type="protein sequence ID" value="KVH87731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAJ9"/>
    <dbReference type="STRING" id="59895.A0A124SAJ9"/>
    <dbReference type="Gramene" id="KVH87731">
        <property type="protein sequence ID" value="KVH87731"/>
        <property type="gene ID" value="Ccrd_024984"/>
    </dbReference>
    <dbReference type="OMA" id="TEREGCK"/>
    <dbReference type="OrthoDB" id="1926344at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF227">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="86"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20704" checksum="D26EA171F37CB125" modified="2016-04-13" version="1">MNMEDGLNLTLGLPGRGEEESTVSCFKNNNKRSQPETNDDCNESNQAKEGDMETSPAAKSQVVGWPPVRKYRRNSFQPKKTEAESGMYVKVSMDGAPYLRKIDLKVYKGYPQLLEALEHMFKLTIGVYSERDGYKGSEYAPTYEDKDGDWMLVGDVPWEMFMLSCKRMRIMKGSEAKGLGCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBP3</accession>
    <name>A0A124SBP3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005055">
        <property type="protein sequence ID" value="KVH91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBP3"/>
    <dbReference type="Gramene" id="KVH91287">
        <property type="protein sequence ID" value="KVH91287"/>
        <property type="gene ID" value="Ccrd_006692"/>
    </dbReference>
    <dbReference type="OMA" id="QIFEVIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="13223" checksum="A404AB2FC2EEC5EE" modified="2016-04-13" version="1">MGDNNLNSDIFVYTILVNGASRCRRLDIARDVFSYLSAKGLQPDVRTYNAMINGFCREGLMSEAKDLFLVMEERGCLPNSVTFNVLLQGFLKSQLHDEVEKLLLQMKERGFSHDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBQ5</accession>
    <name>A0A124SBQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005042">
        <property type="protein sequence ID" value="KVH91376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBQ5"/>
    <dbReference type="Gramene" id="KVH91376">
        <property type="protein sequence ID" value="KVH91376"/>
        <property type="gene ID" value="Ccrd_006603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="275" mass="31709" checksum="F7BE24C2E24D5B6B" modified="2016-04-13" version="1">MDTHNPSSQNPDVDHPWRLRRWGRRMAEEQLSQNGKNGLIYGMDTRIDIYNIMGAVDKVRDLMVAESWANRKSSVNGNDLTVEPSAFSSGTPKVISRSKRLGLLPDQQHLDLTGGREDRQFAFVHQAQLLFSTAERYFEKPAPLRTYLDKDSHRKIEEGMDSDDSDSNDDNEINWVEEENIWLLSCAIAIKGIIISHKLNSMRCDSNNEAHENTSSRRRSDDLYMSAIRDIKHISSSIIYRLPTDPQIYQLSLMSFYTLDLTTHIHTLDCRFPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC65</accession>
    <name>A0A124SC65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Development/cell death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC65"/>
    <dbReference type="STRING" id="59895.A0A124SC65"/>
    <dbReference type="Gramene" id="KVH92815">
        <property type="protein sequence ID" value="KVH92815"/>
        <property type="gene ID" value="Ccrd_005084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904350">
        <property type="term" value="P:regulation of protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034:SF12">
        <property type="entry name" value="B2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="15772" checksum="DE32599757648724" modified="2016-04-13" version="1">MESYWQLGDELRGQSKVSEDQKWYAAASRLAEQTRLKGERRNNLDLSKFSADTTRPRENATTFGGSNIDPTAWEDKKCKGESRFPAQVRIRIRKVCKALEEDAFRPVLHHYDGPKFRLELSIPETLDLLDLCEQNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCW5</accession>
    <name>A0A124SCW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004400">
        <property type="protein sequence ID" value="KVH95080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCW5"/>
    <dbReference type="STRING" id="59895.A0A124SCW5"/>
    <dbReference type="Gramene" id="KVH95080">
        <property type="protein sequence ID" value="KVH95080"/>
        <property type="gene ID" value="Ccrd_002863"/>
    </dbReference>
    <dbReference type="OMA" id="LGHCCIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="130"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="40742" checksum="2D4B2CE921436964" modified="2016-04-13" version="1" fragment="single">TASIRDQIYCRAQTIVPGCAVCLRDCTLVFLLTTCLSAVAGGSRTPAGRHPPFLTTPIAILTMSTSPSTAGASAPSSSSNCAKTTTKDADALRQNRILSSKLYFDVPLYKAPVIYSTSYDIAFLGIEKLHPFDSSKWGRICQFLIANGVLDKTRIVEPLEATKDDLLVVHSEAYLRSLKSSLNVSIITEVGGTILAAKLAKERGCAINVGGGFHHCSADRGGGFCAYADISLCIHYAFIRLNISRVMIIDLDAHQGNGHEKDFSDDRRVYILDMYNPYIYPLDYEARRYIDQRVEVPVAEHAFDPELVIYNAGTDILDGDPLGRLRISPDGVTIRDEKVFRFVRDKNIPLVMLTSGSTTFFRNILFLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD27</accession>
    <name>A0A124SD27_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_002339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD27"/>
    <dbReference type="STRING" id="59895.A0A124SD27"/>
    <dbReference type="Gramene" id="KVH95617">
        <property type="protein sequence ID" value="KVH95617"/>
        <property type="gene ID" value="Ccrd_002339"/>
    </dbReference>
    <dbReference type="OMA" id="SLPMEDM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000498">
        <property type="entry name" value="U-box domain-containing protein 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF132">
        <property type="entry name" value="KINASE WITH ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="436"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH95617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="722" mass="81404" checksum="C03A746451CAF7C8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFM6</accession>
    <name>A0A124SFM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FLX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFM6"/>
    <dbReference type="STRING" id="59895.A0A124SFM6"/>
    <dbReference type="Gramene" id="KVI03718">
        <property type="protein sequence ID" value="KVI03718"/>
        <property type="gene ID" value="Ccrd_017999"/>
    </dbReference>
    <dbReference type="OMA" id="RKADVCN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040353">
        <property type="entry name" value="FLX/FLX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405:SF26">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405">
        <property type="entry name" value="PROTEIN FLX-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="26046" checksum="847DD0AA2D91E291" modified="2016-04-13" version="1" fragment="single">MEGRNYIPPSLLLPRQGLQPLTVSSAPARYVIGDRYYVQHREMQSLLIDNHRLMALHVSLQQELSAARKELRHLSSDVDKVKAERDAQLREVYERLVNLEAQVKSIDESKAELVEVQRDLQKLRSENEELDDKLNKLRRDVAKESLEWHKIPMLKAELEAMQEENQRGSQAMENYRMFMAGEIEKLKVEAVDAEKRARAAAAAEAVSIPGTGYGAGYGNRQMGYAAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI87</accession>
    <name>A0A124SI87_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_009640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01000024">
        <property type="protein sequence ID" value="KVI11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI87"/>
    <dbReference type="STRING" id="59895.A0A124SI87"/>
    <dbReference type="Gramene" id="KVI11956">
        <property type="protein sequence ID" value="KVI11956"/>
        <property type="gene ID" value="Ccrd_009640"/>
    </dbReference>
    <dbReference type="OMA" id="AYVANWT"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF400">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990605" description="Laccase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="167"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="437"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="580" mass="63966" checksum="452354CD78F8CE5F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103STF7</accession>
    <name>A0A103STF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007370">
        <property type="protein sequence ID" value="KVG94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103STF7"/>
    <dbReference type="Gramene" id="KVG94276">
        <property type="protein sequence ID" value="KVG94276"/>
        <property type="gene ID" value="Ccrd_026076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="59" mass="6952" checksum="B32B04C6B8DB06B0" modified="2016-04-13" version="1">MLFSPRCLVGHVPFLVHSAVGKMLLAKLYPSIQIRTLSFMLVVEREEMKWQKFSWNFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SXQ0</accession>
    <name>A0A103SXQ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007281">
        <property type="protein sequence ID" value="KVG99460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SXQ0"/>
    <dbReference type="STRING" id="59895.A0A103SXQ0"/>
    <dbReference type="Gramene" id="KVG99460">
        <property type="protein sequence ID" value="KVG99460"/>
        <property type="gene ID" value="Ccrd_026028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG99460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="314" mass="35635" checksum="A21EF85346D9BACE" modified="2016-04-13" version="1" fragment="single">NRLEAHVECSEAGWNRHYQPSPQGSACSHREVGIVSDQIRNEWCCRAKWLELEEYEALSTKQKWRNEAVNRKQTWYAVCRRTAFEVVAGSGDKPKIMVKYKDRRRIFSAEEISSMILMKMKGVAQTFPGSTVEKAMITVPAYFNDSQRQSTKDAAKIAGLEVLRMFNEPTAAALAYALDKRASTDGKSLYERIIPDEAVAYGTGYLAANLSDLGDEVVLARELTTGRNKAIKITDGGGLSKAEIAKMIKDVERYKQEDEAHIKKAMAHKALNDYAYRLRVNLNRYKMRLSLIMDMGLSVKDLEEIEYEINETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UWC0</accession>
    <name>A0A103UWC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006848">
        <property type="protein sequence ID" value="KVH42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UWC0"/>
    <dbReference type="Gramene" id="KVH42991">
        <property type="protein sequence ID" value="KVH42991"/>
        <property type="gene ID" value="Ccrd_025751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="53812" checksum="061D5256055A4740" modified="2016-04-13" version="1" fragment="single">WIFDSTKVAGRFEKRGDCGSFDSSHDVVGDNDGNCRDGWDVGVGDGNCRGRGGGDDGDGARDGDGGVGTGRDEGAGEGGSAIRGGDDGDGDGDGDDDGDGDGDGDGDGASVGGDDGDGDGNGGFVGGDDGDVGGEIGIVGGGTTGGGENAGGGWLHVKALQFDGRERNNLHCEFDLWSGLPPKQFFLSLKSATTFKSSKLTISSILTGNSPFILLSLKSNTVKFFNFPIVSGIQASSPLSLSTNSFNVLDIFMTLEGTHPVNLLFARTITEAGELPMFSGMLDENLFIEILAEKFFRKLTFKFVKPNIKILEVWEFQNKLRKVFDKPRPRSYNKPRWSGRWPAKCWWLRSIPATRWVRNECSSISGVQQQSSVVAAAAAMNSRDIYNNEDDCTEDATKQPPPWLSLSISSLLKCFISIFVEEEDDCVMEHCLKTATEKERKQVEAVAKGPTTLLELRLTEEHGVDEDEELDVQMNMLIFRRRIRLLDDVVEMQPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCM9</accession>
    <name>A0A103XCM9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_024324</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01005486">
        <property type="protein sequence ID" value="KVH88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCM9"/>
    <dbReference type="Gramene" id="KVH88251">
        <property type="protein sequence ID" value="KVH88251"/>
        <property type="gene ID" value="Ccrd_024324"/>
    </dbReference>
    <dbReference type="OMA" id="CDMEGRI"/>
    <dbReference type="OrthoDB" id="619632at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000537">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF3">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118691" description="Receptor-like serine/threonine-protein kinase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="21">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="22">
        <location>
            <begin position="341"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="517"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVH88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="800" mass="90680" checksum="52F5A6357EC060A4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCY2</accession>
    <name>A0A103XCY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005414">
        <property type="protein sequence ID" value="KVH88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCY2"/>
    <dbReference type="Gramene" id="KVH88414">
        <property type="protein sequence ID" value="KVH88414"/>
        <property type="gene ID" value="Ccrd_026888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="10175" checksum="0D0D5060B89616BE" modified="2016-04-13" version="1" fragment="single">MSPKESKWPFKLNPRQISLGQFVSRIGLYLPKQLYIHGQLYLVVSRVTSHIRLTIINANEEMEDRTLIKILSTMKCPITFIHPPNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEG9</accession>
    <name>A0A103XEG9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005280">
        <property type="protein sequence ID" value="KVH89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEG9"/>
    <dbReference type="Gramene" id="KVH89254">
        <property type="protein sequence ID" value="KVH89254"/>
        <property type="gene ID" value="Ccrd_008759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049198">
        <property type="entry name" value="DUF6865"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35282">
        <property type="entry name" value="F5D14.24 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35282:SF2">
        <property type="entry name" value="F5D14.24 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21737">
        <property type="entry name" value="DUF6865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="14431" checksum="7C435C08CEB8F2B1" modified="2016-04-13" version="1">MGRISLSDTGWFMMHWQRSLNLACMHSLLLQRLLKKLASVDKMAKREVGSNVSEDLTRESLIAISYSLPDKHFPLKDLPRISNNLENVADAANIDKKEKCRAELISISYAESPDTKILPVKSKGQSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEW7</accession>
    <name>A0A103XEW7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEW7"/>
    <dbReference type="STRING" id="59895.A0A103XEW7"/>
    <dbReference type="Gramene" id="KVH89432">
        <property type="protein sequence ID" value="KVH89432"/>
        <property type="gene ID" value="Ccrd_008574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="17416" checksum="4787207D20D6E7E0" modified="2016-04-13" version="1">MDVQVSEAAQPPKKDVYSVWALPPEDVTARVKKLMVGLRSEFGGPEFEPHVTVVGAISLTEDEARDKLKKACEGLKAYNVTVEKVATGTFFYQCVFLLLHPTTEANALDGSVKSLSFPITRLALYKTDTEDKTLKSWQKVTEITLQPNYGVTATDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF72</accession>
    <name>A0A103XF72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7865 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005181">
        <property type="protein sequence ID" value="KVH89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF72"/>
    <dbReference type="STRING" id="59895.A0A103XF72"/>
    <dbReference type="Gramene" id="KVH89655">
        <property type="protein sequence ID" value="KVH89655"/>
        <property type="gene ID" value="Ccrd_008350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057187">
        <property type="entry name" value="DUF7865"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34274:SF12">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34274">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25266">
        <property type="entry name" value="DUF7865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7865" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="88" mass="9659" checksum="172853CCDA360AB9" modified="2016-04-13" version="1">MESSGFFVICLLHSLIVISCGGLIMFYLNEISIFGHGIETARKLSGSTPHDQLLIQTSHSFTRMISAIVTRVGSDEGGRGEEENREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGI9</accession>
    <name>A0A103XGI9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005106">
        <property type="protein sequence ID" value="KVH90358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGI9"/>
    <dbReference type="STRING" id="59895.A0A103XGI9"/>
    <dbReference type="Gramene" id="KVH90358">
        <property type="protein sequence ID" value="KVH90358"/>
        <property type="gene ID" value="Ccrd_007636"/>
    </dbReference>
    <dbReference type="OMA" id="TYVQLYI"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF72">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="817" mass="93066" checksum="5AD0246D4E938364" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHX4</accession>
    <name>A0A103XHX4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHX4"/>
    <dbReference type="STRING" id="59895.A0A103XHX4"/>
    <dbReference type="Gramene" id="KVH91039">
        <property type="protein sequence ID" value="KVH91039"/>
        <property type="gene ID" value="Ccrd_006980"/>
    </dbReference>
    <dbReference type="OMA" id="LLDGCHN"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000004">
        <property type="entry name" value="Pectin lyase-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118814" evidence="10">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="42193" checksum="E225BD91B43B0193" modified="2016-04-13" version="1">MVMIKHSITLLFVVFAFHYSSSTKVTYNVLKFGAKGNGLLDSRNAFLKAWGLACASTNPAIIYVPIGRYLIASAITFTGQGCKSKSITINIDGTLVAPSTNYYAIGNAQVWIKFYRVNHVTISGGTLDAQGAPLWACKSSGKITCPKGATTLGFYHSQNIVIRKLRSLNSQMFHILLYACNNAKLQGVSVSAPGLSPNTDGIHLTYSTGITILNSKISTGDDCVSIGPGNSNIWIEKVVCGPGHGISIGSLGWELEEAGVQNVTVKTTRFIGTQNGVRIKAWARRSNGFVKDVVFQHATMINVQNPILIDANYCPNNNNCPNQVSGIKISNVVYEDVHGTSATRVAVKFDCSKGKPCNGIKLKDVNLIYGGQPAASSCSYVAGIASGLLRPTSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHX5</accession>
    <name>A0A103XHX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. CMP-Sialate:CMP antiporter (TC 2.A.7.12) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005079">
        <property type="protein sequence ID" value="KVH91096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHX5"/>
    <dbReference type="Gramene" id="KVH91096">
        <property type="protein sequence ID" value="KVH91096"/>
        <property type="gene ID" value="Ccrd_006892"/>
    </dbReference>
    <dbReference type="OMA" id="IEEDMMT"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015136">
        <property type="term" value="F:sialic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118808" evidence="7">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="37631" checksum="D031BBC14ECF815F" modified="2016-04-13" version="1">MQWYVVASLLTLLTSSQGILTTLSQSNGGYKYDYATIPFLAEIFKLLVSSIFLWRECKKSPPARMTTEWKSVRLYPIPSIIYLIHNNVQFATLTYVDTSTYQIMGNLKIVTTGILFRLFLKRKLSNLQWMAIGLLAIGTTTSQVKGCGEASCDSLFSSPIQGYMLGVLSACLSALAGVYTEFLMKKNNDSLYWQNVQLYTFGAIFNMARLILDDFRGGFERGPWWERLFNGYTITTWLVVLNLGSTGLLVSWLMKYADNIVKVYSTSMAMLLTMVLSVFLFTFKPTLQLLLGIIICIMSLHMYFAPPSTLVDLPLAVKAAPQSGIEVSVNRRTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIU2</accession>
    <name>A0A103XIU2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004942">
        <property type="protein sequence ID" value="KVH91489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIU2"/>
    <dbReference type="Gramene" id="KVH91489">
        <property type="protein sequence ID" value="KVH91489"/>
        <property type="gene ID" value="Ccrd_006487"/>
    </dbReference>
    <dbReference type="OMA" id="SHEQECH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36376">
        <property type="entry name" value="OS09G0514700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36376:SF1">
        <property type="entry name" value="OS09G0514700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="50447" checksum="D58B4B2373495538" modified="2016-04-13" version="1">MSELIGVNRKISRLMDKTCLKMHCRTDSHEQECHMEKDSHVEAPGVEVPKASIRRSSRLRSKKKVSPCSQDACRSYHSSSNYTKKSLKTCLDRESSISESKIEEDNKHKIPHRNENNCLLSADTASMRSSAAGPSFKYHVRAKDGIRLLVDLNLKRSNWLKSMEKAVCVCQNHQKPGFGSFRQEVECLRDKNNLKINSPAKASASDASMNSYAQNKFSIKSMSREIGKTLPSVVEKEVTTISSLEFSTRDGYTKSSNSVVPDAPHEPASLLNMTVIGSKVRSKKGKSSELVHVNCQDTTMKENYSPNAECLEVVAFSSEENQFSDFSSHQKGSSCSRTGMICSENLLTSTFEVNQETAGNHRRSTVENRESINSAEGMEVSGRDGNTIVISASDGGRKRRKHNDKSDYIHGQSHQRILRSTKLLGGQILEQGGLVIRRSSRLLSKAVPFAGKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIZ1</accession>
    <name>A0A103XIZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004989">
        <property type="protein sequence ID" value="KVH91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIZ1"/>
    <dbReference type="STRING" id="59895.A0A103XIZ1"/>
    <dbReference type="Gramene" id="KVH91439">
        <property type="protein sequence ID" value="KVH91439"/>
        <property type="gene ID" value="Ccrd_006541"/>
    </dbReference>
    <dbReference type="OMA" id="DQGGMYV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465">
        <property type="entry name" value="CAVEOLIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118847" evidence="2">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="188" mass="21103" checksum="AA4C40415685A416" modified="2016-04-13" version="1">MPHARTQHCCFLLCLITLQVICRADRNILNVGEELQKETLPLQSGSRIYQLEGLRPRTWYEVKISYPASIPASFSLQLNKGNSDLLLKPQRKLLNTEKLIFKNDLQDDQSGTYVMLTVEPEGVVAIPHGKERELVIYNIVCDELVVGIPHKAWWVVIMAVVCLGVAFAIPSFLPLVLMSTDPTSSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ42</accession>
    <name>A0A103XJ42_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-arabinokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004933">
        <property type="protein sequence ID" value="KVH91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ42"/>
    <dbReference type="STRING" id="59895.A0A103XJ42"/>
    <dbReference type="Gramene" id="KVH91514">
        <property type="protein sequence ID" value="KVH91514"/>
        <property type="gene ID" value="Ccrd_006465"/>
    </dbReference>
    <dbReference type="OMA" id="RCMEVIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000140">
        <property type="entry name" value="L-arabinokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053205">
        <property type="entry name" value="GHMP_kinase_L-arabinokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134:SF2">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134">
        <property type="entry name" value="SLR1395 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33978" checksum="D0FE6F84CA3024C8" modified="2016-04-13" version="1">MTKKDGAEAASATGKRLVFAYYVTGHGFGHATRGVEVVRHLILAGHDVHVVTGAPDFVFTTQIQSPRLFLRKLVLDCGVVQADALTVDRLASLEKYSETAVAPRDSILATEAEWLKSIKADLVVIACLSFFTYVVPVACRAAADAGISAVCVTNFSWDFIYAEYVVVAGYHHRSIVWQIAEDYSHCQFLIRLPGYCPMPAFRDVVDVPLVVRRPQHSRKEVRRELGISEDKKVVILNFGGQTIGWNLKEEYLPPGWICLVAARILQDAAHGKNYRSDKVSGARRLRDAIVLGFQLQRAPGNDISIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJH2</accession>
    <name>A0A103XJH2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004908">
        <property type="protein sequence ID" value="KVH91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJH2"/>
    <dbReference type="STRING" id="59895.A0A103XJH2"/>
    <dbReference type="Gramene" id="KVH91739">
        <property type="protein sequence ID" value="KVH91739"/>
        <property type="gene ID" value="Ccrd_006225"/>
    </dbReference>
    <dbReference type="OMA" id="RVINEVM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF52">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="404" mass="46019" checksum="2DC04AFA9DFB6C1C" modified="2016-04-13" version="1">MWVVENWRFDFVCHLGSMGKTTRSVLGLTGKFINDFLSFLVFSVLDVLDLILCYVYKTIDFFVEAEWKPCYCSSPKQAIISSGNILVSENGEAEKIVCLTSAKLQLEEISDTLYTRPSVVLEVSKTTVKRRKVVNSTNSATVQRVQSSPFVVNNTLVELLQEKISAHKSHPVPRWSDCDCDTSFWTETLFPNFSRSIKSKYRLFAIDLLGFGKSPKPHDSLYTMKEHLDMIERSVLEPNKIESFHIVAHSLGCILALALAVKYPNSVKSLTLLAPPFFPTPKGEEAAQYMMRKVAPRRLWPLIAFGASMACWYEHVSRTICLLICKHHRTWEFLAKLITRNSINVFHGRDDELIPVECCDNIKAKVPRANVKVVEKKDHITIVVGRQQTFARELEHIWKTAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJR9</accession>
    <name>A0A103XJR9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_005974</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004889">
        <property type="protein sequence ID" value="KVH91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJR9"/>
    <dbReference type="STRING" id="59895.A0A103XJR9"/>
    <dbReference type="Gramene" id="KVH91997">
        <property type="protein sequence ID" value="KVH91997"/>
        <property type="gene ID" value="Ccrd_005974"/>
    </dbReference>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000003">
        <property type="entry name" value="Phenylalanine--tRNA ligase chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000082">
        <property type="entry name" value="Phenylalanine--tRNA ligase chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000080">
        <property type="entry name" value="phenylalanine--tRNA ligase, chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="177"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="15">
        <location>
            <begin position="334"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="48797" checksum="AF05129FFFE290FA" modified="2016-04-13" version="1">MAALTFAHNILLSNPSFLRHSTKTGFTTFFSVSSPYLRRYKSTQTLVASSVLELGGVKISKQDVVRDEPTNNVPDLIFTKLGLQLHRRDNHPLGILKNAIYEYFDTNYNNQFHKFDDLCPIVTIKENFDDVLVPADHVSRSFNDTYYIDAGTVLRCHTSAHQADLLRKGYANFLVTGDVYRRDSIDSTHYPVFHQMEGVRVFNPSDWNDSGMDGTLYAANDLKACLEGLARHLFGAVEMRWVDSYFPFTNPSFELEIYFQEKWLEVLGCGVMEQEILNRGGKTDNVAWAFGLGLERLAMVLFDIPDIRLFWSTDKRFVSQFTKGQLGIKFKPFSKYPPCYKDVSFWINDSFSENNLCEIVRGIAGDLAEEVQLIDNFTNKKGMTSHCYRITYRSMERSLTDEEINELQWNVRDQVQSQLNVVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKK2</accession>
    <name>A0A103XKK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_005469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004816">
        <property type="protein sequence ID" value="KVH92481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKK2"/>
    <dbReference type="Gramene" id="KVH92481">
        <property type="protein sequence ID" value="KVH92481"/>
        <property type="gene ID" value="Ccrd_005469"/>
    </dbReference>
    <dbReference type="OMA" id="HPCRDGE"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000722">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF47">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118871" evidence="11">
        <location>
            <begin position="26"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="468"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH92481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="788" mass="85600" checksum="9BD54B669B27B009" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKP2</accession>
    <name>A0A103XKP2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XKP2"/>
    <dbReference type="Gramene" id="KVH92473">
        <property type="protein sequence ID" value="KVH92473"/>
        <property type="gene ID" value="Ccrd_005504"/>
    </dbReference>
    <dbReference type="OMA" id="RNFQFHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1296" mass="145006" checksum="9423ED1E64489826" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM28</accession>
    <name>A0A103XM28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004787">
        <property type="protein sequence ID" value="KVH93272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM28"/>
    <dbReference type="Gramene" id="KVH93272">
        <property type="protein sequence ID" value="KVH93272"/>
        <property type="gene ID" value="Ccrd_004683"/>
    </dbReference>
    <dbReference type="OMA" id="PATVWEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20361" checksum="0F19B6C81E7F0FF3" modified="2016-04-13" version="1">MVKFDSDGKLQMLSNTFPVNKLKEMSNSWTIFNLSKLLGRGPTIMLLLTSKSVMPCSIPTSSGRQPARRLLDKRPCSKYGMCPKLLGMHPLNLLLDKTSMEAGEFPMFSGRREWKRLLFTTMASSSLSKSSGGNAPSNSLYLISRNFKEGIPKITLGKGPTKRLSLASSSNKSIRFEKLLGKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM72</accession>
    <name>A0A103XM72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5-thioribose kinase</fullName>
            <ecNumber evidence="3">2.7.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004780">
        <property type="protein sequence ID" value="KVH93318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM72"/>
    <dbReference type="STRING" id="59895.A0A103XM72"/>
    <dbReference type="Gramene" id="KVH93318">
        <property type="protein sequence ID" value="KVH93318"/>
        <property type="gene ID" value="Ccrd_004629"/>
    </dbReference>
    <dbReference type="OMA" id="HMAEFMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009212">
        <property type="entry name" value="Methylthioribose_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01767">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273:SF2">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="9">
        <location>
            <begin position="75"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="9">
        <location>
            <begin position="481"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="867"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="904" mass="102813" checksum="E012AF7D8C0CA271" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XME7</accession>
    <name>A0A103XME7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004792">
        <property type="protein sequence ID" value="KVH93164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XME7"/>
    <dbReference type="STRING" id="59895.A0A103XME7"/>
    <dbReference type="Gramene" id="KVH93164">
        <property type="protein sequence ID" value="KVH93164"/>
        <property type="gene ID" value="Ccrd_004763"/>
    </dbReference>
    <dbReference type="OMA" id="PVMKARN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31110">
        <property type="entry name" value="PESTICIDAL CRYSTAL CRY8BA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31110:SF3">
        <property type="entry name" value="PORTAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="824" mass="93374" checksum="42FF4AA831CF69C2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNP2</accession>
    <name>A0A103XNP2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004570">
        <property type="protein sequence ID" value="KVH94097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNP2"/>
    <dbReference type="STRING" id="59895.A0A103XNP2"/>
    <dbReference type="Gramene" id="KVH94097">
        <property type="protein sequence ID" value="KVH94097"/>
        <property type="gene ID" value="Ccrd_003833"/>
    </dbReference>
    <dbReference type="OMA" id="TIHWFTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF446">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="19850" checksum="8C83CB028996FBE1" modified="2016-04-13" version="1" fragment="single">VQELAARRLCRNHRVVTVNGQFPGPTLEVQNGDSLVVKVTNAAPYNVTIHWFTITDQEGTLWWHAHSRWLRSTVYGALVIRPKSGSSYPFPNPKIEFPVVLGEWWDRKVISVLRQALFTGAAPNVSDALTINGQPGVWLMHCHIDTHLAWGFAMSFIVENGVGESETLLPPPSDLPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNU0</accession>
    <name>A0A103XNU0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004577">
        <property type="protein sequence ID" value="KVH94048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XNU0"/>
    <dbReference type="Gramene" id="KVH94048">
        <property type="protein sequence ID" value="KVH94048"/>
        <property type="gene ID" value="Ccrd_003905"/>
    </dbReference>
    <dbReference type="OMA" id="IQSHPRN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000047">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF21">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="636"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="763" mass="84506" checksum="C7B8EE6F382A9E6F" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPT6</accession>
    <name>A0A103XPT6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase family 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004533">
        <property type="protein sequence ID" value="KVH94699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPT6"/>
    <dbReference type="STRING" id="59895.A0A103XPT6"/>
    <dbReference type="Gramene" id="KVH94699">
        <property type="protein sequence ID" value="KVH94699"/>
        <property type="gene ID" value="Ccrd_003235"/>
    </dbReference>
    <dbReference type="OMA" id="CVEATEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF33">
        <property type="entry name" value="BETA-D-GLUCAN EXOHYDROLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="359" mass="39436" checksum="0C85F7916B8D4B60" modified="2016-04-13" version="1">MGNPIYKNQDEPIESRIKDLLSRMTVKEKVGQMTQIERSVATPSVIKDLCIGSILSCGGSGPFEKATSSDWAEMVDSFQKSALDSRLGIPILYGIDAVHGNNNVYGATVFPHNIGLGATRKQATAADMGQLNSVLGLKLDPLGLEVSGLQGQPPEGYPKNYPFVAGRTNVVACAKHFVGDGGTEQGVNEGNTKVSYEDLERIHMAPYLDCLSQGVCTVMASYSSWNGTNLHESHFLLTEILKEKLGFKVMVPFRYKLYLEDLTHLVESGEIPMSRIDDAVERILRVKFVVGLFEYPLSDKSLLDSVGSKPRKESGNCFKGTVHSFLGRLFRRLKLHGKSPEFPMSANSIYDEISCGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQT0</accession>
    <name>A0A103XQT0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_002774</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQT0"/>
    <dbReference type="STRING" id="59895.A0A103XQT0"/>
    <dbReference type="Gramene" id="KVH95162">
        <property type="protein sequence ID" value="KVH95162"/>
        <property type="gene ID" value="Ccrd_002774"/>
    </dbReference>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="150"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="334"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH95162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="509" mass="56526" checksum="D3D0E5B9FF0D0CC1" modified="2016-04-13" version="1">MPTISDSITKAEKKSKNREHKRKMEEPEPEAEVVVESKKDKKKKKKEKGEKVENANGSVNGSEAINGSEELSEKKKKKKKQKTEEEEVKNNGVEVDEVRKTEDNVVVSGKDISDSKYKALNSFSESKLPEELLECCKNFSKPSPIQSNSWPFLLHGRDFIGIAKTGSGKTLAFGLPAMMHILNKRKNKTTKKVTPLCLVLSPTRELAQQIFDVLAEAGKPSGVRSVCVYGGTSKGPQISALKSGVDIVVGTPGRLKDLIEMGVCQLQEVSFVVLDEADRMLDMGFEPEVRSILSQTSTVRQVVMFSATWPLPVHQLAQEFMDPNPVKVVVGSEDLAANHDVMQIVEVLEDRARDERLVTLLEKYHKSRRGWKVVSISGDKQQKARTEALALFKDGSSPLLVSELFFDVEVVINYSFPLTTEDYVHRIGRTGRAGKKGVAHTFFMKENKGLAGELINVLREAGQNVPANLLNFGTHVKKKESKLYGAHFKEISADAPKATKIKFDSDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRP7</accession>
    <name>A0A103XRP7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZFYVE26-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XRP7"/>
    <dbReference type="Gramene" id="KVH95642">
        <property type="protein sequence ID" value="KVH95642"/>
        <property type="gene ID" value="Ccrd_002316"/>
    </dbReference>
    <dbReference type="OMA" id="KYLHNWD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057946">
        <property type="entry name" value="TPR_ZFYVE26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25569">
        <property type="entry name" value="TPR_ZFYVE26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZFYVE26-like TPR repeats" evidence="3">
        <location>
            <begin position="2455"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1933"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2150"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1737"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1778"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2158"/>
            <end position="2170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2647" mass="296419" checksum="FC6DEC9BA1776128" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSV4</accession>
    <name>A0A103XSV4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_001664</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01004343">
        <property type="protein sequence ID" value="KVH96258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XSV4"/>
    <dbReference type="Gramene" id="KVH96258">
        <property type="protein sequence ID" value="KVH96258"/>
        <property type="gene ID" value="Ccrd_001664"/>
    </dbReference>
    <dbReference type="OMA" id="WDSLYEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17992">
        <property type="entry name" value="DEXHc_RecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047112">
        <property type="entry name" value="RecG/Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47964">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47964:SF1">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_dom3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="630"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="855"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH96258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1126" mass="126267" checksum="E93992A26812C36D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTV2</accession>
    <name>A0A103XTV2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004188">
        <property type="protein sequence ID" value="KVH96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTV2"/>
    <dbReference type="Gramene" id="KVH96797">
        <property type="protein sequence ID" value="KVH96797"/>
        <property type="gene ID" value="Ccrd_001112"/>
    </dbReference>
    <dbReference type="OMA" id="PWCGTKG"/>
    <dbReference type="OrthoDB" id="773436at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000004">
        <property type="entry name" value="WRKY transcription factor 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 30-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096:SF137">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 65 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="295" mass="32799" checksum="74939A3732423A44" modified="2016-04-13" version="1">MAHGFTSLMVDQEDHENSPENSEDSPSSGMFNDTKTTSTSSPKRSRRSIQKRVVSVPIREIEGSRLKGETNAPPSDSWAWRKYGQKPIKGSPYPRGYYRCSSSKGCPARKQVERSRADPTMVMVTYSCDHNHPWPASRNNNHHHNSTVSPPPASTATITEEAPVSNTDDIDQEEDQDPPHDLSKPSTAEPDEKFTSLEVGPGASFITTTDGFGWFSDLESTSSTMLESPLMMAGDMVGDADMAMIFSIREEDESLFADLGELPECTTVFRRREVINEEEHHRRPCKLAPWCGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUZ8</accession>
    <name>A0A103XUZ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_000562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003838">
        <property type="protein sequence ID" value="KVH97335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUZ8"/>
    <dbReference type="STRING" id="59895.A0A103XUZ8"/>
    <dbReference type="Gramene" id="KVH97335">
        <property type="protein sequence ID" value="KVH97335"/>
        <property type="gene ID" value="Ccrd_000562"/>
    </dbReference>
    <dbReference type="OMA" id="AYKPPWM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF141">
        <property type="entry name" value="OS01G0950900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="11">
        <location>
            <begin position="316"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="610" mass="69099" checksum="A02B8A5446F9C772" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV04</accession>
    <name>A0A103XV04_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003832">
        <property type="protein sequence ID" value="KVH97415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV04"/>
    <dbReference type="STRING" id="59895.A0A103XV04"/>
    <dbReference type="Gramene" id="KVH97415">
        <property type="protein sequence ID" value="KVH97415"/>
        <property type="gene ID" value="Ccrd_000468"/>
    </dbReference>
    <dbReference type="OMA" id="IARNWNN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070483">
        <property type="term" value="P:detection of hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="213" mass="23386" checksum="3510D5B2F15BD8C9" modified="2016-04-13" version="1">MPQIQKLYNACKASLSPTGPVSEDALGKIQALLDKIKPSDVGLEQEAQLVRSWTGPMGIFCMPSSSIIPLHNHPGMTVFSKLLYGSMHVNAYDWVDEPPSPSDASQARPAKLVKDGIMTAPCGTTILHPTKGGNIHCFDAITPCAIFDILSPPYSSEDGRHCTYFRRLTDIDPPGTIEVDGEICSEVAWLEEFQPPDDFVIRRGRYKGRVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV34</accession>
    <name>A0A103XV34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">succinate dehydrogenase</fullName>
            <ecNumber evidence="8">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_000411</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV34"/>
    <dbReference type="STRING" id="59895.A0A103XV34"/>
    <dbReference type="Gramene" id="KVH97463">
        <property type="protein sequence ID" value="KVH97463"/>
        <property type="gene ID" value="Ccrd_000411"/>
    </dbReference>
    <dbReference type="OMA" id="MVMVRHA"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF40">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="19" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH97463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="30742" checksum="A15CCF9691ECB822" modified="2016-04-13" version="1" fragment="single">MGFTSSSKRWLTEGYKKVVAGAGGVLNPKQKRFGVLEGHPVGQDHAQQAVQSHETLKDNIKALKKEFKIYRWNPDHPSQKPFLKSYFLDLTTCGPMVLDALQKIKSEDDSTLSYRRSCREGICGSCAMNIDGTNTVACLKPIDTDTSKATYVTPLPHMYVIKDLIEPWLKTKKGPPDGREYRQTPAERKKLDGLYECILCACCSTSCPSYWWNPEDRDDYTEERLEALTENDKRLYRCRIIKNCTATCPKSLNPALAIRQMEAMKSRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVD9</accession>
    <name>A0A103XVD9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003826">
        <property type="protein sequence ID" value="KVH97531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVD9"/>
    <dbReference type="STRING" id="59895.A0A103XVD9"/>
    <dbReference type="Gramene" id="KVH97531">
        <property type="protein sequence ID" value="KVH97531"/>
        <property type="gene ID" value="Ccrd_000354"/>
    </dbReference>
    <dbReference type="OMA" id="CIIPRLE"/>
    <dbReference type="OrthoDB" id="731210at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010449">
        <property type="term" value="P:root meristem growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000158">
        <property type="entry name" value="pentatricopeptide repeat-containing protein At2g33680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF476">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="682" mass="77276" checksum="BCE8711EB7107812" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVZ1</accession>
    <name>A0A103XVZ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">FYVE finger-containing phosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">PIKfyve</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylinositol 3-phosphate 5-kinase type III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ccrd_023886</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XVZ1"/>
    <dbReference type="Gramene" id="KVH97898">
        <property type="protein sequence ID" value="KVH97898"/>
        <property type="gene ID" value="Ccrd_023886"/>
    </dbReference>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000384">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase FAB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000006">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase FAB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="22">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="23">
        <location>
            <begin position="1466"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1225"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1319"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1107"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1231"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1321"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KVH97898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1812" mass="201338" checksum="71CD5F18A35A4C7E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW15</accession>
    <name>A0A103XW15_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="15">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_023868</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 14">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW15"/>
    <dbReference type="STRING" id="59895.A0A103XW15"/>
    <dbReference type="Gramene" id="KVH97937">
        <property type="protein sequence ID" value="KVH97937"/>
        <property type="gene ID" value="Ccrd_023868"/>
    </dbReference>
    <dbReference type="OMA" id="HNAISYW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="13">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH97937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="16802" checksum="DA3B01E1B0F9C975" modified="2016-04-13" version="1" fragment="single">LSRSWANVYLENERTLAIVKPDGVSGNYTSSIRKVILESGFSIQREFTLHLDEDSVRRFYAEHSAKSFFPSLIKYMTSGPVMIMILQKANAVADWRALIGPTDAHKAKMTHADSIRAMCGKDLERNCVHGSDSVESAAREISFFLTEAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWX0</accession>
    <name>A0A103XWX0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maf-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003799">
        <property type="protein sequence ID" value="KVH98403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWX0"/>
    <dbReference type="STRING" id="59895.A0A103XWX0"/>
    <dbReference type="Gramene" id="KVH98403">
        <property type="protein sequence ID" value="KVH98403"/>
        <property type="gene ID" value="Ccrd_023374"/>
    </dbReference>
    <dbReference type="OMA" id="EEVCGFC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF14">
        <property type="entry name" value="MAF-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="283" mass="30515" checksum="652D56375EFB7618" modified="2016-04-13" version="1">MRNQAGSGSGKGPSACAPLIGNWNSPKLLCNSTLFVLSLPKSLLLSNPVMESAESPFRIILGSSSIARRKILAEMGYEFTLMSADIDEKSIRTEKPEELVMALAKAKADAIVSKLQTSADQEKDAKPSILIASDTAEGNPKLQIGEDKDAQPTLLITCDQVVVYEGTIREKPANDEEARQFIKEVTGYSGKHAATVSSVFVTNLTTGFTKGDCDKVEIHFHDIPDHVIDKLLEEGLVLNVAGALIIEHPLIVPYVKELIGTTDSVMGLPKALTQNLLKEAMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX52</accession>
    <name>A0A103XX52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003791">
        <property type="protein sequence ID" value="KVH98543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX52"/>
    <dbReference type="STRING" id="59895.A0A103XX52"/>
    <dbReference type="Gramene" id="KVH98543">
        <property type="protein sequence ID" value="KVH98543"/>
        <property type="gene ID" value="Ccrd_023239"/>
    </dbReference>
    <dbReference type="OMA" id="NQCKKWE"/>
    <dbReference type="OrthoDB" id="1913731at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35689">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35689:SF1">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="37549" checksum="EC02E5E846394D85" modified="2016-04-13" version="1">MDLPQEIDDYLRESIEYSLGLPVSTRTLELKLRSSEEAQRHSRDQCFYLKSKLMEKDKTIDRVRAEASMNAQAVKRFVEENQKLAMECDNLLSQCTKWEKECSLYDRDREALMDFGNEADERAKEAELRVHYLEEELSKLSEELQYFKQQSNVQKVGEPTDNESTEHLLIDALLSTLINKEEIASTAHSFLEANIGVDVCQKMLKRWDRLKPSARAVLSLASEVKKLQEDKDHLRINLTKAEEEVTVLFDENNVLDKENRRLMKLLQKERHLLDSGGKRSSASIKNHKRKSSPCPKESSPIEKKIDFSDATSSPRQPLSPLLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXD8</accession>
    <name>A0A103XXD8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003774">
        <property type="protein sequence ID" value="KVH98646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXD8"/>
    <dbReference type="STRING" id="59895.A0A103XXD8"/>
    <dbReference type="Gramene" id="KVH98646">
        <property type="protein sequence ID" value="KVH98646"/>
        <property type="gene ID" value="Ccrd_023119"/>
    </dbReference>
    <dbReference type="OMA" id="MMKLTWK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052658">
        <property type="entry name" value="TPR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544">
        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="14525" checksum="1645E09FE480D80E" modified="2016-04-13" version="1">MMKLTWKNKNNKRPITTISHLPFDQEELTSTDEERCKAGDDGSAQPSTAVSPVDETIRLAESFEAQGNKLAELGKYREALGKWEAAITLMPERATLHEEKAQVLLEIGETWKSLLAATRATQLEPSWAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY63</accession>
    <name>A0A103XY63_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterile alpha motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003639">
        <property type="protein sequence ID" value="KVH99013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY63"/>
    <dbReference type="STRING" id="59895.A0A103XY63"/>
    <dbReference type="Gramene" id="KVH99013">
        <property type="protein sequence ID" value="KVH99013"/>
        <property type="gene ID" value="Ccrd_022756"/>
    </dbReference>
    <dbReference type="OMA" id="DNEREPN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="27892" checksum="1FEA1259A9E93586" modified="2016-04-13" version="1">MSELQPPVEGQMNGGGGGGGGGALVGVPADAVVGPPKRQRRPSVRLGDIGDQHTFDNQRRTKQQQWKFPSKDSKSSKTRPLVNLTGGGGGAITGTKRVRSNWGSKMDEGDEKFDDEDDYDDDGYRDFDREGSGSQLKEQSLNFSMDNERDLHYVGGSRGRDGVRVRVSDGVELDGPSDTDARNWNNNHPERNGVRVWLNQLGLGRYAPVFEIHEVDDEVLPLLTLEDLKDMGINAVGSRRKMFCSIQKLGKGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYA2</accession>
    <name>A0A103XYA2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYA2"/>
    <dbReference type="STRING" id="59895.A0A103XYA2"/>
    <dbReference type="Gramene" id="KVH99073">
        <property type="protein sequence ID" value="KVH99073"/>
        <property type="gene ID" value="Ccrd_022645"/>
    </dbReference>
    <dbReference type="OMA" id="GQDYIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12622" checksum="7537E9E96A4FBCEF" modified="2016-04-13" version="1">MSELDIQIPSAFDPFAEANAEDSGAGSKEYVHIRVQQRNGRKSLTTVQGLKKDFSYNKILKDLKKEFCCNGTVVQDPELGQVIQLQGDQRKNVSSFLTQAGIVKKDHIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ08</accession>
    <name>A0A103XZ08_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003478">
        <property type="protein sequence ID" value="KVH99503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH99503">
        <property type="protein sequence ID" value="KVH99503"/>
        <property type="gene ID" value="Ccrd_022262"/>
    </dbReference>
    <dbReference type="OMA" id="YHELDTH"/>
    <dbReference type="OrthoDB" id="1729427at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF10">
        <property type="entry name" value="COPIA-LIKE POLYPROTEIN_RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="19814" checksum="DF71EE937FBE81FA" modified="2016-04-13" version="1">MKPGATALDLWKSLQDIFLNNKTTRAVYLEEQFNNTRLASFSNVTEYCARLKNLVDQLDNVGNPVSETKMVLQLIXGLTKGEYDTVATFIQQTEPLPSFNRAKSSLLLEEARRNKPDPTTPQALVTQRADYNQAEHLPSSHNHSSSRGQSRGSQRGRDGHRGNKWSLYFCSSAMAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ43</accession>
    <name>A0A103XZ43_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003457">
        <property type="protein sequence ID" value="KVH99524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ43"/>
    <dbReference type="STRING" id="59895.A0A103XZ43"/>
    <dbReference type="Gramene" id="KVH99524">
        <property type="protein sequence ID" value="KVH99524"/>
        <property type="gene ID" value="Ccrd_022241"/>
    </dbReference>
    <dbReference type="OMA" id="ECHDIEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043891">
        <property type="entry name" value="SPARK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19160">
        <property type="entry name" value="SPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119230" evidence="4">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SPARK" evidence="5">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="37226" checksum="95C7B35367EF1D96" modified="2016-04-13" version="1">MNFFLLLCLLILPSLSLSTNSTSCPIDFNYVNTFPWDTSACTATATATQNCCQTLRGLIGIGLADHLKKTSTFFLPNLQSSNSCLSDFQSHLSSVDVRQPFSDCLTTASEFVANPLNCAEIVTLSDWVKYAGPTTTLDSTCDEDLTGFLRCSSCLDAGMAVNARLVSLSQNSTKCFTFTALYVAGIVSSLGPEDIQTADCVLGIPLLKSRSNKRSKKTTIFAISGASVGVIMFLVVIFVYRKRNNNREQTAFHRDYVQNIRHRNLLPLRGFCATSNPMNGNEQFLVYNYMPNGSLHDHIFNKTTSNRRLSWPQRKSIILDGYLICTTGSNPLYFIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZF0</accession>
    <name>A0A103XZF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003426">
        <property type="protein sequence ID" value="KVH99645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZF0"/>
    <dbReference type="STRING" id="59895.A0A103XZF0"/>
    <dbReference type="Gramene" id="KVH99645">
        <property type="protein sequence ID" value="KVH99645"/>
        <property type="gene ID" value="Ccrd_022118"/>
    </dbReference>
    <dbReference type="OMA" id="TQYHELM"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000065">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1557">
        <property type="entry name" value="7-DEOXYLOGANETIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="261" mass="29089" checksum="B3F233B7E5A27CC2" modified="2016-04-13" version="1" fragment="single">MDSKQKMQHVLCMPAPAQGHINPMLKLAKILHSKGFSITFVNTEFNHQRLLRSQGSDALRGFPSFCFETIPDGLPTPENLNATQDVPSLCKAMDEKFVVPFKSLLNKLSASDSPVTYIVADVIMSFTLEAAMEMDIPEILFWTGGAGSLLCIEQYPNLLDKGLMPLKDSSYLVNGYLDTSYDCIPSMSGIRLKDIPPFIRITNPGDEYMVEFFTRQIERAKTASTIVLNTYHELEPNILDALSSIFPPCYGIGPLNLLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y086</accession>
    <name>A0A103Y086_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-carbamoylputrescine amidase</fullName>
            <ecNumber evidence="8">3.5.1.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in polyamine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-carbamoylputrescine + H2O + 2 H(+) = putrescine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:22284"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58318"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.1.53"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (amidase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbon-nitrogen hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.53" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01003400">
        <property type="protein sequence ID" value="KVI00066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y086"/>
    <dbReference type="STRING" id="59895.A0A103Y086"/>
    <dbReference type="Gramene" id="KVI00066">
        <property type="protein sequence ID" value="KVI00066"/>
        <property type="gene ID" value="Ccrd_021687"/>
    </dbReference>
    <dbReference type="OMA" id="APYFCQV"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033388">
        <property type="term" value="P:putrescine biosynthetic process from arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07573">
        <property type="entry name" value="CPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000012">
        <property type="entry name" value="N-carbamoylputrescine amidohydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017755">
        <property type="entry name" value="N-carbamoylputrescine_amidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03381">
        <property type="entry name" value="agmatine_aguB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="33332" checksum="989F0C2662B542CC" modified="2016-04-13" version="1">MEGRKVVLSALQFACADDVATNVDTAERLVRSAHEKGANIILIQELFEGYYFCQAQREDFFQRAKPYKEHPTVLRMQALAKELGVVIPVSFFEEANNAHYNSIAIIDADGTDLGLYRKSHIPDGPGYEEKFYFNPGDTGFKVFQTKFAKIGVAICWDQWFPEAARAMVLQGAEILFYPTAIGSEPQDEGLDSRDHWKRVMQGHAGANLVPLVASNRIGKEVIQTEHGNSSITFYGNSFISGPSGEIIAVANDKEEAVLIAEFDLDKIKSKRHSWGIFRDRRPDLYKVLLTLDGHNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0A4</accession>
    <name>A0A103Y0A4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y0A4"/>
    <dbReference type="Gramene" id="KVI00159">
        <property type="protein sequence ID" value="KVI00159"/>
        <property type="gene ID" value="Ccrd_021628"/>
    </dbReference>
    <dbReference type="OMA" id="WGADIDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138">
        <property type="entry name" value="OS01G0690200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138:SF72">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE CARBOXY-TERMINAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119262" description="non-specific serine/threonine protein kinase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase C-terminal" evidence="9">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="30538" checksum="ED8E5A43B95678B9" modified="2016-04-13" version="1">MTTRLHPTPTLFVSAVILAIVVRFPAIRCQGTSRYDACGESIECGNDRLEYPFWGSGRPAYCGHSGFQLTCQSSVFILNYESVDYRVLRMXTSTQVITIARNDLYTDSCPRYLYNTTYNSTLFNDDNFDQENVSLYYGCNSTLTTVTLPFAGYIFECNVNDTQTDSYFYRTSLVNSNLINSFQLVSCNNHITVPVNQTSATQLGLPTATTSQLRSALTSGFNLRWTVYKDECDRCMRSEGRCGSNSTSGESFACYCASGEFSRTCNNSNEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2S5</accession>
    <name>A0A103Y2S5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003089">
        <property type="protein sequence ID" value="KVI01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2S5"/>
    <dbReference type="Gramene" id="KVI01459">
        <property type="protein sequence ID" value="KVI01459"/>
        <property type="gene ID" value="Ccrd_020271"/>
    </dbReference>
    <dbReference type="OMA" id="CMDIGDI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37256">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37256:SF1">
        <property type="entry name" value="MYB-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40586" checksum="D468E9452DA3D5D9" modified="2016-04-13" version="1">METDKVDEAKQDPRLSGAYIRTLVKHLTAKDPLDGDGGITKNLNENEEHQKRPTQPPQHKKQVRRRLHTNRPYQERLLNMAEARREIVTALKFHRASMKQQQQEEAANNLDLQSEQSPSLGQEKKTKSRRILGLYPSTTATATNSYSSLSSPPPVPCYWPISTIVPPPPPSYHDNLNFVLPSQTLGLNLNFQNFSNLDTHLYHKPMSMYSSSPVSSTPSTSSSAPVSAAAEELVVGKPKETVSNSSGGGGLHHHAMDDEEMEEIRSLGEQHQMEWNDTINLVTSARWSNFLKTMEIEAEEGDEYDGFDQVMEFPDWLMNANESSCLEQQFDDHFSDAYLQDPALPCMDIGEIEGMDGEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y414</accession>
    <name>A0A103Y414_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ran GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Intracellular vesicle trafficking and protein transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002663">
        <property type="protein sequence ID" value="KVI02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y414"/>
    <dbReference type="STRING" id="59895.A0A103Y414"/>
    <dbReference type="Gramene" id="KVI02125">
        <property type="protein sequence ID" value="KVI02125"/>
        <property type="gene ID" value="Ccrd_019609"/>
    </dbReference>
    <dbReference type="OMA" id="QISYNEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000263">
        <property type="entry name" value="Ras-related protein RABB1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="21424" checksum="79A012DCF8F8D018" modified="2016-04-13" version="1" fragment="single">MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDNKPIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRETFNHLASWLEDARQHANANMTVMLIGNKCDLAHRRAVSTEEGEQFAKENGLIFMEASAKTAQNVEEAFINTAGTIYKKIQDGVFDVSNEARVTLLFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4D6</accession>
    <name>A0A103Y4D6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002658">
        <property type="protein sequence ID" value="KVI02318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4D6"/>
    <dbReference type="STRING" id="59895.A0A103Y4D6"/>
    <dbReference type="Gramene" id="KVI02318">
        <property type="protein sequence ID" value="KVI02318"/>
        <property type="gene ID" value="Ccrd_019396"/>
    </dbReference>
    <dbReference type="OMA" id="NKCANIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF195">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="23332" checksum="3944D022E21AD203" modified="2016-04-13" version="1" fragment="single">KLTLEGGIPESPKDLDRLECLEKLNLLSTKITHLPDSICKLKHLKDLKLDPYWFLEKLPQDLGRLECLEKLILSECVILRHIPDSICNMKLLQYFLLPGCIAIEKLPEEIGRLKCLRELNIEGTNIRHLPESIFELRCLRIVGYRLLLQSYGLTSPIQTAEDETFFYVELILDNVAVTRTRSCSICQHRYLVGPNVLMVHHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5M7</accession>
    <name>A0A103Y5M7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The PPC domain mediates interactions between AHL proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002607">
        <property type="protein sequence ID" value="KVI02965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5M7"/>
    <dbReference type="STRING" id="59895.A0A103Y5M7"/>
    <dbReference type="Gramene" id="KVI02965">
        <property type="protein sequence ID" value="KVI02965"/>
        <property type="gene ID" value="Ccrd_018743"/>
    </dbReference>
    <dbReference type="OMA" id="ATYISMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039605">
        <property type="entry name" value="AHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500:SF85">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="7">
        <location>
            <begin position="139"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="247" mass="25240" checksum="9ED1CC15DA6138B9" modified="2016-04-13" version="1">MSYEASTMSNNMQLAYTADGTATYISMSRPASSSSPSPTPTYNNPNGAGAGGRNTGENNSIAMVTAGMDAYGGEVVKRKRGRPRKYAPDVSLSPAARLSPPGQAAPQVSGLSSPALSSGKKPRGRPPGSLNKQQPAASGSPGVGFMPHILDVKAGEDVLAKLMWFAQNSTRALCVLSANGAVSNVTLQQSATSGGTVTYEGRFEILSLSGSFMVSETGGQRSRTGGLSVALSGSDGRVLGVLRSHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7K9</accession>
    <name>A0A103Y7K9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002319">
        <property type="protein sequence ID" value="KVI03982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7K9"/>
    <dbReference type="Gramene" id="KVI03982">
        <property type="protein sequence ID" value="KVI03982"/>
        <property type="gene ID" value="Ccrd_017709"/>
    </dbReference>
    <dbReference type="OMA" id="ISMVCKS"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010011">
        <property type="term" value="F:auxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010152">
        <property type="term" value="P:pollen maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000006">
        <property type="entry name" value="Transport inhibitor response 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000029">
        <property type="entry name" value="Transport inhibitor response 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041567">
        <property type="entry name" value="COI1_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041101">
        <property type="entry name" value="Transp_inhibit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF149">
        <property type="entry name" value="F-BOX DOMAIN, LEUCINE-RICH REPEAT DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18511">
        <property type="entry name" value="F-box_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18791">
        <property type="entry name" value="Transp_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="585" mass="65885" checksum="09C8FFE166F51232" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7N7</accession>
    <name>A0A103Y7N7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper chaperone SCO1/SenC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002315">
        <property type="protein sequence ID" value="KVI04027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7N7"/>
    <dbReference type="STRING" id="59895.A0A103Y7N7"/>
    <dbReference type="Gramene" id="KVI04027">
        <property type="protein sequence ID" value="KVI04027"/>
        <property type="gene ID" value="Ccrd_017670"/>
    </dbReference>
    <dbReference type="OMA" id="HSSSYMR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF1">
        <property type="entry name" value="PROTEIN SCO1 HOMOLOG 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="312" mass="35226" checksum="3205E7FBC60DD3A3" modified="2016-04-13" version="1">MVETHEVETYLEREATELWGREVDDPFFWICICPIPGAKPLLFPITYYVLPPPEENPLPEFCVLGIPFAVQLLQFMPVSKVSLFSIGKKSAESLFFPRRYVTRMGFHSSSYMRAAKMSNEGRRLLLGQGQLESPLRRVYLIPTVILGGIGGAFIFWHMNDEKRAIHKGQGSNDGCCTMKGPVIGGPFNLIDSHGRLVTEEDLRGGWILLYFGYTSSPDVGPAELLKLAKAINTLESKYGIKVRPVFVTIDPQRDTPSQLRAYLKEFDERIMGLTGPVGAVRQMAHEYRVYFKKVEEDGDDYLIHNESRKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8J7</accession>
    <name>A0A103Y8J7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002031">
        <property type="protein sequence ID" value="KVI04493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8J7"/>
    <dbReference type="STRING" id="59895.A0A103Y8J7"/>
    <dbReference type="Gramene" id="KVI04493">
        <property type="protein sequence ID" value="KVI04493"/>
        <property type="gene ID" value="Ccrd_017189"/>
    </dbReference>
    <dbReference type="OMA" id="MYKKDPN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010235">
        <property type="term" value="P:guard mother cell cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009825">
        <property type="term" value="P:multidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000624">
        <property type="entry name" value="DENN domain and WD repeat-containing protein SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000007">
        <property type="entry name" value="DENN domain and WD repeat-containing protein SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1273" mass="141589" checksum="7294DBD413B652F7" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAE7</accession>
    <name>A0A103YAE7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_016150</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAE7"/>
    <dbReference type="STRING" id="59895.A0A103YAE7"/>
    <dbReference type="Gramene" id="KVI05483">
        <property type="protein sequence ID" value="KVI05483"/>
        <property type="gene ID" value="Ccrd_016150"/>
    </dbReference>
    <dbReference type="OMA" id="CWSGDIH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000355">
        <property type="entry name" value="Integrin-linked protein kinase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="156"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI05483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="48904" checksum="CC87CA13056D332B" modified="2016-04-13" version="1">MSGSEGSSGHSAGDAQVAAAGKKRDKAKVSRTSLILWHAHQNDPVAVRKLLEEDRSLVQARDYDNRTPLHVASLHGWIEVAKILIEYGADVNAQDRWKNTPLADADGARKHHMIELLKSYGGLSFGQNGSHFEPRPVPPPLPNKCDWEIDPLELDFTTSHMIGKGSFGEIVRACWRGTPVAVKRILPSLSDDKLVIQDFRHEVNLLVKLRHPNIVQFLGAVTEKKPLMLITEYLRGGDLHQCLKEKGALSAATAVSFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSNADHLKVGDFGLSKLIRVQNSHDIYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILFEMLEGEPPLSHYEAYEAAKYVSEGNRPIFRAKSYTPELKELTEHCWAADMNKRPSFLEILKRLEKIKETIHPDHHHWHIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAF3</accession>
    <name>A0A103YAF3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Son of sevenless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAF3"/>
    <dbReference type="STRING" id="59895.A0A103YAF3"/>
    <dbReference type="Gramene" id="KVI05481">
        <property type="protein sequence ID" value="KVI05481"/>
        <property type="gene ID" value="Ccrd_016156"/>
    </dbReference>
    <dbReference type="OMA" id="YFSCRSF"/>
    <dbReference type="OrthoDB" id="1926790at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133">
        <property type="entry name" value="OS08G0107100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40377" checksum="FFCAB16D226F0C05" modified="2016-04-13" version="1">MESPKGPSPRLNTISLHKEKNETPDLQTFGQELPDHVTRSDHVFQSTSALEILRETVRILRYNLSGFMAIGALLICPVSAVLLSNVLVDQSIVKRLAIRLLLVAKSSGLPLRPFVEHSSQKFSEMAISTTMCFPLYITLLLISKAAVVYSVDCTYSRKKFDSSKFYVIIRKIWRRIVSTYLLACTVIVGCLTLFLVLLAAVSSLLSVIGFFPDFIAYTAILIGLFFSVFFANAIIICDLSMVISVLEDVSGSEALLRSTVLIRGQTQVGLMIFLGSTIGMALVEGLFEHRVKTLSYGDGSSRIWEGPLLVLMYSFVVLIDFMMSTVFYFSCKSYSLENGSSIECQSVLEALTASPIASDDPSPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAV9</accession>
    <name>A0A103YAV9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAV9"/>
    <dbReference type="STRING" id="59895.A0A103YAV9"/>
    <dbReference type="Gramene" id="KVI05697">
        <property type="protein sequence ID" value="KVI05697"/>
        <property type="gene ID" value="Ccrd_015888"/>
    </dbReference>
    <dbReference type="OMA" id="MFPDIMG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31903">
        <property type="entry name" value="F12F1.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31903:SF4">
        <property type="entry name" value="OS11G0490300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="208" mass="23490" checksum="D6D2F5927DB02B3F" modified="2016-04-13" version="1">MRNKGKVYPSSSSSCTPFPAEDLDTDSLSVLKLLPATILGLALLLSLQDRQVLAYMITRSINSTHPSVDKKKPSNNHNPPPLFYCDCFDCYTSYWFKWDSSPNRELIHQAIEAFEETLTHGEQSRKKAKKRERIYSPPPERLQVVEEKAEEDGVLNIAAEEKADAQPPEAAVLVAASQHKGLARKVLPDVIGLFHWRLWSLWSPNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBW0</accession>
    <name>A0A103YBW0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSXT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBW0"/>
    <dbReference type="STRING" id="59895.A0A103YBW0"/>
    <dbReference type="Gramene" id="KVI06245">
        <property type="protein sequence ID" value="KVI06245"/>
        <property type="gene ID" value="Ccrd_015421"/>
    </dbReference>
    <dbReference type="OMA" id="ENAHPGA"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="23722" checksum="FD2C721D7953ECFF" modified="2016-04-13" version="1">MQQHLMQMQPMMAAYYPTNNVTTDHIQQYLDENKSLILKIVESQNSGKMAECAEHQAKLQRNLMYLAAIADSQPQAPALHSQYPQGGMMQQPGGHYMQQHQHQHQHQQVQQMSPQALMAARSSMLYSQQQYSSLQQQQALHSQLGMNSGGGTSGLHMLQSDNNNAAAVGGTHLGGGFPDFGRKQDIGVSGPTNEGRGGGSSSGGDGGETLYLKSPDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC53</accession>
    <name>A0A103YC53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001832">
        <property type="protein sequence ID" value="KVI06382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC53"/>
    <dbReference type="STRING" id="59895.A0A103YC53"/>
    <dbReference type="Gramene" id="KVI06382">
        <property type="protein sequence ID" value="KVI06382"/>
        <property type="gene ID" value="Ccrd_015293"/>
    </dbReference>
    <dbReference type="OMA" id="WRRDDDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000383">
        <property type="entry name" value="RING/U-box superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="300" mass="33497" checksum="2C448B2E017DF85F" modified="2016-04-13" version="1" fragment="single">AVIYRQKINLLSNPCIHRFLSVLHLQSSRYFLPISIFFQQFSTMVYDSIANASIPTAASNSKDFGKKKRVNRTAKLKQCKLDVRREQWLSQVKNRGFKEETHGTGGMKAPAPETHAANEREPPVVNLEVNLGGEETEADALAADDIQKNHNDPNLVSPVDEQLDFHTIPEPEPVLTTPAGQEDCRPPTSFRAWRPDDASRPQNLPNLLKQNSFPMKSGKHYGLHSGGFAPSSCPICCEDLDMTDSSFLPCPCGYRLCLFCHKRILEDNGRCPGCRKLYAQPDNGNASSKMARSCSMNPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCK2</accession>
    <name>A0A103YCK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001781">
        <property type="protein sequence ID" value="KVI06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCK2"/>
    <dbReference type="Gramene" id="KVI06619">
        <property type="protein sequence ID" value="KVI06619"/>
        <property type="gene ID" value="Ccrd_015028"/>
    </dbReference>
    <dbReference type="OMA" id="ISWCSIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="665" mass="72827" checksum="7060931CE23AD93E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDH9</accession>
    <name>A0A103YDH9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001524">
        <property type="protein sequence ID" value="KVI07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDH9"/>
    <dbReference type="STRING" id="59895.A0A103YDH9"/>
    <dbReference type="Gramene" id="KVI07087">
        <property type="protein sequence ID" value="KVI07087"/>
        <property type="gene ID" value="Ccrd_014572"/>
    </dbReference>
    <dbReference type="OMA" id="CTRIPCC"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF434">
        <property type="entry name" value="THIOREDOXIN H9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="14362" checksum="039DBC12724E48A3" modified="2016-04-13" version="1">MRPGSKQYLASELGGGKVTLITTTEKWDEKLTEAKNKGQLVVVNFSAAWSTPCRFIATAYRNLADKHDSLMFLTVDVDQLPEFSTSWNIKATPTFFFLINGQPIDSFVGADEKELAKKIEAAAAGFIQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEI0</accession>
    <name>A0A103YEI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSL (TC 2.A.67.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEI0"/>
    <dbReference type="STRING" id="59895.A0A103YEI0"/>
    <dbReference type="Gramene" id="KVI07624">
        <property type="protein sequence ID" value="KVI07624"/>
        <property type="gene ID" value="Ccrd_014023"/>
    </dbReference>
    <dbReference type="OMA" id="ACYNIAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051980">
        <property type="term" value="F:iron-nicotianamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF66">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER, OPT SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="10573" checksum="E745C4346BFB8768" modified="2016-04-13" version="1">MEASNERETMEIETPVVQSVIVTKLNLTTGLVPNLNVSAALLAFVFITTWTKLVRKAGFLTTPFTGQENTIIQTCAVACYNIAYGGLILRFDFNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEU0</accession>
    <name>A0A103YEU0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001488">
        <property type="protein sequence ID" value="KVI07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEU0"/>
    <dbReference type="Gramene" id="KVI07782">
        <property type="protein sequence ID" value="KVI07782"/>
        <property type="gene ID" value="Ccrd_013861"/>
    </dbReference>
    <dbReference type="OMA" id="NTHYNEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35111:SF5">
        <property type="entry name" value="F10A5.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35111">
        <property type="entry name" value="F10A5.9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="85" mass="9107" checksum="1218D1D57F4F4983" modified="2016-04-13" version="1">MRFMFSIPSSKATASSGGGSGAVRRRSCDRPDPPRASCNSSSYYSSNTHYNEAIADCIEFFNKSSSSSSSPSFSRDGGRMSDVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEX6</accession>
    <name>A0A103YEX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001483">
        <property type="protein sequence ID" value="KVI07841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEX6"/>
    <dbReference type="Gramene" id="KVI07841">
        <property type="protein sequence ID" value="KVI07841"/>
        <property type="gene ID" value="Ccrd_013803"/>
    </dbReference>
    <dbReference type="OMA" id="HFATYQV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37203:SF3">
        <property type="entry name" value="SLR0975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="38049" checksum="917CEFBFC23A4666" modified="2016-04-13" version="1">MSLTTTFHPFSSIYTHHTRSPISTNLAHCAVSTSSFRHSGARLLGFCPHAISTQDQGVFDSELHSVLQLATGSELYEVERILFGTRCNLFTLVYFSPLLKSIAKPSDIDYVMIEEDPEVREDFIRILESRFFFLAADARSSLRGWRPTYRNVLLGVRKELKVPCSTKLSTEDLEIEIFLHLLQEYSSEGSGNIVAKWGSSKHASDTQSSLEVGLSPWKVQAFAALGRGADEFFTTILKGGGMFTVGRLYNLVSSKLSGKVFLEAANYQIKKEVLKEGLAGAASRYLGVRSIMVLLGPMLWGTFLADLVIQMLGTDYARIVRAIYAFAQIRISRTYKLPSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFM3</accession>
    <name>A0A103YFM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase, FKBP-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001194">
        <property type="protein sequence ID" value="KVI08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFM3"/>
    <dbReference type="STRING" id="59895.A0A103YFM3"/>
    <dbReference type="Gramene" id="KVI08216">
        <property type="protein sequence ID" value="KVI08216"/>
        <property type="gene ID" value="Ccrd_013414"/>
    </dbReference>
    <dbReference type="OMA" id="RWADKIQ"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046967">
        <property type="term" value="P:cytosol to endoplasmic reticulum transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053319">
        <property type="entry name" value="OEP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48433">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 61-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48433:SF1">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 61-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="584" mass="64926" checksum="8268C6186BB85CB2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFV7</accession>
    <name>A0A103YFV7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001139">
        <property type="protein sequence ID" value="KVI08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFV7"/>
    <dbReference type="STRING" id="59895.A0A103YFV7"/>
    <dbReference type="Gramene" id="KVI08324">
        <property type="protein sequence ID" value="KVI08324"/>
        <property type="gene ID" value="Ccrd_013301"/>
    </dbReference>
    <dbReference type="OMA" id="WMYYPPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1320.10">
        <property type="entry name" value="Outer-capsid protein sigma 3, large lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF24">
        <property type="entry name" value="OS07G0205500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119688" description="Neprosin PEP catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="2">
        <location>
            <begin position="172"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="47893" checksum="4F5C50542F49DBDA" modified="2016-04-13" version="1">MAVAYFSRSRKRIVFLFIFFIVCGLISLSCAARQPKASRQKLQVHKHLKRLNKAPVKTIQSPDGDMIDCVHISHQPAFDHPFLKDHKIQMRPNYHPEGIYDENKVNTESNKRENTINQLWHVNGMCPEDTIPIRRTKEDDVLRASSVKRYGKKKHTSIPVPRSIPKSADPDLVNESGHQHAIAYVEGDKFYGAKATMNVWEPKIQQPNEFSLSQIWILGGSFGEDLNSIEAGWQVSPDLYGDNNTRLFTYWTSDAYQATGCYNLLCSGFIQINNNIAMGASISPVSAYRNSQYDISILVWKEGNWWMQFGNGYVLGYWPSFLFSYLADSATMIEWGGEVVNSEPDGQHTSTQMGSGRFPEEGFGKASYFRNIQVVDKENNLKAPKDIGTFTEQSNCYDVQTGSNSDWGHYFYYGGPGKNPNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGN3</accession>
    <name>A0A103YGN3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_012904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001093">
        <property type="protein sequence ID" value="KVI08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGN3"/>
    <dbReference type="STRING" id="59895.A0A103YGN3"/>
    <dbReference type="Gramene" id="KVI08722">
        <property type="protein sequence ID" value="KVI08722"/>
        <property type="gene ID" value="Ccrd_012904"/>
    </dbReference>
    <dbReference type="OMA" id="EYFKGVY"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000070">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF14">
        <property type="entry name" value="PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="311" mass="34193" checksum="48AC066A1FF077E8" modified="2016-04-13" version="1">MLQETKLCEEFSAKYYGICALGGMVSAGATHVAITPLDVLKVNMQVNPVKYNSISTSFTTLLREDGVSAFRRGWTGKFFGYGVQGACRFGLYEYFKKLYSNILKDQNKTTIFFFSSASAEVIANVALCPFEAIKVRVQAQPQFAKGLADGFPKLYASEGLHGLYKGLIPLWGRNLPFSMIMFSTFEHSVDFLYRKAIQRKKEDCSITQQLGVTCLAGYAAGSVGSIISNPADNIVASLNNKKAGSLKLVVKKIGLRNLFTRSLPIRIMLVGPVVTLQWLFYDTIKVLSGLPTSGHICSEVEDTGDKIQVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH35</accession>
    <name>A0A103YH35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromo domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001077">
        <property type="protein sequence ID" value="KVI08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH35"/>
    <dbReference type="STRING" id="59895.A0A103YH35"/>
    <dbReference type="Gramene" id="KVI08963">
        <property type="protein sequence ID" value="KVI08963"/>
        <property type="gene ID" value="Ccrd_012659"/>
    </dbReference>
    <dbReference type="OMA" id="CICHANT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="135"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="360" mass="41447" checksum="2F99B3FDDE5B29F9" modified="2016-04-13" version="1">MGSSKEDYATDADNSAGDHRRLDSNCKVFSDGEKVLAYHGPRIYEAKACSKIRDAEERVEIFRSLPCKLETCLQLIVPLHEYWDEWVGVERLMKYTQENIQKQQDLGKKQGVDRNPKSGRSNQTKPKISTGAKGKKRKNDSSTEKEIASIEKLVNIEIPSTLKKQLVDDWEFVNEQDKLVKLPRSPNVDDILDSYLEYRSKKDGILYHLLLGLRKFHGCICHANTTDKSTSRGATLMPEYRMTDSIGEILKGLRCYFDRALPVILLYDKERQQYRESVADDASPSSIYGAEHLLRLFVKLPELLPYLNIEEDLVMRLQQKFLDFLRFLQKKQTSFFISSYDDDSKVSEASSVVRPKTSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHV4</accession>
    <name>A0A103YHV4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHV4"/>
    <dbReference type="STRING" id="59895.A0A103YHV4"/>
    <dbReference type="Gramene" id="KVI09353">
        <property type="protein sequence ID" value="KVI09353"/>
        <property type="gene ID" value="Ccrd_012253"/>
    </dbReference>
    <dbReference type="OMA" id="CELGLIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="220" mass="24442" checksum="2FB7FE603D1637E6" modified="2016-04-13" version="1">MMQRLATAVFYFLVCVAYTTYYPIVKVKFCFEEEYGGLGLGYSYHCIPLEEISRASASVGLSLFSTAQKLDKLGMRGSDTCELVFDNCFVPEENVLGEEGKGVYVMMSGLDLERLVLAAGPIGIMQSCLDVVLPYVRQREQFGRPIGEFQLMEDCAGVILVAAERATQVALQAIQCLGGNGYMNEYPTGRFLRDAKLFEIGAGTSEIRRMIIGRELFKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHX5</accession>
    <name>A0A103YHX5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">adenylyl-sulfate reductase (glutathione)</fullName>
            <ecNumber evidence="18">1.8.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_012250</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Reduces sulfate for Cys biosynthesis. Substrate preference is adenosine-5'-phosphosulfate (APS) &gt;&gt; 3'-phosphoadenosine-5'-phosphosulfate (PAPS). Uses glutathione or DTT as source of protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>glutathione disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + 2 glutathione</text>
            <dbReference type="Rhea" id="RHEA:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the APS reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.9" evidence="18"/>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHX5"/>
    <dbReference type="STRING" id="59895.A0A103YHX5"/>
    <dbReference type="Gramene" id="KVI09409">
        <property type="protein sequence ID" value="KVI09409"/>
        <property type="gene ID" value="Ccrd_012250"/>
    </dbReference>
    <dbReference type="OMA" id="TRTGMEN"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033741">
        <property type="term" value="F:adenylyl-sulfate reductase (glutathione) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009973">
        <property type="term" value="F:adenylyl-sulfate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02993">
        <property type="entry name" value="PDI_a_APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000153">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000252">
        <property type="entry name" value="Phosphoadenosine-phosphosulphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004508">
        <property type="entry name" value="Thioredoxin-indep_APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00424">
        <property type="entry name" value="APS_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482:SF9">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="13" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioredoxin" evidence="20">
        <location>
            <begin position="348"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="464" mass="51335" checksum="009E5A2A9A151CA1" modified="2016-04-13" version="1">MALAVTASSSSTSIAFSSNSRKEQGVQFSSSNFQPSDRFNSSPAALSLSLKRSIAVKPLNAEPKRNDSIVPSAATIFAPDVEKAVGIEDIEKLAKNLEKASPLEIMDKALEKYGNDIAIAFSGAEDVALIEYAHLTGRPFRVFSLDTGRLNPETYKFFDTVEKHYGIHIEYMFPDAVEVQALVRTKGLFSFYEDGHQECCRVRKVRPLRRALKGLRAWITGQRKDQSPGTRSEVPVVQVDPVFEGMDGGSGSLVKWNPVANVAGNDIWNFLRTMDVPVNSLHAQGYVSIGCEPCTRSVLPGQHEREGRWWWEDAKAKECGLHKGNLKEESVNGNGAANGNSSSANSDIFESQNIVNLTRPGIENLVKMEDRKEPWMVVLYAPWCPFCQAMEASYNELADKLAGSGVKVGKFQADGDQKAYAKQELQLGSFPTILFFPKHASRPIKYQSEKRDVESLMGFINALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI18</accession>
    <name>A0A103YI18_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_012197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001062">
        <property type="protein sequence ID" value="KVI09443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI18"/>
    <dbReference type="STRING" id="59895.A0A103YI18"/>
    <dbReference type="Gramene" id="KVI09443">
        <property type="protein sequence ID" value="KVI09443"/>
        <property type="gene ID" value="Ccrd_012197"/>
    </dbReference>
    <dbReference type="OMA" id="YHAMKVV"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000294">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000312">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI09443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="388" mass="44108" checksum="08E02EAEF5BEBED4" modified="2016-04-13" version="1">MEATPLQDLHLHNLRAIKVLGNGAMGTVFLVHNLISNPSARSPFALKVVEKSCLQSDRRALWEISVLNRLNHKPHPFLPFLIGFLETHEFLAWAIPFCPGRDLNVLRNRQTDHVFSASAIRFYLAEIICALQHLHTMGIVYRDLKPENVLIQQSGHVTLTDFDLSRTLTAKSLQSLLILSPEEPKKHKRNLGRLFWVVVSDQNRAGITKTKSARVSPVTRRKTSFADGERSNSFVGTEEYLSPEMVRGDGHEFAIDWWALGILAYEMLYGSTPFRGKNRKDTFERILMMQPKFTGKPTPLTDLISKLLEKQPTRRLGYRLGASEVKEHPFFLGLRWELLTGVVRTPFIPSVELTTKTNGINIKEYLQKQREPPSPLDSPSCSISLTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIM9</accession>
    <name>A0A103YIM9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_011826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001042">
        <property type="protein sequence ID" value="KVI09814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIM9"/>
    <dbReference type="STRING" id="59895.A0A103YIM9"/>
    <dbReference type="Gramene" id="KVI09814">
        <property type="protein sequence ID" value="KVI09814"/>
        <property type="gene ID" value="Ccrd_011826"/>
    </dbReference>
    <dbReference type="OMA" id="TYTNQFD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119747" description="glucan endo-1,3-beta-D-glucosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI09814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="38528" checksum="223F9227D805A955" modified="2016-04-13" version="1">MGISKHLSLALLLLFLPAVYSIGVNYGTLGDNLPPPSQVAHFLKSRTIIDRIRIFDVNPDIIKAFANTGILVSVTLPNGEIPSLTDPRNARRWIDTNIKPFYPATKIHYICVGTEVLHWGPQNLIDNLVPAMKVLHAALVKEGFGDIKISTPHSLGILLSSDPPSNASFRPGWDVGSLAPMLEFLKETKSGFMVNPYTYFGYSPANANFCLFKPNAGLFDKATGITYTNQFDQLMDAVHVSMKKLGYPDVEIVVAETGWPSGGDPANVHANPVNAAAYIGGLMKKVNSGDGTPLMPGRKFETYIFALFNENLKGPSLDEKNFGLFRPDLTQVYNVGIEHAPLVIFFSDVSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ50</accession>
    <name>A0A103YJ50_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001031">
        <property type="protein sequence ID" value="KVI10028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ50"/>
    <dbReference type="STRING" id="59895.A0A103YJ50"/>
    <dbReference type="Gramene" id="KVI10028">
        <property type="protein sequence ID" value="KVI10028"/>
        <property type="gene ID" value="Ccrd_011572"/>
    </dbReference>
    <dbReference type="OMA" id="EKSACKP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13777" checksum="E4E7D8B9CDCC684F" modified="2016-04-13" version="1">MATKGGRKNLKRAVNDETLTLQPGQSIMQVVSLRGSNSIEVTDAKGEKALAFFPAKFQKSMPEIFKSTILDSSSGNTQRNRSTTREENELDSSEDDGLPPLEANTNRRIPVETQSDTGSDSEIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK93</accession>
    <name>A0A103YK93_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAWADEE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001010">
        <property type="protein sequence ID" value="KVI10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK93"/>
    <dbReference type="STRING" id="59895.A0A103YK93"/>
    <dbReference type="Gramene" id="KVI10598">
        <property type="protein sequence ID" value="KVI10598"/>
        <property type="gene ID" value="Ccrd_010987"/>
    </dbReference>
    <dbReference type="OMA" id="HEPAYDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032001">
        <property type="entry name" value="SAWADEE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36384">
        <property type="entry name" value="SAWADEE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36384:SF1">
        <property type="entry name" value="SAWADEE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16719">
        <property type="entry name" value="SAWADEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAWADEE" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="44190" checksum="262A957A08DDE795" modified="2016-04-13" version="1">MAISGDADADVSNYLEYRSKKDEAWYTSAVVLEDGKQLRVKFRDFVHSYYDEVFSVADFSTKSELQEFLHRFRRLSEPIEDNECSRVIADMMVCATYKGDGSVRFFDAIVDSRAMTMRKAPWSGWGTNTFTSTAKCSTGWKKTVVSPSASDGAFLVHYKEHTPEKCLCTYLLVWQHGPEEGNITATSIEDICLIMPGAVDPKVTDFAKIVKEKLGLVYKRPFLSRKTSSNETLDELQARRGGFYPPLSDHDRDLGGVKETGCHHYIILENLEKDLSPSSMMEFLHVQTSITPQAFLFPSLSAETYARGAVVVDSRPKLKRIYEFLSNPNHFIVSSSGRPWVIAEAVLRTGTFDTNLQSCQPLCCKGAKDVLYFGEIDGIKHNFQWRGPLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN25</accession>
    <name>A0A103YN25_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanylate kinase 1</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GMP + ATP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01000015">
        <property type="protein sequence ID" value="KVI12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN25"/>
    <dbReference type="STRING" id="59895.A0A103YN25"/>
    <dbReference type="Gramene" id="KVI12083">
        <property type="protein sequence ID" value="KVI12083"/>
        <property type="gene ID" value="Ccrd_009496"/>
    </dbReference>
    <dbReference type="OMA" id="WFLEVET"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="133"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="43126" checksum="11E90839DDB7C5C2" modified="2016-04-13" version="1">MGEAPAFYVDDMQGSFSNGFDLKLTGFETAIAVGNKTYVIGGNDDPTSNGVRIFDKSTGEWVIPTVLGTKPKALEGHLCVLLNQDKILIIKSNSNSNESVWFLEVDTLFIQDQKKKFDTEVVAWSKGVIGDAERPIVISGPSGVGKGTLINLLMKEFPTKFGFSVSHTTRAPREKEQNRVHYHFTKRSVMEEEIKAGKFLEFAAVHGNLYGTSIEAVDVVADAGKRCILDIDVQGARSVRDSSLEAIFIFVCPPSFEELEKRLRARGTETEEQIQKRLRNAKAELEQGNSPGLFDHILVNNDLEACYEQLKNILGISESMNIPPKTPNKAFDLSVDLSLSKINENILINCGPAEQRVVLDLSSMKGGAPARTRGLNMYALDPITDGANGCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTU2</accession>
    <name>A0A118JTU2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_006470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004933">
        <property type="protein sequence ID" value="KVH91507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTU2"/>
    <dbReference type="STRING" id="59895.A0A118JTU2"/>
    <dbReference type="Gramene" id="KVH91507">
        <property type="protein sequence ID" value="KVH91507"/>
        <property type="gene ID" value="Ccrd_006470"/>
    </dbReference>
    <dbReference type="OMA" id="TEWPEGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000262">
        <property type="entry name" value="cyclin-dependent kinase F-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000104">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH91507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="472" mass="53370" checksum="082DF7BECC5997FF" modified="2016-04-13" version="1">MERYKIIKEVGTGSFGVVWRALNKQNGEVVAIKKMKRKYYSWEECINLREVKSLRKMNHPNIVKLKEVIRENDILYFVFEYMECSLYQLMKDRLKLFLETEIRNWCFQVFQGLAYMHQRGYFHRDLKPENFLVSKDVIKIADFGLAREIISQPPYTEYVSTRWYRAPEVLLQSPTYGSAVDMWAMGAIMAELFTLRPLFPGSSEADEIYKICSVIGTPTESSWAEGLELASTISYQFPEVSSFLSVVIIIFCQLNAFFSSKRVPLSALIPSASEDGVDLIASLCSWDPCKRPTALEALQHPFFQRCYYVPPSLRPKATTIGRTPPSGVSSGRRGVEQKCSNKRYPLPNSKPVGNIITTSGVQRRLEMNSNSNKQDGVKEKMNKKCARQAAAAAPPPKYQPPMKNNNPRGMYMGKGRGGVGMGETVEKLGNMTIGSARQQQQQQQQMMRMKGGNGNHVLFTGRSQGYSSKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUJ4</accession>
    <name>A0A118JUJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004915">
        <property type="protein sequence ID" value="KVH91627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUJ4"/>
    <dbReference type="STRING" id="59895.A0A118JUJ4"/>
    <dbReference type="Gramene" id="KVH91627">
        <property type="protein sequence ID" value="KVH91627"/>
        <property type="gene ID" value="Ccrd_006347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF338">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE, NON-RECEPTOR JAK_TYK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="74" mass="8563" checksum="06D5D3DEBDDE60D2" modified="2016-04-13" version="1">MYEYASRGSLDRHLSDATLMWMQRLRICLASARGLSYLHDPKGTQHRVLHCDIKSLTSYGMRIGMLSTLHYNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV03</accession>
    <name>A0A118JV03_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004802">
        <property type="protein sequence ID" value="KVH92921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV03"/>
    <dbReference type="Gramene" id="KVH92921">
        <property type="protein sequence ID" value="KVH92921"/>
        <property type="gene ID" value="Ccrd_005041"/>
    </dbReference>
    <dbReference type="OMA" id="NFEPEAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="13332" checksum="50AF3696D3320207" modified="2016-04-13" version="1">MENKSTKKEINRGAWTAEEDEKLAEAIQIHGPKKWTAIAAKAAEMKEEDHITPIDEHGVECSKVIFNVDEFFDFSNEDPTTLDWVNRNRPTQNKTNNFEPEANGISSIVRLYASRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVM3</accession>
    <name>A0A118JVM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane receptor, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004762">
        <property type="protein sequence ID" value="KVH93477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVM3"/>
    <dbReference type="Gramene" id="KVH93477">
        <property type="protein sequence ID" value="KVH93477"/>
        <property type="gene ID" value="Ccrd_004473"/>
    </dbReference>
    <dbReference type="OMA" id="WIAYEVY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159729" evidence="8">
        <location>
            <begin position="34"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="256"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="559" mass="62489" checksum="E7E696400B66C3AF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVR6</accession>
    <name>A0A118JVR6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVR6"/>
    <dbReference type="STRING" id="59895.A0A118JVR6"/>
    <dbReference type="Gramene" id="KVH92935">
        <property type="protein sequence ID" value="KVH92935"/>
        <property type="gene ID" value="Ccrd_004972"/>
    </dbReference>
    <dbReference type="OMA" id="AFDHIDM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24095">
        <property type="entry name" value="ASKHA_NBD_HSP70_AtHsp70-14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000031">
        <property type="entry name" value="Heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH92935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="796" mass="88484" checksum="E91B96FC8EF70143" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW40</accession>
    <name>A0A118JW40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004400">
        <property type="protein sequence ID" value="KVH95062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW40"/>
    <dbReference type="STRING" id="59895.A0A118JW40"/>
    <dbReference type="Gramene" id="KVH95062">
        <property type="protein sequence ID" value="KVH95062"/>
        <property type="gene ID" value="Ccrd_002858"/>
    </dbReference>
    <dbReference type="OMA" id="PVESDMH"/>
    <dbReference type="OrthoDB" id="1918918at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF111">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15951" checksum="405F2D5A876AAD11" modified="2016-04-13" version="1">MADINTAETPPVYRGIRMRDGKWMSETRDPLTNTRYWLGTYATREKAAIAYDAAVYYFRGQGASLNFPHMATVLPRPPTSSKEDVRKACKKASLLLEPSIGTGSSSLPTHIQLLPTQIQAIRDSPLDCYETWMEANCTYVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWI6</accession>
    <name>A0A118JWI6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_003626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWI6"/>
    <dbReference type="Gramene" id="KVH94272">
        <property type="protein sequence ID" value="KVH94272"/>
        <property type="gene ID" value="Ccrd_003626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH94272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10908" checksum="34A18286377345C4" modified="2016-04-13" version="1">MEDQRNNLGLGNKSRRRPEGLMEISDHRSDDNVAGAGTGFFYVKKSSTRRVQTKLEFRKYDPHASTKKQCHTKSTSRPLCAIAIDLLGLSEVVDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWJ7</accession>
    <name>A0A118JWJ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWJ7"/>
    <dbReference type="Gramene" id="KVH94781">
        <property type="protein sequence ID" value="KVH94781"/>
        <property type="gene ID" value="Ccrd_003155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="154" mass="17401" checksum="2BC949224ED22794" modified="2016-04-13" version="1">MGSPVLFYCYYDKGTDHRRGHFRPHRVAVIIFMLLLLVNRLLLISLFLSPQSHIALCHLLNFSSMVFVRRFGLPQLVMQWMEDSGVQPSVEMYQSILAFAQSSGREYSVIIQDRVGRSMPRMVHIPATVTKNEESSSTTTGDGVAGRLLCLPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX33</accession>
    <name>A0A118JX33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_002577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004392">
        <property type="protein sequence ID" value="KVH95334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX33"/>
    <dbReference type="STRING" id="59895.A0A118JX33"/>
    <dbReference type="Gramene" id="KVH95334">
        <property type="protein sequence ID" value="KVH95334"/>
        <property type="gene ID" value="Ccrd_002577"/>
    </dbReference>
    <dbReference type="OMA" id="NEPFIQR"/>
    <dbReference type="OrthoDB" id="1736050at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009788">
        <property type="term" value="P:negative regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044246">
        <property type="entry name" value="ZFP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287">
        <property type="entry name" value="C2H2 AND C2HC ZINC FINGERS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="312" mass="34064" checksum="5BD0BB57854C02D0" modified="2016-04-13" version="1">MEEEHKSEPCPSEASSISAEGESLKNKTLDSKALAEGSSDIQLNRRVGNQSSSRAFLDIKFSNTEDKRLELNLFNPSKVAAEGATSSQVSESSKETTREKSRVFSCNYCKREFSTSQALGGHQNAHKQERQIAKRRQMEVPPYGHLGPPPPHYGNFTYYPSFPNLTSASISSNRSSLGIRNEPFIQRSPSWSTSQFNYRYASVGHHDQFTTGLPYFDRPKMLEGFQGNITNNSDCYGSPAVATASSSFKFEGVPGAAHDFFGPSSGNGNPTPALENGIEGEISANNLLALGVVHPENDQDGSTVDLDLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXK8</accession>
    <name>A0A118JXK8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004284">
        <property type="protein sequence ID" value="KVH96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXK8"/>
    <dbReference type="STRING" id="59895.A0A118JXK8"/>
    <dbReference type="Gramene" id="KVH96492">
        <property type="protein sequence ID" value="KVH96492"/>
        <property type="gene ID" value="Ccrd_001420"/>
    </dbReference>
    <dbReference type="OMA" id="FEMITYE"/>
    <dbReference type="OrthoDB" id="1858506at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17360" checksum="DC69B82EABEC4A67" modified="2016-04-13" version="1">MTSASIEIEIPSSYPADKVFKVFSDFDNIAPKVNPDVFKSIETIEGNGDVGTKKIFTFGDAVPFTSGKYKVDAIDTSNFSYSYSFFDGDCLMGILDSITHHIKVVPCDGGSKFKQTVIYNCKSSDKPSEEILKAEKEIYEKTYKAIEAYGAAHPESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY26</accession>
    <name>A0A118JY26_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, A20-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in environmental stress response.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003865">
        <property type="protein sequence ID" value="KVH97062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY26"/>
    <dbReference type="STRING" id="59895.A0A118JY26"/>
    <dbReference type="Gramene" id="KVH97062">
        <property type="protein sequence ID" value="KVH97062"/>
        <property type="gene ID" value="Ccrd_000842"/>
    </dbReference>
    <dbReference type="OMA" id="CFNATTT"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4770:FF:000006">
        <property type="entry name" value="Zinc finger A20 and AN1 domain-containing stress-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF22">
        <property type="entry name" value="ZINC FINGER A20 AND AN1 DOMAIN-CONTAINING STRESS-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18342" checksum="793C28CBD0D1D8AF" modified="2016-04-13" version="1">MAQRTEKEETEFKVVPETLTLCVNNCGVVGNPATNNMCQKCFNATTTASSTTSQRARSRSSSSRPASPRDVSVDLVLDRTIVALDEESKEKERTDAVVIKKEVNRCSGCRKRVGLTGFRCRCGDLFCAEHRYSDRHDCSYDYKTAGREAIARDNPVVKAAKIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ96</accession>
    <name>A0A118JZ96_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003417">
        <property type="protein sequence ID" value="KVH99729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ96"/>
    <dbReference type="Gramene" id="KVH99729">
        <property type="protein sequence ID" value="KVH99729"/>
        <property type="gene ID" value="Ccrd_022044"/>
    </dbReference>
    <dbReference type="OMA" id="CHAAENS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF66">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="19390" checksum="0F4D36B5E64CDA97" modified="2016-04-13" version="1">MMKQRHKVERESNIREVGEGIEYLHTGCVPSIIHRDLKTSNIFLDDNMTAKVSDFGLSKLAVDGNSHAKLHIENGGIQRIIDPALRDEYDVQSMWKTAEKALMCVQPHANMRPSMSEVIKEIQDAISIERGVNGGSCNEILRSSFHSSLNMGLLDAGIDPYLSFHDSITLPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZR5</accession>
    <name>A0A118JZR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-amylase</fullName>
            <ecNumber evidence="4">3.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003634">
        <property type="protein sequence ID" value="KVH99190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZR5"/>
    <dbReference type="STRING" id="59895.A0A118JZR5"/>
    <dbReference type="Gramene" id="KVH99190">
        <property type="protein sequence ID" value="KVH99190"/>
        <property type="gene ID" value="Ccrd_022591"/>
    </dbReference>
    <dbReference type="OMA" id="PFVRKMS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016161">
        <property type="term" value="F:beta-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005983">
        <property type="term" value="P:starch catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001554">
        <property type="entry name" value="Glyco_hydro_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352">
        <property type="entry name" value="BETA-AMYLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352:SF37">
        <property type="entry name" value="INACTIVE BETA-AMYLASE 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01373">
        <property type="entry name" value="Glyco_hydro_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00750">
        <property type="entry name" value="BETAAMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="574" mass="65922" checksum="47553FBD275E23A4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Z3</accession>
    <name>A0A118K0Z3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5-AMP-activated protein kinase, beta subunit, interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Z3"/>
    <dbReference type="STRING" id="59895.A0A118K0Z3"/>
    <dbReference type="Gramene" id="KVI02068">
        <property type="protein sequence ID" value="KVI02068"/>
        <property type="gene ID" value="Ccrd_019635"/>
    </dbReference>
    <dbReference type="OMA" id="NGYEVDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043554">
        <property type="entry name" value="KINB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316:SF8">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="158"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="250" mass="28282" checksum="03342B64D5AC490E" modified="2016-04-13" version="1" fragment="single">MGNVSGREEKSSREYYMECGQAQNLVILTSKLPQNPNMIMQIERGGFNESTRNYGSASPEKSIPAVISWIHGGTQVAIEGSWDDWKIRELLEGSGSGFSIFKVLKAGVYHYRFVVDGQWIYDPDLPHECDHLGNVFNVLDLKDNYPENTERDQEPECPSSPISSYNNPAITLDDFDKKLPEMPPLLQQMPLNQPSSSKNPQRDLQKPLSANLNHLYIKRDGGSQPVVALSSSQRFRTKFVTNVLYKPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1Y6</accession>
    <name>A0A118K1Y6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002348">
        <property type="protein sequence ID" value="KVI03495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1Y6"/>
    <dbReference type="Gramene" id="KVI03495">
        <property type="protein sequence ID" value="KVI03495"/>
        <property type="gene ID" value="Ccrd_018208"/>
    </dbReference>
    <dbReference type="OMA" id="IIMKQIC"/>
    <dbReference type="OrthoDB" id="1921707at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056682">
        <property type="entry name" value="DUF7780"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34960">
        <property type="entry name" value="EMB|CAB68146.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34960:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25002">
        <property type="entry name" value="DUF7780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7780" evidence="2">
        <location>
            <begin position="101"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="51018" checksum="C09849ABBB1BDD7E" modified="2016-04-13" version="1">MGIFLVFFPEEHFNSSTPTSSLSPFKSATIKGFLKRTNSSHIFTRAQSTISICALLIFLTFLLFTLSSFEPNNDFISNHHNLHQYRRYLSQNRPKPRSHSPALQGLGTLYTRGTTAMNELVICHVSESVTTKELKLFMRAFHRSGLAAKSDLLFIFNSISTIDSFDDLIQEENDLFLKLVHRYKTELGNGSKVVDFPASFDVTRFVKPGKEAHKGEPIWGRKMKSNNSSFSNDDNETEFTRTSYGSVVGFGIGELDPENSLSGFLDHVPMSLRRWASYPMVLGRVRRKFKHIILVDVKELLLVGDPLGRVKNHSPESIFLSSIPPTPKHGRKNTKPHRKTINPALILGGERGVRRLSAAMLTEIVRTTTRQQHNKKKNSVAESALLSQLVANEFLQKSIRFITATESIQDPSSLSGVSLANQIVVRRGNSNLDIGAVMMKHICSFPLDSSVYTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K220</accession>
    <name>A0A118K220_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Agenet-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K220"/>
    <dbReference type="STRING" id="59895.A0A118K220"/>
    <dbReference type="Gramene" id="KVI03678">
        <property type="protein sequence ID" value="KVI03678"/>
        <property type="gene ID" value="Ccrd_018025"/>
    </dbReference>
    <dbReference type="OMA" id="DEATENW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20405">
        <property type="entry name" value="Tudor_Agenet_AtDUF_rpt1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054292">
        <property type="entry name" value="DUF7028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF11">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE CHROMATIN REGULATOR PHD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22970">
        <property type="entry name" value="DUF7028"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="741"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1149" mass="132943" checksum="FB122EEBA97B0D7C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K340</accession>
    <name>A0A118K340_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001877">
        <property type="protein sequence ID" value="KVI05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K340"/>
    <dbReference type="STRING" id="59895.A0A118K340"/>
    <dbReference type="Gramene" id="KVI05342">
        <property type="protein sequence ID" value="KVI05342"/>
        <property type="gene ID" value="Ccrd_016323"/>
    </dbReference>
    <dbReference type="OMA" id="SQWPDLK"/>
    <dbReference type="OrthoDB" id="1752214at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038793">
        <property type="entry name" value="AGP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36549">
        <property type="entry name" value="LYSINE-RICH ARABINOGALACTAN PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36549:SF3">
        <property type="entry name" value="LYSINE-RICH ARABINOGALACTAN PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159908" evidence="2">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="250" mass="25078" checksum="E3C2BFA0803A4F58" modified="2016-04-13" version="1">MLWITSILACLCLLVVISNGQGPAASPSNTPATVTTPVAPTQPPPATPVAPTQPPPATPLSSPSPKTPPVSSPTVPPPQIPPPQPPVSPPVASPTTPPPSLPSPTPPPVVSPPALPPAVPPPKVSPAPATPPPAPTPPPPAPAPPPPSPAPAPVTLPPAPTPDMSPSPAPAPRHHKRRRHKHKKHHAPAPAPVAKSPPAPPTATDSDDTTPAPAPTLDLSNGRTLFQQEGRFGTQVGTGFIIAVLLVLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3Z8</accession>
    <name>A0A118K3Z8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001751">
        <property type="protein sequence ID" value="KVI06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3Z8"/>
    <dbReference type="STRING" id="59895.A0A118K3Z8"/>
    <dbReference type="Gramene" id="KVI06692">
        <property type="protein sequence ID" value="KVI06692"/>
        <property type="gene ID" value="Ccrd_014953"/>
    </dbReference>
    <dbReference type="OMA" id="IKHEDCI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="33280" checksum="994FA3974AD08F69" modified="2016-04-13" version="1">MEEIKWLHFWLSRGQILCKAHAQSYLCKGLVSVQRYWEALEIINSSLKLAHNTLTTDKKEELRSLGAQIAYNIDGPTNGWDCARYIVSQNPYSFAAWNCYYKIMSRLDKHSKFLHEKSIKHEDCIPVNLIKGHHFTMISQHQAAARYYLKAYKLMPENALINLCVGTALINLALGLRLHNKHQCVLQGLAFLYNNLRLSGNSQEALYNLARAYHHVGLITLAVTYYEKVLAIHQKDHPIPKLPNDGSEAMDDLKPGYCDLRREAAYNLHIIYKSSGAMGLARQVLRDHCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5N4</accession>
    <name>A0A118K5N4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5N4"/>
    <dbReference type="STRING" id="59895.A0A118K5N4"/>
    <dbReference type="Gramene" id="KVI09363">
        <property type="protein sequence ID" value="KVI09363"/>
        <property type="gene ID" value="Ccrd_012267"/>
    </dbReference>
    <dbReference type="OMA" id="AYESPMA"/>
    <dbReference type="OrthoDB" id="1929763at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35718">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35718:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159993" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13050" checksum="9985FED68D7EE0A8" modified="2016-04-13" version="1">MTPRPSLLLVLMLLITTHSRAQGRAPHGLAHEKLVAFSPSAYDFFHPNTQPSSPLPLAATVQSSLAHESRAENNKGGGKVGAGGIAAIIFGFVFALLLAMGVYYVATTRRANLSRNNTVIPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5S1</accession>
    <name>A0A118K5S1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001058">
        <property type="protein sequence ID" value="KVI09510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5S1"/>
    <dbReference type="STRING" id="59895.A0A118K5S1"/>
    <dbReference type="Gramene" id="KVI09510">
        <property type="protein sequence ID" value="KVI09510"/>
        <property type="gene ID" value="Ccrd_012111"/>
    </dbReference>
    <dbReference type="OMA" id="MLPDDTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF200">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 HOMOLOG E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="241"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="514"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="805" mass="89655" checksum="25805318348FB669" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L0</accession>
    <name>A0A118K6L0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000994">
        <property type="protein sequence ID" value="KVI10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L0"/>
    <dbReference type="STRING" id="59895.A0A118K6L0"/>
    <dbReference type="Gramene" id="KVI10833">
        <property type="protein sequence ID" value="KVI10833"/>
        <property type="gene ID" value="Ccrd_010774"/>
    </dbReference>
    <dbReference type="OMA" id="NDPVWHI"/>
    <dbReference type="OrthoDB" id="2012654at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006873">
        <property type="entry name" value="DUF620"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31300">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31300:SF2">
        <property type="entry name" value="LIPASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04788">
        <property type="entry name" value="DUF620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="467" mass="50825" checksum="A6969FFA396BBCBA" modified="2016-04-13" version="1">MERKQGFFSTLRDEVVSGLSPARSRARSPARSGSPMSGLLRLKPKQSPYQESFVGRSGSLSGETLAPLIEGPDPAASELGESKRSGSVIGNWVKGHLYRAPSITASMAYKQRSDLRLLLGVMGAPLAPVNVSSTDPLPHLSIKDTPIETSSAQYILQQYTAASGGQKLQNSIKNAYAMGKVKMVASEFETASRVVKNKHAAKGAESGGFVLWQMNPDMWYVELAVGGSKVHAGCNGKLVWRHTPWLGAHTAKGPVRPLRRALQGLDPRTTASMFVDAKCIGEKKINGEDCFILKLCADPQTLKARSEGPAEIIRHVLFGYFSQKTGLIVHMEDSHLTRIQTNGGDAVYWETTINSFMDDYRSVDGMMIAHSGRSVVTLFRFGEMAMSHTKTRMEEVWTIEEVVFNVPGLSMDCFIPPADLRSGSISESSELPQGGERGKAAIAIAAHRAKVAALEKGQDNVVWKMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7D3</accession>
    <name>A0A118K7D3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="LEKV01000018">
        <property type="protein sequence ID" value="KVI12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7D3"/>
    <dbReference type="STRING" id="59895.A0A118K7D3"/>
    <dbReference type="Gramene" id="KVI12047">
        <property type="protein sequence ID" value="KVI12047"/>
        <property type="gene ID" value="Ccrd_009533"/>
    </dbReference>
    <dbReference type="OMA" id="YEGDDYH"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000522">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="22492" checksum="46965104F29DE96C" modified="2016-04-13" version="1">MGSNHQGIAVVIMGVSGAGKSTVGEMLGKALNCSYVDADDFHPQSNKGKETYSDISDKTEKMKNGIPLSDEDRIPWLERLRSIVNASFVSGKTVILGCSALQKHYRDILRSADPNYEGSRGHICAVKFVLLEVGVKVLMDRVKKRAAEGKHFMPPQLLQSQLDLLQIDASEGIFTVPPIKLDVHSLKLLSASPTTLLPARIFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB70</accession>
    <name>A0A124SB70_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_008293</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005158">
        <property type="protein sequence ID" value="KVH89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SB70"/>
    <dbReference type="Gramene" id="KVH89712">
        <property type="protein sequence ID" value="KVH89712"/>
        <property type="gene ID" value="Ccrd_008293"/>
    </dbReference>
    <dbReference type="OMA" id="QDMDASY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18660">
        <property type="entry name" value="CD1_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="409"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="624"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="932"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1441"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1653"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1481"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1491"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1719" mass="195668" checksum="44179DF1181881EA" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDE2</accession>
    <name>A0A124SDE2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004258">
        <property type="protein sequence ID" value="KVH96655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDE2"/>
    <dbReference type="STRING" id="59895.A0A124SDE2"/>
    <dbReference type="Gramene" id="KVH96655">
        <property type="protein sequence ID" value="KVH96655"/>
        <property type="gene ID" value="Ccrd_001254"/>
    </dbReference>
    <dbReference type="OMA" id="HPYSDLI"/>
    <dbReference type="OrthoDB" id="549883at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010820">
        <property type="entry name" value="DUF1421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31805:SF16">
        <property type="entry name" value="FORMIN-LIKE PROTEIN (DUF1421)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31805">
        <property type="entry name" value="RECEPTOR-LIKE KINASE, PUTATIVE (DUF1421)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07223">
        <property type="entry name" value="DUF1421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1421" evidence="2">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="55954" checksum="2FC882DD6DC7074A" modified="2016-04-13" version="1">MDSGSSKGFDFASDDILCSYEDYTNQDNSNGNHSDSAIGTNSSKEFHKSRMSRPSVFPASSYSPPDDSGNQDVVIAAVERSMKKHSDNLMRFLEGLSSRLSQLELYCYNVDKSIGEMRSDLARDHGESEAKLKFLEKHLQEVHRSVQIIRDKQELADTQKELAKLQLAQKESSAGHDSQKSGETSPVPSDTKRNDNAAEGHGQQLALALPHQVAPLPAPQPAAPQPQMAPQPMSQSQTYYLSPSQLPNIPAPTQLTQNHYLQSDPHYQNPPPQRSQVSQPQPQPQPQVHSLPQYQQQWAQQVSQQVQPPQPAVRPSSPQVFPPYLQSQQVNPSTPETLPNSMPMQMPYSGIPQPSSSQAMTYAFGGPGRTPQQPSQHLKPGFGGQQNDGYVAGGHSNVPQGNTYMMYDSEGGRVPHASHPTHFSQSVYPPNPQQNSGSSMMARPPPQFMRSHPYNELIDKLGSMGFRGEHVISVIQRLEENGQTVDFNTVLDRLNVHPSGGSQRGWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF61</accession>
    <name>A0A124SF61_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF61"/>
    <dbReference type="STRING" id="59895.A0A124SF61"/>
    <dbReference type="Gramene" id="KVI02222">
        <property type="protein sequence ID" value="KVI02222"/>
        <property type="gene ID" value="Ccrd_019514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="55763" checksum="7730CAE29D3186BC" modified="2016-04-13" version="1">MSSENTLPLITKAEGGGGDGSWWKKVLDWDEAKDQILFSLPMILTNVAYYCIPLVSVMFAGHLGEVELAASNLANSWATVTGLSFMVGLSGALETLCGQGFGAKLYRMLGIYLQASCWISISFSILISVIWFFTEPILILLHQDPQIAKLAALYIKYLIPGLFAYGLLNNMLRFLQTQSVVAPLVLCSVAPLILHFGIAYVLVQRTSLGFVGAPLAASISLWISAIMLALYVLFDKKFKETWHGFSMESFRHVFATLKLALPSAAMVCLEYWAFELLVLLAGIMPNSEITTSLIAMCVNTEAIAYMLTYGLSAAASTRVSNELGARNIDKAKNAMGVTLKLSVLLALIVVLALGFGHDIWAGFFSSSPVIINHYASMTPLGGEGVRLATSGCVHQLRNVLSYRHADCSCPRVSRETICEGVVDWLNMRSGQSDRWSATTHVSQEMDASGTRLKQLFCRHGSLEYQHPRSSVDKLQNYPLPLFCGSTYLLREVTRDLKEPNACFLGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGG0</accession>
    <name>A0A124SGG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001840">
        <property type="protein sequence ID" value="KVI06286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="398" mass="44242" checksum="4973ABD18C28A4BC" modified="2016-04-13" version="1">MLSSTTLHHFCKLEHVLASTTLHHFCTIFIFALLAKKSAHFTISFVPNLSFMHLQNNVLASNIVICVVFYICHQISGICRCKNVADGTSNEKKMIEAGITPNAVTWSSLISACAKAGLVDQAFVLFEEMVLANCMPNSQCCNVLLYACVKAFQYDRAFRLFQSWKRNSFQMAFGDNYIANRQSLSKGGLQIDMKVPFKPTTSTYNVLMKACGTDHLRAKALMDEMKRFGLXPNHISWSTLIGVYGGSGDVKSAVQVKSRSEVLMQILETMRESGVQPDVVAYTAAIRVTYNTLLRARTRYGSLKEVQQCLSIYQDMRKAGNIALKTSALGKGIGIIASLVGVISSLHPNPTEPDFHVYTVLHVQIPTEIRINVENPFSPRSNLDKKTPPPEDQQFCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHI4</accession>
    <name>A0A124SHI4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011951</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001050">
        <property type="protein sequence ID" value="KVI09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHI4"/>
    <dbReference type="STRING" id="59895.A0A124SHI4"/>
    <dbReference type="Gramene" id="KVI09658">
        <property type="protein sequence ID" value="KVI09658"/>
        <property type="gene ID" value="Ccrd_011951"/>
    </dbReference>
    <dbReference type="OMA" id="PMGRHQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000435">
        <property type="entry name" value="SEC12-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF2">
        <property type="entry name" value="SEC12-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="365" mass="40471" checksum="6AD0033981E5C934" modified="2016-04-13" version="1">MDGGVAAEQGTVTCASWIRRPEDAHLVALGKSKHGDLPASFQIFSFDRLTTSLSSSPSVTFEFEDGCDPVSLAVHPSGDDIVCSTTKGGCRLFQLYGQEKNVKLLAKNLKPLEDVGAQRCLAFSPDGSRFATGGVDGHLRIYEWPSMRVIVDESKAHKSFNDMDFSLDSEFLASTSTDGSARIWNTSDGVPVNSLTRNSDEKIELCRFSKDGTKPFLFCTVQKGNKSITVVWDISTWNRIGFKRLLRKPACVMSISLDGKYLAQGSKDGDVCVVAVKKMEVCHWSKRLHLGFSVTSLEFCPKWQIYLVLIGLFLASAVLFYIFFETSDLFWNFPLGRDQPARPKLGSFLPDPQSDDQNMWGPVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI48</accession>
    <name>A0A124SI48_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_010007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000076">
        <property type="protein sequence ID" value="KVI11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI48"/>
    <dbReference type="STRING" id="59895.A0A124SI48"/>
    <dbReference type="Gramene" id="KVI11581">
        <property type="protein sequence ID" value="KVI11581"/>
        <property type="gene ID" value="Ccrd_010007"/>
    </dbReference>
    <dbReference type="OMA" id="WEYDESA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF216">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP2-EREBP FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="28913" checksum="C6B93DAAE59E36E6" modified="2016-04-13" version="1">MAEALNSETESTTTTISDPLSKETGLKDPNRKWVNRSRKYAEDDDGNSRSSKATKTNSKHPVYRGVRKRAWGKWVSEIREPKKKSRIWLGTFSDPEMAARAHDVAALSIKGKSAILNFPELSDLLPRPVSCSPCDIQAAATKAASMVHLNHTTTATPRCTPSTSATSTCSATSSMMLEEVSMWKPQSEELSEIVELPSVGEGFDHSVDFVFVDSGWDYYSSPPPWAEDGDGDGDGGYLGGEPSYVTPSFSGSVGSFFFDASSWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103R5W8</accession>
    <name>A0A103R5W8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007878">
        <property type="protein sequence ID" value="KVG61807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103R5W8"/>
    <dbReference type="STRING" id="59895.A0A103R5W8"/>
    <dbReference type="Gramene" id="KVG61807">
        <property type="protein sequence ID" value="KVG61807"/>
        <property type="gene ID" value="Ccrd_026320"/>
    </dbReference>
    <dbReference type="OMA" id="FMGGNDP"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVG61807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="340" mass="38583" checksum="049F32EDB938A521" modified="2016-04-13" version="1">MAHGGYDKRRVAGRKPVNKATNHRPKALGVEKKPKAKLGSLKRQIRSTERLLRKDTRPEVKEALTKKLEGLKNQQQVQDNLALERKIFLRDRKIKFFERRKVERRIRRLEKQQRASSGQAQEPEIVEQLSRLKEDLEYIRFFPKTEKYVSLFKKGDNMDTVDKRNSLRTQIKANIAAAVASGKDLEETGSDDDGLDLSEDDFFVSGSSSDEADADDEWTDKSAREQASSASGKAASGMSSDERNQRHISARALMPPPRASNGSSAVHVKSRYSNSFNKNSSFRRRDMSSSSNTSTSVDRPSFENRRPYIHTGNSSSNLSSNSDARKPKRKRRPKKKKQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103TTB1</accession>
    <name>A0A103TTB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007032">
        <property type="protein sequence ID" value="KVH22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103TTB1"/>
    <dbReference type="STRING" id="59895.A0A103TTB1"/>
    <dbReference type="Gramene" id="KVH22981">
        <property type="protein sequence ID" value="KVH22981"/>
        <property type="gene ID" value="Ccrd_025880"/>
    </dbReference>
    <dbReference type="OMA" id="YKFCVAS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15795">
        <property type="entry name" value="PMEI-Pla_a_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000002">
        <property type="entry name" value="Putative invertase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034088">
        <property type="entry name" value="Pla_a_1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357">
        <property type="entry name" value="OS02G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357:SF17">
        <property type="entry name" value="PECTINESTERASE INHIBITOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118112" evidence="4">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="187" mass="20957" checksum="0B2DE99CC7092A07" modified="2016-04-13" version="1">MSSSFHSCFSLSLFLFPFIFFSVNGQNIIYDTCKTSSQQDPNVNLQFCTTSLQAAPASHCADLKGLGMMSIRLTRYNLTDTRCYIKQLLKKNTKKLDPYIKSCLDDCFELYSDAIPGIKQAMKSYNSKRYFDANVQISSVMDATTTCEDGFKQKKGVVSPLTKKNDMTFQLSAMSLSIMNILQSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103V0I9</accession>
    <name>A0A103V0I9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectinesterase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_025737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006823">
        <property type="protein sequence ID" value="KVH45066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103V0I9"/>
    <dbReference type="STRING" id="59895.A0A103V0I9"/>
    <dbReference type="Gramene" id="KVH45066">
        <property type="protein sequence ID" value="KVH45066"/>
        <property type="gene ID" value="Ccrd_025737"/>
    </dbReference>
    <dbReference type="OMA" id="CMATITK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051955">
        <property type="entry name" value="PME_Inhibitor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080:SF15">
        <property type="entry name" value="INVERTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118381" evidence="2">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="3">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH45066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="198" mass="21617" checksum="C2A535A9321575E0" modified="2016-04-13" version="1">MEQTKFLSLFSLIFMAMAILVVVPASSSSTKTTKTYTNFVKTSCNSTTYPSICLTYLLPYATAVKSNPQRLVKHALSATLKSAATTRVTVLKLAKAKNITKGDAAVLKDCVEEIQDSIDEIKNSLKAISSLKSSANKKFVISNAQTWTSAAITDENTCIDEFSEENVSPAIKSKIRNSIIRIARLSSNALYLINHLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103V0J7</accession>
    <name>A0A103V0J7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006822">
        <property type="protein sequence ID" value="KVH45088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103V0J7"/>
    <dbReference type="STRING" id="59895.A0A103V0J7"/>
    <dbReference type="Gramene" id="KVH45088">
        <property type="protein sequence ID" value="KVH45088"/>
        <property type="gene ID" value="Ccrd_025736"/>
    </dbReference>
    <dbReference type="OMA" id="QCTIVIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH45088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="16491" checksum="E0C62664204AE0F8" modified="2016-04-13" version="1">MSYLAGNKVNNIDVVYTSWQNLKKTPSMDVGQVGFHNNKAVRTVRVEKRINEVVNRLNRTKVERKPDLKAEREAVNAAERAERKQQLRDKKRREEMERLEKERQAEVRSYKNLMVADKMTSNKDIASTHKSLQELEEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VSZ1</accession>
    <name>A0A103VSZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006669">
        <property type="protein sequence ID" value="KVH59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VSZ1"/>
    <dbReference type="STRING" id="59895.A0A103VSZ1"/>
    <dbReference type="Gramene" id="KVH59583">
        <property type="protein sequence ID" value="KVH59583"/>
        <property type="gene ID" value="Ccrd_025661"/>
    </dbReference>
    <dbReference type="OMA" id="QDMFEDD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="23924" checksum="417F89E2F9D42EF0" modified="2016-04-13" version="1">MGRKDGLEKHGYNDALRTSKREMAVATRGIEREIASLQMEEKKLVAEIKKTAKIGNEAATKILARQLVRLRQQITNLQGSRAQIRGVATHTQALYANTSISTGMKGATKAMVAMNKEMAPAKQAKVIKEFQTQSAQLDMTIEMMSESIDETLDKDEAEEETEELTNQVLDEIGVGIASQLSSAPKGRIGPKKVDNAVPSSVSNDVDDLEKRLASLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCS1</accession>
    <name>A0A103XCS1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005434">
        <property type="protein sequence ID" value="KVH88365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCS1"/>
    <dbReference type="STRING" id="59895.A0A103XCS1"/>
    <dbReference type="Gramene" id="KVH88365">
        <property type="protein sequence ID" value="KVH88365"/>
        <property type="gene ID" value="Ccrd_024002"/>
    </dbReference>
    <dbReference type="OMA" id="SNAHEIP"/>
    <dbReference type="OrthoDB" id="682511at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16987">
        <property type="entry name" value="ANTH_N_AP180_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF19">
        <property type="entry name" value="OS08G0467300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="10">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="45565" checksum="13F81384557221E0" modified="2016-04-13" version="1">MWKRASEALKDQCSLFITSLAPCSVLRNPDIEADVIKATSHDDSHIDYVSAQRIFMWIRVSGDYVNPVMLSLSSRMKRTRSWTVALKGLMLLHGVFTCKVPAIQKIGQLPFDLSNFKDRNPDMRHHEAFIRAYYTYLEKKSLFMFHHLQEQEEEKRKKEKDLSEMEKKQKQSSMMQDLEWIQKLQGLLDVLLKIRPHRDSMMNVLVLEAMDCIMIEIFDIYSRICNGIAAVLVRIYTTNTTKAEATKVMSILKKAMVQGEDLSQYINLCSDLGVMKAKKFPKIHRIPEEDIRELEHIIKKDSDQPKTKQIIRKDDEKSKKTVEQKESKGDSETTITVNWEFVEEERKSNHDPDPTLPATENDAGIHPLAKEAPDLMTYDSEGMKSDEDPPIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD32</accession>
    <name>A0A103XD32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005410">
        <property type="protein sequence ID" value="KVH88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD32"/>
    <dbReference type="Gramene" id="KVH88428">
        <property type="protein sequence ID" value="KVH88428"/>
        <property type="gene ID" value="Ccrd_026832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031421">
        <property type="entry name" value="DUF4666"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33730:SF4">
        <property type="entry name" value="OS05G0542732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33730">
        <property type="entry name" value="OS05G0542732 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15697">
        <property type="entry name" value="DUF4666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15264" checksum="5ACC03D76AA5FC9D" modified="2016-04-13" version="1">MLVQEGKHKKILHATRTQKLKTSLRSAMATLKRSEKSFRRQGSSGSVWDGKKLTEGVNQLMRKEGNCEDHRQLRPCYSISGGVTEGSLSNVEPRVYARSLSTPSPIVGDSGKLLNDVMRLILHDDGGGGWLNDCIESGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD78</accession>
    <name>A0A103XD78_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005364">
        <property type="protein sequence ID" value="KVH88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD78"/>
    <dbReference type="STRING" id="59895.A0A103XD78"/>
    <dbReference type="Gramene" id="KVH88592">
        <property type="protein sequence ID" value="KVH88592"/>
        <property type="gene ID" value="Ccrd_026355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="25660" checksum="5A9C9D13F5425FF9" modified="2016-04-13" version="1">MEVGVGNSPETGGVAMEFPVFDGAELSSPPTVPPRLRRRLTETKSSGSPSSVEEIEAKLRNADLRRQKFYESLSSKARPKRRSPQYANGHNLGQRLEAKLQAAEQKRINRIEENIGKVQSEIRSLKKDMQNVKHQLNRRGKSGSEEFFEGHSGYFRGKNDSIRRVIPRLVRQRSSRTTSATTTSTTVGSCQCNAVALEFLFLSTLTTSNTRGCEEEDGGLNEEAGAGSIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDR0</accession>
    <name>A0A103XDR0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine aminopeptidase/peptidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer (dimer of homotrimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005329">
        <property type="protein sequence ID" value="KVH88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDR0"/>
    <dbReference type="STRING" id="59895.A0A103XDR0"/>
    <dbReference type="Gramene" id="KVH88858">
        <property type="protein sequence ID" value="KVH88858"/>
        <property type="gene ID" value="Ccrd_025205"/>
    </dbReference>
    <dbReference type="OMA" id="MPLWKYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="425"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="544" mass="57441" checksum="186AC0EAB3024D1F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE66</accession>
    <name>A0A103XE66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plant specific Rop nucleotide exchanger, PRONE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005312">
        <property type="protein sequence ID" value="KVH89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE66"/>
    <dbReference type="STRING" id="59895.A0A103XE66"/>
    <dbReference type="Gramene" id="KVH89098">
        <property type="protein sequence ID" value="KVH89098"/>
        <property type="gene ID" value="Ccrd_008918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000003">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2010">
        <property type="entry name" value="PRONE domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005512">
        <property type="entry name" value="PRONE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038937">
        <property type="entry name" value="RopGEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101:SF47">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03759">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51334">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRONE" evidence="3">
        <location>
            <begin position="56"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="42030" checksum="556645BBA39A18CF" modified="2016-04-13" version="1" fragment="single">DVNSCSSENHSPVCWPATGRSPYRPALSRFGLMKQNNKFEMDDKPKNHEPMDLGICKNEIFFGAELEMMKERFSKLLLGEDMSGSGKGVSTAVTVSNAITNLYASMFGQHQKLEPLHPEKKMMWKREMNCLLSVCDYIVEFIPASQNLQNGKAMEKNERKPSRDHDILESFEETEFWYVEQGSMSANSRSGSFRRIPQPQRKDEKWWLPVPCVPSEGLSEKARKNLRQKRDSANQIHKAAMAINSSILAEMEIPHTYIVSLPKLADRVEASMYTWRRKACASHSKTSWEMVKQHVAETERSDKNVVLAERADRCGTSNTRELLKGVGSILTDYASIKDHFKTVLSSCAVGSIASLWFLQRQDSETCSEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XED0</accession>
    <name>A0A103XED0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-ribulosamine 3-kinase, chloroplastic</fullName>
            <ecNumber evidence="7">2.7.1.172</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fructosamine 3-kinase-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01005309">
        <property type="protein sequence ID" value="KVH89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XED0"/>
    <dbReference type="STRING" id="59895.A0A103XED0"/>
    <dbReference type="Gramene" id="KVH89136">
        <property type="protein sequence ID" value="KVH89136"/>
        <property type="gene ID" value="Ccrd_008877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000264">
        <property type="entry name" value="Protein-ribulosamine 3-kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="259" mass="28538" checksum="E965C140693E2865" modified="2016-04-13" version="1">MVAQLGVISSTSSCHLFRSSHPFSIRLQKPMAMATVSTDPVREWILSEGKASQITGISPVGGGCINLASRYNTDAGSFFVKTNRSIGPEMFEGEALGLRAMYETKSIRVPQPFKVGALPTGGSYIIMEFIEFGSSRGDQSLLGRKLAEMHKATKSENGQRLVKNLGALFEDVTIEPCLLHGDLWSGNISSDKNGEPMDIMKQNSECHGVPVSEARSTMPILRRDVYLLYHYLNHYNLFGSGYRSSAMSIIDDYLRMLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEP4</accession>
    <name>A0A103XEP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">1,3-beta-glucan synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_008654</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005229">
        <property type="protein sequence ID" value="KVH89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEP4"/>
    <dbReference type="STRING" id="59895.A0A103XEP4"/>
    <dbReference type="Gramene" id="KVH89360">
        <property type="protein sequence ID" value="KVH89360"/>
        <property type="gene ID" value="Ccrd_008654"/>
    </dbReference>
    <dbReference type="OMA" id="YLLIWDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.270:FF:000002">
        <property type="entry name" value="callose synthase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="16">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="433" mass="50394" checksum="A9B3D82E3C659E53" modified="2016-04-13" version="1">MAYNRRGSDQHQPPPGRLLRTQTAGSLGMDSMMDSEVVPSSLAQIAPILRVANEIEPINPRVAYLCRFYAFEKAHKLDPTSSGRGVRQFKTLLLQRLEKEDKATFAGRTKSDAREMQSFYRHYFGKYIHAWQKADKADRTRLTKAYQTAAILFEVLKAVNLTESVEVADEILEAHTKVAEKTEMYVPYNILPLDPDSSNQAIMRYPEIQASVSALRNTRGLPWPKGYKKKEDGDILDWLQAMFGFQKDNVSNQREHLILLLANVHIRQFPKPDQQPKLDDCAVTEVMKKLFKNYKKWCKFLGRKITTQFLKPNLLTNKLPNIQQEVQQRKLLYMGLYLLIWGEAANLRFMPECLCYIYHHFKVSQRTIFSTLFLPNLTYHLWVYYLSISFININLPGSMAFDNIDFFAKNLTQTFAVLYMFDHFIFMFMCVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFF6</accession>
    <name>A0A103XFF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_008319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005174">
        <property type="protein sequence ID" value="KVH89687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFF6"/>
    <dbReference type="STRING" id="59895.A0A103XFF6"/>
    <dbReference type="Gramene" id="KVH89687">
        <property type="protein sequence ID" value="KVH89687"/>
        <property type="gene ID" value="Ccrd_008319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047117">
        <property type="entry name" value="PERK1-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="75"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="393" mass="44445" checksum="3636C3AE25BD705B" modified="2016-04-13" version="1">MAVREGGEKPSYNHLLKRCDVPMMMKKWSRSQRLISKYQFGAVPPATPPPAPSEPAEPRAIMLSFRDLQTATRGWRTDCFVAKGRTCEVFRGMLKNKQIVAIKRLRKDPAMVNRFLREYKSEKSFLHQLHHENIIELKGFCTELEELMLVLEFAPKGTLYDRLHDSNELLGWENRMRIALGAARAIDYIHHVVPGPVLHRDIKSTHIVIDEGYNAKLIDFGNAIYEPKETHYNHIVGTEPYTAPEYKRENRLTTKCDIYGFGVVLLELITGRKAAPEGDMRIMDWATVRLVATANWPTLVPGMIDERIRETVPPKDMVKMMKLATDCIRRDILDRPEASQVVARLLEISCLVRTAPSSSGGGISCLEHTIATNSIEGGNTVENSHGPVTTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFW5</accession>
    <name>A0A103XFW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_008064</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005123">
        <property type="protein sequence ID" value="KVH89943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFW5"/>
    <dbReference type="Gramene" id="KVH89943">
        <property type="protein sequence ID" value="KVH89943"/>
        <property type="gene ID" value="Ccrd_008064"/>
    </dbReference>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17362">
        <property type="entry name" value="MFS_GLUT10_12_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000118">
        <property type="entry name" value="D-xylose-proton symporter-like 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050820">
        <property type="entry name" value="MFS_Sugar_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48023">
        <property type="entry name" value="D-XYLOSE-PROTON SYMPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48023:SF4">
        <property type="entry name" value="D-XYLOSE-PROTON SYMPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH89943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="506" mass="54057" checksum="A8E597F4290F80E5" modified="2016-04-13" version="1">MASTTTSDPEHHHTFSSIGKAGKSSGEIEGMDVPLINGRRQSENYSVVAAILPFLFPAFGGLLYGYDIGATSSATINIKSLTSSGVSWYDLSSVQVGLITSGSLYGALIGSILAFNIADFLGRRRELMVSAASYIIGALVTTLAPGFAIMVIGRFIYGVGIGLAMHAAPMYIAETAACQIRGRLISLKEFFIVLGMVLGYVVGSLLVDVNAGWRYMYATAVPFAVVMGIGMWWLPASPRWILLRAIQGKGDMQDLREYAIYCLRRLRGEAINNSASQEVQEILVELSYISEENEATLGEMFQGKCLKALTVGGGLVLFQQITGQPSVLYYAASIFQTAGFSAASDATRASILLGLLKLVMTGVAVMVVDKLGRRPLLLGGVSGIVVALFLMGSFYTYLGNVPAVAVVALLLYVGCYQISFGPIGWLMISEIFPLRLRGRGLSIAVLINFGANALVAFAFSPLQDLLGAGAVFFIFGGIAVLALVFIFFIVPETKGLTLEEIEAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGE5</accession>
    <name>A0A103XGE5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IBH1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGE5"/>
    <dbReference type="STRING" id="59895.A0A103XGE5"/>
    <dbReference type="Gramene" id="KVH90209">
        <property type="protein sequence ID" value="KVH90209"/>
        <property type="gene ID" value="Ccrd_007782"/>
    </dbReference>
    <dbReference type="OMA" id="QNSSIEW"/>
    <dbReference type="OrthoDB" id="1647165at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11444">
        <property type="entry name" value="bHLH_AtIBH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044549">
        <property type="entry name" value="bHLH_AtIBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044660">
        <property type="entry name" value="IBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059002">
        <property type="entry name" value="IBH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124">
        <property type="entry name" value="TRANSCRIPTION FACTOR IBH1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26576">
        <property type="entry name" value="IBH1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IBH1-like N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="26195" checksum="5344721B3A0681AD" modified="2016-04-13" version="1">MASSTLIPNPVTNNTDRARDSSKRRKRKKIQRQSSGIGRDQNSQNLNNNNDQITPWKSEVQQQVYSSKLLQALRQVRQGSGSGTSSTKTPRRGRAVREAADRVLAVTAKGRTRWSRAILTNKLKLKFMKSNRRQRGVVATATGNRRLKKPRVSILRLKTKNLPAVQRKARVLGRLVPGCRKQPLPVVLEEATDYIAALEMQVKAMAALADLLSGGSSSSSSAGAGNLGQLSFSRSPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGJ1</accession>
    <name>A0A103XGJ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005106">
        <property type="protein sequence ID" value="KVH90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGJ1"/>
    <dbReference type="STRING" id="59895.A0A103XGJ1"/>
    <dbReference type="Gramene" id="KVH90331">
        <property type="protein sequence ID" value="KVH90331"/>
        <property type="gene ID" value="Ccrd_007654"/>
    </dbReference>
    <dbReference type="OMA" id="ELMEWLN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="750" mass="84195" checksum="C18FF276E7256A56" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH13</accession>
    <name>A0A103XH13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH13"/>
    <dbReference type="STRING" id="59895.A0A103XH13"/>
    <dbReference type="Gramene" id="KVH90554">
        <property type="protein sequence ID" value="KVH90554"/>
        <property type="gene ID" value="Ccrd_007410"/>
    </dbReference>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000040">
        <property type="entry name" value="Putative tatD related deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="37310" checksum="0456A669B515ED58" modified="2016-04-13" version="1">MATLRMIDIAVNFTDSMFKGVYNGKQCHLPDIAAVLSRAWGAGVDRIIVTGGSLEESREALAIAETDDTWEWYSTEGSMFVAARLFCTVGVHPTRCNEFDESGDPEKHFQALLSLAKEGVEKGKVVAVGECGLDYDRTHFCSPEIQRKYFERQFELAHLLKLPMFLHMRAAAGDFCDILEQNKQRFYGGVAHSFTGTPEDRDKLLAFSNLFIGINGCSLKTSENLDALKGIPVDRMMIETDSPYCEIKNTHAGKNFIKSSWASKKKEKYDQDCLVKGRNEPCLVRQVLEVVGGCKGVADLNQLSRTLYYNTCRVFFPHDLDSAADGLLSGVQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHR5</accession>
    <name>A0A103XHR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Gnk2-homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_006954</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell junction</location>
            <location evidence="12">Plasmodesma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHR5"/>
    <dbReference type="STRING" id="59895.A0A103XHR5"/>
    <dbReference type="Gramene" id="KVH91006">
        <property type="protein sequence ID" value="KVH91006"/>
        <property type="gene ID" value="Ccrd_006954"/>
    </dbReference>
    <dbReference type="OMA" id="SECIAQA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046739">
        <property type="term" value="P:transport of virus in multicellular host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000001">
        <property type="entry name" value="cysteine-rich repeat secretory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000008">
        <property type="entry name" value="cysteine-rich repeat secretory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051378">
        <property type="entry name" value="Cell2Cell_Antifungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080">
        <property type="entry name" value="ANTIFUNGAL PROTEIN GINKBILOBIN-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080:SF53">
        <property type="entry name" value="GNK2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="16">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="16">
        <location>
            <begin position="180"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH91006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="37705" checksum="A4AD44B30F2A770E" modified="2016-04-13" version="1" fragment="single">NHPLYHYSISQIYLEIKNHGFDLIHTEKKRKEKKRRRKTTIISQMCSMKPLLLISLFILLSVDQAISAPDNTNLVYKGCAKQPLSDPNGVYSSALSAIFGTLIQQSSKAKFFKTTSGNGQASVSGLFQCRGDLSNVDCYTCVSRLPILMDKLCGKTVAARIQLLGCYMLYEVSGFAQISGMELLYKTCGSSNAGGSGFQERRDSAFSSLESVVGSASGGFYTTTYESVYVLGQCQGDLGTSDCGNCVKSAVQRAQVECGSSISGQIYLHRCFISYNYYPNGTPKPKNPSASASSSSSSSYSSPSSSSSSSSSSSGSNTGKTVAIILGGAAGVGFLIVFLLMARNAMKKHDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIB9</accession>
    <name>A0A103XIB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005056">
        <property type="protein sequence ID" value="KVH91280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIB9"/>
    <dbReference type="STRING" id="59895.A0A103XIB9"/>
    <dbReference type="Gramene" id="KVH91280">
        <property type="protein sequence ID" value="KVH91280"/>
        <property type="gene ID" value="Ccrd_006701"/>
    </dbReference>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047918">
        <property type="term" value="F:GDP-mannose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05273">
        <property type="entry name" value="GME-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033890">
        <property type="entry name" value="GDP-Man_epi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="362" mass="41079" checksum="F7E6B21FEF2B60A1" modified="2016-04-13" version="1">MGTGETKYGSFTYENLEREPYWPSDKLRISITGAGGFIASHIARRLKTEGHYIIASDWKKNEHMPEDMFCHEFHLVDLRVMDNCLKVTENVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMLEASRINGVKRFFYASSACIYPEFKQLETNVSLKEADAWPAEPQDAYGLEKLATEELCRHYTKDFGIECRIGRFHNIYGPFGTWKALTSTDKFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEIVLGFEDKKLPIHHIPGPEGVRGRNSDNTLIKEKLGWAPTMKLKDGLRITYFWIKEQIEKERGAGFDLSVYGSSKVVGTQAPVQLGSLRAADGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIS3</accession>
    <name>A0A103XIS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP1/OBG, conserved site-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004964">
        <property type="protein sequence ID" value="KVH91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIS3"/>
    <dbReference type="STRING" id="59895.A0A103XIS3"/>
    <dbReference type="Gramene" id="KVH91459">
        <property type="protein sequence ID" value="KVH91459"/>
        <property type="gene ID" value="Ccrd_006518"/>
    </dbReference>
    <dbReference type="OMA" id="HVQRCRV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000515">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="entry name" value="GTP-binding protein OBG, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008954">
        <property type="entry name" value="PRK12296.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008955">
        <property type="entry name" value="PRK12297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008956">
        <property type="entry name" value="PRK12299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF44">
        <property type="entry name" value="GTP-BINDING PROTEIN OBGC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="Obg GTP-binding protein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="110"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="273"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="468"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62428" checksum="66ACBC0BAE216ADA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJY0</accession>
    <name>A0A103XJY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004895">
        <property type="protein sequence ID" value="KVH91979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJY0"/>
    <dbReference type="STRING" id="59895.A0A103XJY0"/>
    <dbReference type="Gramene" id="KVH91979">
        <property type="protein sequence ID" value="KVH91979"/>
        <property type="gene ID" value="Ccrd_006001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="82" mass="8626" checksum="0DF39EBAE857FEB2" modified="2016-04-13" version="1">MDGGVTAEQGTVTCASWIRRPEDAHLVALGKSKHGDLPASFQIFSFDRLTTSLSSSPSVSPSPSSSLCTHVFFYVYCLGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK16</accession>
    <name>A0A103XK16_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_005779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004836">
        <property type="protein sequence ID" value="KVH92195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK16"/>
    <dbReference type="STRING" id="59895.A0A103XK16"/>
    <dbReference type="Gramene" id="KVH92195">
        <property type="protein sequence ID" value="KVH92195"/>
        <property type="gene ID" value="Ccrd_005779"/>
    </dbReference>
    <dbReference type="OMA" id="YPNPHRP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000352">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000061">
        <property type="entry name" value="Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF99">
        <property type="entry name" value="INACTIVE ATP-DEPENDENT ZINC METALLOPROTEASE FTSHI 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="330"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH92195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="839" mass="94484" checksum="2BB41F6A0FE0147C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLZ1</accession>
    <name>A0A103XLZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lateral Root Primordium type 1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHI protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004791">
        <property type="protein sequence ID" value="KVH93227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLZ1"/>
    <dbReference type="STRING" id="59895.A0A103XLZ1"/>
    <dbReference type="Gramene" id="KVH93227">
        <property type="protein sequence ID" value="KVH93227"/>
        <property type="gene ID" value="Ccrd_004749"/>
    </dbReference>
    <dbReference type="OMA" id="MITSHFT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007818">
        <property type="entry name" value="SHI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006511">
        <property type="entry name" value="SHI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006510">
        <property type="entry name" value="Znf_LRP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01624">
        <property type="entry name" value="LRP1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01623">
        <property type="entry name" value="put_zinc_LRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31604">
        <property type="entry name" value="PROTEIN LATERAL ROOT PRIMORDIUM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31604:SF54">
        <property type="entry name" value="PROTEIN SHI RELATED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05142">
        <property type="entry name" value="DUF702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20669" checksum="8F27875716938E70" modified="2016-04-13" version="1">MRCQECGNKAKRDCLYYRCRSCCKGRGFECETHVKSTWAPASSTKHQVSADYSTHISHHHQEEEEQHGQQLHLPSSSSDMCFPTKMVGESTFTCVRVTSTSEENAIVDQYAYETSINIGGHVFKGILYDQGPSHQMMNFQDRNADGGDQQNSTINIQSDSQPLDKPRPSSPPDFSFDIYPHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNV3</accession>
    <name>A0A103XNV3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LOW PSII ACCUMULATION 1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNV3"/>
    <dbReference type="STRING" id="59895.A0A103XNV3"/>
    <dbReference type="Gramene" id="KVH94276">
        <property type="protein sequence ID" value="KVH94276"/>
        <property type="gene ID" value="Ccrd_003679"/>
    </dbReference>
    <dbReference type="OMA" id="KVPWRQM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021883">
        <property type="entry name" value="LPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35498:SF1">
        <property type="entry name" value="LOW PSII ACCUMULATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35498">
        <property type="entry name" value="PROTEIN LOW PSII ACCUMULATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11998">
        <property type="entry name" value="DUF3493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31051" checksum="2A99E24530AB50F8" modified="2016-04-13" version="1">MSTVAQLAVVTGTCCNFHRTSKCLGFSFHNLTSVVATTRIRTATIRNRAKAPLSVTCSAAKPSSSTEISSTARIRSEVLTPFRSVRMFFYIAFVAQASLGGLIATTQLIGALANPSRADAVTDITKGLGIDIGAASLFAFLYYRENKIKNAQMARLSREENLSNLKLRVDEKKIITVSEFRGLARLVILAGPSSFITEAFRLSEMFTEQLIERGVLVVPFSTDGNAPTFEFDETEDMEELTNKRRRLWQLVPVLTPEWSEWLDDQKKLANVSPESPVTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ96</accession>
    <name>A0A103XQ96_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of 2 alpha and 2 beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ96"/>
    <dbReference type="STRING" id="59895.A0A103XQ96"/>
    <dbReference type="Gramene" id="KVH94784">
        <property type="protein sequence ID" value="KVH94784"/>
        <property type="gene ID" value="Ccrd_003152"/>
    </dbReference>
    <dbReference type="OMA" id="FCSTYRD"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="9">
        <location>
            <begin position="90"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="47317" checksum="5155D8DC1347A6A4" modified="2016-04-13" version="1">MAFSGAKIIQPLPLHTTIRSPNNPLLFDPFTSSPFLGSTRTLRLSQSISASQRRCASHIVAVSDVFKEKKLKSNTNLLLTKEEGLQVYEDMILGRAFEDMCAQMYYRGKMFGFVHLYNGQEAVSSGFIKLLKKEDSVVSTYRDHVHALSKGVPARAVMSELFGKKTGCCRGQGGSMHMFSAEHNVLGGFAFIGEGIPVATGAAFASKYRREVLKEADCDHVTLAFFGDGTCNNGQFFECLNMAALWKLPIIFVVENNLWAIGMSHLRSTSDPEIWKKGPAFGMPGVHVDGMDVLKVREVAKEAIGRARRGEGPTLVECETYRFRGHSLADPDELRDPAEKARYAARDPITALKKYLIESKLANEAELLAIEKKIEEVVEDAVEFADESPAPSRSQLLENVFADPRGFGIGPDGSYRCEDPKFTEGTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRE6</accession>
    <name>A0A103XRE6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004385">
        <property type="protein sequence ID" value="KVH95506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRE6"/>
    <dbReference type="STRING" id="59895.A0A103XRE6"/>
    <dbReference type="Gramene" id="KVH95506">
        <property type="protein sequence ID" value="KVH95506"/>
        <property type="gene ID" value="Ccrd_002412"/>
    </dbReference>
    <dbReference type="OMA" id="INIQDIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="589"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="661" mass="72789" checksum="E9814BD9DEFB2496" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRT0</accession>
    <name>A0A103XRT0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004380">
        <property type="protein sequence ID" value="KVH95654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRT0"/>
    <dbReference type="STRING" id="59895.A0A103XRT0"/>
    <dbReference type="Gramene" id="KVH95654">
        <property type="protein sequence ID" value="KVH95654"/>
        <property type="gene ID" value="Ccrd_002265"/>
    </dbReference>
    <dbReference type="OMA" id="CCNLDDG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF44">
        <property type="entry name" value="OS04G0481200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119041" evidence="5">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="71"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="45903" checksum="DA5BE06F76F1DDFC" modified="2016-04-13" version="1">MGLKFSSSLLLFILAAVIHHHHPTTALPLSTNSRWIVDNGNGGERVKLSCVNWVSHLDAVVAEGLSKQPVDAISNKISAMGFNCVRLTYPLFLFTNDSFASVTVRQSLRKLGLIESIAGFQSNNPSIIDLPLLQAFQLEMELLDNDSFVSSLDRNNIMMILDNQISTPGWCCSDFDGNGFFGDPYFNPDVWLKGLTKVATMFNGSTNVVGMSLRNELRGPRQNVSVWYRYMQKGAEAVHAANPNVLVIVSGLSYDKDLSFLHTQPLTLTFSQKLVYEIHWYGFSNSEDWETGNPNDVCGRVVENITAKSGFLLDQGYPLFVSEWGVDQRGTNENDNRFLNCFLAWAAEYDLDWALWTLAGSYYFRQGVVGMEEFYGVLNWDWCKPRNSSFLEKISPLQSPFQGNKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSZ7</accession>
    <name>A0A103XSZ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004332">
        <property type="protein sequence ID" value="KVH96332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSZ7"/>
    <dbReference type="Gramene" id="KVH96332">
        <property type="protein sequence ID" value="KVH96332"/>
        <property type="gene ID" value="Ccrd_001581"/>
    </dbReference>
    <dbReference type="OMA" id="FYYIAFI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="131" mass="15457" checksum="3C6286C497365061" modified="2016-04-13" version="1">MVLLFNYLKSAWSILLHHSFFNHHLHWVPHELIDVVPHRTCRLDPGSFEQVECTVCLSAIGEDEQIKELRCGHLFHQLCLDQWLGFGNMTCPLCRDCLMSARVVLDIRNELLVFDYFSTRDSQDEGLWWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTC1</accession>
    <name>A0A103XTC1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004290">
        <property type="protein sequence ID" value="KVH96480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTC1"/>
    <dbReference type="STRING" id="59895.A0A103XTC1"/>
    <dbReference type="Gramene" id="KVH96480">
        <property type="protein sequence ID" value="KVH96480"/>
        <property type="gene ID" value="Ccrd_001435"/>
    </dbReference>
    <dbReference type="OMA" id="CKVPAAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="144"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="31130" checksum="AB3693A4FCEE8481" modified="2016-04-13" version="1">MGVTTYDMEVETAVPAAKLYQSFILDGDTLVPKVVPQAMKSVEILEGDGGAGTIKLITFGEGKSLTYSLYNSQSSILQKDIRSQFKSVKHKIDEVDKDNMSYSYSIIEGDVLVDPLESISYHIKVVPTDQGGCILKHKSIYTCKVPAAKLYQSFILDGDTLFPKVAPQAMKSVEILEGDGGAGTIKLITFGSQFKSVKHKIDEVDKDNLSYSYSIIEGDILVDPLESISYHIKLVPTDQGGCILKHQSIYTCKGDVKIAEEDIKKGKEKAQGLFKAIEAYLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTX3</accession>
    <name>A0A103XTX3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="5">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_001132</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004192">
        <property type="protein sequence ID" value="KVH96778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XTX3"/>
    <dbReference type="Gramene" id="KVH96778">
        <property type="protein sequence ID" value="KVH96778"/>
        <property type="gene ID" value="Ccrd_001132"/>
    </dbReference>
    <dbReference type="OMA" id="PITTGQF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="18">
        <location>
            <begin position="357"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH96778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="699" mass="78463" checksum="675F9C0280B6C526" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUK9</accession>
    <name>A0A103XUK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003849">
        <property type="protein sequence ID" value="KVH97205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH97205">
        <property type="protein sequence ID" value="KVH97205"/>
        <property type="gene ID" value="Ccrd_000691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11073">
        <property type="entry name" value="CYP76-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000007">
        <property type="entry name" value="Cytochrome P450 76C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950:SF48">
        <property type="entry name" value="CYTOCHROME P450 FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY C, POLYPEPTIDE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="749"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="784"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="1401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1912" mass="216674" checksum="CCE8857839162BA9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVC2</accession>
    <name>A0A103XVC2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVC2"/>
    <dbReference type="STRING" id="59895.A0A103XVC2"/>
    <dbReference type="Gramene" id="KVH97486">
        <property type="protein sequence ID" value="KVH97486"/>
        <property type="gene ID" value="Ccrd_000433"/>
    </dbReference>
    <dbReference type="OMA" id="ERYGRMI"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF254">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="51494" checksum="8D1065E76BDCC852" modified="2016-04-13" version="1">MGIMGKSFSVKVVDKVVVSAEEPWTDHWLSFTNLDLLVPPFNVSSFFCYNKPSHGSFPTMLNTLKASLSQALALYPPVSGDIAWNGAAGKNQIHCNNQGVDFILAFADVELKELNFYNPDDSIEGKLMPEKQRGVCAIQVTELKCGGMVIAIKFDHRIVDGYSANMFISSWADMARSEAPSMIPSFTRSHMNPRSPPIYSSSIDDVFAVYSPQSHPDDDQNHDHGDNIAVNRIYYIKGEQLKRLQSLASESGRRRSKLVAFTSYLWKNLALSMEDAGNHNEVCNVAVAVDGRRRLSEGDGEQKEKLMDLHFGNVLSIPYGTKKSQELNEMSLSNVATDVHEFLQTATGKDHFLDLIDWVEEQGPQPLIAKAFASKDMSVMVSSGQRFHTMDEMDFGWGKLLFGSCHVPSERKDCFVMTMGSPTNNEDWVVYLHLPLKHMKFMEAHASDVFKPLDADYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW76</accession>
    <name>A0A103XW76_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW76"/>
    <dbReference type="STRING" id="59895.A0A103XW76"/>
    <dbReference type="Gramene" id="KVH98028">
        <property type="protein sequence ID" value="KVH98028"/>
        <property type="gene ID" value="Ccrd_023772"/>
    </dbReference>
    <dbReference type="OMA" id="RDACMMV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000003">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="37233" checksum="C93E4E7BF70C2786" modified="2016-04-13" version="1">MAGASIAGVQDHLKLAREYAVEGLYDTSVIFFDGAIAQINKHLNSLDDPLVRSKWMNVKKALSEETEVVKQLDSEKRSFKDTSVGRRPTSPPISTNKSSFVFEPLDEYPTSSGAPMDDPDVWRPPSRDTSNRRSARGGVGATRKSPQDGAWARGSTTRGGATARGGKTGASGRANSGVRASNGDAEEATTKRGQYEGPDHDLAAMLERDVLENTPGVRFEDVAGLTEAKRLLEEAVGIRRPWKGVLMFGPPGTGKTLLAKAVATECGTTFFNVSSATLASKWRGESERMVRCLFDLARAYAPSTIFIDEIDSLCTSRGASGEHESSRRVKSELLVQVDGVNNTGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW96</accession>
    <name>A0A103XW96_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_023727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003811">
        <property type="protein sequence ID" value="KVH98058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW96"/>
    <dbReference type="STRING" id="59895.A0A103XW96"/>
    <dbReference type="Gramene" id="KVH98058">
        <property type="protein sequence ID" value="KVH98058"/>
        <property type="gene ID" value="Ccrd_023727"/>
    </dbReference>
    <dbReference type="OMA" id="CGLPINK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051502">
        <property type="entry name" value="RLP_Defense_Trigger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062:SF21">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119155" evidence="11">
        <location>
            <begin position="30"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH98058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="836" mass="94102" checksum="99BC48B60A78CFAA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXU7</accession>
    <name>A0A103XXU7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003643">
        <property type="protein sequence ID" value="KVH98867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXU7"/>
    <dbReference type="Gramene" id="KVH98867">
        <property type="protein sequence ID" value="KVH98867"/>
        <property type="gene ID" value="Ccrd_022907"/>
    </dbReference>
    <dbReference type="OMA" id="GAWENAK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="227" mass="23975" checksum="1D8DBB0219C91382" modified="2016-04-13" version="1">MQQMEANVIVNCVHPGIVRTGQTRDHNGFITVVLALQQGFAIGSAALVSLALFGAFVSRAGIETVDVLTPKVFIGLLIGAMLPYWFSAMTMKSVGSVALKMVEEVWRQFNTIPGLMEGTTKPDYATCVKISIDVSLKEMIPPGALVMITTLVAGTLFGVELLAGVLASSLVSGVQVHVLYAIFLVTSIIVFARALGPKGSEAHKAAVIGDTVGDPLKDTSGPSLIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0G4</accession>
    <name>A0A103Y0G4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0G4"/>
    <dbReference type="STRING" id="59895.A0A103Y0G4"/>
    <dbReference type="Gramene" id="KVI00244">
        <property type="protein sequence ID" value="KVI00244"/>
        <property type="gene ID" value="Ccrd_021501"/>
    </dbReference>
    <dbReference type="OMA" id="MLCYSCP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000222">
        <property type="entry name" value="casein kinase 1-like protein HD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055900">
        <property type="entry name" value="DUF7477"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24289">
        <property type="entry name" value="DUF7477"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="133"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="792" mass="88952" checksum="2EAC7A8181FBDEEA" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0T9</accession>
    <name>A0A103Y0T9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0T9"/>
    <dbReference type="Gramene" id="KVI00427">
        <property type="protein sequence ID" value="KVI00427"/>
        <property type="gene ID" value="Ccrd_021402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36078">
        <property type="entry name" value="BNACNNG21220D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36078:SF2">
        <property type="entry name" value="OS09G0473966 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17261" checksum="D11E83E69F0B97EB" modified="2016-04-13" version="1">MEGSKKGTSKDTMSNLEKLQADFAVYLRHKYFSGKDIEGEEIFEEIAKIGGMTIKGSRFPPTSSYEDPVAYRNGFTASCVEVEKNLLADLVDEENRIPRLEYPVKPARNQVEPLGVQDTSDDSSDSLQEISADAWNEVQSAIKQAKSGVGPSQKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1N2</accession>
    <name>A0A103Y1N2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication protein A 70 kDa DNA-binding subunit B/D first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003196">
        <property type="protein sequence ID" value="KVI00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1N2"/>
    <dbReference type="Gramene" id="KVI00874">
        <property type="protein sequence ID" value="KVI00874"/>
        <property type="gene ID" value="Ccrd_020862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04480">
        <property type="entry name" value="RPA1_DBD_A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="310" mass="35349" checksum="C6C91934B57F33C6" modified="2016-04-13" version="1">MSTPSKDPLLQVETTCGSLLYELQGSLMTAMVRKNLVYKFNHLLKEGNVYVLKNFKVVENSGAFKVIDSNLKIIFTLLTKVEKIDTHVPSIPMHGFQLASEKIVNDRLNDDNILTDIIGCLTVVGDVETVRGGFRKRDLEIISELFANVCPRLQLGVSSGKVKRTVEEEMFENRMNHSTTVAGRVEQQTKRNAKRQLFHHFMYSDQTIFDSTLTSSYLTFKLHLSVRDDTGVVNYVVLHKLAERMRYLYRLKVFDPDYVVEKEYKPVDSTTETILIENLDVIGGTQPCNNATPTTTRKRKFIVNDDEAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2P4</accession>
    <name>A0A103Y2P4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD-binding, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003106">
        <property type="protein sequence ID" value="KVI01405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2P4"/>
    <dbReference type="STRING" id="59895.A0A103Y2P4"/>
    <dbReference type="Gramene" id="KVI01405">
        <property type="protein sequence ID" value="KVI01405"/>
        <property type="gene ID" value="Ccrd_020325"/>
    </dbReference>
    <dbReference type="OMA" id="HRMYSIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000023">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000146">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF129">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="104"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="307"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="661" mass="73655" checksum="BDBBBAD8E73C7696" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y321</accession>
    <name>A0A103Y321_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002971">
        <property type="protein sequence ID" value="KVI01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y321"/>
    <dbReference type="STRING" id="59895.A0A103Y321"/>
    <dbReference type="Gramene" id="KVI01619">
        <property type="protein sequence ID" value="KVI01619"/>
        <property type="gene ID" value="Ccrd_020106"/>
    </dbReference>
    <dbReference type="OMA" id="HAAYHQI"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF146">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT C-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="241" mass="27297" checksum="22CDE4F7A0037A4A" modified="2016-04-13" version="1">MDQQEHGQGSSGQMPYGVAPYPPNQIQTPQSVGLPSPPTQLAQQQLAYQHIHQQQQQQLHQQLQNFWANQYQEIEQTTDFKNHSLPLARIKKIMKADEDVRMISAEAPVIFARACEMFILELTLRSWNHTEENKRRTLQKNDIAAAITRTDIFDFLVDIVPREDLKDEVLASTIPRGGPLPVGPPTEGLPYYYMPPPQVGGSGMYMGKPVDPQALYGQQPNPYMAQPLWPQQQEQEPQGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3Y3</accession>
    <name>A0A103Y3Y3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3Y3"/>
    <dbReference type="STRING" id="59895.A0A103Y3Y3"/>
    <dbReference type="Gramene" id="KVI02091">
        <property type="protein sequence ID" value="KVI02091"/>
        <property type="gene ID" value="Ccrd_019640"/>
    </dbReference>
    <dbReference type="OMA" id="EINPNHY"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000005">
        <property type="entry name" value="heat shock protein 90-5, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000024">
        <property type="entry name" value="heat shock protein 90-5, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="794" mass="90260" checksum="9214554D14BF768C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y425</accession>
    <name>A0A103Y425_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002662">
        <property type="protein sequence ID" value="KVI02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y425"/>
    <dbReference type="STRING" id="59895.A0A103Y425"/>
    <dbReference type="Gramene" id="KVI02141">
        <property type="protein sequence ID" value="KVI02141"/>
        <property type="gene ID" value="Ccrd_019571"/>
    </dbReference>
    <dbReference type="OMA" id="ARTFVKF"/>
    <dbReference type="OrthoDB" id="974159at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="369" mass="42076" checksum="6449025495DD9131" modified="2016-04-13" version="1">MILSKTLRSHQIRTLSNLSHTSLSHLPLNPKQHHTEPHLISSTIPTSIFSRNISLSSQFRHEFATQNPNHNSKKPLEAFFTEAIGLSKPDTEDGHDEKKELKKSLQKLEEELRRSKKDPSKETTTSSNSFSKKPLETLFTEAIGLSKIGEEIDINEIENDGRESQKGLKTLSSFFLSNDQRGKLIKESKKLEESMDFKQLSSDMAEFAAYLHSKGYLKTANFLQNNKFDVSCFENSFGRDYLKFAAENFARDHREIHKWLPDKDLKTVAQFGCPSLGRKNIFSAKSMRLFYGIQEETVCNKCVLKESCKFVNQSVWKKGAKNMDLIAVMRVVTLYGLEAIPTQLEVPDDVKNAVNRLLKEVVRLSKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5F8</accession>
    <name>A0A103Y5F8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Auxilin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5F8"/>
    <dbReference type="STRING" id="59895.A0A103Y5F8"/>
    <dbReference type="Gramene" id="KVI02854">
        <property type="protein sequence ID" value="KVI02854"/>
        <property type="gene ID" value="Ccrd_018851"/>
    </dbReference>
    <dbReference type="OMA" id="FQGFHAS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF87">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132548" checksum="957AB1B8005C9AF8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y663</accession>
    <name>A0A103Y663_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_018471</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a key role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002402">
        <property type="protein sequence ID" value="KVI03234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y663"/>
    <dbReference type="STRING" id="59895.A0A103Y663"/>
    <dbReference type="Gramene" id="KVI03234">
        <property type="protein sequence ID" value="KVI03234"/>
        <property type="gene ID" value="Ccrd_018471"/>
    </dbReference>
    <dbReference type="OMA" id="PGTCLRE"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000281">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase B2,2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI03234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="34533" checksum="E20E90AD1EA2FD99" modified="2016-04-13" version="1">MEDKYEKLEKVGEGTYGKVYKAKDIQTGQLVALKKTRLEMDEEGIPPTALREISLLQMLSNSIYIVRLITVEHIHHNGKPLLYLVFEYLDTDLKKFIDSHRKGPNPSPLPPSQIQSFLFQLCKGVAHCHGHGVLHRDLKPQNLLVDKEKGILKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMARRQALFPGDSEFQQLLHIFRLLGTPTEEQWPGVSSLRDWHVYPRWEAQNLARAVPSLGPDGVDLLSKMLQYDPADRISAKAAMDHPYFDTLDKSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8N4</accession>
    <name>A0A103Y8N4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002012">
        <property type="protein sequence ID" value="KVI04534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8N4"/>
    <dbReference type="STRING" id="59895.A0A103Y8N4"/>
    <dbReference type="Gramene" id="KVI04534">
        <property type="protein sequence ID" value="KVI04534"/>
        <property type="gene ID" value="Ccrd_017146"/>
    </dbReference>
    <dbReference type="OMA" id="IHIVWLM"/>
    <dbReference type="OrthoDB" id="1916993at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376:SF4">
        <property type="entry name" value="KAZAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, KAZAL-TYPE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119489" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13076" checksum="FC04A00E903A4DE3" modified="2016-04-13" version="1">MSAKPPSPILLLLLLTIAVAVTALPTSVRSNPDLIVLPSSTSLCPHSVNPGSCPIKCFRPAPVCGVDNVTYWCGCSEAICAGVPVAKLGFCDFENGGSGPVSGQALLLVHIVWLILLGFFVLFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8T0</accession>
    <name>A0A103Y8T0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001969">
        <property type="protein sequence ID" value="KVI04600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8T0"/>
    <dbReference type="Gramene" id="KVI04600">
        <property type="protein sequence ID" value="KVI04600"/>
        <property type="gene ID" value="Ccrd_017076"/>
    </dbReference>
    <dbReference type="OMA" id="LHEDPRM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="141"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI04600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="26088" checksum="22F377548E79A731" modified="2016-04-13" version="1">MNDSYWKYAAAEGRQQQQQQPPLQQLIGKRPRPDYDGPGGRDLPNYFAREDERGTQLVVKDSDTIGASYDRYLRGTQFPSYGGIEPARPMSTGLGGRLHEDPRMMGMGLGGLDSTIAATKGRDAGMVGGRPEISLPPDASNTLFVEGLPSNCSRREVARILFQLSTLLNFYFSSGDPLVLCFVDFESPAEAATAKDALQGYKFDEHDRDSVSLRLQFARYPGARSGGGARSGGGNRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9B3</accession>
    <name>A0A103Y9B3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syntaxin/epimorphin, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001902">
        <property type="protein sequence ID" value="KVI04883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9B3"/>
    <dbReference type="STRING" id="59895.A0A103Y9B3"/>
    <dbReference type="Gramene" id="KVI04883">
        <property type="protein sequence ID" value="KVI04883"/>
        <property type="gene ID" value="Ccrd_016797"/>
    </dbReference>
    <dbReference type="OMA" id="NTPSQQM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009504">
        <property type="term" value="C:cell plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF228">
        <property type="entry name" value="SYNTAXIN-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="39251" checksum="3E6A5618E2F8209C" modified="2016-04-13" version="1">MVSAGASTYRDRTSEFRSLSDTLKKFGRISAANPDRTYQHNDPSTSSKLPLTPSSYRSEFNKKASRIGLGIHETSKKIARLANLGKKSSIFDDPLKEIQELTALIKNDITALNVAVSDLQTLQNMEIADGDYSEDRVVHSTAVCDDLKNKLMGATKKFQDVLTARSEVCIHGNIKAHENRRQIFSTNISRGNPLRQQTENVMEPPPWSSPSRSSANQPSESSGSGVQVGNQLRRRLAADTTPSQHMEASMLQQQQVVPQQENYSQNRAVALQSVESTITELSGIFTNLATMVAHQGELAIRIDDNMEETMSNVEGARGALLKHLNRISSNRWLLIKIFAILIFFLIIFLFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA52</accession>
    <name>A0A103YA52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001878">
        <property type="protein sequence ID" value="KVI05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA52"/>
    <dbReference type="Gramene" id="KVI05329">
        <property type="protein sequence ID" value="KVI05329"/>
        <property type="gene ID" value="Ccrd_016331"/>
    </dbReference>
    <dbReference type="OMA" id="NQERCGQ"/>
    <dbReference type="OrthoDB" id="1908613at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044787">
        <property type="entry name" value="HHO5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058673">
        <property type="entry name" value="HHO5-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB-RELATED FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26575">
        <property type="entry name" value="HHO5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="42400" checksum="279677D70B52C8A4" modified="2016-04-13" version="1">MVMNNDPSDVRDKMQKYQEYIGALEEERRKIRVFERELPLCLELVSKAIERCRQEMSRDCFNVQSDQYSEQTSNEGPVLEEFIPIKRNLFTNEDEGEGQQQQEQQLSHKSKNICSQDKSSPFSLKPDWLTSAQLSIQSPDPPIEEDLLSKKLFATEVNRNGYGDYHPFKKKKSSCAALTTGVEKSLTCAAMVPTAAVSSSVDTDGGGGDGGGGGSKGEDKGKSNIKERRCWSTELHRRFLHALQQLGGAHVATPKQIRELMKVDGLTNDEIKSHLQKYRLHTRRLNPTIHNNDPHTAQLVVVGRIWMPPLEYTRKAASFPPSGNTNNAKVVYAPIASLPPSITASRYKTRQCKQQSNYEEKGSQSHSNSPSTTTISPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAU5</accession>
    <name>A0A103YAU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory factor, effector, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAU5"/>
    <dbReference type="Gramene" id="KVI05667">
        <property type="protein sequence ID" value="KVI05667"/>
        <property type="gene ID" value="Ccrd_016002"/>
    </dbReference>
    <dbReference type="OMA" id="WRSHCIA"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF36">
        <property type="entry name" value="SOUL HEME-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="199" mass="21854" checksum="3506126505FE1B0E" modified="2016-04-13" version="1">MVLLSCYRHVNATESPPYTVVLSAPDLEIRLYRDSSWISAAVAGGTSFNKSTHDGFHRLYQYVHGGNEYNTRFKITTPTVTTVTAAASNGSSDYLVSMYVASISSPPMASPQLNLHISNWKNHCVAVRRFSGFAGDDNIYKERSLLSFSLAKSLILNGKNVSISDDKSSYSIAQYNASSHLSGRVNEAWINVIPCPVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAZ9</accession>
    <name>A0A103YAZ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAZ9"/>
    <dbReference type="STRING" id="59895.A0A103YAZ9"/>
    <dbReference type="Gramene" id="KVI05770">
        <property type="protein sequence ID" value="KVI05770"/>
        <property type="gene ID" value="Ccrd_015966"/>
    </dbReference>
    <dbReference type="OMA" id="AWKTGNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="557" mass="58601" checksum="A0BB91B49366B1E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB26</accession>
    <name>A0A103YB26_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB26"/>
    <dbReference type="STRING" id="59895.A0A103YB26"/>
    <dbReference type="Gramene" id="KVI05816">
        <property type="protein sequence ID" value="KVI05816"/>
        <property type="gene ID" value="Ccrd_015848"/>
    </dbReference>
    <dbReference type="OMA" id="SMWVICY"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048868">
        <property type="term" value="P:pollen tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000007">
        <property type="entry name" value="probable xyloglucan glycosyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044">
        <property type="entry name" value="GLUCOMANNAN 4-BETA-MANNOSYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044:SF80">
        <property type="entry name" value="XYLOGLUCAN GLYCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="11">
        <location>
            <begin position="322"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="690" mass="79170" checksum="5B2F7D0DA676D353" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCU4</accession>
    <name>A0A103YCU4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001668">
        <property type="protein sequence ID" value="KVI06749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCU4"/>
    <dbReference type="Gramene" id="KVI06749">
        <property type="protein sequence ID" value="KVI06749"/>
        <property type="gene ID" value="Ccrd_014897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="71" mass="8187" checksum="1451DF60E7573885" modified="2016-04-13" version="1">MLSAAPPENSGLQPLFQIGRDCFHMNSGLQPLFHHTACSFFQPSNLRCKKYKVQSINMMMHQEALGHRIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD86</accession>
    <name>A0A103YD86_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001539">
        <property type="protein sequence ID" value="KVI06950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD86"/>
    <dbReference type="STRING" id="59895.A0A103YD86"/>
    <dbReference type="Gramene" id="KVI06950">
        <property type="protein sequence ID" value="KVI06950"/>
        <property type="gene ID" value="Ccrd_014699"/>
    </dbReference>
    <dbReference type="OMA" id="HFSNICE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000036">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="110"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="45831" checksum="3697854E7CD70F78" modified="2016-04-13" version="1" fragment="single">VHKQLLIPRYKQRSRLLLHTHIILSDSKILCSISSSTLLPFSLQFATTFFSFFYLHNLRNNLKLVIFIKISTTLCFMAIEASSFKYEEEFIVNSKGLELFTCRWLPVDSEPKALIFLNHGYGMECSVSMRGVALRLVKAGFAVYGIDNQGHGKSSGIQGFIPNFDDLVTDCSEFFTSICEKKENKRKMRILLGESMGGGMVLLLHRKNPEYWDGGVLVAPMCKIAEDMKPPQLVINVLMQLAKVIPTWKIVPGKDIVDLAFRDPKIREEVRNNPLCYKGRLRLQTASQLLNVSLDLEKRLQEVTFPFFVAHGEADRVTDPTVSKLLYETASSFDKKFQLYPGMWHSLTYGEFEENIDMVFTDVISWIDERISSGNSRLEREQKRANDEFDMDGSSNAKMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEB2</accession>
    <name>A0A103YEB2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEB2"/>
    <dbReference type="STRING" id="59895.A0A103YEB2"/>
    <dbReference type="Gramene" id="KVI07527">
        <property type="protein sequence ID" value="KVI07527"/>
        <property type="gene ID" value="Ccrd_014066"/>
    </dbReference>
    <dbReference type="OMA" id="TPCLPDV"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36395">
        <property type="entry name" value="RING-H2 ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36395:SF1">
        <property type="entry name" value="RING-H2 ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="277" mass="30956" checksum="5EE58F74A9ABCFF3" modified="2016-04-13" version="1">MSPQPPPSITKPHPNSLSDFIFSAFSLFVCSSSSFKPTSNFNPPRRLFKFPIMPLTTTKTPAINNHHFPTPQSLSDWLRPRLPSDSFAAWGTRPGTKNIHNLWLELAEGETSLADSTPPVRTLEVVVVRVRDHQNRILIESHQQLSNGDIRDRSRPLSEKMKPGETVESAVVRAVKEELGSIIKDSCSNVNYGDIVKIIPNSYSSKVEERVSVSYPGLPACYVLHTVDAIVDGLPDCEFCSEEEEEYQDLDEKEGAKGAVSCKKHYWKWVDSNTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEK3</accession>
    <name>A0A103YEK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSL (TC 2.A.67.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEK3"/>
    <dbReference type="STRING" id="59895.A0A103YEK3"/>
    <dbReference type="Gramene" id="KVI07626">
        <property type="protein sequence ID" value="KVI07626"/>
        <property type="gene ID" value="Ccrd_014021"/>
    </dbReference>
    <dbReference type="OMA" id="KSICARM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051980">
        <property type="term" value="F:iron-nicotianamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF4">
        <property type="entry name" value="METAL-NICOTIANAMINE TRANSPORTER YSL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="55931" checksum="8B76BBFC5985A879" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFB7</accession>
    <name>A0A103YFB7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pleckstrin homology-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001377">
        <property type="protein sequence ID" value="KVI08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFB7"/>
    <dbReference type="STRING" id="59895.A0A103YFB7"/>
    <dbReference type="Gramene" id="KVI08045">
        <property type="protein sequence ID" value="KVI08045"/>
        <property type="gene ID" value="Ccrd_013589"/>
    </dbReference>
    <dbReference type="OMA" id="LVWFSHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="85" mass="9664" checksum="EDBEE10D8E886690" modified="2016-04-13" version="1" fragment="single">MMLLQTPRMTSDASRTGGQVERDIEQAITALKKGAYLLKYGRRGKPKFCPFRLANDESVLIWFSGKEEKHLKLSHVSRIVSGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFE0</accession>
    <name>A0A103YFE0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_013539</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Defense against chitin-containing fungal pathogens.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001315">
        <property type="protein sequence ID" value="KVI08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFE0"/>
    <dbReference type="STRING" id="59895.A0A103YFE0"/>
    <dbReference type="Gramene" id="KVI08093">
        <property type="protein sequence ID" value="KVI08093"/>
        <property type="gene ID" value="Ccrd_013539"/>
    </dbReference>
    <dbReference type="OMA" id="INGAYEC"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.10:FF:000003">
        <property type="entry name" value="Class IV chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.20.10:FF:000001">
        <property type="entry name" value="Endochitinase (Chitinase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000052">
        <property type="entry name" value="Endochitinase PR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.20.10">
        <property type="entry name" value="Endochitinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF193">
        <property type="entry name" value="ENDOCHITINASE EP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00773">
        <property type="entry name" value="CHITINASE_19_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00774">
        <property type="entry name" value="CHITINASE_19_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 16" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 15 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119665" description="chitinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="18">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15 16">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15 16">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="28823" checksum="92914624ED4013C2" modified="2016-04-13" version="1">MKIFSFLIVIGVLSAGILQIAAQNCGCSPDLCCSRFGYCGSDDAYCGAGCQEGPCFGPPPTNNVSVGSIVTDEFFNAIVEQSDGGCEGRGFYSRAAFLDAVGNYPQFGRVGSEQDSRREIAAFFAHVTHETGHFCYIEEINGPSRDYCDEGNTQFPCNPSKGYYGRGPIQLSWNYNYGPAGRSIGFDGLNNPEIVATDPRISFQTALWFWMNNVHSLLISGQGFGATIRAINGGECDGGNPATVSSRVGYYTEYCNQLGVAPGDNLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFM7</accession>
    <name>A0A103YFM7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001187">
        <property type="protein sequence ID" value="KVI08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFM7"/>
    <dbReference type="STRING" id="59895.A0A103YFM7"/>
    <dbReference type="Gramene" id="KVI08224">
        <property type="protein sequence ID" value="KVI08224"/>
        <property type="gene ID" value="Ccrd_013405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657:SF1">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="69" mass="7900" checksum="ADC4A5377AB1C1F7" modified="2016-04-13" version="1">MIYRNIMGGEGGGLSLKAFANAKTKTDGYNAALIKKQREFYKNAKYVNKYKKSLKQQNHKHVLPKLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG72</accession>
    <name>A0A103YG72_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Breast carcinoma amplified sequence 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001111">
        <property type="protein sequence ID" value="KVI08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG72"/>
    <dbReference type="Gramene" id="KVI08502">
        <property type="protein sequence ID" value="KVI08502"/>
        <property type="gene ID" value="Ccrd_013126"/>
    </dbReference>
    <dbReference type="OMA" id="NFGWLNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022175">
        <property type="entry name" value="BCAS3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12490">
        <property type="entry name" value="BCAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="4">
        <location>
            <begin position="80"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="BCAS3" evidence="3">
        <location>
            <begin position="613"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="959" mass="105912" checksum="6F75C36BC82AF593" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGX5</accession>
    <name>A0A103YGX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001082">
        <property type="protein sequence ID" value="KVI08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGX5"/>
    <dbReference type="STRING" id="59895.A0A103YGX5"/>
    <dbReference type="Gramene" id="KVI08875">
        <property type="protein sequence ID" value="KVI08875"/>
        <property type="gene ID" value="Ccrd_012754"/>
    </dbReference>
    <dbReference type="OMA" id="IFVWGTG"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF385">
        <property type="entry name" value="ULTRAVIOLET-B RECEPTOR UVR8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="42417" checksum="879ACA6011099D73" modified="2016-04-13" version="1">MAVNTTAVIAWGSGEDGQLGLGDNEEKEWVSSITSLNSVTVRSVVAGSRNSLAICDDGKLFMWGWNQRGTLGHQPSTKTENIPSQVKALDDVNIVQAAIGGWHCLAVDDQGRAYAWGGNEYGQCGEELEKKGDSGRTLRRDIVIPQRCASKLSVRQVAAGGTHSVVLTREGHVWTWGQPWPPGDIKQISTPVRVQGLERVKLIAVGAFHNLALVEDGNLWVWGNNEYGQLGTGDTQPRSQPVPVQGLSGLTLVDVAAGGWHSTALTDEGEVYGWGRGEHGRLGFGDDKSSKMVPQQVQLLAEEDIVQVSCGGTHSVALTRDGRMFSFGRGDHGRLGYGRKVTTGHPSEVPIDLPPPEDDESGSEVGRWCATYVACGGRHTIAIVEWQTTGPNPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHI6</accession>
    <name>A0A103YHI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAP30-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YHI6"/>
    <dbReference type="Gramene" id="KVI09187">
        <property type="protein sequence ID" value="KVI09187"/>
        <property type="gene ID" value="Ccrd_012442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="213" mass="23711" checksum="7C67EAFB0B6FC17B" modified="2016-04-13" version="1">MKVGVTYREIKTNSWTAASSAVYELIKGYAIWMVAANRGKKVGLFQFPSPPTTRDGQPTMKEEIRNSSASHGGVTKCDSKSSPPSKKSKTFPAIAAADDDVRFIEKPVPADQARAKWPXRYESKTPSFYVEESDTNEKCRLHAIHALVSHFHEMCAKVGVDPLASNKGFWAELLGIGDFYYELGTCLFLLLLLGPHNRGFINLEELCKLLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI10</accession>
    <name>A0A103YI10_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001060">
        <property type="protein sequence ID" value="KVI09485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI10"/>
    <dbReference type="STRING" id="59895.A0A103YI10"/>
    <dbReference type="Gramene" id="KVI09485">
        <property type="protein sequence ID" value="KVI09485"/>
        <property type="gene ID" value="Ccrd_012145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="72" mass="8164" checksum="87CAD889533EE3A9" modified="2016-04-13" version="1">MSVNYQERFSAAVEDFLKGREGQRIMRLIDRPLRPTMLKGFYHETQILSWVLSYDGLHPPDSLAVTAAGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI35</accession>
    <name>A0A103YI35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001057">
        <property type="protein sequence ID" value="KVI09515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI35"/>
    <dbReference type="STRING" id="59895.A0A103YI35"/>
    <dbReference type="Gramene" id="KVI09515">
        <property type="protein sequence ID" value="KVI09515"/>
        <property type="gene ID" value="Ccrd_012082"/>
    </dbReference>
    <dbReference type="OMA" id="VKHHINE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF70">
        <property type="entry name" value="MAJOR ALLERGEN PRU AR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="57"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="21369" checksum="F9128B4F1D313749" modified="2016-04-13" version="1">MGVLTYTDEHTSSVSPARTFKASIVDSHNLMPKLLPDATKSINIVKGDGGAGSIKENSHNLMPKLLPEAIKSISFIKGDGGAGSIKEIKFAGRKVIFNPIYFVKHHINELNEKTLTYKYTLIEGEGISDKIEKVSYDIKFEGSPDGGTISKMTTTIYTHGDFELKEKLKAGKEEVLGLYKVVEVYLLKNPDAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK70</accession>
    <name>A0A103YK70_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_010935</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001005">
        <property type="protein sequence ID" value="KVI10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK70"/>
    <dbReference type="STRING" id="59895.A0A103YK70"/>
    <dbReference type="Gramene" id="KVI10661">
        <property type="protein sequence ID" value="KVI10661"/>
        <property type="gene ID" value="Ccrd_010935"/>
    </dbReference>
    <dbReference type="OMA" id="FFAYMGN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000001">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119802" description="glucan endo-1,3-beta-D-glucosidase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="19">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="487" mass="52248" checksum="78BC92FC994F0119" modified="2016-04-13" version="1">MAVAPLLSLFLLAIFTFADAGSIGVNYGRIANNLPSPSKVVNLIKSQGIHRVKVYDTDPAVLKSLAGSGIKVTVDLPNELLSAAAKKQSFAYKWVERNVAVYHPHTQIEAIAVGNEVFVDPKNTTGFLVPAMKNLHQALVKFNLHSDIKISSPVALSALQSSYPSSAGSFRTELIEPVFKPMFELLRQTGSYLMVNAYPYFAYESNSDVISLDYALFRENPGVPDGGNGLRYFSLFDAQIDAVFAAMSAMKYDDIPLVVTETGWPSKGDENEVGASVENAAAYNGNLVKRILTGAGTPLRPKADLTVFLFALFNENNKNGPSSERNYGLFYPNQQKVYNVPFTAEDLKDYRDKQSPVTGDVGGGQVRVSTPTNGSVSGQTWCVASDVGKERLQVALDYACGEGGADCRSIQPGSTCYDPNTVEAHASFAFNSYYQKTGRAAGSCYFGGAAHTNMGNVSSPQAIEEGEGEGEGEGEGEGEGEGEGSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKN2</accession>
    <name>A0A103YKN2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000993">
        <property type="protein sequence ID" value="KVI10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKN2"/>
    <dbReference type="Gramene" id="KVI10842">
        <property type="protein sequence ID" value="KVI10842"/>
        <property type="gene ID" value="Ccrd_010756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13620" checksum="3FF6832EF2883054" modified="2016-04-13" version="1">MGKTATLHKDTRHQRTHNRAILLKAIHNNSILLSTPHSTQLLLLSSKNKAVSGCPVLLLSLGCMLLEEGLNWYIGVSSYRKLDSRTWTFVLLLVITCDLKRDSRMYLSHRSFVLLFVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKZ1</accession>
    <name>A0A103YKZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000968">
        <property type="protein sequence ID" value="KVI10988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKZ1"/>
    <dbReference type="Gramene" id="KVI10988">
        <property type="protein sequence ID" value="KVI10988"/>
        <property type="gene ID" value="Ccrd_010607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="14016" checksum="52DBB1B9A99911C9" modified="2016-04-13" version="1" fragment="single">DEDDSLTKKTIYSSKGVFLLPVVFATSVKLSLEGEPELELLFLTPTMPEEVPLVLHLEPQALHSTGFSGGPFLHNGVSVQHSNPSVSWRIHFTLRHCRMKGAIAAAFACDQVHYHVVFITHSAHEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLL7</accession>
    <name>A0A103YLL7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ulp1 protease family, C-terminal catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000134">
        <property type="protein sequence ID" value="KVI11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLL7"/>
    <dbReference type="Gramene" id="KVI11420">
        <property type="protein sequence ID" value="KVI11420"/>
        <property type="gene ID" value="Ccrd_010169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="74028" checksum="F9A53F4339EBEF56" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMK0</accession>
    <name>A0A103YMK0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000034">
        <property type="protein sequence ID" value="KVI11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMK0"/>
    <dbReference type="Gramene" id="KVI11844">
        <property type="protein sequence ID" value="KVI11844"/>
        <property type="gene ID" value="Ccrd_009740"/>
    </dbReference>
    <dbReference type="OMA" id="FKWINAT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13005" checksum="8C15D555F87E74C2" modified="2016-04-13" version="1">MISFNVDPICPTLAGRHPPRSLFAKTSTDTGELPKFGGIPNLNRLSFKKTASRSLSNSLTGTDPSNSLNRRSKNFNTGIDKTTVGKTPTKRLLLISSSWRSLSFLKVAGTVPQNRLELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMT6</accession>
    <name>A0A103YMT6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipid methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000024">
        <property type="protein sequence ID" value="KVI11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMT6"/>
    <dbReference type="STRING" id="59895.A0A103YMT6"/>
    <dbReference type="Gramene" id="KVI11952">
        <property type="protein sequence ID" value="KVI11952"/>
        <property type="gene ID" value="Ccrd_009638"/>
    </dbReference>
    <dbReference type="OMA" id="NFSCWSP"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF11">
        <property type="entry name" value="PROTEIN C-TERMINAL S-ISOPRENYLCYSTEINE CARBOXYL O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="409" mass="47041" checksum="AA0C54C79E53CC90" modified="2016-04-13" version="1" fragment="single">MGSPVVVSLSANPCRLVTPKICRISLRHFNKQPVGQLSTDNTFKKTLQCPLLTATNRFSSRNRTHLVQPVRSSYSDTTNSIFNKPVLSNFENFSFDALKKTLYELNPIRVCKWVFLGSIAVASFKWGINTLLSPFFWMYFSWTWVFWPWCIAIGLAIYGIYGFSKHIKGEAGELEQLAIVTSAFTWLTLVPPGHANGFLEGWPFVFFFVYHYFFFLNVSIRKRLYGDFYPREHDPKWDIGTPIWCRVLFCVGVMAGHWFAAFEAPQLHLIPGGWSNLGIWGLIMSTVLLQYHSTLYLAKYSEKVVVPTAVVQFGPYRWIRHPIYASTGLLFLTYFIALRAPLSSLFIVAVCLMYYDQKAKLEEALMLETFGDGYTEYMKKMLSSGDDRRIVAQVFFEDVRIYRNSLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I2Q1</accession>
    <name>A0A118I2Q1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007583">
        <property type="protein sequence ID" value="KVG81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I2Q1"/>
    <dbReference type="Gramene" id="KVG81631">
        <property type="protein sequence ID" value="KVG81631"/>
        <property type="gene ID" value="Ccrd_026184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="13565" checksum="1E60959514FC8ED7" modified="2016-04-13" version="1">MQEVGDDPVDLKMKILSTPTMDINGARQLMHRAILVVRSLQLFSAGNHGSSRVFRDTSYKSIVGSGGVGRGDKLDSDHTGRSKGRGKRGHDIGICKVREMVNSKFDEDSRGCVIWGSFRFPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTR0</accession>
    <name>A0A118JTR0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005067">
        <property type="protein sequence ID" value="KVH91224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTR0"/>
    <dbReference type="STRING" id="59895.A0A118JTR0"/>
    <dbReference type="Gramene" id="KVH91224">
        <property type="protein sequence ID" value="KVH91224"/>
        <property type="gene ID" value="Ccrd_006755"/>
    </dbReference>
    <dbReference type="OMA" id="PQRMESC"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="267" mass="29974" checksum="39E3D5D4E366B049" modified="2016-04-13" version="1">MIRSSSRSLYKLRALCRSSSSVPSYRSPLSSPITATAIRRFTADLGIGNKRETGYFSSLVSLQSRFHVSRVNGASKVSSFETRSFASRASRSKSENASETRKEVSTVEDPFDAPTYNIPEKPMTFTEGASYSVVILIGLGIAAAAGYGVFKELIFEPKEYKVFNKALRRIQDDSQVSVRIGSPITGYGQESRNRAARQRIPNRVWKDDEGVEHVEVNFYIRGPHGAGKVFSEMFKDKEDKQWKFMYLQVEIHSPSPSRMLLESYIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUF0</accession>
    <name>A0A118JUF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-fructofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_006041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004897">
        <property type="protein sequence ID" value="KVH91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUF0"/>
    <dbReference type="STRING" id="59895.A0A118JUF0"/>
    <dbReference type="Gramene" id="KVH91931">
        <property type="protein sequence ID" value="KVH91931"/>
        <property type="gene ID" value="Ccrd_006041"/>
    </dbReference>
    <dbReference type="OMA" id="IESFAMG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="126"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="575" mass="64574" checksum="327759D6216E2EFD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVJ5</accession>
    <name>A0A118JVJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metalloenzyme, LuxS/M16 peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003808</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004568">
        <property type="protein sequence ID" value="KVH94149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVJ5"/>
    <dbReference type="STRING" id="59895.A0A118JVJ5"/>
    <dbReference type="Gramene" id="KVH94149">
        <property type="protein sequence ID" value="KVH94149"/>
        <property type="gene ID" value="Ccrd_003808"/>
    </dbReference>
    <dbReference type="OMA" id="INQVMEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="171"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="358"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="716"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="804" mass="92247" checksum="74A4124B95B273DD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWF0</accession>
    <name>A0A118JWF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004383">
        <property type="protein sequence ID" value="KVH95529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWF0"/>
    <dbReference type="STRING" id="59895.A0A118JWF0"/>
    <dbReference type="Gramene" id="KVH95529">
        <property type="protein sequence ID" value="KVH95529"/>
        <property type="gene ID" value="Ccrd_002393"/>
    </dbReference>
    <dbReference type="OMA" id="AKYEVVT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF590">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="36552" checksum="36989B6B3AA05A8C" modified="2016-04-13" version="1">MAASLSLPLIDLSSTDRISTANSIRQVLFLSLTEYAIRDLSFYSRTTLQLEGVIASMDYGFFYLINHGVDEQLLQNVFDESRKFFSLPLEEKMKLARKGDLGFAPMRAENLDSSTTSKGDSKETFHIGPSEDDERHINQWPSEDVLPSWRFVMEKYYKQVLSTGKQLSSLIALALNLDENFFEKAGGALNGESAVLRLLHYPGEMGVSDEVVYGASAHSDYGMITLLATDGVPGLQATFINISFVCREKLKQPRIWEDVNHVKGSTLHRVMPTGKERYSIALFLDPNEDYIVECLPSCCSESSPPRFPPIRCGDYLRDRIDAAYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWM6</accession>
    <name>A0A118JWM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004551">
        <property type="protein sequence ID" value="KVH94510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWM6"/>
    <dbReference type="STRING" id="59895.A0A118JWM6"/>
    <dbReference type="Gramene" id="KVH94510">
        <property type="protein sequence ID" value="KVH94510"/>
        <property type="gene ID" value="Ccrd_003409"/>
    </dbReference>
    <dbReference type="OMA" id="MMMKIAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33702">
        <property type="entry name" value="BNAA09G40010D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33702:SF5">
        <property type="entry name" value="OS01G0308600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="14949" checksum="3871941C09F26529" modified="2016-04-13" version="1">MEGLTTRVYKGVKGYWRRRRYQRLGTTTAPKRRTKWRIRISPRLKLRVSPKRLFAGVRDAYVRLMIKMANSPVVRCRTMSNGHDGEGFGTTARKEYDEKMIIEIYKTLAMRQGQLVTQQIPSQIACLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWT8</accession>
    <name>A0A118JWT8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004362">
        <property type="protein sequence ID" value="KVH96084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWT8"/>
    <dbReference type="Gramene" id="KVH96084">
        <property type="protein sequence ID" value="KVH96084"/>
        <property type="gene ID" value="Ccrd_001831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="15406" checksum="3638A98681F21B0B" modified="2016-04-13" version="1" fragment="single">MDRYYQRLKDDPLYFYKEKLQDSVHHDELSSSLLTVSVASSIAILGFCFALTYRLHRLFHFHPSPSPSRLLHFHQSPSPLPPPSPSLSLSPTVVVTSPLLSVTVVVSVSVAFSQGASLFFNPLLHRRGSNAFVVLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY77</accession>
    <name>A0A118JY77_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Negative regulator of systemic acquired resistance SNI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003875">
        <property type="protein sequence ID" value="KVH97044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY77"/>
    <dbReference type="STRING" id="59895.A0A118JY77"/>
    <dbReference type="Gramene" id="KVH97044">
        <property type="protein sequence ID" value="KVH97044"/>
        <property type="gene ID" value="Ccrd_000869"/>
    </dbReference>
    <dbReference type="OMA" id="CIAMQKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002215">
        <property type="term" value="P:defense response to nematode"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010113">
        <property type="term" value="P:negative regulation of systemic acquired resistance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016444">
        <property type="term" value="P:somatic cell DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034561">
        <property type="entry name" value="SNI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37243">
        <property type="entry name" value="NEGATIVE REGULATOR OF SYSTEMIC ACQUIRED RESISTANCE SNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37243:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SYSTEMIC ACQUIRED RESISTANCE SNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47639" checksum="0643DD1C16201227" modified="2016-04-13" version="1">MGTKRRRRGDGGMEENTMAILDTSCFSKSTQHVADDRLSFLEAVRSGFLVPENASAPTNKMYKAIFQILKVENSLDLIMSSYQLLLELDKRFPQVSLSVAEKSESSSPSSPQRNELVVVEEAWSPFSFGPDVSSCEKQDLDKVGGSLDAIAFHLLIGDLAKVAEEANTKTLDSKPLRNMLLFQYLVNVLEGDFVPRNLAFSESFDWIYVRESLLNMILVSRKIAYKGLIQDCLSAIFELSQFSMDCSHDVRSPETKLEEVTGKRHTAFALALPEIVKCTCVAVQKLLLMIIELDSSKKAADMEGQTTRADGALDKPRLKLDMIVQYLLKYIPKTSVRTRRSNGSTNDSTFGGVLKCFSNGNSTKSIVKKISTEVAQLLLAQAFQAYISLPSQHSTEYKEDIAGNSLPEICNSMISAFTCLKKTNESKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYS0</accession>
    <name>A0A118JYS0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MIZU-KUSSEI 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003795">
        <property type="protein sequence ID" value="KVH98472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYS0"/>
    <dbReference type="STRING" id="59895.A0A118JYS0"/>
    <dbReference type="Gramene" id="KVH98472">
        <property type="protein sequence ID" value="KVH98472"/>
        <property type="gene ID" value="Ccrd_023322"/>
    </dbReference>
    <dbReference type="OMA" id="NTHDFAS"/>
    <dbReference type="OrthoDB" id="1859415at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010274">
        <property type="term" value="P:hydrotropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006460">
        <property type="entry name" value="MIZ1-like_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01570">
        <property type="entry name" value="A_thal_3588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696">
        <property type="entry name" value="PROTEIN MIZU-KUSSEI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696:SF23">
        <property type="entry name" value="PROTEIN MIZU-KUSSEI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04759">
        <property type="entry name" value="DUF617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28636" checksum="5E0D79EF6FCD0F0D" modified="2016-04-13" version="1">MAKTCMQDKKHFHWSNKVSNEDEEQYQESPPPPPPLSSFNSCPKSNTTDQPSLTRKKLQAVTIARFRSVVTALTKNRTSLLNGLGPRVVGTLFGSRRGHVYFAFQKNPTSQPAFLIELQTPISGLVKEMASGLVRIALECDKEDKTAVKKVGNTRRLLEEPVWRTYCNGKKCGFAMKRECGEKEWRVLKAVEPISMGAGVLPAPEKKVAGEEEDGGVMYMRAKFERVMGSRDSEAFYMMNPDSNGAPELSVYLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ17</accession>
    <name>A0A118JZ17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003583">
        <property type="protein sequence ID" value="KVH99369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JZ17"/>
    <dbReference type="Gramene" id="KVH99369">
        <property type="protein sequence ID" value="KVH99369"/>
        <property type="gene ID" value="Ccrd_022400"/>
    </dbReference>
    <dbReference type="OMA" id="RWFFSSK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20653">
        <property type="entry name" value="CYP81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000026">
        <property type="entry name" value="Cytochrome P450 82C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF24">
        <property type="entry name" value="ISOFLAVONE 2'-HYDROXYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="527" mass="61120" checksum="EC4B44C5D526504B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZC1</accession>
    <name>A0A118JZC1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_022489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003625">
        <property type="protein sequence ID" value="KVH99277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZC1"/>
    <dbReference type="STRING" id="59895.A0A118JZC1"/>
    <dbReference type="Gramene" id="KVH99277">
        <property type="protein sequence ID" value="KVH99277"/>
        <property type="gene ID" value="Ccrd_022489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08602">
        <property type="entry name" value="GDPD_ScGlpQ1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000023">
        <property type="entry name" value="Glycerophosphodiester phosphodiesterase GDPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159817" description="glycerophosphodiester phosphodiesterase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="12">
        <location>
            <begin position="43"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="13">
        <location>
            <begin position="427"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH99277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="607" mass="67562" checksum="C48F5859AF4517A2" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ2</accession>
    <name>A0A118JZZ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ2"/>
    <dbReference type="STRING" id="59895.A0A118JZZ2"/>
    <dbReference type="Gramene" id="KVI00393">
        <property type="protein sequence ID" value="KVI00393"/>
        <property type="gene ID" value="Ccrd_021376"/>
    </dbReference>
    <dbReference type="OMA" id="ENGSRCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF149">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 33, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="30778" checksum="C2ECE03C24491858" modified="2016-04-13" version="1">MASQFIREWSGIQQFPLATQEKLLELLGRLKEKKKDRLTILVMGKGGVGKSSTVNSIIGERAVTVNAFQSETPRPTMVSRERFLLNKTIDVLLYVDRLDAYRVDSLDVKIVKAISNSFGQEIWHRAIIVLTHAQLSPPDCLSYDEFLARRSEALLKVVHLGARFKKKDIQKFSIPVGLVENSSRCNKNDKDEKILPNGTAWIPSIVETITKVALTDSKCILVDQKLIDGPNPNDRGKLFIPLILAFQYFFVLQPLQRSIKTDVENAVKSKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0B5</accession>
    <name>A0A118K0B5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003133">
        <property type="protein sequence ID" value="KVI01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0B5"/>
    <dbReference type="STRING" id="59895.A0A118K0B5"/>
    <dbReference type="Gramene" id="KVI01082">
        <property type="protein sequence ID" value="KVI01082"/>
        <property type="gene ID" value="Ccrd_020659"/>
    </dbReference>
    <dbReference type="OMA" id="ICNDMHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10656" checksum="2A2855BD4358DAA5" modified="2016-04-13" version="1">MSEIDLQIPTAFDPFAEANAEDSSAGSKEYVHIRIQQRNGRKSLTTVQGLKKDFSYNKILKDLKKEFCCNGTVVQDPELGQAGIVKKDRIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2A6</accession>
    <name>A0A118K2A6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002314">
        <property type="protein sequence ID" value="KVI04052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2A6"/>
    <dbReference type="STRING" id="59895.A0A118K2A6"/>
    <dbReference type="Gramene" id="KVI04052">
        <property type="protein sequence ID" value="KVI04052"/>
        <property type="gene ID" value="Ccrd_017656"/>
    </dbReference>
    <dbReference type="OMA" id="RIWGAPF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF45">
        <property type="entry name" value="PROTEIN DETOXIFICATION 45, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="566" mass="60892" checksum="B40700E403F5C913" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K375</accession>
    <name>A0A118K375_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K375"/>
    <dbReference type="Gramene" id="KVI05478">
        <property type="protein sequence ID" value="KVI05478"/>
        <property type="gene ID" value="Ccrd_016155"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914915at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22170" checksum="A5896A760CD1C3B1" modified="2016-04-13" version="1">MESNGYVHGESSLNQECITRKLDFSDDKEVSWCPYFGFDEPHSGKYIMKRWKENIITTNLLRTRNCLGEIDRGYRNELAHDTHSAVDYCIDILSRDKKKLEAFASKIHDLKCEVEAEFLNSLNYNSKKEMAESFLGYEFGEITIRNPPVRRNRWEEAIVESSKRKRMCRRCMELSTHDSRNCPLKNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3F6</accession>
    <name>A0A118K3F6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001859">
        <property type="protein sequence ID" value="KVI05898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3F6"/>
    <dbReference type="STRING" id="59895.A0A118K3F6"/>
    <dbReference type="Gramene" id="KVI05898">
        <property type="protein sequence ID" value="KVI05898"/>
        <property type="gene ID" value="Ccrd_015741"/>
    </dbReference>
    <dbReference type="OMA" id="YQQVEYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000003">
        <property type="entry name" value="GDSL esterase/lipase APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF35">
        <property type="entry name" value="GDSL ESTERASE_LIPASE APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159916" evidence="2">
        <location>
            <begin position="36"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="339" mass="36216" checksum="1C338693B2FA7C8C" modified="2016-04-13" version="1">MGRKSFFMDSITTIPPWTPLLLSLVAAILISSGEAQDSTTLVPAIFAFGDSAVDVGNNDYLPTIFKANYPPYGRDFVNHQPTGRFCNGKLATDITADTLGFTTYPPAYLSPEATGKNLLIGANFASAGSGYDDKTAIGSLQYYKEYQTKLQQVAGSGKAASIIKDALYLISAGNSDFVQNYYVNPFVNKDLHGLGARRIGVTSLPPLGCLPAVRTLFGYHEKGCVAKMNTDAQAFNKKVNAAATQLGKELPGLKIAIFDIFQPLYDLVKDPSSHGFVEATRGCCGTGRVETTVLLCNPKSIGTCSNATQFVFWDSVHPSEAANQVLADALILQGISLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6B9</accession>
    <name>A0A118K6B9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6B9"/>
    <dbReference type="STRING" id="59895.A0A118K6B9"/>
    <dbReference type="Gramene" id="KVI10438">
        <property type="protein sequence ID" value="KVI10438"/>
        <property type="gene ID" value="Ccrd_011186"/>
    </dbReference>
    <dbReference type="OMA" id="NNCTSIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08604">
        <property type="entry name" value="GDPD_SHV3_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000011">
        <property type="entry name" value="Glycerophosphodiester phosphodiesterase GDPDL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007160007" description="glycerophosphodiester phosphodiesterase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="10">
        <location>
            <begin position="35"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="10">
        <location>
            <begin position="312"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="719" mass="78523" checksum="80608D9D06954721" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6X9</accession>
    <name>A0A118K6X9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_010205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000229">
        <property type="protein sequence ID" value="KVI11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6X9"/>
    <dbReference type="STRING" id="59895.A0A118K6X9"/>
    <dbReference type="Gramene" id="KVI11385">
        <property type="protein sequence ID" value="KVI11385"/>
        <property type="gene ID" value="Ccrd_010205"/>
    </dbReference>
    <dbReference type="OMA" id="VYLWIES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="267" mass="30514" checksum="15C6C15B270A25F2" modified="2016-04-13" version="1" fragment="single">MVDNGGFWSRLLLCDCYGSILLLISSLQTFPKAFTDSSPSSPSSTFSPSFPSSTFTIAVATFFTWLANFKLLFTFNHGPLYPPKSLIQFIVVTFLPVKIKPQFFNPKNKSSVYLWIESMLFPLLINFAYNYKHELNPHVLLIVYCFIMFILIDLLVFVSNAVIGAVAGVELEPLLDLPSPLDEPYLLTSLQDFWGRRWNLMPAHTVYKPVKYVLPAKEWATAMAVMATFIVSGLMHELMFYYVIPVSPTWEMSFFVFHGIRLIMELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K711</accession>
    <name>A0A118K711_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein BIG GRAIN 1-like B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_010069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in auxin transport. Regulator of the auxin signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BIG GRAIN 1 (BG1) plant protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000096">
        <property type="protein sequence ID" value="KVI11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K711"/>
    <dbReference type="STRING" id="59895.A0A118K711"/>
    <dbReference type="Gramene" id="KVI11520">
        <property type="protein sequence ID" value="KVI11520"/>
        <property type="gene ID" value="Ccrd_010069"/>
    </dbReference>
    <dbReference type="OMA" id="EEDTRVM"/>
    <dbReference type="OrthoDB" id="680041at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039621">
        <property type="entry name" value="BG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541:SF12">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40560" checksum="931EAD1675387268" modified="2016-04-13" version="1">MYGRNHKSVRETKSKKNTQNPSFSSTLLDEIYRSMDGGDEKSSEFKLREEKQSVGARAKASSVVEDEGMASHRRPFLVEKWMDMKTFTGRTRPSTLPEFHRKLALDNDPVFLSSGSSSSDSSFGWFSEPDGFCDSRSHKPSCFSKPKPIKTDAFSKKHQKMELDYCSNDDQTTNGALIKSKSRALKIYANLKKVKHPISPGGRLTTFLNSLFANGNVKKPKDSNSSGFDNKKIIERTTHGSTCSSASSFTRSCLSKNSPRSREKLNNGIRRTVRFYPVSVIIDQDSRPCGKKFIRDEEDFTKYNEDDDYSYDEDTSSDSSSDLFELDHLSILKERDEELPVYETTHFGTNRAIANGLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7A2</accession>
    <name>A0A118K7A2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neutral ceramidase</fullName>
            <ecNumber evidence="15">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_009661</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01000025">
        <property type="protein sequence ID" value="KVI11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7A2"/>
    <dbReference type="STRING" id="59895.A0A118K7A2"/>
    <dbReference type="Gramene" id="KVI11923">
        <property type="protein sequence ID" value="KVI11923"/>
        <property type="gene ID" value="Ccrd_009661"/>
    </dbReference>
    <dbReference type="OMA" id="FACILNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000002">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007160025" description="Neutral ceramidase" evidence="16">
        <location>
            <begin position="34"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="17">
        <location>
            <begin position="37"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="18">
        <location>
            <begin position="563"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="727" mass="79752" checksum="ABC3B0F3BDB26CF3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB78</accession>
    <name>A0A124SB78_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystic fibrosis transmembrane conductance regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005138">
        <property type="protein sequence ID" value="KVH89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB78"/>
    <dbReference type="STRING" id="59895.A0A124SB78"/>
    <dbReference type="Gramene" id="KVH89800">
        <property type="protein sequence ID" value="KVH89800"/>
        <property type="gene ID" value="Ccrd_008201"/>
    </dbReference>
    <dbReference type="OMA" id="EHPMEPL"/>
    <dbReference type="OrthoDB" id="1909326at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34196">
        <property type="entry name" value="OS02G0697700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34196:SF2">
        <property type="entry name" value="OS02G0697700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16876" checksum="1B94839CC0AB2C04" modified="2016-04-13" version="1">MVGLFSRFSVSRNGHRRSQTSIDEREVLPPDTEVTESSTVVGATTTTHHGIEVAIEFKPVEHPTEPLDNDQPVNCPLPEPSILNDGRIWKERVSAGVQRRADLSAVDEGAAPPPEPEPPGNKSQRRTNRMILPSISAPEHNILKLLEECNASGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCK2</accession>
    <name>A0A124SCK2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_003947</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCK2"/>
    <dbReference type="STRING" id="59895.A0A124SCK2"/>
    <dbReference type="Gramene" id="KVH93987">
        <property type="protein sequence ID" value="KVH93987"/>
        <property type="gene ID" value="Ccrd_003947"/>
    </dbReference>
    <dbReference type="OMA" id="RNCDGIV"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01563">
        <property type="entry name" value="Thr-synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000030">
        <property type="entry name" value="Threonine synthase 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0934">Plastid</keyword>
    <keyword evidence="14 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="20">
        <location>
            <begin position="143"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="18">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH93987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="561" mass="61716" checksum="25D908264BA22D67" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE53</accession>
    <name>A0A124SE53_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE53"/>
    <dbReference type="STRING" id="59895.A0A124SE53"/>
    <dbReference type="Gramene" id="KVH99026">
        <property type="protein sequence ID" value="KVH99026"/>
        <property type="gene ID" value="Ccrd_022717"/>
    </dbReference>
    <dbReference type="OMA" id="NHKARTY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="5">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="5">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33459" checksum="4CB8C511880DCE99" modified="2016-04-13" version="1" fragment="single">QRNHKARTYTHTHTLSLCFRRCILRRQLVYLAGGSDLRTTPVVAPPSPSGQQSNNNLSRRRTASSSSSSSRPSPSGPTRIIYRETLRPSSSSESDLDLPVWQRTWFIVLLFAMALSFFGLAIVLFLTLDSDYTSSSVYAANSEGVEITYGSVIKLMHEKTKFRLHSHDVPYGSGSGQQSVTGFPNIVRPMLETSVKQGDNIKGGTIIRLQHMKTRKWLHSHLHASPISGNLEVSCFGDEGNSDTGDYWRVEIEGSGKTWRQDQRIRLRHVCGVREKRADNVWLAAEGIYFPTAESKATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFK3</accession>
    <name>A0A124SFK3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01002345">
        <property type="protein sequence ID" value="KVI03527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFK3"/>
    <dbReference type="STRING" id="59895.A0A124SFK3"/>
    <dbReference type="Gramene" id="KVI03527">
        <property type="protein sequence ID" value="KVI03527"/>
        <property type="gene ID" value="Ccrd_018156"/>
    </dbReference>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000004">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="332" mass="34684" checksum="446DFE51051DCA13" modified="2016-04-13" version="1">MLAAKILLPGPSISQTLTFPSPSIKPSSFKSSCLKSSSQSVLTETLSITPSKTRVKILSEALPFIQKFRGKTVVVKYGGAAMKSEALQSSVITDLVLLSCIGLRIVFVHGGGPEINQWLNRLGIKPSFLNGLRVTDASTMEIVSMVLVGKVNKHLVGLINKAGATAVGLCGTDGRIFTASPSPNSDQLGFVGEISSVDTSVLRPLINDNLIPVIASVAADGTGQSYNINADTAAGELAAALGAEKLLLLTDVAGILEDKDDPESLVKEIDVKGVKKMMEDGKIAGGMIPKVNCCVRSLTQGVKTASIIDGRLEHSLLLEVLTDEGAGTMITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG07</accession>
    <name>A0A124SG07_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_016744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001899">
        <property type="protein sequence ID" value="KVI04922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG07"/>
    <dbReference type="STRING" id="59895.A0A124SG07"/>
    <dbReference type="Gramene" id="KVI04922">
        <property type="protein sequence ID" value="KVI04922"/>
        <property type="gene ID" value="Ccrd_016744"/>
    </dbReference>
    <dbReference type="OMA" id="MINTEHW"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF351">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI04922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="32098" checksum="3B892F092A23E60D" modified="2016-04-13" version="1">MVFSSLPSYLDPPNWPQQQQVGGVGGDHEISQLPPPLLPPPPPLGSGGDARSVQMSERARMGKLPQPETAMKCPRCESTNTKFCYFNNYSLSQPRHFCKTCRRYWTRGGALRNVPVGGGCRRNKKSSKGSRGSRSKSPSATTSSTSNTAISPNSCTTDILGHLPHNTRPSQFPILPPLNHFGGGDLGLTFAGGNGNNLIHLGHDSNYPSNKFAQFPFLEAANAGMYGEGPSNYGGQVGGMKMEDNHHRHHQQQGLNLSRNFMDIPGNEQFLGTSNVAWSTTDLSGFNSSSTTTTHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGF4</accession>
    <name>A0A124SGF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGF4"/>
    <dbReference type="STRING" id="59895.A0A124SGF4"/>
    <dbReference type="Gramene" id="KVI06228">
        <property type="protein sequence ID" value="KVI06228"/>
        <property type="gene ID" value="Ccrd_015415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23284" checksum="F8F352D1F83FBB12" modified="2016-04-13" version="1">MFQGKETIERSRVKEFTWVLEEESHARSRDCSTNAIERRRKGVCNQATISVRKNNHTRGLRIREVGSNTSICSAKMTTGFVHSARRVITASSSSYWRSFSSPPSNNKLFVAGLSWSVDEKSLKEAFSTFGEVSEVRIMYDKDSGRSRGFGFVNFSKEDEASSAKDSMDGKAFLGRPLRVCFALDKVHREPVSPRQNNHGTTFIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGM5</accession>
    <name>A0A124SGM5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001562">
        <property type="protein sequence ID" value="KVI06857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SGM5"/>
    <dbReference type="Gramene" id="KVI06857">
        <property type="protein sequence ID" value="KVI06857"/>
        <property type="gene ID" value="Ccrd_014783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25398" checksum="9A45446FA6FD6B68" modified="2016-04-13" version="1" fragment="single">LESPVTPTSSLGSLVSIKRGHGKNRFKITINSFFKSCCEPCNRRPFRAILAESEFAAPTITKLIPIPFSTSGASVAYNVNPVADQFQRAFQTSTFCNRLYSFFNKRXFFDQSDRSCVSDMKFQNRKKKRFFAQLAHSAGPTCISYLAEEASDRLDFLPSWDSMDQDLLLLYGQYRSTLVDHMDVEKASHFDELETSLFHFYLPSSYLCFVCSPEEFDHLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH27</accession>
    <name>A0A124SH27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001199">
        <property type="protein sequence ID" value="KVI08207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH27"/>
    <dbReference type="STRING" id="59895.A0A124SH27"/>
    <dbReference type="Gramene" id="KVI08207">
        <property type="protein sequence ID" value="KVI08207"/>
        <property type="gene ID" value="Ccrd_013424"/>
    </dbReference>
    <dbReference type="OMA" id="RWWSDDS"/>
    <dbReference type="OrthoDB" id="785439at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35719">
        <property type="entry name" value="OS01G0680600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35719:SF5">
        <property type="entry name" value="T6K12.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="339" mass="38836" checksum="40064235D6D28FED" modified="2016-04-13" version="1">MSLDMRSNEPNENSNALVLSRIRGGLEVAVDNVFGRSQNELNLKSTIHRHYKQMVFLILLTRLHQSPPPLQLLLSHDQQLWPPIDRSAFFSINHTRMLRHRIHTKSRRWDSNAETFRTQNFDFNSTDEDDDDFEEEDDDDDDDTIQWLDILEDFIDGVWIFKVFRSFGWMLPAIISSLLLTSGPKAFLMALAIPLGQSVLSLVFQTVWGRPKNRTKSQGKKSKSKRRPPQPPPPQSAATSVDIDDEQEDKYMRGERKRAATGYQTWVAGDGGSSSNGSSSSFGGWEELDRRGGSKSNTDRRRKTSKSTLSRRERRSQTPLLLRLLIAVFPFLGSWTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHD8</accession>
    <name>A0A124SHD8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_012337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHD8"/>
    <dbReference type="STRING" id="59895.A0A124SHD8"/>
    <dbReference type="Gramene" id="KVI09242">
        <property type="protein sequence ID" value="KVI09242"/>
        <property type="gene ID" value="Ccrd_012337"/>
    </dbReference>
    <dbReference type="OMA" id="EMPRSYD"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000020">
        <property type="entry name" value="serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000028">
        <property type="entry name" value="serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="407"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="764" mass="84308" checksum="30D763CEF6F88A58" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHN2</accession>
    <name>A0A124SHN2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011552</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001030">
        <property type="protein sequence ID" value="KVI10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHN2"/>
    <dbReference type="STRING" id="59895.A0A124SHN2"/>
    <dbReference type="Gramene" id="KVI10051">
        <property type="protein sequence ID" value="KVI10051"/>
        <property type="gene ID" value="Ccrd_011552"/>
    </dbReference>
    <dbReference type="OMA" id="MKIYNAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF99">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING, PLANT-TYPE, LEUCINE-RICH REPEAT DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116655" checksum="567D39C2A20318E4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI42</accession>
    <name>A0A124SI42_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000112">
        <property type="protein sequence ID" value="KVI11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI42"/>
    <dbReference type="Gramene" id="KVI11493">
        <property type="protein sequence ID" value="KVI11493"/>
        <property type="gene ID" value="Ccrd_010095"/>
    </dbReference>
    <dbReference type="OMA" id="INWSEPE"/>
    <dbReference type="OrthoDB" id="1929779at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949:SF15">
        <property type="entry name" value="ENDOCHITINASE A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949">
        <property type="entry name" value="GASTRIC MUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="539" mass="57049" checksum="1BECE11D8263A9CA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD93</accession>
    <name>A0A103XD93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005367">
        <property type="protein sequence ID" value="KVH88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD93"/>
    <dbReference type="STRING" id="59895.A0A103XD93"/>
    <dbReference type="Gramene" id="KVH88579">
        <property type="protein sequence ID" value="KVH88579"/>
        <property type="gene ID" value="Ccrd_026433"/>
    </dbReference>
    <dbReference type="OMA" id="RQQHFDH"/>
    <dbReference type="OrthoDB" id="774437at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472:SF28">
        <property type="entry name" value="BROMO AND FHA DOMAIN-CONTAINING PROTEIN DDB_G0267958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472">
        <property type="entry name" value="OS01G0106600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="17478" checksum="98D3D75A98F076F5" modified="2016-04-13" version="1">MKQVDREIGDMISALTRRLAHLQKKPMDGANHNLHHQEEMEEEDDHRAGVGIITMAGTNEGATMRGEMMSMDQDDNYKSAGVKQDQSSPFTTYLNNNVQSVNNSIMVGGSYSANDPGIHLDVDDNYQGEPTRYGNKNKKKNKNNKETTSGSSTSDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDH5</accession>
    <name>A0A103XDH5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_025995</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:18945"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005346">
        <property type="protein sequence ID" value="KVH88715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDH5"/>
    <dbReference type="STRING" id="59895.A0A103XDH5"/>
    <dbReference type="Gramene" id="KVH88715">
        <property type="protein sequence ID" value="KVH88715"/>
        <property type="gene ID" value="Ccrd_025995"/>
    </dbReference>
    <dbReference type="OMA" id="NIRYQPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000002">
        <property type="entry name" value="Prolyl 4-hydroxylase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF240">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="171"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH88715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="33490" checksum="1035FAB50CE2C3AB" modified="2016-04-13" version="1">MRKGRSYLGRHHQGKRSSTVALVLSMLLMLTIVLLVLLALGIFSLPIGSDDGSSSYLNDHITFKRKRLLVGDGDGDGDGMGKRGDQWTEILSWEPRAFVYHNFLSKEECEYLINLAKPHMSKSTVVDSKTGQSKDSRVRTSSGTFLRRGKDKIIRNIEKRIADFTFIPVEHGEGLQVLHYEEGQKYEPHFDYFLDEFNTRNGGQRIATVLISDVEEGGETVFPAAQGNFSSRPEWNNLSECAKKGIYVKPKMGDALLFWSMRPDATLDPSSLHGGCPVIKGNKWSSTKWMHVEEYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDN6</accession>
    <name>A0A103XDN6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Crotonase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005330">
        <property type="protein sequence ID" value="KVH88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XDN6"/>
    <dbReference type="Gramene" id="KVH88830">
        <property type="protein sequence ID" value="KVH88830"/>
        <property type="gene ID" value="Ccrd_025284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010048">
        <property type="term" value="P:vernalization response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15521">
        <property type="entry name" value="PHD_VIN3_plant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000062">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase-like protein 3 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058585">
        <property type="entry name" value="Fn3_VIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032881">
        <property type="entry name" value="Oberon-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044514">
        <property type="entry name" value="VIN3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056990">
        <property type="entry name" value="VIN3-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286:SF1">
        <property type="entry name" value="VIN3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23376">
        <property type="entry name" value="Fn3_VIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07227">
        <property type="entry name" value="PHD_Oberon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23380">
        <property type="entry name" value="VIN3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="387"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1568" mass="172603" checksum="B0BC6DF5C3E579B0" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFY3</accession>
    <name>A0A103XFY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFY3"/>
    <dbReference type="STRING" id="59895.A0A103XFY3"/>
    <dbReference type="Gramene" id="KVH90045">
        <property type="protein sequence ID" value="KVH90045"/>
        <property type="gene ID" value="Ccrd_007954"/>
    </dbReference>
    <dbReference type="OMA" id="GKHDNRV"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="156"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="471" mass="51641" checksum="0F0616D394B6E7EE" modified="2016-04-13" version="1">MNNQSSSQNQNPTTPSSKISSLNYYHPSPSRTIYSDRFIPSRSASNFALFGISPPPTSDGGHGDDTSSSSSNYTALLRNALFGPDLGFVPPSTPDKKNFTIATTTPVSRNIFRFKSETRQSLHSLSPFGVDNQLPGVSHRPAKSPRIVPRSPYKVLDAPALQDDFYLNLVDWSSHNVLAVGLGNCVYLLNAFSSKVTQLCDLGVDDTVCSVGWAHQGTSLAVGTSNGKVQIWDVFHCKRVRTMEGHRSRVGALAWSSSMLSSGSRDKSVLQRDPRAQQDFVSKLNGHKSEVCGLKWSHDNRELASGGNDNRLFVWNQHSTQPVLKYCEHTAAVKAIAWSPHLYGLLASGGGTADRCIRFWNTSTNSHLNCVDTGSQVCNLVWSKNGNELVSTHGYSQNQVIVWRYPSMSKLATLTGHTYRVLYLAISPDGQTIVTGAGDETLRFWNAFPSPKSQNRESKIGASSFGRTHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH95</accession>
    <name>A0A103XH95_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH95"/>
    <dbReference type="STRING" id="59895.A0A103XH95"/>
    <dbReference type="Gramene" id="KVH90647">
        <property type="protein sequence ID" value="KVH90647"/>
        <property type="gene ID" value="Ccrd_007278"/>
    </dbReference>
    <dbReference type="OMA" id="MAGAEWR"/>
    <dbReference type="OrthoDB" id="651546at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040358">
        <property type="entry name" value="At4g22758-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055482">
        <property type="entry name" value="DUF7054"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270:SF36">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270">
        <property type="entry name" value="BNAC05G50380D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23156">
        <property type="entry name" value="DUF7054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7054" evidence="2">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="22041" checksum="3F4A3A9ABA3FDCEC" modified="2016-04-13" version="1">MSTRKSSPKRQGKNKKERLAEKSMSFHGRLAEDMVVKLIRPRTVPNLVTGRVAVTTETMPLPKLTKLLLNVTVQRSLGPVQVLISPESTVGDLIAAALRQYSKEGRRPILPSLDPSGFHLHYSQFSLESLAPEETLNELGSRNFFLCPKQASSIAGNNGGHGEIGVGYGGMTTSTPPSSSCSNEADKVTKGGAGWLRFMEFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIU7</accession>
    <name>A0A103XIU7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_006381</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004922">
        <property type="protein sequence ID" value="KVH91596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIU7"/>
    <dbReference type="STRING" id="59895.A0A103XIU7"/>
    <dbReference type="Gramene" id="KVH91596">
        <property type="protein sequence ID" value="KVH91596"/>
        <property type="gene ID" value="Ccrd_006381"/>
    </dbReference>
    <dbReference type="OMA" id="KMENWQQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05599">
        <property type="entry name" value="STKc_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000042">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000106">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000102">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="118"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="424"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH91596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="552" mass="63945" checksum="E447BC82ECC0DC1E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJN1</accession>
    <name>A0A103XJN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metallopeptidase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_006025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family. Matrix metalloproteinases (MMPs) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004897">
        <property type="protein sequence ID" value="KVH91937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJN1"/>
    <dbReference type="STRING" id="59895.A0A103XJN1"/>
    <dbReference type="Gramene" id="KVH91937">
        <property type="protein sequence ID" value="KVH91937"/>
        <property type="gene ID" value="Ccrd_006025"/>
    </dbReference>
    <dbReference type="OMA" id="ATKHFTY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000018">
        <property type="entry name" value="Metalloendoproteinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF321">
        <property type="entry name" value="METALLOENDOPROTEINASE 4-MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="13">
        <location>
            <begin position="137"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH91937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="442" mass="49610" checksum="22AFB62290BD91E3" modified="2016-04-13" version="1">MFFFLSLLHGVFPARIVPPTSPPESTVKHISGNDTWHSFAKFMDAGKGANFSGISELKNYFHRFGYIDDVNNFTDTFDETLETAVLNYQERLGLPITGELDSDTVTQIMLPRCGVSDGLNRKKHKIHVNKHYAFFSGEPRWRKPANSETMTLTYAFSNNHMIDYISYSDIRAVFLRSFSRWSSTIPVNFAEADDYRKADIKIAFYQGDHGDGEPFDGVLGVLAHAFSPENGRLHFDKAETWAVDFKSSKSNLAVDLESVATHEIGHILGLAHSSVKESIMYPSLGPRIKKVDLKIDDVEGIQALYGSNPNFRYTPSMESDISSGTRTGRGRWFKRVTSLISDLAILAMASRCNRFMNKASISNLKSAFKSASMPKSAPSSPKFPLPTRSNTSPVPRFSLSSKIDILPEHNFKELQITFTGHMNFPMPETMNWDLRDLSSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK73</accession>
    <name>A0A103XK73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_005693</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004827">
        <property type="protein sequence ID" value="KVH92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK73"/>
    <dbReference type="STRING" id="59895.A0A103XK73"/>
    <dbReference type="Gramene" id="KVH92271">
        <property type="protein sequence ID" value="KVH92271"/>
        <property type="gene ID" value="Ccrd_005693"/>
    </dbReference>
    <dbReference type="OMA" id="ISMHEIQ"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000008">
        <property type="entry name" value="Phosphatase 2C family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH92271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="385" mass="42659" checksum="BCA77BD161E8AB70" modified="2016-04-13" version="1">MLSRFINFLKACWRPSDGSDAAGRQEGLLWFKDIGQHLNGDYSMAVVQANMLLEDQSQIESGPLTFLDSGPYGTFIGVYDGHGGPETSRYVNDHLFHNLKRLASEEHSISVNVIRKAFQATEDGFMSIVAKQWTVKPQLAAVGTCCLVGVICSGTLYIANVGDSRAVLGRGVRSTGEVIAIQLSIEHNASIESIRQELHTLHPDDPQIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLRDPITRPILSSDPSISVHQIQPHDQFLIFASDGLWEHLSNQEAVDIVQNHPHNGSAKRLVKTALQEAAKKREMRYSDLKKIDRGVRRHFHDDITVVVVFLDSNLVSKASSKGPVLSLRGGGVNLSPKTLAPLSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL48</accession>
    <name>A0A103XL48_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004809">
        <property type="protein sequence ID" value="KVH92718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL48"/>
    <dbReference type="STRING" id="59895.A0A103XL48"/>
    <dbReference type="Gramene" id="KVH92718">
        <property type="protein sequence ID" value="KVH92718"/>
        <property type="gene ID" value="Ccrd_005242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15603" checksum="1A7A1149F9296A82" modified="2016-04-13" version="1">MVLVMAIGDLHIPHRAMELPAKFKSMLVPGKIQHIICTGNLCIKVVPWGDLDSLAMVQRQLDVDILVSGHTHRFMAYKHETGMVINPGSATGSYCGMTYDVNPSIVLMDIDGLRVVVYVYELIDGEVKVEKIDFKKTSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL90</accession>
    <name>A0A103XL90_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor, TCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL90"/>
    <dbReference type="STRING" id="59895.A0A103XL90"/>
    <dbReference type="Gramene" id="KVH92856">
        <property type="protein sequence ID" value="KVH92856"/>
        <property type="gene ID" value="Ccrd_005078"/>
    </dbReference>
    <dbReference type="OMA" id="CRTSWPM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017887">
        <property type="entry name" value="TF_TCP_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005333">
        <property type="entry name" value="Transcription_factor_TCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072:SF258">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03634">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51369">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="TCP" evidence="8">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="33408" checksum="C539636D0B9F01FA" modified="2016-04-13" version="1">MFWSAFEINSLYKAPYAVIKREMAILKHWLGLCCGRLGFELGEGLDSFLFPWQWLIGLGLGLGLGLGLVLGLGLDKPPSEIQIAIAKNKQQLLPPKRTSNKDRHTKVEGRGRRIRMPALCAARIFQLTRELGHKSDGETIQWLLHQAEPSIIAATGTGTIPASALASASASAPPSHGLSISMGLQHELGGGRTSWPMVGPIWPTTGFGFPSSSNSLGMENSNYNMQKIAFDLPAAGCNNLISFYNHQHEQLPPGLELGLSQDARIEVFSQEALNQMDHQARMQQQQQQQQQQQQSSKDDSQGSGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMM6</accession>
    <name>A0A103XMM6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_004421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NIPA (TC 2.A.7) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004753">
        <property type="protein sequence ID" value="KVH93530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMM6"/>
    <dbReference type="Gramene" id="KVH93530">
        <property type="protein sequence ID" value="KVH93530"/>
        <property type="gene ID" value="Ccrd_004421"/>
    </dbReference>
    <dbReference type="OMA" id="WWLGICS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF95">
        <property type="entry name" value="MAGNESIUM TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH93530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="34546" checksum="A1573FB69B607BE5" modified="2016-04-13" version="1">MTLHSWRDAYSGMSADNIKGLVLALSSSLFIGSSFIIKKKGLKKAGASGIRAGSGGYSYLYEPLWWVGMITMVVGEVANFAAYAFAPAILRLHIFGVLGCALCVVGSTTIVLHAPQERAIESVAEVWDLATEPAFVLYGVLVLVAVFVLVLHYIPLYGQTHVMCYIGVCSLVGSLSVMSVKALSIALKLTFSGTNQLVYPQTWAFTVCVLLCVITQMNYLNKALDTFNTAVVSPIYYVMFTTLTILASVIMFKDWDGQDPTQIITELCGFVTILSGTFLLHKTKDMADGSIRFSKHMDEEEGIPLRRHDSSNLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNE1</accession>
    <name>A0A103XNE1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004606">
        <property type="protein sequence ID" value="KVH93749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNE1"/>
    <dbReference type="Gramene" id="KVH93749">
        <property type="protein sequence ID" value="KVH93749"/>
        <property type="gene ID" value="Ccrd_004195"/>
    </dbReference>
    <dbReference type="OMA" id="EAYCIFK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF45">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="490" mass="56084" checksum="793B69611BFA2D59" modified="2016-04-13" version="1">MSRTPSSFNILLRRRSPKIIQSPNQQFRNSGNDGRHDDIWDKSRYSSEIVKEICGSIRSKPRWEDTLASDFPGVSLLDSSFLNQVILYQNNAFLSIRLLYWLISTYGYSPAQSTYALVFNALVEDKAVKAVKSFLDYTKFVPEPAGLESYVRCLCESGMIKDALEAFDELKKMGVCPSLETWNCILLASMKDGHTHIVWELYGEMVELGVVADVDTVGYLIQTFCIEKNVLKGYELLRQVLDDGFVPHKVAFDKLIFELVLDKKYDRVSTLLHIMIAKGVDPDLYTYQQIIHGMCIMGMHDEGLHIFNDLKDRGYAPDRIMYTTMIDGLCKVGRLGEARKLWFEMIQKGIEPNQYTYNALLNGFFKIGDMKEAQNLYEEMRVRDYAETLVTYNTMINGLCSHGRASEAFLLFKQMAQKDVPQDVITYNSLIKGFCKEGNLDKALNLLHELVQQGLQPSSASYGFLINKFYKLGQMVEVKTLWNEMHDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPD6</accession>
    <name>A0A103XPD6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_003502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPD6"/>
    <dbReference type="STRING" id="59895.A0A103XPD6"/>
    <dbReference type="Gramene" id="KVH94463">
        <property type="protein sequence ID" value="KVH94463"/>
        <property type="gene ID" value="Ccrd_003502"/>
    </dbReference>
    <dbReference type="OMA" id="HSFDHHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044785">
        <property type="entry name" value="RopGAP1-5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23177">
        <property type="entry name" value="MKIAA1688 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23177:SF35">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="119"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="46475" checksum="08032981E72E4820" modified="2016-04-13" version="1">MAGVVVVPRGTGCGGGCGGGGGRSENGTTEEASSKQHQNHISVLELLIAALRKSMAACRVDQREESKSSAIHQMEIGWPTDVQHLSHVTFDRFHGFLGLPVEFQVEIPCRVPSASVFGVSAESMQCSYDSRGNSVPTILLLMQERLYAHGGLKAEGIFRINPENSQEERVRDQLNRGMVPEGIEVHCLAGLIKAWFRELPCGVLDGLSPDEVLQCNTEDERVELVKQLKPTETALLNWAIDLMSDVAQHEESNKMNARNIAMMSDPLTALMHAVQVMNLLKTLITKTLRERKENTTNEEFNCREEIQTSCDLRRRGSSESEEDDNDEHIRYDLCGNSVDGEIEESFLKQTKENKPAKDRFKKEWDDHTVTPRSDPTSGYDFREESLVMSDGCVSGGVSRVSKESENGKNGMYELNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQC5</accession>
    <name>A0A103XQC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004480">
        <property type="protein sequence ID" value="KVH94973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQC5"/>
    <dbReference type="Gramene" id="KVH94973">
        <property type="protein sequence ID" value="KVH94973"/>
        <property type="gene ID" value="Ccrd_002959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="12683" checksum="FB5E821C587FAF55" modified="2016-04-13" version="1">MNDNDGHNFVGTVKNKQMSKIYDEFYENDVGDVRSRIATILTAGSHSNSSSLSEKSEEFWNNDIRSSNIFCLGSSSQLSSSNSSSSTSSLSQQFSRLQNSNNSKAAQFGTTAHEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRG8</accession>
    <name>A0A103XRG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004385">
        <property type="protein sequence ID" value="KVH95505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRG8"/>
    <dbReference type="Gramene" id="KVH95505">
        <property type="protein sequence ID" value="KVH95505"/>
        <property type="gene ID" value="Ccrd_002411"/>
    </dbReference>
    <dbReference type="OMA" id="RWFMAIN"/>
    <dbReference type="OrthoDB" id="1915303at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35307:SF3">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35307">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="748" mass="84791" checksum="0EFDDEB3D7DC2740" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRI2</accession>
    <name>A0A103XRI2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_002281</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRI2"/>
    <dbReference type="STRING" id="59895.A0A103XRI2"/>
    <dbReference type="Gramene" id="KVH95553">
        <property type="protein sequence ID" value="KVH95553"/>
        <property type="gene ID" value="Ccrd_002281"/>
    </dbReference>
    <dbReference type="OMA" id="QPLSWCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019199">
        <property type="term" value="F:transmembrane receptor protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000526">
        <property type="entry name" value="Kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044812">
        <property type="entry name" value="CERK1/LYK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46204">
        <property type="entry name" value="CHITIN ELICITOR RECEPTOR KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46204:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119048" evidence="14">
        <location>
            <begin position="21"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="305"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH95553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="604" mass="68201" checksum="EA0D5CE13A19B553" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT55</accession>
    <name>A0A103XT55_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="18">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_001506</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="18">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="18">Binds 2 divalent ions per subunit. The metal ions interact primarily with the substrate. Can utilize magnesium, manganese or cobalt (in vitro).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="18"/>
    <dbReference type="EMBL" id="LEKV01004316">
        <property type="protein sequence ID" value="KVH96409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT55"/>
    <dbReference type="STRING" id="59895.A0A103XT55"/>
    <dbReference type="Gramene" id="KVH96409">
        <property type="protein sequence ID" value="KVH96409"/>
        <property type="gene ID" value="Ccrd_001506"/>
    </dbReference>
    <dbReference type="OMA" id="GMITIDL"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000021">
        <property type="entry name" value="S-adenosylmethionine synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 18" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="20">
        <location>
            <begin position="68"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="21">
        <location>
            <begin position="181"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="22">
        <location>
            <begin position="304"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVH96409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="455" mass="49752" checksum="9812FC437B9823D8" modified="2016-04-13" version="1">MNLAQEEEGRSPAFTLSFYSSQGIWTILFLSSSVYGRRNRHAGTTVGGGSKILGQMFELCRFAIMETFLFTSESVNEGHPDKLCDQISDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKANVDYEKIVRDTCREIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKKPEDIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYHNDNGAMVPLRVHTILISTQHDETVTNDEIAADLKEHVIKPVVPANYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVACGLARRAIVQVSYAIGVPEPLSVFVDTYGTGKIPDREILKIVKENFDFRPGMISINLDLKRGGNGRFLKTAAYGHFGRTDPDFTWEVVKELKWEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTK6</accession>
    <name>A0A103XTK6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004264">
        <property type="protein sequence ID" value="KVH96615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTK6"/>
    <dbReference type="STRING" id="59895.A0A103XTK6"/>
    <dbReference type="Gramene" id="KVH96615">
        <property type="protein sequence ID" value="KVH96615"/>
        <property type="gene ID" value="Ccrd_001299"/>
    </dbReference>
    <dbReference type="OMA" id="WTAMIDC"/>
    <dbReference type="OrthoDB" id="1891906at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001058">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF354">
        <property type="entry name" value="REPEAT (PPR-LIKE) SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="78056" checksum="9862FC3A8D8AA855" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUG2</accession>
    <name>A0A103XUG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003862">
        <property type="protein sequence ID" value="KVH97084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUG2"/>
    <dbReference type="STRING" id="59895.A0A103XUG2"/>
    <dbReference type="Gramene" id="KVH97084">
        <property type="protein sequence ID" value="KVH97084"/>
        <property type="gene ID" value="Ccrd_000816"/>
    </dbReference>
    <dbReference type="OMA" id="REMDYSS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25669" checksum="2E5023444F1ECA7E" modified="2016-04-13" version="1">MEPTELNQIESVFGYWMKILFLLPLQQLTSFLSSASFSYHASSYTVESRARVIMFDVAGFEGSRTLQRRTSSLISHGDDNPVRSPSGDHAGLMSWPQRHIKSFQHLEHPSGNINNFSARAMQLSMYGSMVSRGSRTSPNELAKPSKKPSHSRSYPIVPPTFSRQLISVRSEGSTTVTKVGETAREPLTAPRGNTDTIDTREMDYSSDESGAEDEHIVRIDSPSTLSFPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUP9</accession>
    <name>A0A103XUP9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003849">
        <property type="protein sequence ID" value="KVH97200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUP9"/>
    <dbReference type="STRING" id="59895.A0A103XUP9"/>
    <dbReference type="Gramene" id="KVH97200">
        <property type="protein sequence ID" value="KVH97200"/>
        <property type="gene ID" value="Ccrd_000698"/>
    </dbReference>
    <dbReference type="OMA" id="HIRNTRV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH97200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="234" mass="25858" checksum="F9AC4E0FBB9408F7" modified="2016-04-13" version="1">MVVSEEATVQSMIGNGRSGVKLLQFAAEKMFTLPTSTMPNSLQTHVRNFLKKGKVNNLKKKTPKNSCVLHHISSYIAMDVTNQLKQVFKFFDIDGDGKISQLELTNVLLTFGHEKSMATMEAQGILKEVDFNGDGFIDLDEFMTIMDASNPVFAVSKQDNGGGDDDDLRNAFMVFDSDKNGLISAKELQRVLMSLGCSNSKLGQCRKMIKGVDKDGDGFVNFQEFKSMMSIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV59</accession>
    <name>A0A103XV59_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003834">
        <property type="protein sequence ID" value="KVH97381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV59"/>
    <dbReference type="STRING" id="59895.A0A103XV59"/>
    <dbReference type="Gramene" id="KVH97381">
        <property type="protein sequence ID" value="KVH97381"/>
        <property type="gene ID" value="Ccrd_000531"/>
    </dbReference>
    <dbReference type="OMA" id="GDHDNTF"/>
    <dbReference type="OrthoDB" id="696085at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF41">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="4">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH97381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="47229" checksum="F8EE4046FD959A4C" modified="2016-04-13" version="1">MAKRRWLSILKRFFIFETCQNRAKEKKRRWVLGRHKLKRITSQSAPIERPPSGPKGLPVAQVIDELKRVSDGNIQSSSSQHGDEERENGAAIKIQTAFRGFLARKALRALKGLVRLQAIIRGHLVRHQAVTTLKRLQSVINIHSQACAKRIQEVDCCPSHNCYQENKGKDSKNVHVEMNSQKRWDDSILTKEEENAMLCSKKEAALKRERIKEYAFNHRMSSESEQSKVNEKWRYWLEHWVDTQLAKREDLQNLGKKEVFESQKVKLRNLKGMDAPTYISRVTHHRKQRSIGEEHSISMVGSPVFPTYMAATESARAKSRSLSSPRLRPLSIDTWSATNSPYKHKLLSPISSINSDAGSSRVWNVNGRGGGFSQRSPSLKGVPGHVKSYKTSKHLSFNSECSMPNWDQLGHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVA9</accession>
    <name>A0A103XVA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003825">
        <property type="protein sequence ID" value="KVH97551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVA9"/>
    <dbReference type="STRING" id="59895.A0A103XVA9"/>
    <dbReference type="Gramene" id="KVH97551">
        <property type="protein sequence ID" value="KVH97551"/>
        <property type="gene ID" value="Ccrd_000324"/>
    </dbReference>
    <dbReference type="OMA" id="YHEQSAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37174">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37174:SF2">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="31239" checksum="52EC1B727522FD95" modified="2016-04-13" version="1">MMFPGVMMLTTGANVVHRSSPARTVCLASRIDADQLRDQLDQLHFEASNTRAKANKARQRLLRLSEAAEKLQQQAAISVQAGKENDAREMLLQKKKAMQALEKTKSRIEKLVGTVALNLEIEREDDASQVRVFSPPSQSLGVDGNSEKDLLNSSEGQELQDRTYNLPTEDETNNIEGSLQVPLQLSTHGIESDNDLISRLTGLTSYEDLLDRIDQYLNKVEDEVSTVVKFSTLVLESKETPANVKLQQLMEILDAVRHVRQRIAVIMESANRSRDEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVN4</accession>
    <name>A0A103XVN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVN4"/>
    <dbReference type="Gramene" id="KVH97733">
        <property type="protein sequence ID" value="KVH97733"/>
        <property type="gene ID" value="Ccrd_000132"/>
    </dbReference>
    <dbReference type="OMA" id="VCLQWSF"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="37217" checksum="6D9E9E49EDF92DD9" modified="2016-04-13" version="1">MEFHGVALRRVLELVFCITGIWSAYIYQGVLQETVSTKRFGPNKERFEHLAFLNLAQSVVCLQWSFMMIKLWGHGRGGRAPWWSYWSAGITNTIGPAMGIEALKYISYPAQVLAKSSKMIPVMLMGTLVYGIRYTFPEYLCSLLVAGGVSIFALAKTSSKTINKLANPNAPLGYGLCFLNLVFDGFTNATQDSISARYPKTNAWDMMLGMNLWGTIYNLVFMFGLPQASGYQAVQFCKQHPEAASDILYFCLCGAVGQNFIFFTISRFGSLTNTTITTTRKFVSIVVSSLLSGNPLSQKQWGSVAMVFSGLSYQIFLKRKKPKRMKKKKRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVV6</accession>
    <name>A0A103XVV6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligomerization domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVV6"/>
    <dbReference type="STRING" id="59895.A0A103XVV6"/>
    <dbReference type="Gramene" id="KVH97844">
        <property type="protein sequence ID" value="KVH97844"/>
        <property type="gene ID" value="Ccrd_000063"/>
    </dbReference>
    <dbReference type="OMA" id="VHAFDEK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="155" mass="17424" checksum="0A3946F227D3EB88" modified="2016-04-13" version="1" fragment="single">MWPSIRHRSLGFSSEAIHQWKSDLNRSFCSSIVNATNGNGKSGNVVELLNLEEVEKILRDVRADDVRVIPVKKQSEFANFVVVATGKSQWHVKQKQPGAKRMLLPSVEGQEGGNWIVIDSGSLIVHAFDEKARAYYNLEQLWTSKESSKEQSQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVW9</accession>
    <name>A0A103XVW9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVW9"/>
    <dbReference type="STRING" id="59895.A0A103XVW9"/>
    <dbReference type="Gramene" id="KVH97845">
        <property type="protein sequence ID" value="KVH97845"/>
        <property type="gene ID" value="Ccrd_000060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="14002" checksum="B3ED5E68CB3FF7BD" modified="2016-04-13" version="1" fragment="single">MFNAAVFAVKTCDRTSGCIDSQHTPCLQKKILDYFDSDDDSNIPNKMDQTSRFLRADIKVFLQSNSHAKFTPRAIARIMHGIATPAFPSSTWSRTHFWKICSLNGSPAPVVGAAADAVVVVGGDRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW68</accession>
    <name>A0A103XW68_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_023768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW68"/>
    <dbReference type="STRING" id="59895.A0A103XW68"/>
    <dbReference type="Gramene" id="KVH98013">
        <property type="protein sequence ID" value="KVH98013"/>
        <property type="gene ID" value="Ccrd_023768"/>
    </dbReference>
    <dbReference type="OMA" id="EVKKECA"/>
    <dbReference type="OrthoDB" id="618601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057425">
        <property type="entry name" value="DUF2921_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33389">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (DUF2921)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33389:SF4">
        <property type="entry name" value="PII, URIDYLYLTRANSFERASE (DUF2921)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25333">
        <property type="entry name" value="DUF2921_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119165" description="RING-type E3 ubiquitin transferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2921" evidence="13">
        <location>
            <begin position="53"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2921" evidence="13">
        <location>
            <begin position="290"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2921" evidence="13">
        <location>
            <begin position="524"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="SWEET-like" evidence="12">
        <location>
            <begin position="731"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH98013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118329" checksum="CD95C24C1016A798" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWB7</accession>
    <name>A0A103XWB7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWB7"/>
    <dbReference type="Gramene" id="KVH98076">
        <property type="protein sequence ID" value="KVH98076"/>
        <property type="gene ID" value="Ccrd_023701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706185at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119177" evidence="2">
        <location>
            <begin position="28"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="27331" checksum="A71231CD0865792A" modified="2016-04-13" version="1">MAITMNFALFFFFFFLTLSALLPPHHARHLNDGYIYVKFGRRPPRQAAPEVIQMVVGGEELLSPPSYGRDKPKAPPSPRVAPSGGQTTYSADNPKLAPPSPESAESDQGQTGYGRNNPKSPPSPKVAPSRGQTTYGGVNPKLAPSRGQTTYGGDNPKIAPPSQEIVPSFGQANYGGDNGNSNSQTTYGLEDPRTPPTPDPNDPQIQFVGRVDPKVPAPPQPAEPTRPMVKNIFPSTVAGEIEVRREFRLLFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWI0</accession>
    <name>A0A103XWI0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003808">
        <property type="protein sequence ID" value="KVH98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWI0"/>
    <dbReference type="STRING" id="59895.A0A103XWI0"/>
    <dbReference type="Gramene" id="KVH98158">
        <property type="protein sequence ID" value="KVH98158"/>
        <property type="gene ID" value="Ccrd_023628"/>
    </dbReference>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="190"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="387" mass="44686" checksum="DC5883C8A5B05EEE" modified="2016-04-13" version="1">MEDTEGTQQPHLVFANKLFLLTHSDVDDIEKVRLRDEVTSTVVADDMAPLYETLTAGSVLKLDQKVLDSMRVRIDEELKKLDDKIADAEENLGESEVREAHLAKSLFYIRIGDKEKALEQLKVTEGKTVAVGQRMDLVFYTLQMGFFYMDFDLISRSIDKAKKLFEEGGDWERKNRLKVYEGLYCMSTRNFKKAADLFLDSISTFTTYELFPYDTFIFYTVLASIISLDRVSLKQKVVDAPEILTVIGKIPYLSEFMNSLYDCQYKSFFSAFAGLTEHIKLDRYLYPHFRFYMREIRTVVYSQFLESYKSVTIEAMAKAFGVKVRGYRHKELSRFIAAGKLHCKIDKVAGVLETNRPDAKNALYQATVKQGDFLLNRIQKLSRVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWL7</accession>
    <name>A0A103XWL7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWL7"/>
    <dbReference type="STRING" id="59895.A0A103XWL7"/>
    <dbReference type="Gramene" id="KVH98218">
        <property type="protein sequence ID" value="KVH98218"/>
        <property type="gene ID" value="Ccrd_023589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF57">
        <property type="entry name" value="OS06G0474500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119164" description="Neprosin PEP catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="2">
        <location>
            <begin position="99"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="36985" checksum="F40A7334C13FB0AC" modified="2016-04-13" version="1" fragment="single">MAPKSPIIFTFVCILLSFVLLADSVPINETRFSPMEELKKVSRVRAKLKKINKPSLWAESGELCPEGTVPIRRTTKKDVLRASSLRRFGRKIRGGVRHDTMSGGHEHAVAFVNGDQYYGAKASMNVWTPTVTDPYEFSLSQLWTDAYQATGCYNLLCSGFVQTNNRIAIGAAISPRSSYNGKQFDIGIMIWKDHMEVTEILLNWTTIVDPKHGHWWLQFGSGVLIGYWPSFLFSHLQRQASMVQFGGEIVNSRSRGYHTSTQMGSGHFAGEGFGKASYFRNLQVVDWDNSLLPLTNLHLSADNPNCYDIKAGKNNVWGNYIYYGGPGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX05</accession>
    <name>A0A103XX05_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CYC/TB1, R domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003798">
        <property type="protein sequence ID" value="KVH98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX05"/>
    <dbReference type="STRING" id="59895.A0A103XX05"/>
    <dbReference type="Gramene" id="KVH98432">
        <property type="protein sequence ID" value="KVH98432"/>
        <property type="gene ID" value="Ccrd_023366"/>
    </dbReference>
    <dbReference type="OMA" id="SWSPFET"/>
    <dbReference type="OrthoDB" id="1896834at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000032">
        <property type="term" value="P:regulation of secondary shoot formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017888">
        <property type="entry name" value="CYC/TB1_R_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017887">
        <property type="entry name" value="TF_TCP_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005333">
        <property type="entry name" value="Transcription_factor_TCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072:SF226">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03634">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51370">
        <property type="entry name" value="R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51369">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TCP" evidence="8">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="R" evidence="9">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="373" mass="42228" checksum="BA64E5FE399FBFA3" modified="2016-04-13" version="1">MYPSSNSNGSRASFFGNYYNDTNHSRTPQEHYYTPSSSSSFLLPSPNYIPLEDEAVFCGLFQQQQLFTNDHNYHNTSVLAHEHSTHEMTTNVESAMGECSNNNGQVATNDRDDDPYGFNTHVEPENSSLRKRASKRDRHSKIYTARGPRDRRMRLSLDVAKKLFGLQDLLEFDKASKTVDWLLTKSKAAIQELLPDRRCSFMDVSNSASSTSECEVLSGTGDQSMVKTGDDQTTANNKAKSSSRCSKKQQEKINRIRRSANLHHPLAKATRERARERARERTIEKRYNMLVVGGQDSKFRPCLDQIMDQDANLLGSWIPFEESQHQSIVQPDQNSSQFQLKKGFVGDNSSLMMAGNWSPSYLLNYLHSTGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXJ8</accession>
    <name>A0A103XXJ8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003763">
        <property type="protein sequence ID" value="KVH98704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXJ8"/>
    <dbReference type="STRING" id="59895.A0A103XXJ8"/>
    <dbReference type="Gramene" id="KVH98704">
        <property type="protein sequence ID" value="KVH98704"/>
        <property type="gene ID" value="Ccrd_023065"/>
    </dbReference>
    <dbReference type="OMA" id="TKYHKTT"/>
    <dbReference type="OrthoDB" id="1905524at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33386">
        <property type="entry name" value="OS02G0740600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33386:SF5">
        <property type="entry name" value="OS02G0740600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9006" checksum="341256007ACA9BCF" modified="2016-04-13" version="1">MSGNGSYGTSWADQWDHNPDPSPAADYNKKTSGGGMAGKYGKKMGEGFGKTKEVAATGAKKVKQGTSVGLQWIKDKYHKTTQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY18</accession>
    <name>A0A103XY18_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein translocase SEC61 complex, gamma subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_022775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH99006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY18"/>
    <dbReference type="STRING" id="59895.A0A103XY18"/>
    <dbReference type="Gramene" id="KVH99006">
        <property type="protein sequence ID" value="KVH99006"/>
        <property type="gene ID" value="Ccrd_022775"/>
    </dbReference>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="1097767at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH99006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7697" checksum="2378B0C28D249893" modified="2016-04-13" version="1">MDAIDSVIDPLRDFAKDSARLVKRCHKPDRKEFTKVASRTAIGFVVMGFVGFFVKLIFIPINNIIVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYJ8</accession>
    <name>A0A103XYJ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003627">
        <property type="protein sequence ID" value="KVH99272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYJ8"/>
    <dbReference type="STRING" id="59895.A0A103XYJ8"/>
    <dbReference type="Gramene" id="KVH99272">
        <property type="protein sequence ID" value="KVH99272"/>
        <property type="gene ID" value="Ccrd_022497"/>
    </dbReference>
    <dbReference type="OMA" id="VECSCED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872">
        <property type="entry name" value="DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872:SF10">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="46721" checksum="BD5399EA7B64415E" modified="2016-04-13" version="1" fragment="single">MVQKRQLAEEEYDASPKHLKLENSCQLVSCLEFPSKDGPVKSCISETSESERRFESGKILDLPVCTEKDVGYSHLLRFPPLKEVPIGPEYQAVIPEWCGYDANNISFRSGSSKTSAFCQTSEANSIYDENKFMGSCIVSIHETDGTVCNDDAVGRGRTGCCCEDPDSLRCVRQHIREAREKIRRNIGHERFLELGFCSMGDVVACKWTEEDEQLFHEVVYSNPVSLGKNFWVHLAEAFPSRTNQEIVSYYFNVFVLQRRAEQNRCDPMNADSDDDEWQGSDQDENLCRDEIEKYGFSIGNPVFDYNEDMGFLHGFRGSINFSETQASMVDENGGDCDFQDDSCTSSDTGVEPEASEVKVDCGKLWSNRDFILEPLDSKAWDVGCFSFPRNKTDFLSTGSMIEEVFGVESWNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYU8</accession>
    <name>A0A103XYU8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003551">
        <property type="protein sequence ID" value="KVH99438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYU8"/>
    <dbReference type="STRING" id="59895.A0A103XYU8"/>
    <dbReference type="Gramene" id="KVH99438">
        <property type="protein sequence ID" value="KVH99438"/>
        <property type="gene ID" value="Ccrd_022328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="136"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="652"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1130" mass="130104" checksum="E675FF6CB6A58B31" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1S8</accession>
    <name>A0A103Y1S8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003162">
        <property type="protein sequence ID" value="KVI00941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1S8"/>
    <dbReference type="STRING" id="59895.A0A103Y1S8"/>
    <dbReference type="Gramene" id="KVI00941">
        <property type="protein sequence ID" value="KVI00941"/>
        <property type="gene ID" value="Ccrd_020796"/>
    </dbReference>
    <dbReference type="OMA" id="HNLVMIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF8">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="189" mass="20485" checksum="9EA2FD36D94013B3" modified="2016-04-13" version="1">MVGEVGETAEKGGSIRRWRMTTVVPLLRVLALFATAAATVAMALNKETHTFTVATIGNTPVKITLTAQMFVIANGVATLYGLVMLALSFVIHKYNLKGPWFLTVATLDMVTIAVVSGAATAVAFMGELARNGNSHARWNKICDNFQRYCNQGSGAMLASYIGIFFLMLVNMVHIFQLKRLNNLKNAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y336</accession>
    <name>A0A103Y336_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">Ccrd_020079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002906">
        <property type="protein sequence ID" value="KVI01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y336"/>
    <dbReference type="STRING" id="59895.A0A103Y336"/>
    <dbReference type="Gramene" id="KVI01643">
        <property type="protein sequence ID" value="KVI01643"/>
        <property type="gene ID" value="Ccrd_020079"/>
    </dbReference>
    <dbReference type="OMA" id="FMNMNLE"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="16066" checksum="81BA27E4A6E76A8C" modified="2016-04-13" version="1">MLPLSLLKTSQGHPMLVELKNGETYNGHLVNCDTWMNIHLREVICTSKDGDRFWRMPECYIRGNTIKYLRVPDEVIDKVQEETKNRTDRKPPGVGRGRGRGRDDGGGRRQPRGMGRGMDEGGGRGRSQGGYGGNPSNRGGGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3A3</accession>
    <name>A0A103Y3A3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002685">
        <property type="protein sequence ID" value="KVI01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3A3"/>
    <dbReference type="STRING" id="59895.A0A103Y3A3"/>
    <dbReference type="Gramene" id="KVI01754">
        <property type="protein sequence ID" value="KVI01754"/>
        <property type="gene ID" value="Ccrd_019968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="79" mass="9363" checksum="9EEF0546DF905E0A" modified="2016-04-13" version="1">MDLKLNLELKEPLTRLCNDPKTTIVVLSGSDRAVLVEHVFEYFTERTRQSHFELSETSLIRNYKYANVEFERLQARDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y569</accession>
    <name>A0A103Y569_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hly-III-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002643">
        <property type="protein sequence ID" value="KVI02722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y569"/>
    <dbReference type="STRING" id="59895.A0A103Y569"/>
    <dbReference type="Gramene" id="KVI02722">
        <property type="protein sequence ID" value="KVI02722"/>
        <property type="gene ID" value="Ccrd_018984"/>
    </dbReference>
    <dbReference type="OMA" id="AGSFYPM"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46629" checksum="8B4B92D2233E770C" modified="2016-04-13" version="1">MGKKGGVELIDNHQRIDGSLTREEGKGKKLWKKVKYQLVEYHSLPAYMKDNEFILGHYRAEWPLKQIFMSIFTLHNETLNVWTHLIGFFLFLTLTIYSAKMIPNVVDLPTLKNFPDVLRKADLHQLREDLLTCIPSLPNMPDLHKLRSDIKTTFPASSDLLPLSNWHIVELLTNCLPERFSHSNHTDVCVLRSMKEDVANIIAPLMIRPITRWPFFAFLGGAMFCLLASAACHLLCCHSKRLSYIMLRLDYAGIAALISTSFYPPVYYSFMCHPFFCNLYLGFITVLGIATILVSLLPVFDQPEYRNIRTGLFLGMGLSGAGPIFHKLILFWHQPEAVHTTGYEILMGTFYGIGSLIYATRIPERWMPGKFDIAGHSHNLFHVLVVAGAYTHYRAGLVYLKWRDIEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5A1</accession>
    <name>A0A103Y5A1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002630">
        <property type="protein sequence ID" value="KVI02789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5A1"/>
    <dbReference type="STRING" id="59895.A0A103Y5A1"/>
    <dbReference type="Gramene" id="KVI02789">
        <property type="protein sequence ID" value="KVI02789"/>
        <property type="gene ID" value="Ccrd_018921"/>
    </dbReference>
    <dbReference type="OMA" id="THCSTVA"/>
    <dbReference type="OrthoDB" id="785441at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34542">
        <property type="entry name" value="OS08G0359900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34542:SF1">
        <property type="entry name" value="OS08G0359900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="152" mass="16890" checksum="61FA39E4A06464C6" modified="2016-04-13" version="1">MATLQKFKLLATQCAVAGSPTRSPSTSPVIHLRRRKTLRMLLSRGGGGGRRMPPRDEFLDRRSSDVDSSESRKNGSVRRKLKDLLVSSPSPPPPRLLEENDCDGGEESNRWSPGGGLIIRRGGFRGLRPLSGTLRQRLLRRAWRPVLVSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5R6</accession>
    <name>A0A103Y5R6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ccc1 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:28487"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002594">
        <property type="protein sequence ID" value="KVI03020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5R6"/>
    <dbReference type="STRING" id="59895.A0A103Y5R6"/>
    <dbReference type="Gramene" id="KVI03020">
        <property type="protein sequence ID" value="KVI03020"/>
        <property type="gene ID" value="Ccrd_018686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47247" checksum="38139315A1E1D89E" modified="2016-04-13" version="1">MPMQTLSICNSHPPIHGRSLNQNLPWNPSLVTLSGFPKSLKTYSIFTLRNHPKMNNSRLTVFAVKGEEEQSTPSWAKPDSEEPPPWARNETQQASSSSNSELPFFVYLLASAITAIAAIGSVFEYVNQKPVFGVLNSDSIFYAPVLGFFAFTGLPTAVSLCSHSFGSNLLKLRIRRQRSKTEEMVIDCGEHTLPVTGVVKKKVSRGEQLQRAQWLRAAILGANDGLLSTTSLMMGVGAAQEDQWFMILSGIAGAVAGACSMAVGEFVSVATQRDIELAVNQEYLSKENSNLQEIKLEIPKNDKTIVETYIPAVPSPGRSPVLKVVLMDAREKTKKDEKEGLPNPFKAGAASALAFLCGSLFPLVSAMAVKDYTARIVAVAVVTSVALVLFGGIGAFVGGSSVRASAARVLVGGWISMAVTYSLLKPLDSVTDKNMSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y669</accession>
    <name>A0A103Y669_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002396">
        <property type="protein sequence ID" value="KVI03248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y669"/>
    <dbReference type="STRING" id="59895.A0A103Y669"/>
    <dbReference type="Gramene" id="KVI03248">
        <property type="protein sequence ID" value="KVI03248"/>
        <property type="gene ID" value="Ccrd_018457"/>
    </dbReference>
    <dbReference type="OMA" id="VAKERCC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31016:SF20">
        <property type="entry name" value="HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31016">
        <property type="entry name" value="OS04G0228100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="28059" checksum="9F180C881E360DC4" modified="2016-04-13" version="1">MRSTNEAGGFWGVLARKAKSILDDRQSPTSSLKPIVTTFSTSNHHGIQYEAYSKKIDDSPTSGNGMHTSLTSFSLNQIGDTIGNALEEAAKKSEDRIQETSAAGNSKRSALNDEEKDYAEPIQESTQLKASRHVAIATADKAKQLARELKSVKADLAVAKERCCQLEEENKILREKGPTDDDMIRDQLETLLAEKGVLAHENSVYARENRYLREIVEFHHLSMQDHMLMYLDQDDDNLLSSFHQIHPVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y687</accession>
    <name>A0A103Y687_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002389">
        <property type="protein sequence ID" value="KVI03267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y687"/>
    <dbReference type="Gramene" id="KVI03267">
        <property type="protein sequence ID" value="KVI03267"/>
        <property type="gene ID" value="Ccrd_018435"/>
    </dbReference>
    <dbReference type="OMA" id="THNDIFE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF58">
        <property type="entry name" value="VACUOLAR CATION_PROTON EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="95"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="251"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="42327" checksum="E25E306CA7A6CFC8" modified="2016-04-13" version="1">MASSATQPWLLENGTVKRLTKDSRRHGHGRSVHNMSSSSLRKKSDMSLVSKVPFSILRNFLTNLQEVILGTKLSLLFIAIPIAIAAHHFQFSRPWIFSTSLIGLIPLAERVSFLTEQIAFYTGGTVGGLLNATCGNATELIIAIFALIQHKVDVKQADVNISLLLLALLCNVMPLLYKHATTIDDALITAKVTLNLSRACSIVMLLAYFAYLAFQLWTHSHIFEAQEVQEEDEDDLHESEVESPQIGFWSALIWLIGMTAIIALLSEYLVNTIEAASSSWGMPLSFISIILLPIVGNAAEHAGAVIFAFKNKLVPVTVLVAWIIGINLDLDFNLVETGSFSLTILVTAFALQEDESKCLKMRMSICYSLNGLNEGLFWFRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8U7</accession>
    <name>A0A103Y8U7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001948">
        <property type="protein sequence ID" value="KVI04647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8U7"/>
    <dbReference type="Gramene" id="KVI04647">
        <property type="protein sequence ID" value="KVI04647"/>
        <property type="gene ID" value="Ccrd_017035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="16061" checksum="BDA28986B0ED2E2D" modified="2016-04-13" version="1">MHESCSANLVQHRLDGGGGDDTGGMKGGGVDEGGNEGGGDEVGGDEGGGDVVGGDEGGGDVVGGDEGGGDVVGGDEGGGDDFGGDGRFNSNGNGNWNNGKHDCRSDTMQVVAVVTSDPANIITKTAAHTAMYLVGLIFHQLRRMQREILMVWEELHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y952</accession>
    <name>A0A103Y952_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001907">
        <property type="protein sequence ID" value="KVI04806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y952"/>
    <dbReference type="STRING" id="59895.A0A103Y952"/>
    <dbReference type="Gramene" id="KVI04806">
        <property type="protein sequence ID" value="KVI04806"/>
        <property type="gene ID" value="Ccrd_016874"/>
    </dbReference>
    <dbReference type="OMA" id="DATHKFX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF1032">
        <property type="entry name" value="METHYLESTERASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23228" checksum="07802D1EC5122DC8" modified="2016-04-13" version="1">MEEEKKETPLKAPPHFVLIHGISGGSWCWYKMKSLMYNSGYMVTCIDLKVYVAATMLKNGFLTEQDVKDGAPDLSEYGDAYDLEFGLGSTQPPTTGTVKKELQRKLLYHMSPPEDYMLASMLLRPGPIYAIQSAQFPEGNEDVEKVPRVYIKTMYDRVIKPEQQDNMIAKWTPSQVYVLESDHSPNFSSPFALFGLLVKIAASIGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAN7</accession>
    <name>A0A103YAN7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAN7"/>
    <dbReference type="STRING" id="59895.A0A103YAN7"/>
    <dbReference type="Gramene" id="KVI05592">
        <property type="protein sequence ID" value="KVI05592"/>
        <property type="gene ID" value="Ccrd_016084"/>
    </dbReference>
    <dbReference type="OMA" id="YAFNDVH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05804">
        <property type="entry name" value="StaR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="469" mass="53324" checksum="BFE3C41564D80203" modified="2016-04-13" version="1">MGKQGIKMEDKWGYEVNTSSSSCISSINSYYHQVLSYGRRRDVIMEAIDHDPNCVLANILAAHFCCSSNPSRAPSLLHAAKSNLDSATPYEIAVLETIDCLISPNRDDDVAFELHSKLLNDFPKDLVSLKRGQVLCFYMGRPDLSLQLIEQVLLANNQENFVYGMLAFPLLELGRMEDAEKAAKKGFEINKEDPWSQHALCHVFQYECRFKEAVEFMTECSKSWDPLSSFMNTHNWWHVALCSLEGNAPLDKVYLNAVGLLLRVHVRGKIRFFEDHLKILAGYLSDRAFWYLEWHLDLLILWALACTEKSSEAQDLLDGLKSKVSKMNPKKGKLMQKGLKLAEAAFEYGRGDFTRALELLGPDFDADNCKVLRNSFFQELFASIPLYDCILQMVGASGEQLDVFNEFWFVMLLDTGRADKAIEVIERQLKKRDGTPFLWRLLERAYSMLGKQEAEAIGAKAKALEGAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB21</accession>
    <name>A0A103YB21_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB21"/>
    <dbReference type="STRING" id="59895.A0A103YB21"/>
    <dbReference type="Gramene" id="KVI05801">
        <property type="protein sequence ID" value="KVI05801"/>
        <property type="gene ID" value="Ccrd_015863"/>
    </dbReference>
    <dbReference type="OMA" id="IKPRYWV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000015">
        <property type="entry name" value="Mitochondrial transcription termination factor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="602" mass="68895" checksum="0FEB9295135F3DD7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBL1</accession>
    <name>A0A103YBL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPI biosynthesis protein Pig-F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001851">
        <property type="protein sequence ID" value="KVI06094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBL1"/>
    <dbReference type="STRING" id="59895.A0A103YBL1"/>
    <dbReference type="Gramene" id="KVI06094">
        <property type="protein sequence ID" value="KVI06094"/>
        <property type="gene ID" value="Ccrd_015564"/>
    </dbReference>
    <dbReference type="OMA" id="CSWSKAV"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="186" mass="20503" checksum="EF54B197C77426E6" modified="2016-04-13" version="1">MKNKKKGHNIKDITRGDAVLIEVPVVVLLYSLFRKDMNQSSYLKAVARGLLGLPVGAVVHALGAIVLGAPVGTQYFLRTLNWSLLMSTFTFVPAASVYGSSWVDWHRIFAQTKPIGSIDYMICLPAHGAVIGGWFGAWPMPLDWERTWQEWPICVTYGAIIGYLVGMLASFCSAVFRVSSQHVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBT6</accession>
    <name>A0A103YBT6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001845">
        <property type="protein sequence ID" value="KVI06203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBT6"/>
    <dbReference type="Gramene" id="KVI06203">
        <property type="protein sequence ID" value="KVI06203"/>
        <property type="gene ID" value="Ccrd_015487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="105" mass="11586" checksum="D69EB0B981D0446A" modified="2016-04-13" version="1">MKLDLGETYKAVVVDGKNVLLLGDEKAKAATSGDPIDVITVIELVVESLRHSDGLGGISILNDDQMVRLEKGSPLLQKVKVPDGRDDDVQFIGQWWYDGGRRDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD17</accession>
    <name>A0A103YD17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate-induced protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_014795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EXORDIUM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001567">
        <property type="protein sequence ID" value="KVI06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD17"/>
    <dbReference type="STRING" id="59895.A0A103YD17"/>
    <dbReference type="Gramene" id="KVI06847">
        <property type="protein sequence ID" value="KVI06847"/>
        <property type="gene ID" value="Ccrd_014795"/>
    </dbReference>
    <dbReference type="OMA" id="FHANIFP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF77">
        <property type="entry name" value="PHOSPHATE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="29119" checksum="4DB601198F49F4DF" modified="2016-04-13" version="1">MNLTPPTLLTYHKGSLLHGNITVNLLWYGNFSPAQKTVILDFLKSLNTRLPPPPSAASWWQTTTRYKGGLRTIHVGKQIVDKKCSLGKSLKESHLISLASKSKGFNVISVVLTAADVAVAGFCMNRCGTHGSTRVNKGHNFAYAWVGNSATQCPGQCAWPFAQPMYGPKLPSLVAPNGDIGVDGMVINLATVLAGTVTNPFDGGYFQGPATAPLEAVTACTGIFGSGAFPGYPGTVLTDKKTKASYNAQGVKQRKYLLPAMWDPKTSKCKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD18</accession>
    <name>A0A103YD18_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate-induced protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EXORDIUM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001566">
        <property type="protein sequence ID" value="KVI06850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD18"/>
    <dbReference type="STRING" id="59895.A0A103YD18"/>
    <dbReference type="Gramene" id="KVI06850">
        <property type="protein sequence ID" value="KVI06850"/>
        <property type="gene ID" value="Ccrd_014793"/>
    </dbReference>
    <dbReference type="OMA" id="RCGTHGY"/>
    <dbReference type="OrthoDB" id="2017091at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF54">
        <property type="entry name" value="PROTEIN EXORDIUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119611" evidence="6">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI06850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="32446" checksum="1BEC2A1423C1EB2A" modified="2016-04-13" version="1">MASTRLLQPHLLFLLLCVFNVSFAARRLSDTLLQYHNGALLTGDISVNLIWYGNFKPSQKTIITDFITSLSSSTSHSQSQMEPSVATWWKKTDKYFSKSAKKPTLRIGKQVSDVDCSLGKSLTEKHLVQLAAKGEPSNAVNIVLTAKDVAVDGFCSSRCGTHGSSRSKNSKFAYIWVGNSESECPGQCAWPFHQPIYGPQVAPLVAPNNDVGVDGMVINLASLMAGTATNPFGKGYYQGDAGAPLEAGSACPGVYGKGAYPGYAGELLVEESTGASYNAHGTNGRKYLLPALFDPSTSSCSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDB9</accession>
    <name>A0A103YDB9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ran GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001534">
        <property type="protein sequence ID" value="KVI06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDB9"/>
    <dbReference type="STRING" id="59895.A0A103YDB9"/>
    <dbReference type="Gramene" id="KVI06998">
        <property type="protein sequence ID" value="KVI06998"/>
        <property type="gene ID" value="Ccrd_014659"/>
    </dbReference>
    <dbReference type="OMA" id="IYQIMSR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23946" checksum="9D3CAEAA141564F5" modified="2016-04-13" version="1">MAYRVDHEYDYLFKIVLIGDSGVGKSNILSRFTRNEFCLESKSTIGVEFATRTLQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDITKRQSFENVLRWLRELRDHADSNIVIMLAGNKSDLNHLRAVPESDGHVLAEKEGLAFLETSALEAHNVEKAFQTILLDIYQIISRKALAAQEAAAAVPGQGTTITVTDSGNAKNKQKTCCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEF0</accession>
    <name>A0A103YEF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine-rich repeat, cysteine-containing subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014051</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YEF0"/>
    <dbReference type="Gramene" id="KVI07587">
        <property type="protein sequence ID" value="KVI07587"/>
        <property type="gene ID" value="Ccrd_014051"/>
    </dbReference>
    <dbReference type="OMA" id="AIMMENT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002340">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="85"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1649"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="325"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="853"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1659"/>
            <end position="1671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1681" mass="192023" checksum="D2BD4DC038C4BDF5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEY2</accession>
    <name>A0A103YEY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001480">
        <property type="protein sequence ID" value="KVI07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEY2"/>
    <dbReference type="STRING" id="59895.A0A103YEY2"/>
    <dbReference type="Gramene" id="KVI07856">
        <property type="protein sequence ID" value="KVI07856"/>
        <property type="gene ID" value="Ccrd_013778"/>
    </dbReference>
    <dbReference type="OMA" id="STIMHLD"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF167">
        <property type="entry name" value="GDSL ESTERASE_LIPASE LTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119651" evidence="4">
        <location>
            <begin position="31"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="40332" checksum="127B27D35831619E" modified="2016-04-13" version="1">MGMASSQSSYAIFFCLLLAVLKNGVLEAEARAFFVFGDSLVDNGNNNYLATTARADAPPYGIDYPTHRPTGRFSNGYNIPDLISQAIGEEATLPYLSPYLTGEKLLVGANFASAGVGILNDTGVQFVNIIRITLQMQYFEQYQQRVSDIIGPQETQRLVNQALTLITLGGNDFVNNYYLVPFSARSRQFALPDYVVYLISEYRKVLARLYELGLRRVLVTGTGPLGCVPAELAQRGQNGGCAPELQRAASLFNPQLQAMLDSLNSEIGSNVFIGANIRQTNIDFISDPGRYGFVTSKVACCGQGPFNGIGLCTGLSNLCPNRDIYAFWDAFHPSERANKIIVQQILSGSTDYMSPMNLSTIMALDAATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF73</accession>
    <name>A0A103YF73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Basic-leucine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_013645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001422">
        <property type="protein sequence ID" value="KVI07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF73"/>
    <dbReference type="STRING" id="59895.A0A103YF73"/>
    <dbReference type="Gramene" id="KVI07989">
        <property type="protein sequence ID" value="KVI07989"/>
        <property type="gene ID" value="Ccrd_013645"/>
    </dbReference>
    <dbReference type="OMA" id="DNFMAQF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF46">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DOG1" evidence="11">
        <location>
            <begin position="109"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36394" checksum="0EEF14BB1BA673AD" modified="2016-04-13" version="1">MAELSPRTDTSTDGDTEDKALGFHSSQSHGLVVSDASDKSRDQKTLRRLAQNREAARKSRLRKKAYVQQLESSRMKLTQLEQELQRARQQGIFISSSGEQSQSMSGNGALAFDVEYGRWLEEHNRRINELKGAVSNHAGDGELRIIVDGVVAHYEDIFRIKGDAAKADVFHVLSGMWKTPAERCFLWLGGFRSSELLKLLITQLEPLTEQQLLAIGNLQQSSQQAEDALSQGMEALQQSLAETIAGSLGSSNSSGNVASYMGQMAMAMGKLGTLEGFIRQADNLRQQTLQQMHRILTTRQSARALIAINDYSSRLRALSSLWLARPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFA3</accession>
    <name>A0A103YFA3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H3-K9 methyltransferase, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001391">
        <property type="protein sequence ID" value="KVI08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFA3"/>
    <dbReference type="STRING" id="59895.A0A103YFA3"/>
    <dbReference type="Gramene" id="KVI08020">
        <property type="protein sequence ID" value="KVI08020"/>
        <property type="gene ID" value="Ccrd_013615"/>
    </dbReference>
    <dbReference type="OMA" id="HYEYIAK"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000003">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025794">
        <property type="entry name" value="H3-K9-MeTrfase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051357">
        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF74">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE CHROMATIN REMODELING SET FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51575">
        <property type="entry name" value="SAM_MT43_SUVAR39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YDG" evidence="9">
        <location>
            <begin position="227"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="8">
        <location>
            <begin position="453"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="514"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="670" mass="75103" checksum="B40D1716898B9D8D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFZ7</accession>
    <name>A0A103YFZ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S5/S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001123">
        <property type="protein sequence ID" value="KVI08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFZ7"/>
    <dbReference type="STRING" id="59895.A0A103YFZ7"/>
    <dbReference type="Gramene" id="KVI08405">
        <property type="protein sequence ID" value="KVI08405"/>
        <property type="gene ID" value="Ccrd_013215"/>
    </dbReference>
    <dbReference type="OMA" id="QAEDAVW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23935" checksum="95564E39D602FB9E" modified="2016-04-13" version="1">MEVAAPVAEDGKSRSDVLLFNRWTYDDVQVPDLSVEDYITATASKHPIYMPHTAGRYQARRFRKAQCPVVERLTNSLMMHGRNNGKKLMAVRIVKHAMEIIHLLTDANPIQIIVDAVINSGWSYFVGINSGPREDATRIGSAGVVRRQAVDISPLRRVNQAIYLLTTGARESAFRNVKTIAECLADELINAAKGSSNSYAIKKKDEIERVAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG31</accession>
    <name>A0A103YG31_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001118">
        <property type="protein sequence ID" value="KVI08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG31"/>
    <dbReference type="Gramene" id="KVI08464">
        <property type="protein sequence ID" value="KVI08464"/>
        <property type="gene ID" value="Ccrd_013164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="222" mass="25428" checksum="956C275095A06DE2" modified="2016-04-13" version="1">MEVVTWEASEEFDVGLSPFKDVQRNCEEIGLVNDIETHVIDDTTSYTSNNEIQNDENPGQGISISPGGTNWYTPVVEEIIKPVIGSVYPSLDVEESIYQKYAETSGFEFSYDLVNNTTFKKQFFKLVWNIHLSRDEFESRWMVQTEIHRAAWTCSIKSVNSNEEAETYIIEHLDKRDEKIAEYKTISMLSSSDLSQQNLHTMDDLPSSDVVSSKNAARKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG53</accession>
    <name>A0A103YG53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001120">
        <property type="protein sequence ID" value="KVI08440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG53"/>
    <dbReference type="STRING" id="59895.A0A103YG53"/>
    <dbReference type="Gramene" id="KVI08440">
        <property type="protein sequence ID" value="KVI08440"/>
        <property type="gene ID" value="Ccrd_013182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="111" mass="12320" checksum="61BB6C90254EDED3" modified="2016-04-13" version="1">MISATGWLRPTIGTRSPSPNPKSFKLRASFIEYPLASKIMVRNLSYSTSETCLKEQFSNFGQIAEVKLVKDETTKKSKGQTQCVPENLWTTPAPAPKTSLRRIGDGRLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHX6</accession>
    <name>A0A103YHX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHX6"/>
    <dbReference type="STRING" id="59895.A0A103YHX6"/>
    <dbReference type="Gramene" id="KVI09385">
        <property type="protein sequence ID" value="KVI09385"/>
        <property type="gene ID" value="Ccrd_012219"/>
    </dbReference>
    <dbReference type="OMA" id="TCTDELR"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044517">
        <property type="entry name" value="PHOX1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46183">
        <property type="entry name" value="PROTEIN CLMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46183:SF8">
        <property type="entry name" value="PROTEIN CLMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="5">
        <location>
            <begin position="305"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="803" mass="89529" checksum="9013F82156AAA667" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLE3</accession>
    <name>A0A103YLE3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_010422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01000857">
        <property type="protein sequence ID" value="KVI11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLE3"/>
    <dbReference type="STRING" id="59895.A0A103YLE3"/>
    <dbReference type="Gramene" id="KVI11170">
        <property type="protein sequence ID" value="KVI11170"/>
        <property type="gene ID" value="Ccrd_010422"/>
    </dbReference>
    <dbReference type="OMA" id="SEMATAW"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010037">
        <property type="term" value="P:response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010118">
        <property type="term" value="P:stomatal movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000002">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF10">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE (2,3-DIPHOSPHOGLYCERATE-INDEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="14">
        <location>
            <begin position="18"/>
            <end position="395"/>
        </location>
    </feature>
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            <end position="307"/>
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            <end position="498"/>
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        </location>
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        <location>
            <position position="25"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <begin position="155"/>
            <end position="156"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="274"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="513" mass="55607" checksum="F21CE97065B6C7A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMA6</accession>
    <name>A0A103YMA6_CYNCS</name>
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        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000050">
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    <dbReference type="Gramene" id="KVI11719">
        <property type="protein sequence ID" value="KVI11719"/>
        <property type="gene ID" value="Ccrd_009881"/>
    </dbReference>
    <dbReference type="OMA" id="KYHRDLR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EMP70"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356250" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="613" mass="70976" checksum="1B37BD6338DAAA88" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRP7</accession>
    <name>A0A118JRP7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_024811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005744">
        <property type="protein sequence ID" value="KVH87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRP7"/>
    <dbReference type="STRING" id="59895.A0A118JRP7"/>
    <dbReference type="Gramene" id="KVH87879">
        <property type="protein sequence ID" value="KVH87879"/>
        <property type="gene ID" value="Ccrd_024811"/>
    </dbReference>
    <dbReference type="OMA" id="LENRMVE"/>
    <dbReference type="OrthoDB" id="1937547at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31729:SF18">
        <property type="entry name" value="COOPERATIVELY REGULATED BY ETHYLENE AND JASMONATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31729">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="11">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="18551" checksum="17891EA9600A704B" modified="2016-04-13" version="1">MEEIGGRGGGGGELDGRCNSSSCPSTAKRKNDQRPYKGIRMRKWGKWVAEIREPNKRSRIWLGSYSTPIAAARAYDTAVYHLRGPSARLNFPELLASDGGPHELSAASIRKKATEVGARVDAETSCTLMSRSGTPSELKPCWFQEKPDLNKIPKPEPESEYPDGDDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS55</accession>
    <name>A0A118JS55_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006236">
        <property type="protein sequence ID" value="KVH87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS55"/>
    <dbReference type="Gramene" id="KVH87432">
        <property type="protein sequence ID" value="KVH87432"/>
        <property type="gene ID" value="Ccrd_025330"/>
    </dbReference>
    <dbReference type="OMA" id="CCGRNKL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159618" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="10280" checksum="80E9C0E5B322B134" modified="2016-04-13" version="1">MASISKPGLALALIVIIVVSSSSYTVTTVDARSPYNRVRKLATDCDSPIQGEIPGCGGGGGSGGSSRPRPRPRPSGPTPGASRCRKGCCGRNKLGDCVCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS62</accession>
    <name>A0A118JS62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005478">
        <property type="protein sequence ID" value="KVH88257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS62"/>
    <dbReference type="STRING" id="59895.A0A118JS62"/>
    <dbReference type="Gramene" id="KVH88257">
        <property type="protein sequence ID" value="KVH88257"/>
        <property type="gene ID" value="Ccrd_024300"/>
    </dbReference>
    <dbReference type="OMA" id="SQFEWNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34564">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34564:SF3">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="164" mass="18740" checksum="3F16332F1747C697" modified="2016-04-13" version="1" fragment="single">MAFKHISGSSPSDTLTTLVLAISRQKFDKDFISPGLLSSIHKDFTLHFQRRFIVIKVGGLPMSRPLLLVSLLLLMVFTSQFEWNQHIVNEVEARPLALSQKQQYILEREESIILSQEKHIQKLKTLVQNLQEQLLACRGKDEYVNDTTGSLTEPLNGLNHQQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSU8</accession>
    <name>A0A118JSU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005221">
        <property type="protein sequence ID" value="KVH89382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSU8"/>
    <dbReference type="Gramene" id="KVH89382">
        <property type="protein sequence ID" value="KVH89382"/>
        <property type="gene ID" value="Ccrd_008628"/>
    </dbReference>
    <dbReference type="OMA" id="NTITHPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021042">
        <property type="entry name" value="Herpes_UL139_cytomegalovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37214">
        <property type="entry name" value="CYTOMEGALOVIRUS UL139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37214:SF2">
        <property type="entry name" value="CYTOMEGALOVIRUS UL139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12507">
        <property type="entry name" value="HCMV_UL139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="274" mass="32161" checksum="7DB416EAF5B6B5B0" modified="2016-04-13" version="1">MEAELKVEEDDIGGRIEVITSLDNGAFIYLQRKTRTNGGYQKPEPLSIIYSMLSHPNTITHPRSHSLRQMYVLINWNHWQAEKELQFNKSRTLALKLSGIRYIEQRCLKLDHKVSQFIISSLKSLLDRLDSVYLHQIQQFRVLKSEVENLEELEREKDKYFALKVRDVDEFRARSEIFVAQCQRRVEELRDCVNELNSSFIQLQCSAGYSNPSDLAAAEMRKSELEAAKDNLDRRLASNYRTKAQLQKQLMSFLISQKEWRKSSNIMIWKDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVB2</accession>
    <name>A0A118JVB2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVB2"/>
    <dbReference type="STRING" id="59895.A0A118JVB2"/>
    <dbReference type="Gramene" id="KVH92814">
        <property type="protein sequence ID" value="KVH92814"/>
        <property type="gene ID" value="Ccrd_005085"/>
    </dbReference>
    <dbReference type="OMA" id="MPTQRRG"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="312"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="530" mass="59734" checksum="68BFDC3035BE1EF5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWQ0</accession>
    <name>A0A118JWQ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major sperm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_002333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWQ0"/>
    <dbReference type="STRING" id="59895.A0A118JWQ0"/>
    <dbReference type="Gramene" id="KVH95621">
        <property type="protein sequence ID" value="KVH95621"/>
        <property type="gene ID" value="Ccrd_002333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF148">
        <property type="entry name" value="OS01G0936800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="5">
        <location>
            <begin position="84"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH95621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="504" mass="57866" checksum="D9E5B87DCA87D68C" modified="2016-04-13" version="1">MKPAYTQYNKTPNNHTRPSKWKFFDEISGQPDSTLALLTKWRNVTRSDSEQGQWHLTTTLDDGIWKSHTVDCSMLVAFINQFCSMKLENAVTLFVGEVKKQSTTSVHLSNISDEYVAFKVKTTSPKRFCVRPNSGIISPKSACDFSGMNYGKKYPVIDLSTMSLFLCNGFTMQGLRSPASEVECKDKFLIQSTVVDAATKEEDVTLDLFSKSSGKYVEEKKLRVILISKEDSLVEEQKNKKQDSPVEEHKNQKQDYLLEEHKNKKQDSSIEEHKHKKQDSSVEEHKHKKQDSPVEEHNHKKQDSPEHKNKKQDSPVEEHKHKKQDSPVEEHKHKHKKKGSPVEDHKNKVLEQEPSNESLRKEEKLLKRDEHVSPKHMRTEDVKEVKSALPKEEPKPSGDLDGNERNVSKNLKFNPVKVVKEDPQKKLRLCNQLKDLKLKESTLENQLKEAKSTISSLTYQNSKIIEAKEILQLELARRSKKGFSFVSVCLVSLVGVIVGYFSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWZ5</accession>
    <name>A0A118JWZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004318">
        <property type="protein sequence ID" value="KVH96399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWZ5"/>
    <dbReference type="STRING" id="59895.A0A118JWZ5"/>
    <dbReference type="Gramene" id="KVH96399">
        <property type="protein sequence ID" value="KVH96399"/>
        <property type="gene ID" value="Ccrd_001516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000007">
        <property type="entry name" value="Methyl-CpG-binding domain protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="808" mass="92435" checksum="E31F42B0A7C49FDB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX46</accession>
    <name>A0A118JX46_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Callose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004376">
        <property type="protein sequence ID" value="KVH95816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX46"/>
    <dbReference type="STRING" id="59895.A0A118JX46"/>
    <dbReference type="Gramene" id="KVH95816">
        <property type="protein sequence ID" value="KVH95816"/>
        <property type="gene ID" value="Ccrd_002108"/>
    </dbReference>
    <dbReference type="OMA" id="VAYLCEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="8698" checksum="CD97A7950C8D8B91" modified="2016-04-13" version="1">MASTSGTKDEVGPPRSLSRRMTRTSTMFDPNADGVDSELVPSSLASIAPILRVANEVEKDNDRVAYLCMFSQYSICLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYK3</accession>
    <name>A0A118JYK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003708">
        <property type="protein sequence ID" value="KVH98771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYK3"/>
    <dbReference type="STRING" id="59895.A0A118JYK3"/>
    <dbReference type="Gramene" id="KVH98771">
        <property type="protein sequence ID" value="KVH98771"/>
        <property type="gene ID" value="Ccrd_023002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="525" mass="55990" checksum="440B6C9597FCCC4D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYP1</accession>
    <name>A0A118JYP1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003833">
        <property type="protein sequence ID" value="KVH97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYP1"/>
    <dbReference type="STRING" id="59895.A0A118JYP1"/>
    <dbReference type="Gramene" id="KVH97390">
        <property type="protein sequence ID" value="KVH97390"/>
        <property type="gene ID" value="Ccrd_000495"/>
    </dbReference>
    <dbReference type="OMA" id="WAQIYHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF1">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="26060" checksum="AC12F46DFBA355B2" modified="2016-04-13" version="1">MTRVPLGIPSSLSSMKMIDRWSSSDWWEEINESRYWQDGIFFALCASYALVSAIALIQLIRIELRVPEYGWTTQKVFHLMNFVVNGVRAVVFGFHLQVFSLHPKAKNLPTDKLRIVYASVNAGVYLIQYGAIPRKDICCSCIAYGSRRLPALWRKVGSVTGICFTCFLVRCFVDVLSAFDSKASLDVLDHPVLNLIFYMLVEILPSALVLYILRKLPPKRVSAQYHPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYT6</accession>
    <name>A0A118JYT6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO complex, subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYT6"/>
    <dbReference type="STRING" id="59895.A0A118JYT6"/>
    <dbReference type="Gramene" id="KVH98332">
        <property type="protein sequence ID" value="KVH98332"/>
        <property type="gene ID" value="Ccrd_023449"/>
    </dbReference>
    <dbReference type="OMA" id="KDMECTP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="812" mass="91336" checksum="787272492CC843D2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYV4</accession>
    <name>A0A118JYV4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYV4"/>
    <dbReference type="Gramene" id="KVH99112">
        <property type="protein sequence ID" value="KVH99112"/>
        <property type="gene ID" value="Ccrd_022680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="11557" checksum="9067D41B313AEB43" modified="2016-04-13" version="1">MIIKKAPTTAATLQHPSPAKGSSSLSVKKYQDLLKDSAASPRMILQPRRKNSRREMVVPRRQRGSKEMVRRALTPPARKLTWRWFDFRPTPSRLAVMSMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ34</accession>
    <name>A0A118JZ34_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleosome assembly protein (NAP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003658">
        <property type="protein sequence ID" value="KVH98827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ34"/>
    <dbReference type="STRING" id="59895.A0A118JZ34"/>
    <dbReference type="Gramene" id="KVH98827">
        <property type="protein sequence ID" value="KVH98827"/>
        <property type="gene ID" value="Ccrd_022944"/>
    </dbReference>
    <dbReference type="OMA" id="PGKEFPN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="269" mass="31090" checksum="40044A0E700C7B14" modified="2016-04-13" version="1">MVADKGKKPKIGEKIVEENAEQIDGELVLSIEKLQEVQDELEKINEEASDKVLEVEQKYNEVRKPVYDKRSDIIKSIPDFWLTAFLSHPVLSDLLSEEDQKIFKHLTSLEVEDCKDVKLGYSISFNFSPNPYFEDTKLTKTFTFLDEGTTKITATSIKWKEGMGVPNGVAHDHHDHKKKGNKRCHEEDRLLTFIFFCWFSGTQQKDVMDEIHDEVAEIIREDLWTNPLTYFNNEADEEDGDEGDEEENGTDDSEEDDEDQEDDDEDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ79</accession>
    <name>A0A118JZ79_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003805">
        <property type="protein sequence ID" value="KVH98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ79"/>
    <dbReference type="STRING" id="59895.A0A118JZ79"/>
    <dbReference type="Gramene" id="KVH98245">
        <property type="protein sequence ID" value="KVH98245"/>
        <property type="gene ID" value="Ccrd_023523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053288">
        <property type="entry name" value="TGD_Bridge_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34201">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34201:SF1">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="17501" checksum="9751D5D799DA2EFB" modified="2016-04-13" version="1" fragment="single">MIICRYVSGRSGRIVVIFFVFCIRTLSFDYETSIRNLCCIIKFISIYREGALQIESYTPNLTIRIMSNRNDDEKGLFWKLPALYSDKLGKLGPAFGVGAGCGIGFGVGMIGGAGLGPGIPGLQIGFGFGAGCGVGIGGLIDEVVVNTKKLIKATHREVEKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZM3</accession>
    <name>A0A118JZM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZM3"/>
    <dbReference type="Gramene" id="KVH99817">
        <property type="protein sequence ID" value="KVH99817"/>
        <property type="gene ID" value="Ccrd_021937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1100.10">
        <property type="entry name" value="Transcription factor, SBP-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036893">
        <property type="entry name" value="SBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF459">
        <property type="entry name" value="IQ MOTIF, EF-HAND BINDING SITE, PROTEIN KINASE-LIKE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103612">
        <property type="entry name" value="SBT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="204" mass="22740" checksum="A1D9D9B2A0883A65" modified="2016-04-13" version="1">MRKGRRELKLGGQVYPTTEERWEDKNVKKSKITSNLAVCQVDDCRTDLSSAKDYHRRHWYLLKLEGLLEPVQVVGDTHVGDTGGYTNDGDSNYISRGGFGKVYKGEHIYSGAHVIVAVKRLDSTLGQGIPEFWKEIMMLFRYKHEHLVSLLGFSDEGGENILVYKYLTKVSTCISVAPVSPGSNVLTVNICIGAARGLVSSQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZT6</accession>
    <name>A0A118JZT6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003612">
        <property type="protein sequence ID" value="KVH99325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZT6"/>
    <dbReference type="STRING" id="59895.A0A118JZT6"/>
    <dbReference type="Gramene" id="KVH99325">
        <property type="protein sequence ID" value="KVH99325"/>
        <property type="gene ID" value="Ccrd_022447"/>
    </dbReference>
    <dbReference type="OMA" id="CALERNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24733" checksum="C8296CAF414B019D" modified="2016-04-13" version="1">MDVDPRQYENITINDNDSHNIVLSYLIHGCFKDTVESLVASTGLKVPAVQLEDMEKRKRILHFALEGNALDAIALTEHVSPDLLENNKDLLFDLLSLHFVELICSRKCTEALEFAQAKLTPFGKDFMALLAYEEPEKSPMFHLLSFEYRQHVADSLNRAILAHANMPSYSALEKLIRQATVVRQCLSEELGKAFILKRVAVFSRDLFLTQLNSLGSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ0</accession>
    <name>A0A118JZZ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003372">
        <property type="protein sequence ID" value="KVI00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ0"/>
    <dbReference type="STRING" id="59895.A0A118JZZ0"/>
    <dbReference type="Gramene" id="KVI00572">
        <property type="protein sequence ID" value="KVI00572"/>
        <property type="gene ID" value="Ccrd_021178"/>
    </dbReference>
    <dbReference type="OMA" id="NIAWELM"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="484" mass="53359" checksum="718062C8D9C218C5" modified="2016-04-13" version="1">MDNGIQTKLLRHEEEEVDGDLKVRVWNESKKIWRVALPGVISRVCAFGTIVVTQSFIGHISDIDLAGYALVQTLSVRFVNGILLGMSSATETLCGQAFGAGQHHMMGIYLQRSWIVDLFTLTVLLPIFVFGTQLYRLLGEEPSIAISGGYISLWFIPFVYNFVFSLTIQMFLQAQLKNMVIAWLSIFQFAIHIPLSWLLVYKMGFGVPGAMVALSISSWFLVIGEFIYIFGGWCPYSWKGFTVAAFKDLVPVVKLSVSSGIMVCLELWYNAVLVLLAGYMANAEVAISAFSICLNINAWEFMISLGFLGAACVRVANELGRGNAKAAKFSIKVLLGTSIAIGLFFFVLCLVFGKKLAYVFTDDEQVAETVADLSLLLSFSVLLNSIYPVLSGVAVGAGMQGIVAVINLVCFYVIGIPLGALLGYLTDLQVKGIWVGMICGIVTQTLALVYLTWRTDWDDQVKKSLERLNRFYVKSSDNPEEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ1</accession>
    <name>A0A118JZZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin 6, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ1"/>
    <dbReference type="STRING" id="59895.A0A118JZZ1"/>
    <dbReference type="Gramene" id="KVI00403">
        <property type="protein sequence ID" value="KVI00403"/>
        <property type="gene ID" value="Ccrd_021323"/>
    </dbReference>
    <dbReference type="OMA" id="XLIVEQQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21445">
        <property type="entry name" value="SNARE_NTD_AtSYP61-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000034">
        <property type="entry name" value="syntaxin-61 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="26564" checksum="00889FAF996EFC00" modified="2016-04-13" version="1" fragment="single">MSSIQDPYYIVKEDIQDLIDKLQFTFRQWENISANGEEHFHLTKELLENCDSIEWQVGELEKTISVVTRDPARFGINEVELEKRKRWTSIARTQVGNVKKVLCGKDVNGVSISRRNGAHRELMRMPNSQRLDGSQQYIAGENDDFSSSESDRQMLLIKQQDEELDEMTESVQRIGGVGLTIREELLAQDRIIDELGTETDDTANHLDFVQKRVDTVMKKAGIKGQLMMILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K016</accession>
    <name>A0A118K016_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003321">
        <property type="protein sequence ID" value="KVI00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K016"/>
    <dbReference type="STRING" id="59895.A0A118K016"/>
    <dbReference type="Gramene" id="KVI00722">
        <property type="protein sequence ID" value="KVI00722"/>
        <property type="gene ID" value="Ccrd_021026"/>
    </dbReference>
    <dbReference type="OMA" id="SGGQNLC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF3">
        <property type="entry name" value="PHOSPHODIESTERASE EPSILON-1, PUTATIVE (DUF1685)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="19833" checksum="276B6FC5228A3B38" modified="2016-04-13" version="1">MTSSATSSPYESEIEELEQSLEDTPMFWSTPKKILSKQLSMLETQRDLAWEKKRHQMLMQERRREAAIIASSELCDEDLKELKGCIELGFGFNEDKGGQSLTNTFPALDLYFAVNRLGSPTSPSSSSSSGSRFSPIRSLSSRSLEGSPSSVCREDPQQVKTKLRHWAQAVACSVMQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1G1</accession>
    <name>A0A118K1G1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1G1"/>
    <dbReference type="Gramene" id="KVI02837">
        <property type="protein sequence ID" value="KVI02837"/>
        <property type="gene ID" value="Ccrd_018877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="271" mass="28110" checksum="9D4D5E96A8687514" modified="2016-04-13" version="1">MDDPRMACKFPRDLFTATSRPSGKTPLCTYPNPPCPNRFDCENPSVAADSSLYEKWLLLNARGMFGGGTAEAERLPVVLDHGEVAHLPPAPTGVPIIPDLCNLLVGGGGDWWRAALFDEGTNARVEERGGGERGGGEEGGGERGGGEEEGGGGERGGGEEEGGGGESGGGEEEEGGGGERGGGEEEDGGGGERGGPRGGEEPKGGGRDDFGVGADRKALLIVSEREVWYLIEDGKDSTKRRDVSSASNSLGGDRRVMKPLMNDPETPTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1R4</accession>
    <name>A0A118K1R4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01002399">
        <property type="protein sequence ID" value="KVI03242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1R4"/>
    <dbReference type="Gramene" id="KVI03242">
        <property type="protein sequence ID" value="KVI03242"/>
        <property type="gene ID" value="Ccrd_018464"/>
    </dbReference>
    <dbReference type="OMA" id="NARNTCP"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF242">
        <property type="entry name" value="OS06G0633500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="39945" checksum="120B72250F442A04" modified="2016-04-13" version="1">MDMNGTITVEPWDQPRRCVLCHRILSSEIEVEATSICGDCKFLFLEDSDIQHNTRQTRYNNNSESIENMQFPDMTNLVTVSEHGNQSRRWRRVLSDTESDGFDSDVSVEVDSDMPAHPHSDDASLNQSNSDDDNEFEEVENTVGSLVGRVQLRRSLASNGRNLQVDWLNEILSPEAENLERSRYVGNAGDYLDARGFEQLLERLAETDGSRRGAPPAAVSFVKNLERVVVDEDEGLVCVICKDSVCVGSVVNRLPCLHVYHPSCIMPWLNARNTCPLCRYELPTDERECERRMRRRSRSQQVEMEEEVGEDASSGGGGRWWVVAAPLATMMAIGFVVWLGGGVNRNRRWWCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K215</accession>
    <name>A0A118K215_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_018026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K215"/>
    <dbReference type="STRING" id="59895.A0A118K215"/>
    <dbReference type="Gramene" id="KVI03677">
        <property type="protein sequence ID" value="KVI03677"/>
        <property type="gene ID" value="Ccrd_018026"/>
    </dbReference>
    <dbReference type="OMA" id="YIHANEI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="60"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI03677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="34952" checksum="9909A2B584F86126" modified="2016-04-13" version="1">MYWFKNLTRLSSPFKHHSTGKFTPPTLFSLQHLHHFTTAGDAVAPPTSGLEPTKKTDKPRVVVLGSGWAGCRLMKGIDTSLYDVVCVSPRNHMVFTPLLASTCVGTLEFRSVAEPIGRIQPAISSEPGSYFFLANCKGLDVKNHEVSYDKLVIASGAEASTFGIKGVKEHAIFLREVHHAQEIRRKLLLNLMLSDVPGVSDEEKRRLLHCVVVGGGPTGVEFSGELSDFIMRDVHQRYSHVKDYIHVTLIEANDILSSFDDRLRVYATKQLTKDVQPKKIVLSDGTDVPYGLLVWSTGVGPSTFVQKTDLPKAPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3K4</accession>
    <name>A0A118K3K4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">cinnamoyl-CoA reductase</fullName>
            <ecNumber evidence="6">1.2.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylpropanoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.44" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3K4"/>
    <dbReference type="STRING" id="59895.A0A118K3K4"/>
    <dbReference type="Gramene" id="KVI06073">
        <property type="protein sequence ID" value="KVI06073"/>
        <property type="gene ID" value="Ccrd_015577"/>
    </dbReference>
    <dbReference type="OMA" id="KPECTGQ"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016621">
        <property type="term" value="F:cinnamoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08958">
        <property type="entry name" value="FR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000199">
        <property type="entry name" value="Cinnamoyl-CoA reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF404">
        <property type="entry name" value="CINNAMOYL-COA REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="37033" checksum="799BC24FE32B9D52" modified="2016-04-13" version="1">MSPASKQVICVTGAGGFIASWMVKLLLEKGYFVRGTVRNPDDPKNVHLIELEGAKERLTLYKADLLDFESLREAINGCDGVFHTASPVTDDPEQMVEPAVIGTRNVIVAAAECKVRRVVFTSSIGAVYMDPHRGPDDVVDESCWSDLEFCKNTKNWYCYGKAVAEQAAWDEAKAREVDLVVVNPVLVLGPLLQSTVNASIIHILKYLTGSAKTYANSVQAYVHVRDVALAHILLFETPSASGRYLCAESVLHRGEVVEILAKFFPEYPIPTKCSDEIKPRAKPYKFSNQKLKDLGLEFTPVKECLYETVKSLQEKGHLPVQPTGHTDDHIRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K483</accession>
    <name>A0A118K483_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C14, caspase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001524">
        <property type="protein sequence ID" value="KVI07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K483"/>
    <dbReference type="STRING" id="59895.A0A118K483"/>
    <dbReference type="Gramene" id="KVI07080">
        <property type="protein sequence ID" value="KVI07080"/>
        <property type="gene ID" value="Ccrd_014564"/>
    </dbReference>
    <dbReference type="OMA" id="VCHAFTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF32">
        <property type="entry name" value="METACASPASE-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="35859" checksum="56992BEEC6A24D41" modified="2016-04-13" version="1">MLMLVDCSNCRTPLQLPAGARSIRCAICQAITRVAEPRNLPPPLPTQPYATSSNNHHAPSQPHRPPPVPSPYNQASSVGQTQSVNGRKKAVICGISYKRTKHELNGCINDAKCMKYLLINKFKFPESSILMLTEEESDPYRIPTKHNIRMAMFWLVQGCQPGDSLVFHFSGHGSQQRNYTGDEIDGFDETLCPLDFETQGMIVDDEINATIVKPLPHGVRLHAIIDACHSGTMSGRYVWEDHSPQSGIFKGTNGAIERGHATTYGDMLTSMRTTIRRNESDTGGGSGGAVTSLLGMLLSGGSLGGGLRQEPQLTASEPFDVYTKRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4D2</accession>
    <name>A0A118K4D2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_014281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4D2"/>
    <dbReference type="STRING" id="59895.A0A118K4D2"/>
    <dbReference type="Gramene" id="KVI07323">
        <property type="protein sequence ID" value="KVI07323"/>
        <property type="gene ID" value="Ccrd_014281"/>
    </dbReference>
    <dbReference type="OMA" id="DDCIVQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF108">
        <property type="entry name" value="OS03G0286100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159963" description="RING-type E3 ubiquitin transferase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI07323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="387" mass="43441" checksum="AB7CEC368279FF25" modified="2016-04-13" version="1">MPPPISFTHLTTLLTGLMAEHPPPPSSPPPAVSNNPDPIQYWCYQCDKRVPVETRPDHPDIICFECKNGFVESISVAAHTRQVSDEDTPAFGNEFLQVLRLIAQAAREDDEPPPPPSDHPAGDNDYLRIELDGWDNGNVNLNEDEDEDEDQEDPYQGDQDRARFVVDDDDDIDDDEHDEEEEIQNRNLEEDEEDFVRRERRDVLRLRLRDFASRAASRRNRILDWAEILMGLEDQSIEFRLQVPGDDDGYVGNPGDYVDAAGYEALLQNLAENDTSGRRGAPPAAKLAVEGLQTVELNSTNMEICAICKDRVFNNEEKIAKKLQCGHMYHGDCIVPWLGSRNTCPVCRYELPTDDPEYEEDRKKRSITVAASATDHGCSSSSGGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4E7</accession>
    <name>A0A118K4E7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_014282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4E7"/>
    <dbReference type="STRING" id="59895.A0A118K4E7"/>
    <dbReference type="Gramene" id="KVI07322">
        <property type="protein sequence ID" value="KVI07322"/>
        <property type="gene ID" value="Ccrd_014282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF81">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159951" evidence="12">
        <location>
            <begin position="26"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="621"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="706" mass="78068" checksum="3EFA5829839C1A05" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4N7</accession>
    <name>A0A118K4N7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7796 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001493">
        <property type="protein sequence ID" value="KVI07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4N7"/>
    <dbReference type="STRING" id="59895.A0A118K4N7"/>
    <dbReference type="Gramene" id="KVI07727">
        <property type="protein sequence ID" value="KVI07727"/>
        <property type="gene ID" value="Ccrd_013910"/>
    </dbReference>
    <dbReference type="OMA" id="QSRMAVC"/>
    <dbReference type="OrthoDB" id="2016723at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056698">
        <property type="entry name" value="DUF7796"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35112">
        <property type="entry name" value="OS08G0360500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35112:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25072">
        <property type="entry name" value="DUF7796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7796" evidence="1">
        <location>
            <begin position="102"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="445" mass="50198" checksum="65F219ECEC7A1329" modified="2016-04-13" version="1">MKNPQKLFLQITKRLSEIKWRFLLLLIVPISLLLFISITTTARGGDFSDYNPFYFLSNLKSLFYNDNNNSNQNRSPNYSAITFPTTDKAWPPVIGDRKSELEQSRMAVCLVGGARRFELTGPSIVEKILEEYPNADLFVNSPLDSKSYKFSLLKTAPRIAAIRIFKPEKIPENDAAVRVLTASNSPNGIQGLLQYFNLVEGCLTMVESYQKRNNFTYDWIVRTRVDGYWSTRLRPDIFIPGHYVVPSGSSYGGLNDRFGVGDFNTSVAALSRLSMIPEIDSAGFHELNSESAFQAQLRVRNISFLTKRLPFCVVSDRTYDFPPEKFGVPVAALSSKGPLSGVKCRPCTAKYSGKLATAIVNGLYRQWSWTDTGNNTLQLCDGHGRWEDGWEKLFDSTAGKKLSAVRKRVSSLSFEQCVADFEFMKRRSAVWDVPPAVDICSQFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K678</accession>
    <name>A0A118K678_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K678"/>
    <dbReference type="STRING" id="59895.A0A118K678"/>
    <dbReference type="Gramene" id="KVI10260">
        <property type="protein sequence ID" value="KVI10260"/>
        <property type="gene ID" value="Ccrd_011365"/>
    </dbReference>
    <dbReference type="OMA" id="SCKFAFG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000007">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF27">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 3, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="36781" checksum="977567030F664382" modified="2016-04-13" version="1">MATKKSVSSLKEGDLKGKRVFIRVDLNVPLDDSFKITDDTRIRAAVPTIKYLMSNGARVVLSSHLKLVAEIPNGGVLLLENVRFYPEEEKNDPEFAKKLASLGDLYVNDAFGTAHRAHASTEGVAKHLKPSVAGFLMQKELDYLVGAVSNPKKPFAAIVGGSKVSSKIGVIESLLEKVNILVLGGGMIFTFYKAQGHKVGSSLVEEDKLSLATSLLEKAKSKGVSLLLPTDVVVADKFAADANSKVVPANSIPDGWMGLDIGPDSIKSFSETLDTTKTVIWNGPMGAIAKKLADLSGKGVTTIIGGGDSVAAVEKVGLADKMSHISTGGGASLELLEGKSLPGVLALNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6D5</accession>
    <name>A0A118K6D5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001019">
        <property type="protein sequence ID" value="KVI10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6D5"/>
    <dbReference type="STRING" id="59895.A0A118K6D5"/>
    <dbReference type="Gramene" id="KVI10487">
        <property type="protein sequence ID" value="KVI10487"/>
        <property type="gene ID" value="Ccrd_011137"/>
    </dbReference>
    <dbReference type="OMA" id="EQKTMTV"/>
    <dbReference type="OrthoDB" id="786617at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36808">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36808:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="542" mass="60612" checksum="4223DD39D73B3391" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124R4Z7</accession>
    <name>A0A124R4Z7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C48, SUMO/Sentrin/Ubl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008110">
        <property type="protein sequence ID" value="KVG47221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124R4Z7"/>
    <dbReference type="Gramene" id="KVG47221">
        <property type="protein sequence ID" value="KVG47221"/>
        <property type="gene ID" value="Ccrd_026401"/>
    </dbReference>
    <dbReference type="OMA" id="QFNTHED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="649"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVG47221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="827" mass="94801" checksum="A499847890117408" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S5T8</accession>
    <name>A0A124S5T8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006541">
        <property type="protein sequence ID" value="KVH72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124S5T8"/>
    <dbReference type="STRING" id="59895.A0A124S5T8"/>
    <dbReference type="Gramene" id="KVH72802">
        <property type="protein sequence ID" value="KVH72802"/>
        <property type="gene ID" value="Ccrd_025580"/>
    </dbReference>
    <dbReference type="OMA" id="QVWNRIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="154" mass="17057" checksum="0E557EA6E3D0C549" modified="2016-04-13" version="1">MPFIFDTVWDLVKLADYLTGRDDIDHSRIGITGESLGGMHAWFAAFVDTRYSVVVPIIGVQVWNRIAPGLTSEFDSVHTVPLIAPRPLLILNGEEDPRCPIAGLDVTISRTCKAFQDANCPDSFKVIAEAGIGHEMTGSMVKEAMNWFDKFFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDI5</accession>
    <name>A0A124SDI5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003866">
        <property type="protein sequence ID" value="KVH97057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDI5"/>
    <dbReference type="STRING" id="59895.A0A124SDI5"/>
    <dbReference type="Gramene" id="KVH97057">
        <property type="protein sequence ID" value="KVH97057"/>
        <property type="gene ID" value="Ccrd_000852"/>
    </dbReference>
    <dbReference type="OMA" id="GNSIKCC"/>
    <dbReference type="OrthoDB" id="1856818at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="18943" checksum="A617A7D1F24C2F56" modified="2016-04-13" version="1">MKNTIRCCISCILPCGALDVIRIVHSNGHVEEISGSIRAAEIMKLYPKHVLKKPSSPSYTDEGTVSCPKIIIMPPDAELKRGQIYFLMPVPPSSMPEKARSKASATTRKKKNVANKNDHHNSLLTNLLVSDRYLTEILSEKVKDRRRGRVRVWRPHLESISEATSDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE71</accession>
    <name>A0A124SE71_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule-associated protein, MAP65/Ase1/PRC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003635">
        <property type="protein sequence ID" value="KVH99172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE71"/>
    <dbReference type="STRING" id="59895.A0A124SE71"/>
    <dbReference type="Gramene" id="KVH99172">
        <property type="protein sequence ID" value="KVH99172"/>
        <property type="gene ID" value="Ccrd_022607"/>
    </dbReference>
    <dbReference type="OMA" id="IPDKSHG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="484" mass="54051" checksum="715D616EC96FD505" modified="2016-04-13" version="1">MAEVDVQNPLIGETTCGTLLHQLQKIWDEVGESDEERDKMLLQLEQDCLDVYKRKVDQAAKSRAHLLQTLADAKLELSTLLASLGEKTFLGIPEKTSGTIKEQLAAIAPALEQLWKQKEERIKEFLDVQTQIQKICGEIAGSNQQAGSPTVDESDLSLKKLDEFHDQLQELQKEKSKSISNGTLARLAKTVLALKEDKKQRLKKLQELATQLIDLWNLMDTSEEERSLFDHVTCNISASVDEAEVEAERLDKLKASRMKEIALKRQGELEEIFVRAHIEIDTQAAREKILALIDSGNVEPSELLVDMDNQIIKAKEEAISRKDILDKDDNRYNASRGAHLNLKRAEKARILVNKIPAWEEEHGVTFAYDGVPLLAMLDEYALLRHDREEEKRRMRLNTEQEAIFGSRPSPARPLSSAKKVVGPRVNGGAANGTPNRRLSLNQNGGRSGKRDSGARPIAPLNYVAISKEDAASHVSGTEPSPNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE92</accession>
    <name>A0A124SE92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003574">
        <property type="protein sequence ID" value="KVH99386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH99386">
        <property type="protein sequence ID" value="KVH99386"/>
        <property type="gene ID" value="Ccrd_022383"/>
    </dbReference>
    <dbReference type="OMA" id="XCISRDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="8975" checksum="0E7CCE233E178A68" modified="2016-04-13" version="1">MTIAEFTNYLAQFDTNHDXCISRDELCQAIRKNGGWFASWKASHGVNSVDTNGNGLIDENEIPKLAAFAEKELNIKIITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFZ5</accession>
    <name>A0A124SFZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001910">
        <property type="protein sequence ID" value="KVI04788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFZ5"/>
    <dbReference type="Gramene" id="KVI04788">
        <property type="protein sequence ID" value="KVI04788"/>
        <property type="gene ID" value="Ccrd_016887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="114" mass="13211" checksum="782AB68A8AC45F5E" modified="2016-04-13" version="1">MEADYSLEHKSYGDLRMFPDHEQSLEDFANKFEVIEVVVVIWNGPSTHGIISRNRNCCQRGSCIFEIFERQSLEVGWIRKYVATFRDQGVVFPIFELQSKWIVLALSGKILLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG57</accession>
    <name>A0A124SG57_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001877">
        <property type="protein sequence ID" value="KVI05341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG57"/>
    <dbReference type="STRING" id="59895.A0A124SG57"/>
    <dbReference type="Gramene" id="KVI05341">
        <property type="protein sequence ID" value="KVI05341"/>
        <property type="gene ID" value="Ccrd_016325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF52">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="492" mass="55462" checksum="D4EC7C8A052792B8" modified="2016-04-13" version="1">MAQLPSANQVNLLKDIFTRFDLDSDGSLTQLELAALFRSVGLIPVGDEFDAVLAKMDANGNGSIEFEELLNAILPDFDEEVFVNQDQLMKVFQLFDKDGDGSITPAELAGQMAKMGLPLTYRELNDLMNDIDTNGDGIIIYAIRLLYNNHNTTTLLMRPSSSRRLSLQVQVIQVVVSCYRPSREPDRRCPYRPLSHHVNILWIIGVTFVSDPLYHSMAVVERFTGIAPYAKRKMYQRTIPPQMKMCWIKRKKMITPLASPLSIQPNIRRHLKRIQRLEGRLGIRHTLRQNRADTSWSKTPNAMAGSDVKNTLTTANNGRTANSEIQKRVLNVIVQSVCQRFSIDDQSIWIRRRSIKLSLPCYYLLLDANSKPSSLAAITKAASSGDSASYVTFPVSSSTSDGTQKSNQKQDQEQEIDNAIHSPLDSTSFRRRPPHSSMTAREDQPGRIRPFLPSLRHLLLMRNPSEKQETGALHTSQSNKLNGFKQKSPKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGM7</accession>
    <name>A0A124SGM7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_014786</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001562">
        <property type="protein sequence ID" value="KVI06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGM7"/>
    <dbReference type="STRING" id="59895.A0A124SGM7"/>
    <dbReference type="Gramene" id="KVI06858">
        <property type="protein sequence ID" value="KVI06858"/>
        <property type="gene ID" value="Ccrd_014786"/>
    </dbReference>
    <dbReference type="OMA" id="QYRVPDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000305">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000330">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="51"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="472" mass="53147" checksum="7251DEFB6415BCFC" modified="2016-04-13" version="1">MLVMVGDEMDKDFDSKLSIQNNSDNHVDANANRSKGFVFRAPQENFTIHDFELGKIYGVGSYSKVVRARKKDTGKVYALKIMDKNFITKENKIAYVKLERIVLDQLDHPGIVQLFFTFQDTTSLYMALESCEGGELFDQITRKGRLTEDEARFYAAEIVDALEYIHNLGLIHRDIKPENLLLTSDGHIKIADFGSVKPMQDSRITVLPNAASDDKACTFVGTAAYVPPEILNSSPATIGNDLWALGCTLFQMLSGTSPFKDASEWLIFQRIVARDIRFPDYFSDEARDLIDKLLDIDLAKRPGAGCEGYASLKNHPFFQTIDWHDLRSRSPPRPALQGHSSGGEDTHDSSFNPSNVGDATSFSEASNVTRLASMDSFDSKWQQFLEPGETILMISMVKKLQKLTSKKVQLILTNKPKLIYVDPAKLVTKGNIIWSDNPNDLSIQPKKVMSFEDPKQRAFQWKKAIEALQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGP8</accession>
    <name>A0A124SGP8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001524">
        <property type="protein sequence ID" value="KVI07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGP8"/>
    <dbReference type="STRING" id="59895.A0A124SGP8"/>
    <dbReference type="Gramene" id="KVI07093">
        <property type="protein sequence ID" value="KVI07093"/>
        <property type="gene ID" value="Ccrd_014542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="16709" checksum="2D16314ECFB3708C" modified="2016-04-13" version="1" fragment="single">GLKNSRRRAFSIWRSGFLQIPKSNQIYVKFPISISMALSNLHRLLSTPPTAISRSTIIFSAFRSEFTNSTNRFISSVTENLQTHQDHDGATNEEDKVQKAQGHEEENDEDDGEELDINKETGEYGGPRGPEPTRYGDWERNGRCSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGR5</accession>
    <name>A0A124SGR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_014398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001509">
        <property type="protein sequence ID" value="KVI07228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGR5"/>
    <dbReference type="STRING" id="59895.A0A124SGR5"/>
    <dbReference type="Gramene" id="KVI07228">
        <property type="protein sequence ID" value="KVI07228"/>
        <property type="gene ID" value="Ccrd_014398"/>
    </dbReference>
    <dbReference type="OMA" id="EWADDEC"/>
    <dbReference type="OrthoDB" id="1929298at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000002">
        <property type="entry name" value="Nac domain-containing protein 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF216">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="NAC" evidence="12">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI07228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="524" mass="58343" checksum="3434BBF69BE72AFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103IM63</accession>
    <name>A0A103IM63_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009759">
        <property type="protein sequence ID" value="KVF16800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103IM63"/>
    <dbReference type="Gramene" id="KVF16800">
        <property type="protein sequence ID" value="KVF16800"/>
        <property type="gene ID" value="Ccrd_026851"/>
    </dbReference>
    <dbReference type="OMA" id="WLEWINK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF15">
        <property type="entry name" value="CYTOCHROME P450 71A2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVF16800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="914" mass="103724" checksum="34EC9F41A44264BB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XAY8</accession>
    <name>A0A103XAY8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_025393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006300">
        <property type="protein sequence ID" value="KVH87376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XAY8"/>
    <dbReference type="Gramene" id="KVH87376">
        <property type="protein sequence ID" value="KVH87376"/>
        <property type="gene ID" value="Ccrd_025393"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000047">
        <property type="entry name" value="Myb transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000394">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051953">
        <property type="entry name" value="Plant_SW-associated_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47997">
        <property type="entry name" value="MYB DOMAIN PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47997:SF75">
        <property type="entry name" value="MYB DOMAIN PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH87376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="345" mass="39857" checksum="E1D2E2887A24692F" modified="2016-04-13" version="1">MGRHSSCYKQRLRKGLWSPEEDEKLINHITKFGHGCWSSIPKLAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNKWSQIAAQLPGRTDNEIKNLWNSSIKKKLRQKGIDHNTHKPISDFENDENDHRNTADKPKPLMVLPAPETHEFFLTRYGTSDRTAATDTRHLNSDHFPGFIDFNYGQPLPESTIFFGSNLSSDSNSDSLPAELIPEYTTAIPSSVGSGFHRNNWELSSLFETNNGVSWGLTNSYFGRNQKELHSQIPFPTQQQEMKWNRHLQYPFLLGSCTIQSRELYDETKPETDLGMKRELFQNHQSEDTYNKQLHRMSASYEQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB61</accession>
    <name>A0A103XB61_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006156">
        <property type="protein sequence ID" value="KVH87478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB61"/>
    <dbReference type="STRING" id="59895.A0A103XB61"/>
    <dbReference type="Gramene" id="KVH87478">
        <property type="protein sequence ID" value="KVH87478"/>
        <property type="gene ID" value="Ccrd_025264"/>
    </dbReference>
    <dbReference type="OMA" id="MIFTEEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF475">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING DOMAIN, PGG DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="2">
        <location>
            <begin position="298"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="485" mass="55071" checksum="F465BD5E987AF761" modified="2016-04-13" version="1">MYTTSQPILARNLEMGDSSNGERNKSLEMADSGARIEDLKYLYASNVNVSNFVSEKLSGHRKYHVWKAQMVCLMETQKMHGIVDPKFVGPEAQDADIVKQYDNLLRVPAAMFYPIYQLICLFILVLLYPFIVLYFLLWKVLATVVAPIKLVEKKKKDYKEAKEILKLVCDHIDRLGFSGSHHPCYSRPILEAACQGAYEVVDEILFRFPKAIDCKNQNGLNIIQLAVINRSEKVYNLIYHIVERKDFYRTVMDSSKNNILHLAGRLSPSPYITEENIFKETPEMVFTREHEKLVKEGEKWMKSTAESCSITAALITTIVFAAAITVPGGSNQETGIPMFKGTIPFTIFAVSDAISLFASTTALLVFLSILTARFSEQDFLVSLPRRLIIGLCTLFLSTTMMMIAFSATLFLVFVDQRNWMLAPIGGLTCLPIAVFVTLQFPLVVDLFRSTYFPIFGKQSYIERGKFNPNNIQYFFGNRGIEYVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB66</accession>
    <name>A0A103XB66_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006131">
        <property type="protein sequence ID" value="KVH87501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB66"/>
    <dbReference type="SMR" id="A0A103XB66"/>
    <dbReference type="STRING" id="59895.A0A103XB66"/>
    <dbReference type="Gramene" id="KVH87501">
        <property type="protein sequence ID" value="KVH87501"/>
        <property type="gene ID" value="Ccrd_025239"/>
    </dbReference>
    <dbReference type="OMA" id="VGMAPFM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000017">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="12">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH87501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="685" mass="74520" checksum="2A35A5C02FB9E51C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCF0</accession>
    <name>A0A103XCF0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_024516</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May interact with bacterial adhesins thereby protecting the reproductive tissues from microbial attack. Has no oxalate oxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. In the absence of manganese, it forms tetrameric and pentameric forms which show superoxide dismutase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Secreted</location>
            <location evidence="1 15">Extracellular space</location>
            <location evidence="1 15">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005578">
        <property type="protein sequence ID" value="KVH88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCF0"/>
    <dbReference type="STRING" id="59895.A0A103XCF0"/>
    <dbReference type="Gramene" id="KVH88098">
        <property type="protein sequence ID" value="KVH88098"/>
        <property type="gene ID" value="Ccrd_024516"/>
    </dbReference>
    <dbReference type="OMA" id="CVADISH"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000025">
        <property type="entry name" value="germin-like protein subfamily 2 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019615236" description="Germin-like protein" evidence="15">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="16">
        <location>
            <begin position="58"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="22874" checksum="79B1965675D8C2F6" modified="2016-04-13" version="1">MANSDYGLVIGMMMAFFLASFVSADPELLQDVCVADLASGVKLNGFTCKSNISADDFFFAGLAKPALTNNTFGATVTPASVQQITGLNTLGVSMARIDYAPGGLNPPHTHPRATEIVFVLEGELDVGFITTDNKLFSKTIKTGEIFTFPRGLLHFQMNKGKVPAAVIAGFNSQLPGTQRAANALFASSPTVEDAVLTKTFQVGTKEVEKIKSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDT4</accession>
    <name>A0A103XDT4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005326">
        <property type="protein sequence ID" value="KVH88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDT4"/>
    <dbReference type="STRING" id="59895.A0A103XDT4"/>
    <dbReference type="Gramene" id="KVH88913">
        <property type="protein sequence ID" value="KVH88913"/>
        <property type="gene ID" value="Ccrd_024734"/>
    </dbReference>
    <dbReference type="OMA" id="GRWEYPY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="163"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="48262" checksum="18B562B3B1CEA9BD" modified="2016-04-13" version="1">MESIIPTWQVSFLCGILTWIVVSSMFNVTQKIRSSIQPWVSRHVISGTPAILQIQKYQRGSLDAFFSGLSCVVSVPFYTGFLPLLFWVNSLFLYVETSLAEPIIKRVISIWSKFIGNSFQNNQPSCEIAKRKNTIFCRFEFLFVNFVIFAFFCWDLSGHGKLARQMTLLMAFCDYSGNCIKDVVSAPRPKSPPVRILTATKDEKENALEYGLPSSHTLNTVCLSGYLLHYVFSCLENTDASYRVASFLFVCLLVGLIGFGRIYLGMHSVIDIIGGLVLGLTILAFWLHLHESIDNFVTGVQQTYHQFHHEKVARVFTPELTIPAFAGRVLVGIPTILLVKFCSKALAKWILPITASALGIPVRSSGYVTALTVSPAVKRSNEVKQTSGYLQKMFFGSQDSFDVDTGIRLLQYAGLAWSVVDLVPSLFSHLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEC6</accession>
    <name>A0A103XEC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005303">
        <property type="protein sequence ID" value="KVH89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEC6"/>
    <dbReference type="STRING" id="59895.A0A103XEC6"/>
    <dbReference type="Gramene" id="KVH89180">
        <property type="protein sequence ID" value="KVH89180"/>
        <property type="gene ID" value="Ccrd_008836"/>
    </dbReference>
    <dbReference type="OMA" id="MIYASIF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118717" evidence="3">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="630" mass="71147" checksum="BEE77754401ACEAB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF10</accession>
    <name>A0A103XF10_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005199">
        <property type="protein sequence ID" value="KVH89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF10"/>
    <dbReference type="STRING" id="59895.A0A103XF10"/>
    <dbReference type="Gramene" id="KVH89554">
        <property type="protein sequence ID" value="KVH89554"/>
        <property type="gene ID" value="Ccrd_008455"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="35941" checksum="DD4A8FFCD0BAFA5C" modified="2016-04-13" version="1">MDQIKHNYIQGDGLKLHVAELGSESSPVVLFLHGFPEIWYTWRYQMIAVANAGFRAIAPEYRGYGLSDIPAEPQNTSFDDFVKDIATILASLSISKVFVIGKDFGTLVGYVFSFFYPEKVAGIITIGVPYIPPHAMQRLQTLPEGFYMRRWQEPGRAEAEFSRFDAKTIVRKIYILFCSSEVPIAGENQEVLDMVEASAPLPSWFTEEDLETYGALYEKSGFVTALKTPYRSLLEKIEHPDKDVDELKVEAPALLITSKGDFSFNIPGMEEYIKSGTKDYIPNLEIIYLPEGCHFVPEQFPDKVNEHLLNFLNHNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFZ3</accession>
    <name>A0A103XFZ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPX2, central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFZ3"/>
    <dbReference type="STRING" id="59895.A0A103XFZ3"/>
    <dbReference type="Gramene" id="KVH90043">
        <property type="protein sequence ID" value="KVH90043"/>
        <property type="gene ID" value="Ccrd_007956"/>
    </dbReference>
    <dbReference type="OMA" id="WFETAES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF15">
        <property type="entry name" value="OS06G0130200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="2">
        <location>
            <begin position="261"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="559" mass="62492" checksum="705D7A5704037944" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG07</accession>
    <name>A0A103XG07_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG07"/>
    <dbReference type="STRING" id="59895.A0A103XG07"/>
    <dbReference type="Gramene" id="KVH90094">
        <property type="protein sequence ID" value="KVH90094"/>
        <property type="gene ID" value="Ccrd_007894"/>
    </dbReference>
    <dbReference type="OMA" id="WDPVNKE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000001">
        <property type="entry name" value="Probable aquaporin PIP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="30527" checksum="62619C78F203B28A" modified="2016-04-13" version="1">MEGKEEDVKLGANKYSERQPIGTSAQTDKDYKEPPPAPLFEPGELSSWSFYRAGIAEFIATFLFLYISVLTVMGVVKSPTKCGTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLLLARKLSLTRAVFYMVMQCLGAICGAGVVKGFQGDAQFTTLGGGANVVAHGYTKGDGLGAEIVGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKSHAWDDHWIFWVGPFIGAALAAVYHQFVIRAIPFKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG14</accession>
    <name>A0A103XG14_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG14"/>
    <dbReference type="STRING" id="59895.A0A103XG14"/>
    <dbReference type="Gramene" id="KVH90090">
        <property type="protein sequence ID" value="KVH90090"/>
        <property type="gene ID" value="Ccrd_007890"/>
    </dbReference>
    <dbReference type="OMA" id="QAYQLYP"/>
    <dbReference type="OrthoDB" id="1927968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040420">
        <property type="entry name" value="At1g76660-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31798:SF14">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31798">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41078" checksum="A67AD7AA69889639" modified="2016-04-13" version="1">MRGVNDTRETINAAASAIASEENRPPHSSSVQKRRWGSFWSISSCFGSQKQKKIGHAVLVPEPSSSRTESSTIVNPSQPSSLVLPFIAPPSSPASFLQSEPPSAAQSPGGLLSFTAASSGLYSPSDPTNMFAVGPYAHERQLVSPPVFSTYTTEPSTAPVTPPPESVHLTTPSSPEVPFARFLGSANQNGEVDRKFSSSHQEFQMYQLYPGSPMGQLVSPSSGVSNSGTSSPLPDGGSVPHFLRYPTGAKRSPSEWEWREASGTMTPDPSGTQSVLDRQDSDVGPLTKFSNDDQHAIDHRVSFEITPDEVVRCVERRLTADVAGGGGDSSGDEVASHHRSTATLGSGRDFNFDSRDGGDANWWKVVGKESGGGPIKNWAFFPVGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG30</accession>
    <name>A0A103XG30_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG30"/>
    <dbReference type="STRING" id="59895.A0A103XG30"/>
    <dbReference type="Gramene" id="KVH90048">
        <property type="protein sequence ID" value="KVH90048"/>
        <property type="gene ID" value="Ccrd_007984"/>
    </dbReference>
    <dbReference type="OMA" id="DHPLREY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="167"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="655" mass="70227" checksum="D81E4DE8556071CD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIE2</accession>
    <name>A0A103XIE2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YABBY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005068">
        <property type="protein sequence ID" value="KVH91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIE2"/>
    <dbReference type="STRING" id="59895.A0A103XIE2"/>
    <dbReference type="OMA" id="PNTINPY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010158">
        <property type="term" value="P:abaxial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010154">
        <property type="term" value="P:fruit development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009944">
        <property type="term" value="P:polarity specification of adaxial/abaxial axis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000024">
        <property type="term" value="P:regulation of leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902183">
        <property type="term" value="P:regulation of shoot apical meristem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006780">
        <property type="entry name" value="YABBY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056776">
        <property type="entry name" value="YABBY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675:SF0">
        <property type="entry name" value="AXIAL REGULATOR YABBY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675">
        <property type="entry name" value="PROTEIN YABBY 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24868">
        <property type="entry name" value="YABBY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="YABBY N-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="YABBY protein C-terminal" evidence="5">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="280" mass="31189" checksum="BF66A398F9A1DEE6" modified="2016-04-13" version="1" fragment="single">LWGLINTSAILCSGSLFLLFSLTFSIVTSFSLVFENTHKHKKARSPNTINPYTLSTRSHQSIKSDSEKRSKRRGERRKSKSKKKKNMSSSAAFSPDHHHQHHLSPPSEQLCYVQCKFCETILAVSVPCSSLFTTVTVRCGHCTNLLSVNMRAHLLPASAAAAAANQLHLGHHFFSPQNIMEEMRNTPSNLLMNQPIPEPFGPVRVDELLKPPVVNRRNPDISHREAFSAAAKNWAHFPHIHFGLMPDQPLKKPNVCQQEGDDLHTKDGFLAAGNVGVSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIF4</accession>
    <name>A0A103XIF4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Ccrd_006656</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005048">
        <property type="protein sequence ID" value="KVH91323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XIF4"/>
    <dbReference type="Gramene" id="KVH91323">
        <property type="protein sequence ID" value="KVH91323"/>
        <property type="gene ID" value="Ccrd_006656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="1110"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="1379"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="25">
        <location>
            <begin position="1449"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KVH91323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1616" mass="183580" checksum="8F563F630D9C3AF8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKD1</accession>
    <name>A0A103XKD1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004825">
        <property type="protein sequence ID" value="KVH92299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKD1"/>
    <dbReference type="STRING" id="59895.A0A103XKD1"/>
    <dbReference type="Gramene" id="KVH92299">
        <property type="protein sequence ID" value="KVH92299"/>
        <property type="gene ID" value="Ccrd_005672"/>
    </dbReference>
    <dbReference type="OMA" id="MCDIEND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF537">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="267" mass="29335" checksum="A7B32CDD2FB904E5" modified="2016-04-13" version="1">MLVGDCGVKANGTTMVCVLSAVSRLGYLETGISIHGHIVKTMCDIENDVYIGTGLVDMYAKCGCLDSALNLFMRMKHKNVLTWTTMVSGLAVHGKGKQALKIFDDMIESGILPNSVTFTSLLFACSQAGLLEEGLYLFHNMKRVFHILPLPHHYGCIVDLLGRLGHLDEAYEFIISEKVEGDEVLWKSLLHACRIHDNVVMGERVAKILFSIQPEMNLEIPCDNSEDYVALSNICASAGRWEDVAAVREVISVKGIETKPAVSTVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLR7</accession>
    <name>A0A103XLR7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004799">
        <property type="protein sequence ID" value="KVH93034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLR7"/>
    <dbReference type="STRING" id="59895.A0A103XLR7"/>
    <dbReference type="Gramene" id="KVH93034">
        <property type="protein sequence ID" value="KVH93034"/>
        <property type="gene ID" value="Ccrd_004922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF60">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="20212" checksum="4C02530C2A0BF17D" modified="2016-04-13" version="1">MAGGPEHVPSLGLFKKQSSSSGEMDECPYEFNWRNSKHQEGEKVKNKTTKRQGQDCAHQLFDEITVRVFKSMNPDQTKLISLPSCLTPNGTYKTLLFWFEADNWISRMQQQKKTLGSRPPGCVNKCMNCTPCRATLVIPPHHRMTDYRDQSSHREDDCYYLLSWKCKCGDKLFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMH4</accession>
    <name>A0A103XMH4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004773">
        <property type="protein sequence ID" value="KVH93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMH4"/>
    <dbReference type="STRING" id="59895.A0A103XMH4"/>
    <dbReference type="Gramene" id="KVH93405">
        <property type="protein sequence ID" value="KVH93405"/>
        <property type="gene ID" value="Ccrd_004543"/>
    </dbReference>
    <dbReference type="OMA" id="WENHCAL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118935" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18631" checksum="BDD8EEDA8AD2BB4E" modified="2016-04-13" version="1">MIGSRSGTLIAALVLLGLGSMGLVWASVEAGNISTTNTLQCPPFRLSYRGLGEPLCFAAFGPFATTAFYLMQGGSTTVERLPITATILSASLLVGITTTLILFCSHFHQVRIGTETGSNVVKVAVISLYSLDKTKIFMAKYFCVRLHAIFGVALTAGMVAARIITSNNVPQPIVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMY4</accession>
    <name>A0A103XMY4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004603">
        <property type="protein sequence ID" value="KVH93771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMY4"/>
    <dbReference type="Gramene" id="KVH93771">
        <property type="protein sequence ID" value="KVH93771"/>
        <property type="gene ID" value="Ccrd_004173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="9669" checksum="055C23DCE6979120" modified="2016-04-13" version="1">MSYVAKTNRGWSFKNHADGYSNGNDGYYNPASAKLQRDGDDDDADYDYAPAAISEADGDDDDADYDYAPAASEADGDNDDDGDYDYAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN12</accession>
    <name>A0A103XN12_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004609">
        <property type="protein sequence ID" value="KVH93737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN12"/>
    <dbReference type="Gramene" id="KVH93737">
        <property type="protein sequence ID" value="KVH93737"/>
        <property type="gene ID" value="Ccrd_004210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="70" mass="7587" checksum="DD3DF99D01D23783" modified="2016-04-13" version="1">MVEVVLRFQVSGRGEGKERTVKKFSSPKIPVLFHGKELQVMGGGSGINNGNVGGGRTYNPPAFKELQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR27</accession>
    <name>A0A103XR27_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Legume lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004392">
        <property type="protein sequence ID" value="KVH95333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR27"/>
    <dbReference type="STRING" id="59895.A0A103XR27"/>
    <dbReference type="Gramene" id="KVH95333">
        <property type="protein sequence ID" value="KVH95333"/>
        <property type="gene ID" value="Ccrd_002576"/>
    </dbReference>
    <dbReference type="OMA" id="HISRMVL"/>
    <dbReference type="OrthoDB" id="768690at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010605">
        <property type="entry name" value="DUF1191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512:SF4">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06697">
        <property type="entry name" value="DUF1191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119021" description="Legume lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32724" checksum="F6637019C4E5C06B" modified="2016-04-13" version="1">MEDIMILLFLLCSSFCSFAQSFDSKHIATAAEPLDFILQDHALKSLLFHRQRNETGTLYEIKLPASLSGMDVSYVRLRSKTLWRKGANFSSFQIPSRTLPMPYVKRVVIMYQDLGNLSYQLYNHTVPGYSLVSSVVGFRVYDASNPTTGNVRKLDFNTSEAPISVRFPNLKFPRGAKCASFGVSNGKVSVGEISVGNVCHTRSYGRFSVVIPKRKKAVGVWVWWGVGSVTVLLVSFIGMVLVKIIKVKRLDEMEMQMEEGSVDLETVWIGYSKMPCATVTRTHPNLENAGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR83</accession>
    <name>A0A103XR83_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004390">
        <property type="protein sequence ID" value="KVH95423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR83"/>
    <dbReference type="STRING" id="59895.A0A103XR83"/>
    <dbReference type="Gramene" id="KVH95423">
        <property type="protein sequence ID" value="KVH95423"/>
        <property type="gene ID" value="Ccrd_002525"/>
    </dbReference>
    <dbReference type="OMA" id="GDHWIFW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000063">
        <property type="entry name" value="Putative aquaporin PIP-type 7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34059" checksum="24B8151A525D29BD" modified="2016-04-13" version="1">MEGKEEDVKLGANKFSERQPIGTSAQSDSKDYKEPPPAPFFEPGELSSWSFYRAGIAEFIATFLFLYISVLTVMGVVKSPTKCGTVGIQGIAWAFGGMIFALVYCTAGISVSFSANPLCFPFYLFKFAEYVYMVLVKTGGHINPAVTWGLLLARKLSVTRALFYMVMQCLGAICGAGVVKGFMGKNQFNTLGGGANVVAHGYTKGDGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKKHAWDDHWVFWVGPFIGATLAALYHVIVIRAIPFKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRS2</accession>
    <name>A0A103XRS2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004379">
        <property type="protein sequence ID" value="KVH95698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRS2"/>
    <dbReference type="Gramene" id="KVH95698">
        <property type="protein sequence ID" value="KVH95698"/>
        <property type="gene ID" value="Ccrd_002227"/>
    </dbReference>
    <dbReference type="OMA" id="RCANHMK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF4">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25238">
        <property type="entry name" value="OGFOD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0847">Vitamin C</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="25147" checksum="167D44BD2CD529D3" modified="2016-04-13" version="1">MRIFFSPQPLYRELYTLNPATFFVHSFVKAFSASDKNKDESIRSIVSEPTPGVYTFDMLQPRFCEMLLSEILTSSVNVILSLGVKHPTFPFSSLTLEDILLIPIMDLWLSTEWIEMSNWSWEVPDLSLGVIVSMAVMQAWHKLRKKSHGSFHVDDSEVTLNVCLGKQFTGGELFFRDVRCEKHVNSETHPEELLFQISFVYCDPHTTSKLTYLRGEING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS28</accession>
    <name>A0A103XS28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex with RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004376">
        <property type="protein sequence ID" value="KVH95823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS28"/>
    <dbReference type="STRING" id="59895.A0A103XS28"/>
    <dbReference type="Gramene" id="KVH95823">
        <property type="protein sequence ID" value="KVH95823"/>
        <property type="gene ID" value="Ccrd_002101"/>
    </dbReference>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="39253" checksum="AA59F652B5D744EC" modified="2016-04-13" version="1" fragment="single">MAEVVSLMEVDDDNPSQDNKGKAVVASGGGPPPHTKATPWVEKFRPQSLADVAAHRDIIDTIDRLTSENKMPHLLLYGPPGTGKTSTILAVARKLFGVQMHNMVLELNASDERGIDVVRQQIQDFASTQSFSFGAKASVKLVLLDEADAMTKDAQFALRRVIERYTKSTRFALICNNVNKIIPALQSRCTRFRFAPLDPVHVTERLKHVITAEGLDVTEDGLAALVRLSNGDMRKALNILQSTDMASQQITEEAVYLCTGNPLPKDIEQISYWLLNEPFSYSFQKISDIKATKGLALVDIVREVTMIKMPSDVRIQLINDLADVELQLGSVIAAFTRARSALVAAAKWTAVLDRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSH8</accession>
    <name>A0A103XSH8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF630 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004363">
        <property type="protein sequence ID" value="KVH96048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSH8"/>
    <dbReference type="STRING" id="59895.A0A103XSH8"/>
    <dbReference type="Gramene" id="KVH96048">
        <property type="protein sequence ID" value="KVH96048"/>
        <property type="gene ID" value="Ccrd_001868"/>
    </dbReference>
    <dbReference type="OMA" id="GRDNQPT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF49">
        <property type="entry name" value="NITRATE REGULATORY GENE2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="477"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71724" checksum="5CF1977D18026B7E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTZ1</accession>
    <name>A0A103XTZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004149">
        <property type="protein sequence ID" value="KVH96824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTZ1"/>
    <dbReference type="Gramene" id="KVH96824">
        <property type="protein sequence ID" value="KVH96824"/>
        <property type="gene ID" value="Ccrd_001084"/>
    </dbReference>
    <dbReference type="OMA" id="CIAECLI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF8">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="21320" checksum="55EA55F42181AC2B" modified="2016-04-13" version="1">MATVNDTTAVEVENQQPEQGGRGVVKRKPVFVKVGELKPGTNGHTLAVKVLSSTTVLDKKSRNSSSFSSRPGAANTRIAECLIGDETGTILFTARNDQGKPSAVFLDKKRNETWFCKLVNRLLLMDDALGAFFDLMKPGNTVIIRNAKIDMFKGSMRLAVDKWGRIEVTEPASFTVKEDNNLSLVEYELVNVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUQ0</accession>
    <name>A0A103XUQ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003848">
        <property type="protein sequence ID" value="KVH97221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUQ0"/>
    <dbReference type="STRING" id="59895.A0A103XUQ0"/>
    <dbReference type="Gramene" id="KVH97221">
        <property type="protein sequence ID" value="KVH97221"/>
        <property type="gene ID" value="Ccrd_000669"/>
    </dbReference>
    <dbReference type="OMA" id="DIAVAWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF695">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="20288" checksum="B34583C6D4E1B5D1" modified="2016-04-13" version="1">MAGDKVKLLGFWGSPFALRVEWALRLKGVEYEYVEEDLSNKSPMLLQYNPLYKKFVPLIIKMSSSTREQKDKVAEEAREVLKTLESSLNQNKPFYGGKILGFMDIAVAWIGIWAPMLEKIIDIKLLDEEYMPLLNTWFRDVLEVLVIKECIPPLDKLLAHYKDYYDRFMATKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVQ8</accession>
    <name>A0A103XVQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, MYND-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVQ8"/>
    <dbReference type="STRING" id="59895.A0A103XVQ8"/>
    <dbReference type="Gramene" id="KVH97755">
        <property type="protein sequence ID" value="KVH97755"/>
        <property type="gene ID" value="Ccrd_000110"/>
    </dbReference>
    <dbReference type="OMA" id="GMWMYEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47570">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47570:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="39294" checksum="55A1D1673C763341" modified="2016-04-13" version="1">MECAAKGSRRRCSGSANRRCGGCGAVSYCSVAHQISHWGVHKEECGRLKRQMCAVELLNDFPFTFSQGATYQVCEKVETRCSFLENMAVHYVGFWICECTCGASVTLLDNFRSDKCWSLSSQLCPCRGPLSILKNQLYSWNDYYEWRGIPLDSPVAVLLHWPLTIYQAIQLASEKQLIPSTTDELCIHYLGPERELYQLAVFGELHALLPGVQVHIDFVGPSVPHDRDGETISLCSYAHCLDANCSCKSGKGEFSSHATSDKSSAISIRLHSGCYHDRYRELTKELIREIEIPAIFSDYCEEACHLAANCISSVTDGMILPQVQLNPFRQPLAVEDSVLALPCYSNCFLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVY0</accession>
    <name>A0A103XVY0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ovarian tumor, otubain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003816">
        <property type="protein sequence ID" value="KVH97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XVY0"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36068">
        <property type="entry name" value="OS01G0102500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36068:SF1">
        <property type="entry name" value="OS01G0102500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="I or L" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42318" checksum="930C172CF8615A91" modified="2016-04-13" version="1">MGKLICDSTTSSPVIPWKDPTAAPSSIDTIAAVDLSDEILNAATTTWDDVSGLEDQQKRHLQRLHAKGVLWKHPGNKIPNQCQNQNQEDDTSLPAAVVFRLSHGGDVEADGNCLFTASQKAMGLTEINAKDLRRRTVRRFLEDLGSESGMERANIDAAIKHMYAPDLRSGWGIHVVQEVKLLAKKVDRESLDAAIEELVNLGMQRELAAESIYKERCIAVDNGQNWAKYMSISGSPDDEYNIITLQYTEEGLLTVDENREGHAAAFGDDIAIECLATEFKREIYVVCCLXLLSTCIFFKCVFKCLTWGLMVLVLVQAHGSDAMVDEDNCVFFLPHRPRSEICGPPFFLFMKGTGWCGAGGDHYEPLIAHSSSVVSQEKVALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW13</accession>
    <name>A0A103XW13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003815">
        <property type="protein sequence ID" value="KVH97940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW13"/>
    <dbReference type="Gramene" id="KVH97940">
        <property type="protein sequence ID" value="KVH97940"/>
        <property type="gene ID" value="Ccrd_023866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="25" mass="2802" checksum="866242D2700088BA" modified="2016-04-13" version="1">MGHSNIWNSHPKLYGPGSRTWSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW22</accession>
    <name>A0A103XW22_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW22"/>
    <dbReference type="STRING" id="59895.A0A103XW22"/>
    <dbReference type="Gramene" id="KVH97953">
        <property type="protein sequence ID" value="KVH97953"/>
        <property type="gene ID" value="Ccrd_023821"/>
    </dbReference>
    <dbReference type="OMA" id="NTSNPCF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000071">
        <property type="entry name" value="RWD domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="271" mass="30878" checksum="771F1DC6430CD37B" modified="2016-04-13" version="1">MTEQDKDIEYLFTEMFTTDHVQEQEMEIEALEAILMDELEEIHPSESGLNTSNRCFQITLSPQDDETDEYSTTPVQLGLIFSHTEKYPDEVPLLNVKSIRGIHTSDLKILKEKLEQEALENLGMSMIYTLVSSAKDWLSEIFAQDADDDDDEEETAEKDEVIVPHGEPVTVDTFLAWRERFEAELALQRAKLMPESALATTKEKKLSGRQWFESGRASSKGAVPIEDGSDEEDEDFDFDDEEDFEDDEDDMLEHYLAEKSDSSAHSSARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW46</accession>
    <name>A0A103XW46_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW46"/>
    <dbReference type="STRING" id="59895.A0A103XW46"/>
    <dbReference type="Gramene" id="KVH97954">
        <property type="protein sequence ID" value="KVH97954"/>
        <property type="gene ID" value="Ccrd_023820"/>
    </dbReference>
    <dbReference type="OMA" id="MYDIEES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044679">
        <property type="entry name" value="PWWP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33697">
        <property type="entry name" value="T17B22.17 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33697:SF1">
        <property type="entry name" value="TUDOR_PWWP_MBT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="739" mass="81041" checksum="BA24E0CD422A16F6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXS9</accession>
    <name>A0A103XXS9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP40/DnaJ peptide-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXS9"/>
    <dbReference type="STRING" id="59895.A0A103XXS9"/>
    <dbReference type="Gramene" id="KVH98871">
        <property type="protein sequence ID" value="KVH98871"/>
        <property type="gene ID" value="Ccrd_022893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF524">
        <property type="entry name" value="DNAJ HEAT SHOCK FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chaperone DnaJ C-terminal" evidence="3">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="23893" checksum="CCDC261C60AD959F" modified="2016-04-13" version="1">MERRHPPPSSSFNPRNSDDVFGDVGGAVTPPPSSPINPRNSGFERDHPSGGAAMSENRRFKDGASRFSNGLGSSMARKAPAAETLLPCSLEDMYTGGKKKIEISRKSSSNHHGVEILTFEIRLGWRKGTEITFVEKGNQETVYTRDDNDLIINQKILLLEALTGKTIELTTLDGRNLVILVTEVIKPGYGLILPKAQRSIKINLRKTLHKYTSNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYN7</accession>
    <name>A0A103XYN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lateral Root Primordium type 1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHI protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003618">
        <property type="protein sequence ID" value="KVH99313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYN7"/>
    <dbReference type="STRING" id="59895.A0A103XYN7"/>
    <dbReference type="Gramene" id="KVH99313">
        <property type="protein sequence ID" value="KVH99313"/>
        <property type="gene ID" value="Ccrd_022456"/>
    </dbReference>
    <dbReference type="OMA" id="CTHNTLG"/>
    <dbReference type="OrthoDB" id="692274at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007818">
        <property type="entry name" value="SHI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006511">
        <property type="entry name" value="SHI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006510">
        <property type="entry name" value="Znf_LRP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01624">
        <property type="entry name" value="LRP1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01623">
        <property type="entry name" value="put_zinc_LRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31604">
        <property type="entry name" value="PROTEIN LATERAL ROOT PRIMORDIUM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31604:SF2">
        <property type="entry name" value="PROTEIN SHI RELATED SEQUENCE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05142">
        <property type="entry name" value="DUF702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH99313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="42351" checksum="6CE4A0EDFE36A3B4" modified="2016-04-13" version="1">MSGFFSLGGGIGIGKVDEEHHHHLQDQEHDDGIISPQSLYLFKNEEIYSKGFELWQECYQFHQHRQHLYQPPQHYDQLGVGSRSDRRRSSSVSSGVSGGVDDLDRNASSWNIFGGVGSTVMRQGGYGIGGGSGSGSGSGSGSGMNCQDCGNQAKKDCEHMRCRTCCKSRGFHCQTHVKSTWVPAAKRRERQHQLMSLTQQQHHHQHQQDLGNQQLSLMMRASGGGESGDDQIPKRLREDHQHQPSIAVAGSGGGMGMILPAPQHHNTSGLEVGHFPAEVNSPAVFRCVRVSAMDEAEEQLAYQTALNIGGHVFKGILYDHGPEGRYNNPGEGSSSGGGGAQLQQLITSGRTAGATASTSIHPAVNFIDPSSTYPTPFSAFMAGTQFFPPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZL5</accession>
    <name>A0A103XZL5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_021991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="LEKV01003414">
        <property type="protein sequence ID" value="KVH99766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZL5"/>
    <dbReference type="STRING" id="59895.A0A103XZL5"/>
    <dbReference type="Gramene" id="KVH99766">
        <property type="protein sequence ID" value="KVH99766"/>
        <property type="gene ID" value="Ccrd_021991"/>
    </dbReference>
    <dbReference type="OMA" id="TWAQANH"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000013">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF98">
        <property type="entry name" value="PECTINESTERASE 67-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="5 11" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="58"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH99766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="358" mass="40312" checksum="72663299446FA699" modified="2016-04-13" version="1">MFRLPLIMFKMINVAYVFMLITSMYFLDGVADKGVLTLKPTRVDATLLTSKIGSNRTIIVDIHGSEDFMSVQDAIDSIPLGNPNWVIIHVKEGVYREKVRIPREKPRIFLKGSGRTKTSIVWSQSSENNYESSTFKVEAPYFVAYGISFKNDAPTGIANTSHNQSVAAYVGADKVAFYSCGFYSNHNTLLDNKGRHYYDGCYIQGSIDVIFGRARSIFHDCEILVIMDNRMEILGSVTAHSRTSTNENTGFVFIRGKIYGTGHAFLGRPKGDHSRVVFVNTYMSKSVRPEGWSKWNHNGNLENIYHAEYDCHGPGSATNNRAKWLKKLSDEEVAPFLSTDFIDGKKWLITDHVSTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZN5</accession>
    <name>A0A103XZN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Berberine/berberine-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_021966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XZN5"/>
    <dbReference type="Gramene" id="KVH99824">
        <property type="protein sequence ID" value="KVH99824"/>
        <property type="gene ID" value="Ccrd_021966"/>
    </dbReference>
    <dbReference type="OMA" id="CHIISSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000004">
        <property type="entry name" value="Berberine bridge enzyme-like 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119241" evidence="12">
        <location>
            <begin position="27"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="76"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH99824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="759" mass="85040" checksum="5F75D65128F140AA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZR9</accession>
    <name>A0A103XZR9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_021867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003407">
        <property type="protein sequence ID" value="KVH99891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZR9"/>
    <dbReference type="STRING" id="59895.A0A103XZR9"/>
    <dbReference type="Gramene" id="KVH99891">
        <property type="protein sequence ID" value="KVH99891"/>
        <property type="gene ID" value="Ccrd_021867"/>
    </dbReference>
    <dbReference type="OMA" id="TPQYKAK"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH99891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="19725" checksum="B4D77641F851E5C5" modified="2016-04-13" version="1">MSGVGKKVADVAFKASKSIDWDGMAKMIVTDEARKEFSSLRRAFEEVNSTLQTKFSQEPEPIDWEYYRKGLGSRIVDSYKEYYESVEIPKFVDKTTAEYKPKFDALLVELKEAEQKSLKESERLEKEIAEVQELKTKLSTMTADEYFEKHPELKKKFDDEIRNDYWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y099</accession>
    <name>A0A103Y099_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y099"/>
    <dbReference type="STRING" id="59895.A0A103Y099"/>
    <dbReference type="Gramene" id="KVI00160">
        <property type="protein sequence ID" value="KVI00160"/>
        <property type="gene ID" value="Ccrd_021621"/>
    </dbReference>
    <dbReference type="OMA" id="PTTECCD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01959">
        <property type="entry name" value="nsLTP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033872">
        <property type="entry name" value="nsLTP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214:SF85">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_PLANT LIPID TRANSFER PROTEIN_SEED STORAGE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="102" mass="11073" checksum="D7CC7727B2435F48" modified="2016-04-13" version="1">MEISPSYVGPRCFTVVVMVVMLLFTGNLQLTEAQTRCDPVELSWCLQAIVSNIPPSRTCCRKLKGQEACLCREKTDPTFGAYLGLPGAKRVAAACGVTFPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0M2</accession>
    <name>A0A103Y0M2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0M2"/>
    <dbReference type="STRING" id="59895.A0A103Y0M2"/>
    <dbReference type="Gramene" id="KVI00339">
        <property type="protein sequence ID" value="KVI00339"/>
        <property type="gene ID" value="Ccrd_021332"/>
    </dbReference>
    <dbReference type="OMA" id="INQEESV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044655">
        <property type="entry name" value="BAGP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47038">
        <property type="entry name" value="BAG-ASSOCIATED GRAM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47038:SF1">
        <property type="entry name" value="BAG-ASSOCIATED GRAM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="380"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI00339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="569" mass="63905" checksum="838974A430FC860F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0N5</accession>
    <name>A0A103Y0N5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 35 member SLC35F1/F2/F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003393">
        <property type="protein sequence ID" value="KVI00276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0N5"/>
    <dbReference type="Gramene" id="KVI00276">
        <property type="protein sequence ID" value="KVI00276"/>
        <property type="gene ID" value="Ccrd_021471"/>
    </dbReference>
    <dbReference type="OMA" id="IHWSTEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37451" checksum="11D8EF35D24D2331" modified="2016-04-13" version="1">MVSVKEFLANKTVVGLLLGQILSLLITSTGFSSSELARRGINAPTSQSLANYVMLAVVYGGILIHRGRGLKAKWYYYLLLGLVDVEANYLVVKAYQYTSITSIMLLDCWSIPSVILLTWLFLKTKYRFKKIAGVAICVAGLVLVIFSDVHAADRSQNGSSPIKGDFLVVAGATLYAVSNVSEEFFVTTADRIELMAMLGFFGAILLPYTGFAAAMFLFYSGVPVLLKMSGSTMLNLSLLTSDMWSVLIRIFAYHEKVDWMYFVAFAAVAVGLVVYSGFDKETRSEVADGTEQSKYLDEEAGVTSSSKPNVASSSSNKHEFASTSKTNTESSIYKGKDSPIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0U5</accession>
    <name>A0A103Y0U5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EF-Hand 1, calcium-binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003388">
        <property type="protein sequence ID" value="KVI00464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0U5"/>
    <dbReference type="STRING" id="59895.A0A103Y0U5"/>
    <dbReference type="Gramene" id="KVI00464">
        <property type="protein sequence ID" value="KVI00464"/>
        <property type="gene ID" value="Ccrd_021282"/>
    </dbReference>
    <dbReference type="OMA" id="WSTSRHC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03882">
        <property type="entry name" value="M28_nicalin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="532" mass="58498" checksum="07F1506109FB329B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1H9</accession>
    <name>A0A103Y1H9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein RETICULATA-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_020944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETICULATA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003245">
        <property type="protein sequence ID" value="KVI00807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1H9"/>
    <dbReference type="STRING" id="59895.A0A103Y1H9"/>
    <dbReference type="Gramene" id="KVI00807">
        <property type="protein sequence ID" value="KVI00807"/>
        <property type="gene ID" value="Ccrd_020944"/>
    </dbReference>
    <dbReference type="OMA" id="VCADVIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021825">
        <property type="entry name" value="RETICULATA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620:SF8">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 4, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11891">
        <property type="entry name" value="RETICULATA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39304" checksum="5C870B64D3DC0570" modified="2016-04-13" version="1">MAVTTIRSFTLQSPNNHHRCRHSNSRHLTTPLNLKIVTHTHKTHLSFTLNKLHNRLPPLTRSYSGGNGDDGVGGGGGGGGGGGGEDGDDDAGEKNKAEAFLALAEAGRSLESIPKDIAASIDAGKIPGSIVKRYLELEKSAVFRWLLQFGGFKERLLADDLFLTKVGIECGVGIFTKSAAELEKRRENFTKELDFVFADVIMAIIADFMLVWLPAPTVSLRSPIAINAGRVAKFFSGCPDNAFQVALAGTSYSFLQRIGAIVRNGAKLFAVGTGASLVGTGITNGLINARKAIDKSFAVEAEEDIPILSTSVAYGVYMAVSSNLRYQVLAGVIEQRMLEPLLHQHKLILSAVCFAVRTGNTFLGSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1V6</accession>
    <name>A0A103Y1V6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003155">
        <property type="protein sequence ID" value="KVI00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1V6"/>
    <dbReference type="Gramene" id="KVI00966">
        <property type="protein sequence ID" value="KVI00966"/>
        <property type="gene ID" value="Ccrd_020778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119315" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="83" mass="9311" checksum="C3963C7CC725498E" modified="2016-04-13" version="1">MTGFKLWWIKGTFATLMLLIPGNLAWGKEGHYATCKIAEKKRSEILLPSFGYSATHPPINFTCTTRKKQQDHTGKGITEEGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2A6</accession>
    <name>A0A103Y2A6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malectin-like carbohydrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2A6"/>
    <dbReference type="Gramene" id="KVI01220">
        <property type="protein sequence ID" value="KVI01220"/>
        <property type="gene ID" value="Ccrd_020524"/>
    </dbReference>
    <dbReference type="OMA" id="AVNWMDI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45631:SF143">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45631">
        <property type="entry name" value="OS07G0107800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="333"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="709" mass="79298" checksum="68EC804E2D98E32C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y446</accession>
    <name>A0A103Y446_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apple-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y446"/>
    <dbReference type="Gramene" id="KVI02170">
        <property type="protein sequence ID" value="KVI02170"/>
        <property type="gene ID" value="Ccrd_019451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000004">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF98">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119370" description="Apple-like protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="5">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="346"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="69054" checksum="72B31AE1D388B36E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5A4</accession>
    <name>A0A103Y5A4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor, K-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002639">
        <property type="protein sequence ID" value="KVI02754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5A4"/>
    <dbReference type="Gramene" id="KVI02754">
        <property type="protein sequence ID" value="KVI02754"/>
        <property type="gene ID" value="Ccrd_018944"/>
    </dbReference>
    <dbReference type="OMA" id="DSHAPIQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000003">
        <property type="entry name" value="MADS-box transcription factor MADS-MC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51297">
        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="19669" checksum="20826BD5EC28AE48" modified="2016-04-13" version="1" fragment="single">MGRGKIAIRRIDNSTSRQVTFSKRRNGLLKKAKELAILCDADVGVIIFSSTNKLYEFSSTSMKSVVQRYNRSKEEINQLVNPMSDVKIRQLMGEELCGLGLEDLQKLENQLSLSLQVIRMKKEESLTNEIQELTRKRVTLVSSKLIALPICIYVNLRIRVCLTYRCVKQFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y610</accession>
    <name>A0A103Y610_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002480">
        <property type="protein sequence ID" value="KVI03145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y610"/>
    <dbReference type="STRING" id="59895.A0A103Y610"/>
    <dbReference type="Gramene" id="KVI03145">
        <property type="protein sequence ID" value="KVI03145"/>
        <property type="gene ID" value="Ccrd_018561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF123">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="269" mass="30366" checksum="19F978C682035863" modified="2016-04-13" version="1">MEVLRLSRFPDDTRPIQILDTLMPLYLNTQILREAKGEWSSIYEDGVVCIACIFMMERYEILKDIGSGNFGVAKLVKDKSSGDLFAVKYIDRGQKMKALRPASKSAISDILSHRFCIRSPNQQSGHLRISPQKSCRKKSTTIADVWSCGVTLYVMLVGAYPFEDPDDPRNFRKTLARITILEIKKHPWFVKNMTIDVMEDEESGAEVEKADTPSQSTEEVIAIIQEARKSPMGSKEEGEFVGMDLEDEIDSDDEFEDDVDTSGDFVCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6R4</accession>
    <name>A0A103Y6R4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_018172</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01002345">
        <property type="protein sequence ID" value="KVI03535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6R4"/>
    <dbReference type="STRING" id="59895.A0A103Y6R4"/>
    <dbReference type="Gramene" id="KVI03535">
        <property type="protein sequence ID" value="KVI03535"/>
        <property type="gene ID" value="Ccrd_018172"/>
    </dbReference>
    <dbReference type="OMA" id="FRLKSAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000016">
        <property type="entry name" value="Carbon catabolite repressor protein 4 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="253"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI03535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="562" mass="61778" checksum="CD9AC24C50AFA362" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7D9</accession>
    <name>A0A103Y7D9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7D9"/>
    <dbReference type="STRING" id="59895.A0A103Y7D9"/>
    <dbReference type="Gramene" id="KVI03876">
        <property type="protein sequence ID" value="KVI03876"/>
        <property type="gene ID" value="Ccrd_017830"/>
    </dbReference>
    <dbReference type="OMA" id="SWLEHEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14220" checksum="A2F14D2BFCF277C7" modified="2016-04-13" version="1">MPFKRYVEIGRVGLVNYGKDYGKLVVIVDVIDQNRGAIADCYIGRFITSISPHVPEWISLLLKRLPKSDVKNKWESSSWGRKLIVQKKRASLNDFDRFKIMLAKIKEAGVVRQELAKLKKETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7Q1</accession>
    <name>A0A103Y7Q1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002312">
        <property type="protein sequence ID" value="KVI04062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7Q1"/>
    <dbReference type="STRING" id="59895.A0A103Y7Q1"/>
    <dbReference type="Gramene" id="KVI04062">
        <property type="protein sequence ID" value="KVI04062"/>
        <property type="gene ID" value="Ccrd_017639"/>
    </dbReference>
    <dbReference type="OMA" id="VHAVTHK"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000022">
        <property type="entry name" value="Probable 2-oxoglutarate-dependent dioxygenase AOP1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="160"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="311" mass="35825" checksum="F04379679B2982DF" modified="2016-04-13" version="1">MVSLSQPKLPVIHMADLNPGTESWISTSQKVTQALEKYGCFVAVYERVSQQLKKEVLDSLRTPFDLPTDTKINNTSDKPFHGYMRPVPTRPLYQSLGIEHATSLDDVQRFTNLMWPSGNHHFSNTMHSYATLVTELENAVRQMVFQSYGVEKYYESFNESMNYLFKVMKYSAPKPDQTNLGVAVHTDKSFITVLGQINEVNGLEVEIEDGKWITFEFLPLSFVVLATDPLMAWSNGRVKSPRHRVIMNGQEDRYSIVLFSYKKGIIQTPEEIVDQEHPLRFKPFDHYKFLDFVSKDENYLDEKAIKLFCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7W0</accession>
    <name>A0A103Y7W0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002305">
        <property type="protein sequence ID" value="KVI04151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7W0"/>
    <dbReference type="STRING" id="59895.A0A103Y7W0"/>
    <dbReference type="Gramene" id="KVI04151">
        <property type="protein sequence ID" value="KVI04151"/>
        <property type="gene ID" value="Ccrd_017547"/>
    </dbReference>
    <dbReference type="OMA" id="FLHKACN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010020">
        <property type="term" value="P:chloroplast fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219:SF10">
        <property type="entry name" value="OS07G0185300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="YLMG HOMOLOG PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="23531" checksum="F4071800DFB75EED" modified="2016-04-13" version="1">MASSSSSSSLSLMASQTLIPQNPTFLHPHRPSIVSLSKPKFPFSPKSLRFSLANPKKSLIIASSSSTVSPNPPAESLLIGSTRTITTLVAIALAASKVFAQKISTIAVNSNLHKNVLSITGPLFFATMSGRSGRLHTPLTVVAAGMAKWLDIYSGVLLVRVLLSWFPNIPWDRQPLSAIRLQVYGYGFYGLFISVVKVGLSLSSNFARFSYIHKQVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8R3</accession>
    <name>A0A103Y8R3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001970">
        <property type="protein sequence ID" value="KVI04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8R3"/>
    <dbReference type="Gramene" id="KVI04595">
        <property type="protein sequence ID" value="KVI04595"/>
        <property type="gene ID" value="Ccrd_017086"/>
    </dbReference>
    <dbReference type="OMA" id="VHEICDA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="162"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="369" mass="39423" checksum="BE85B29B39A4F13B" modified="2016-04-13" version="1">MVNVRKIYDVIHGLKPVLLMVVVQATLAGLNVFYKLAVNDGMSLPEEKAEIDMDGTLASGALAQNFYIKALSLTSATFVASTTNLMPAITFVLAVCFRMERLGWKTTPGAAKILGTMLGVGGAMLLTFYKGADLHLWKTNVDLLHGQHHGSGGQNSSNNMVLGSLLAIGSCISYSIWLIIQTNMVKEYPSPYSVTALTSTMGAVQAVVFGLCTERHWSAWKLGWNVRLLTVAYAGMLASGLMFTLIAWCVQMRGPLFVSAFNPLSLVLVAIAGSLVLNESLHVGSVLGAILIIFGLYFVIWGKGKEVKKVAKLCPMKESSIGTDSCAIAGESECSNIFGVVGDSESKPSSEQIGNGESKRIQVVVTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAS8</accession>
    <name>A0A103YAS8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAS8"/>
    <dbReference type="STRING" id="59895.A0A103YAS8"/>
    <dbReference type="Gramene" id="KVI05669">
        <property type="protein sequence ID" value="KVI05669"/>
        <property type="gene ID" value="Ccrd_016000"/>
    </dbReference>
    <dbReference type="OMA" id="MRHFEQE"/>
    <dbReference type="OrthoDB" id="1717827at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000443">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000541">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML101 (RPPR4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717">
        <property type="entry name" value="OS12G0527900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="139"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="494" mass="56271" checksum="1A05E4870BE60388" modified="2016-04-13" version="1">MSSSLFMHRFGKTKSLTKKSTKKYLEVALYRRLFKDGGTEVSVRQNLNLFLKSRKKAYKWEVDHTLKILRNRKRYAPALKLSETMAERGMNKTVSDQAVHLDLIAKARGISAAEAYFVDLPEQSKNHYTYGALLNHYCKELMTDKAESMFEKMKEWNLNLTSLHYNSILTLYEKTGQPERIPEIIRDMKTAEVKPDVFTYNIWMRVVAAMNDISGVERVIDEIKRDEGVSEDWTTYSNLASIYVNAGLTSKAEKALKELEKKNTYKNLSAFQHLITLYGKTGNLVEVYRVWRSLRLAFPKTANISYLNMIQVLVKLNDLPGAEKCFREWVSGCSSYDIRIANALIGAYAKAGLFEKAEELKELSRRRGAKPNAKTWEIFLNYHLEKGDIVSAVNCIDNAISTGRANGEKWVPSSTVVQKFMTHFESSKDVDAAEGFVQILEKVEDNVGVEVLESLIRIYAAAGKTTPVVRRRVKMENVELSNEGKTLLETISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCA7</accession>
    <name>A0A103YCA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein family, transmembrane-40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001825">
        <property type="protein sequence ID" value="KVI06455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCA7"/>
    <dbReference type="STRING" id="59895.A0A103YCA7"/>
    <dbReference type="Gramene" id="KVI06455">
        <property type="protein sequence ID" value="KVI06455"/>
        <property type="gene ID" value="Ccrd_015195"/>
    </dbReference>
    <dbReference type="OMA" id="LQAWQCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF12">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI06455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="262" mass="30182" checksum="7F44175D28C51CE3" modified="2016-04-13" version="1">MVNDQDHNYHPVQGIPDITNIHPQHKISLSSSSFIQNKCHGLWYTATLSIPALLFVLYLGFHLKKNIKKLSHRRSHVMIAYYILLWFSAVLNLAWCSLQVWQCMPGKKVSWNMLSLLTALGTLCLEISLVAFLLQESYASGLEALAHTFMISGLIVGADIILKAIFVFGFHVPLFMDGETTHQGKWRLWTVDELLLTCTYGYILCVHYSKPYSIVVICYHTLYLPFVYVTFLKDFFQEEDLLLDNAYYSEMKDAGFFDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCH1</accession>
    <name>A0A103YCH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, B-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001809">
        <property type="protein sequence ID" value="KVI06522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCH1"/>
    <dbReference type="Gramene" id="KVI06522">
        <property type="protein sequence ID" value="KVI06522"/>
        <property type="gene ID" value="Ccrd_015129"/>
    </dbReference>
    <dbReference type="OMA" id="KINCDVC"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009640">
        <property type="term" value="P:photomorphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000856">
        <property type="entry name" value="B-box zinc finger protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051979">
        <property type="entry name" value="B-box_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31832:SF52">
        <property type="entry name" value="B-BOX ZINC FINGER PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31832">
        <property type="entry name" value="B-BOX ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI06522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="315" mass="34451" checksum="093A4D9707A00FC5" modified="2016-04-13" version="1">MKINCDVCNKDEASVFCSADDAALCTACDHRVHDANMLAGKHPRFSILLPSPKDSPLCDICQEKKALLFCQQDRAILCKDCDVAIHKVNEHTKNHCRFLLTGVKLSSAALLPTAGNGVVPDQNWESRDQELVPIVNQTSSRTQKITTVTAQNMSPKSNGSDHGSATSSSISEYLIEMLPGWHVEDFLDSPCNFSKIGEDDPAVFWDDELLKGSMNDCFSPETMGIWVPQAPPPAAPPPAAPPEPRFHNSSQIQPYSNMGFGNQIISGSSLVFAPSNINNKITKSTGKRRSDDGNCFTVPQITPPPTNIKRSRTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD62</accession>
    <name>A0A103YD62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001540">
        <property type="protein sequence ID" value="KVI06926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD62"/>
    <dbReference type="STRING" id="59895.A0A103YD62"/>
    <dbReference type="Gramene" id="KVI06926">
        <property type="protein sequence ID" value="KVI06926"/>
        <property type="gene ID" value="Ccrd_014711"/>
    </dbReference>
    <dbReference type="OMA" id="TVLEAWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="2">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142042" checksum="6E78363ADAEE1E4E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDC3</accession>
    <name>A0A103YDC3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001531">
        <property type="protein sequence ID" value="KVI07015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDC3"/>
    <dbReference type="STRING" id="59895.A0A103YDC3"/>
    <dbReference type="Gramene" id="KVI07015">
        <property type="protein sequence ID" value="KVI07015"/>
        <property type="gene ID" value="Ccrd_014615"/>
    </dbReference>
    <dbReference type="OMA" id="QTKEMEG"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF24">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN PBP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="13610" checksum="B948A828F452E496" modified="2016-04-13" version="1">MGSEARGKLCGEEFEDMLPKMAEKLGGEGLIKELCNGFDLLMDKDKGVITFESLKYNSSLLGLQDLRDDELMSMLKEGDYDGDHALNQMEFCVLMFRLSPELMTESKALLDQVLQQEFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGY7</accession>
    <name>A0A103YGY7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, class V/Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001079">
        <property type="protein sequence ID" value="KVI08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGY7"/>
    <dbReference type="STRING" id="59895.A0A103YGY7"/>
    <dbReference type="Gramene" id="KVI08907">
        <property type="protein sequence ID" value="KVI08907"/>
        <property type="gene ID" value="Ccrd_012714"/>
    </dbReference>
    <dbReference type="OMA" id="FWIEYIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="143"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="36990" checksum="F894C9CB810D4519" modified="2016-04-13" version="1">MASKVLAAAVRRSLSPRIPTSIRSLSTAAAAVAEPFDETAGISMKGVKISGRPLYLDMQATSPVDPRVLDAMLPYFVSRYGNPHSRTHLYGWESDEAVEVARAQVANLINASPKEIVFTSGATECNNISVKGVMHFYKEKKKHGVGALYMRRRPRIRVEPQMNGGGQERGIRSGTVPTPLVVGMGAACELAMKEMEYDEKRVTKLKDRMLNGIRDRLDGVVVNGSTESRYAGNLNLSFAYVEGESLLMGLKEVAVSSGSACTSASLEPSYVLRALGVDEDMAHTSIRFGIGRFTTEEEIDKAIELTVNQVEKLREMSPLYEMVKEGIDIKSIQWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH61</accession>
    <name>A0A103YH61_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001074">
        <property type="protein sequence ID" value="KVI09020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH61"/>
    <dbReference type="STRING" id="59895.A0A103YH61"/>
    <dbReference type="Gramene" id="KVI09020">
        <property type="protein sequence ID" value="KVI09020"/>
        <property type="gene ID" value="Ccrd_012583"/>
    </dbReference>
    <dbReference type="OMA" id="QCAWARI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35831" checksum="8B3179E2C979DCDA" modified="2016-04-13" version="1">MGEEEQNPQKMKKIAAATYDFDNDPRWADYWSNVLMPPHMASRSDVITHYKRKFYQRYIDPDLVVEPMTTQSTAKSSAPSSSSSTSEHRPSHNSGSTTRATRASTLNSTPLRWDRQTIQFSVNAWVFVVAVLAMFPIIPKSLSNRAYRLSFIGTLCSSLYSLYSLYGKPRAWNLQAVQVWLQSVIATKDFIYCIYCLTFVSSNLQLRFALLPILCRSLEHSAKFLKRSTWKSFVYGWKQTQQRLAWQRNIIQTFMYWQLLKLMYQAPVTSGYHQNVWVNVGRTVNPIINQYAPFLNSPISAIQRWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHY9</accession>
    <name>A0A103YHY9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHY9"/>
    <dbReference type="Gramene" id="KVI09397">
        <property type="protein sequence ID" value="KVI09397"/>
        <property type="gene ID" value="Ccrd_012224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35755:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35755">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="17375" checksum="FB2591FDA72B2BCC" modified="2016-04-13" version="1" fragment="single">MAIQHEITRQTQTKILDTAPFMVLLLIAAHVFALVYGIYKLATSKLPQRRIETIKKRINRNEDVRMDRNMITDVKENVRERASARAKTIKNVTPSLFTCKVAKVVHIFFTLWIEQPEKDNKKELDSAAEEPVYYAYNNWRYEECCHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIB6</accession>
    <name>A0A103YIB6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_011976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIB6"/>
    <dbReference type="Gramene" id="KVI09595">
        <property type="protein sequence ID" value="KVI09595"/>
        <property type="gene ID" value="Ccrd_011976"/>
    </dbReference>
    <dbReference type="OMA" id="IFITCIW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF9">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="144" mass="16746" checksum="9C9C8199E01E78CC" modified="2016-04-13" version="1">MICVLYGGFSIPALIFITCIWVPLLQIKHAFLHFLSTLFKYYTQNQDLNHAFPNIYHRSDLQFSDLLNDGRDEVAMMSRPVDQSCSICLAEFRSDDVVSQLGRCRHVFHSCCIEGWLGRDQFTCPLCRSRLLVKPKPFNKNHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJP7</accession>
    <name>A0A103YJP7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_011212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJP7"/>
    <dbReference type="Gramene" id="KVI10386">
        <property type="protein sequence ID" value="KVI10386"/>
        <property type="gene ID" value="Ccrd_011212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26986" checksum="14C9C7954C393A0E" modified="2016-04-13" version="1">MELITSLIGRYDRRSLFLKRKDSNAGEAARALEELRGSLYNELRTSEGAKRQQQRLCGPIVALTFNFLISVGIIMGNKLALSLLPPSPPTKSTPFVMLFALGVAVATVTDLEFNLFGAGLMPWLDPPGAFSFKWGFTNTIAVLISALLGFLLQWSGALALGATSATSHVVLGQFKTCVILLGGYLLFDSDPGYASISGAFVAICGMSIYTSLNMKGTRDTSNQLPEQTSSNQKPKTIKDQNEKIDVDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLE0</accession>
    <name>A0A103YLE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ENTH/VHS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000764">
        <property type="protein sequence ID" value="KVI11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLE0"/>
    <dbReference type="STRING" id="59895.A0A103YLE0"/>
    <dbReference type="Gramene" id="KVI11229">
        <property type="protein sequence ID" value="KVI11229"/>
        <property type="gene ID" value="Ccrd_010363"/>
    </dbReference>
    <dbReference type="OMA" id="TINANHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000028">
        <property type="entry name" value="TOM1-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF2">
        <property type="entry name" value="TOM1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="552" mass="60382" checksum="C06243AF5809183E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMA0</accession>
    <name>A0A103YMA0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000049">
        <property type="protein sequence ID" value="KVI11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMA0"/>
    <dbReference type="STRING" id="59895.A0A103YMA0"/>
    <dbReference type="Gramene" id="KVI11721">
        <property type="protein sequence ID" value="KVI11721"/>
        <property type="gene ID" value="Ccrd_009865"/>
    </dbReference>
    <dbReference type="OMA" id="WVDHHGP"/>
    <dbReference type="OrthoDB" id="993453at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34807">
        <property type="entry name" value="OS08G0270800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34807:SF3">
        <property type="entry name" value="OS08G0270800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="228" mass="26497" checksum="6B985DD2E302ACFF" modified="2016-04-13" version="1">MRKKDGFDSYPHEDARFRHQTLVQDYLQLQKETETARTKLEAMKLKKLTLQAQVRFLRRRHKFLLKNKSSTRQEHTIVKPRFVETSRYRKSMNEKVYSKNEAALQNMNHNAQKKNVLLGIPSHMLHGAMEDAYYSNQAVRTNPSDLFDSSKETPVKSRPPTFDLNQISREEEEELQEGNGTKDLVRSVIDEKLNDLNLLTCGNVGLDSSTSQARKRKISWQDPVALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMM8</accession>
    <name>A0A103YMM8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_009744</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01000034">
        <property type="protein sequence ID" value="KVI11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMM8"/>
    <dbReference type="STRING" id="59895.A0A103YMM8"/>
    <dbReference type="Gramene" id="KVI11843">
        <property type="protein sequence ID" value="KVI11843"/>
        <property type="gene ID" value="Ccrd_009744"/>
    </dbReference>
    <dbReference type="OMA" id="MNCHESR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000008">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="X8" evidence="17">
        <location>
            <begin position="404"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="608" mass="66798" checksum="5C039907107B77FB" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN29</accession>
    <name>A0A103YN29_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000011">
        <property type="protein sequence ID" value="KVI12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN29"/>
    <dbReference type="Gramene" id="KVI12154">
        <property type="protein sequence ID" value="KVI12154"/>
        <property type="gene ID" value="Ccrd_009423"/>
    </dbReference>
    <dbReference type="OMA" id="LMHATFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF0">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="232" mass="26467" checksum="C9DD1C11306CAAC6" modified="2016-04-13" version="1">MDWGTVTTEDLIDALREVDWSSPPRPLNEFFSKFTVPRSSNKWNSRLKCNLYYYRTNYFLMILFILGLGFLRRPLTIVAATSTALTIAFLNDSFAGTFSEKATRTVRQFSPHLAAKMRPPLTPVLRGRPSSKRAIYICGRPRWAFVFAFSAVSFILWFASCGLFTLLWAIALGVLATILHASFRTPNLKARLNTFREEFRAVWRNYSELDTYEETCCSIFEAGLPIDAAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNH4</accession>
    <name>A0A103YNH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000007">
        <property type="protein sequence ID" value="KVI12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNH4"/>
    <dbReference type="Gramene" id="KVI12327">
        <property type="protein sequence ID" value="KVI12327"/>
        <property type="gene ID" value="Ccrd_009265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000058">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000081">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF842">
        <property type="entry name" value="KINASE SUPERFAMILY WITH OCTICOSAPEPTIDE_PHOX_BEM1P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="821"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116833" checksum="DBF9DA69ED39C2EA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRG7</accession>
    <name>A0A118JRG7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol-tetrakisphosphate 1-kinase</fullName>
            <ecNumber evidence="9">2.7.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57539"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.134"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ITPK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.134" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01006098">
        <property type="protein sequence ID" value="KVH87534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRG7"/>
    <dbReference type="STRING" id="59895.A0A118JRG7"/>
    <dbReference type="Gramene" id="KVH87534">
        <property type="protein sequence ID" value="KVH87534"/>
        <property type="gene ID" value="Ccrd_025187"/>
    </dbReference>
    <dbReference type="OMA" id="MPGYESI"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF43">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038186">
        <property type="entry name" value="ITPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="103"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH87534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36403" checksum="3066FDE9288057C5" modified="2016-04-13" version="1">MPESEPDNRFLIGYALPARKLGSFMVPTFINQAKDRGIDFVAIDVSKPLTDQSPFHCIVHKLYTDDWKLNLHDFTVSNPNTVIIDPPSAIERLQNRISMLEFVTELKIPNLSIPNQLLVEDSSSLSSVIATGKLNFPMIAKPVVVDGSAKSHKMSLVLNVEGLTKGLDLESPVVLQQFVNHGGVIFKVYVAGDYVKCVKRRSLPDISEEKLEKMSSESGGVICFSQISNSALAGDDNRSTEDSNEVKMPAPEFISETANCLRLALGLHLFNFDMIRDDKGSGYLVIDINYFPGYEKLPCYETVMTDFFLNLMKSHTVMKKTTVEGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS81</accession>
    <name>A0A118JS81_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="18">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_024408</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="18"/>
    <dbReference type="EMBL" id="LEKV01005526">
        <property type="protein sequence ID" value="KVH88196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS81"/>
    <dbReference type="STRING" id="59895.A0A118JS81"/>
    <dbReference type="Gramene" id="KVH88196">
        <property type="protein sequence ID" value="KVH88196"/>
        <property type="gene ID" value="Ccrd_024408"/>
    </dbReference>
    <dbReference type="OMA" id="HWFPFVG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000028">
        <property type="entry name" value="Cytochrome p450 51g1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20 21" id="KW-0349">Heme</keyword>
    <keyword evidence="11 20 21" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 21" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="487" mass="55197" checksum="E07D0CF72DEC156A" modified="2016-04-13" version="1">MMEVNSKFLNVAVLLIATLFAAKIISAFLIPRSRKRLPPLVKAWPLVGGLLRFLKGPVIMLKQEYPKLGSVFTLNLLNKNITFLIGPEVSAHFFKASESDLSQQEVYQFNVPTFGPGVVFDVDYSVRQEQFRFFTESLRVTKLKGYVDQMVTEAEEYFSKWGDNGEVDLKYELEHLIILTASRCLLGEEVRNKLFDDVSALFHDLDNGMLPISVIFPYLPIPAHRRRDQARKKLAEIFASIIAARKQTGKSENDMLQCFIESKYKNGRPTTESEVTGLLIAALFAGQHTSSITSTWTGAYLLANNKYMSAVVDEQKKLMEKHGNKVDHDILSEMEVLYRCIKEALRLHPPLIMLLRSSHSDFSVTTKEGREYDIPKGHIVATSPAFANRLPHIYKDPDTYDPERFDADREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELISPFPETDWNAMVVGVKGKVMVRYTRKGVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT19</accession>
    <name>A0A118JT19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005321">
        <property type="protein sequence ID" value="KVH89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT19"/>
    <dbReference type="STRING" id="59895.A0A118JT19"/>
    <dbReference type="Gramene" id="KVH89021">
        <property type="protein sequence ID" value="KVH89021"/>
        <property type="gene ID" value="Ccrd_009012"/>
    </dbReference>
    <dbReference type="OMA" id="RIMIFTM"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="228"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="482" mass="54868" checksum="DCF61D35BAA97AE7" modified="2016-04-13" version="1">MGFFLFLFLIISFLISVRLFFYRTTLIYRLKKWGHWIEDRIHVHQSLKVPQLNENNQENLFYRKVSTYLNSLSTIEDSDFTNLIYGKKPNGVVLCLDDDQTILDTFLGARVSWTNRVERIEENGLCKKTFLLKLKKKDKRRILQSYIQHIYRASEDIDSRCKELKLYMNTATLSDDHGSIGRWRSVRLTHPATLETIAMDSDLKKKVKSDLEAFLKSRQYYHRLGRVWKRSYLLYGPSGTGKSSFIAAMAKFLSYDVYDIDLSKVVDDSDLKMLLLQTSSKSLVVVEDLDRFITSNSTTVSLSGILNFMDGILNSCCGDEKLMVFTMNSKEKMDPAVLRPGRIDVHIYFPLCNFNSFKTLANNCLGVKDHKLFPQVEEIFQTGATMSPAEMSELMICNRGSPGRALRSVMTALQINGDGRKSVLAAEESSSSVAETSSVLVMDSSCSVPVVKEIQKLYGLLKMKSSKKIGPSDQFSGSMDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTB0</accession>
    <name>A0A118JTB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005240">
        <property type="protein sequence ID" value="KVH89336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTB0"/>
    <dbReference type="STRING" id="59895.A0A118JTB0"/>
    <dbReference type="Gramene" id="KVH89336">
        <property type="protein sequence ID" value="KVH89336"/>
        <property type="gene ID" value="Ccrd_008676"/>
    </dbReference>
    <dbReference type="OMA" id="CLFIEAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF75">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 32 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="34600" checksum="36EAF9CB93EEC40B" modified="2016-04-13" version="1" fragment="single">FSNHRPKSRNRVHRCLEIFTVLIRRRSYTKTIMFTRVFGKPKQEANAVTTLDKLNEACLFIEANGSQLGKGKSSAVRKLLSSLFPLLCTHPYFSKNWNTIYVASLDMCPICFLQTLEMLEKKEKVLLKKASAEVEKAKDYTRAKNKRAAIQCLKRKKLYEQQIEQLGNFQLRIHDQMIMLEGAKATTETVDALRTGAAAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALATPIGAAADFDEDELEAELEELEGAELEEQLLQPATTAPAAPVQVPAGRQPTRPAPRQNTAEEDELAALQAEMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTN3</accession>
    <name>A0A118JTN3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005079">
        <property type="protein sequence ID" value="KVH91089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTN3"/>
    <dbReference type="STRING" id="59895.A0A118JTN3"/>
    <dbReference type="Gramene" id="KVH91089">
        <property type="protein sequence ID" value="KVH91089"/>
        <property type="gene ID" value="Ccrd_006884"/>
    </dbReference>
    <dbReference type="OMA" id="WETEQFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043424">
        <property type="entry name" value="BLT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071:SF9">
        <property type="entry name" value="INTRACELLULAR PROTEIN TRANSPORT PROTEIN USO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="46917" checksum="FF09E7C98BB38433" modified="2016-04-13" version="1" fragment="single">MGNDEKQELSGIKLKNGILIGKKANKTTPSKLGFHNSSSLLRNFPMNNSVSARKIGANLWEVQPQFNFSKDHADHGGAAANLSHHRRRRHRSHDIERFEDSDRLDEKQPPDSDPQPVTPFIKAATPIGYTVKTSTHLLKILNRIWNLEEQHSLNVALIKTLKRELGISRAQITTLIEERKRDRQEMDEWKKSINDRKKKAIESTRDELLDIKSSLMRERKARILLESLCDEFANGIRDYEQKVRFLQQNRGKKDQLVSENEPDRLILHVSEAWLDERVQMKCDFSEKTSISDNLCCEIETFLEAKKKQSRGSGVEPDELLENTEPSLQLVPRMTDRSLGVAEPSSQLMSRMERLQDHGGAEPSMPRRAGRGSDATEPSSKSITRGRDRGSGVAEPRAREGAKSNTLMAKLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUG3</accession>
    <name>A0A118JUG3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004942">
        <property type="protein sequence ID" value="KVH91492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUG3"/>
    <dbReference type="STRING" id="59895.A0A118JUG3"/>
    <dbReference type="Gramene" id="KVH91492">
        <property type="protein sequence ID" value="KVH91492"/>
        <property type="gene ID" value="Ccrd_006483"/>
    </dbReference>
    <dbReference type="OMA" id="CPELEWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000023">
        <property type="entry name" value="F-box/LRR-repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000651">
        <property type="entry name" value="F-box/LRR-repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001196">
        <property type="entry name" value="F-box/LRR-repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF41">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="640" mass="69679" checksum="F1D85F2AC490088E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUL6</accession>
    <name>A0A118JUL6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chlorophyll A-B binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004911">
        <property type="protein sequence ID" value="KVH91689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUL6"/>
    <dbReference type="STRING" id="59895.A0A118JUL6"/>
    <dbReference type="Gramene" id="KVH91689">
        <property type="protein sequence ID" value="KVH91689"/>
        <property type="gene ID" value="Ccrd_006283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15679" checksum="7DB388FDAEF22971" modified="2016-04-13" version="1">MAATSVFMATPFTRLSATQLPSFNKNSAFSISNGGVAVFVVTSVVLSVASLVPLLKGVSVQSKSKGIMTSDAELWNGRFAMLGLVGLAFTEFTPLNIEANDGQWRRIEGGYIRCRHKMLCLYLWWRNDEVSSKNRYRIHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUR0</accession>
    <name>A0A118JUR0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_006113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUR0"/>
    <dbReference type="STRING" id="59895.A0A118JUR0"/>
    <dbReference type="Gramene" id="KVH91869">
        <property type="protein sequence ID" value="KVH91869"/>
        <property type="gene ID" value="Ccrd_006113"/>
    </dbReference>
    <dbReference type="OMA" id="HEQHAPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000016">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000154">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045845">
        <property type="entry name" value="BSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863:SF51">
        <property type="entry name" value="TRANSFERASE, PROTEIN KINASE RLK-PELLE-RLCK-XII-1 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH91869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="448" mass="50172" checksum="C916FE0FC5A4BBF5" modified="2016-04-13" version="1">MPLTMLRTATSGFAVENIVSEHGEKAPNVVYKGKLENQRRIAVKRFNRAAWPDSRQFLEEAKTVGQLRSPRLANLLGCCSEGDERLLVAEFMPHETLAKHLFHCKLVNKITFSIELTGGHSSKKAWIFFAILETGETQPMKWAMRLRVALYLAEALEYCTSKGRALYHDLNAYRIVFGDDANPRLSCFGLMKNSRDGKRRVTPESVIYSFGTLLLDLLSGKHIPPSHALDLIRDRNLQMLTDSCLEGQFSNDDGTELVRLASRCLQYEPRERPNPRSLVTALIPLQKETEVPSHVLMGIPQGGSAMPLTPLGEACLRRDLTFIHEILEKLGYKDDEGAATEDTLNSKKKGDSAFRHKDFKAAIDFYTQFIEVGTMVSPTVFARRSLSHLMNETPQEALNDAVQAQVISPIWHIASYLQAAALFALGRENEAQIALREGSVLEEKQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV32</accession>
    <name>A0A118JV32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chitin-binding, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Defense against chitin-containing fungal pathogens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004841">
        <property type="protein sequence ID" value="KVH92157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JV32"/>
    <dbReference type="Gramene" id="KVH92157">
        <property type="protein sequence ID" value="KVH92157"/>
        <property type="gene ID" value="Ccrd_005812"/>
    </dbReference>
    <dbReference type="OMA" id="IFTHRNG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.20.10">
        <property type="entry name" value="Endochitinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF79">
        <property type="entry name" value="CHITINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00774">
        <property type="entry name" value="CHITINASE_19_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 9" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6 8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159720" evidence="10">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8 9">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8 9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8 9">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8 9">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="95"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="332" mass="35527" checksum="1963CD88C06BBB24" modified="2016-04-13" version="1">MDKFLVLTILVFLFLATAVSAQDCGRQGGNRPCTNGNCCSQYGFCGNTPAHCSPENNCQSQCTGGGGGGGGGGGASIVTASAFDQMLKYRNDPRCSANGFYTYNAXVVAAAVVLLPSLLHLRLTKCSNAAKAYSGFGTTGSADDRKRELAAFFAQTSHETTGGWASAPDGPYAWGYCFVRERDQSNSYCDSNAWPCPQKYFGRGPIQLSHNYNYGEFGKSIGRDLINNPDLLATDPTLSFRSAIWYWMTPQGNKPSSHDVITGRWTPSAADSSAGRVPGLGVITNIINGGLECGHGQDNRVADRIGFHTRYCQILGVSPGNNLDCYNQRPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVZ1</accession>
    <name>A0A118JVZ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004789">
        <property type="protein sequence ID" value="KVH93250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVZ1"/>
    <dbReference type="Gramene" id="KVH93250">
        <property type="protein sequence ID" value="KVH93250"/>
        <property type="gene ID" value="Ccrd_004703"/>
    </dbReference>
    <dbReference type="OMA" id="CEGETTW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054:SF20">
        <property type="entry name" value="DUF547 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ternary complex factor MIP1 leucine-zipper" evidence="3">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="319"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61783" checksum="0B2E3638C5FD97A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW90</accession>
    <name>A0A118JW90_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004622">
        <property type="protein sequence ID" value="KVH93700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW90"/>
    <dbReference type="STRING" id="59895.A0A118JW90"/>
    <dbReference type="Gramene" id="KVH93700">
        <property type="protein sequence ID" value="KVH93700"/>
        <property type="gene ID" value="Ccrd_004247"/>
    </dbReference>
    <dbReference type="OMA" id="WQERRQI"/>
    <dbReference type="OrthoDB" id="783725at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF7">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AUX/IAA" evidence="2">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18683" checksum="8B8033C53674FD9D" modified="2016-04-13" version="1">MNSGDQNGSLSMMKRRWLQEHQRRLMSQPYVNMFLSSPPPPPAPPIHKFLKEEDDLIAGVIPAVTVVVEGRSICHRINLHNHDGYNSLAKALRYMLVDDSCNDNDDEKGVIDLSNAVPGHIIAYQDLENDLLLAGDLNWKDFIRVARRIRIIPVKGNSSKGKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXX7</accession>
    <name>A0A118JXX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004023">
        <property type="protein sequence ID" value="KVH96937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXX7"/>
    <dbReference type="STRING" id="59895.A0A118JXX7"/>
    <dbReference type="Gramene" id="KVH96937">
        <property type="protein sequence ID" value="KVH96937"/>
        <property type="gene ID" value="Ccrd_000970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF9">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="69" mass="7265" checksum="FE4C031924E72B94" modified="2016-04-13" version="1">MTIDVADTVGYCLPREFGQLVADIKANTPGLENVGISSGATQVDVTINGIEERAGNASLEEVSIILQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY74</accession>
    <name>A0A118JY74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP2/ERF transcription factor family. RAV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003824">
        <property type="protein sequence ID" value="KVH97616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY74"/>
    <dbReference type="STRING" id="59895.A0A118JY74"/>
    <dbReference type="Gramene" id="KVH97616">
        <property type="protein sequence ID" value="KVH97616"/>
        <property type="gene ID" value="Ccrd_000315"/>
    </dbReference>
    <dbReference type="OMA" id="QLYIVWK"/>
    <dbReference type="OrthoDB" id="2020802at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000008">
        <property type="entry name" value="AP2 domain-containing protein RAP2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044800">
        <property type="entry name" value="LEC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR ABI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140:SF112">
        <property type="entry name" value="ETHYLENE RESPONSE DNA BINDING FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="9">
        <location>
            <begin position="183"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="39175" checksum="16073567B15D6166" modified="2016-04-13" version="1">MDRNCTDDQSTTSETTSTLAPPVSTPEMISLCRVGSGASMVLDPEGGLEAQSRKLPSSRFKGVVPQPNGRWGAQIYEKHQRVWLGTFNEEDEAAKAYDVAVQRFRGRDAVTNFKPLVADTKEASLEASFLSSHSKAEIVDMLRKHTYNDELEQSKRNCNLDKTSSRDGGCSGSGVVKPREHLFQKTVTPSDVGKLNRLVIPKQHAEKHFPVQRGSTSKGVLLHFEDSDAKVWRFRYSYWNSSQSYVLTKGWSRFVKEKNLKAGDTVNFQSSTGLNKQLYIDWKSKSGSGNTDPQAIQVQPATKCVEPVQMLRLFGVNIKSVSSCNGNRRSNTEMDLLGFQSCKKQRIIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZL0</accession>
    <name>A0A118JZL0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone deacetylase interacting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003609">
        <property type="protein sequence ID" value="KVH99339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZL0"/>
    <dbReference type="Gramene" id="KVH99339">
        <property type="protein sequence ID" value="KVH99339"/>
        <property type="gene ID" value="Ccrd_022432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="11072" checksum="1B4F19A11CB9EF4F" modified="2016-04-13" version="1">MWVFDVATRQARLLIKSKIFSSSMFIAFQEVRNSHEGSQSSFQKKYQEKLSEFEDKRYEIDMALECVKLTIRWLKSMALVTGGLKALSWNLCSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K054</accession>
    <name>A0A118K054_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003161">
        <property type="protein sequence ID" value="KVI00948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K054"/>
    <dbReference type="STRING" id="59895.A0A118K054"/>
    <dbReference type="Gramene" id="KVI00948">
        <property type="protein sequence ID" value="KVI00948"/>
        <property type="gene ID" value="Ccrd_020790"/>
    </dbReference>
    <dbReference type="OMA" id="CHPRSTV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000452">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase RFK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000433">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF72">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RFK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159849" evidence="3">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="33428" checksum="6523C272FBB29369" modified="2016-04-13" version="1" fragment="single">MPLEKMMSKVGYVLFLALNLIILVRVSDSVVPEEEVEALQEIMELMGTTNWRLNGKSCQLEVISEVQKPHPEADARVECDINCNNGNSSNCHVVSITHKYYSLGGVLPPDLVKLPHLHTIDFAFNYLGGTIPSELGSIPLQSISLLGNRFSGEIPGELGNITTLTYLNLEANNFSGTVPSELGRLINLQALILSSNRLTGTLPASFAELRNLKDFRISDNNFSGSIPNFIQNWRQISKLEMIGTGLQGPIPSNISLLQDLTDLRICEVSGSTQGFPSLDSATNLQTVVLRSCNISGEIPAYIWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0C4</accession>
    <name>A0A118K0C4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_020477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003122">
        <property type="protein sequence ID" value="KVI01260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0C4"/>
    <dbReference type="STRING" id="59895.A0A118K0C4"/>
    <dbReference type="Gramene" id="KVI01260">
        <property type="protein sequence ID" value="KVI01260"/>
        <property type="gene ID" value="Ccrd_020477"/>
    </dbReference>
    <dbReference type="OMA" id="WSIHTRR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010078">
        <property type="term" value="P:maintenance of root meristem identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000664">
        <property type="entry name" value="Cyclin-dependent kinase F-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI01260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="473" mass="52724" checksum="938B0C24DBCA14B8" modified="2016-04-13" version="1">MDPIPPSTTKSWSIHTRREITSKYEIQTRVGSGAYSDVYKARRLSDDLPVALKEVHDYQSAFREIEALQTLQHSPNVVVLHEYFWSEDEDAVLVLEYLPTDLSSVIRMAKKEREGLSVGEIKRWIIQILLAVDACHRSSIIHRDLKPSNLLISADGVLKLADFGQARIRLAPGFVSINDHTQPQGHESSVYQQVKPENVGQESRVNLMEGPLGTIEEYGTSDEFKTKDTFDEVDKETNIPDVDTSCLATCTTSDVEEDFFKSNYSYEANEAGGNDESALLTSCVGTRWFRAPELLFGSTNYGAEIDLWSLGCIIAELFTLEPVFPGSSDIDQLSRIFTVLGNLSEEVWPGCVQLPDFRIISFSKVENPSGLDSCLPNRSQDEILLAKKLLCFDPAGRATAMELLHDKYLNEEPLPVPVSELRVPSSNHGEDNGSSGSGEWGDHREMDSDSDFDDFGGFDITRRTGGDFSIQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1A5</accession>
    <name>A0A118K1A5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1A5"/>
    <dbReference type="STRING" id="59895.A0A118K1A5"/>
    <dbReference type="Gramene" id="KVI02565">
        <property type="protein sequence ID" value="KVI02565"/>
        <property type="gene ID" value="Ccrd_019151"/>
    </dbReference>
    <dbReference type="OMA" id="VNWFAIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF12">
        <property type="entry name" value="CASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="8">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="8">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17084" checksum="86216FF84EA55EE6" modified="2016-04-13" version="1">MMKLGVAPPANRGIGILDFILRLIAITGTLAGAIAMATTNQTLPFFSRFVRFRAKFDDLPSFAFFVVASSIVSVYLILSLAFSVLHIVKANAVNSRVLLLFLDTLAHEGNNKVNWFAICVQYNSFCKRVSGSLIGSYAGVLMLILLILLSGVALSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2B7</accession>
    <name>A0A118K2B7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002310">
        <property type="protein sequence ID" value="KVI04097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2B7"/>
    <dbReference type="STRING" id="59895.A0A118K2B7"/>
    <dbReference type="Gramene" id="KVI04097">
        <property type="protein sequence ID" value="KVI04097"/>
        <property type="gene ID" value="Ccrd_017601"/>
    </dbReference>
    <dbReference type="OMA" id="TLIKFAC"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000543">
        <property type="entry name" value="Armadillo repeat only 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056694">
        <property type="entry name" value="DUF7792"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46168:SF8">
        <property type="entry name" value="ARMADILLO REPEAT ONLY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46168">
        <property type="entry name" value="ARMADILLO REPEAT ONLY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25055">
        <property type="entry name" value="DUF7792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7792" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI04097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="648" mass="72560" checksum="E05DC2131AE92E1E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2H5</accession>
    <name>A0A118K2H5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002191">
        <property type="protein sequence ID" value="KVI04380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2H5"/>
    <dbReference type="Gramene" id="KVI04380">
        <property type="protein sequence ID" value="KVI04380"/>
        <property type="gene ID" value="Ccrd_017308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="129" mass="14608" checksum="DA1146296987670C" modified="2016-04-13" version="1">MEGFISLLQHQDNKENIPPFSKTHDNKLSPKMTLKKKKKTNYRKPLNDITNLLLYSPIHPPETSPSFPRLQSAAICRSKAAETLSNHVICDTIISVSHQFVSRLMLRISLTLQASSFAQHLLPIVSLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3B5</accession>
    <name>A0A118K3B5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001863">
        <property type="protein sequence ID" value="KVI05683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3B5"/>
    <dbReference type="STRING" id="59895.A0A118K3B5"/>
    <dbReference type="Gramene" id="KVI05683">
        <property type="protein sequence ID" value="KVI05683"/>
        <property type="gene ID" value="Ccrd_015984"/>
    </dbReference>
    <dbReference type="OMA" id="KNGFMSV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010405">
        <property type="term" value="P:arabinogalactan protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF42">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159932" description="alpha-galactosidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="8">
        <location>
            <begin position="456"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="538" mass="60274" checksum="FAE2243AD0F67775" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4A6</accession>
    <name>A0A118K4A6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001510">
        <property type="protein sequence ID" value="KVI07198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4A6"/>
    <dbReference type="Gramene" id="KVI07198">
        <property type="protein sequence ID" value="KVI07198"/>
        <property type="gene ID" value="Ccrd_014433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="25923" checksum="A9D7A8FC62855DBF" modified="2016-04-13" version="1">MEISGQATIGEEEYTPFDFNFFLVVYSFGNSLQQLDKDRSVDELEIFLEAVNGEGFSNKTSEALVVFTVLLKQTIGAQHLLTGVEQIDYLCCLLFMKLKIPAGLENSDMKDKLSPTNGQPRLPGMPSISFGKALARSKARVRISSSRTNPTPITIAMLTSISLVPSDSLYNVAVSRHFQVDNISPSYARNIHLEHKNQGKEPKNNVLAILSGPYSQPSSPKVLPSPLPAMVHRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4N4</accession>
    <name>A0A118K4N4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gibberellin regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001488">
        <property type="protein sequence ID" value="KVI07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4N4"/>
    <dbReference type="STRING" id="59895.A0A118K4N4"/>
    <dbReference type="Gramene" id="KVI07785">
        <property type="protein sequence ID" value="KVI07785"/>
        <property type="gene ID" value="Ccrd_013855"/>
    </dbReference>
    <dbReference type="OMA" id="DFVHADM"/>
    <dbReference type="OrthoDB" id="625265at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF2">
        <property type="entry name" value="GIBBERELLIN-REGULATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159958" evidence="2">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="96" mass="10320" checksum="81C533A529E91306" modified="2016-04-13" version="1">MAISKPFLALVLLSMLLLVQATELVDGSDRKHGFKINCGAACKARCRLSSRPNLCHRACGTCCARCSCVPPGTSGNQKVCPCYYNMTTHGGKRKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5J0</accession>
    <name>A0A118K5J0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5J0"/>
    <dbReference type="STRING" id="59895.A0A118K5J0"/>
    <dbReference type="Gramene" id="KVI09183">
        <property type="protein sequence ID" value="KVI09183"/>
        <property type="gene ID" value="Ccrd_012426"/>
    </dbReference>
    <dbReference type="OMA" id="WLACTHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000061">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="124"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="217"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="42779" checksum="4489C028E12E4971" modified="2016-04-13" version="1" fragment="single">YRDSAYHTWLACTHYLRGVRDVYNYLTVTDNRLLSVLPSSQFTTIPHRAPAPAPAMALAMKRAAATAVRAISSANSASILTRQLHASAEKKKIVGVFYKAHEYAEMNPNFLGCAENALGIRNWLESQGHEYIVTDDKEGPDCELEKHISDMHVLITTPFHPAYVTAERIKKAKNLQLLLTAGIGSDHVDLQAAAAAGLTVAEVTGSNVVSVAEDELMRILILVRNFLPGHHQVISGDWNVAGIAYRAYDLEGKTVGTVGCGRIGRLLLQRLKPFGCNLLYHDRIKMDQELENQIGAKFEEDLDKMLPKWYSGDVWYPQPAPKDHPWRYMPNQAMTPHISGTTIDAQLRYAAGVKDMLENYFKGEDFPAQHYIVKEGELASQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6X8</accession>
    <name>A0A118K6X8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000184">
        <property type="protein sequence ID" value="KVI11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6X8"/>
    <dbReference type="STRING" id="59895.A0A118K6X8"/>
    <dbReference type="Gramene" id="KVI11400">
        <property type="protein sequence ID" value="KVI11400"/>
        <property type="gene ID" value="Ccrd_010191"/>
    </dbReference>
    <dbReference type="OMA" id="RIYRYNH"/>
    <dbReference type="OrthoDB" id="1523082at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34945">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34945:SF6">
        <property type="entry name" value="GIBBERELLIN 2-BETA-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38143" checksum="AF31CB1070E728CE" modified="2016-04-13" version="1">MAIARIRSRLSSSAASQPPSPMPNSRTTSRSDPAFNNYVDKLKNIPEFDLPDDLNRPTIADLEYRLIKSKDKKSIQEMLDSAAKYGVFKVSGHGISAEDLQDAFTEAEFCFGLLAERWSRDGDREEFAWSRSAMAVAERRREVKSEEQFQKFRKKMENVANKLEVIANDVTQIMGNNSAKQPRKKIKENETKMTLFKHSNSSLQPHTPRSSHTPRALDGSRRDSSAFAISLHIPTEAGEFRLLSEGGPYSFGTNPSTIVFTVGEQLEEWSYGEFRSAFGEINIEPDIQDEKGAFSIELKCSPSNLNDAVDKHDTISITDQIIFVVIVAILYKLFSFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7B8</accession>
    <name>A0A118K7B8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitogen-activated protein (MAP) kinase, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000020">
        <property type="protein sequence ID" value="KVI12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7B8"/>
    <dbReference type="STRING" id="59895.A0A118K7B8"/>
    <dbReference type="Gramene" id="KVI12015">
        <property type="protein sequence ID" value="KVI12015"/>
        <property type="gene ID" value="Ccrd_009574"/>
    </dbReference>
    <dbReference type="OMA" id="RVIMSLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010225">
        <property type="term" value="P:response to UV-C"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07858">
        <property type="entry name" value="STKc_TEY_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="44918" checksum="17115BF944DDBBCC" modified="2016-04-13" version="1">MEGDDSKGEGLVLKGVPAYGGKYIHYSVLGNLFEVSSKYVPPIQPVGRGAYGIVCRGRVAVPMQRGRPWISKEVSCAKNSETKEEVAIKKIGNAFDNNIDAKRTLREIKLLCHMDHENIVKIKDIIRPPDKEKFNDVYIVYELMDTDLHQIIRSSQALTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDFMTEYVVTRWYRAPELLLNCSEYTTAIDIWSVGCILMEIILREPLFPGKDYVQQLVLITELLGSPDDADLGFLRSDNARRYVKQLPHVPTNTFQQKFPKVSPVVIDLAEKMLVFDPSKRISVEDALNHPFLQSLHEINEEPTCSSPFVFDFEQASLSEEDVKELIWKETLTFNPDSVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAQ1</accession>
    <name>A0A124SAQ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005534">
        <property type="protein sequence ID" value="KVH88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAQ1"/>
    <dbReference type="STRING" id="59895.A0A124SAQ1"/>
    <dbReference type="Gramene" id="KVH88181">
        <property type="protein sequence ID" value="KVH88181"/>
        <property type="gene ID" value="Ccrd_024428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="285" mass="32632" checksum="8A0CB1CA00400172" modified="2016-04-13" version="1">MALEWGLHAEGARESSSRVWIADVFSVRPTLISETSALRALRCPSMLVFILEKDSCTNLTKDFCTNLTFDIMDSTLISIVSKVGSISLTSTVMSYSLVEGFSMKVHVKGEENVVVPRINVEYVLNDVMRIIVDLLRFLTRSALSHKDEIKLLEKLNMLLIPQNQIANLAEMKNQWWQEIEVRLTTVAAKKPRWNSALRAVAMVGRRWLLTMCEDHLLVRQLTRYADEPRLKLPIQIEASRRAMTRNARRGGKIWVHMFPDKPVTKNTKEELIPFTSNPLYLMKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBI1</accession>
    <name>A0A124SBI1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">No apical meristem (NAM) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBI1"/>
    <dbReference type="STRING" id="59895.A0A124SBI1"/>
    <dbReference type="Gramene" id="KVH90701">
        <property type="protein sequence ID" value="KVH90701"/>
        <property type="gene ID" value="Ccrd_007333"/>
    </dbReference>
    <dbReference type="OMA" id="FSINNHH"/>
    <dbReference type="OrthoDB" id="1424968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000006">
        <property type="entry name" value="NAC domain-containing protein 100-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF213">
        <property type="entry name" value="NAC DOMAIN CONTAINING PROTEIN 46-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="407" mass="46054" checksum="9BE33C0C97EE2AB2" modified="2016-04-13" version="1">MEGGTMVVNEGDDALIGLPPGFRFHPTDEEIITHYLTPKVVNRSFTASAIGEVDLNKCEPWDLPRKAKMGEKEWFFFCQRDRKYPTGMRTNRATDSGYWKATGKDKEILKKGKSGGRLVGMKKTLVFYKGRAPKGEKTNWVMHEFRLEGDFSYYNMSRASKDEWVVCRVVQKNTEMKRNPISDSGMTRMNSFVDELLDSPPWLPPLMDPPAPHFDPDRAGSSFTSSDKIITNNHTENSSVQKFKGLVDHENCPSYFSHDQSQMLQRDQDYKNFLVSPYNYNFDTNSYQMSPFISDHQLSTHPNFASTLANNFPYLSSPGSTRYMDQASGLEGEAEKVGGQCKVEPYVTSTNQSSKISVTSQDTGVSNDITTEISSSSKHDMSMRPYDHPDDQTTPSVLSELDSLLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBN6</accession>
    <name>A0A124SBN6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome, beta-type subunit, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005070">
        <property type="protein sequence ID" value="KVH91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBN6"/>
    <dbReference type="STRING" id="59895.A0A124SBN6"/>
    <dbReference type="Gramene" id="KVH91195">
        <property type="protein sequence ID" value="KVH91195"/>
        <property type="gene ID" value="Ccrd_006789"/>
    </dbReference>
    <dbReference type="OMA" id="QYQRRHL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="176" mass="19476" checksum="5485F15EA35C83DC" modified="2016-04-13" version="1">MPKEHANWSPYDNNGGTCVAIAGADYCVIAADTRMSTGYSILTRDYSKICKLADKSFMASSGFQADVKALQKVLASRHLIYQHQHNKQMSCPAMAQLLSNTLYYKRFFPYYAFNVLGGLDSEGKGCVFTYDAVGSYERDAVTPLSEAEAIDLGDSVEIVILNAHGVRSEHEQLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCA9</accession>
    <name>A0A124SCA9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the plant dehydrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004791">
        <property type="protein sequence ID" value="KVH93221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCA9"/>
    <dbReference type="STRING" id="59895.A0A124SCA9"/>
    <dbReference type="Gramene" id="KVH93221">
        <property type="protein sequence ID" value="KVH93221"/>
        <property type="gene ID" value="Ccrd_004741"/>
    </dbReference>
    <dbReference type="OMA" id="QHHGSLE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009631">
        <property type="term" value="P:cold acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000167">
        <property type="entry name" value="Dehydrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030513">
        <property type="entry name" value="Dehydrin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33346:SF5">
        <property type="entry name" value="DEHYDRIN LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33346">
        <property type="entry name" value="DEHYDRIN XERO 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00257">
        <property type="entry name" value="Dehydrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00823">
        <property type="entry name" value="DEHYDRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="207" mass="21399" checksum="95A8EDED7B0F4DA0" modified="2016-04-13" version="1">MADIRDERGNPVQLTDERGNPVQLTDERGVPIHLSGVATATTHGGTTIGSELHDKTWHDHATLGSKTHGGTYFAPTPVDYAKRGGEAIASAGAATMGVAGGDGKAATGSVTGGGAPVSHTQAHGAGEHEKQLERSSSSSSRGRRKKKGLKEKIKEKLPGHGEKAAHSRDTRASSVTTGAGATATAGEQHQEKKGLMDKIKDKLPGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCJ5</accession>
    <name>A0A124SCJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2, LYAR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCJ5"/>
    <dbReference type="STRING" id="59895.A0A124SCJ5"/>
    <dbReference type="Gramene" id="KVH93997">
        <property type="protein sequence ID" value="KVH93997"/>
        <property type="gene ID" value="Ccrd_003950"/>
    </dbReference>
    <dbReference type="OMA" id="QNWIKNS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001583">
        <property type="entry name" value="UBP1-associated proteins 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="38593" checksum="1E664B8FD6043607" modified="2016-04-13" version="1">MVWFQCEDCGDNLKKPKLANHFRVCSANKLSCIDCGQMFGQQSVQGHTQCITETEKYGPKGQAKPSTPGKPNSSSKPKPEVDINVGLSERPPWFCSLCNTSATSKQTLLLHADGKKHRAKARAFHASQQPPKVSEEPTPNTEGKSENIQKNDSEDVKETLTSENKKRKLESSENNGASHTPGGNAAGELGNGEVIQDANTESEKPKKAKRKEEDGQKRIKWKKIITAVLNSNPDGILKMRKLRAQVLKTLTESGSKIDENQLVDTLEHKINSSSKFTVNGKYVQLLKPEVLCKIPQELHIVEGEHPCLIGLAFVYLHAKAEAEAAAAAAAAAATLPVPVQYLKSAIRTVGSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFB5</accession>
    <name>A0A124SFB5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GNS1/SUR4 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002648">
        <property type="protein sequence ID" value="KVI02641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFB5"/>
    <dbReference type="STRING" id="59895.A0A124SFB5"/>
    <dbReference type="Gramene" id="KVI02641">
        <property type="protein sequence ID" value="KVI02641"/>
        <property type="gene ID" value="Ccrd_019077"/>
    </dbReference>
    <dbReference type="OMA" id="QSILLCM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF11">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="303" mass="34991" checksum="E7C58EF2C5F84547" modified="2016-04-13" version="1">MYYLSEHPSIVNFRWNHTQSWGSTWSFLFTSISAYILLSLLLNLLLFNRRRPVPLGPIPAIHSLSMALISATIFTGILFSAAAEIRDTRWFWRRNKTTAFQWLLCFPLGTRPSGRVFFWSYIFYLTRFLHTLRTFIAILRRRKLSFFRLFNHSILIIMSFLWLEFSQSFQILAILFTTSIYSIVYGYRFWTAIGLRSACFPFVINCQMVLLGCNLICHIGVLLLHLMKGGCNGIGAWGFNSVLNFAILFLFLNFYVKSHLRKKTKTSRSSSEYGDDEGLNLKSDSSTAIMDLNPIGCTKIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFG5</accession>
    <name>A0A124SFG5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic</fullName>
            <ecNumber evidence="16">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbamoyl phosphate synthase pyrimidine-specific large chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_018539</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of the biosynthetic pathway leading to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="16"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002441">
        <property type="protein sequence ID" value="KVI03166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFG5"/>
    <dbReference type="STRING" id="59895.A0A124SFG5"/>
    <dbReference type="Gramene" id="KVI03166">
        <property type="protein sequence ID" value="KVI03166"/>
        <property type="gene ID" value="Ccrd_018539"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000007">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000013">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="23">
        <location>
            <begin position="194"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="23">
        <location>
            <begin position="729"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="24">
        <location>
            <begin position="965"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVI03166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1157" mass="128043" checksum="8B8EF028601393D3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHQ0</accession>
    <name>A0A124SHQ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHQ0"/>
    <dbReference type="STRING" id="59895.A0A124SHQ0"/>
    <dbReference type="Gramene" id="KVI10246">
        <property type="protein sequence ID" value="KVI10246"/>
        <property type="gene ID" value="Ccrd_011352"/>
    </dbReference>
    <dbReference type="OMA" id="QPNMAES"/>
    <dbReference type="OrthoDB" id="2020166at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080117">
        <property type="term" value="P:secondary growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF58">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="180" mass="19567" checksum="B5FCDABBD13986A3" modified="2016-04-13" version="1">MKDSGSSGGGAGRKQGAASPCAACKLLRRRCSQDCVFAPYFPADEPQKFASVHKVFGASNVNKMLQELPEHHRGDAVSSMVYEANARIRDPVYGCVGAISSLQQQIDVLQAQLAVSQAEVVHMRMRQFSSSPVNQSPENISPPSRHHPSHTPTRSLFGMDMVVDHQSHMGMGESLWSSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SIB8</accession>
    <name>A0A124SIB8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_009353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SIB8"/>
    <dbReference type="STRING" id="59895.A0A124SIB8"/>
    <dbReference type="Gramene" id="KVI12213">
        <property type="protein sequence ID" value="KVI12213"/>
        <property type="gene ID" value="Ccrd_009353"/>
    </dbReference>
    <dbReference type="OMA" id="WDEVCES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="101"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="364"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="394"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="601" mass="66966" checksum="59286BD738030A86" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5H6</accession>
    <name>A0A103D5H6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_024308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01012760">
        <property type="protein sequence ID" value="KVD98099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5H6"/>
    <dbReference type="Gramene" id="KVD98099">
        <property type="protein sequence ID" value="KVD98099"/>
        <property type="gene ID" value="Ccrd_024308"/>
    </dbReference>
    <dbReference type="OMA" id="HFRYSDL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000489">
        <property type="entry name" value="Inactive receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46084:SF19">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46084">
        <property type="entry name" value="PROTEIN MALE DISCOVERER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="52"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVD98099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="36442" checksum="BAF6BE3F63619753" modified="2016-04-13" version="1" fragment="single">MAIYIGEKIFIKNFGFYVDCIQNRDFFLHYADSDLLKDVTRYSRQELEVACEDFSNIIGSSSDSVVYKGTMKGGPEIAVISLCNQEEHWTAYLELYFQKEVADLARLNHENIGKLMGYCVEATPLTRMLVFDYASNGTLSEHLHCEEGCQLSWTRRMMIVIGLAKGLKYLHTEIEPPFTISELNSSAIYLTEDFLPKLVDFESWKTILTRSGNNFRSIGSEGAAMCVQPSSLEERHLDVEGNIYAFGVLLLEIVSGRPPVCKDKGVLVDWAKDYLEEPEKMALIVDPALKHFRDEDLEAIREVVAICIHLRPRDKVNMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103EQS1</accession>
    <name>A0A103EQS1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01010782">
        <property type="protein sequence ID" value="KVE39115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103EQS1"/>
    <dbReference type="Gramene" id="KVE39115">
        <property type="protein sequence ID" value="KVE39115"/>
        <property type="gene ID" value="Ccrd_023989"/>
    </dbReference>
    <dbReference type="OMA" id="FMECAER"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000027">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000065">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1417">
        <property type="entry name" value="UDP-GLUCURONOSYL_UDP-GLUCOSYLTRANSFERASE, UDP-GLYCOSYLTRANSFERASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVE39115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="480" mass="54306" checksum="C9E89296F473FEDB" modified="2016-04-13" version="1">MTETMATAEKKPHVIFIPFPAQSHVKAMLKLAELLHHKGLRITFVNTEFVHKRLLKSAGPHYLSASPDFHLETIPDGIPRTSEDDNDSDLLLHYLETNFLAPFLELATKLPTPPTCIISDGLMSSFPIDAAQTLEIPIMLYWTLSACGFMGLYQIQSLIDKGLTPVQDESYLTNGFLETIIDWIPGMKSIRLKDLPTNVWTTDPNDKGYRFLIQATKNSNKVSNIILHTFDELEDSIVKALSSMFHHVYTIGPVQLLLDQTTEHAETPNVNGYSLWKEEPDCFKWLESKEPNSVIYVNYGSTTVMSLEELIEFGWGLADSNHYFLWILRSNLVVGDQSAVLPPELEEQIKRRGFIASWCSQEKVLNHTSIGGFLTHGGWGSTIESLSAGVPMICWPYLWDQTTNCRFICKEWDVGLEMGKNVKRDEVKKLVQELMGEGGQRMRNKAMEWKEKAKMATSPNGSSFLNVEKLVKEITMLSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103L9F4</accession>
    <name>A0A103L9F4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009117">
        <property type="protein sequence ID" value="KVF71647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103L9F4"/>
    <dbReference type="Gramene" id="KVF71647">
        <property type="protein sequence ID" value="KVF71647"/>
        <property type="gene ID" value="Ccrd_026706"/>
    </dbReference>
    <dbReference type="OMA" id="FETISHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004:SF439">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVF71647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="640" mass="70825" checksum="244B808ECDDDCEA5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBX5</accession>
    <name>A0A103XBX5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Target SNARE coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_024783</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the BET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005728">
        <property type="protein sequence ID" value="KVH87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBX5"/>
    <dbReference type="STRING" id="59895.A0A103XBX5"/>
    <dbReference type="Gramene" id="KVH87903">
        <property type="protein sequence ID" value="KVH87903"/>
        <property type="gene ID" value="Ccrd_024783"/>
    </dbReference>
    <dbReference type="OMA" id="ANSHRVG"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000056">
        <property type="entry name" value="Bet1-like protein At4g14600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14952" checksum="41F2F26304FC8981" modified="2016-04-13" version="1">MASSSNKGGGYYGAAPYRSREGLSARQGNSSDEIQLQIDPMHADLDDEISGLRKQVRQLKNVASEIESEAKFQNEFINQLQMTLIKAQAGVKNNMRKLNKSIIQSGSSHVLHVVLFALFCLFLVYLWSKFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC28</accession>
    <name>A0A103XC28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005662">
        <property type="protein sequence ID" value="KVH87966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC28"/>
    <dbReference type="Gramene" id="KVH87966">
        <property type="protein sequence ID" value="KVH87966"/>
        <property type="gene ID" value="Ccrd_024648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="14474" checksum="F8841517EAB1A728" modified="2016-04-13" version="1">MGRQESPHIGPSIHGFSRQKRSNGIDKKAGSLFGALRNDQLRGFVIINGDFEQIFKVTTFRLYRFDPFQPPCEALITNHMDPILFVLEVNLQVKTSSVLFPDLGCITNSNSSGASCYWGDDANEHISRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCF3</accession>
    <name>A0A103XCF3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005539">
        <property type="protein sequence ID" value="KVH88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCF3"/>
    <dbReference type="STRING" id="59895.A0A103XCF3"/>
    <dbReference type="Gramene" id="KVH88170">
        <property type="protein sequence ID" value="KVH88170"/>
        <property type="gene ID" value="Ccrd_024441"/>
    </dbReference>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118684" evidence="4">
        <location>
            <begin position="22"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="401"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="646" mass="72736" checksum="C43B68CDB5309103" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGB6</accession>
    <name>A0A103XGB6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGB6"/>
    <dbReference type="STRING" id="59895.A0A103XGB6"/>
    <dbReference type="Gramene" id="KVH90210">
        <property type="protein sequence ID" value="KVH90210"/>
        <property type="gene ID" value="Ccrd_007783"/>
    </dbReference>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="180" mass="20185" checksum="7EA0898626432E8C" modified="2016-04-13" version="1">MATSASPQQPGGAVVAERRGIPAASFVEDVQIYLNQLGLDVNSTLAFLQERLQQYKVVEMKLLAQQRDLQAKIPDIEKCLDALLTDFEASEGIYSRARVEDIDSVCLWLGANVMLEYSCEEATSLLRKNLENAKASLEVLIADLQFLRDQVTITQVTIARVYNWDVHQRRVRQALASQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGM6</accession>
    <name>A0A103XGM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005106">
        <property type="protein sequence ID" value="KVH90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGM6"/>
    <dbReference type="STRING" id="59895.A0A103XGM6"/>
    <dbReference type="Gramene" id="KVH90334">
        <property type="protein sequence ID" value="KVH90334"/>
        <property type="gene ID" value="Ccrd_007657"/>
    </dbReference>
    <dbReference type="OMA" id="LHITHFH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043459">
        <property type="entry name" value="NFD6/NOXY2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156">
        <property type="entry name" value="OS02G0230000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156:SF39">
        <property type="entry name" value="PROTEIN NONRESPONDING TO OXYLIPINS 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="12213" checksum="AFBAC9B2C0B69153" modified="2016-04-13" version="1">MLRQSPLKPFTPFVTLTVLPSTAMASRYRSISRPASILFKSMSTPSPKPTSIPSLAPRSSSTTTVSRSFSRIGCVQSLLPLHTAVSSARLTSCLGIDSKGSRSLSQGMLSSANPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIC9</accession>
    <name>A0A103XIC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005044">
        <property type="protein sequence ID" value="KVH91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIC9"/>
    <dbReference type="STRING" id="59895.A0A103XIC9"/>
    <dbReference type="Gramene" id="KVH91351">
        <property type="protein sequence ID" value="KVH91351"/>
        <property type="gene ID" value="Ccrd_006634"/>
    </dbReference>
    <dbReference type="OMA" id="WKSKTYS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009657">
        <property type="term" value="P:plastid organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd13661">
        <property type="entry name" value="PBP2_PotD_PotF_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30222">
        <property type="entry name" value="SPERMIDINE/PUTRESCINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30222:SF17">
        <property type="entry name" value="SPERMIDINE_PUTRESCINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="410" mass="45411" checksum="F9ED8AB153457245" modified="2016-04-13" version="1">MHVSLVNIDSSSGEYENEEVKAAFESYKSKTYALTVPLRIVALRSSVPPLWIKNFIQSQGRRVKFRLEFRGTLEGIFSELSTTIGKGKVSSKLAGAADIISLGDTWVNFAISKKLIEPIQGVDEQDWFCKLSDKWKVYLRRNDEGKSDTEGKIWAVPYRWGSMVIAYRKNKFRQHNLAPIEVIGAVLKYLGASYNTSNIDSQVTGGRNAVKDELAALQKQVRLFDSANYLKAFNVGDVWVAVGWSSDIVPAAKRMSDVAVIVPKSGASLWADLWAIPAASGIATDELGGRIRGPSPLVHQWIDFCLQSQRAIPFEEEIVAGASPSAFDNTPLPKSKNLSKNKPKLDTNLIAGGVPPPEILTRCEFLEPLSDSASLDHQWLISSMQNPNHGFMHKLQHCILWASNALQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ07</accession>
    <name>A0A103XJ07_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004928">
        <property type="protein sequence ID" value="KVH91538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ07"/>
    <dbReference type="Gramene" id="KVH91538">
        <property type="protein sequence ID" value="KVH91538"/>
        <property type="gene ID" value="Ccrd_006437"/>
    </dbReference>
    <dbReference type="OMA" id="RVPQWSH"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12203">
        <property type="entry name" value="GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654">
        <property type="entry name" value="FI21293P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654:SF84">
        <property type="entry name" value="SI:DKEY-66I24.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="319" mass="37543" checksum="B646E39AAD35D2A8" modified="2016-04-13" version="1">MFRSTSGGGGGGGGRDNNESLAGLTQMMMMNVPPRQPAMVVGGGADAEDFLRRDDRVPSWSQQETRDFIAIRGELERDFTTAKRNKSLWEVVAAKMKEIGYRRTPDQCKCKWKNLVNRYKGKETLDRENSRSFPFFDEMHALFTERTSNTPPTPFDPEATSSHSKKRGIKMDSYQSLEELSEDEDEYEDEEIKIAKATVPPRKKPEREKRARTSSLDKPPTPKQPSSGNNSIREILHDFFQQQEMIETQWRQLMEKHDYERRVFDQEWRQSMERLEMERMRIEQSWREKEEQRRMREESRAERRDALLTALLNKLVHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJS8</accession>
    <name>A0A103XJS8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major sperm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004895">
        <property type="protein sequence ID" value="KVH91973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJS8"/>
    <dbReference type="STRING" id="59895.A0A103XJS8"/>
    <dbReference type="Gramene" id="KVH91973">
        <property type="protein sequence ID" value="KVH91973"/>
        <property type="gene ID" value="Ccrd_005990"/>
    </dbReference>
    <dbReference type="OMA" id="AENAKPH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF42">
        <property type="entry name" value="VESICLE-ASSOCIATED PROTEIN 2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25387" checksum="370B5B5505CD8A05" modified="2016-04-13" version="1">MTSGGGNNLISVDPEELRFQFELEKPMHCDIKVTNTTDKHVAFKVKTTSPKKYFVRPNTGVIQPRDICTIRVTLQAQVEYPPDMQCKDKFLLQSTLVPANTDTEELPQNTFSKEPGKQLEECKLKVCYVARTDQGNSDDNLKQNSDPSSTARAARDSAVREVTQLQQELDMLKKRRQRSKASPGFSLRLAIAAGLIGIMVGFVLKLALSSPPPPPPPTPTPTPPPATAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK47</accession>
    <name>A0A103XK47_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">inositol-1,3,4-trisphosphate 5/6-kinase</fullName>
            <ecNumber evidence="4">2.7.1.159</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.159" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004840">
        <property type="protein sequence ID" value="KVH92164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK47"/>
    <dbReference type="STRING" id="59895.A0A103XK47"/>
    <dbReference type="Gramene" id="KVH92164">
        <property type="protein sequence ID" value="KVH92164"/>
        <property type="gene ID" value="Ccrd_005800"/>
    </dbReference>
    <dbReference type="OMA" id="IYMEKFE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010264">
        <property type="term" value="P:myo-inositol hexakisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038163">
        <property type="entry name" value="ITPK_uncN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="307"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="431" mass="47638" checksum="2E25E402F25C6262" modified="2016-04-13" version="1">MDMAIVSVGRIIHSENPMGGGVGGILLDSSVILDSTSNDDETATLRTGADYLLRKLRHSNIPTGISYAVGLSEAKVSLLEKLICVYSFEHFIYNPSSLDDTVNAVSLAWDNNGAIILHVVSKYNEGLVPKSFSSGWMNVFVNVDGDDASRNPTGIFIEKLEELPLTVCELNRKSSEGNLVVGYIMKPSREEDFAKRGAFPLNPTQNGLIFLPLTFDLPILTQLKKVEIVIHKATDEISSIERSNSSDCSSKIIYTRGMLELQRCIGELSDCCVIDPFDNIFPIVDRLKIQEILLGLEDLKTESQCKIRGPYYLKVDSFDDLELEQRLCGAKLSLPSIVKPQVACGAIVFKAADFTGLSVPLPAVVQEYVDHSSTLFKFYVLGEKIQEGTRDHVIVDVNYLPSFKEVPDEIAIPAFWDAIKMKYLSKKGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKB3</accession>
    <name>A0A103XKB3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_005623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="LEKV01004822">
        <property type="protein sequence ID" value="KVH92345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKB3"/>
    <dbReference type="Gramene" id="KVH92345">
        <property type="protein sequence ID" value="KVH92345"/>
        <property type="gene ID" value="Ccrd_005623"/>
    </dbReference>
    <dbReference type="OMA" id="AGHNYMT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22842">
        <property type="entry name" value="Gal_Rha_Lectin_BGal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000037">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000142">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000002">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000006">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118878" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="10">
        <location>
            <begin position="639"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="727" mass="80730" checksum="5E9EC771D6C3E368" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLI3</accession>
    <name>A0A103XLI3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA splicing factor, thioredoxin-like U5 snRNP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLI3"/>
    <dbReference type="STRING" id="59895.A0A103XLI3"/>
    <dbReference type="Gramene" id="KVH92943">
        <property type="protein sequence ID" value="KVH92943"/>
        <property type="gene ID" value="Ccrd_005015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="20273" checksum="AA8072EADBD48DDC" modified="2016-04-13" version="1">MEVGCGHKRSHDCFLLFQEGAERFVERKREERCRTCYRTCTQAGPSIKPSSPRRNVSLSSASAMIGMKLVCSKGESERGTEENGGRDKAVALIYLVDITEVPDFNTMYELYDPSTIMFFFRNKHIMIDLGTGNNNKINWAMKDKQEFIDIVETVYRGARKGRGLVIAPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLJ6</accession>
    <name>A0A103XLJ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LURP1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004798">
        <property type="protein sequence ID" value="KVH93035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLJ6"/>
    <dbReference type="STRING" id="59895.A0A103XLJ6"/>
    <dbReference type="Gramene" id="KVH93035">
        <property type="protein sequence ID" value="KVH93035"/>
        <property type="gene ID" value="Ccrd_004921"/>
    </dbReference>
    <dbReference type="OMA" id="FKRWEAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF60">
        <property type="entry name" value="PROTEIN LURP-ONE-RELATED 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="38135" checksum="B905125F67977380" modified="2016-04-13" version="1">MKGGGVIVEERFVYEKETHLTVMKTSLFFAGDGFTVYDTNAQIVFRVDSYGPDAHDAGELVLMDPSGRCVLTVRRKGSVNGDDKLIDQQRPSLHQRWEGFLGERKEGEKPIFSAKRSSMIGRSNVTVEVFGGRTEEYVIEGSFGHRNCTIYDSEKETMAEMRRKVDSSTNMKLGKDVFWLTLKAGFDAAFAMGLVLVLDQTNDDNGGDGDRPSLHQRWEGFLGERIEGENSKPIFSVRRSSIIGRSNMTVELFGDRTEEYLIEGCFGSRNCTIYDSGKERMAEIRRKVDATTNVMLGKDVFSLILKAGFDGAFAMGLVLVLDQINGDDEEDPATEEDCNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM52</accession>
    <name>A0A103XM52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004797">
        <property type="protein sequence ID" value="KVH93044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM52"/>
    <dbReference type="STRING" id="59895.A0A103XM52"/>
    <dbReference type="Gramene" id="KVH93044">
        <property type="protein sequence ID" value="KVH93044"/>
        <property type="gene ID" value="Ccrd_004906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF169">
        <property type="entry name" value="DYNAMIN-LIKE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23879" checksum="7F873355069DC2DC" modified="2016-04-13" version="1">MELMIPDCIGEKLPIPEIVALGGQSDGKSSLLEALRFRFNVREVEIGTRRPLILQMVHDPTALDPRCRVQAMKGEPESTPEEILSMVKSLASPLHRILVSLQQSSGEWCSSLWLDAILDIDPTFGRTLIVVSKFDNRLKVDANVLCHLRENINGGYEEESEVTAQLSTMDSKIQEEKSESGMGNWPGVIADIQPANATLRLYGGAAFERVMHEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XND1</accession>
    <name>A0A103XND1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004583">
        <property type="protein sequence ID" value="KVH93951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XND1"/>
    <dbReference type="STRING" id="59895.A0A103XND1"/>
    <dbReference type="Gramene" id="KVH93951">
        <property type="protein sequence ID" value="KVH93951"/>
        <property type="gene ID" value="Ccrd_003999"/>
    </dbReference>
    <dbReference type="OMA" id="CRPEIIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044820">
        <property type="entry name" value="AGD14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085:SF3">
        <property type="entry name" value="ARF GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085">
        <property type="entry name" value="ARFGAP/RECO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="657" mass="70520" checksum="60EA34365F06E7D5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNK4</accession>
    <name>A0A103XNK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004580">
        <property type="protein sequence ID" value="KVH93975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNK4"/>
    <dbReference type="Gramene" id="KVH93975">
        <property type="protein sequence ID" value="KVH93975"/>
        <property type="gene ID" value="Ccrd_003980"/>
    </dbReference>
    <dbReference type="OMA" id="VITWIHP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36810">
        <property type="entry name" value="BNACNNG47150D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36810:SF1">
        <property type="entry name" value="OS05G0232200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="759" mass="83986" checksum="D748A01797B655A9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS26</accession>
    <name>A0A103XS26_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004375">
        <property type="protein sequence ID" value="KVH95855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS26"/>
    <dbReference type="STRING" id="59895.A0A103XS26"/>
    <dbReference type="Gramene" id="KVH95855">
        <property type="protein sequence ID" value="KVH95855"/>
        <property type="gene ID" value="Ccrd_002072"/>
    </dbReference>
    <dbReference type="OMA" id="KHVDPSP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039923">
        <property type="entry name" value="Protodermal_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33210">
        <property type="entry name" value="PROTODERMAL FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33210:SF18">
        <property type="entry name" value="PROTODERMAL FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="251" mass="25953" checksum="92E29AE833D61926" modified="2016-04-13" version="1">MERSRRSQTSCLLVCGLVAALLSQNFVFLAASSSFQDEKNFYFPPIDPNVGSPPVALSPPIVPSPPIGYGPYGTPPPTRGSGGSTPPVHHTPSHGGGGHHHHGGSPPVNCGNPTPHHSPPKHVDPSPVPPTPSTGHHNPSPAPPTGGYHYYPPPSNGGSVPSSPPIVLPPTTPGIPFPSSPPFDPHSPPVIGGTCEEGTASLLNSMVNKNFPFTTSHVRDSFVAAVGSNKAATAQARVFKLANEGHMKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSK9</accession>
    <name>A0A103XSK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSK9"/>
    <dbReference type="STRING" id="59895.A0A103XSK9"/>
    <dbReference type="Gramene" id="KVH96108">
        <property type="protein sequence ID" value="KVH96108"/>
        <property type="gene ID" value="Ccrd_001804"/>
    </dbReference>
    <dbReference type="OMA" id="AKCECKS"/>
    <dbReference type="OrthoDB" id="1565598at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17103" checksum="663AA8977E14A9E8" modified="2016-04-13" version="1">MAVVTSELEIPSSVSASKLFKAFLDFRNLAPKVEPESFKAIEFIKGDGGIGTVQQTTFVDGSKSKLTIDAIDHNNFSLGTTIFEGGEWMDNLESATYHAKFVPSAANDGSTYKVSSVYKCKDPAKFTEENAKFADEYTKKTFKAIEAYIIANPNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSR5</accession>
    <name>A0A103XSR5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SPIRAL1-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPIRAL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004348">
        <property type="protein sequence ID" value="KVH96203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSR5"/>
    <dbReference type="STRING" id="59895.A0A103XSR5"/>
    <dbReference type="Gramene" id="KVH96203">
        <property type="protein sequence ID" value="KVH96203"/>
        <property type="gene ID" value="Ccrd_001716"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62622at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010005">
        <property type="term" value="C:cortical microtubule, transverse to long axis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039613">
        <property type="entry name" value="SPR1/2/3/4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33403:SF45">
        <property type="entry name" value="SPIRAL1-LIKE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33403">
        <property type="entry name" value="SPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="11431" checksum="E4DBB7271385844A" modified="2016-04-13" version="1">MNRGGSSGGGQSSLGYLFGSGEAPKPAPKATQAAPCETPAANNVTAAKPDPVSPPVDIAKQVPAGINSNPSNNYFRADGQNTGNFITERPSTKVHNAPGGGSSLGYLFGSGGGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTA4</accession>
    <name>A0A103XTA4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004280">
        <property type="protein sequence ID" value="KVH96500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTA4"/>
    <dbReference type="Gramene" id="KVH96500">
        <property type="protein sequence ID" value="KVH96500"/>
        <property type="gene ID" value="Ccrd_001413"/>
    </dbReference>
    <dbReference type="OMA" id="MEINAGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF34">
        <property type="entry name" value="OS08G0555500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="24270" checksum="03FCF884858399BD" modified="2016-04-13" version="1" fragment="single">YKKKKESKISNTAENLVDVDDQSNEVAILNVGQAKQRATDCSTRRETICKRPPKSREDSKDDDDFEVQDQNKRKKVKSVKEDTKGIEDNGKCTIKTHLPLCTRTSPKPLYTMIQNLPPSQIECVKEMGFEGLLNMKTDGIPAKLGYYVVDSFDSQNMLIKLENTVIPITVKKIHEMIGAPIGGAPLDSLVNDNCGVNVVEQWKSRYLKPSLRVTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWN7</accession>
    <name>A0A103XWN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003805">
        <property type="protein sequence ID" value="KVH98256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWN7"/>
    <dbReference type="Gramene" id="KVH98256">
        <property type="protein sequence ID" value="KVH98256"/>
        <property type="gene ID" value="Ccrd_023532"/>
    </dbReference>
    <dbReference type="OMA" id="NLQHGQE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000627">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000637">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF375">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="665" mass="74723" checksum="806D8F202722AC95" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWU8</accession>
    <name>A0A103XWU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWU8"/>
    <dbReference type="Gramene" id="KVH98338">
        <property type="protein sequence ID" value="KVH98338"/>
        <property type="gene ID" value="Ccrd_023412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="309" mass="33899" checksum="45EE6A2C944BA4BA" modified="2016-04-13" version="1">MSFLELRMANNELCVAMNREVEAEGAGASQVVRPLFLSAIKKVKGVLRKMVEGKTVGPDQIPIEKAKTQAKGVAPTRIASAGAAKERESGTDKEKATSSWGSIKKTDHKDGNIGDQVLQHHNKLKRKGSINMTGAAGKNYIVKEGSKMFAVKCKGLHSALNLLLALLENSYQQEELDKWFRINKVGPNFWPLSPSAQQLTITQTEDFQIDVASKSGFNPSQYGLKNFSFSPLSTMLQIPPIVNATLNATPSHPNDQLKYQLKLYFVGFLISTHIKHGYANVTGRVSPPNNPARLERNGSATPMKKLMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWY1</accession>
    <name>A0A103XWY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_023415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWY1"/>
    <dbReference type="STRING" id="59895.A0A103XWY1"/>
    <dbReference type="Gramene" id="KVH98341">
        <property type="protein sequence ID" value="KVH98341"/>
        <property type="gene ID" value="Ccrd_023415"/>
    </dbReference>
    <dbReference type="OMA" id="LAYEMKP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000012">
        <property type="entry name" value="Peptidase/ serine-type peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="SIGNAL PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390:SF2">
        <property type="entry name" value="THYLAKOIDAL PROCESSING PEPTIDASE 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="188"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH98341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="347" mass="37229" checksum="AE09CDA1E34D47A6" modified="2016-04-13" version="1">MAIRFTVSYSGYVAQNLASSAAGKTNTCRIFHEVFSRPRMFQKPDRDVSTGYRPAATAATRNSVSAYATLASEFLGVESSNKPSPLVVGLISLVKSAATGGCSGGGSGVFGISPLKASSIIPFLQGSKWLPCNEINSSEVDKGGTKTKNNNQSSSDCLKSCDVVGGKAMIVERNNWLSKLLNVCSDDAKAAFTALSVSILFRSQLAEPRSIPSQSMSPTLDVGDRILAEKVSYIFRNPEVSDIVIFKAPPILQEIGYSSGDVFIKRIVAKAGDCVEVREGELLVNGVVQDEEFILEPLAYEMEPMLVPEGGPLPVENIVGRSVLRYWPPTKISDTIYEAKRGVAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXE9</accession>
    <name>A0A103XXE9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003776">
        <property type="protein sequence ID" value="KVH98642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XXE9"/>
    <dbReference type="Gramene" id="KVH98642">
        <property type="protein sequence ID" value="KVH98642"/>
        <property type="gene ID" value="Ccrd_023134"/>
    </dbReference>
    <dbReference type="OMA" id="EDDVWEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053296">
        <property type="entry name" value="TSET_member_tstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48151">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48151:SF3">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1397"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1535" mass="168937" checksum="A222BD416F546535" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXW9</accession>
    <name>A0A103XXW9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003640">
        <property type="protein sequence ID" value="KVH98975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXW9"/>
    <dbReference type="Gramene" id="KVH98975">
        <property type="protein sequence ID" value="KVH98975"/>
        <property type="gene ID" value="Ccrd_022761"/>
    </dbReference>
    <dbReference type="OMA" id="IGTGPQQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000003">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF175">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="32229" checksum="3F63F955E5D08C91" modified="2016-04-13" version="1">MCCVGNVVSFMVFLSPLPTFYKVYKKKSTEGFQSVPYVVGLFSAMLWIYYALLKSNAMLLITINSVGCFIQTFYICFFLIYAPKKARIESVKLIVLMIVVGFGLIVALTQFLAHGATRVAIVGWICLIFALCVFVAPLGVVRQVIKTKSVEYMPILLSAALTLNAITWFFYGLLLHDFNIAIPNVLGFTFGVVQMILYFVYKNKKPVSDEKVSDEKVTELEGKNLETEERKISEKRDQEIIDVVRLSALMCSIPVVTKLNENVNDIVHDHLVVEPPQAPVAHAIEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ97</accession>
    <name>A0A103XZ97_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent/calcium-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003427">
        <property type="protein sequence ID" value="KVH99635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ97"/>
    <dbReference type="STRING" id="59895.A0A103XZ97"/>
    <dbReference type="Gramene" id="KVH99635">
        <property type="protein sequence ID" value="KVH99635"/>
        <property type="gene ID" value="Ccrd_022119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF162">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13791" checksum="65A6A8CC7A7F9D4B" modified="2016-04-13" version="1">MILWRNLVPASEIDKESMGNTRWGGVELFAKVAKGQLKEDLTRKYFQQLVNVIHYCHIRSVSHHDLKPKNLLLDENEDLKLRNKGMLHTQCGSGTSSYVMPEVLQKKAMIMPWWISGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y056</accession>
    <name>A0A103Y056_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVI00021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y056"/>
    <dbReference type="STRING" id="59895.A0A103Y056"/>
    <dbReference type="Gramene" id="KVI00021">
        <property type="protein sequence ID" value="KVI00021"/>
        <property type="gene ID" value="Ccrd_021804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00232">
        <property type="entry name" value="Shadow ORF (opposite metK)"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044193">
        <property type="entry name" value="TRL33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47571">
        <property type="entry name" value="THIOREDOXIN-LIKE 3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47571:SF1">
        <property type="entry name" value="THIOREDOXIN-LIKE 3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24917" checksum="9189A7F258ACCBC1" modified="2016-04-13" version="1">MGKTEAMEATKTQEKPINRHGNLTTASSDENLKDIFHEIRTSRSPAVINFDIDECPETTQHIRYTPTFHFYRDGERVDAMFGAGFRFENLGGLPGEIRIFATKMAISSSLLVPVVATPLQVEINRHHPWPKVEILLDQDKDILIWDCSSFIRVHKHGKGLSHTNSVRNLNEAPPCKSRSYYTLSSLPNNISTTPVHFGRILSGECTSTVSSPSTIGVDDNLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0G3</accession>
    <name>A0A103Y0G3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0G3"/>
    <dbReference type="Gramene" id="KVI00250">
        <property type="protein sequence ID" value="KVI00250"/>
        <property type="gene ID" value="Ccrd_021493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="228" mass="25493" checksum="FD701C2B582B9789" modified="2016-04-13" version="1">MGTTTALAPGLSRKLKKVLETRIDNPDLMAAFHSEINSFEGYYFLPEFCKDVAVKYIKECHYMRELNISVSLVENYFNGVSPDDGGRDVVLMDTDDFLPDDILRTNPLLYGASDSWNMPVSFISVILLPIVGNAAEHASAIMFAMKDKLLSDITLGVAIGSSTHISMFVPKKMGLESNPIRTRRDHMKNTQLTDSIYFERLFVDSLDADVGIDAFTVTVKVEIELLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2G1</accession>
    <name>A0A103Y2G1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003121">
        <property type="protein sequence ID" value="KVI01299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2G1"/>
    <dbReference type="STRING" id="59895.A0A103Y2G1"/>
    <dbReference type="Gramene" id="KVI01299">
        <property type="protein sequence ID" value="KVI01299"/>
        <property type="gene ID" value="Ccrd_020432"/>
    </dbReference>
    <dbReference type="OMA" id="EAPYYKI"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="377" mass="43841" checksum="83DA41D45AE9C7B7" modified="2016-04-13" version="1">MGAVNIWNAMEVSGEARNNYDFEIVHSSLIVDHSLPLSEMKPRLVELCKDLFKHWSNLNESHFFAEKVSGGITNLLMKVSVKEENGNMVHVTVRLYGPNTEYVIDRERELQALHHLSAAGFGAKLLGVFGNGMVQSFIDARTLNPSDMRKPNLAAEIAKQLNRFHQVDIPGSREPQLWNDILKFFESASNLTFDDDEKQEKFVKISFEEVRAEITKLKELTGRLDAPVVFAHNDLLSGNLMLNDVEEKLYFIDFEYGSYNYRGFDIGNHFNEYAGYNCDYTLYPNKNEQYHFFRHYLNPEKPNEVSDNDLEALYIETNCYMLASHLYWALWALIQAKMSPIDFDYLGYFFLRYDEYKKQKNRCFSMAKSYLSRSNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2G9</accession>
    <name>A0A103Y2G9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003121">
        <property type="protein sequence ID" value="KVI01297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2G9"/>
    <dbReference type="STRING" id="59895.A0A103Y2G9"/>
    <dbReference type="Gramene" id="KVI01297">
        <property type="protein sequence ID" value="KVI01297"/>
        <property type="gene ID" value="Ccrd_020441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37713">
        <property type="entry name" value="OS05G0176600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37713:SF1">
        <property type="entry name" value="OS05G0176600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="120" mass="13463" checksum="794F34F33AFDFF1D" modified="2016-04-13" version="1" fragment="single">KHHFLEERAKKLENFGSRNSQRRSESEVPPSAIPNFDFKIPAMSSSSSHPAEGDDVYIRQSKGAPFKFLVPLIYAPVLPLIRIALKHKPVLRDRLFIGVLVGAFAHGSYLVSDLYDSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3L3</accession>
    <name>A0A103Y3L3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002675">
        <property type="protein sequence ID" value="KVI01866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3L3"/>
    <dbReference type="STRING" id="59895.A0A103Y3L3"/>
    <dbReference type="Gramene" id="KVI01866">
        <property type="protein sequence ID" value="KVI01866"/>
        <property type="gene ID" value="Ccrd_019857"/>
    </dbReference>
    <dbReference type="OMA" id="FTCERRG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053283">
        <property type="entry name" value="TUNICAMYCIN_INDUCED_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454:SF2">
        <property type="entry name" value="PROTEIN TUNICAMYCIN INDUCED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454">
        <property type="entry name" value="TUNICAMYCIN INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119356" evidence="1">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="44235" checksum="BE71F6B42E172CB7" modified="2016-04-13" version="1">MAVRVLNFAGYLLFYSLIIRFSSSAASISKPDDLQEVIVKGLGFQSNDLKISGFDLRMVDPLFMSYIQKLMIKWTGSREEEKTKKKGLQGSPVLSPFQLAGPMELWIQDAKDMRLPLPGAKSVGLLRAVELDLPLNKTQNRFASGILTPADRLRHAYRPTSLTSPKLSPSSNKLKLKRLAPGLVELSSTLKPNSTNSISAIDLREIMAVRVPKWVKPTLDWFRGTTLRPRFWVLKPRSRVFFRLLRADVSAQTFMKIGFTVEKLSGNGSEWAGYPKWRTKPEIMRMHFEVLAKVDGEKIVPERLIQVDPVMVKDTMATNLITGHITSSSTISIIYPLKEQGGLTYKVDDSDYKVQILKHGSSFSFTCERRGRIVTPACPPTTGTLTSLGSSPKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4C9</accession>
    <name>A0A103Y4C9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin-like family. Class-I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002659">
        <property type="protein sequence ID" value="KVI02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4C9"/>
    <dbReference type="STRING" id="59895.A0A103Y4C9"/>
    <dbReference type="Gramene" id="KVI02303">
        <property type="protein sequence ID" value="KVI02303"/>
        <property type="gene ID" value="Ccrd_019447"/>
    </dbReference>
    <dbReference type="OMA" id="WLNCRIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027643">
        <property type="entry name" value="Formin-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213:SF360">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213">
        <property type="entry name" value="FORMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119388" description="Formin-like protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="341"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="852" mass="94339" checksum="24AD2EDA6822EA55" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4Q1</accession>
    <name>A0A103Y4Q1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4Q1"/>
    <dbReference type="STRING" id="59895.A0A103Y4Q1"/>
    <dbReference type="Gramene" id="KVI02486">
        <property type="protein sequence ID" value="KVI02486"/>
        <property type="gene ID" value="Ccrd_019260"/>
    </dbReference>
    <dbReference type="OMA" id="YIRCVPG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43936" checksum="EAA2354C8EA5FC68" modified="2016-04-13" version="1">MGGMTSSMAAKFAFFPPNPPSYKLVKDDLTGLLLLSPFPHRENVEVLKLTTRRGSEIVAIYVRHPMATSTVLYSHGNAADLGQMYELFIELSIRLRVNLMGYDYSGYGQSSGKVGEFGKFIAKIGRKCHHLQVHLFHVVQPSENNTYADIEAVYKCLEESYGTKQEDVVLYGQSVGSGPTLDLAVRLPRLRAVVLHSPILSGLRVMYPVKRTYWFDIYKGTADEVVDFCHGKQLWELSKEKYEPLWIKGGNHCDLELYPEYIRHLKKFISTVEKSPSHRHSSSRRSTDHHFEPPRRSTDVFEASRKSTDRREKPRKSTEKVKTQSVEKMRMSFDQIERSRRSVDVIEKSRKSVDLQQLERGRKSVDRMDRVRELGSSRFDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y578</accession>
    <name>A0A103Y578_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_018965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002640">
        <property type="protein sequence ID" value="KVI02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y578"/>
    <dbReference type="STRING" id="59895.A0A103Y578"/>
    <dbReference type="Gramene" id="KVI02750">
        <property type="protein sequence ID" value="KVI02750"/>
        <property type="gene ID" value="Ccrd_018965"/>
    </dbReference>
    <dbReference type="OMA" id="FYVHENI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000241">
        <property type="entry name" value="homeobox-leucine zipper protein ATHB-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF527">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="214" mass="24741" checksum="0BB606C21A9B969C" modified="2016-04-13" version="1">MTTNMKTQADDQMVLLSQYYPGIYDQLMPEQGEVVKPRRRRKKSKTDGGSSGMKKRKLSDEQVNLLEQNFGNEHKLESERKDRLASELGLDPRQVAVWFQNRRARWKSKKLEEEYSKLKSEHDSTVLEKCRLETEVNHRSVQVLKLKEQLSEAEKEINRLVERSDGISSTSPSSSFSMEAMEPPFLGGFGMEGLENVFCLPENNYIHGLDWLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5F5</accession>
    <name>A0A103Y5F5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5F5"/>
    <dbReference type="STRING" id="59895.A0A103Y5F5"/>
    <dbReference type="Gramene" id="KVI02841">
        <property type="protein sequence ID" value="KVI02841"/>
        <property type="gene ID" value="Ccrd_018880"/>
    </dbReference>
    <dbReference type="OMA" id="WSMLSGS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010608">
        <property type="entry name" value="DUF1195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34358">
        <property type="entry name" value="OS03G0411600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34358:SF11">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06708">
        <property type="entry name" value="DUF1195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="180" mass="20433" checksum="3448AE123B334288" modified="2016-04-13" version="1">MKDDDPLPMSTPPLMITNKKESLDSSIFSRGRYKFWALAAIILLAFWSMLTGTVTLRFSAGNLNRLGDYDIAGGSPIHEDLDVLVRTEMEEREKVVKHMWDVYTNGRRIKLPRFWQEAFVAAYEDLSSDAPEVREAAISEIAKMSINSIDLDLPPQLTNIRELSSKQSQQNKARSKLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5I9</accession>
    <name>A0A103Y5I9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein preY, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PREY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002613">
        <property type="protein sequence ID" value="KVI02917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5I9"/>
    <dbReference type="STRING" id="59895.A0A103Y5I9"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000023">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505:SF4">
        <property type="entry name" value="PROTEIN PREY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505">
        <property type="entry name" value="ZGC:162634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="13509" checksum="0ECA5221737ECDCF" modified="2016-04-13" version="1" fragment="single">LVKHDPTSFYIGYKISPGYHRNKPNRQEEEKKTKRMVRGTRIVEISKSLSEILVCPLSKQPLRVCEKSNSLISHAIGVSFPIVDGIPCLVPQDGKIIEAEDSNSNGDTVDTKRYHQDGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5J3</accession>
    <name>A0A103Y5J3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002616">
        <property type="protein sequence ID" value="KVI02914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5J3"/>
    <dbReference type="Gramene" id="KVI02914">
        <property type="protein sequence ID" value="KVI02914"/>
        <property type="gene ID" value="Ccrd_018795"/>
    </dbReference>
    <dbReference type="OMA" id="GDIRNTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="132" mass="13913" checksum="2EF78EEE37AC52FF" modified="2016-04-13" version="1">MECHDAGATPPATLAEFTLGSGSTQDFYDVSLVDGYNLQMIVEVNGGSGNCVTTGCVDDLNRWCPTELRVDGGGGCRSACDAFGSPEYCCKGAFGTPETCRPTAYAQWSKHSSVNFMPSTILQAKPKAIVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6T4</accession>
    <name>A0A103Y6T4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the GTPase NUG2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002342">
        <property type="protein sequence ID" value="KVI03574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6T4"/>
    <dbReference type="STRING" id="59895.A0A103Y6T4"/>
    <dbReference type="Gramene" id="KVI03574">
        <property type="protein sequence ID" value="KVI03574"/>
        <property type="gene ID" value="Ccrd_018137"/>
    </dbReference>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000005">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="208" mass="23637" checksum="642BEA07E1283105" modified="2016-04-13" version="1">MSKLGSEAVREAITQITTEAKEKNRKFTETIELQIGLKNYDPQKDKRFSGTVKLPHIPRPKLKVCMLGDAQHAQKIGLEYMDVEGLKKLNKNKKLVKKLAKKHQAFLASESVIKQIPRLLGPGKFPTLVTHQESLESKVNEIKATVKFQLKKVLCMGVAVGNCSMEEKQIFQNVQMSVNFLVSLLKKNWQNVRCLYLKTTMGKPVRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y709</accession>
    <name>A0A103Y709_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002334">
        <property type="protein sequence ID" value="KVI03687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y709"/>
    <dbReference type="STRING" id="59895.A0A103Y709"/>
    <dbReference type="Gramene" id="KVI03687">
        <property type="protein sequence ID" value="KVI03687"/>
        <property type="gene ID" value="Ccrd_018017"/>
    </dbReference>
    <dbReference type="OMA" id="MENCNTT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47674">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47674:SF3">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="108" mass="11856" checksum="CF9A94DD0A8B2865" modified="2016-04-13" version="1">MDVASESHRIARLGLDRNLDDEEEELRLSAQARARLADPSNSEANSKYVVDIFGQTHPPVASEIFDCMNCGRSIVAGRFAPHLEKCMGKGRKARVKATRSSTAAAQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y726</accession>
    <name>A0A103Y726_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cohesin loading factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y726"/>
    <dbReference type="STRING" id="59895.A0A103Y726"/>
    <dbReference type="Gramene" id="KVI03704">
        <property type="protein sequence ID" value="KVI03704"/>
        <property type="gene ID" value="Ccrd_017956"/>
    </dbReference>
    <dbReference type="OMA" id="QDAWYLS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000614">
        <property type="entry name" value="Sister chromatid cohesion protein SCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI03704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="722" mass="81078" checksum="D160D79709BDD28A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7A9</accession>
    <name>A0A103Y7A9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_017850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7A9"/>
    <dbReference type="Gramene" id="KVI03845">
        <property type="protein sequence ID" value="KVI03845"/>
        <property type="gene ID" value="Ccrd_017850"/>
    </dbReference>
    <dbReference type="OMA" id="GPFLKHD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000002">
        <property type="entry name" value="ABC transporter C family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF189">
        <property type="entry name" value="ABC TRANSPORTER C FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="921"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="975"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="328"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="608"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="936"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI03845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1370" mass="153206" checksum="E0A9B47D1F178F38" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8M6</accession>
    <name>A0A103Y8M6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002012">
        <property type="protein sequence ID" value="KVI04536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8M6"/>
    <dbReference type="STRING" id="59895.A0A103Y8M6"/>
    <dbReference type="Gramene" id="KVI04536">
        <property type="protein sequence ID" value="KVI04536"/>
        <property type="gene ID" value="Ccrd_017148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15921" checksum="8D2677CBD6D31E7A" modified="2016-04-13" version="1">MNCRRALAEISHRCFALKRNRPSLLCSALLANLSLVNGQWINALDTVVKKILCQSDAAEFLVAFAGIQETVHQVEQQDYTAHKSKLEADLARRAEHYFSDNMRVIKDTLQSDEASSSVQSNKRGSTRADYKKVRKEMAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9H4</accession>
    <name>A0A103Y9H4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_016679</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01001892">
        <property type="protein sequence ID" value="KVI04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9H4"/>
    <dbReference type="Gramene" id="KVI04991">
        <property type="protein sequence ID" value="KVI04991"/>
        <property type="gene ID" value="Ccrd_016679"/>
    </dbReference>
    <dbReference type="OMA" id="YAICNIN"/>
    <dbReference type="OrthoDB" id="785331at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000004">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF232">
        <property type="entry name" value="S-LOCUS GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119511" description="Receptor-like serine/threonine-protein kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="15">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="16">
        <location>
            <begin position="340"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="506"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="817" mass="92282" checksum="3649DF1F58A399F1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA67</accession>
    <name>A0A103YA67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001873">
        <property type="protein sequence ID" value="KVI05369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA67"/>
    <dbReference type="Gramene" id="KVI05369">
        <property type="protein sequence ID" value="KVI05369"/>
        <property type="gene ID" value="Ccrd_016296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="13547" checksum="763254AE95D9D31D" modified="2016-04-13" version="1">MMMPPKHHLSPTSPENTSVTTAAVSSLTHRLSEVTRTPTRKNVSTSSELKFKPLGETQSSPSPPSLPHLTSSHTPTGSYFPPPLRLHHGSTFHVPIRLAMDASLHRRRVDRYGVRYHHLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAM2</accession>
    <name>A0A103YAM2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin repeat-like-containing domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001868">
        <property type="protein sequence ID" value="KVI05571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAM2"/>
    <dbReference type="STRING" id="59895.A0A103YAM2"/>
    <dbReference type="Gramene" id="KVI05571">
        <property type="protein sequence ID" value="KVI05571"/>
        <property type="gene ID" value="Ccrd_016077"/>
    </dbReference>
    <dbReference type="OMA" id="EMCEDIG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1220:FF:000001">
        <property type="entry name" value="Exocyst complex component EXO84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF15">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT EXO84A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI05571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="800" mass="88840" checksum="EE573B5041A34331" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAP4</accession>
    <name>A0A103YAP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAP4"/>
    <dbReference type="STRING" id="59895.A0A103YAP4"/>
    <dbReference type="Gramene" id="KVI05605">
        <property type="protein sequence ID" value="KVI05605"/>
        <property type="gene ID" value="Ccrd_016047"/>
    </dbReference>
    <dbReference type="OMA" id="MVIMEGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35453" checksum="F891B07117283224" modified="2016-04-13" version="1">METNKMIMVLTELVPCMLMVLMEVSTIGLTILASTILRDDLITQFLLLGFVGVTMAQNLAYVGLSYSSPIVACGMGNIIPSISFILAAICRRTEVDLRSSSTRTKLMGTLISIIGAVSLVLYRGPVIKDSSTHLRLAPRLFVFLATKEHWVVGCVLFACASLAFSIWNIIQVGTIEKCPEVMTVASSYTLFGTVQSTLVAIIVENDPLAWRLQFDMGLLVIVLTAIFGSLIRTHVHMWCIRRKGQFYVTMFKPLGVPIASTFGCIFFAETFHYGSMMSAAVTGIGYYTMMWGQMREDESRRGKVDLLEEKAPLLQEEDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBA8</accession>
    <name>A0A103YBA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015694</name>
        <name evidence="9" type="ORF">Ccrd_015695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI06010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBA8"/>
    <dbReference type="Gramene" id="KVI05944">
        <property type="protein sequence ID" value="KVI05944"/>
        <property type="gene ID" value="Ccrd_015695"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI06010">
        <property type="protein sequence ID" value="KVI06010"/>
        <property type="gene ID" value="Ccrd_015694"/>
    </dbReference>
    <dbReference type="OMA" id="HYNYYYW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17416">
        <property type="entry name" value="MFS_NPF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000062">
        <property type="entry name" value="Protein NRT1/ PTR FAMILY 1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="63643" checksum="28B3104A45EAB5F7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBX7</accession>
    <name>A0A103YBX7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="LEKV01001843">
        <property type="protein sequence ID" value="KVI06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBX7"/>
    <dbReference type="STRING" id="59895.A0A103YBX7"/>
    <dbReference type="Gramene" id="KVI06262">
        <property type="protein sequence ID" value="KVI06262"/>
        <property type="gene ID" value="Ccrd_015430"/>
    </dbReference>
    <dbReference type="OMA" id="NIIDWFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF33">
        <property type="entry name" value="ALPHA-GALACTOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119571" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="359"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="443" mass="49990" checksum="420EB7A26B645A3A" modified="2016-04-13" version="1">MMHLKVVLCYFSLLVVSIRFSSSEAARTTFSSTNQRRSLLENGLGRTPQMGWNSWNHFACNIEEKLIRETADAMVSTGLAAAGYQYVNIDDCWAELDRDSRGDFVPKASTFPSGIKALADYVHNKGLKLGIYSDAGYLRHNKPPLLKFNPSRKKGIQVIYNSKKLKILYFPKFVGDGFILFCEKRYPIMTKALQNSGRPIFYSLCEWGQDDPATWANEVGNSWRTTGDISDNWDRYGYDLTRTQPNILRFFVVTRNDYIFILISTSMTSRADENDKWASYAKPGGWNDPDMLEVGNGGMTTEEYRSHFSIWALAKAPLLVGCDVRSMSKETHEILSNKEVIAVNQDSLGVQGKKVKKNGDLEVWAGPLQHNKVVVILWNRSGSTSQITAYWSDIGLDSTTIVNARDLWAVRLQKIHSTQKSIKGQISATIQSHACKMYVLTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCS3</accession>
    <name>A0A103YCS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock protein 70 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001728">
        <property type="protein sequence ID" value="KVI06716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCS3"/>
    <dbReference type="STRING" id="59895.A0A103YCS3"/>
    <dbReference type="Gramene" id="KVI06716">
        <property type="protein sequence ID" value="KVI06716"/>
        <property type="gene ID" value="Ccrd_014928"/>
    </dbReference>
    <dbReference type="OMA" id="NIMCIIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12722" checksum="28A01AFE422A6D1D" modified="2016-04-13" version="1" fragment="single">METLSLIALLSESSFLLKKFQHRTATKDVGRIAGLEVLRIINEPTAASIAYGFERKNNETILVFDLGGGTFDVSVLEIGDGVFEVLSTSRDTHLGGDDFDKRVVDWLAASFKKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDC9</accession>
    <name>A0A103YDC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bulb-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001531">
        <property type="protein sequence ID" value="KVI07013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDC9"/>
    <dbReference type="STRING" id="59895.A0A103YDC9"/>
    <dbReference type="Gramene" id="KVI07013">
        <property type="protein sequence ID" value="KVI07013"/>
        <property type="gene ID" value="Ccrd_014618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF247">
        <property type="entry name" value="OS01G0958200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="19101" checksum="B8C90B607214A737" modified="2016-04-13" version="1">MISTSSTSVSVVLLDNGNLVLRNGSRSSPPIWQSFDHPAHTLLPHSKIGYDKRTHRKQVITSWRSREDPAVGLFSLEIDPNVPQWVLRWNKSVQYWTSGYANRQIFSSMPEIRLNDLYNFSYINNENESYFDYSVYDPSIISRCLRAHPAADMVWKCGAVACDLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE53</accession>
    <name>A0A103YE53_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ethylene receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">Ccrd_014245</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling.</text>
    </comment>
    <comment type="function">
        <text evidence="22">May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="23">Binds 1 copper ion per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Heteromer with ETR1. Binds to MRF3/ECIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the ethylene receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001507">
        <property type="protein sequence ID" value="KVI07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE53"/>
    <dbReference type="STRING" id="59895.A0A103YE53"/>
    <dbReference type="Gramene" id="KVI07439">
        <property type="protein sequence ID" value="KVI07439"/>
        <property type="gene ID" value="Ccrd_014245"/>
    </dbReference>
    <dbReference type="OMA" id="FNCCDED"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051740">
        <property type="term" value="F:ethylene binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038199">
        <property type="term" value="F:ethylene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010105">
        <property type="term" value="P:negative regulation of ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16938">
        <property type="entry name" value="HATPase_ETR2_ERS2-EIN4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19933">
        <property type="entry name" value="REC_ETR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000240">
        <property type="entry name" value="Ethylene receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000087">
        <property type="entry name" value="Ethylene receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014525">
        <property type="entry name" value="ETR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058544">
        <property type="entry name" value="ETR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24423:SF629">
        <property type="entry name" value="PROTEIN EIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24423">
        <property type="entry name" value="TWO-COMPONENT SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25487">
        <property type="entry name" value="ETR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026389">
        <property type="entry name" value="Ethyln_sen_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15 22 23" id="KW-0186">Copper</keyword>
    <keyword evidence="18 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 22" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 22 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 26" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="29" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16 22" id="KW-0902">Two-component regulatory system</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119635" description="Ethylene receptor" evidence="29">
        <location>
            <begin position="22"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="30">
        <location>
            <begin position="373"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="31">
        <location>
            <begin position="637"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="26">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="24">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="24">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="25">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR026389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KVI07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="764" mass="85674" checksum="96E367A9356397CA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF09</accession>
    <name>A0A103YF09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001470">
        <property type="protein sequence ID" value="KVI07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF09"/>
    <dbReference type="STRING" id="59895.A0A103YF09"/>
    <dbReference type="Gramene" id="KVI07894">
        <property type="protein sequence ID" value="KVI07894"/>
        <property type="gene ID" value="Ccrd_013745"/>
    </dbReference>
    <dbReference type="OMA" id="APKILNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009735">
        <property type="term" value="P:response to cytokinin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009739">
        <property type="term" value="P:response to gibberellin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000017">
        <property type="entry name" value="Transcription termination factor MTEF18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF113">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTEF18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="561" mass="65427" checksum="65876D4F236314E1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFT1</accession>
    <name>A0A103YFT1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial fission ELM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001143">
        <property type="protein sequence ID" value="KVI08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFT1"/>
    <dbReference type="Gramene" id="KVI08307">
        <property type="protein sequence ID" value="KVI08307"/>
        <property type="gene ID" value="Ccrd_013320"/>
    </dbReference>
    <dbReference type="OMA" id="TASCIVT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009367">
        <property type="entry name" value="Elm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33986:SF17">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROTEIN ELM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33986">
        <property type="entry name" value="OS02G0535700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06258">
        <property type="entry name" value="Mito_fiss_Elm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="44514" checksum="E8F21132DD051F65" modified="2016-04-13" version="1">MHRTVRRAVIIGNGFAGAENQCYGLIRALGLFNRHSFYRVRRPKDGISKWLNWLPVSTHKRLDQLKRQLYDRQFIFSGHGQKAAARLGELMPHSAVNAGADQSDIQEADAQLIATNASENFEKDGPLLVVASGRDTISVASSIKRLAPHHVFNIQIQHPRSHLNRFDLVISPCHDYYPLTPEGKKHIPWFLRMWITPRQPPGRNVVLTLAALHQVDSAAVQSAASAWHDELASLLRPLLVINIGGPIRHCRYGADLARELTASLINVLPTCGSVRISFSRRTPKQVSEIVVREFHNHPKVYIWDGEDPNPHMGHLAWADAFVITADSPVYVIGAERCTWKFAYFQKCLQERGIVRPFTGKENISETWIYPPLRDTAEAAEHVIEALAGRGWKLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGL8</accession>
    <name>A0A103YGL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001091">
        <property type="protein sequence ID" value="KVI08744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGL8"/>
    <dbReference type="Gramene" id="KVI08744">
        <property type="protein sequence ID" value="KVI08744"/>
        <property type="gene ID" value="Ccrd_012867"/>
    </dbReference>
    <dbReference type="OMA" id="ILWHSDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027367">
        <property type="entry name" value="Gly-zipper_YMGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46151:SF7">
        <property type="entry name" value="NEP1-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46151">
        <property type="entry name" value="NEP1-INTERACTING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13441">
        <property type="entry name" value="Gly-zipper_YMGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="YMGG-like Gly-zipper" evidence="7">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI08744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="29829" checksum="E46C38646A74C250" modified="2016-04-13" version="1" fragment="single">QRPSNFIQHTQRDPLCTRHPSKPSLHPFDHTINQNPDSEMEFFTHPSRSSQISSVTFTNLVVKVKDFFSSAVSAILGNVFSAIFTFFFALVGTLLGALTGALIGQETESGFVRGAAVGAISGAVFSIEVFESSLLLWQSDESGFGCLLYLIDVIVSLISGRLVRERIGPAMLSAVQSQMGAVETSFDEVHNIFDIGGSKGLPEYSVEKIPKITVTSDNNMDDSGERVSCSVCLQDFQLGETVRSLPQCHHMFHLPCIDKWLARSLKIFFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHU4</accession>
    <name>A0A103YHU4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHU4"/>
    <dbReference type="Gramene" id="KVI09372">
        <property type="protein sequence ID" value="KVI09372"/>
        <property type="gene ID" value="Ccrd_012232"/>
    </dbReference>
    <dbReference type="OMA" id="HHDNYLT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF125">
        <property type="entry name" value="CALCIUM-DEPENDENT CHANNEL, 7TM REGION PHOSPHATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="139"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="318"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="674" mass="76848" checksum="71169D823E69B2A0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIE7</accession>
    <name>A0A103YIE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_012007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIE7"/>
    <dbReference type="STRING" id="59895.A0A103YIE7"/>
    <dbReference type="Gramene" id="KVI09607">
        <property type="protein sequence ID" value="KVI09607"/>
        <property type="gene ID" value="Ccrd_012007"/>
    </dbReference>
    <dbReference type="OMA" id="QSIANHI"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048262">
        <property type="term" value="P:determination of dorsal/ventral asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000009">
        <property type="entry name" value="transcription factor MYB1R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042:SF15">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24818" checksum="D28FA65B7ED646C9" modified="2016-04-13" version="1">MQSTWTRYEDKLFEKALVDVPVGISGWWQMIADAVPGKTVEEVRAHYEELMRDLEEIESGRIEFPYYGDDYGRDSFMSWNSELKTSQISFESGKGSKPGEGPERKKGTPWTESEHRSFLVGMEKYGRGDWRSISRHSVITRTPTQVASHAQKYFIRQKTIKKQRKRSSIHDITTANAAMQPTSSTSLVGDKGGIVPPLAPRRPPLAPPPPPPSQSVYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK77</accession>
    <name>A0A103YK77_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_010989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001010">
        <property type="protein sequence ID" value="KVI10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK77"/>
    <dbReference type="STRING" id="59895.A0A103YK77"/>
    <dbReference type="Gramene" id="KVI10604">
        <property type="protein sequence ID" value="KVI10604"/>
        <property type="gene ID" value="Ccrd_010989"/>
    </dbReference>
    <dbReference type="OMA" id="AGMHPAC"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000146">
        <property type="entry name" value="Indole-3-glycerol phosphate synthase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001372">
        <property type="entry name" value="PRK00278.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="9">
        <location>
            <begin position="140"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="45518" checksum="157FE967D8F8D50B" modified="2016-04-13" version="1">MSCRITTFTVSNPNCSKLWSKKTSIKAFCSFRSLRVSVSGYPRGIGNSLLHSSSNSRFRLAASLELHGMKNEILVATPPSDSVVVDELKNKEWEIGVLKDEIAAMQGIRIRRTPPTGPPAHYVGTFEFLQNEDNTPRNKLEEIVWTKYVEVKEMKEKNALSSLKKALDNAPPLRDFIGSLKESYLRTGSPGLIAEVKKASPSRGVLRENFHPVEVAKAYEKGGAACLSVLTDEKYFQGSFENLVAIRNAGVKCPLLCKEFIVDAWQLYYARTKGADAVLLIAAVLPDIDIKYMLKICRKIGLAALVEVHDENEMDRMLAIDGIELIGINNRNLETFEVDISNTKKLLEGERGEKLRQKNIIVVGESGLFTPADIAYVQEAGVKAILVGESIVKQEDPTKGIRDLFGKDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKF5</accession>
    <name>A0A103YKF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000997">
        <property type="protein sequence ID" value="KVI10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKF5"/>
    <dbReference type="STRING" id="59895.A0A103YKF5"/>
    <dbReference type="Gramene" id="KVI10804">
        <property type="protein sequence ID" value="KVI10804"/>
        <property type="gene ID" value="Ccrd_010788"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933825at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053266">
        <property type="entry name" value="Zinc_finger_protein_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47593:SF8">
        <property type="entry name" value="OS12G0581900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47593">
        <property type="entry name" value="ZINC FINGER PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15730" checksum="8E7582FDF073F03A" modified="2016-04-13" version="1">MNSSGKDRVEDGDEQGWLNLSLGSNGLESATTSMIKVYTCSFCKRKFHNSQALGGHQNAHRRERDAARKYPAFHFHQSMEVHSSCLLQLVTPPGRGDGSETTTSTVARFINHGYGVTSVQNQRERSLEDFKSNTLDLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL42</accession>
    <name>A0A103YL42_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carotene isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000933">
        <property type="protein sequence ID" value="KVI11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL42"/>
    <dbReference type="STRING" id="59895.A0A103YL42"/>
    <dbReference type="Gramene" id="KVI11063">
        <property type="protein sequence ID" value="KVI11063"/>
        <property type="gene ID" value="Ccrd_010533"/>
    </dbReference>
    <dbReference type="OMA" id="VRGMQKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="536" mass="57375" checksum="DDA09B0589541D9A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL84</accession>
    <name>A0A103YL84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Isocitrate and isopropylmalate dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_010382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000797">
        <property type="protein sequence ID" value="KVI11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL84"/>
    <dbReference type="STRING" id="59895.A0A103YL84"/>
    <dbReference type="Gramene" id="KVI11210">
        <property type="protein sequence ID" value="KVI11210"/>
        <property type="gene ID" value="Ccrd_010382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="19952" checksum="9294FEF00BFC5EBB" modified="2016-04-13" version="1">MSSYLRYSPQDSPDMASTLVDSGKWMASSSTPPNNIVDAQNSTTPKTCNPYTRPLVSNDIDVTSQASMFWRKRIIAISAEYPDVELSHMYVDNGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEKKAADRVELAVLNALDMGLRTHDIYSLGNKLVGCKEMGEQVLKCLDAKTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNG5</accession>
    <name>A0A103YNG5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNG5"/>
    <dbReference type="Gramene" id="KVI12250">
        <property type="protein sequence ID" value="KVI12250"/>
        <property type="gene ID" value="Ccrd_009325"/>
    </dbReference>
    <dbReference type="OMA" id="KDGPNCR"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000009">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057444">
        <property type="entry name" value="Znf-CCCH_AtC3H23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF156">
        <property type="entry name" value="TRANSCRIPTION FACTOR C3H FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25512">
        <property type="entry name" value="zf-CCCH_AtC3H23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="39075" checksum="D947A7FC3116D411" modified="2016-04-13" version="1">MVGDGNQHGMMVHVPPWTTMMDDPVAGISPFSPRSPNAINSLTSMEDYAYFLRSDAALRRYLEEDLDGEGSGSGCTDFDITSEAYACDSFRMYEFKVRKCSRGRSHDWTDCPYAHPGEKARRRDPRKYSYSGTACPEFRKGNCKKGDGCEFAHGVFECWLHPHRYRTQPCKDGVNCRRRVCFFAHTPEQLRVVSPHTDSYDGSSLKTLPAFFSSPSETSTPPSDSPPMSPMDSSLSRSLGSVSVSDMLSSLRRLQLNKTPSMVTPWNLQMGRSLASPRSGFYSLPSTPTRPVTRGVGFSEIWEEEPAMERVESGRDLRAKMFEKLSKENGVDSPGEGPNPDVGWISELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNP8</accession>
    <name>A0A103YNP8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNP8"/>
    <dbReference type="STRING" id="59895.A0A103YNP8"/>
    <dbReference type="Gramene" id="KVI12491">
        <property type="protein sequence ID" value="KVI12491"/>
        <property type="gene ID" value="Ccrd_009136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48459">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48459:SF1">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="39064" checksum="957A1FA0E17CD63D" modified="2016-04-13" version="1">MGYQNAFEVEMVNHEDDSAVIVSSPQICGSQFLDLAIEEARNNKKTLISSMDSVIGFMKEVECEEEAAEQAKEEAAKYSLHILAKVDELKQAQQLAKETNAMVHAREVYAQKAVLATELEELQLRVSSLIKKELADNEKLENERFAREALAKVEEVVEESKRLKQEAVENSKELDLSFSSQTSILSSSSSLKFLGTPYEPRFEIMESLNTPDESIERGDSNVSHENSSDYLLVDSTVLSKNSSSNLENQDQNGSVCRKCRHSVNRIKKRIKVSKEKVILNMFRIKNLKNKAMKKWIELNKDAVTGFCQDDFATDYRADDFDDDKESDGCFNALRVDELEAAMEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I2G9</accession>
    <name>A0A118I2G9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007581">
        <property type="protein sequence ID" value="KVG81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I2G9"/>
    <dbReference type="STRING" id="59895.A0A118I2G9"/>
    <dbReference type="Gramene" id="KVG81711">
        <property type="protein sequence ID" value="KVG81711"/>
        <property type="gene ID" value="Ccrd_026183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159311" evidence="3">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="36891" checksum="E60197155E18164C" modified="2016-04-13" version="1" fragment="single">LSSALKHVFGLLIGLRACSQFTYSISCGTPSFYGFVAKPNGIVLVSRDYQSSSELKGLPIVGVEGITFRLCLSSPSPSLAAAQAFRLCLPSPSPALAAAQAFRLYLLSPSPALAAAQTFRLCLLSPSPASIDVLFRQALLSFSRCRRRSSGNVFWVMGNGLRRKMPCSGGNGLGMPSEGAAETGRRLANYCERFKVSFEYNTIETQNWEIVKIEDLKLQRNECLANLLDNTVVVNSPRDSVLKMIRDMKPDIFIQMFDIQKEIESLKALVVDFQEDKDMQAIACEELQQVLKEEQCVHNFLLKSLLPEKQYYKWILECNFHDMNKGVHGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTR2</accession>
    <name>A0A118JTR2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AMP-binding, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005096">
        <property type="protein sequence ID" value="KVH90732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTR2"/>
    <dbReference type="STRING" id="59895.A0A118JTR2"/>
    <dbReference type="Gramene" id="KVH90732">
        <property type="protein sequence ID" value="KVH90732"/>
        <property type="gene ID" value="Ccrd_007234"/>
    </dbReference>
    <dbReference type="OMA" id="ENICLCF"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106286">
        <property type="term" value="F:(E)-caffeate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050563">
        <property type="term" value="F:trans-feruloyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05904">
        <property type="entry name" value="4CL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF425">
        <property type="entry name" value="4-COUMARATE--COA LIGASE-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="574"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116894" checksum="D81EE5BBAEE644C0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU16</accession>
    <name>A0A118JU16_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005053">
        <property type="protein sequence ID" value="KVH91301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU16"/>
    <dbReference type="Gramene" id="KVH91301">
        <property type="protein sequence ID" value="KVH91301"/>
        <property type="gene ID" value="Ccrd_006683"/>
    </dbReference>
    <dbReference type="OMA" id="KFDTMIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="622" mass="70360" checksum="7CBA0C1524418EEA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUH3</accession>
    <name>A0A118JUH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Brevis radix-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_006469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004933">
        <property type="protein sequence ID" value="KVH91509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUH3"/>
    <dbReference type="STRING" id="59895.A0A118JUH3"/>
    <dbReference type="Gramene" id="KVH91509">
        <property type="protein sequence ID" value="KVH91509"/>
        <property type="gene ID" value="Ccrd_006469"/>
    </dbReference>
    <dbReference type="OMA" id="QETEWIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013591">
        <property type="entry name" value="Brevis_radix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044532">
        <property type="entry name" value="BRX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058:SF37">
        <property type="entry name" value="DZC DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08381">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51514">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="279"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH91509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="37681" checksum="E3346B4CFBAF61F0" modified="2016-04-13" version="1">MLTCITCSKQQIEDGGEEVGARGTPSSKEAVKSLTAQIKDALKVSGSSKGKPPIGPSSYKKGQRAYPDFETISEGVNYPYMQPGSSSSTPAWDFTSNEPSGGYEPPRQSGHLVLEDEDEPKEWMAQVEPGVQITFVSLPNGGNDLKRIRFNREMFNKWQAQRWWGENYDRIMELYNVQRFNCQALNTPSRSEDGRDSTYSRLGSARESPMMTPSVNKDWNRNYYKSSDQGGNHQFNVGPSAYGGSGPKGEVSSMEASRTTTSSRDEASISVSNASDMESEWIEQDEPGVYITIRQLTDGTRELRRVRFSREKFGEVHAKQWWEENRERIQTQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUV6</accession>
    <name>A0A118JUV6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUV6"/>
    <dbReference type="STRING" id="59895.A0A118JUV6"/>
    <dbReference type="Gramene" id="KVH91797">
        <property type="protein sequence ID" value="KVH91797"/>
        <property type="gene ID" value="Ccrd_006169"/>
    </dbReference>
    <dbReference type="OMA" id="PDISIMP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35751">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35751:SF3">
        <property type="entry name" value="OS06G0530200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16143" checksum="B09429C5401F9F9A" modified="2016-04-13" version="1">MAIITKFHYFFSLFFKQRKPLPKSQPQKVTSLRSPPPSSRPPPPPPPPPIGRDMGAAQAMKRIPRIKFPQRHPKPSGSTTQNQAAAPVAGDVPSAFFSRSAPSEKTLGGKASLQPKRTPMSQEEIDAILVCSSFSFACLYSPDISIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVV8</accession>
    <name>A0A118JVV8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004532">
        <property type="protein sequence ID" value="KVH94702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVV8"/>
    <dbReference type="STRING" id="59895.A0A118JVV8"/>
    <dbReference type="Gramene" id="KVH94702">
        <property type="protein sequence ID" value="KVH94702"/>
        <property type="gene ID" value="Ccrd_003229"/>
    </dbReference>
    <dbReference type="OMA" id="EPICLCE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="242" mass="24855" checksum="EE315A0E0D4294E1" modified="2016-04-13" version="1">MLSNHLHHSLYIHTYKSMPFLHSSIPSISIFHPPLPSPGRHHRCFPPMANTNTTIMATAILVALVFTAVPCLAAQSPRGSPMMSPTSPTTMGPAPDCMTALYNVSDCLSFVQVGSNMTAPDKACCPEFAGLLESNPICLCDLIGSSESFGVDLSRALMLPDACKLETPSISSCPATPTSAPEPSPTGEAPGSTAAGAVPNGGAAPGPVGSGTGGSNGASSTTVHDLSTFVCLAVAIFIAYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWL2</accession>
    <name>A0A118JWL2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWL2"/>
    <dbReference type="STRING" id="59895.A0A118JWL2"/>
    <dbReference type="Gramene" id="KVH94362">
        <property type="protein sequence ID" value="KVH94362"/>
        <property type="gene ID" value="Ccrd_003577"/>
    </dbReference>
    <dbReference type="OMA" id="ECYDLPP"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="OB" evidence="9">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="169" mass="19110" checksum="AB1D13FBC4742FD5" modified="2016-04-13" version="1">MEALHDTHVKLLAFDLLSLTPSSSNPNAVYRKGTLLLSRVETLGVVTSRDHKPDRFLRFTIDDGTGCIPCVLWLNQLTSPYFSRRSPPDVRLIAEAARKFATLIQIGVSARVRGKVTFYRGNLQLTVSNVFIERDPNAETLHWLQCVRLARKCYDIVPDPTPVYKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXG2</accession>
    <name>A0A118JXG2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004345">
        <property type="protein sequence ID" value="KVH96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXG2"/>
    <dbReference type="STRING" id="59895.A0A118JXG2"/>
    <dbReference type="Gramene" id="KVH96222">
        <property type="protein sequence ID" value="KVH96222"/>
        <property type="gene ID" value="Ccrd_001688"/>
    </dbReference>
    <dbReference type="OMA" id="RFQLHYP"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071452">
        <property type="term" value="P:cellular response to singlet oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF36">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTEF1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="34792" checksum="AED9592CD28DE947" modified="2016-04-13" version="1">MIIRFLHVPPIPQSSQNPTKIHHNTLKKTSVSPKNGVLTATAPPPLVTTDSGLRFREKILYLKSLKVNPAKALHRNPNFRSTSLQSLKSVEKCLSSMGIERSEFGRIFDMFPQLLTCDPDTDLYSVFGFLLDDVGLHFFDIRKSILRCPRLLICSVEDQLKPTLWFLRKLGFMGSSKITSQTTMLLVSSVKSTLMPKLDYLMGLGFEYEEVANMVLRSPGLLTFSIENNFKPKVEFFLNEMKGDLGDLKKFPQYFSYSLEGKIKRRHRLLVDQGVSVPLWEMLKVSDGEFTARLIEARLRLGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXU7</accession>
    <name>A0A118JXU7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXU7"/>
    <dbReference type="Gramene" id="KVH95995">
        <property type="protein sequence ID" value="KVH95995"/>
        <property type="gene ID" value="Ccrd_001945"/>
    </dbReference>
    <dbReference type="OMA" id="KTFSFMH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000525">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000755">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF386">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="46230" checksum="A8A4A98ED739EE30" modified="2016-04-13" version="1">MSYTLQTDLVYAYTKCSQENNIQTLTKFFNCSILTHPVPFNSLLSGFVKNGNPLVALKTLSLMNVNGVPIDTYALCSSLTACCLIPSVGFGKQIHTHVVKSGWGSSVFIGSALVDFYSKSVAVVDAAKVFDEIPLKNTVCANALLSAYSDAKMWANGLELFRIMPGFNLCYDNWTFSVALSICAGLYAIELGSQVHAKVIRTICDAGTDVFLLSSLIDLYGKCGLVTKARQVFSMAAFADVVLWTSMLGVYGRNGHHKDVIRLFKKMLTKKVRPDGVAFVSVISACGHTGQVDLGTEYFESMARDFGLNPSPEHYGCLVDLFCRAGELENAWKVVDKMPNKASAGISVWGALLSACCDQGHVDLGKFAARRALELDPMNTGVYVLLSNMYAKCGLWDEIGDLRESMRDKGLKKDIGRSWIGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0I1</accession>
    <name>A0A118K0I1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA mismatch repair protein MutS, connector domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_020458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003122">
        <property type="protein sequence ID" value="KVI01273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K0I1"/>
    <dbReference type="Gramene" id="KVI01273">
        <property type="protein sequence ID" value="KVI01273"/>
        <property type="gene ID" value="Ccrd_020458"/>
    </dbReference>
    <dbReference type="OMA" id="IKNICHP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="547"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="817"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="997" mass="110166" checksum="05323ADD49C5E482" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Q7</accession>
    <name>A0A118K0Q7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C48, SUMO/Sentrin/Ubl1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002692">
        <property type="protein sequence ID" value="KVI01742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Q7"/>
    <dbReference type="Gramene" id="KVI01742">
        <property type="protein sequence ID" value="KVI01742"/>
        <property type="gene ID" value="Ccrd_019979"/>
    </dbReference>
    <dbReference type="OMA" id="AMETSYD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="28218" checksum="A349F9C2359B4D6C" modified="2016-04-13" version="1">MVLNREERLRSNESPRRYFVQTDISMDAIIRDEDLNVNQMYDRFRKNITSCMNTDKELINMRNVDLVFFPVVEPSFYYVLVFDLKRPSIAILDSQNRDGKVDDIYGSSTVGLQDMMIMHLLKEGHGAWKVYAEMDQDHIKTRWQFRENTVDAGVMLMRHMETFFGGDVMKWECGLYKEGTKQKRQLKDLRTKYCSKMLLSDENIRKTSIVSDVERFIAMETSYDARKNRGARLMSRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2H1</accession>
    <name>A0A118K2H1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002210">
        <property type="protein sequence ID" value="KVI04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2H1"/>
    <dbReference type="STRING" id="59895.A0A118K2H1"/>
    <dbReference type="Gramene" id="KVI04353">
        <property type="protein sequence ID" value="KVI04353"/>
        <property type="gene ID" value="Ccrd_017334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000111">
        <property type="entry name" value="p-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF50">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-14P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="178"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="463" mass="52552" checksum="B17CE343B21E3418" modified="2016-04-13" version="1">MFQTENTNSHEEKQNEEQDVERIMEEKDSKSAEIAALKQELEKARKKHEEHCLQIEAAGRKAQVGLEEKLREVESLLNKSKMKVQELEANSQSKMHWWNKKEHIYKTFTEFQLGALKELRFASQSVRQEFLKSQKTYSEDFDRLGTKVKVLQDAAESYQVAISENRKLHNEIQELKGNIRVYCRIRPFLPGQKDKQTTVDYIGENGEIIIVNPSKPGKESRRSFKFNKVYGPRATQAEVYGDIQQLIRSVLDGYNVCIFAYGQTGAGKTYTMSGPDNGSEEDWGVNYRALNDLFKISQISAQNSGLAVPDANMRQVNEPSDVMGVMEIGFKNRARSTTAMNERSSRSHSCLMWICMHSVVTIHVHGTELQTGVSLHGSLHLVDLAGSERIDRSEVIGDRLKEAQHINKSLAALGDVFFSLSQKSVHVPFRNSKLTQVLQSSLGNLLFPSLFCMFSYTFVIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2T9</accession>
    <name>A0A118K2T9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ran GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001901">
        <property type="protein sequence ID" value="KVI04892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2T9"/>
    <dbReference type="STRING" id="59895.A0A118K2T9"/>
    <dbReference type="Gramene" id="KVI04892">
        <property type="protein sequence ID" value="KVI04892"/>
        <property type="gene ID" value="Ccrd_016783"/>
    </dbReference>
    <dbReference type="OMA" id="MGHRIEN"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24191" checksum="E047098ED430BF13" modified="2016-04-13" version="1">MAYKVDHEYDYLFKIVLIGDSGVGKSNILSRFTRNEFLLESKSTIGVEFATRTLQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDITKGQTFENVLRWLRELRDHADSNIVIMLAGNKSDLNHLRVVQESDGQRLAEQEGLSFLETSALEAHNVEKAFQMILLDIYHIVSKKALAAQEAAKASAVPSQGTTINVVDYGNKPQRKGCCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2Y8</accession>
    <name>A0A118K2Y8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2Y8"/>
    <dbReference type="STRING" id="59895.A0A118K2Y8"/>
    <dbReference type="Gramene" id="KVI05085">
        <property type="protein sequence ID" value="KVI05085"/>
        <property type="gene ID" value="Ccrd_016606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="182" mass="19929" checksum="F1B5C2D23E017D0E" modified="2016-04-13" version="1">MAMPRNRRTTSLRDSDSRLGDSDKIEGAGSWDAIEWTKIDQPVSRPVPHGLSDFLYEAEEVLAEGYGVLVNTDEAGTLFVTSFRLLFLSEGSRDIIALGTIPLATIEKFNKIKKMNCYNTNFVPNTQGVGETQVQAMPMTLLVPSHAHLPEGRESAWTSEKCPAVVRSLTNISSLSVCPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K322</accession>
    <name>A0A118K322_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001879">
        <property type="protein sequence ID" value="KVI05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K322"/>
    <dbReference type="STRING" id="59895.A0A118K322"/>
    <dbReference type="Gramene" id="KVI05313">
        <property type="protein sequence ID" value="KVI05313"/>
        <property type="gene ID" value="Ccrd_016351"/>
    </dbReference>
    <dbReference type="OMA" id="HRKQTMN"/>
    <dbReference type="OrthoDB" id="1917565at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF202">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="37905" checksum="1E6C3C459CA6708F" modified="2016-04-13" version="1">MNHESPCSKKSRSRAMFMDPNKPLRRIRVICYDPDLTDSSDDDEPNKKPYGSKRIVREITIPVGHGGVPVAAGGWTETGTTKETETESSCQDSNNGEKSSGKRKRVLTRNSGQPRPASASKYRGVRQRKWGKWAAEIRDPFKQRRVWLGTYNTAEEASRAYEIKKLEFEAMAEASKGGSNNVKNTTGKTISSAAVSQPPKPAVSEESVGVISHNSPLSVLEPETSSISKKINDSTAASQTSNGETKIEAPSTVMSSVVEEALTLAEIGEGLDMKLELDSMFLDDFGPPLDGFGDLDDFQFCGFEDEEACELPDWDFEELNPEEVAWMNTLRVDEQQQPLNIACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3F3</accession>
    <name>A0A118K3F3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001860">
        <property type="protein sequence ID" value="KVI05863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3F3"/>
    <dbReference type="STRING" id="59895.A0A118K3F3"/>
    <dbReference type="Gramene" id="KVI05863">
        <property type="protein sequence ID" value="KVI05863"/>
        <property type="gene ID" value="Ccrd_015797"/>
    </dbReference>
    <dbReference type="OMA" id="EICAVAW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009867">
        <property type="term" value="P:jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="160" mass="17920" checksum="EDBA2E580434EFE0" modified="2016-04-13" version="1">MGVKVLSHFQERGITVFSSLDHLSLPTQVFPGDFWLPSMDSDVTMVLASDASSLPGPSSSSPVASSSSKKPKRFEIKKWNAVSLWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNSEWEFQKYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3M3</accession>
    <name>A0A118K3M3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Geranylgeranyl diphosphate reductase, chloroplastic</fullName>
            <ecNumber evidence="3">1.3.1.83</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranyl reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_015501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>phytyl diphosphate + 3 NADP(+) = geranylgeranyl diphosphate + 3 NADPH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:75434"/>
            <dbReference type="EC" id="1.3.1.83"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; tocopherol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geranylgeranyl reductase family. ChlP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.83" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001847">
        <property type="protein sequence ID" value="KVI06153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3M3"/>
    <dbReference type="STRING" id="59895.A0A118K3M3"/>
    <dbReference type="Gramene" id="KVI06153">
        <property type="protein sequence ID" value="KVI06153"/>
        <property type="gene ID" value="Ccrd_015501"/>
    </dbReference>
    <dbReference type="OMA" id="YPVQCAG"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102067">
        <property type="term" value="F:geranylgeranyl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045550">
        <property type="term" value="F:geranylgeranyl reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000083">
        <property type="entry name" value="Geranylgeranyl diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010253">
        <property type="entry name" value="BchP_ChlP_pln/prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011774">
        <property type="entry name" value="Geranylgeranyl_Rdtase_pln/cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02023">
        <property type="entry name" value="BchP-ChlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02028">
        <property type="entry name" value="ChlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF13">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="42"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI06153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="451" mass="49540" checksum="5DF772B66352E308" modified="2016-04-13" version="1">MAAIAHPLHSLTFTSKSPTPRFKPFPKLVISASNKPISGRKLRVAVIGGGPAGSSAAESLASGGVETYLFERSPTGAKPCGGAIPLCMLDEFSIPPELVDRKVTHMKIVSPSNLTVDFGKTLKSNEYISMLRREVLDSFLRSRAESKGAILLKGLVTNLDLPNFPNQPYIIHYTVNNTIKYLPVDVVVGADGANSRVAKSIDAGDYACAIAFQERIRLPDDKMEYYHNLAEMYIGNDVSPDFYAWVFPKCDHVAVGTGTVISKPNIKQFQKAIRSRVLPKIAGGTVIKVEAHPIPEHPRPVRVRGRVALVGDAAGYVTKCSGEGIYFAAKSGRMCGEGIVKASEGGQKMIEESDLKREYLKQWDSQYINTFKFLDLLQHVFYGSNAAREALVELCGDEYVQRMTFESYLYKKLANGNPWEDFKMVSNTIGSLMRCKLVGKGMEAFDPNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K458</accession>
    <name>A0A118K458_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001537">
        <property type="protein sequence ID" value="KVI06962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K458"/>
    <dbReference type="STRING" id="59895.A0A118K458"/>
    <dbReference type="Gramene" id="KVI06962">
        <property type="protein sequence ID" value="KVI06962"/>
        <property type="gene ID" value="Ccrd_014680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="86" mass="9817" checksum="DF5A48D63F54660B" modified="2016-04-13" version="1">MTRDGGFKEMRLHIWPDRTSSTRDVGDTLPISEKANVPDEEQMNGGRYRSKAELRKKNRRMKNGPGRNQSTGGRVDKCEGFSSKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4I3</accession>
    <name>A0A118K4I3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltose excess protein 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4I3"/>
    <dbReference type="STRING" id="59895.A0A118K4I3"/>
    <dbReference type="Gramene" id="KVI07560">
        <property type="protein sequence ID" value="KVI07560"/>
        <property type="gene ID" value="Ccrd_014093"/>
    </dbReference>
    <dbReference type="OMA" id="WRFWEDL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005363">
        <property type="term" value="F:maltose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034628">
        <property type="entry name" value="MEX1/MEX1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34809">
        <property type="entry name" value="MALTOSE EXCESS PROTEIN 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34809:SF1">
        <property type="entry name" value="MALTOSE EXCESS PROTEIN 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48684" checksum="156736CFD6FE4194" modified="2016-04-13" version="1">MTGGSVAVLGGTPPPIQPLTPTRCSCNNGRVFLHHPHFSNPSILPLKRSPFNTLKLGAPSSSSVNPSFRLKKRSRFRPKNPALDSDIPSPIHQEDNDQEEISKKNLQQWDSLTAKFAGAANVPFLLLQLPQIVLNARNLIAGNNAALFAVPWLGMFTGLLGNLSLLSYFAKKRETEVVVVQTLGVVSTYAVITQLAMAGSMPLPQFAATSIVVACGLLINFLYFFKLLNHIIWNFWEDFITVAGLSALPQVIYLLGFLLVMWSTFVPYVPNSILPGIVSFLMAVIAVVMLHDMNLQARIGKLPEKATKFVGSVSGWTATLLFMWMPVAQMWTNFLNPDNIRGLSSISMLLAMMGNGLLIPRALFVKDLMWFTGSCWASFFYGWGNLICMYLVCAMEGYECVWPRIATYFFKGVIFWSLEHSHSYDVLQIFCGGAWKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K529</accession>
    <name>A0A118K529_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001118">
        <property type="protein sequence ID" value="KVI08461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K529"/>
    <dbReference type="Gramene" id="KVI08461">
        <property type="protein sequence ID" value="KVI08461"/>
        <property type="gene ID" value="Ccrd_013167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="66" mass="7459" checksum="4E05874143B30F99" modified="2016-04-13" version="1">MAQFNKGKTKCLKFCSSPDEKILEEDFKDAKTKHKFGKGCKSSNLEKEIKELGLQYIKKEANSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5C1</accession>
    <name>A0A118K5C1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_012798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001087">
        <property type="protein sequence ID" value="KVI08833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5C1"/>
    <dbReference type="STRING" id="59895.A0A118K5C1"/>
    <dbReference type="Gramene" id="KVI08833">
        <property type="protein sequence ID" value="KVI08833"/>
        <property type="gene ID" value="Ccrd_012798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048262">
        <property type="term" value="P:determination of dorsal/ventral asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044636">
        <property type="entry name" value="RADIALIS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952:SF75">
        <property type="entry name" value="PROTEIN RADIALIS-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI08833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="18476" checksum="B357C9F928656F39" modified="2016-04-13" version="1">MASNSLYSSSSSSSWTPQQNKLFERALAVYDRDTPDRWQKIARAVGGKSAEEVKRHYEVLIEDLRHIESGNVPFPNYRRWLMIVLLANLKFGTGLVHLKSYRGKSIAHDESCLFTDMGEKEQKFPLRKTSARRQVARCSVSLTEIIFTATSSVPTSPQLSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7A9</accession>
    <name>A0A118K7A9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Channel protein in tonoplast. These proteins may allow the diffusion of amino acids and/or peptides from the vacuolar compartment to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000021">
        <property type="protein sequence ID" value="KVI11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7A9"/>
    <dbReference type="STRING" id="59895.A0A118K7A9"/>
    <dbReference type="Gramene" id="KVI11985">
        <property type="protein sequence ID" value="KVI11985"/>
        <property type="gene ID" value="Ccrd_009592"/>
    </dbReference>
    <dbReference type="OMA" id="IGQNTHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000002">
        <property type="entry name" value="Probable aquaporin TIP1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF32">
        <property type="entry name" value="AQUAPORIN TIP1-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="23594" checksum="A676F68FF0EC636F" modified="2016-04-13" version="1">MPISSIAIGTPADASSPDALKAALAEFISMLIFVFAGEGAGMAFATPAGLISASIAHAFALFVAVSVGANISGGHVNPAVTFGAFVGGHISLLRSVLYWIAQCLGSVVACLLLKIATGGEWNAVAFEIVMTFGLVYTVYATAVDPKKGDLGIIAPLAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWNSHWVYWLGPFAGAAIAALVYEVIFIGSSTHEPLPITDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7M5</accession>
    <name>A0A118K7M5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_009091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family. SR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7M5"/>
    <dbReference type="STRING" id="59895.A0A118K7M5"/>
    <dbReference type="Gramene" id="KVI12508">
        <property type="protein sequence ID" value="KVI12508"/>
        <property type="gene ID" value="Ccrd_009091"/>
    </dbReference>
    <dbReference type="OMA" id="DHRSHER"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12599">
        <property type="entry name" value="RRM1_SF2_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12602">
        <property type="entry name" value="RRM2_SF2_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000410">
        <property type="entry name" value="ASF/SF2-like pre-mRNA splicing factor SRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000062">
        <property type="entry name" value="serine/arginine-rich splicing factor SR34A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="33262" checksum="C67861BC25616868" modified="2016-04-13" version="1">MSRSSRTLYVGNLPGDIREREVEDLFYKYGPIAHIDLKIPPRPPGYAFVEFEEARDAEDAIRGRDGYDFDGHRLRVELAHGGRGNSSSTDRYSSHGGGRGGSGGGRGGGVSRRSDYRVMITGLPSSASWQDLKDHMRRAGDVCFSQVFREGGGTTGIVDYTNYDDMKYAIRKLDDSEFRNAFSRGVIRVKEYDSSHSRSRSRSRSKSRGYSKSRSRSRSKSPKVKSSRRSRSHSRSGSPRSRSGSKPRSLSRSPSRSRSPLPSRPKRVSKSPKRRSPSKSRSPSRSRSRSRSKSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAR5</accession>
    <name>A0A124SAR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_024113</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005448">
        <property type="protein sequence ID" value="KVH88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAR5"/>
    <dbReference type="STRING" id="59895.A0A124SAR5"/>
    <dbReference type="Gramene" id="KVH88330">
        <property type="protein sequence ID" value="KVH88330"/>
        <property type="gene ID" value="Ccrd_024113"/>
    </dbReference>
    <dbReference type="OMA" id="HTCLETS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000129">
        <property type="entry name" value="cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000142">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000002">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF929">
        <property type="entry name" value="GNK2-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176099" evidence="18">
        <location>
            <begin position="24"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="296"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="617" mass="69001" checksum="E457C0E7C5AFBAAB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBB3</accession>
    <name>A0A124SBB3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MIZU-KUSSEI 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBB3"/>
    <dbReference type="STRING" id="59895.A0A124SBB3"/>
    <dbReference type="Gramene" id="KVH90082">
        <property type="protein sequence ID" value="KVH90082"/>
        <property type="gene ID" value="Ccrd_007922"/>
    </dbReference>
    <dbReference type="OMA" id="DPHHNTS"/>
    <dbReference type="OrthoDB" id="672310at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010274">
        <property type="term" value="P:hydrotropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006460">
        <property type="entry name" value="MIZ1-like_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01570">
        <property type="entry name" value="A_thal_3588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696:SF4">
        <property type="entry name" value="OS08G0171800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696">
        <property type="entry name" value="PROTEIN MIZU-KUSSEI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04759">
        <property type="entry name" value="DUF617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26322" checksum="FA9E5DFE7E328969" modified="2016-04-13" version="1">MGEPIDSNHDMTTKPNPLRPPPPPPPYPPLKAHRQSSKKKNRPKVFRVVRSVFRSFPVKTKRFPFYSSHFSGGSSSDHVTATLFGYRNGGVSLCIQENPYAFPVLILEMGLETSMLEKEMSMGFVRIVLECENKETMRLVEEPSWTVYCNGKKSGYGVKREATEEDLGVMEKLQPMSTGTGALPGKSDVEGGDCEMAYVRTHFDRVVGSKDSKTLYMVSSDRNNGPELSIFFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBJ1</accession>
    <name>A0A124SBJ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_007198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005093">
        <property type="protein sequence ID" value="KVH90790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBJ1"/>
    <dbReference type="STRING" id="59895.A0A124SBJ1"/>
    <dbReference type="Gramene" id="KVH90790">
        <property type="protein sequence ID" value="KVH90790"/>
        <property type="gene ID" value="Ccrd_007198"/>
    </dbReference>
    <dbReference type="OMA" id="GQQNFQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH90790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="35169" checksum="24484B80AFD4A6FB" modified="2016-04-13" version="1" fragment="single">PTNVKRAPQIGDIHEKQREENTRWRGTTKNVEVANKHKYQQRGFTVLAQYCINSMSSTAMQANSADSSSPEQSLDRDSQSDEVLSEEEDDVSKETHDVPYFPSGAFQITLLIIIHSSASHVSVTPNETREIQYGKTSRGHFTLNHVYSYLNIDDKFHPSVSDSYGQGQQNFQHGAPNILPRNEETVAQAPQPELVGHSVPYLHESRHQHAMRRVRSSGGRFAKKTETNASEDKKATGSGASGMKRMQSGQSGESFSETRGGVVNSCNGRTYAVDGGGRYDNQDGFQGSSYHSDIGEGGSLGQQWATMPANQGSQRAVAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBT0</accession>
    <name>A0A124SBT0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004916">
        <property type="protein sequence ID" value="KVH91615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBT0"/>
    <dbReference type="STRING" id="59895.A0A124SBT0"/>
    <dbReference type="Gramene" id="KVH91615">
        <property type="protein sequence ID" value="KVH91615"/>
        <property type="gene ID" value="Ccrd_006371"/>
    </dbReference>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="28841" checksum="5EC5D157EA903EFF" modified="2016-04-13" version="1" fragment="single">GASLIGQIPPPSLPLFSIPLFSPFSFNQSNTFFCPLSVVMSLFGLGRNQRTFRPKKSAPSGSKGAQLRKHIDATLGSGNLREAVRLPPGEDINEWLAVNTVDFFNQVNLLYGTLTEFCTPESCPTMTAGPKYEYRWADGVQIKKPIEVSAPKYVEYLMDWIESQLDDESIFPQKLGAPFPHNFRDVVKTIFKRLFRVYAHIYHTHFQKIVSLKEEAHLNTCFKHFILFTCEFGLIDNKELAPLQELIESIVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD78</accession>
    <name>A0A124SD78_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">xyloglucan:xyloglucosyl transferase</fullName>
            <ecNumber evidence="1">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>breaks a beta-(1-&gt;4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan.</text>
            <dbReference type="EC" id="2.4.1.207"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01004362">
        <property type="protein sequence ID" value="KVH96067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD78"/>
    <dbReference type="Gramene" id="KVH96067">
        <property type="protein sequence ID" value="KVH96067"/>
        <property type="gene ID" value="Ccrd_001847"/>
    </dbReference>
    <dbReference type="OMA" id="TILWNSH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044042">
        <property type="term" value="P:glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="75"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="318"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="593"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="929" mass="103845" checksum="96924A952DBFDB2A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDG1</accession>
    <name>A0A124SDG1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004160">
        <property type="protein sequence ID" value="KVH96820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDG1"/>
    <dbReference type="STRING" id="59895.A0A124SDG1"/>
    <dbReference type="Gramene" id="KVH96820">
        <property type="protein sequence ID" value="KVH96820"/>
        <property type="gene ID" value="Ccrd_001088"/>
    </dbReference>
    <dbReference type="OMA" id="NFPTHED"/>
    <dbReference type="OrthoDB" id="1931494at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006952">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_sf"/>
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        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF228">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25405" checksum="E089A92ECC7E81C8" modified="2016-04-13" version="1">MAPKERSAGAGKPNTTGVGGVSLKEPHFRGVRKRPWGRYAAEIRDPGKKSRVWLGTFDTAEEAARAYDAAAREFRGAKAKTNFPTHEDVGLFKVQRSPSQTSTVESPSHPEPVVPLLDLNLSYSVPPPFVVHFPYHHQNQHRFSKVPGAGFYSPPANQMVYFDGIHITNCDRSPVIFRQSSSASKSDDSNSSTVVNLKPSPPPRRIAIDLNFPPPAEGLDIDLNHQIVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDL1</accession>
    <name>A0A124SDL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003841">
        <property type="protein sequence ID" value="KVH97285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SDL1"/>
    <dbReference type="Gramene" id="KVH97285">
        <property type="protein sequence ID" value="KVH97285"/>
        <property type="gene ID" value="Ccrd_000609"/>
    </dbReference>
    <dbReference type="OMA" id="DHEHWHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000013">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000046">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058920">
        <property type="entry name" value="PAP-OAS1-bd-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058921">
        <property type="entry name" value="PAP/OAS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979:SF30">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979">
        <property type="entry name" value="PAP/OAS1 SUBSTRATE-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26180">
        <property type="entry name" value="PAP-OAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="40"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PAP/OAS1 substrate-binding-related" evidence="3">
        <location>
            <begin position="173"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1338" mass="147543" checksum="30EB06BF0CD93710" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SER8</accession>
    <name>A0A124SER8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="7">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_020775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Probably involved in membrane trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
            <location evidence="7">Secretory vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003155">
        <property type="protein sequence ID" value="KVI00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SER8"/>
    <dbReference type="Gramene" id="KVI00963">
        <property type="protein sequence ID" value="KVI00963"/>
        <property type="gene ID" value="Ccrd_020775"/>
    </dbReference>
    <dbReference type="OMA" id="FAYYVFL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF75">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="36702" checksum="A0AB256011858F0D" modified="2016-04-13" version="1">MAGRFDPNPFDEGDEVNPFAVSYKFLRINLLGIIFLCVRLLVLPCSTFLLFPYNQDNGAGGKGAGKTNFGGGPFYTTSVPSAANSRLSPLPHEPADFYDRSAPVDIPLDSAADLKKKERELQAREADLRKREDIVKRKEEAAARAGIVLEEKNWPPFFPIIHHDIANEIPIHLQKLQYVAFTTYLAGLVLCLLWNIIATTTAWIKGEDPKIWFLALIYFISGVPLAYVLWYRPLYRAFSCVIIVMVLDLPSPSHHLFRILCHQVHIAFVIFAAVAPPVVFKGKSLAGILPAVDLVGDHALVGQVYMYFRGSGHAAEMKREVARSAVRAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFT2</accession>
    <name>A0A124SFT2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002298">
        <property type="protein sequence ID" value="KVI04201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFT2"/>
    <dbReference type="STRING" id="59895.A0A124SFT2"/>
    <dbReference type="Gramene" id="KVI04201">
        <property type="protein sequence ID" value="KVI04201"/>
        <property type="gene ID" value="Ccrd_017488"/>
    </dbReference>
    <dbReference type="OMA" id="AMFTHGL"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051504">
        <property type="entry name" value="Plant_metabolite_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31625">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="447" mass="49177" checksum="942D2561E46FA148" modified="2016-04-13" version="1">MASLPIFTVLEQSQVSPPPATVGHRSLPLTFFDIGWLSQPPVHHLFFYELAITKPQFIETIVPTLKRSLSITLQHFFPFVGNLIIFPTRKPEIRHVDGDSVAVTFAESNLDFHDLTGNHARDCGSFYPLIPVLGHAAQASADYVSITVFSVQVTVFPGCGISIGMTNHHCLGDASTRSCFLKAWTSIARSGTDESFLGSGALPLYDRVIKQPTLDEIYLKQANIGTFTQEYQPASLSGPTNNVRATFVLTRPTINRLKKRVSNQLPSLQYVSSFTVACAYIWSCMAKIRGDELQVFGFVIDCRSRLVPAIPATYFGNCVAPCGAMARTTVLSERDGFVTAARLLGESLHEKLTDKDGILKDAESWYELSFGGVPDTIMGVAGTPKIRFYDTDFGWGKPRKYEIISIDYNGSISMNACKDSNEDLEIGVCLSATEMKAFVSMFNCGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG85</accession>
    <name>A0A124SG85_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sin3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001867">
        <property type="protein sequence ID" value="KVI05611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG85"/>
    <dbReference type="STRING" id="59895.A0A124SG85"/>
    <dbReference type="Gramene" id="KVI05611">
        <property type="protein sequence ID" value="KVI05611"/>
        <property type="gene ID" value="Ccrd_016067"/>
    </dbReference>
    <dbReference type="OMA" id="HEFEDEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF65">
        <property type="entry name" value="HISTONE DEACETYLASE INTERACTING DOMAIN, SIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sin3 C-terminal" evidence="1">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="49193" checksum="7AA3B178DB2AB74B" modified="2016-04-13" version="1" fragment="single">MALECVKVTIELAEKLVMMISDKSIEIDGLFPVEEYFSGPSLRCIKVLYGDYGLNVIKELRTDVSLSLPRILSRLKQKKEEWRMFSSGFNKLWKPVFAVNHEMSLDHQDAYLEQQDSKFLSNNDLLAEINGINKLEFVYSDMDIHKDLYQLIEQSCSDICSSEQLDRAMKIWTSLVESMFGLLLRSAGCTDDSKHIAETRISNEQIMNYNAPITNEPEGTRGQEGTDGFLEFLTNEIDFSPIVDLEKGGFAAHMHNIEQNYDQEGVLGSEAVADNAVEETSSNDRENVDIVQEEDRSLIFYGDDAFYVFFRLHQALYGRLEEAKRLANDSYPVFLDLLHNYLTGAYKDKFENECRTIFGNSSGLIFSIERLINKLSRQLRAVTMNEVDNKLLDLYASEKTRESGRFVDEVYAANARSIVTTYKMFRFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGC5</accession>
    <name>A0A124SGC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_015709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the early nodulin-like (ENODL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGC5"/>
    <dbReference type="STRING" id="59895.A0A124SGC5"/>
    <dbReference type="Gramene" id="KVI05957">
        <property type="protein sequence ID" value="KVI05957"/>
        <property type="gene ID" value="Ccrd_015709"/>
    </dbReference>
    <dbReference type="OMA" id="VYSHWAS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11019">
        <property type="entry name" value="OsENODL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000010">
        <property type="entry name" value="Early nodulin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041846">
        <property type="entry name" value="ENL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF234">
        <property type="entry name" value="EARLY NODULIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="11">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23264" checksum="9E95940CC28D8E36" modified="2016-04-13" version="1">MATPILQAQTTPITTFCACKPKKMASSTSFALLFLAIATATTTAAAKEFQVGDAVGWRIPATNETELYNVWASRRRFHIGDSLRFHYKTDSVVVVEKWGFYHCDSSNPLSFFNDGNTLINLDKVGTIYFISGNADRCNKGQRMTVKVMNLHQFPPSIAPSIAIPPQNNPYYAMSPSPSPSHLSGSGTSSDSGPVASVSASIMVLIVGLGLWLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHB3</accession>
    <name>A0A124SHB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001074">
        <property type="protein sequence ID" value="KVI09018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SHB3"/>
    <dbReference type="Gramene" id="KVI09018">
        <property type="protein sequence ID" value="KVI09018"/>
        <property type="gene ID" value="Ccrd_012585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071:SF1">
        <property type="entry name" value="CYTOCHROME B_B6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="HEME EXPORTER PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="10">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="25818" checksum="6221C26F83D6065C" modified="2016-04-13" version="1" fragment="single">ISPSTSRKPYALEEACTVWEGVLIDKKEESTSTDMSLGTTIHNIEITLEKGGQLARAAGAVVKLIAKEGKSATLKLPSGEVRLISKNCSATVGQVGNVGVNQKKHILTHISFSIVSIVITIHLITLLGNEIINPYDSSEKGMXATFLCLTGLLITRWIYSGHFPLSDLYESLIFFSWSFSLIHIVPXLKIRKNYLTTITASSTIFTQGFATSGLLTEIHKPTILVPALQSEWLIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHL3</accession>
    <name>A0A124SHL3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHL3"/>
    <dbReference type="STRING" id="59895.A0A124SHL3"/>
    <dbReference type="Gramene" id="KVI09918">
        <property type="protein sequence ID" value="KVI09918"/>
        <property type="gene ID" value="Ccrd_011709"/>
    </dbReference>
    <dbReference type="OMA" id="HAEESIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="52498" checksum="0F939D88671313AE" modified="2016-04-13" version="1">MVPNKQAEEAIVSGEMKGENEQDQGEGEAGVDQSMSGFKNFLWHGGSVYDAWFSCASNQVAQVLLTLPYSFSQLGMLSGIILQVFYGLLGSWTAYLISVLYVEYRARKEKENVSFKNHVIQWFEVLDGLLGPHWKAVGLAFNCTFLLFGSVIQLIACASNIYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIAALIHGQMVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKYIYLFATLYVFTLTLPSSAAMYWAFGDQLLNHSNAFSLLPKTRFRDAAVILMLIHQFITFGFACTPLYFVWEKVVGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPALAHMLTYRKASARQNAAEKPPFFLPSWTAMYIVNVFIVVWVFVVGFGFGGWASMTNFIKQVDTFGLFAKCYQCKPPPPLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103T1T5</accession>
    <name>A0A103T1T5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007251">
        <property type="protein sequence ID" value="KVH02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103T1T5"/>
    <dbReference type="Gramene" id="KVH02539">
        <property type="protein sequence ID" value="KVH02539"/>
        <property type="gene ID" value="Ccrd_026007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="16025" checksum="C412C5972003635D" modified="2016-04-13" version="1">MKHHRQHIRNKGLHLMQLAAMFSRFNERLEEALWLEGSADWYEACVPFFLLVDMTTHMLVIDTGTAPIFIGWWIIWHLKVWQKLRFLVFRLLQCTWYLVRALSTHNAEKDAEKCKIIDGMIAIFRVLVEGGDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XAB6</accession>
    <name>A0A103XAB6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-processing protein, HAT helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_025415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006317">
        <property type="protein sequence ID" value="KVH87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XAB6"/>
    <dbReference type="STRING" id="59895.A0A103XAB6"/>
    <dbReference type="Gramene" id="KVH87043">
        <property type="protein sequence ID" value="KVH87043"/>
        <property type="gene ID" value="Ccrd_025415"/>
    </dbReference>
    <dbReference type="OMA" id="NARFREK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000159">
        <property type="entry name" value="Tetratricopeptide repeat (TPR)-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF26">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="798"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="897" mass="101524" checksum="3198281AAD8B112D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB45</accession>
    <name>A0A103XB45_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aspartic peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006179">
        <property type="protein sequence ID" value="KVH87463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB45"/>
    <dbReference type="STRING" id="59895.A0A103XB45"/>
    <dbReference type="Gramene" id="KVH87463">
        <property type="protein sequence ID" value="KVH87463"/>
        <property type="gene ID" value="Ccrd_025294"/>
    </dbReference>
    <dbReference type="OMA" id="FMEATIE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF76">
        <property type="entry name" value="ASPARTIC PROTEINASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="80"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50395" checksum="070873A7AF9A0FC2" modified="2016-04-13" version="1">MGRTKTSIAIFLICSAFLYPILLISASTNYVRIKLKFNNTNRVVSRSELSQSLRARRQNNQDGSPGSDIIMLKNYMDAQYYGEIGIGTPPQTFNVIFDTGSSNLWVPSSKCFFSMSCYVHPKYKSIKSSTYKENGKYAAIMYGSGLVYGFFSNDDVKVGDLVIKDQEFIEAISEPGMSFIDGKFDGILGLGFKEISVGKVAPVWDTMVRQGLVKDPMFSIWLNPGAKQEKGGEIVFGGVDSDHYKGYCQHGCSAIADSGTSMLAGPTSVVTEINKAIGVKTVANQESQFVVKEHGENILDLLSEKVQPKKICSKIGLCASNGTNSHSDDVSSGNGDGFCAACETMVMWMENQRKQNKTRERILSDGNKLTDAFLDANVDCENIASMPDISFMIGGKDFVLSPHEYIVKDTDDDASCVSGFTPMDIPSPNGLLWILGDVFMGRYHTIFDYGNLRLGFAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBI6</accession>
    <name>A0A103XBI6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005934">
        <property type="protein sequence ID" value="KVH87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBI6"/>
    <dbReference type="STRING" id="59895.A0A103XBI6"/>
    <dbReference type="Gramene" id="KVH87678">
        <property type="protein sequence ID" value="KVH87678"/>
        <property type="gene ID" value="Ccrd_025028"/>
    </dbReference>
    <dbReference type="OMA" id="IWKPESI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34116:SF9">
        <property type="entry name" value="OS08G0346600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34116">
        <property type="entry name" value="PLASMINOGEN ACTIVATOR INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="22722" checksum="2E6EFE3FDB2F8EEE" modified="2016-04-13" version="1">MEPGFLITLFFLISESVKKQNPSQIGAVLRVLFMSLPTLILQTVVVFFNPLKAQLPWMMIRSSFLSVDESGNKSMRCTYPLLSSIVFGAFGVVYSVGLLICCWRVVSLVINKKMKLRIEVLGWTVMMSVLVESLLLGVVGIWKPESIWYGGVLLGMFVSVAICGGVAEIVLVIKPIVEALVAAGDYCQWNPVVRYMQPVEDRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC19</accession>
    <name>A0A103XC19_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Brevis radix-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005669">
        <property type="protein sequence ID" value="KVH87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC19"/>
    <dbReference type="STRING" id="59895.A0A103XC19"/>
    <dbReference type="Gramene" id="KVH87960">
        <property type="protein sequence ID" value="KVH87960"/>
        <property type="gene ID" value="Ccrd_024659"/>
    </dbReference>
    <dbReference type="OMA" id="GHNMTVA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000028">
        <property type="entry name" value="PH, RCC1 and FYVE domains-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013591">
        <property type="entry name" value="Brevis_radix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF352">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION (RCC1) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08381">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51514">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="212"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="489"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="BRX" evidence="10">
        <location>
            <begin position="830"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="906" mass="99396" checksum="7B9A8EC1DF927FA8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC55</accession>
    <name>A0A103XC55_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005648">
        <property type="protein sequence ID" value="KVH87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XC55"/>
    <dbReference type="STRING" id="59895.A0A103XC55"/>
    <dbReference type="Gramene" id="KVH87989">
        <property type="protein sequence ID" value="KVH87989"/>
        <property type="gene ID" value="Ccrd_024628"/>
    </dbReference>
    <dbReference type="OMA" id="SKRATFW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009920">
        <property type="term" value="P:cell plate formation involved in plant-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000302">
        <property type="entry name" value="Rho GTPase-activating protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000052">
        <property type="entry name" value="Rho GTPase-activating protein REN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052799">
        <property type="entry name" value="Rho_GAP_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="172"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="758"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="580"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="664"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="866" mass="96662" checksum="79600637588787C6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCI9</accession>
    <name>A0A103XCI9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005516">
        <property type="protein sequence ID" value="KVH88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCI9"/>
    <dbReference type="STRING" id="59895.A0A103XCI9"/>
    <dbReference type="Gramene" id="KVH88215">
        <property type="protein sequence ID" value="KVH88215"/>
        <property type="gene ID" value="Ccrd_024395"/>
    </dbReference>
    <dbReference type="OMA" id="WTMERHE"/>
    <dbReference type="OrthoDB" id="1843873at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33492:SF11">
        <property type="entry name" value="OS04G0670900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33492">
        <property type="entry name" value="OSJNBA0043A12.37 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="36147" checksum="29BF52A8FBDBD5FC" modified="2016-04-13" version="1">MSEPPNTSTITPPNIVNVTPYPAISYKNHHLPAIIHGGATTSTVTLSPASNHLREYRKGNWTLEETLVLITAKKLDDERRINATTSATLNIRGGELRWKWVENYCWSHGCLRSQNQCNDKWDNLLRDYKKVREYEVRSPAQDRPSYWSMDKTQRKERNLPSNLLLNIYEALNDVVHRKIPHRQQQPLPPALPPPPPPPPPAAVTTHPPPPASEASAESSETEGEETEKVDSETKRRRVRDIGSSIVDSTTLLSQTLKSYEEKKEKRHRELMELEEQRLRLEETRNEMNRQGIVGLVASINKLSDAIHSLISEKRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCV0</accession>
    <name>A0A103XCV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005458">
        <property type="protein sequence ID" value="KVH88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCV0"/>
    <dbReference type="STRING" id="59895.A0A103XCV0"/>
    <dbReference type="Gramene" id="KVH88293">
        <property type="protein sequence ID" value="KVH88293"/>
        <property type="gene ID" value="Ccrd_024193"/>
    </dbReference>
    <dbReference type="OMA" id="QPIKFAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF13">
        <property type="entry name" value="OS02G0672400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33942" checksum="8440E4CCF986848A" modified="2016-04-13" version="1">MAEFEVAEETTDKKIRKDDSPGEMKPWEQHSAVISIPRYDYKAPTSMLHRSFAGFLVTCPIKREKSATKEAMSILYKYVGSINTCSSEGEEDPQNVVPKRRKVVVSEAKEECTKHTENKILDETTGAKEVSEGSCLSSSKSDANIERSDPLSLVKLTKSGLLLLTFSCGHCPDVVDIVSNIMQSLESGSLKAPLWCHRILPIQTTCVLHEKELCTLTESKGANGNSNPVAMLDRSKCFEVVAAAVKSIVSDSVVDLKCPELSVLIELLPISQLPKGSSHVVAVSVLPRNLIMTKPRLCIKALVPDTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD17</accession>
    <name>A0A103XD17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005399">
        <property type="protein sequence ID" value="KVH88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD17"/>
    <dbReference type="STRING" id="59895.A0A103XD17"/>
    <dbReference type="Gramene" id="KVH88475">
        <property type="protein sequence ID" value="KVH88475"/>
        <property type="gene ID" value="Ccrd_026744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045281">
        <property type="entry name" value="CONSTANS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319:SF114">
        <property type="entry name" value="OS12G0262400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCT" evidence="5">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="214" mass="24312" checksum="DC8169AE3B6A42D5" modified="2016-04-13" version="1">MYGHNHNSFRPHFSDLPPSYRPANYSTSPPPFALDSTTSDGRCYDSPGYTGSQSDCIDTPINNNGLLFQIVSSPAELFDSDGSSSSVTKGFCAGDLEGANMTQHRRRSESPFSNENDIIIKSMNKACRYSPKEKQERIERYRSKKTQRNFDKKIKYVCRKTLADNRPRIKGRFARNDEIERTNNQGGGEEGFDEENVENWMFNFSDPFSSNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDB8</accession>
    <name>A0A103XDB8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Longin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_026207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005355">
        <property type="protein sequence ID" value="KVH88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDB8"/>
    <dbReference type="STRING" id="59895.A0A103XDB8"/>
    <dbReference type="Gramene" id="KVH88652">
        <property type="protein sequence ID" value="KVH88652"/>
        <property type="gene ID" value="Ccrd_026207"/>
    </dbReference>
    <dbReference type="OMA" id="FAYCVYG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF7">
        <property type="entry name" value="LONGIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="49"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="29281" checksum="FE2C6EBF7D629687" modified="2016-04-13" version="1" fragment="single">TEYWKQSCHLKFDPNPFFVHKAKTQGFVHLFDHSVDKGRGKRMKITALLVLKCDSRSDGSDPVILANATDVNHFGYFQRVTVRQFIVFVGRTVAKRTPPDQRHSVQHEEYKVHSYNRNGLCVVGFMDDHYPVRSAFSVLNKVIDEYQKCFGETWRNIQADSTQPWPYLNEALTKFQDPGEADNLLKIQRELDETKIILHKTIDSVLERGEKLDSLVEKSSDLSAASQVDVLTIENLHDMFYKQAKKTNQCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE40</accession>
    <name>A0A103XE40_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_024226</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01005323">
        <property type="protein sequence ID" value="KVH88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE40"/>
    <dbReference type="Gramene" id="KVH88986">
        <property type="protein sequence ID" value="KVH88986"/>
        <property type="gene ID" value="Ccrd_024226"/>
    </dbReference>
    <dbReference type="OMA" id="ATAVTMW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025298">
        <property type="entry name" value="DUF4094"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF375">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13334">
        <property type="entry name" value="DUF4094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4094" evidence="14">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="48951" checksum="3142976DA9F23C49" modified="2016-04-13" version="1">MKERTTMKSRGDQQASRSVISQKWTLLLCIGSFCAGLLFTNRMWTMSDSKLITRPTAIESEGLKLVSEGCDLRKLQMKNVKRDSKQIFGEVSKTHQAIQTLDKTISSLEMELAAARSIQESIVNGSPISEEDTRSAPERRKYLMVVGVNTAFSSRKRRDSRKKLEEEKGIIMRFVIGHSATVGGILDRAIEAEDRKHGDFLRLDHVEGYLELSAKTKTYFATAVTMWDAEFYIKVDDDVHVNIATLGHTLVRHRKKKRVYIGCMKSGPVLAQKGVRYHEPEYWKFGESGNKYFRHATGQLYAISKDLATYISLNQLSFACSIVIKTLSIYLSYWFLMFVLKNRLRHVLHKYANEDVSLGSWFIGLDVEHIDDRRLCCGTPPDCEWKAQAGNICVASFDWTCSGICRSVDRIKEVHRRCGEGENAVWSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEH8</accession>
    <name>A0A103XEH8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005286">
        <property type="protein sequence ID" value="KVH89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEH8"/>
    <dbReference type="STRING" id="59895.A0A103XEH8"/>
    <dbReference type="Gramene" id="KVH89243">
        <property type="protein sequence ID" value="KVH89243"/>
        <property type="gene ID" value="Ccrd_008771"/>
    </dbReference>
    <dbReference type="OMA" id="MAVYRIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF21">
        <property type="entry name" value="AQUAPORIN TIP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="26811" checksum="60015A5AF8B469D9" modified="2016-04-13" version="1">MVSMILFNFCFDSLRLGKLTYDAPNTPSGLVSAALAHAFALFVAVSISANISGGHVNPAVTFASFIGGNISFLCAIVYWIAQLLGSVVACLLLRRNGKNKTSSNLGSKRFMVVILEKLQLIPIKYGTKLQETPAFGLSSDVTVGNALVLEIVMTFGLVYTVYATAVDPKKGNIGIIAPIAIGFIVGANILVGGAYDGASMNPAVCFGPAVVSGTWKHHWIYWVGPFLGAAIAALIYDSIFISDDHESLPVTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEK7</accession>
    <name>A0A103XEK7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005266">
        <property type="protein sequence ID" value="KVH89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEK7"/>
    <dbReference type="STRING" id="59895.A0A103XEK7"/>
    <dbReference type="Gramene" id="KVH89288">
        <property type="protein sequence ID" value="KVH89288"/>
        <property type="gene ID" value="Ccrd_008724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900457">
        <property type="term" value="P:regulation of brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="8">
        <location>
            <begin position="235"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="593" mass="65539" checksum="28BC1EB6CC06C73A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFR1</accession>
    <name>A0A103XFR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005137">
        <property type="protein sequence ID" value="KVH89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFR1"/>
    <dbReference type="Gramene" id="KVH89822">
        <property type="protein sequence ID" value="KVH89822"/>
        <property type="gene ID" value="Ccrd_008180"/>
    </dbReference>
    <dbReference type="OMA" id="NAHLTCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="37805" checksum="DF02E5F37AD45FFD" modified="2016-04-13" version="1">MALGDGGGGGVVAVAGGQAWKAHAAMALVQLLYGGYHVITKVALNDGVNEIVFCVYRDIVALSILAPIAYFREKTTRPAMTRRLLMYFFFLGLTGIFGNQLLFLVGLGYTNPTYAAAVQPSIPVFTFILAAMMGIETVNVLKTEGLAKVGGTLVCVSGAILIVLFRGPALLGYADNLPVASGQREPAGWMFSSFVGFGIDNWHLGVLCLIGNCMCMAAYLAIQAPMLATYSANLSVTAYSYFFGTLFMVATAVSVSNESTNWNLTQSEVLAVLYSHFRRIFDHNGVIYRDLGDVSGKRTSSFRRWPFSDVGATDRSGWVRAFTMSNSDHGLTEMWNLNCSFNTLCKITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHE4</accession>
    <name>A0A103XHE4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHE4"/>
    <dbReference type="STRING" id="59895.A0A103XHE4"/>
    <dbReference type="Gramene" id="KVH90683">
        <property type="protein sequence ID" value="KVH90683"/>
        <property type="gene ID" value="Ccrd_007348"/>
    </dbReference>
    <dbReference type="OMA" id="MNIANEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF19">
        <property type="entry name" value="BET V I_MAJOR LATEX PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="3">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="155" mass="16986" checksum="60E7CFED759AF0FD" modified="2016-04-13" version="1">MFGTLSEETEVKVPASKAWALYGTLELGKAVTGKFVEAIEVVEGDGGAGTILRFALKPGSRFSRYSEKFTKVDDENKVKEVEVVEGGFLDLGFTFYRSRIEIKENPNDDTGSSCLVKFTIEYDVKEEVAADASLVTNKPLIGIMNIANEYLLKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHT4</accession>
    <name>A0A103XHT4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHT4"/>
    <dbReference type="STRING" id="59895.A0A103XHT4"/>
    <dbReference type="Gramene" id="KVH90929">
        <property type="protein sequence ID" value="KVH90929"/>
        <property type="gene ID" value="Ccrd_007052"/>
    </dbReference>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="503" mass="54086" checksum="B8567D624DFA8D1C" modified="2016-04-13" version="1">MTIESFPGSSGYIDSGVDKKITYFSNTYVLGLTVIAGIGGLLFGYDTGVISGALLYIRDEFEEVDKSSFLQETIVSMALVGAMIGAGGGGWINDTYGRKRATLLADVVFALGSFVMAAAPDPYVLIFGRLLVGLGVGVASVTAPMYIAEAAPSEIRGGLVSTNVLMITGGQFLSYLVNLAFTEMGRSISIEPSDVTNACGLPRNGAFSDLVPQMHAEQVPGTWRWMLGVAAVPAIVQFVLMLLMPESPRWLYMKKSKSEAIVVLSKIYDPYRLEEELDQLSSTLEEENQRKNAFTGINTVMYYSPTIVQMAGFSSNQLALLLSLVVALMNAAGTVVGIYLIDHFGRRKLALSSLFGVFLSLILLSAAFFLQSSGSTNVGWIAVLGLALYIAFFAPGMGPVPWTVNSEIYPQSYRGICGGMSATVNWISNLIVAQSFLSVADAVGTEWTFLILAAITVAAISFVFVFVPETKGLTFEEVEKIWKEKAWGSSHGTESLLENGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHY7</accession>
    <name>A0A103XHY7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005084">
        <property type="protein sequence ID" value="KVH91037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHY7"/>
    <dbReference type="STRING" id="59895.A0A103XHY7"/>
    <dbReference type="Gramene" id="KVH91037">
        <property type="protein sequence ID" value="KVH91037"/>
        <property type="gene ID" value="Ccrd_006982"/>
    </dbReference>
    <dbReference type="OMA" id="HYNEVQD"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044229">
        <property type="entry name" value="NOA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47569">
        <property type="entry name" value="NO-ASSOCIATED PROTEIN 1, CHLOROPLASTIC/MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47569:SF2">
        <property type="entry name" value="NO-ASSOCIATED PROTEIN 1, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="1">
        <location>
            <begin position="175"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="559" mass="61748" checksum="CCA4F6E981B804C0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIA3</accession>
    <name>A0A103XIA3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005052">
        <property type="protein sequence ID" value="KVH91306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIA3"/>
    <dbReference type="Gramene" id="KVH91306">
        <property type="protein sequence ID" value="KVH91306"/>
        <property type="gene ID" value="Ccrd_006674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20828" checksum="CA594DD7514015D6" modified="2016-04-13" version="1">MKKIPKQAVSFIVSNPFKGFAPASLLFPMTNFSFSELSSRIHLSQTILPQFYSNSALNHKPQFDRPRSMFEKITKLDNALELFDEMTQRQPLPSVVKFTQLLQTVTRMKHYSCSIDLFKQMVAISVPVDEYTLAIVIKCYCQLFHTSEGFAVVAYGLKRGVLPDVWIFTILLDGLILEDRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIA6</accession>
    <name>A0A103XIA6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_006735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005066">
        <property type="protein sequence ID" value="KVH91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIA6"/>
    <dbReference type="STRING" id="59895.A0A103XIA6"/>
    <dbReference type="Gramene" id="KVH91249">
        <property type="protein sequence ID" value="KVH91249"/>
        <property type="gene ID" value="Ccrd_006735"/>
    </dbReference>
    <dbReference type="OMA" id="KRMMGPP"/>
    <dbReference type="OrthoDB" id="1875064at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000020">
        <property type="entry name" value="serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000028">
        <property type="entry name" value="serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase D6PK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="293"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="691" mass="76297" checksum="638ADED80A667259" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIT5</accession>
    <name>A0A103XIT5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trigger factor, ribosome-binding, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004949">
        <property type="protein sequence ID" value="KVH91474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIT5"/>
    <dbReference type="STRING" id="59895.A0A103XIT5"/>
    <dbReference type="Gramene" id="KVH91474">
        <property type="protein sequence ID" value="KVH91474"/>
        <property type="gene ID" value="Ccrd_006503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560:SF4">
        <property type="entry name" value="OS01G0894700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="22987" checksum="F849F7972CFCACAD" modified="2016-04-13" version="1">MMTSMKITMNIPPTFFQFKHCNNLNPTAKSNHVHVPIWHTLATINPFCTKRSLDGRPLDSHNSHKSIVSFVRPLPAVEPGVEASISDENLVTVKNANILVELQDDDKMQVKVELSGKETQIVFDKVLTNLARTAPPVPGFRRQKGDRVTKFVIQEINNICVKDNKINTIQSAEELESSFNPGSDFGFNATIELEKPDTESLESSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJJ7</accession>
    <name>A0A103XJJ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJJ7"/>
    <dbReference type="STRING" id="59895.A0A103XJJ7"/>
    <dbReference type="Gramene" id="KVH91879">
        <property type="protein sequence ID" value="KVH91879"/>
        <property type="gene ID" value="Ccrd_006097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF15">
        <property type="entry name" value="BIFUNCTIONAL UDP-GLUCOSE 4-EPIMERASE AND UDP-XYLOSE 4-EPIMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="38529" checksum="11C67D2098AFC3BB" modified="2016-04-13" version="1" fragment="single">WLTNPLVHFLRVVNICALIQEDVSIPLLFHHFSDKIHANSRSLRVIPVPEFFSMNDCSSISVMDSSILVTGGAGFIGTHTVVQLLNQGFKVTIIDNLDNSVEEAVLQVRDLVGPALSLNLQFHLGDIRNKDDLEKLFSLNKFDAVIHFAGLKAVGESVIYPFRYFDNNLIGSITLYQVMEKYNCKKLFLEEIARDIHMADSEWKIILLRYFNPVGAHESGKLGEDPKGIPNNLMPYIQQVAVGRLPELNVRDYIHVMDLADGHVAALKKLFTKQEIGCFACNLGTGRGTSVLEMVAAFEKASGKVLTYGQIKIHTAKYGIEEMCRDQWKWASQNPWGYCSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKY2</accession>
    <name>A0A103XKY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004811">
        <property type="protein sequence ID" value="KVH92658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKY2"/>
    <dbReference type="Gramene" id="KVH92658">
        <property type="protein sequence ID" value="KVH92658"/>
        <property type="gene ID" value="Ccrd_005318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16035" checksum="49A2EEF467ACA216" modified="2016-04-13" version="1">MATLHHRLKTQAMMQPLSLLRQNLLIIITALKPISLLKSLLLNLLIKSTRIQIMIAQQTITTGQMDRTVAISSQIGLQPRSMLLLVAVLPLVTSLAMRRNDGLAFVHVRYDPYSIACPQLVKDAIESELQFICCQNHVPFHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMA8</accession>
    <name>A0A103XMA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C (PP2C)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004766">
        <property type="protein sequence ID" value="KVH93456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMA8"/>
    <dbReference type="STRING" id="59895.A0A103XMA8"/>
    <dbReference type="Gramene" id="KVH93456">
        <property type="protein sequence ID" value="KVH93456"/>
        <property type="gene ID" value="Ccrd_004503"/>
    </dbReference>
    <dbReference type="OMA" id="MEVSSTK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="900"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130836" checksum="6EEE93F6A8667BF0" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMT6</accession>
    <name>A0A103XMT6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004629">
        <property type="protein sequence ID" value="KVH93693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMT6"/>
    <dbReference type="Gramene" id="KVH93693">
        <property type="protein sequence ID" value="KVH93693"/>
        <property type="gene ID" value="Ccrd_004255"/>
    </dbReference>
    <dbReference type="OMA" id="VPFIACC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF154">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="654" mass="74773" checksum="3FE2CD4D53D64DAD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPE0</accession>
    <name>A0A103XPE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004554">
        <property type="protein sequence ID" value="KVH94400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPE0"/>
    <dbReference type="STRING" id="59895.A0A103XPE0"/>
    <dbReference type="Gramene" id="KVH94400">
        <property type="protein sequence ID" value="KVH94400"/>
        <property type="gene ID" value="Ccrd_003533"/>
    </dbReference>
    <dbReference type="OMA" id="VDCDNNY"/>
    <dbReference type="OrthoDB" id="1904546at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05489">
        <property type="entry name" value="xylanase_inhibitor_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000041">
        <property type="entry name" value="Basic 7S globulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000045">
        <property type="entry name" value="Basic 7S globulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033868">
        <property type="entry name" value="Xylanase_inhibitor_I-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF22">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118987" evidence="5">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="46227" checksum="624381FDD4F88C25" modified="2016-04-13" version="1">MASSNVQLLVFSVFLFLSLSFAQPSFRPDALVVPVRKDAATGQYVTQINQKTPLVPENLVVDLGGKFLWVDCDNNYISSTYRPARCRSALCSLAGADGCGDCFGSARPGCNNDTCGVSPYNPIIRTATSGELATDLVQIRSTDGSNPGRPVNISRFLFSCAPTFLLQGLANGVSGMAGLGRTRIALPTQLAAAFSFDRKFAICLSSSTTSDGVVFFGDGPYNFLPNIDVSQSLMRTRLIINPVSTTGASSPGEPSAEYFIGVSSIRVNSKSLSLNASLLSIDNQGNGGTKISTVNPYTILETSIYNTLTAAFISEAAIRNITRVPSVAPFDVCFSTSNVLSTRVGPAVPSIELVLENQNVVWMITGSNSMVQVNDNVLCLGIINGGSNPRTSIVIGGYQLENNLLQFDLATSNLGFSSTLLGRQTTCANFNFTSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ47</accession>
    <name>A0A103XQ47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004514">
        <property type="protein sequence ID" value="KVH94862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ47"/>
    <dbReference type="Gramene" id="KVH94862">
        <property type="protein sequence ID" value="KVH94862"/>
        <property type="gene ID" value="Ccrd_003068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15590" checksum="07876FB1EB153D8F" modified="2016-04-13" version="1">MPKRHTLKTVTVFGLLPDNIKNRIDQLGTFGIVTFSPVVSGTRLAKNKVVRSEDLTIGTRSETVHGTGLKIHEHSPWNEPATTCFIVIDIDPLKLEIGIALVTAGGINAVFRTNHLPELGTDLVAALASLDVKNLTHFFLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQC2</accession>
    <name>A0A103XQC2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Josephin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004511">
        <property type="protein sequence ID" value="KVH94880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQC2"/>
    <dbReference type="STRING" id="59895.A0A103XQC2"/>
    <dbReference type="Gramene" id="KVH94880">
        <property type="protein sequence ID" value="KVH94880"/>
        <property type="gene ID" value="Ccrd_003055"/>
    </dbReference>
    <dbReference type="OMA" id="HGRRRIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34355">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34355:SF1">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15884" checksum="B4266B12007898F1" modified="2016-04-13" version="1">MNRRVSFSPDVDGMPSPPPPVHFTKHGGDRTNTTEPMIRILTFRPPKTSSSGGFSAMRFLGRIRAKFAKALGFVSSSSRKVSSSSSSTTSSSSYSCTLERSRSYVEALDSHRAQAIEDCIQFLNSNSSSSSSSSFQRSKSLSSFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR26</accession>
    <name>A0A103XR26_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004392">
        <property type="protein sequence ID" value="KVH95338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR26"/>
    <dbReference type="STRING" id="59895.A0A103XR26"/>
    <dbReference type="Gramene" id="KVH95338">
        <property type="protein sequence ID" value="KVH95338"/>
        <property type="gene ID" value="Ccrd_002573"/>
    </dbReference>
    <dbReference type="OMA" id="RLWFWLP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000030">
        <property type="entry name" value="F-box/kelch-repeat protein At3g61590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF153">
        <property type="entry name" value="F-BOX DOMAIN, GALACTOSE OXIDASE_KELCH, BETA-PROPELLER, F-BOX-LIKE DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="416" mass="47319" checksum="09DE4F7DBD613423" modified="2016-04-13" version="1">MLFWVTDSFSLSVPGASWSDDESDTNRKGSGVFLLNLELIENDNNQEENSVSIDILPDDIHERILSRLPLSAIFKAACVCKKWNQIVHSKKFTLTDANFLSEKTWYFMFTSSAEPVGYLYDSGLRKWYNFELPFLVHHTWKIAPSCGLVSFMDDETCKKIHICNPITREYETLKNPPSPGFPVYSALAFSVDQSNSKYTISIVRAMQASEDFLSWLVSIHIYNSKEKTWLPPVMGGMEGWRPGDVSLICDNILYILVFCTRPNEVQNFHGLITYNLETFNPIGVLKEESVISAPCALTCGRLMKVQRQVVLVGGIGRADRPGVIKGIGIWVLNGKEWKEVTRMPQKFVQGFGELDDVFASSGGGDLIYIQSYGGTAVLIYDMDTRQWFWCQKCQMHKKFPLEIFSGFCFEPRLQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR40</accession>
    <name>A0A103XR40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR40"/>
    <dbReference type="Gramene" id="KVH95315">
        <property type="protein sequence ID" value="KVH95315"/>
        <property type="gene ID" value="Ccrd_002620"/>
    </dbReference>
    <dbReference type="OMA" id="CKSAACD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33148:SF33">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33148">
        <property type="entry name" value="PLASTID MOVEMENT IMPAIRED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="212" mass="23747" checksum="22F284FD21FE3504" modified="2016-04-13" version="1">MGNCSFKGFDPSLDPIRVITCSGQALEFNGPKLVSEVIKDFPKHGIFKKDQLSSPLDHREQLIGGQFYHLFPLFPEEIEKRDQTFEEKALSELGAIEAEPVRMSTSTVALQLVTKNLTDGSGFEVLPPPRKGVWKVKLMINTKQLEEILSEEVNTEALIEQMRVAAASSRKAVPRRNKLKWGVKLKPIFCNVLNKMVVDDNSSPKSVTPILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUJ4</accession>
    <name>A0A103XUJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA-type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003854">
        <property type="protein sequence ID" value="KVH97129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XUJ4"/>
    <dbReference type="Gramene" id="KVH97129">
        <property type="protein sequence ID" value="KVH97129"/>
        <property type="gene ID" value="Ccrd_000773"/>
    </dbReference>
    <dbReference type="OMA" id="STSESSX"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055278">
        <property type="entry name" value="CDC48c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="38381" checksum="6E08315F918C053F" modified="2016-04-13" version="1" fragment="single">MGKAGKSPGTSSVFERVLRRRVHETFGNATPSFDEIVDRLRATFPEYGGHKLQPFTRMVKQALDSSNSKDKNKSRRNDDDDRRSIFNDDDDGTSPSLRSPASKKAKKIDSREQRLQMLEMKHVARRRIKLQSTSESSXSSSSDVEEDRSAVSTSDNEVYSLQFEPEFDLTKSMLRNKYSGSKIDGKVDEKRKNVELEVVTNSNNKVNTKVDLMKEDRRVKPVVKAKAQKQKNLSNDDGVDDNGKDDGPRFKDLGGMDVVLDELKMEVIVPLFHPQLPRSLGVRPMAGILLHGPPGCGKTKLAHAIANETGVPFFKISTTELVSGISDSFNIENLSLLTMVTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUS7</accession>
    <name>A0A103XUS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase A22B, signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_000652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003846">
        <property type="protein sequence ID" value="KVH97249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUS7"/>
    <dbReference type="Gramene" id="KVH97249">
        <property type="protein sequence ID" value="KVH97249"/>
        <property type="gene ID" value="Ccrd_000652"/>
    </dbReference>
    <dbReference type="OMA" id="KDYCVLF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000007">
        <property type="entry name" value="Signal peptide peptidase-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF102">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH97249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="556" mass="61544" checksum="BD1498AA26C89B65" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUX9</accession>
    <name>A0A103XUX9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_000544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003834">
        <property type="protein sequence ID" value="KVH97349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUX9"/>
    <dbReference type="STRING" id="59895.A0A103XUX9"/>
    <dbReference type="Gramene" id="KVH97349">
        <property type="protein sequence ID" value="KVH97349"/>
        <property type="gene ID" value="Ccrd_000544"/>
    </dbReference>
    <dbReference type="OMA" id="DFHDLCE"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901001">
        <property type="term" value="P:negative regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="11">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH97349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="44494" checksum="CBD04228EA601121" modified="2016-04-13" version="1">MPPKAAKSKEAPVERPILGRFSSHLKIGIVGLPNVGKSTLFNTLTKLSIPAENFPFCTIEPNEARVNIPDERFEWLCQLFKPKSEVSAFLEIHDIAGLVKGAHEGQGLGNNFLSHIRAVDGIFHVLRAFEDPDIIHVDDSVDPVRDLEVITAELRLKDIEFMERKIEDLEKSMKRSNDKQLKVELELCVKVKAWLESEKDIRLGDWKAADIEILNTFQLLTAKPVVYLVNMNEKDYQRKKNKFLPKIHAWVQEHGGEPIIPFSCALERNLADLPEDEVAKYCEENKTQSALPKIIKTGFSAINLIYFFTAGPDEVKCWQIRRQTKAPQAAGAIHTDFERGFICAEVMKFEDLKELGSEPAVKAAGKYKQEGKTYVVQDGDIIFFKFNVSGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV30</accession>
    <name>A0A103XV30_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPRING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003834">
        <property type="protein sequence ID" value="KVH97365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV30"/>
    <dbReference type="STRING" id="59895.A0A103XV30"/>
    <dbReference type="Gramene" id="KVH97365">
        <property type="protein sequence ID" value="KVH97365"/>
        <property type="gene ID" value="Ccrd_000528"/>
    </dbReference>
    <dbReference type="OMA" id="DSCDAVC"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481:SF0">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="9">
        <location>
            <begin position="253"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="39273" checksum="7848D3566FE356A9" modified="2016-04-13" version="1" fragment="single">HLSSSLDTCCDHTPRINWTLVLWERLFHSRFQAPRSPKSTVTLDLAFRIWNPVKSLLIKIDLALHSRDLSERKEIRVLDIQMDFKFKYLQLLIFMLASAAFAIRKDVSFQETQICRTTVQGRYLITDYTGYVCDALSLDPQSHCCRVKKEQYSCHGCNLVSQCCNSYEYCVSCCLNPERIHIDQALTVKIAKPVTSGSYSSLFDYCAGRCRHNSESVVHENAYHSEFHHCFALPSNMSAGITDTQIEVRLIGINVIVGKQGESCDSVCKSSGQSCVPSKFVLINQCEIMQKYMKCRGSCLASIGSDQPAEVVEDAPTNLNPGACLYTRRPSLLSCDGSHQHTRRLCPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVQ3</accession>
    <name>A0A103XVQ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Voltage-dependent anion-selective channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003819">
        <property type="protein sequence ID" value="KVH97773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVQ3"/>
    <dbReference type="STRING" id="59895.A0A103XVQ3"/>
    <dbReference type="Gramene" id="KVH97773">
        <property type="protein sequence ID" value="KVH97773"/>
        <property type="gene ID" value="Ccrd_000128"/>
    </dbReference>
    <dbReference type="OMA" id="INAGCHK"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000003">
        <property type="entry name" value="Outer mitochondrial membrane protein porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="29454" checksum="530F22F16DE844B2" modified="2016-04-13" version="1">MGKGPGLYPDIGKKARDLLYKDYQSDHKFSLTTYTVNGVSITSSGAKKGELFLADVNTKLINKNITTDVKVDTNSKVFTTITIDEPAPGLKTIFSFVVPDQRSGKVELQYLHEHAGISTSIGLTASPIVNFSGVAGNNTVALGTDISFDTATGNFTKYNAGLSFSTSDLIASVTLNDKADTLTASYYHTVSLLTNTVVGAELSHGFSSNENSLIIGTQHALDPLTTVKGRVNNFGIASALLQHEWRPKSFFTISGEVDTRAIEKSAKVGLALALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWR9</accession>
    <name>A0A103XWR9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003803">
        <property type="protein sequence ID" value="KVH98284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWR9"/>
    <dbReference type="STRING" id="59895.A0A103XWR9"/>
    <dbReference type="Gramene" id="KVH98284">
        <property type="protein sequence ID" value="KVH98284"/>
        <property type="gene ID" value="Ccrd_023495"/>
    </dbReference>
    <dbReference type="OMA" id="RSKYHCD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058868">
        <property type="entry name" value="ARM_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46578">
        <property type="entry name" value="ARM-REPEAT/TETRATRICOPEPTIDE REPEAT (TPR)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46578:SF1">
        <property type="entry name" value="ARM-REPEAT_TETRATRICOPEPTIDE REPEAT (TPR)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26524">
        <property type="entry name" value="ARM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARM repeat N-terminal plant" evidence="1">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="623" mass="71683" checksum="9A49428861544E71" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWT9</accession>
    <name>A0A103XWT9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XWT9"/>
    <dbReference type="Gramene" id="KVH98358">
        <property type="protein sequence ID" value="KVH98358"/>
        <property type="gene ID" value="Ccrd_023453"/>
    </dbReference>
    <dbReference type="OMA" id="VKIHTTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119179" evidence="7">
        <location>
            <begin position="26"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="135"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="10">
        <location>
            <begin position="461"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="548" mass="58644" checksum="94C8B328FD28E0F3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXC9</accession>
    <name>A0A103XXC9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003788">
        <property type="protein sequence ID" value="KVH98580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXC9"/>
    <dbReference type="Gramene" id="KVH98580">
        <property type="protein sequence ID" value="KVH98580"/>
        <property type="gene ID" value="Ccrd_023194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH98580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="93" mass="11072" checksum="5E1525B4437A1058" modified="2016-04-13" version="1">MVNTLKTKLGLSINFHLDGFTFTKKLKIGLRYKQECFQLEYNNDEEEWVLLMLLSLWAVRELAIVSWWEVPTTSLVHMRQAIFEVKGFFFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYD6</accession>
    <name>A0A103XYD6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003633">
        <property type="protein sequence ID" value="KVH99203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYD6"/>
    <dbReference type="STRING" id="59895.A0A103XYD6"/>
    <dbReference type="Gramene" id="KVH99203">
        <property type="protein sequence ID" value="KVH99203"/>
        <property type="gene ID" value="Ccrd_022577"/>
    </dbReference>
    <dbReference type="OMA" id="YASITSH"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000002">
        <property type="entry name" value="Serine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3130.10:FF:000007">
        <property type="entry name" value="serine acetyltransferase 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="entry name" value="serine acetyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053376">
        <property type="entry name" value="Serine_acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041874">
        <property type="entry name" value="EPS_EpsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42811">
        <property type="entry name" value="SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00971">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine acetyltransferase N-terminal" evidence="7">
        <location>
            <begin position="99"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="40079" checksum="1A110D6421689F6A" modified="2016-04-13" version="1">MQTSVLYHHLHSLSPKFLRSIPHFCPKPHPQTPTINSPKNQLTELAFCVHNPRTQVLENHFKFSIPKKTDQFSFIPISKIHYESISKHKNGEENDDDDVWMMMKDEARSDVDQEPILSDYYFTSILSHHTMESALSNHLSIKLSSSSLPSGTLHDLFMGVLTEDQEIVKAVKADLRAVKERDPACFSYVHCFLHFKGFLACQAHRVAHKLWLQNRKILALLIQNRVSEVLALDIHPGAKIGRGILLDHATGVVVGETAVIGDNVSILHNVTLGGTGKIGGDRHPKIGDGVLIGAGTCVLGNVTIGEGAKIGAGSVVLKDLPARTTAVGNPAKLIGGKENPVKLDKIPSHTMDHTSHIEFYDYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYQ5</accession>
    <name>A0A103XYQ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-phosphate synthase</fullName>
            <ecNumber evidence="4 8">2.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_022404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = sucrose 6(F)-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57723"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; sucrose biosynthesis; sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.14" evidence="4 8"/>
    <dbReference type="EMBL" id="LEKV01003584">
        <property type="protein sequence ID" value="KVH99368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XYQ5"/>
    <dbReference type="Gramene" id="KVH99368">
        <property type="protein sequence ID" value="KVH99368"/>
        <property type="gene ID" value="Ccrd_022404"/>
    </dbReference>
    <dbReference type="OMA" id="YEAHVEY"/>
    <dbReference type="UniPathway" id="UPA00371">
        <property type="reaction ID" value="UER00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046524">
        <property type="term" value="F:sucrose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16419">
        <property type="entry name" value="HAD_SPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006380">
        <property type="entry name" value="SPP-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044161">
        <property type="entry name" value="SPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035659">
        <property type="entry name" value="SPS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012819">
        <property type="entry name" value="SPS_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth_GT-B1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02468">
        <property type="entry name" value="sucrsPsyn_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039">
        <property type="entry name" value="SUCROSE-PHOSPHATE SYNTHASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039:SF1">
        <property type="entry name" value="SUCROSE-PHOSPHATE SYNTHASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="GT-B_Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05116">
        <property type="entry name" value="S6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose synthase first GT-B" evidence="11">
        <location>
            <begin position="137"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="426"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose phosphatase-like" evidence="12">
        <location>
            <begin position="714"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH99368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="955" mass="108360" checksum="C06798BCE93E6B8D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1N1</accession>
    <name>A0A103Y1N1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003187">
        <property type="protein sequence ID" value="KVI00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1N1"/>
    <dbReference type="STRING" id="59895.A0A103Y1N1"/>
    <dbReference type="Gramene" id="KVI00881">
        <property type="protein sequence ID" value="KVI00881"/>
        <property type="gene ID" value="Ccrd_020859"/>
    </dbReference>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000326">
        <property type="entry name" value="ER membrane protein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="4">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="260" mass="29372" checksum="FC7788DC5BA1B02F" modified="2016-04-13" version="1">MVSKTEESQLQQLENQVENRGGGAWEYLSLVRKLKLRRSDKVLKHGLTILNDPKKRSALGPDEWTLYEQVAIAALDCQCLEVAKDCIKVLQKKFPDSKRVGRLEAMLLEAKGSWAEAEKAYSSLLEDNPLDQVISMRRVAMAKARGDILGAIEWLNKYLEIFMADHDAWRELAEIYVSLQMYKQAAFCYEELILSQPMIPLYHLAYADCTSAIAQLTKGRNNEDKEISGLAAAALEKDYKQSSPSKLSLLSSTLRSLKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1N7</accession>
    <name>A0A103Y1N7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003196">
        <property type="protein sequence ID" value="KVI00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1N7"/>
    <dbReference type="STRING" id="59895.A0A103Y1N7"/>
    <dbReference type="Gramene" id="KVI00878">
        <property type="protein sequence ID" value="KVI00878"/>
        <property type="gene ID" value="Ccrd_020867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="8135" checksum="E8E01B64BED7B556" modified="2016-04-13" version="1">MLQAMKLTKDLMGSCIRSLCNSNLAGGFKIGKDTTLPATYIRSAEDPVKDLGGNPPSERPILAFFLREECTEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2K4</accession>
    <name>A0A103Y2K4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003114">
        <property type="protein sequence ID" value="KVI01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2K4"/>
    <dbReference type="Gramene" id="KVI01359">
        <property type="protein sequence ID" value="KVI01359"/>
        <property type="gene ID" value="Ccrd_020370"/>
    </dbReference>
    <dbReference type="OMA" id="NHMENGT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250:SF18">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="22406" checksum="13D4592C676966B9" modified="2016-04-13" version="1">MADHRRWTMDEEDLLITILQDIVINGGKDDNGSFRSGTYETVVSNMQKKIPGISITVKHEQNKIKRLKDKYSVAYDMVNTSGFGWNDANQCVTVEAPKILEEYLKKHPNKKYMANKPFPTYEWLKLVFSKDCATGNMAESATDALESMNMENDDDFSTEVNVPPIPSPSNTTSFPPLKMKEKEQVKREKGQMRYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2P1</accession>
    <name>A0A103Y2P1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4228 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003097">
        <property type="protein sequence ID" value="KVI01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2P1"/>
    <dbReference type="STRING" id="59895.A0A103Y2P1"/>
    <dbReference type="Gramene" id="KVI01433">
        <property type="protein sequence ID" value="KVI01433"/>
        <property type="gene ID" value="Ccrd_020295"/>
    </dbReference>
    <dbReference type="OMA" id="MIRVVHL"/>
    <dbReference type="OrthoDB" id="736928at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20647" checksum="508659D2E3F7AE92" modified="2016-04-13" version="1">MGACCSCRTSTKRTLKTIRVVHLDGVLEVYESPTTVNQVISNLPKHFMSTPVQLIQNVLVPLKLDTQLEPGRIYFVLPFSILRFNEAPGDLINLAKKLTNVAKTHRPRPKPKPAPSTQISLGCSNGEKNNMRNSTKSLSWKPILATIREISFNRRESDLQSFNRRSEIDLQSFRRNESDLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3S9</accession>
    <name>A0A103Y3S9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002671">
        <property type="protein sequence ID" value="KVI01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3S9"/>
    <dbReference type="STRING" id="59895.A0A103Y3S9"/>
    <dbReference type="Gramene" id="KVI01944">
        <property type="protein sequence ID" value="KVI01944"/>
        <property type="gene ID" value="Ccrd_019776"/>
    </dbReference>
    <dbReference type="OMA" id="MSEQINA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="158" mass="17805" checksum="6650F80F3843CEEF" modified="2016-04-13" version="1" fragment="single">MADANKSSAILFKNRSWSPDIHRHIEWEMLKINQRSRFRRSKSLDAVSDVDVTDDDIKELRACFELGFGFDPSNDLDPKLAKAFPALELYADVNRQFNNQNLSRSSSIDSESSSNSDASSNLIVDPNDDPQKVKMRLKLWALVVACSIREASSHSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3T7</accession>
    <name>A0A103Y3T7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythronate-4-phosphate dehydrogenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3T7"/>
    <dbReference type="STRING" id="59895.A0A103Y3T7"/>
    <dbReference type="Gramene" id="KVI01972">
        <property type="protein sequence ID" value="KVI01972"/>
        <property type="gene ID" value="Ccrd_019733"/>
    </dbReference>
    <dbReference type="OMA" id="SYQPSIK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37244">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37244:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36227" checksum="E0D065399361D9F9" modified="2016-04-13" version="1">MGIHSSDKTMDARSMANGLSGNGNGYYGSRHNSYQPGPKVSLSWLDLRVFYIRISKCDINDESTSEYLTLNHVPLNRDTLLEVNGVRSSIHSDGSSTLLRRDRLDKKSEEVTFVSTDSLRTTGSLKFEVFDKDVLLVSGVLDLCHSNGVHGESSDYTGRWRMECETDMVSGNGFLNGKQNMGHEVDPPSLEVCLAGSFAGNPIILTKTLELGYRKKQTRKGLLEAIPENEAMANEEEGSSGLTYKVRASYVSILSVAEYPTYKPEDEYHSHYSGMEYIEGEDGELSWFNAGVRVGVGIGMSVCLGLGIGVGLLVRTYHGTTRNLRRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y493</accession>
    <name>A0A103Y493_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">malate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_019537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y493"/>
    <dbReference type="STRING" id="59895.A0A103Y493"/>
    <dbReference type="Gramene" id="KVI02240">
        <property type="protein sequence ID" value="KVI02240"/>
        <property type="gene ID" value="Ccrd_019537"/>
    </dbReference>
    <dbReference type="OMA" id="TCFINEA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF58">
        <property type="entry name" value="MALATE DEHYDROGENASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="130"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="38"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="283" mass="29245" checksum="4ACDA51393C52D3C" modified="2016-04-13" version="1">MRSATMLRSMLKNSSSSSLLRRTYSSESAPARKVAVLGAAGGIGQPLALLMKLNPLVSSLSLYDIAGTPGVAADVSHINTRSEVVGYMGEENLGKALEGADVVIIPAGALVNMISNPVNSTVPIASEVFKKAGVNVPVVGGHAGITILPLFSQATPTANDLSAEEITALTKRTQDGGTEVVEAKAGKGSATLSMAYAGAIFADACLKGLNGVPDVVECSFVQSNITELPFFASKVLLVRLGKNGVEEVLGLGSLSDYEKQGLEALLPELKSSIEKGIKFANQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4F5</accession>
    <name>A0A103Y4F5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002655">
        <property type="protein sequence ID" value="KVI02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4F5"/>
    <dbReference type="STRING" id="59895.A0A103Y4F5"/>
    <dbReference type="Gramene" id="KVI02337">
        <property type="protein sequence ID" value="KVI02337"/>
        <property type="gene ID" value="Ccrd_019383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001861">
        <property type="entry name" value="PRK00596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="160" mass="17409" checksum="FA3B86CC22A62D9B" modified="2016-04-13" version="1">MAFSSSLAATLFPLCNSSSISSTPKLSGLPFLSNASSTSRVQFQSPRLSTTRVFSAPETLEQPLEIGDSESSTVIVGSDSDKIMDAARTTNAKTMGPVPLPTKKRIYCVLKSPHVHKDARFHFEIRTHQRLIDILHPTAQTIDSLMQLDLPAGVDVEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5E9</accession>
    <name>A0A103Y5E9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5E9"/>
    <dbReference type="STRING" id="59895.A0A103Y5E9"/>
    <dbReference type="Gramene" id="KVI02861">
        <property type="protein sequence ID" value="KVI02861"/>
        <property type="gene ID" value="Ccrd_018874"/>
    </dbReference>
    <dbReference type="OMA" id="WAMMELD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34936">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34936:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="19123" checksum="B38FC6C540E34B34" modified="2016-04-13" version="1">MITRSKLVEQLRDSQIRSQHKWSPLVIFSPKPNLSTWAMMELDATVSSLSRSDAWSIKWNLEFSLVELLFIGFQITFTKVTVSKTSEGEGDANSAENRRVDVAVAILWATLFIVLVTSSYMTLYFRHFWLSFAIICLGILIPIRLRISRQTIARKKDRRLLLPLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6H6</accession>
    <name>A0A103Y6H6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase, superfamily 1/2, ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_018302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002355">
        <property type="protein sequence ID" value="KVI03399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y6H6"/>
    <dbReference type="Gramene" id="KVI03399">
        <property type="protein sequence ID" value="KVI03399"/>
        <property type="gene ID" value="Ccrd_018302"/>
    </dbReference>
    <dbReference type="OMA" id="DELWEDQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="172"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI03399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="630" mass="70610" checksum="3E1CD3573151435F" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6P3</accession>
    <name>A0A103Y6P3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002347">
        <property type="protein sequence ID" value="KVI03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6P3"/>
    <dbReference type="STRING" id="59895.A0A103Y6P3"/>
    <dbReference type="Gramene" id="KVI03505">
        <property type="protein sequence ID" value="KVI03505"/>
        <property type="gene ID" value="Ccrd_018187"/>
    </dbReference>
    <dbReference type="OMA" id="IGCNHEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046955">
        <property type="entry name" value="PHR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR PHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499:SF85">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB-RELATED FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="40383" checksum="AAFE87FD516353A2" modified="2016-04-13" version="1">MNTLKIGCNHEMVYNMKSREFGGATQQQPWQVGITILPSEMEAKETHQDHQQQQQEQDHQRQQMITYRQENSSCSKTIMEQIGSPSSALYATEKYLGFSQNGVHLSFNDETDVSSVPQMKFDAYMHPLEKPRDSFSFGSYERPYKMRCNNPSERDQIMELKRKLLDESDTSDWRQSQPSICYDGNQDLGGQFGHSGQTGRPPSGQVSINCANPGTVGTIMPSKTRIRWTQDLHDRFVECVSCLGGAEKATPKAILKLMDSEGLTIFHVKSHLQKYRIAKYLPESAKGTENFVESWEEQAKQLKKMFDQQQKANKSQNSEITSLHDDHHAMNLEDDDILNLEVDSENTLFPSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8A3</accession>
    <name>A0A103Y8A3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin ear-binding coat-associated protein 1 NECAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002197">
        <property type="protein sequence ID" value="KVI04370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8A3"/>
    <dbReference type="STRING" id="59895.A0A103Y8A3"/>
    <dbReference type="Gramene" id="KVI04370">
        <property type="protein sequence ID" value="KVI04370"/>
        <property type="gene ID" value="Ccrd_017316"/>
    </dbReference>
    <dbReference type="OMA" id="LYQVSEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000150">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="100"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="37179" checksum="99F0564CFD42B771" modified="2016-04-13" version="1">MDKEHNQSNSTNTNDNPPTLDDSGDIEPAELVLFQVSECYVYLIPPRKTAASYRVSSDALWTVVIELPIGVEPRLDCLWDDSLKSLATSFVIVIWLLSDRADEWDINKWAWEGTMKVVSKGEECIIRLEDKTSGELYARAFLRDGEPHPVEPVIDSSRYFVLRVEENIGGRLRHAFIGIGFRERPQAYDFQAALHDHMKYLNKKKTAEEMEQQFQHTSSVDYSLKDGETLVLQLKNKGGRSVRSKFFEQGLNNLPDQKEKGKKEVAISIKPPPPPPSPLSPPIGSMGTPPGSPSNFNLDHSLSPQSNEPHSVEKQTAQDLPDDDFGDFQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8M8</accession>
    <name>A0A103Y8M8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone, CBP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002014">
        <property type="protein sequence ID" value="KVI04525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8M8"/>
    <dbReference type="STRING" id="59895.A0A103Y8M8"/>
    <dbReference type="Gramene" id="KVI04525">
        <property type="protein sequence ID" value="KVI04525"/>
        <property type="gene ID" value="Ccrd_017156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="212"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="47427" checksum="468943404302E86D" modified="2016-04-13" version="1" fragment="single">IKKKLNPPYHRLFHTHISTTRALPHCLLPHRLLPPPPSISGLRPSTKIDGKSPFASTDSYTFVATAMMPRWSRTLANIYRVGRQTKSDMASDLFVFPCRRISRIAAVEVPVASDASEKNYTAKSELFIFVLINVHCFPQVNLSKMFRSKPCSLALPPESPLRIEEPNYEGIRQFLLKLMLFYSKQSTSIRAANVIYRRVVSQADKPAIYDVFSLEKTFRTTFCMLVLHMWLCLRRLKAEGKEGVELGQYVYEIYNHDLEMRVSKAGVNLLLSKWMRELEKVFYGNIVAFDTAMLPEAKPDELQKAIWKNVFFSEDGPSKLDPAALPAVLAFTRYVRRECTCLSLTAYTFVGISSKQVKLRYAIEVSGQQLTLQQAVQLQLGSQPSSEQANLLRLPPLELKACNRKTEVVAAVSLDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8S3</accession>
    <name>A0A103Y8S3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5 15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_017071</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast thylakoid lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5 15"/>
    <dbReference type="EMBL" id="LEKV01001965">
        <property type="protein sequence ID" value="KVI04610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8S3"/>
    <dbReference type="Gramene" id="KVI04610">
        <property type="protein sequence ID" value="KVI04610"/>
        <property type="gene ID" value="Ccrd_017071"/>
    </dbReference>
    <dbReference type="OMA" id="QVDYDEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009543">
        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000037">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053111">
        <property type="entry name" value="Chloro_FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47598">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP17-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47598:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP17-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="619"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="18">
        <location>
            <begin position="1077"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="565"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="941"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI04610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129523" checksum="2BFC19BCADB37FAE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9A9</accession>
    <name>A0A103Y9A9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001901">
        <property type="protein sequence ID" value="KVI04894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9A9"/>
    <dbReference type="Gramene" id="KVI04894">
        <property type="protein sequence ID" value="KVI04894"/>
        <property type="gene ID" value="Ccrd_016785"/>
    </dbReference>
    <dbReference type="OMA" id="CKSIWEG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37078">
        <property type="entry name" value="NODULE CYSTEINE-RICH (NCR) SECRETED PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37078:SF6">
        <property type="entry name" value="NODULE CYSTEINE-RICH (NCR) SECRETED PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119510" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10164" checksum="B61A5B8B70B9A6C4" modified="2016-04-13" version="1">MHNLKNLGILFLLFTIFGSSTCIRDFGFRSDIHYSQKYTKVFGTLGVECKCCDGASSDEDCKSIWEGSCSKLQCLPWKQHHPKVTSHSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9R7</accession>
    <name>A0A103Y9R7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSXT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_016531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001887">
        <property type="protein sequence ID" value="KVI05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9R7"/>
    <dbReference type="STRING" id="59895.A0A103Y9R7"/>
    <dbReference type="Gramene" id="KVI05137">
        <property type="protein sequence ID" value="KVI05137"/>
        <property type="gene ID" value="Ccrd_016531"/>
    </dbReference>
    <dbReference type="OMA" id="MIPTFAT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="202" mass="21433" checksum="93CEB91FE9004227" modified="2016-04-13" version="1">MMAAYYPTNSVTTDHIQQYLDENKSLILKIVESQNTGKITECAENQAKLQRNLMYLAAIADSQPQAPATHSQYQLGGMMQPGGHYMQQHQQVQQMSPQALMAARSSMLYSQQQYSSLQQQAAMHSQLGMNSGSGGGSSGLHMLQSDSTSAAGASGVGHLGIGGFPDFARKQDIGLSGSTAEERGGGDGGGETHYLKSADEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9T7</accession>
    <name>A0A103Y9T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001887">
        <property type="protein sequence ID" value="KVI05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9T7"/>
    <dbReference type="STRING" id="59895.A0A103Y9T7"/>
    <dbReference type="Gramene" id="KVI05138">
        <property type="protein sequence ID" value="KVI05138"/>
        <property type="gene ID" value="Ccrd_016530"/>
    </dbReference>
    <dbReference type="OMA" id="MDAANDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="17932" checksum="7B8926D5F13058CF" modified="2016-04-13" version="1">MAKRKQGNKEEAMTTYMDMKSQRMELKSILKDIEYMGPSHMTWKEKKALENRKVVSLGGKNMILGQVGGKRGNRSRRASDSRKPEDRVLLSTAGHFKNGILNVKDLLKPGASSRDRSFSSSHGFGNDSSSHGLGGGSSSRGSGKGGKKKGGKKKQGKKGGRRKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBA0</accession>
    <name>A0A103YBA0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBA0"/>
    <dbReference type="STRING" id="59895.A0A103YBA0"/>
    <dbReference type="Gramene" id="KVI05929">
        <property type="protein sequence ID" value="KVI05929"/>
        <property type="gene ID" value="Ccrd_015733"/>
    </dbReference>
    <dbReference type="OMA" id="HYNTVGH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="89"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI05929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="376" mass="41486" checksum="71BE5C1171CFE2AA" modified="2016-04-13" version="1">MAYGVPAINDTTSNISESDSDDIFEITEDEFNNRNLVIGSPVPAAGEIEKDPIYIDDDLGIYEELDDLVQVESDDDHQICIGRNNQKISWGFCVDQGMRKYMEDRIVTFPSFMSLRCDSFGGCTAPHCRFASEVTPIHYFAVFDGHGGSQVSDHCADSLHEEVKKAWESEDCTNEWNKRWQSALSRAYDSADKACEEETGVGSTALVVLVSACQIVAANCGDSRAILCRGSQIIPLSEDHRPDREDEEQRIAKSGGRVLADLWGVLRVDGVLAMSRAIGDKSLKPSVSSVPELTFTTRSEEDECIIIASDGLWDVVSTECVGNLACELLQHERQSAHFGESPTQYVAECLFKEACSRSSSDNFSVIVVDLKPARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCM8</accession>
    <name>A0A103YCM8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_015008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001775">
        <property type="protein sequence ID" value="KVI06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCM8"/>
    <dbReference type="STRING" id="59895.A0A103YCM8"/>
    <dbReference type="Gramene" id="KVI06639">
        <property type="protein sequence ID" value="KVI06639"/>
        <property type="gene ID" value="Ccrd_015008"/>
    </dbReference>
    <dbReference type="OMA" id="WFCGLRA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="91" mass="10234" checksum="3F7EF705270DF838" modified="2016-04-13" version="1">MRKGWCHRSIEFFSEDPIKGVLKTFDTNGDGKLSRKELKVGLKSLGVRFAGIRAWRALRRADANGDGQIGDEEIDELAKYASKWGLSITTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDS2</accession>
    <name>A0A103YDS2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allinase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alliinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001509">
        <property type="protein sequence ID" value="KVI07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDS2"/>
    <dbReference type="STRING" id="59895.A0A103YDS2"/>
    <dbReference type="Gramene" id="KVI07238">
        <property type="protein sequence ID" value="KVI07238"/>
        <property type="gene ID" value="Ccrd_014415"/>
    </dbReference>
    <dbReference type="OMA" id="QWENNSD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.30">
        <property type="entry name" value="EGF-like, alliinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006948">
        <property type="entry name" value="Alliinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037029">
        <property type="entry name" value="Alliinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006947">
        <property type="entry name" value="EGF_alliinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF20">
        <property type="entry name" value="TRYPTOPHAN AMINOTRANSFERASE-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04864">
        <property type="entry name" value="Alliinase_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04863">
        <property type="entry name" value="EGF_alliinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase EGF-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="7">
        <location>
            <begin position="109"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="7">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase EGF-like" evidence="6">
        <location>
            <begin position="433"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="7">
        <location>
            <begin position="490"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="7">
        <location>
            <begin position="747"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase EGF-like" evidence="6">
        <location>
            <begin position="870"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="7">
        <location>
            <begin position="929"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1271" mass="139908" checksum="3C510D74FCA8479C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFI3</accession>
    <name>A0A103YFI3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase NSD-like PHD zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001229">
        <property type="protein sequence ID" value="KVI08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFI3"/>
    <dbReference type="STRING" id="59895.A0A103YFI3"/>
    <dbReference type="Gramene" id="KVI08152">
        <property type="protein sequence ID" value="KVI08152"/>
        <property type="gene ID" value="Ccrd_013482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235:SF3">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone-lysine N-methyltransferase NSD-like PHD zinc finger" evidence="2">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="363" mass="40739" checksum="5D4E4331ACCEC158" modified="2016-04-13" version="1">MASGLNGGGGEWKHENRYATCGHFYHPKCVAKMLHEEGDAATQELQEEIAAGEPFTCHAHKCHKCKKGEHEKVEALQFAGNARDHLSFISEAVKRDKTLQKSEFFASFLEKKPRKRKALDENTEVTMKPSFIVDDMNDECGDEELTLKQSKSAICAICDDGGDLTCCEGKCLEAFHATIESTESRCESLGLRAEIAEITTGFFDVVLQPVAFFITQSVLQRCFMRKVMLQHRNFKKKIAAGEPFACHAHKCHKCKKGEHEKVEALQFAGDARDAELGTPLRNLKFPDIGHSKKQAVESLISKKEVADSDYTSEKGYFSKSQKTRVGKFSSSIRPVDSSKKRVKMSSGSESMKRQRVTEDRENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFT2</accession>
    <name>A0A103YFT2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001143">
        <property type="protein sequence ID" value="KVI08304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFT2"/>
    <dbReference type="STRING" id="59895.A0A103YFT2"/>
    <dbReference type="Gramene" id="KVI08304">
        <property type="protein sequence ID" value="KVI08304"/>
        <property type="gene ID" value="Ccrd_013325"/>
    </dbReference>
    <dbReference type="OMA" id="CIHTGSI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044800">
        <property type="entry name" value="LEC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140:SF70">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0156000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR ABI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="321" mass="35913" checksum="D0F7B779FB9F9F9A" modified="2016-04-13" version="1">MSLTHLSSNHLPETLWYPYPIMDSSPKFPIDHHPHPPPTAFNFNLNPHYDDNQPQDSNCKQPMFEKPLTPSDVGKLNRLVIPKQHAEKYFPLGGGDSAPAVDQQKGLLLSFEDETGKPWRFRYSYWNSSQSYVLTKGWSRFVKEKRLDAGDVVLFERHRFDCDRLFIGWRRRPAAMPMLDSVPVAQPTGGGGGGGGGAGWTTSGFYNAHYNYPSHHLPLSLPHPYKPDCLHAGAGGINDNVEKKQRDMVAASGNPRRVRLFGVNLECPDECEPSTPDGSSHQGGGGAGGQPHYQYHNNLNLNQNQDMNINFSQMRNQQHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ84</accession>
    <name>A0A103YJ84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the A9/FIL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ84"/>
    <dbReference type="STRING" id="59895.A0A103YJ84"/>
    <dbReference type="Gramene" id="KVI10145">
        <property type="protein sequence ID" value="KVI10145"/>
        <property type="gene ID" value="Ccrd_011479"/>
    </dbReference>
    <dbReference type="OMA" id="ECACSTM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35501">
        <property type="entry name" value="PROTEIN YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35501:SF3">
        <property type="entry name" value="PROTEIN YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119776" evidence="4">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="9573" checksum="52AD533C3664CE54" modified="2016-04-13" version="1">MATMDVFQMNQIVTLVLLVVGLVGGSHGQTCPNQLENLNVCAPFVVPGSTNLIPSSDCCVALEAVDHACLCNTIRVASSLPTQCNLPLSCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJM5</accession>
    <name>A0A103YJM5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001021">
        <property type="protein sequence ID" value="KVI10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJM5"/>
    <dbReference type="STRING" id="59895.A0A103YJM5"/>
    <dbReference type="Gramene" id="KVI10370">
        <property type="protein sequence ID" value="KVI10370"/>
        <property type="gene ID" value="Ccrd_011253"/>
    </dbReference>
    <dbReference type="OMA" id="FIQYQAH"/>
    <dbReference type="OrthoDB" id="659599at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33625">
        <property type="entry name" value="OS08G0179900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33625:SF4">
        <property type="entry name" value="OS08G0179900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="30523" checksum="22F2D0977FB1C23B" modified="2016-04-13" version="1">MGGGAAMRAAAKVAGLGVSNGGLRGGGNHVVSAARRSVASGVSSSDDVKLAIANKTTNSSVEKGYDDWEFADELLNDPMPRLVFGGAPTIQEAKQATSDLGDALDKTYLSSNDQNSSLLFDLEHVETKPCLVTDTCASKHAIQAFRLLHENTEAQNVVASIASDPNVWTAVLKNEALVDFLQTHKTSVIFPQVNDERSPEASESKSASGKGFRDYVEDIKQKISVTVVDMMTSFSDTFLSLFAGGSAKGQEYTMNPDGTAGISVEKTTIAATLMGLAIMVITVVVLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJS9</accession>
    <name>A0A103YJS9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with F-actin.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJS9"/>
    <dbReference type="STRING" id="59895.A0A103YJS9"/>
    <dbReference type="Gramene" id="KVI10431">
        <property type="protein sequence ID" value="KVI10431"/>
        <property type="gene ID" value="Ccrd_011189"/>
    </dbReference>
    <dbReference type="OMA" id="TVNHLYV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21299">
        <property type="entry name" value="CH_AtFIM_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000034">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF62">
        <property type="entry name" value="FIMBRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="65"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="256"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="377"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="577" mass="64865" checksum="37F3DB1BD99A9AE4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK84</accession>
    <name>A0A103YK84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BURP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001003">
        <property type="protein sequence ID" value="KVI10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK84"/>
    <dbReference type="STRING" id="59895.A0A103YK84"/>
    <dbReference type="Gramene" id="KVI10685">
        <property type="protein sequence ID" value="KVI10685"/>
        <property type="gene ID" value="Ccrd_010866"/>
    </dbReference>
    <dbReference type="OMA" id="DNIVWVT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF67">
        <property type="entry name" value="BURP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BURP" evidence="1">
        <location>
            <begin position="48"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="30179" checksum="2BB28F8093445AD5" modified="2016-04-13" version="1">MHTHTKLKFCSCREIIDKNPKNDRNEENRIKVYGTNEVDDLDPALRVFFDVNDLYKGKNMWIYFAINDPSTTPRLLAREQADSIPFSSSNLPYLLEFLSLAGDSPQAKAMEMTLKQCELEPTAGEVRFCATSLESMLDSTRRILGEIKLKALTTKIHDLLGSNHTALQRYTFLKEPLELHVHDMVACHTMAYPYAVYYCHGQKGSNRAFEISLGGENGDRVDAIAVCHMNTSMWDPDHVAFRVLGGHPGSSPVCHFLPADNIAWIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKD4</accession>
    <name>A0A103YKD4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase/vanadium-dependent haloperoxidase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001004">
        <property type="protein sequence ID" value="KVI10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKD4"/>
    <dbReference type="STRING" id="59895.A0A103YKD4"/>
    <dbReference type="Gramene" id="KVI10677">
        <property type="protein sequence ID" value="KVI10677"/>
        <property type="gene ID" value="Ccrd_010919"/>
    </dbReference>
    <dbReference type="OMA" id="CILECRF"/>
    <dbReference type="OrthoDB" id="1716650at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="ACID PHOSPHATASE/VANADIUM-DEPENDENT HALOPEROXIDASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446:SF31">
        <property type="entry name" value="ACID PHOSPHATASE_VANADIUM-DEPENDENT HALOPEROXIDASE-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="18469" checksum="22D58F89E3101A50" modified="2016-04-13" version="1">MDEVITIADAAYRASKVTGTAAMPSSSVPVLPYSVPLLSAFLAFAIAQFLKVITTWYKEKRWDPKKIMGSGGMPSSHSSTVVALAVSIGLHEGVEASTFAIAVVLAFIVMYDASGVRLHAGRQAEVLNQIVCEFPPEHPLSTSRPLRDSLGHTPLQVVAGAMLGCIVAFGIKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKF8</accession>
    <name>A0A103YKF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001007">
        <property type="protein sequence ID" value="KVI10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKF8"/>
    <dbReference type="Gramene" id="KVI10642">
        <property type="protein sequence ID" value="KVI10642"/>
        <property type="gene ID" value="Ccrd_010965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16118" checksum="CB5FE40ED4E27F0B" modified="2016-04-13" version="1">MDVVDTTEVVVVEDTTEVVVVEDTTEVVVVEDTTVVVDGEDTTVVVVVDVEDTTVVVVDVEEVEEDTVVAGMVVVVDVTMEGASVAARSQRQLHTSKLRIDAAIGDEPSFPSRVKKMIHHAILQYVLLIHVIIDMASIERSVYLICVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL44</accession>
    <name>A0A103YL44_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maturase K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000889">
        <property type="protein sequence ID" value="KVI11141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL44"/>
    <dbReference type="STRING" id="59895.A0A103YL44"/>
    <dbReference type="Gramene" id="KVI11141">
        <property type="protein sequence ID" value="KVI11141"/>
        <property type="gene ID" value="Ccrd_010455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002866">
        <property type="entry name" value="Maturase_MatK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34811">
        <property type="entry name" value="MATURASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34811:SF1">
        <property type="entry name" value="MATURASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19806" checksum="EB88381869061F03" modified="2016-04-13" version="1">MSVIIGIVLLLQIQRKPVLLFQNEIADYSFFYVLLMYVNMNLASSFSVTNLLTYNQHLLEPFLNEYISMEKWSILQKSLSGLFKLIYGCSMILSCIMLGRIYINQLSNHSLDFMGYRSSVRLKRSMVRNQMLENAFLIDNAIKKFDTIVPIMPLIGSLAKSKFCNALGAFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMA8</accession>
    <name>A0A103YMA8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid-binding, OB-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000066">
        <property type="protein sequence ID" value="KVI11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMA8"/>
    <dbReference type="Gramene" id="KVI11635">
        <property type="protein sequence ID" value="KVI11635"/>
        <property type="gene ID" value="Ccrd_009953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="209" mass="23701" checksum="D66F1C3CF54662A3" modified="2016-04-13" version="1">MEFVGLQNLVLDNESWVVKIRICKLCKSLNIKRNGEFISLDMVLIDENGSLMTTMVRKNLVNKFNLLFKEGNVWLRISAFKVIDSNLKIIFTLLTKVEKIDTHVPSIPIHGFQLASEKIINDRLNDDNILTAAVGDVETMRGGFRKRDSEIISRLFKLYLSVRNDTGVVNCVVLHKLAERMVDSSPLKLLNKSDSDKDNLPHEITSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YME2</accession>
    <name>A0A103YME2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000049">
        <property type="protein sequence ID" value="KVI11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YME2"/>
    <dbReference type="STRING" id="59895.A0A103YME2"/>
    <dbReference type="Gramene" id="KVI11723">
        <property type="protein sequence ID" value="KVI11723"/>
        <property type="gene ID" value="Ccrd_009866"/>
    </dbReference>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003551">
        <property type="entry name" value="Signal recognition particle receptor alpha subunit family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000007">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000016">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="603" mass="66008" checksum="285C11E283C5707E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN13</accession>
    <name>A0A103YN13_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000016">
        <property type="protein sequence ID" value="KVI12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN13"/>
    <dbReference type="STRING" id="59895.A0A103YN13"/>
    <dbReference type="Gramene" id="KVI12068">
        <property type="protein sequence ID" value="KVI12068"/>
        <property type="gene ID" value="Ccrd_009506"/>
    </dbReference>
    <dbReference type="OMA" id="KTTNPMW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009511">
        <property type="term" value="C:plasmodesmatal endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048574">
        <property type="term" value="P:long-day photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009911">
        <property type="term" value="P:positive regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048578">
        <property type="term" value="P:positive regulation of long-day photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd08378">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04019">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000119">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000128">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047257">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047258">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF37">
        <property type="entry name" value="FT-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="733"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="198"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="358"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="791" mass="90925" checksum="D2F6187F88291D16" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNH6</accession>
    <name>A0A103YNH6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000005">
        <property type="protein sequence ID" value="KVI12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNH6"/>
    <dbReference type="STRING" id="59895.A0A103YNH6"/>
    <dbReference type="Gramene" id="KVI12381">
        <property type="protein sequence ID" value="KVI12381"/>
        <property type="gene ID" value="Ccrd_009202"/>
    </dbReference>
    <dbReference type="OMA" id="YIYYSST"/>
    <dbReference type="OrthoDB" id="670255at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF72">
        <property type="entry name" value="AP2 DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="214" mass="23738" checksum="59218AFDE046C189" modified="2016-04-13" version="1">MDASVALHRSSDDSRKSPWSPEDDLLFRQDSLPFNSNDSEDMLLFDILAADLADQSSESNSSTIADEVSSQSKPVNHKSYRGVRRRPWGKFAAEIRDSTRNGVRVWLGTFDSAEEAAMAYDEAAFSMRGSLAVLNFPVERVKESLKKMKYGFEEGSSPVVVLKKRHSQRCKREEKVVAGDGDGEKVTMVLEDLGADYLDQLLSSSETGKNTSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNQ4</accession>
    <name>A0A103YNQ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNQ4"/>
    <dbReference type="STRING" id="59895.A0A103YNQ4"/>
    <dbReference type="Gramene" id="KVI12459">
        <property type="protein sequence ID" value="KVI12459"/>
        <property type="gene ID" value="Ccrd_009084"/>
    </dbReference>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="374"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="595"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="690" mass="79951" checksum="D1AA81835DC234E4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNU2</accession>
    <name>A0A103YNU2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNU2"/>
    <dbReference type="STRING" id="59895.A0A103YNU2"/>
    <dbReference type="Gramene" id="KVI12519">
        <property type="protein sequence ID" value="KVI12519"/>
        <property type="gene ID" value="Ccrd_009117"/>
    </dbReference>
    <dbReference type="OMA" id="TDDCLEM"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010011">
        <property type="term" value="F:auxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010152">
        <property type="term" value="P:pollen maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000006">
        <property type="entry name" value="Transport inhibitor response 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000029">
        <property type="entry name" value="Transport inhibitor response 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041567">
        <property type="entry name" value="COI1_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041101">
        <property type="entry name" value="Transp_inhibit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF66">
        <property type="entry name" value="PROTEIN TRANSPORT INHIBITOR RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18511">
        <property type="entry name" value="F-box_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18791">
        <property type="entry name" value="Transp_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="589" mass="66531" checksum="FB141E634EA02255" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRZ7</accession>
    <name>A0A118JRZ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_024968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005872">
        <property type="protein sequence ID" value="KVH87746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRZ7"/>
    <dbReference type="Gramene" id="KVH87746">
        <property type="protein sequence ID" value="KVH87746"/>
        <property type="gene ID" value="Ccrd_024968"/>
    </dbReference>
    <dbReference type="OMA" id="ERTINFP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42454" checksum="29D414FA08318F5F" modified="2016-04-13" version="1">MVPSTERLSLPVSDPSPQQRGGAGEQRLFKGSAMTTRGAYAAVSYMSCAGMRHMGYGLCFDFTVLLVLFNKAALSSYSFPSANVITLFQMICSCSFLYVLRCWKLISFSSGDISPLTDNSARFVSLQTVIHTSPLALTYLLYMLATMESVRGVNVPMYTTLRRTTVVFTMFVEFILVGQKYTRSVIGSYVLDCFVVVDIIVSYAVRLSAFNCFISVALIVFGAFVAGSRDLSFDAYGYAVVFLSNITTAIYLATISRVGKSSGLNSFGLMWCNGILCGPVLLFWTFIRGDLRMTMDFPYLFAPGFLIVLLLSCVLAFFLNYSIFLNTTLNSAVTQTICGNLKDLFTITLGWMFFGGLPFDLLNVIGQLLGFVGSGFYAYFKLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS31</accession>
    <name>A0A118JS31_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_026588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005382">
        <property type="protein sequence ID" value="KVH88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS31"/>
    <dbReference type="STRING" id="59895.A0A118JS31"/>
    <dbReference type="Gramene" id="KVH88537">
        <property type="protein sequence ID" value="KVH88537"/>
        <property type="gene ID" value="Ccrd_026588"/>
    </dbReference>
    <dbReference type="OMA" id="PWQTFIK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF38">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="205" mass="23728" checksum="31BF3C77FB6A501B" modified="2016-04-13" version="1">MELELSLSPPYQKTPSIINKSFHGGDDDRCSSTVTRFPRVSWNQDEDDDNNKRFFNGEYQQDMDGDGEGLIGWPPLHSWRKRFMEENHSGGEGFNGRVDEEGENINVMNNNYNELLFVKVKMDGVGIARKIDLNAIHSYQMLTSTLIHMFHKYVENDEDGASYKLMYQHKDGHWLLAGDIPWEYDVHSDSTTYTNGKKVMLMDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSD0</accession>
    <name>A0A118JSD0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005323">
        <property type="protein sequence ID" value="KVH88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSD0"/>
    <dbReference type="STRING" id="59895.A0A118JSD0"/>
    <dbReference type="Gramene" id="KVH88974">
        <property type="protein sequence ID" value="KVH88974"/>
        <property type="gene ID" value="Ccrd_024231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="64" mass="7148" checksum="8470EC27BC98CF40" modified="2016-04-13" version="1">MEDIRTGTGDRQVVFGKYEIGRLFGPKNVKVYHTRDLVMAEGVVVIVIKTEQVKKEGLMVKSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTY2</accession>
    <name>A0A118JTY2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Pectinesterase</fullName>
            <ecNumber evidence="5 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_006764</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
            <location evidence="1 12">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 12"/>
    <dbReference type="EMBL" id="LEKV01005068">
        <property type="protein sequence ID" value="KVH91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTY2"/>
    <dbReference type="STRING" id="59895.A0A118JTY2"/>
    <dbReference type="Gramene" id="KVH91211">
        <property type="protein sequence ID" value="KVH91211"/>
        <property type="gene ID" value="Ccrd_006764"/>
    </dbReference>
    <dbReference type="OMA" id="DIQSWCN"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6 12" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="13">
        <location>
            <begin position="44"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="507" mass="54750" checksum="91BAC0C6279D5BCA" modified="2016-04-13" version="1">MQLPTTKTISKTSLLFLSEMPIFPFLVTLISCLFLLISPGVFGYSISEIRSWCSQTPHPESCESVLAGKPNYGPLSQKPDFIKALVKVTLERAADAESNTRGLGAKCRNNLEKAAWKDCLELYENTVWRINMTVDPNRKCSQNEMQTWLSTALTNLETCRAGFEELGVGGYLLPLMKNNVSALISNTLAMNKGGSPPETYPNGFPSWVKPGDRKLLQSSNPGSQANSVVAQDGSGNYKTIGAAVAAAKSGGGRYVIYVKAGTYNEYVQIGSGLKNLMIIGDGIGKTIITGSKSVGGGSTSFNSATFAVALRSGSDLSVFYQCSFEGYQDTLYALSNRQFYRQCDIYGTVDFIFGNAAVVLQSCNIYARDPPNKTNTLTAQGRTDPNQNTGISIHNCRVTGVSSLSGVKTFLGRPWKQYSRTVYLKTYLDGIVNPAGWMPWSGNFALDTLYYGEYMNTGPGSSTANRVNWKGYRVITSAAEAGKFTVGSFIAGGSWLPATGVAYTSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV67</accession>
    <name>A0A118JV67_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01004747">
        <property type="protein sequence ID" value="KVH93564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV67"/>
    <dbReference type="STRING" id="59895.A0A118JV67"/>
    <dbReference type="Gramene" id="KVH93564">
        <property type="protein sequence ID" value="KVH93564"/>
        <property type="gene ID" value="Ccrd_004389"/>
    </dbReference>
    <dbReference type="OMA" id="VMEGMME"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF429">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1 ISOZYME 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="324" mass="36930" checksum="97DDAB6297F674DF" modified="2016-04-13" version="1">MSMMVMEGMMEKGVLEDIIKRLLEGRGGKQVQLSEVEIRQLCVNARQIFLSQPNLLHLHAPIRICGDIHGQYQDLLRLFEYGGYPPSQNYLFLGDYVDRGRQSLETICLLLAYKIRYPDKVFLLRGNHEDAKINRIYGFYDECKRRFNVRLWKIFTDCFNSLPVAALVDEKILCMHGGLSPELENLNQIQEIERPTEIPDNGLLCDLLWSDPDPTIEGWSDSDRGVSCTFGADKVVEFLGKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNVGALLSVDKSLVCSFEILKPLDYAEKPGTSRLPLKKPPKTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVB5</accession>
    <name>A0A118JVB5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_005706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004827">
        <property type="protein sequence ID" value="KVH92260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVB5"/>
    <dbReference type="STRING" id="59895.A0A118JVB5"/>
    <dbReference type="Gramene" id="KVH92260">
        <property type="protein sequence ID" value="KVH92260"/>
        <property type="gene ID" value="Ccrd_005706"/>
    </dbReference>
    <dbReference type="OMA" id="IRTWTCT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="250"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH92260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="427" mass="48592" checksum="CEDA638F7F1F00BC" modified="2016-04-13" version="1">MTVMGFCVPSRDTSDRFSDRCSNVFPCLSDPARRSTMCLKLALVMLHLIFVGFLFIVDDELKEKSKEQPLYTLIYMLLVIATLVQYFLTSGSSPGYVLDAMRDFARTEALLRASEISKSNCRIFLCLLMQMIKQRQPASSKNGSVVLTVNRNQVGESLLGNNPMNWTKLVMDMYPPGTSVRTYTCSYCNVVQLVPAEAIGELFATCLLLTRPPCTFGSVCEQMVRADLQRFNIIEGSNYVSATEASAVFTNVNLPPRAKHCHDCDRCVLQFDHHCVWLGTCIGQGNHCRFWWYILEETALSIWTGILYIKYLQAHIDKAWLVDVIMIILLSILSIALIFLLLLLLFHSYLVVTNQTTYELVRRRRIPYMRAIPERVYPFSKGACRNLYNFCCARTSIYRMEVLPSAAELDQKSVPYTCVDVISCRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVR3</accession>
    <name>A0A118JVR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004643">
        <property type="protein sequence ID" value="KVH93657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVR3"/>
    <dbReference type="STRING" id="59895.A0A118JVR3"/>
    <dbReference type="Gramene" id="KVH93657">
        <property type="protein sequence ID" value="KVH93657"/>
        <property type="gene ID" value="Ccrd_004292"/>
    </dbReference>
    <dbReference type="OMA" id="AIRELWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057136">
        <property type="entry name" value="At2g35280_TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044508">
        <property type="entry name" value="At5g50450/At1g67340-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758:SF17">
        <property type="entry name" value="F-BOX DOMAIN, ZINC FINGER, MYND-TYPE, TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758">
        <property type="entry name" value="MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23310">
        <property type="entry name" value="TPR_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g35280-like TPR" evidence="1">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24846" checksum="B71B6EE567096AD6" modified="2016-04-13" version="1">MTKKLCEGEVVHHGRRRRRSDLFESSPDEIVISILCNLSSTFSSSSDFVTVLLTCKRLNKLGVHPLVLSNACSETLAVGAKNWSDEAHRFLKLCVNAGNKEAYYTLGMIRFCCLQNRGSGASLMVKAAIKSHVPALYSLALIQFNGSGGLKNDKDLRAEVALCARAAFLGHADAIRELWHCLQDGYGVRKNVEEGRRLLVQANAHELSCIFHPFQLNRRRHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWN5</accession>
    <name>A0A118JWN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WUS homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004545">
        <property type="protein sequence ID" value="KVH94587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWN5"/>
    <dbReference type="STRING" id="59895.A0A118JWN5"/>
    <dbReference type="Gramene" id="KVH94587">
        <property type="protein sequence ID" value="KVH94587"/>
        <property type="gene ID" value="Ccrd_003346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044555">
        <property type="entry name" value="WUSCHEL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45940">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45940:SF42">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="176" mass="20201" checksum="093908DB40919EA1" modified="2016-04-13" version="1">MQNEGDDDINQITHSLYKYPFTPQPHYNQTHKPELKKMTAMETVLSRSLSGGGGGGGGGSRWCPTPEQVMLLEGMYRGGLKTPTATQIQQITARLSLYGKIQGKNVFYWFQNHKARDRQKLRKKLMSIYQHQRLYSPYHHSLPIQGGVIEDTSSCKNRVNKWKVDPHVDQTCNFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWV3</accession>
    <name>A0A118JWV3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004280">
        <property type="protein sequence ID" value="KVH96502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWV3"/>
    <dbReference type="STRING" id="59895.A0A118JWV3"/>
    <dbReference type="Gramene" id="KVH96502">
        <property type="protein sequence ID" value="KVH96502"/>
        <property type="gene ID" value="Ccrd_001415"/>
    </dbReference>
    <dbReference type="OMA" id="NWSTISV"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000002">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000040">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="530" mass="58337" checksum="96580EECAA2A3C42" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Q8</accession>
    <name>A0A118K0Q8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toll/interleukin-1 receptor homology (TIR) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002692">
        <property type="protein sequence ID" value="KVI01740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Q8"/>
    <dbReference type="Gramene" id="KVI01740">
        <property type="protein sequence ID" value="KVI01740"/>
        <property type="gene ID" value="Ccrd_019977"/>
    </dbReference>
    <dbReference type="OMA" id="SATCAYH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32009:SF154">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32009">
        <property type="entry name" value="TMV RESISTANCE PROTEIN N-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="18444" checksum="C9061DE104AAB714" modified="2016-04-13" version="1">MDILHPSSSATCAYHIFLSFNCADIRKHFTDHLYTAFCNAGFHTFRDDHEIQKRQRIDSMMSVIVFSREYASSEWCLDELVRILQRRNSDDRHRLFPIFYNVEPTEVGYQKGSFKECFDRYEGSGEHSKEKIDEWREALKEVSKLTGKVLQDEYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1D0</accession>
    <name>A0A118K1D0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_019169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1D0"/>
    <dbReference type="STRING" id="59895.A0A118K1D0"/>
    <dbReference type="Gramene" id="KVI02490">
        <property type="protein sequence ID" value="KVI02490"/>
        <property type="gene ID" value="Ccrd_019169"/>
    </dbReference>
    <dbReference type="OMA" id="CEDRECI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="49"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="236"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="48294" checksum="B8DA1F4DC5FED3DC" modified="2016-04-13" version="1">MRECISVHIGQAGIQVGNSCWELYCLEHGLQPDGQMPGDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFHAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVSVLLDNEAIYDICRKSLDIERPTYTNLNRLVSQVFDKIPFQTNLVPYPRIHFMLSSYAPVISSEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLESVDNEDDDDGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3G5</accession>
    <name>A0A118K3G5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3G5"/>
    <dbReference type="STRING" id="59895.A0A118K3G5"/>
    <dbReference type="Gramene" id="KVI05943">
        <property type="protein sequence ID" value="KVI05943"/>
        <property type="gene ID" value="Ccrd_015696"/>
    </dbReference>
    <dbReference type="OMA" id="MVDVIKQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF53">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH68-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="37832" checksum="403BC4CDD12310B8" modified="2016-04-13" version="1">MMGENPNYWWSLNGKLQPPPSQQAYPNFLSSPPLPAPPPPPPPSSVLNPPYLFGSSLLLPAANSNALPDHQHHDNQDFPVSWSQLLLTGLAHDQEEHNLGGGHVGEVKHGYLNQQSRQLYYSNKNDHHDNNNNDEDLQACSSSWSSQLNPVPSVGSSSTMSLSTTTMFDFSSKIDSRNQHTNQYSSQYDDTSTSGAPKKPRFQSYSTQPSPTCNETFTSGTSKRARAQHSSTQTPLKVRKEKLGERISSLHQLVSPFGKTDTASVLLEATAHIRFLESQIEALTSPYMNSSGATRHQHSADGKALQKDLGSRGLCLVPVTCMDHLDTTNMTSNGAEFWTPALGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4W0</accession>
    <name>A0A118K4W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pectate lyase</fullName>
            <ecNumber evidence="3 8">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="3 8"/>
    <dbReference type="EMBL" id="LEKV01001232">
        <property type="protein sequence ID" value="KVI08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4W0"/>
    <dbReference type="STRING" id="59895.A0A118K4W0"/>
    <dbReference type="Gramene" id="KVI08147">
        <property type="protein sequence ID" value="KVI08147"/>
        <property type="gene ID" value="Ccrd_013485"/>
    </dbReference>
    <dbReference type="OMA" id="TWILAMI"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF130">
        <property type="entry name" value="PECTATE LYASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990290" description="Pectate lyase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="9">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="38862" checksum="D3AAADF5774E5762" modified="2016-04-13" version="1">MAMVVVKKSVIGCSFLFLVSLLVFVAVAGAAQNEDNSNPRDVEEDQFHGLNISSFAARAKESQALNENAVQDPEEVVSMVEMSMRNSTERRKLGYFSCGTGNPIDDCWRFKTIDARGVNVHIANGACLTIQFITNVIVHGLHIHDCKPTGNALVRSSPSHYGWRTMADGDAISIFGSSHIWIDHNSLSNCADGLVDAVLGSTAITISNNYFTHHNERLVYEGQANASDYRLQPFWRRCRHGYFHVVNNDYTHWEMYAIGGSASPTINSQGNRYLAPVNPFAKEVTKRVDTAASQWHGWNWRSEGDLLLNGAYFTPSGAGASASYARASSLGAKSSSMVGTITSGAGVLGCRRGRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5F6</accession>
    <name>A0A118K5F6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Peroxidase</fullName>
            <ecNumber evidence="4 19">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_012678</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16 19">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="16 19">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 19"/>
    <dbReference type="EMBL" id="LEKV01001077">
        <property type="protein sequence ID" value="KVI08957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5F6"/>
    <dbReference type="STRING" id="59895.A0A118K5F6"/>
    <dbReference type="Gramene" id="KVI08957">
        <property type="protein sequence ID" value="KVI08957"/>
        <property type="gene ID" value="Ccrd_012678"/>
    </dbReference>
    <dbReference type="OMA" id="TWAKDNA"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000008">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF3">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 19" id="KW-0349">Heme</keyword>
    <keyword evidence="13 19" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="11 16 19" id="KW-0408">Iron</keyword>
    <keyword evidence="8 16 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 19 21" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0964">Secreted</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990293" description="Peroxidase" evidence="19">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="20">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="126"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI08957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="35633" checksum="DA7ED3E86C6BA487" modified="2016-04-13" version="1">MGRIAVIQVLALCSILLISLPNFASAQLRQNYYANICPNVETIVRNAVRAKVQQTFVTIPGTLRLFFHDCFVQGCDASVMIASSGSNTAEKDHQDNLSLAGDGFDTVVKAKAAVDAVASCRNKVSCADILTMATRDVVMMAGGPSYPVELGRLDGLSSTAASVGGKLPKPNLNLNQLNAMFAANGLTQSDMIALSGAHTLGFSHCDQFANRIYNFSKQNAVDPTLSPSYATQLQQQCPKNVDPRIAINMDPNTPRTFDNVYFKNLQQGQGLFTSDQVLFTDSRSKPTVNTWASNAQAFNNAFITAMTKLGRVGVKTSKNGNIRLDCSRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5Z3</accession>
    <name>A0A118K5Z3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001038">
        <property type="protein sequence ID" value="KVI09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5Z3"/>
    <dbReference type="STRING" id="59895.A0A118K5Z3"/>
    <dbReference type="Gramene" id="KVI09887">
        <property type="protein sequence ID" value="KVI09887"/>
        <property type="gene ID" value="Ccrd_011737"/>
    </dbReference>
    <dbReference type="OMA" id="TMTVCYP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="298"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="43759" checksum="611AB5710214CFED" modified="2016-04-13" version="1">MQTEARVGVEGGGPAHKLVTRHQRPLQHHGSQIGAIHQLIAGGVAGAVSKTCTAPLARLTILFQVQGMHSDVSTLRKASIWHEASRIIREEGFRAFWKGNLVTITHRLPYSSISFYAFEHYKNVGTNALSWKFLHLNIDFLCNLTVIRFDNSLCSLLMLQLLQQMSGVETHETNFGNDVFVRLAAGGLAGVTAASVTYPLDLIRTRLSAQVRIFGMHFICIFFFFSLLLIHLLVLQTNVNYYRGIWHALHTISREEGIFGLYKGLGACLLGVGPNLAISFSVYHTARSYWQLQRPDDSTVMVGLACGSLSGIASSTVSFPLDLVRRRMQLEGAAGWGQVYKTGVLGTFGHILRAEGLRGLYRGILPEYYKVVPSIGIVFMTYEKLKQVLSDIDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124R3M6</accession>
    <name>A0A124R3M6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008164">
        <property type="protein sequence ID" value="KVG42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124R3M6"/>
    <dbReference type="Gramene" id="KVG42980">
        <property type="protein sequence ID" value="KVG42980"/>
        <property type="gene ID" value="Ccrd_026419"/>
    </dbReference>
    <dbReference type="OMA" id="GKLHMER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVG42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="35038" checksum="F1790E4BFD49D16D" modified="2016-04-13" version="1">MEEVSNKQVVLKDYVNGFPKESDMLINTSATISLNLPQGSNALLVKNLYLSCDPYMRNRMTKTEDSYVPSFTPGSPMEGFGVAKVLDSGHANFKKGDLFWGITGWEEYSIITAPESVFKIEHTDVPLSYYTGILDEMVNACNFSPSKREPFISIQQSSMPGMTAYFGFYEICAPKKGECVFVSAASGAVGQLVGQFAKLLGCYNVGGKMLEAVLLNMRLHGRISVCGMISQYNLEQGDGVRNLFCLVSKRLSMKGFIVADHYHLYPKYMEMVIPLIKQGKICYIEDIVEGLESTPVTLVGLFSGRNVGKQVVVVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAJ3</accession>
    <name>A0A124SAJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Late embryogenesis abundant protein, LEA-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005934">
        <property type="protein sequence ID" value="KVH87685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAJ3"/>
    <dbReference type="STRING" id="59895.A0A124SAJ3"/>
    <dbReference type="Gramene" id="KVH87685">
        <property type="protein sequence ID" value="KVH87685"/>
        <property type="gene ID" value="Ccrd_025036"/>
    </dbReference>
    <dbReference type="OMA" id="HCDEKEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31415:SF20">
        <property type="entry name" value="NDR1_HIN1-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31415">
        <property type="entry name" value="OS05G0367900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="6">
        <location>
            <begin position="82"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH87685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="264" mass="29499" checksum="BDCC5BA1A147F744" modified="2016-04-13" version="1">MSQIHAKSPQHCAKKKLVNINNLHKKLLYTFTTFFSSILLLILLVWFILHPAKPHFSLKEADIYQLVVSGTHLLNSSIQLTLLSTNPNQKVGIYYEEIQVYASYKAQQITLHSYLPPFYQDHKDTNLLSAALVANSLPVAPSFNYELGRDQTAGRLVLNLKANGLLRWKVGTWVSGRYRFYVNCVAVMVFGPSAPAGNGSPHQSTLRSIVHNTLIMQPSQKWVGLLALSSSSTFILTIPATPKQFIGNSNGYKHQLTAEGNHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBI8</accession>
    <name>A0A124SBI8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005093">
        <property type="protein sequence ID" value="KVH90792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBI8"/>
    <dbReference type="Gramene" id="KVH90792">
        <property type="protein sequence ID" value="KVH90792"/>
        <property type="gene ID" value="Ccrd_007196"/>
    </dbReference>
    <dbReference type="OMA" id="KAQKYQI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040389">
        <property type="entry name" value="SMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142:SF8">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13513" checksum="BA77B8E42D130633" modified="2016-04-13" version="1">MAPSRKSARKPRRTIKKKQLETKEEISNITASPVKTCSDNSVLKKMDHEISSIGCTTPKAQKYQIPEILTCPPAPKKRRLVSSCTLRRTPISFFDPPDIELFFASHLASIYNHVHTHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBV3</accession>
    <name>A0A124SBV3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBV3"/>
    <dbReference type="STRING" id="59895.A0A124SBV3"/>
    <dbReference type="Gramene" id="KVH91827">
        <property type="protein sequence ID" value="KVH91827"/>
        <property type="gene ID" value="Ccrd_006176"/>
    </dbReference>
    <dbReference type="OMA" id="ICNGFRI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000307">
        <property type="entry name" value="Phosphatidylinositol 4-kinase gamma 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="243"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="529" mass="58465" checksum="927FF8B3EE5642CF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC58</accession>
    <name>A0A124SC58_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004807">
        <property type="protein sequence ID" value="KVH92740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC58"/>
    <dbReference type="STRING" id="59895.A0A124SC58"/>
    <dbReference type="Gramene" id="KVH92740">
        <property type="protein sequence ID" value="KVH92740"/>
        <property type="gene ID" value="Ccrd_005218"/>
    </dbReference>
    <dbReference type="OMA" id="KWNGNAT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558:SF19">
        <property type="entry name" value="PROTEIN ENHANCED DISEASE RESISTANCE 2 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="221"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="48327" checksum="0825A131AA43D4FC" modified="2016-04-13" version="1">MGVCGSKAKGCVGVGLGHKKRGDVADGETTPKLQARTHGRRRRRRLGRKSKTDATNRFSSRNKVDPSAVTSNSMDRRSYRNPTFQGGIQNLGMILRLGLIPMGMKISTALKMNGSISASVTPRFSDHVNNATFSASDSLIKPSEVPPSSIDGASVVYDNGSQNFGILQNNCLPCLNCTTSTDVKSKSPCSSPPSAKKKVTSMLSFKWREGQSNLSKLSDSWSPLEPSTFKVRGHNYLRDKKKESAPNQAAFYPIGVDVFLSPRKIDHIARLLELPTIESSGKIPSLLVVNLQLSENYEELPLHFQENIRKMIDDEVERVRGFPVDTIAPCRERLKILGRITNLEDLHLSAAERKLMNAYNEKPGENYFEIDLDMHRFSYISRKGFGAFQERLKHCNLDFGLTIQGTKGEELPECILCCLHLKEIDYNNYSLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCZ1</accession>
    <name>A0A124SCZ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane insertase OXA1/ALB3/YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCZ1"/>
    <dbReference type="STRING" id="59895.A0A124SCZ1"/>
    <dbReference type="Gramene" id="KVH95302">
        <property type="protein sequence ID" value="KVH95302"/>
        <property type="gene ID" value="Ccrd_002600"/>
    </dbReference>
    <dbReference type="OMA" id="AMTQDHT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF34">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="368" mass="40641" checksum="E00E5E2F1EE4CB3E" modified="2016-04-13" version="1">MAYRRSLATKTRLFSQQRFAPSFSYVHHEDDRKNQYSDEKIWSALQSSRSFSCVGNTTKTSLGFGGGGGSGSFRDPRWSQFLHVPMTTSGFLLSRNMSTTIGDGSGAEKIEYMADVADILADKTMEVVSTQAPAVSEVAVAAADSWLPVAALQYAIDGIHNFTGMNWCFCQIVISEQDDQARWGILRPELEQIKQEMQDKGMSPSAVAEGQAKMKRVFSEHGVSTFTPLKGLFIQGPVFVSFFLAIQNMVEKVPSFKTGVIKRPNVKKLLNIPIIVPPPPSATSQSQPAFSFFEGLKKYAAAQAMKQHEPKPTTTSQSTTSTPLLSHNKPSSEENKYTNGKVSSSSVLSHRIKNLEKEVKGRKKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDJ4</accession>
    <name>A0A124SDJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003853">
        <property type="protein sequence ID" value="KVH97147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDJ4"/>
    <dbReference type="Gramene" id="KVH97147">
        <property type="protein sequence ID" value="KVH97147"/>
        <property type="gene ID" value="Ccrd_000761"/>
    </dbReference>
    <dbReference type="OMA" id="CETETRI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48152">
        <property type="entry name" value="F1C9.34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48152:SF9">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176171" evidence="2">
        <location>
            <begin position="25"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="584" mass="63492" checksum="6F94F68076917A73" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF52</accession>
    <name>A0A124SF52_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein VTE6, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002662">
        <property type="protein sequence ID" value="KVI02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF52"/>
    <dbReference type="STRING" id="59895.A0A124SF52"/>
    <dbReference type="Gramene" id="KVI02143">
        <property type="protein sequence ID" value="KVI02143"/>
        <property type="gene ID" value="Ccrd_019577"/>
    </dbReference>
    <dbReference type="OMA" id="ILAVFMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29709" checksum="48F9AB5EF1C1D4C4" modified="2016-04-13" version="1">MATTPLTTIPITLSSLTLRRRRCTNFSSFFRPAKKPLICTFTSNLVKASAMESSFSSTRVQSSGGSSVPDLGLVQRAIQLAQLSPPTWQSAIFSNLVIFLLGSPILVTGLSLSGIGAAFLLGTLTWRGFGPSGFLLVATYFIIGTAVTKVKMAQKEAQGVAEKRKGRRGPGSVIGSSAAGCVCALLSIYGVGGKPFSRLWELGFVASFCTKLSDTIKVAEAVICVLASQIANVGESVIGAALQEKEGFKWLNNDAVNVINISLGSMLAILIQQVVLQNWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFF8</accession>
    <name>A0A124SFF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LMBR1-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002505">
        <property type="protein sequence ID" value="KVI03133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFF8"/>
    <dbReference type="STRING" id="59895.A0A124SFF8"/>
    <dbReference type="Gramene" id="KVI03133">
        <property type="protein sequence ID" value="KVI03133"/>
        <property type="gene ID" value="Ccrd_018573"/>
    </dbReference>
    <dbReference type="OMA" id="PCHERSA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="48874" checksum="E669FB1EB6D6AC87" modified="2016-04-13" version="1">MWVFYLISLPLTLGMVVLTLKYFAGPDVPRYVFFTVGYTWFCSISVIILVPADISATIIGHDNGGISFFWSWSYWSTFLLTWLVVPLIQGYEDAGDFTVRERLKTSIHVNLVFYLILGLIGSGGVLGLAMACSNTFGLVTGAFLLGFGLSEIPKTIWRNADWTSRQKVLSHKIAKMAVKLDEAHQELSNAIAVAQATSKQMSKHDPLRPYMNIIDNLLNQMLREDPSFKPQGGCLGENDMDYDTDEKSMATLRRHLRGAREEYYRYKSEYLTYVMEALKLEDTIKNYNQRNETGWYGKVGQTEDEGFRFWFRLEDFLLLLFFVISIRVSSSIIPLSIFHIKLLEVFLLVAVIECKKSKGKMASNFVAARVACLKVCQLLSESGFTSFRTNETFWLLSSSDASTKVLKNGNEPRGISYVRREPHKNKTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG78</accession>
    <name>A0A124SG78_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance protein RPS4B/Roq1-like leucine-rich repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG78"/>
    <dbReference type="Gramene" id="KVI05552">
        <property type="protein sequence ID" value="KVI05552"/>
        <property type="gene ID" value="Ccrd_016170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058546">
        <property type="entry name" value="RPS4B/Roq1-like_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083:SF65">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPP8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23286">
        <property type="entry name" value="LRR_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein RPS4B/Roq1-like leucine-rich repeats" evidence="4">
        <location>
            <begin position="74"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="517" mass="59370" checksum="6AEC65EDE7DAD672" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHP0</accession>
    <name>A0A124SHP0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding lysin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001028">
        <property type="protein sequence ID" value="KVI10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHP0"/>
    <dbReference type="STRING" id="59895.A0A124SHP0"/>
    <dbReference type="Gramene" id="KVI10142">
        <property type="protein sequence ID" value="KVI10142"/>
        <property type="gene ID" value="Ccrd_011496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33648">
        <property type="entry name" value="EMBRYO SAC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33648:SF15">
        <property type="entry name" value="OS04G0572800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="22827" checksum="DD9C9CFF8C02CBDE" modified="2016-04-13" version="1">MGDELMKARGVAKTVLGIADAVSFYCAITIVALMLTGAFRGDDSYGLTTTTSTSSVRVTGGGGNRRPCDEIYVVGEGETLHSISDKCDDPFIVEKNPHIHDPDDVFPGLFMASSRSPVTYADAAQWYCIIFLVLLVLLGSFTEENSLINKTNSTSYHACDEIYVVGEGETLNTISDKCGDPFIVEENPHIHDPDDVFPGLVIKITPSSPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5D2</accession>
    <name>A0A103D5D2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011629">
        <property type="protein sequence ID" value="KVD98166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVD98166">
        <property type="protein sequence ID" value="KVD98166"/>
        <property type="gene ID" value="Ccrd_024136"/>
    </dbReference>
    <dbReference type="OMA" id="FHETESM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001722">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006">
        <property type="entry name" value="PROMASTIGOTE SURFACE ANTIGEN PROTEIN PSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006:SF562">
        <property type="entry name" value="REPEAT TRANSMEMBRANE PROTEIN KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVD98166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17442" checksum="4D83020849FDAF5A" modified="2016-04-13" version="1">MMMFICSGYMSPEYALNGLFSVKSDVFSFGVVVLEIISGKXNTGYYQNQQAFSLISYAWGLWKDKTPIDLLDQALAESCNSSEVLRCMIIGLLCIQEDPQDRPTMMEVILMLGMDIESLPDPKEPAFVSKTRVDCMQTSSSKSEINQLTITDVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103P9Y2</accession>
    <name>A0A103P9Y2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SOSEKI DIX-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SOSEKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008358">
        <property type="protein sequence ID" value="KVG27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103P9Y2"/>
    <dbReference type="STRING" id="59895.A0A103P9Y2"/>
    <dbReference type="Gramene" id="KVG27377">
        <property type="protein sequence ID" value="KVG27377"/>
        <property type="gene ID" value="Ccrd_026501"/>
    </dbReference>
    <dbReference type="OMA" id="MAEAFSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010369">
        <property type="entry name" value="SOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048351">
        <property type="entry name" value="SOK_DIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083:SF5">
        <property type="entry name" value="PROTEIN SOSEKI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083">
        <property type="entry name" value="UPSTREAM OF FLC PROTEIN (DUF966)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06136">
        <property type="entry name" value="SOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOSEKI DIX-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVG27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10524" checksum="A826121167059D1D" modified="2016-04-13" version="1">MEELQAFAKERSFKRKLMVAQVGSRDGGGQVRRVHIVYFLSRNGCTEHPHLFRVHHLSRNGVRLRDVKSWLSELRGNNMPEGFAWSYKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103T1T3</accession>
    <name>A0A103T1T3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007252">
        <property type="protein sequence ID" value="KVH02536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103T1T3"/>
    <dbReference type="STRING" id="59895.A0A103T1T3"/>
    <dbReference type="Gramene" id="KVH02536">
        <property type="protein sequence ID" value="KVH02536"/>
        <property type="gene ID" value="Ccrd_026008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH02536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="13006" checksum="097D0321EF1C5EB2" modified="2016-04-13" version="1">MIAQKAGTINLLGILLGGNFAEKDLCFFIAVFARMRIKLLVWRFECYEEEQFRHWKANSENQMLQLKKESWKCEFERHKLLALYQRQTQVLQRKIEETARATKKAKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103T8X5</accession>
    <name>A0A103T8X5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA/RNA helicase, DEAD/DEAH box type, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007171">
        <property type="protein sequence ID" value="KVH10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103T8X5"/>
    <dbReference type="Gramene" id="KVH10518">
        <property type="protein sequence ID" value="KVH10518"/>
        <property type="gene ID" value="Ccrd_025955"/>
    </dbReference>
    <dbReference type="OMA" id="LHHVEEI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="537" mass="60429" checksum="717C7DD7845ECE8E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VYM6</accession>
    <name>A0A103VYM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006646">
        <property type="protein sequence ID" value="KVH62481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VYM6"/>
    <dbReference type="STRING" id="59895.A0A103VYM6"/>
    <dbReference type="Gramene" id="KVH62481">
        <property type="protein sequence ID" value="KVH62481"/>
        <property type="gene ID" value="Ccrd_025647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042293">
        <property type="entry name" value="ARID4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46694">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46694:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH62481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="14427" checksum="E78B95076E187FA2" modified="2016-04-13" version="1" fragment="single">MLATKSIGKGSFSQRCSVGNTPRRHYETYLLEYELAHDDVDGGVLLIRSGGFGYLGNGRISVVTEDRILVPLRYACKLLLSVSFNYIPRVWDVVHHKGGNVWLDHMDCLLQLKTLLEQQWHNIVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WWF8</accession>
    <name>A0A103WWF8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01006464">
        <property type="protein sequence ID" value="KVH79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WWF8"/>
    <dbReference type="STRING" id="59895.A0A103WWF8"/>
    <dbReference type="Gramene" id="KVH79763">
        <property type="protein sequence ID" value="KVH79763"/>
        <property type="gene ID" value="Ccrd_025502"/>
    </dbReference>
    <dbReference type="OMA" id="FSAREWS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001417">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="466" mass="52439" checksum="1532642656E09812" modified="2016-04-13" version="1">MDHVIGGKFKLGRKIGSGSFGELYLGVNVQSGEEVAVKLESVKTKHPQLHYEAKLYMLLQGGTGVPHLKWIGVEGEYNAMVIDLLGPSLEDLFNYCNRKFTLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANQASIDEPDSGIPIHSSGSISSFVLYSFHVKNAAAYLPVQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKRLTPIEVLCKSYPTEFISYFHYCRSLRFDDKPDYSYLKRLFRDLFIREGYQFDYVFDWTILKYPQIGSGSSSRGRTVGKLPLNPGPSAERVEKTPGLIFLSHGDSDRGRISRTGSTSKRAIVSSSRPSSSGEPSESRSNRLGSGSGRISTNQRIHSQPGFESKSSSFSRAVPSSRGGRDDALRSFELLTIGNTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X6E1</accession>
    <name>A0A103X6E1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">X8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006364">
        <property type="protein sequence ID" value="KVH84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X6E1"/>
    <dbReference type="STRING" id="59895.A0A103X6E1"/>
    <dbReference type="Gramene" id="KVH84930">
        <property type="protein sequence ID" value="KVH84930"/>
        <property type="gene ID" value="Ccrd_025441"/>
    </dbReference>
    <dbReference type="OMA" id="GMANCKA"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000001">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044788">
        <property type="entry name" value="X8_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044">
        <property type="entry name" value="BETA-1,3 GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044:SF36">
        <property type="entry name" value="CARBOHYDRATE-BINDING X8 DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118630" evidence="9">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="164" mass="17691" checksum="8578BF6C64C3E525" modified="2016-04-13" version="1">MIAFQTLLLVPCYLYVVMVGAIRVEDRVEETLLSPPEGNMTFLDGTNWCVASPGATQYDLQSALDWACGLGMTDCSQIRPGGPCYQPDTLFSHASFAFNSYYQQNGNSDVACNFGGSATLTKNNPSYGKCVYAASGPAKSGGGLVWRLNWWKSGGILLLLYMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDJ8</accession>
    <name>A0A103XDJ8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycerol-3-phosphate acyltransferase, chloroplastic</fullName>
            <shortName evidence="14">GPAT</shortName>
            <ecNumber evidence="14">2.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_025864</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate. The enzyme from chilling-resistant plants discriminates against non-fluid palmitic acid and selects oleic acid whereas the enzyme from sensitive plants accepts both fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Plastid</location>
            <location evidence="1 14">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="14"/>
    <dbReference type="EMBL" id="LEKV01005342">
        <property type="protein sequence ID" value="KVH88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDJ8"/>
    <dbReference type="STRING" id="59895.A0A103XDJ8"/>
    <dbReference type="Gramene" id="KVH88745">
        <property type="protein sequence ID" value="KVH88745"/>
        <property type="gene ID" value="Ccrd_025864"/>
    </dbReference>
    <dbReference type="OMA" id="IAENMIY"/>
    <dbReference type="OrthoDB" id="524544at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07985">
        <property type="entry name" value="LPLAT_GPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1130.10">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.50">
        <property type="entry name" value="Glycerol-3-phosphate acyltransferase, alpha helical bundle, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016222">
        <property type="entry name" value="G3P_O-acylTrfase_chlp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023083">
        <property type="entry name" value="G3P_O-acylTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038114">
        <property type="entry name" value="GPAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35695">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35695:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14829">
        <property type="entry name" value="GPAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000431">
        <property type="entry name" value="Glycerol-3-P_O-acyltransfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 14" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0934">Plastid</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="17">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif" evidence="15">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000431-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="447" mass="49811" checksum="EFF4D83402B5A3C9" modified="2016-04-13" version="1">MSILSPSHTLFFSTTNPRVSLSPSTSLSSRFRPIFRRFPCLVFSAPPNAAHGMAETVRDNKWSSSSSTQQPHSGSDHGYSRTFIDARSEQDLLSGIQREVEAGTLPKPVAQAMEELYQNYKNAVFQSGDPHAEDIVLSNMRIAFDRMFLDVKEPFEFSPYHEAILEPFNYYMFGQNYIRPLVNFRESYVGNVSLFGVMEEQLKQGENVVLISNHQTEADPAVIALMLETTNPHISENIIYVAGDRVITDPLCKPFSMGRNLLCVYSKKHMNDVPELAEMKKRSNTRSLKEMALLLRGGSKIIWIAPSGGRDRPDPNTNQWFPAPFDATSLDNMRRLVDHAGLVGHIYPLAILCHDIMPPPLQVEKEIGEKRLISFHGTGISVGPEINFQKATASCASPEEAKAAYSQALYDSVCEQYKVLHSAVHGAKGLEASTPSVSLSQPLQFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDL1</accession>
    <name>A0A103XDL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005334">
        <property type="protein sequence ID" value="KVH88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDL1"/>
    <dbReference type="SMR" id="A0A103XDL1"/>
    <dbReference type="STRING" id="59895.A0A103XDL1"/>
    <dbReference type="Gramene" id="KVH88808">
        <property type="protein sequence ID" value="KVH88808"/>
        <property type="gene ID" value="Ccrd_025410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048366">
        <property type="term" value="P:leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523:SF33">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="849" mass="97012" checksum="2462D166F912BE12" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEF0</accession>
    <name>A0A103XEF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005297">
        <property type="protein sequence ID" value="KVH89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEF0"/>
    <dbReference type="STRING" id="59895.A0A103XEF0"/>
    <dbReference type="Gramene" id="KVH89198">
        <property type="protein sequence ID" value="KVH89198"/>
        <property type="gene ID" value="Ccrd_008817"/>
    </dbReference>
    <dbReference type="OMA" id="RRSECKH"/>
    <dbReference type="OrthoDB" id="1026046at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374">
        <property type="entry name" value="AUXIN-INDUCED PROTEIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374:SF304">
        <property type="entry name" value="OS04G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="176" mass="19663" checksum="EE45F75FD6AD19A1" modified="2016-04-13" version="1">MKKIRGFLIKHRVFSLFRCIRRKSQTSPAGYRRLNPSSRSISKLLKWGAGIKAKATAICSKNPGFRWGYLRVGRDPIVEADPISPPHAAVPKGKMAVYIGQNDGGFERVLVPVIYINHPLFGQLLRKAEAEYGHDHAGGITIPCRISEFENVKTRIAAGCGGRKMLPWKRSNMSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF35</accession>
    <name>A0A103XF35_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acylneuraminate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005205">
        <property type="protein sequence ID" value="KVH89537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF35"/>
    <dbReference type="STRING" id="59895.A0A103XF35"/>
    <dbReference type="Gramene" id="KVH89537">
        <property type="protein sequence ID" value="KVH89537"/>
        <property type="gene ID" value="Ccrd_008479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42866">
        <property type="entry name" value="3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42866:SF2">
        <property type="entry name" value="3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21961" checksum="41CE927A381FB657" modified="2016-04-13" version="1">MEPESTAASGGDTTYSWPPAKGVAVYGVAITAAMAVGYAALYVRRSAKFRSQVVGIIPARYASSRFQGKPLVPILGKPMIQRTWERAKLATTLSQLVVATDDERIAECCRGFGAYVVMTSESCRNGTERCYEALLSLKKKFDIVISPTPLQLEEDLEQLKVLENGYKMKVIKVDHDAHGVDTPEDVEKIESLMRERNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFK1</accession>
    <name>A0A103XFK1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ternary complex factor MIP1, leucine-zipper</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005138">
        <property type="protein sequence ID" value="KVH89811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFK1"/>
    <dbReference type="STRING" id="59895.A0A103XFK1"/>
    <dbReference type="Gramene" id="KVH89811">
        <property type="protein sequence ID" value="KVH89811"/>
        <property type="gene ID" value="Ccrd_008220"/>
    </dbReference>
    <dbReference type="OMA" id="SSQMIEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054:SF26">
        <property type="entry name" value="ELECTRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ternary complex factor MIP1 leucine-zipper" evidence="3">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="485"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71035" checksum="6F7B780E48608B68" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFL8</accession>
    <name>A0A103XFL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005130">
        <property type="protein sequence ID" value="KVH89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFL8"/>
    <dbReference type="STRING" id="59895.A0A103XFL8"/>
    <dbReference type="Gramene" id="KVH89863">
        <property type="protein sequence ID" value="KVH89863"/>
        <property type="gene ID" value="Ccrd_008138"/>
    </dbReference>
    <dbReference type="OMA" id="NECIIAQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF46">
        <property type="entry name" value="CAROTENOID CLEAVAGE DIOXYGENASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="572" mass="63196" checksum="28C9EC5A1CDB6C4D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGG0</accession>
    <name>A0A103XGG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005107">
        <property type="protein sequence ID" value="KVH90305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGG0"/>
    <dbReference type="STRING" id="59895.A0A103XGG0"/>
    <dbReference type="Gramene" id="KVH90305">
        <property type="protein sequence ID" value="KVH90305"/>
        <property type="gene ID" value="Ccrd_007689"/>
    </dbReference>
    <dbReference type="OMA" id="ADCTRWS"/>
    <dbReference type="OrthoDB" id="1881997at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="286" mass="32205" checksum="AD6FCE96D4A8DC1B" modified="2016-04-13" version="1">MRTSNHLIGLLNFLTFLLSIPILAGGIWLSTRANNTDCMTFLQWPLIVIGVSIMVVSLAGIAGACYRNTFLMYLYLWAMFIIIAVLIGFIIFAYAVTDKGSGRPVMNRVYPDYYLQDYSGWLKDRVASDEYWGKIRSCIHDSKACAKTGRVIGGYPETADMYYLRKLNSIQSGCCKPPTDCGYIYVNETVWTPVNAATLASNLDCNRWSNDQEQLCYNCDSCKAGVLASLKKSWRKVSVINIVVLIILVIAYVIACAAFRNNKRIDNDEPYGATRMEKARPTRIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHN8</accession>
    <name>A0A103XHN8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHN8"/>
    <dbReference type="STRING" id="59895.A0A103XHN8"/>
    <dbReference type="Gramene" id="KVH90918">
        <property type="protein sequence ID" value="KVH90918"/>
        <property type="gene ID" value="Ccrd_007035"/>
    </dbReference>
    <dbReference type="OMA" id="GRFSITE"/>
    <dbReference type="OrthoDB" id="1908104at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47373">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47373:SF1">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018670315" evidence="3">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="4">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="13937" checksum="AB3A114F19CCFD7F" modified="2016-04-13" version="1">MSRSTILTFSLVIFFLFVSSCVVNGIPGGRTKIEDVKTNKEVQELGSYSVDEYNKLQRSQKGGAGDLKFSKVVSAESQVVSGIKYYLKIEAVSKSGVSKIFDAEVVVKPWMHSKQLLNFKPSPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI13</accession>
    <name>A0A103XI13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_006894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005079">
        <property type="protein sequence ID" value="KVH91100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI13"/>
    <dbReference type="STRING" id="59895.A0A103XI13"/>
    <dbReference type="Gramene" id="KVH91100">
        <property type="protein sequence ID" value="KVH91100"/>
        <property type="gene ID" value="Ccrd_006894"/>
    </dbReference>
    <dbReference type="OMA" id="EPTFWFS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF6">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="53"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="304"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH91100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="412" mass="44403" checksum="BE19E6D29990D8AE" modified="2016-04-13" version="1">MVSSSSRQGLRLSASMSADASSSGVDLHGKVSTDTFNQVSDYSMVSPSSNFNLGFSERAFSAAGAAFLSAIIVNPLDVAKTRLQAQAAGVAYQNLSHTCSFETNTMLPDRRCFPSCHRSVLGKPSCAPDSSQYKGTLDVFNKIIRQEGFGRLWRGTSASLALSVPTVGIYLPCYDIFRNFLEEFSSQNAPSMTPYVPLVAGSVARSLACITCYPVELARTRMQAFKDTLHAKKPPGVWKTLVGVVSTNRSTNNLRTLHSFRFLWTGLGAQLARDVPFSAICWATLEPVRRQLLAMSGDGTNPVTVLGANFFAGFVAGSLAGASTCPLDVAKTRHQIEKDQVRALKMTTRQTLVEIWSRDGGTKGLFMGVGARVGRAGPSVAIVVSFYEFVKYVLHTQKLTNTQTSTTGGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK30</accession>
    <name>A0A103XK30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004844">
        <property type="protein sequence ID" value="KVH92143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK30"/>
    <dbReference type="STRING" id="59895.A0A103XK30"/>
    <dbReference type="Gramene" id="KVH92143">
        <property type="protein sequence ID" value="KVH92143"/>
        <property type="gene ID" value="Ccrd_005829"/>
    </dbReference>
    <dbReference type="OMA" id="FIDEDLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328">
        <property type="entry name" value="FAR-RED IMPAIRED RESPONSIVE (FAR1) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328:SF42">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25318" checksum="05E9E951F15DB790" modified="2016-04-13" version="1">MEFEPLGIGSDVIEFDTMRLGDGAVNVEDDENKMFVDTQYEYGGRTMDSGYGGGEIFVSGGDTGLEPYEGMEFESEEAAKAFYNSYARRIGFSTRVSMSRRSRRDGAITQRSFVCAKEGFRADKEKSSCENGGGRVKRPRVETRVGCKAMMVVKIQGSGKWVVSGFVKDHNHELVPPDKVHCLRSHRHVSGSAKSLIDTLQRAGIGPSGIMRNSAVSLLSIRVLKVSSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMR3</accession>
    <name>A0A103XMR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004740">
        <property type="protein sequence ID" value="KVH93572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMR3"/>
    <dbReference type="STRING" id="59895.A0A103XMR3"/>
    <dbReference type="Gramene" id="KVH93572">
        <property type="protein sequence ID" value="KVH93572"/>
        <property type="gene ID" value="Ccrd_004377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="81" mass="8975" checksum="275770F9FCEEFE5E" modified="2016-04-13" version="1" fragment="single">MIDLLRYLLTKSSDEQSGLKDCSILNAINEHGVGQLKEYDLKKLVSTVKEGLELEDETGEGELGPFGSDKNDDGHYWGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMS4</accession>
    <name>A0A103XMS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004635">
        <property type="protein sequence ID" value="KVH93676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMS4"/>
    <dbReference type="Gramene" id="KVH93676">
        <property type="protein sequence ID" value="KVH93676"/>
        <property type="gene ID" value="Ccrd_004271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="17086" checksum="F8551CB61B30641E" modified="2016-04-13" version="1">MEDNEDFSTEFDVPPFPSPSDITFPSFIPPSEEETSKKRKRTTELSKMVEATKNSIDEATTQMKRLALVISDSTPEMDGLREELSGLGLGLIEIIQMGGHGRSNRRFWCPGEGDNEYRRKIARFNVLGEIKILFELEWMAGRPRFDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN59</accession>
    <name>A0A103XN59_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L34Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004712">
        <property type="protein sequence ID" value="KVH93614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN59"/>
    <dbReference type="STRING" id="59895.A0A103XN59"/>
    <dbReference type="Gramene" id="KVH93614">
        <property type="protein sequence ID" value="KVH93614"/>
        <property type="gene ID" value="Ccrd_004334"/>
    </dbReference>
    <dbReference type="OMA" id="FSYIFHS"/>
    <dbReference type="OrthoDB" id="1925408at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044196">
        <property type="entry name" value="At5g19025-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47479">
        <property type="entry name" value="OS05G0393200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47479:SF2">
        <property type="entry name" value="OS05G0393200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="234" mass="25948" checksum="B4D5836002B65059" modified="2016-04-13" version="1">MRHNLLSTSFIPMAPSSFSSTTTTHHHHHHHLNKKPSSSSSNPNPNTCTSCCSHHSPSATLDILILILVLFSGAFLVSSYFSYIFHSLSLILPPISLSILIDISSLYLIGFFLFFVLSIIGLEICCGNRSRKCGKKGCKGLKKAMEFDLQLQTEEILRSGAKGVKEMEELPWKGGSETNPDYECLRTELRKMAPMNGRAVLLFRSKCGCPVAKLEGWGPKRGRRNKKSLSLNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNH4</accession>
    <name>A0A103XNH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Harbinger transposase-derived nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNH4"/>
    <dbReference type="Gramene" id="KVH93992">
        <property type="protein sequence ID" value="KVH93992"/>
        <property type="gene ID" value="Ccrd_003955"/>
    </dbReference>
    <dbReference type="OMA" id="NECHSEE"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF272">
        <property type="entry name" value="HARBINGER TRANSPOSASE-DERIVED NUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="264"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="478" mass="53891" checksum="8B3F4E660B843D8C" modified="2016-04-13" version="1">MEISSIPFLNQEEYSYFYSFFQEFDTNNTAIDDIQTNKRRKINETTTGDSSSLKEILDTISFMDEQEIPDFDFQMPNLDFGSEMAEPERGRIRKTPPPKFDATVTEEWSSSQGGGGGGGGGGPQRRLWVKERSKGWWDYYNSDECPDEEFKKAFRMSKSTFNMICDELDAAVTKKDTMLRMAIPVRQRVAVCLYRLATGDPLRTVSSRFGLGISTCHKLVLEVCAAIRNVLMPKFLQWPDDERLEEIQTEFQSISGISNISGSIYTTHISIIAPKVTPAAYFNKKHTERNQKPSYSTTVQGVVDSRGVFTDICIGYPGSMSDDKILEKSAISQRFNIGYLKNIWIVGNSGYPLLDWLLVPYTHQHHTWSQHSFNEKIGDVQKTAKDAFMRLKGRWTCLQKRTEVKLQDLPVVLGACCVLHNICEMNGEAMDPDLSFDLFDDEIVVAENGGGKSGNAVQTRDTIAHNLLHCSNGGSGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRC0</accession>
    <name>A0A103XRC0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kunitz inhibitor ST1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004387">
        <property type="protein sequence ID" value="KVH95481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRC0"/>
    <dbReference type="STRING" id="59895.A0A103XRC0"/>
    <dbReference type="Gramene" id="KVH95481">
        <property type="protein sequence ID" value="KVH95481"/>
        <property type="gene ID" value="Ccrd_002451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011065">
        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002160">
        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF87">
        <property type="entry name" value="21 KDA SEED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00197">
        <property type="entry name" value="Kunitz_legume"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00452">
        <property type="entry name" value="STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50386">
        <property type="entry name" value="STI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="191" mass="21128" checksum="2DDC4196BBAA96A1" modified="2016-04-13" version="1">MPGPGAWQMKTSISSRWKKILFQKLNGESGGLFPANNSCPLGVAPTVDFHPQSTPKKGIIRLSTDVSIKFSSYNACNGSNVWKLVYDEDMKQFVVKVGGVEGNPGQKIVDNWFKMEKSGGEDGYKFVFCKKEKMTTYKGIPQINPLPCSFTGNPIGNSWSPYRHHYNASPCWLNASPELSVDVRADLSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSC6</accession>
    <name>A0A103XSC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chalcone/stilbene synthase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004365">
        <property type="protein sequence ID" value="KVH96005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSC6"/>
    <dbReference type="STRING" id="59895.A0A103XSC6"/>
    <dbReference type="Gramene" id="KVH96005">
        <property type="protein sequence ID" value="KVH96005"/>
        <property type="gene ID" value="Ccrd_001908"/>
    </dbReference>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000014">
        <property type="entry name" value="Chalcone synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000025">
        <property type="entry name" value="Chalcone synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF10">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="403" mass="43999" checksum="8046A7AAFDDBD354" modified="2016-04-13" version="1" fragment="single">MIQEEMTTKADGGKANILALGKAFPHQLVMQDLLVDGYFRDTNCDDPELRRKLTRLCKHPNIISDLVSFFTGKTTTVRTRYVVMSQEILEKYPELALEGLPTVKQRLDICNKAVTQMAIEASQACIKSWGRSVSDITHLVYVSSSEARLPGGDLYLAKGIGLSPDTNRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSVNRPYDLVGVALFGDGAGAMIIGSGPVSGLERPLFELHTAIQNFLPDTEKVIDGRLNEEGISFILARELPEIIEENVKGFCDKLLGHLGCDDMGYNDFFWAVHPGGPAILNKLEKKLDLWPEKLSASRRALADYGNASSNTIVYVLEYLIEESLMKKKEGKKGGPDLGLILAFGPGVTFEGILTRNLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT04</accession>
    <name>A0A103XT04_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SOFL plant protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004330">
        <property type="protein sequence ID" value="KVH96336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT04"/>
    <dbReference type="STRING" id="59895.A0A103XT04"/>
    <dbReference type="Gramene" id="KVH96336">
        <property type="protein sequence ID" value="KVH96336"/>
        <property type="gene ID" value="Ccrd_001579"/>
    </dbReference>
    <dbReference type="OMA" id="HETNNNH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044670">
        <property type="entry name" value="SOFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33347">
        <property type="entry name" value="OSJNBA0091C07.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33347:SF31">
        <property type="entry name" value="PROTEIN SOB FIVE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="15119" checksum="8D4BB0E3EE436A57" modified="2016-04-13" version="1">MEFSKYLGVAEGCSSSESGWTMYIVSPMHETNNNHHHHDVDDAIDEIHDGYHNGDSDDSMVSDASSGPSRQGILRGSSKRRSGLRRDQSKHAMNKDLIGKNQRQVEKLYERRQRAGKEEEYKNPNDNKARKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTC5</accession>
    <name>A0A103XTC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004283">
        <property type="protein sequence ID" value="KVH96496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTC5"/>
    <dbReference type="STRING" id="59895.A0A103XTC5"/>
    <dbReference type="Gramene" id="KVH96496">
        <property type="protein sequence ID" value="KVH96496"/>
        <property type="gene ID" value="Ccrd_001416"/>
    </dbReference>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="21952" checksum="CA4CC4481AEEB632" modified="2016-04-13" version="1">MKTILSSETMDIPEGVEIKVKAKVIEVKGPRGTLTRNFKHLNLDFQLITDEETGKQKLKVDAWFGSRKTTAAIRTALSHVNNLINGVTQGYRYKMRFVYAHFPINASITNGNTAIEIRNFLGEKKVRKVDMLDGVTVVRSEKVKDELILDGNDIELVSRSCALINQKCHVKNKDIRKFLDGIYVSDKAKIQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTK8</accession>
    <name>A0A103XTK8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004263">
        <property type="protein sequence ID" value="KVH96616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTK8"/>
    <dbReference type="STRING" id="59895.A0A103XTK8"/>
    <dbReference type="Gramene" id="KVH96616">
        <property type="protein sequence ID" value="KVH96616"/>
        <property type="gene ID" value="Ccrd_001292"/>
    </dbReference>
    <dbReference type="OMA" id="SNRYIAY"/>
    <dbReference type="OrthoDB" id="1500021at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF162">
        <property type="entry name" value="VESICLE-ASSOCIATED PROTEIN 1-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="204" mass="23888" checksum="8F9A9A7815E6B2A7" modified="2016-04-13" version="1">MDADFGEIEPEELKFLFKPKVQIMCIVKLINKSNRYIAYKVKTTRPKLYCVRPNIGIVKPDSTCEVHVTRQAQAILPVSSEIEKEKFLFERMFVPESMALEEVSSIFLSKDGDTDINKKKLKVVFDDTPMMEEMKSKNEERHLMLKKVEETILLRSKIKELDLRLVEAEETISKLKEQKTDDRDCSSRKTRSRVFIKCFNVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUM6</accession>
    <name>A0A103XUM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003850">
        <property type="protein sequence ID" value="KVH97191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUM6"/>
    <dbReference type="STRING" id="59895.A0A103XUM6"/>
    <dbReference type="Gramene" id="KVH97191">
        <property type="protein sequence ID" value="KVH97191"/>
        <property type="gene ID" value="Ccrd_000702"/>
    </dbReference>
    <dbReference type="OMA" id="TKRRMAH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="403" mass="45015" checksum="3CEA6C08F361F025" modified="2016-04-13" version="1">MKCFHYFKDKTRSRSQRSAPILKDETNFGISGDVSSGARVTQSTGSANSPRGIMELYEEKAGKLRVFKYTELRHATNDFTRLRKVGEGGFGCVYKGSIKPLDGNGDPIVGHKQWVAEVQFLGVVDHPNLVKLIGYCATDGERGIQRLLVYEFMPNKSLEDHLFTNSPQPLPWQRRLEIMFGAAQDFKTSNILLDENFNPKLSDFGLAREGPTEGNTHVSTAVMGTHGYAAPDYIETGHLTAKSDVWSFGIVLYEILTGRRSLERKRPKEDQKLLDWVRRYPIDGKKFGLIVDPRLGDQYSLTAARKIAKLADSCLLKSAKDRPKMSQVVESLKQILEVPTEGSPSSKSLEMVDDEPEDLTEKTKTTDGSESSKRRLAQLAKLSEHVGGVSKKGFMIMHRAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW03</accession>
    <name>A0A103XW03_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW03"/>
    <dbReference type="STRING" id="59895.A0A103XW03"/>
    <dbReference type="Gramene" id="KVH97846">
        <property type="protein sequence ID" value="KVH97846"/>
        <property type="gene ID" value="Ccrd_000061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="13652" checksum="59A84936D62B97E5" modified="2016-04-13" version="1">MELIQFLTFHCCLTISGDPNYINPLGVSRSPVLAYETCIIIQTNNGNVILRAEIKDGQYVFDIPTVACSIGIQTSAVSNQLQILKLKGEITYELKDPAYCYMIINFPKDICSLAADLAKWCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYB3</accession>
    <name>A0A103XYB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003637">
        <property type="protein sequence ID" value="KVH99089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYB3"/>
    <dbReference type="STRING" id="59895.A0A103XYB3"/>
    <dbReference type="Gramene" id="KVH99089">
        <property type="protein sequence ID" value="KVH99089"/>
        <property type="gene ID" value="Ccrd_022708"/>
    </dbReference>
    <dbReference type="OMA" id="QGYKANP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="91" mass="9885" checksum="99214F30882FA915" modified="2016-04-13" version="1">MPEYPVIDRNPPFTKTVANFNTLDYLRLTTISGISVTVGYLSGIKPGIRGPSMVTGGLIGVMGGFMYAYQNSAGRLMGFFPNDGEVARYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYT5</accession>
    <name>A0A103XYT5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Movement protein binding protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003622">
        <property type="protein sequence ID" value="KVH99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYT5"/>
    <dbReference type="STRING" id="59895.A0A103XYT5"/>
    <dbReference type="Gramene" id="KVH99300">
        <property type="protein sequence ID" value="KVH99300"/>
        <property type="gene ID" value="Ccrd_022462"/>
    </dbReference>
    <dbReference type="OMA" id="SMQADIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051224">
        <property type="term" value="P:negative regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010375">
        <property type="term" value="P:stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040289">
        <property type="entry name" value="MBP2C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35502">
        <property type="entry name" value="PROTEIN MICROTUBULE BINDING PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35502:SF2">
        <property type="entry name" value="PROTEIN MICROTUBULE BINDING PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35367" checksum="CFDCA402E4F8DA85" modified="2016-04-13" version="1">MYHQSSQHFDLEQDNATLGFGGGEPTSWLSGEDLRPSSPSHRRNLSAFSSSTATTAAGNVDRLLFNDLVQIVPLVQSLIDRKANTSYTRRGSMIYTKTPSRESLANKMTEAKGRNAQSIPGKKRRDNGGNEQDGGADGFSMFSSSSVLTKEREELAELREKVVDLERQLLEKDEILKSTEASKDKINSVNSMLDEIKLADKQAAVEKLQWEAMTSNRKAEKLQEDLNAIQGEMSSYKVLFEGLSSDNFNLSDQEYDVIPHVGHLPEIDDLDELDMSKMEEAKEAYMAAIAAAKEKQDEESITVAANARLHLQSFVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0F4</accession>
    <name>A0A103Y0F4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003396">
        <property type="protein sequence ID" value="KVI00217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0F4"/>
    <dbReference type="STRING" id="59895.A0A103Y0F4"/>
    <dbReference type="Gramene" id="KVI00217">
        <property type="protein sequence ID" value="KVI00217"/>
        <property type="gene ID" value="Ccrd_021552"/>
    </dbReference>
    <dbReference type="OMA" id="PPMPDDH"/>
    <dbReference type="OrthoDB" id="784725at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF15">
        <property type="entry name" value="EN_SPM-LIKE TRANSPOSON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119260" evidence="3">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="17230" checksum="269EDCAA33151205" modified="2016-04-13" version="1">MAINRLLPLFAFAFLSTIAVSSSYNPEFSPSPSPAPQLGSDDSPSVPESSPSPSIGLPPAPPPSDLSPSPSLDVFSPPSSSPAPSPSYFSAPSPSPSEASDISADVKNIDETMDSSPGGMSGGKKAGVAFGVIAAAFFVGFGGILYRKRQQNIRRAQYSYAARSDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y133</accession>
    <name>A0A103Y133_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003370">
        <property type="protein sequence ID" value="KVI00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y133"/>
    <dbReference type="Gramene" id="KVI00597">
        <property type="protein sequence ID" value="KVI00597"/>
        <property type="gene ID" value="Ccrd_021150"/>
    </dbReference>
    <dbReference type="OMA" id="CCAIARL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF452">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23239" checksum="40D0346EB03EFEEC" modified="2016-04-13" version="1">MHLCVIKYAYDNDPIVLSSLISMYSKCGFMNDANLVFDTTSRKDTVSWNAMIVANAYHGSAMKSLKLFFSMTKFGFKPNHLTFSGLLTGFAHSGMVHESWKLFNSMEKDWNVKPTTEHYAIMIDVLGRTGMLAEAYELVKQLPVELPVYTWETLLSCCRVHENFELGEVVALKLSGTRPLDVGMGVLQSNIYAARGMWKDVALERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1I3</accession>
    <name>A0A103Y1I3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003245">
        <property type="protein sequence ID" value="KVI00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1I3"/>
    <dbReference type="STRING" id="59895.A0A103Y1I3"/>
    <dbReference type="Gramene" id="KVI00803">
        <property type="protein sequence ID" value="KVI00803"/>
        <property type="gene ID" value="Ccrd_020940"/>
    </dbReference>
    <dbReference type="OMA" id="CNETKAA"/>
    <dbReference type="OrthoDB" id="511222at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36769">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-DEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36769:SF1">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-DEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="86" mass="9535" checksum="E436AB4FF69FC59E" modified="2016-04-13" version="1">MTQKANLFKGQQKRKTVPPSRHGKTPKTRKGKRVVKPAKVTQEMDTDRELSKFINYCNEVKAATAANKEGGQLSIVKHQAGEAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1R5</accession>
    <name>A0A103Y1R5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, SWIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003162">
        <property type="protein sequence ID" value="KVI00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1R5"/>
    <dbReference type="STRING" id="59895.A0A103Y1R5"/>
    <dbReference type="Gramene" id="KVI00940">
        <property type="protein sequence ID" value="KVI00940"/>
        <property type="gene ID" value="Ccrd_020799"/>
    </dbReference>
    <dbReference type="OMA" id="YHERRHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF2">
        <property type="entry name" value="OS09G0309100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="553"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="703" mass="81366" checksum="5880BE716463BBE9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2J9</accession>
    <name>A0A103Y2J9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003119">
        <property type="protein sequence ID" value="KVI01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2J9"/>
    <dbReference type="STRING" id="59895.A0A103Y2J9"/>
    <dbReference type="Gramene" id="KVI01342">
        <property type="protein sequence ID" value="KVI01342"/>
        <property type="gene ID" value="Ccrd_020405"/>
    </dbReference>
    <dbReference type="OMA" id="FILMNHN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF38">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="220" mass="24911" checksum="9EEC841AE05FEBE5" modified="2016-04-13" version="1">MELQLALSLSSSSSSHSQLDLNHYIHPPKPIQMEDHHHFKRRKKLSVNGHHVNDDDHDHDHDDDGGFHIIPQTLPLLFCNNPKYNQQLLHQDDDNDDDDDDDDVQSTFILMNHNMKRLCRQKNGGGDGGGGGGSDGDGRSKSMYVKVQMEGVGIARKIDLNLHYSYHTLTHTLAHMFGKCNEDVKLTYQDKEGDWLLAGDVPWGSFMKTVQRLKLLKSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2U7</accession>
    <name>A0A103Y2U7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003077">
        <property type="protein sequence ID" value="KVI01489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2U7"/>
    <dbReference type="STRING" id="59895.A0A103Y2U7"/>
    <dbReference type="Gramene" id="KVI01489">
        <property type="protein sequence ID" value="KVI01489"/>
        <property type="gene ID" value="Ccrd_020247"/>
    </dbReference>
    <dbReference type="OMA" id="MANSKQG"/>
    <dbReference type="OrthoDB" id="691484at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF94">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="26985" checksum="4C4B95B40D297D1D" modified="2016-04-13" version="1">MKLNLEGVGGGCRMSLMPSPETLMTNHGGVGDGGILGTVGATKFMRIIEEDCNSSGSSSIGNNSDDDDDREGDAESPYRYDHHNNNNNNKINNGSLDDALQALEEALPIRRGISTFYNGKSRSFTCLADVWPSSPPSIKDIAKPENAYTRKRRNLLASTLSSSKNKNRAFQLSNISIGRISKKSKTLTLQFASENEDHDVKTQPQFNKTSLLKKQNVSSMRSFSSMVNLHPCSSRFGLNSTEIRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3X0</accession>
    <name>A0A103Y3X0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin, Nup133/Nup155-like, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y3X0"/>
    <dbReference type="Gramene" id="KVI02059">
        <property type="protein sequence ID" value="KVI02059"/>
        <property type="gene ID" value="Ccrd_019644"/>
    </dbReference>
    <dbReference type="OMA" id="HKDWYPS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1302" mass="146351" checksum="E7FF115DC401446D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3Y1</accession>
    <name>A0A103Y3Y1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial Rho-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002666">
        <property type="protein sequence ID" value="KVI02019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3Y1"/>
    <dbReference type="STRING" id="59895.A0A103Y3Y1"/>
    <dbReference type="Gramene" id="KVI02019">
        <property type="protein sequence ID" value="KVI02019"/>
        <property type="gene ID" value="Ccrd_019699"/>
    </dbReference>
    <dbReference type="OMA" id="LGDYHIG"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000927">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="32175" checksum="EF64A0F02E854709" modified="2016-04-13" version="1">MAHLCRKLLRLKLKRTIIWRVAVLRRCAGSLWDQVLACWIGKPIQYRQILESGPTATVCHHFPSGEMGSSCGDGIVSGEMRTVSAVGDRNKDASDLVALKITLLGDNLIGKTSFLAKYIGKEKKHDDFPATEVKQMDKTLSVRGARISYSIWEVGGDAFSADDCGSTAAIRVACKDSVAILFMFDLTSRCTLNSVIGWYQQARKYNQTAIPVMVGSKFDDFIELPIDLQWTISSEARAYAKAINATLFFSSASYNINVNKIFKFVTAKLFNLPWNLERNLKVGEPIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8Y6</accession>
    <name>A0A103Y8Y6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001935">
        <property type="protein sequence ID" value="KVI04704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y8Y6"/>
    <dbReference type="Gramene" id="KVI04704">
        <property type="protein sequence ID" value="KVI04704"/>
        <property type="gene ID" value="Ccrd_016976"/>
    </dbReference>
    <dbReference type="OMA" id="PMAAIEV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950:SF49">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY C, POLYPEPTIDE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="502" mass="57400" checksum="49C177507D5528CD" modified="2016-04-13" version="1">MDITSFVRENNLXTPFFVVSTIFFLLLILKLAKPSSSKNLPPGPPRLPIIGNLHQVGDRPHVSTAKFAKEYGPLISLRLGKQILVVASSPEAAIEILKTKDRFLSSRVVPSAFQQPSLIPHSLIWSDCNQTWKSLRTLSRTELFSAKALESHSRLREQKLGHLLDFLHRKQGQVIKMEDVVFITLFNTLTSIIFSRDFLDLEDDSATRDGLNESIHKIIEYGGIIKDVGSFFPIFERFDLQGIRKGTMREYKKTFAYWEDIIEERRAHVNSSTWSSEHAQSFLDRMLENGYSNDQINQLVTELFVAGTNTTTSSVVWAMTEFIRHKEVMSKIAEEIKREINSEKITDSQLSKLPYLQASIKEAMRLHPPVPLLLPHXAXETCEVMNYTIPKNSKIFVNLWAMGRDPKIWDDPLSFNPERFIGSKLDFKGXDFELLPFGSGRRMCPXMPSGIKSVQLILASLIREFDLILPNDADPXKLDMSEKFGIAMKMEKPLKEMEEFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9H5</accession>
    <name>A0A103Y9H5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001892">
        <property type="protein sequence ID" value="KVI04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9H5"/>
    <dbReference type="Gramene" id="KVI04987">
        <property type="protein sequence ID" value="KVI04987"/>
        <property type="gene ID" value="Ccrd_016675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="50" mass="5598" checksum="BE09200123397C76" modified="2016-04-13" version="1">MCMIFVLDAEELDDQMMSVLPQLTRDRISLLSNLKMPEVSKSGVSCYGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAK8</accession>
    <name>A0A103YAK8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01001869">
        <property type="protein sequence ID" value="KVI05561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YAK8"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000122">
        <property type="entry name" value="probable methyltransferase PMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1119">
        <property type="entry name" value="METHYLTRANSFERASE PMT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI05561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="57061" checksum="F791F80DE4788015" modified="2016-04-13" version="1">MVTKGNSGDNRTRSSVTIFIVVGLCCFFYLLGAWQRSGFGKGDSIALEMTTKGGADCNILPNLNFETHHSGDAGIVDASGTKVKDFKPCSARYTDYTPCHDQKRAMTFPRHDMIYRERHCPPQEQKLKCLIPAPKGYVTPFSWPKSRDYVPFANAPYKALTVEKAIQNWIQYEGNVFRFPGGGTQFPQGADAYIDQLASVIPIANGTVRTALDTGCGVASWGAYLWKRNVITMSFAPRDNHEAQVQFALERGVPAIVGVLGSIKMPYPSKAFDMAHCSRCLIPWGSNDGKYMMEVDRVLRPGGFWVLSGPPINWRNNYKSWQRPKEDLEEEQRSIEXVXKLLCWEKXSESGETXIWQKKLNXEXCRATEDAPGVTYCSQDPDDVWYKNMEKCVTPTNSKAEDVEYKPFPERLNAIPPRIASGSIPGVSADKYMEDNRQWKKHVNAYKRINRIIASGRYRNIMDMNAGFGGFAAALDSPKLWVMNVVPTLAENTLGVIYERGLIGIYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB20</accession>
    <name>A0A103YB20_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB20"/>
    <dbReference type="STRING" id="59895.A0A103YB20"/>
    <dbReference type="Gramene" id="KVI05796">
        <property type="protein sequence ID" value="KVI05796"/>
        <property type="gene ID" value="Ccrd_015868"/>
    </dbReference>
    <dbReference type="OMA" id="GSNHRYA"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="32188" checksum="708A03C1587242F8" modified="2016-04-13" version="1">MGQGEEETRSPPDVEIQERGEIYFLYRPKVEKEEAHGSDDVQRMYIILSPHDSIQHQEATTQEVKHDPLLRLIVMGRKRLPDPTQKGTPFWGFVELVTTKIQDVKNALKGEEYDTKTRGHRHKPPARALGEGVYRILKHHIRPEDKKKMHTHLIYKLQFPAEDDDQNQPQEALNVEREASFLIQIKNPIINRDVKRKQATFPAHLQAQFGKLRFHAADPPEFLNYEGCEFLLISASDDIQQELGLELKLPNELDDSCSHLLNTFGELASTDALFRGIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCW7</accession>
    <name>A0A103YCW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRDP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001651">
        <property type="protein sequence ID" value="KVI06777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCW7"/>
    <dbReference type="STRING" id="59895.A0A103YCW7"/>
    <dbReference type="Gramene" id="KVI06777">
        <property type="protein sequence ID" value="KVI06777"/>
        <property type="gene ID" value="Ccrd_014867"/>
    </dbReference>
    <dbReference type="OMA" id="AVFRYKY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057458">
        <property type="entry name" value="GRDP_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF15">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25334">
        <property type="entry name" value="C2_GRDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRDP C2" evidence="1">
        <location>
            <begin position="314"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="380" mass="43995" checksum="AB777B9A87272E1E" modified="2016-04-13" version="1">MERLILGYGVWGIGYQRVSAGIGYRVSGIGYRVSGIGYQMVINIDLIAATKKHLQFLEAIDDNGKLYNGPLLERAVFRYKYCWLPLLAKHKDKVREWQLVVPLDCEWIWHCHRLNPVRYMADCKELFGRILDPSGMVKSSIEGTCKKETEKLWNKIYPKEPYEVGSGDRFDNDDGNKLIASESTKYDLVSAVKRQSSFYYQRYKGFLHLIRRNMEKKSNQFCVPTYDIDLIWHTHQLHPLSYCNDTMSLLGNILDHDDNDFDRTKGQKLDVGFTRTTKQWAQMFSSTYWRVGSMYTDMTPLNRLNDLAQSSGIMFVEGNNHFNIYNDTEEPQALIFHCEPHGDLLFELIDGSSKSCLISLSELDPRLASPKWLEFETGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD84</accession>
    <name>A0A103YD84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001539">
        <property type="protein sequence ID" value="KVI06949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD84"/>
    <dbReference type="STRING" id="59895.A0A103YD84"/>
    <dbReference type="Gramene" id="KVI06949">
        <property type="protein sequence ID" value="KVI06949"/>
        <property type="gene ID" value="Ccrd_014698"/>
    </dbReference>
    <dbReference type="OMA" id="VHTIIHQ"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="123" mass="14210" checksum="B6954EABFD015FD0" modified="2016-04-13" version="1">MARIKVHELRGKSKADLFAQLKDLKAELALLRVAKVTGGAPNKLSKIKVVRTSIAQVLTVISQTQKSMLREAYKKKKYLPLDLRPKKTRAIRRRLTKHQASLKTEREKKKDKYFPLRKYAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDV6</accession>
    <name>A0A103YDV6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDV6"/>
    <dbReference type="Gramene" id="KVI07279">
        <property type="protein sequence ID" value="KVI07279"/>
        <property type="gene ID" value="Ccrd_014291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="26713" checksum="B848790D25CE554B" modified="2016-04-13" version="1">MNLVDLQGDYCPKNLCVFPSCMDLLYDECTSIACGNASKKEAKISALLNFRTQPSLIFCFPALLITATTTVFLILLRRRILILLILRHQIIHITLRLRELHLVHSFSGVPMQESLAPKHGRELLANSLKHLLDRGRVSDESRRHLQPSWRDMHDSRWVLTTWSGELQSSETDVVKRLVIEHHTFIGVFDQLGSTTVSETFGDGKTENVSIIRSGYSSRIFEIKSVPIPDPVPPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDY9</accession>
    <name>A0A103YDY9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with CYCT1-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDY9"/>
    <dbReference type="STRING" id="59895.A0A103YDY9"/>
    <dbReference type="Gramene" id="KVI07327">
        <property type="protein sequence ID" value="KVI07327"/>
        <property type="gene ID" value="Ccrd_014285"/>
    </dbReference>
    <dbReference type="OMA" id="YTQGGQY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000273">
        <property type="entry name" value="Cyclin-dependent kinase C-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000272">
        <property type="entry name" value="Cyclin-dependent kinase C-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF560">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE C-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="504" mass="56027" checksum="6FF3D9CF592BAC17" modified="2016-04-13" version="1" fragment="single">MAGAAYGQLNLDESPSWGSRSVDCFEKLEQIGEGTYGQVYMARELKTGEIVALKKIRMDNEKEGFPITAIREIKILKKLQHENVIKLKEIVTSPGPEMDEHGKSGGHKYKGSIYMVFEYMDHDLTGLADRPGLRFTIPQIKCYMKQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKLADFGLARSYSSDHKGNLTNRVITLWYRPPELLLGATKYGPSVDMWSVGCIFAELLHGKPILTGKNEPEQLNKIFELCGSPDEINWPGVSRIPWYNKFKPSRQMKRRVREVFRHFDRNALELLEKMLTLDPSQRISAKDALDAEYFWTDPLPCDPKRYKRQQQRQNEEMAKRQKLQHPQQHARLPPVQQSGQAQAHSQHWAGHNNHPMGNTGQASLTTGGPSHHQYGKPRGPPGGPNRYPPGGNPSVGGYYPDRAGGQGGVGFSGGPYPPQPRAASASGPRGASGSYGVGPPNYSQNVQYGGGSGAAARGPNVAGNRNQPYSWQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE06</accession>
    <name>A0A103YE06_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="7">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE06"/>
    <dbReference type="STRING" id="59895.A0A103YE06"/>
    <dbReference type="Gramene" id="KVI07341">
        <property type="protein sequence ID" value="KVI07341"/>
        <property type="gene ID" value="Ccrd_014359"/>
    </dbReference>
    <dbReference type="OMA" id="KTWISIM"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000006">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000008">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000009">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009118">
        <property type="entry name" value="AnnexinD_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF104">
        <property type="entry name" value="ANNEXIN D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01814">
        <property type="entry name" value="ANNEXINPLANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609118-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="36119" checksum="351693606BAE26B2" modified="2016-04-13" version="1">MSTITVPAHAPSVTDDVEQLRKAFSGWGTNEGLLISILTHRNAEQRKQIREIYTSTYNEDLLKSLDKELSNDFERLVHLWTLDPAGRDAYLANEATKRWTRSNQVLMEIACTRSSHDLLLAKQAYHACYKKSMEEDVAYHTTGDFRKLLLLLVSSYRYEGSEVNMTLAKTEAKLLHEKICDKCYNDDDVIRILATRSKVQINATLNQYKNLFGNDIDKDLEGDSEDEFLALLRATIECLTYSEKYFEKVLRLAINKQGTDEGALTRVVATRAEVDLKIIKEEYERRNSVPLDRAIAKDTRGDYEDMLLSLLGCTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEY7</accession>
    <name>A0A103YEY7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001483">
        <property type="protein sequence ID" value="KVI07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEY7"/>
    <dbReference type="STRING" id="59895.A0A103YEY7"/>
    <dbReference type="Gramene" id="KVI07844">
        <property type="protein sequence ID" value="KVI07844"/>
        <property type="gene ID" value="Ccrd_013806"/>
    </dbReference>
    <dbReference type="OMA" id="FFCEGCF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="310"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="52601" checksum="430591DE87D9216F" modified="2016-04-13" version="1">MSGTMRNKVQRKCKMRGYTLKVEALNEILSFLSNYEDAEDEALDLLLDELQHQSLKSSILDKEPVQRVVSLLCEAGSAAEDNLSTSTTSSFSVIDAFLIPKFRYDPIRKMFCEHTGRLPIHGDAPAKAWLYRDRFLLLSQRLSRIPQFSSPSFNTELSEFGSCQISQIQSLVGRTGISWVMGVISQLEDGHFYLEDLTAAVEINLYKITTGYFSENTIVLAQGEMMLDGTFQVQTFGFPPLEDREKSASMFTGLDYFGGGTLPKEDTTMAKLETVLDGYEDVEVVPSLFVLMGNFCSHPFNLSYNSFSSPSTVLPRCALPKYITEELQKHIPNAIFASNPCRIKFYTQEIVFFRQDLLYRMRRSCLIPPSTEETSDPFEHLVATITHQSHLCPLPLSVQPIIWNYDHCLHLYPTPHTIVLGDNSEQKAFKYTDITCFNPGSFSNDSTFVVYRPCNREVELSALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF55</accession>
    <name>A0A103YF55_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_013689</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001457">
        <property type="protein sequence ID" value="KVI07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF55"/>
    <dbReference type="STRING" id="59895.A0A103YF55"/>
    <dbReference type="Gramene" id="KVI07945">
        <property type="protein sequence ID" value="KVI07945"/>
        <property type="gene ID" value="Ccrd_013689"/>
    </dbReference>
    <dbReference type="OMA" id="WNGYAEN"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12539">
        <property type="entry name" value="RRM_U2AF35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="183"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="36899" checksum="40DA5D69293FCC8F" modified="2016-04-13" version="1">MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHTKPSISPTLLLSNMYQRPDSITPGVDPQGQPLDPRKIQDHFEDFYEDLFEELSKYGEIESLNICDNLADHMVGNVYVQFREEEHAANALQNLSGRFYAGRPIIVDFSPVTDFREATCRQYEENVCNRGGYCNFMHLKKISRELRRQLFGRSRRRRSRSRSHSPQRHRGYDERPQGGGRGSGRRGGDYADQRHHDRGRRPRSRSPGRRGGRSRSPGGKRNRSPVREGSAERRAKIEQWNREREQADSRPKSATNDNNSDDGAVPNGDQYYDPRQQQHDDGGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFB0</accession>
    <name>A0A103YFB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA (Cytosine-5)-methyltransferase 1, replication foci domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001376">
        <property type="protein sequence ID" value="KVI08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFB0"/>
    <dbReference type="STRING" id="59895.A0A103YFB0"/>
    <dbReference type="Gramene" id="KVI08048">
        <property type="protein sequence ID" value="KVI08048"/>
        <property type="gene ID" value="Ccrd_013585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235:SF3">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RFTS" evidence="5">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="448" mass="51346" checksum="79FFF9958E9FC69A" modified="2016-04-13" version="1">MKTGRPNLAVQWSESESLDNNNSQICLRGTADNGLQKLYRPVKAWKCDISKAKPEISALSRDNNWIKLLKPRKCFEDLIRTILIIVYCLHFFKRKPEASGKSDIRPLENDLVDHLSFISEAMKRNKTLRKFEFLASLLEKKPRKRKDLDENTEVTMKPNFIVDDMNDECGDEELTIKAVKEYEFDDEDDGFETVCAICDDGGDLTCYEGKCLRPFHATIEYAEDHDVIFAQTALINNTSALFAGNWGLLINLLLQRVFAVVLQLVAIFITQSVLQRWFMRKVMLHHRNFKKKLLLVSHLHVMPTNAINVKRESMRSQIAFWNEDNDEDVIASVWNGLLPKARALQYFLKHKIDAELDTPLSNLKFLDIGHSKKQAVESLISKKEVADSDYTSKKGVGKFSSSVRPVDSSKKRVKMSYASEPMKRQRVTDNSKKLLQKNLSMIAGRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFW7</accession>
    <name>A0A103YFW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="12">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_013282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the interconversion of serine and glycine.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01001136">
        <property type="protein sequence ID" value="KVI08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFW7"/>
    <dbReference type="STRING" id="59895.A0A103YFW7"/>
    <dbReference type="Gramene" id="KVI08346">
        <property type="protein sequence ID" value="KVI08346"/>
        <property type="gene ID" value="Ccrd_013282"/>
    </dbReference>
    <dbReference type="OMA" id="FSATFEM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="13">
        <location>
            <begin position="12"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="461" mass="51101" checksum="13DAADF7B23052B8" modified="2016-04-13" version="1">MDPVNVWGNTALDAADPEIFDLIEKEKRRQCRGIELIASENFTSFAVIQALGSPLTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAYRLDPTKWGVNVQPYSGSPANFAAYTALLNPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSTTGFIDYEKMEEKALDFRPKLIICGGSAYPRDWDYKRIRSIADKCGALMLCDMAHISGLVAAQEAADPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQAEDAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQVMTPGFKSYAKQVRANAVALGNFLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITVNKNAVFGDSSTPAMTSRGLLEKDFEKIGEFLHRAIQITLSIQKEFGKLLKDFNKGLTNNKEIEELKADVEKFSGSFDMPGFSLADMKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH05</accession>
    <name>A0A103YH05_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_012703</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH05"/>
    <dbReference type="STRING" id="59895.A0A103YH05"/>
    <dbReference type="Gramene" id="KVI08918">
        <property type="protein sequence ID" value="KVI08918"/>
        <property type="gene ID" value="Ccrd_012703"/>
    </dbReference>
    <dbReference type="OMA" id="QICADEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000026">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF489">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114609" checksum="0FC6A7E1752CC540" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHC9</accession>
    <name>A0A103YHC9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHC9"/>
    <dbReference type="STRING" id="59895.A0A103YHC9"/>
    <dbReference type="Gramene" id="KVI09124">
        <property type="protein sequence ID" value="KVI09124"/>
        <property type="gene ID" value="Ccrd_012470"/>
    </dbReference>
    <dbReference type="OMA" id="NIEFDGA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000076">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387:SF52">
        <property type="entry name" value="RIBOSOMAL PROTEIN L9_RNASE H1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="169"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="313" mass="34469" checksum="4744B8DA4119CA01" modified="2016-04-13" version="1">MEDEKDAFYVVRKGDIVGVYKNFSDFQPLLYGPNVAVFKGYRLPKPAEEYLASHGLNNAIYSVGASDVQGELFGQLVPCPFQKPSKALATQVLDCWPVCKTLKKNTLGKKSSEDTLAMTYANEQPPSVKDKAGTKNPADNRIKKKVGSTSFSEGPQRKLPEIESFMETLPCSCILEFDGAAKGNPGPAGAGAVLRAIDGSLVYRLREGLGVATNNAAEYRAVILGLRYALERGFRHIRVQGDSKLVCMQVNGLWKTKTQNMTSLCKVAKELKDKFASFQICHVEREFNTEADAQANLGIHLQIGEVQEEVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIK2</accession>
    <name>A0A103YIK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar sorting protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIK2"/>
    <dbReference type="STRING" id="59895.A0A103YIK2"/>
    <dbReference type="Gramene" id="KVI09732">
        <property type="protein sequence ID" value="KVI09732"/>
        <property type="gene ID" value="Ccrd_011866"/>
    </dbReference>
    <dbReference type="OMA" id="FREYPYL"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000007">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="108"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="425" mass="47675" checksum="44362EEC9D7652E4" modified="2016-04-13" version="1">MENAEPFSSSTAPLTWHDFLERMRHPSASEFVKAIKSFIVSFSNNPPDPEKDSASVQEFLANMEAAFRAHPLWAGRSEEELDSAGEGLEKYIMTKLFTRVFATHPDDVKVDDQLYEKLALVQQFIRPENLDIQPTYQNETSWLLAQKELQKINIYKAPRDKLVCILSCCKVINNLLLNASVAANENPPGADEFLPVLIYVTIKANPPQLHSNLLYIQRYRRESRLVGEAAYFFTNMLSAEAFIMNIDGKALSMDEMEFQKNMESAQTLIYGLSGDYDGGESVSEPRQVKSHENSSVAVESTTDGANSKDQQQVNKIPSISDLENKGASTLMKEERGIEEFRKFPYLYSRTGDLTVGDVEELLNSYKQLVVKYVSLAKSIQSRNEGESLGKGKVDDVRIERGSDGVFTGDSESTEVVSRVEDTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK66</accession>
    <name>A0A103YK66_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001005">
        <property type="protein sequence ID" value="KVI10654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK66"/>
    <dbReference type="STRING" id="59895.A0A103YK66"/>
    <dbReference type="Gramene" id="KVI10654">
        <property type="protein sequence ID" value="KVI10654"/>
        <property type="gene ID" value="Ccrd_010942"/>
    </dbReference>
    <dbReference type="OMA" id="DVMVCGA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF297">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="38"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="42565" checksum="AFDA8BBBD6F48B26" modified="2016-04-13" version="1">MNRRWWCKSAQLCYRVHRSFSSSTVSHEPFKPPLFLPQRRVVVTGLGMVTPLGCGVETSWKRLIKGESGIRALSLEDLKMSGFDKDTQLYTFDQLTSKVAAIHGKSIARFISYALCAADEALRDANWIPSEQEEKEKTGVSIGGGIGSIGDILDASQLICEKGPNHAAVTACATGANSIGDAARMIQFGDADVMVAGGTEASIDALSIAGFCRSRALSTKNNSSPQEASRPFDCDRDGFVITPLTCFLMQHRRRCWRSCLGSDAHHITQPHADGRGAILAMSHALKQSGLCPDQVDYVTWWKPMQLNLCFLDMQHLGAIGHLLGAAGAVEAIFTVLAIHNGIAPLSLNLSNPDPIFEEDFMPLTASKEMQIRAALSNAFGFGGTNAALLFATMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKC6</accession>
    <name>A0A103YKC6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_010917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001004">
        <property type="protein sequence ID" value="KVI10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKC6"/>
    <dbReference type="STRING" id="59895.A0A103YKC6"/>
    <dbReference type="Gramene" id="KVI10679">
        <property type="protein sequence ID" value="KVI10679"/>
        <property type="gene ID" value="Ccrd_010917"/>
    </dbReference>
    <dbReference type="OMA" id="FRKTCAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="634" mass="70552" checksum="A2214B5924ED271B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL49</accession>
    <name>A0A103YL49_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000885">
        <property type="protein sequence ID" value="KVI11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL49"/>
    <dbReference type="Gramene" id="KVI11150">
        <property type="protein sequence ID" value="KVI11150"/>
        <property type="gene ID" value="Ccrd_010440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="38" mass="4285" checksum="A6FA4362D35B79FB" modified="2016-04-13" version="1" fragment="single">MGKKKALGTKMKSAINARIFTSITSSFFYFTITRDLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLD3</accession>
    <name>A0A103YLD3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000806">
        <property type="protein sequence ID" value="KVI11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLD3"/>
    <dbReference type="STRING" id="59895.A0A103YLD3"/>
    <dbReference type="Gramene" id="KVI11198">
        <property type="protein sequence ID" value="KVI11198"/>
        <property type="gene ID" value="Ccrd_010394"/>
    </dbReference>
    <dbReference type="OMA" id="QPFVGYN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF46">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="540" mass="57960" checksum="FEB662AE386180F3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLG1</accession>
    <name>A0A103YLG1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SF3A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000469">
        <property type="protein sequence ID" value="KVI11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLG1"/>
    <dbReference type="STRING" id="59895.A0A103YLG1"/>
    <dbReference type="Gramene" id="KVI11286">
        <property type="protein sequence ID" value="KVI11286"/>
        <property type="gene ID" value="Ccrd_010304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3A3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="13441" checksum="EE1FF45C3CFF9E9C" modified="2016-04-13" version="1">MESQTLVQIAVKLKNTFTRLKLGTTDQGENPNVGTTSLVVKPVLLRRKPMDLDMHELYNDYINSKFGKQIDYSSYLEVFSQPHTILQKLKLTREKAKSWKFILRLLLIYTSYIGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM17</accession>
    <name>A0A103YM17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000108">
        <property type="protein sequence ID" value="KVI11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM17"/>
    <dbReference type="STRING" id="59895.A0A103YM17"/>
    <dbReference type="Gramene" id="KVI11500">
        <property type="protein sequence ID" value="KVI11500"/>
        <property type="gene ID" value="Ccrd_010087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="192" mass="21702" checksum="549E81303560AB34" modified="2016-04-13" version="1">MKKLFFFKSSASSNRTSSLTSFQSKDKQLHSEKSLEETRKSRSKKAAYEDQSSLVLRKSRRIHLVKVLRSMRQLRLEDVVIGQYKGHSKGGKTNLRYTKDPTMPNDSLTPTFAAVALFIDNVWWDGVLFLTKAGKALNTRRHSRSLSGLTLRLFNSVIRKRTNAYVLAYGDGLSNPKSLQEDSEQGDSAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMI2</accession>
    <name>A0A103YMI2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_009844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000045">
        <property type="protein sequence ID" value="KVI11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMI2"/>
    <dbReference type="STRING" id="59895.A0A103YMI2"/>
    <dbReference type="Gramene" id="KVI11755">
        <property type="protein sequence ID" value="KVI11755"/>
        <property type="gene ID" value="Ccrd_009844"/>
    </dbReference>
    <dbReference type="OMA" id="LFNMFAA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="946" mass="108100" checksum="ECAF2F568DA1270A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNR5</accession>
    <name>A0A103YNR5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNR5"/>
    <dbReference type="STRING" id="59895.A0A103YNR5"/>
    <dbReference type="Gramene" id="KVI12428">
        <property type="protein sequence ID" value="KVI12428"/>
        <property type="gene ID" value="Ccrd_009087"/>
    </dbReference>
    <dbReference type="OMA" id="EYYTSIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="30967" checksum="DC786E64F61424CB" modified="2016-04-13" version="1" fragment="single">FQEYIRNSRGVQLFTCKWLPVSPPKALVFLCHGCGTKLASYGYAVFGIDYEGHGRSMGARCYIKKFDHIVADCSNYFKYISGQEDYKNKRRFLYGESMGGAVSLLISEKVKPHPMVISMLTRVEDVIPRWKIVPTKDVIDSAFKDPIKREEVRLIFAIGEFADTVTDPEVSRALYEQASSKDKTIKLYPGMWHGLTSGEPDQNIDIVFSDIISWLDKRCDDDYITDSSGAATVIDDIELVPSPMVEISKKKLRQSGSYLCGWKGRRMHHHSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRG8</accession>
    <name>A0A118JRG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family Ycf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006077">
        <property type="protein sequence ID" value="KVH87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRG8"/>
    <dbReference type="STRING" id="59895.A0A118JRG8"/>
    <dbReference type="Gramene" id="KVH87547">
        <property type="protein sequence ID" value="KVH87547"/>
        <property type="gene ID" value="Ccrd_025174"/>
    </dbReference>
    <dbReference type="OMA" id="HDRNIGR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056777">
        <property type="entry name" value="Ycf2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05695">
        <property type="entry name" value="Ycf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ycf2 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11793" checksum="CDB7334AEF375094" modified="2016-04-13" version="1">MVNLFKIITYLQNTISIHQIRDVKFFPKDEPDMDNSNKISFLNKNPFLIYFIYSMTGTEEDTQERFQEMVDVFTLPITASDLVYHKRIAFSIDSYGLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSH0</accession>
    <name>A0A118JSH0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005478">
        <property type="protein sequence ID" value="KVH88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSH0"/>
    <dbReference type="STRING" id="59895.A0A118JSH0"/>
    <dbReference type="Gramene" id="KVH88256">
        <property type="protein sequence ID" value="KVH88256"/>
        <property type="gene ID" value="Ccrd_024301"/>
    </dbReference>
    <dbReference type="OMA" id="PLGDRMF"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF95">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="213"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="46352" checksum="81AD495A82CDB8BA" modified="2016-04-13" version="1">MGNAQSPAGDPRFTSATRAFSEKELDDLKSLFGSLAAQSQSGGKYISLSAFKAYIGISGPLGDRLYDIVTQNRKDQKLTFEDLVIAKGTYEKGTKEEIDEFLYQLCDVDGDGNLTRSDLEAVISEILDNISSSRNYEPSSAPEQRPIGIFLDAANFTKDNEGSCGRSMSFEDFRSWCRFVPSARKFLISLLKPSSQGSQVPDLIHQDDIDSNMLLLKEYAWHIGGALSHQELEEWKLLYHSALHGQSFNTFLGNMSNAEGPTVLIIKDKEGYIYGGYASQPWERHADFYGDMKSFLFQLYPKASIYRPTGANKNIQWCGVNFSSDSIPNGIGFGGRTSHFNLFISSNFDHGHTFTGATFNSPCLSKSSQIYAEVIECWGIVAKGGQHEKQEGLKGSVLERFKEDRNMLNLVGLANSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT74</accession>
    <name>A0A118JT74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005244">
        <property type="protein sequence ID" value="KVH89322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT74"/>
    <dbReference type="Gramene" id="KVH89322">
        <property type="protein sequence ID" value="KVH89322"/>
        <property type="gene ID" value="Ccrd_008691"/>
    </dbReference>
    <dbReference type="OMA" id="IMEDSFL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009834">
        <property type="term" value="P:plant-type secondary cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="92"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="517" mass="59943" checksum="FD6E30F55102C1BA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTQ2</accession>
    <name>A0A118JTQ2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phytosulfokine</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="9">Phytosulfokine-alpha</fullName>
                <shortName evidence="9">PSK-alpha</shortName>
                <shortName evidence="9">Phytosulfokine-a</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Phytosulfokine-beta</fullName>
                <shortName evidence="9">PSK-beta</shortName>
                <shortName evidence="9">Phytosulfokine-b</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_007279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">PSK-alpha is produced by endopeptidase digestion. PSK-beta is produced from PSK-alpha by exopeptidase digestion.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Sulfation is important for activity and for the binding to a putative membrane receptor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phytosulfokine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTQ2"/>
    <dbReference type="STRING" id="59895.A0A118JTQ2"/>
    <dbReference type="Gramene" id="KVH90687">
        <property type="protein sequence ID" value="KVH90687"/>
        <property type="gene ID" value="Ccrd_007279"/>
    </dbReference>
    <dbReference type="OMA" id="MENCNEG"/>
    <dbReference type="OrthoDB" id="1914102at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009438">
        <property type="entry name" value="Phytosulfokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33285:SF33">
        <property type="entry name" value="PHYTOSULFOKINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33285">
        <property type="entry name" value="PHYTOSULFOKINES 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06404">
        <property type="entry name" value="PSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031592835" description="Phytosulfokine" evidence="9">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH90687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11320" checksum="756A259375D85E33" modified="2016-04-13" version="1">MKHSFHSGVPLIIILLSLLISFSHTSSARFLDTKPPGETTVKLDESINTSEGSLVDLQTINSFYEVMGMEECGSRDEECLKRRVLAEAHLDYIYTQHHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUQ6</accession>
    <name>A0A118JUQ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_005038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004802">
        <property type="protein sequence ID" value="KVH92902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUQ6"/>
    <dbReference type="STRING" id="59895.A0A118JUQ6"/>
    <dbReference type="Gramene" id="KVH92902">
        <property type="protein sequence ID" value="KVH92902"/>
        <property type="gene ID" value="Ccrd_005038"/>
    </dbReference>
    <dbReference type="OMA" id="RWPQSDY"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23145">
        <property type="entry name" value="RING-HC_SPL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044247">
        <property type="entry name" value="SPL2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH92902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="43299" checksum="AEE07FB7B62F409F" modified="2016-04-13" version="1">MSVHDQAAVAVLSQVALAADGAVLGLALAYIAVRSVLKYKTTSSALNKVKKAPSVGVSDLRSVLSHSSDQDTDTTSCVDEKLVIVRGVVEAKSVVNGNWKKQNVLVSHESNEKAVILQRTQTCIYNEWRGFFGWTSDFRSLFARHWKEQESSSLRTVPFILVDGGRWPQSDYLAVNLDGSKHPLPLTTVYHNLQPINASPYTFLQAFFGHEYPVGLLDEEKILPVGKEITAVGLVSLRNGIPEVMACKDLPFFLSNMSKDQMVVELDFRTKVLLWSGVVIGSLATAILGYSVVRNWNRWKEWRQRRQIQQQNAAEESSEAEADVAAEEGGDVPEGQLCVICLMRQRRSAFVPCGHLVCCPRCALSVERDLSPKCPVCRQTIRSSVRIYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVA1</accession>
    <name>A0A118JVA1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004607">
        <property type="protein sequence ID" value="KVH93744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVA1"/>
    <dbReference type="STRING" id="59895.A0A118JVA1"/>
    <dbReference type="Gramene" id="KVH93744">
        <property type="protein sequence ID" value="KVH93744"/>
        <property type="gene ID" value="Ccrd_004204"/>
    </dbReference>
    <dbReference type="OMA" id="TAWDCSA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03564">
        <property type="entry name" value="ANTH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000005">
        <property type="entry name" value="Clathrin assembly protein AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000006">
        <property type="entry name" value="putative clathrin assembly protein At5g35200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF32">
        <property type="entry name" value="OS06G0175500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="10">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="607" mass="67757" checksum="7D3B445E664DF4A4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWL1</accession>
    <name>A0A118JWL1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004379">
        <property type="protein sequence ID" value="KVH95679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWL1"/>
    <dbReference type="STRING" id="59895.A0A118JWL1"/>
    <dbReference type="Gramene" id="KVH95679">
        <property type="protein sequence ID" value="KVH95679"/>
        <property type="gene ID" value="Ccrd_002230"/>
    </dbReference>
    <dbReference type="OMA" id="WMERIKQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006514">
        <property type="entry name" value="IRX15/GXM/AGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01627">
        <property type="entry name" value="A_thal_3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31444">
        <property type="entry name" value="OS11G0490100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21729">
        <property type="entry name" value="IRX15_IRX15L_GXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14698" checksum="6F501B8B3B327C7D" modified="2016-04-13" version="1">MNTYRSEPECAPSKSYLRGNTRCKLALTGLPDVVYDKEWDIIMIDAPRGWFAEAPGRMGAIYSAAVMARNRKKGGVTHVFLHDVDRKVEKAYAEEFLCRKNLKDGAGRLWHFEIPAAAAAGNVTEGKGGTSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWW2</accession>
    <name>A0A118JWW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor IF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004480">
        <property type="protein sequence ID" value="KVH94974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWW2"/>
    <dbReference type="STRING" id="59895.A0A118JWW2"/>
    <dbReference type="Gramene" id="KVH94974">
        <property type="protein sequence ID" value="KVH94974"/>
        <property type="gene ID" value="Ccrd_002956"/>
    </dbReference>
    <dbReference type="OMA" id="MMSHENY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="104" mass="11581" checksum="0D8A212B3731A5B7" modified="2016-04-13" version="1">MLILEHYDDICRDRHRNLLVHPHTSIEDLDELSTLLQVPLVAGTVNRGSEVIAAGITVNDWTAFCGSDTTATELSVIESVFKLREAQPSAIVDEMRKSLIDTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY16</accession>
    <name>A0A118JY16_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003886">
        <property type="protein sequence ID" value="KVH97017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY16"/>
    <dbReference type="Gramene" id="KVH97017">
        <property type="protein sequence ID" value="KVH97017"/>
        <property type="gene ID" value="Ccrd_000888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="14996" checksum="0FAA1335C2B6D068" modified="2016-04-13" version="1">MVVFANLPQHSEGNVEYRGRGMLLWWMAYPASLIGVYQPSLHTQCFRFKRQKTWCLAEAYKVSRDRAPRSKWDIYFHFFDAQATKGNFEIVFNPFTHPNYFNVHIFLAEISQKRVGNRQLSSVKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYA8</accession>
    <name>A0A118JYA8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DELLA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The DELLA motif is required for its GA-induced degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GRAS family. DELLA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003822">
        <property type="protein sequence ID" value="KVH97662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYA8"/>
    <dbReference type="STRING" id="59895.A0A118JYA8"/>
    <dbReference type="Gramene" id="KVH97662">
        <property type="protein sequence ID" value="KVH97662"/>
        <property type="gene ID" value="Ccrd_000224"/>
    </dbReference>
    <dbReference type="OMA" id="PQNQIDH"/>
    <dbReference type="OrthoDB" id="761920at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1290:FF:000001">
        <property type="entry name" value="DELLA protein GAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1290">
        <property type="entry name" value="Transcriptional regulator DELLA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038088">
        <property type="entry name" value="DELLA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021914">
        <property type="entry name" value="TF_DELLA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12041">
        <property type="entry name" value="DELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01129">
        <property type="entry name" value="DELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Transcriptional factor DELLA N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="8">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="8">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="8">
        <location>
            <begin position="477"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="8">
        <location>
            <begin position="283"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LXXLL motif" evidence="8">
        <location>
            <begin position="381"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="555" mass="60330" checksum="A84CEBB60A3BB071" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZI8</accession>
    <name>A0A118JZI8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRAFD1/XAF1 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003651">
        <property type="protein sequence ID" value="KVH98830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZI8"/>
    <dbReference type="STRING" id="59895.A0A118JZI8"/>
    <dbReference type="Gramene" id="KVH98830">
        <property type="protein sequence ID" value="KVH98830"/>
        <property type="gene ID" value="Ccrd_022938"/>
    </dbReference>
    <dbReference type="OMA" id="HCGEMVA"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051986">
        <property type="entry name" value="Innate_Immune_Apopt_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295:SF10">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295">
        <property type="entry name" value="TRAF-TYPE ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TRAFD1/XAF1 zinc finger" evidence="6">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="198" mass="22368" checksum="DF0E4B4880AA85D6" modified="2016-04-13" version="1">MDVASDYATNICSHCDRAIPSSNIDLHYAHCSRNLEKCKICDDMIPKKHAEEHYLSTHAPVSCSLCSETMEPEILSLHKGEKCPQRIVTCDYCEFPLPAIDLFEHQEVCGNRTELCHLCNRYIRLRERTSHEVTCNGVPNNAAETSRGREGEREGGRRRPPPEDLSRKKLLFTIAITGIAVVLGSIIFHRKPVSSELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZM6</accession>
    <name>A0A118JZM6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZM6"/>
    <dbReference type="Gramene" id="KVI00135">
        <property type="protein sequence ID" value="KVI00135"/>
        <property type="gene ID" value="Ccrd_021583"/>
    </dbReference>
    <dbReference type="OMA" id="FKCNRDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF12">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="135"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="633" mass="70037" checksum="4079A3993CBFA99C" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZP4</accession>
    <name>A0A118JZP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003406">
        <property type="protein sequence ID" value="KVH99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZP4"/>
    <dbReference type="STRING" id="59895.A0A118JZP4"/>
    <dbReference type="Gramene" id="KVH99907">
        <property type="protein sequence ID" value="KVH99907"/>
        <property type="gene ID" value="Ccrd_021862"/>
    </dbReference>
    <dbReference type="OMA" id="FWNTQKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF70">
        <property type="entry name" value="ALPHA_BETA HYDROLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36214" checksum="CF18691D8CD34060" modified="2016-04-13" version="1">MKTTTMAAPTISAAAATSHTRKPNSDSSSRFPSGMLKKLLLVFFTGFLAWAYQSALAPPPKTVGSPDGLPVTSPRIKLRDGRHLSYKEYGVPKELAKYKIVFVHGFDSVKYYAALIEDLGIYIVSFDRPGYGESDPDPNRTLKSLALDIEELADQLGLGSKFYVFVQDQWTLRVAHYLPWLTYWWNTQKLFPSLTIIAHSPLVLSRQDRELIPKFTAGREAVQGQVRQQGEYESLHRDLNIGFGTWEFDPVEIENPFPNNEGSIHVWNGDEDLLVPVTLQRYVVQQLPWIRYHELKGAGHMFPYADGISDAILKTLLLGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0B7</accession>
    <name>A0A118K0B7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003123">
        <property type="protein sequence ID" value="KVI01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0B7"/>
    <dbReference type="STRING" id="59895.A0A118K0B7"/>
    <dbReference type="Gramene" id="KVI01247">
        <property type="protein sequence ID" value="KVI01247"/>
        <property type="gene ID" value="Ccrd_020488"/>
    </dbReference>
    <dbReference type="OMA" id="CDAECNG"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16358">
        <property type="entry name" value="GlxI_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036:SF5">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="98"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="205"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="36283" checksum="83283EF0A6B463D3" modified="2016-04-13" version="1">MVRIMPMASTIRPSLSSFATCRFAPGAISMVNSSSRFNSLHFASNVESQSQRFGLKACKLFRGEGNSKSVKTIVSMAQGSTATTQENALEWVKSDKRRMLHVVYRVGDMDRTIKFYTECLGMKLLRKRDIPEERYTNAFLGYGPEDSHFVIELTYNYGVDKYDIGSGFGHFGIAVDDAKGGTVTREPGPVKGGKSIIAFVEDPDGYKFELIERGPTPEPLCQVMLRAFGMELLRRRDNPEYKYTIAMMGYGPEDKSAVLELTYNYGIAIGTDDVYKTAEAVKLFGGKITREPGPLPGISTKITACLDPDGWKTVFVDNIDFLKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0U7</accession>
    <name>A0A118K0U7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family, basic secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002673">
        <property type="protein sequence ID" value="KVI01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0U7"/>
    <dbReference type="STRING" id="59895.A0A118K0U7"/>
    <dbReference type="Gramene" id="KVI01892">
        <property type="protein sequence ID" value="KVI01892"/>
        <property type="gene ID" value="Ccrd_019835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF15">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="10137" checksum="9A82DFB91B9F6C52" modified="2016-04-13" version="1">MATTNFIWSVIFQQNNPSDRKSVDSVNVYIEEFNEPIAFTWDNHNVNFSSIYIAGFSGDVKSFFLSVMYHEMTHVFHGMVRVLRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K161</accession>
    <name>A0A118K161_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agenet-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002655">
        <property type="protein sequence ID" value="KVI02338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K161"/>
    <dbReference type="STRING" id="59895.A0A118K161"/>
    <dbReference type="Gramene" id="KVI02338">
        <property type="protein sequence ID" value="KVI02338"/>
        <property type="gene ID" value="Ccrd_019382"/>
    </dbReference>
    <dbReference type="OMA" id="HAGYKWR"/>
    <dbReference type="OrthoDB" id="1883212at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20405">
        <property type="entry name" value="Tudor_Agenet_AtDUF_rpt1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917:SF101">
        <property type="entry name" value="OS07G0607300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="148"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="513" mass="59850" checksum="F5C07D6954A87AEC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2Q5</accession>
    <name>A0A118K2Q5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_016949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001930">
        <property type="protein sequence ID" value="KVI04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2Q5"/>
    <dbReference type="STRING" id="59895.A0A118K2Q5"/>
    <dbReference type="Gramene" id="KVI04727">
        <property type="protein sequence ID" value="KVI04727"/>
        <property type="gene ID" value="Ccrd_016949"/>
    </dbReference>
    <dbReference type="OMA" id="CMLHSRD"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000262">
        <property type="entry name" value="E3 ubiquitin-protein ligase XBAT33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056760">
        <property type="entry name" value="RING_XB3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24921">
        <property type="entry name" value="RING_XB3-XBAT31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="512" mass="54586" checksum="69EAE71A63F33A80" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3D4</accession>
    <name>A0A118K3D4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WLM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_015842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001861">
        <property type="protein sequence ID" value="KVI05808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3D4"/>
    <dbReference type="STRING" id="59895.A0A118K3D4"/>
    <dbReference type="Gramene" id="KVI05808">
        <property type="protein sequence ID" value="KVI05808"/>
        <property type="gene ID" value="Ccrd_015842"/>
    </dbReference>
    <dbReference type="OMA" id="LKDDIWC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI05808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="295" mass="33100" checksum="ABB53C7E998C7057" modified="2016-04-13" version="1">MNLNDLNKVWEVKPLKKPREDEAREILEKVARQVQPIMRKRKWKVKILSEFCPSNPALLGLNVNGGAEVKLRLRRQNNEWDFFPYEQILDTMLHELCHNEFGPHNSDFYNLLEEIRKECEELMAKGITGSGGGFDLPGRRLGGFSRQPPLSSLRQKALSAAENRVQRGTLLPSGPKRLGGDSSLRASLSPIQAAAMAAERRLHDDLWCASQVEEVGQTSVSQDVSSNEALPPILALALTCIACGTERMEEKKANTKTWSCKFCTLRNLAAKERCEACGEWRYSYGPPTTSRMLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3I7</accession>
    <name>A0A118K3I7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase, subunit Vb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI06015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3I7"/>
    <dbReference type="STRING" id="59895.A0A118K3I7"/>
    <dbReference type="Gramene" id="KVI06015">
        <property type="protein sequence ID" value="KVI06015"/>
        <property type="gene ID" value="Ccrd_015646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="106" mass="11542" checksum="CFEEDF871347183C" modified="2016-04-13" version="1">MWRRLPSQLQKFRSVQRSYGVTTLSPSPVTLQPCASLVSRHISSVSGNVSKKRVEDVMPIATGHEREELEAEIEEAPAVVKSYYDQRIVGCPGGEGGESTLPSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K412</accession>
    <name>A0A118K412_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-acyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01001616">
        <property type="protein sequence ID" value="KVI06795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K412"/>
    <dbReference type="STRING" id="59895.A0A118K412"/>
    <dbReference type="Gramene" id="KVI06795">
        <property type="protein sequence ID" value="KVI06795"/>
        <property type="gene ID" value="Ccrd_014851"/>
    </dbReference>
    <dbReference type="OMA" id="VIWPFLG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="24001" checksum="0455F1145454FD50" modified="2016-04-13" version="1">MKWRRFVSLPILAVLILMEMVYYGTVFIFLDDWIGLQSSAGWLNAVIFTSLASLTLFSFLVCVLTDPGGVPSGYFPDIENNDGSDQESRKAEALQKRCDKCSAYKPPRAHHCRVCRRCVLKMDHHCTWINNCVGQRNYKAFFLLVVYATISSFHSLVLIIGCGIQKDWEFARTTRLKTFYILGPSMLKWLCPTALSHVKDGTSFPTVRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K494</accession>
    <name>A0A118K494_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001510">
        <property type="protein sequence ID" value="KVI07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K494"/>
    <dbReference type="Gramene" id="KVI07203">
        <property type="protein sequence ID" value="KVI07203"/>
        <property type="gene ID" value="Ccrd_014441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="9319" checksum="614945860B67BDAC" modified="2016-04-13" version="1">MFIHSEYGPLPFRHKNCPTVAYGCMIHQLYFFRLHLDLCSLLDWVAKDLIRSGSDMTPDMQEETGDESKTRRLRLSDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4G0</accession>
    <name>A0A118K4G0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_014153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4G0"/>
    <dbReference type="STRING" id="59895.A0A118K4G0"/>
    <dbReference type="Gramene" id="KVI07470">
        <property type="protein sequence ID" value="KVI07470"/>
        <property type="gene ID" value="Ccrd_014153"/>
    </dbReference>
    <dbReference type="OMA" id="VPIDHNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="475" mass="54785" checksum="C1C7B5071F48A3BF" modified="2016-04-13" version="1" fragment="single">AKLHLPRTPFVAERPNKTTFVGRLCFSVHFIHRRSLRQRFRPPKSQPCKAHIIPKPSEEFRDKKFGIWTMDLDLWISKVKEGQHLSEDELQLLCEYVKDILIEESNVQPVNSPVTVCGDIHGQFHDLMKLFQTGGHVPETNYIFMVNLCCMHIILHIYCLRISLEDLRSCICILEVPCVSWQGDFVDRGYNSLEVFTILLLLKARCLSFLEMQEYPFCISYSIHCLTREFESNLCMPSCAANNGEVICGFYPSLLSFSVTYIFSCFTSACRYPANITLLRGNHESRQLTQVYGFYDECQRKYGNANAWRYCTDVFDYLTLSAIIDGTVLCVHGGLSPDIRTIDQIRVIERNCEIPHEGPFCDLMWSDPEDIETWAVSPRGAGWLFGSRVTSEFNHINKLDLVCRAHQLVQEGLKYMFQDKGLVTVWSAPNYCYRCGNVASILSFSETMEREVKFFTETEENNQMRGPRTGVPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4U4</accession>
    <name>A0A118K4U4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_013588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001376">
        <property type="protein sequence ID" value="KVI08055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4U4"/>
    <dbReference type="STRING" id="59895.A0A118K4U4"/>
    <dbReference type="Gramene" id="KVI08055">
        <property type="protein sequence ID" value="KVI08055"/>
        <property type="gene ID" value="Ccrd_013588"/>
    </dbReference>
    <dbReference type="OMA" id="YRITRYW"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000060">
        <property type="entry name" value="Putative strictosidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF106">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159970" description="Strictosidine synthase conserved region domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI08055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="391" mass="43852" checksum="2AB8AE5985D71686" modified="2016-04-13" version="1">MNIAGIFAGVFLLLAVYCGLDPFRHSAIVDFPDFESVKVEMPQWSEVPKDKDTQNLLRKSELKFLNQIQGPESVAFDSHGRGPYTGIADGRVVFWNGNSWSDFAYTSPNRSEICDPKPSILGYLKNEHICGRPLGLRFDKRTGDLYIADAYFGLLKVGPEGGLATSLVTEAEGVPLKFTNDLDIDGEGNIYFTDSSAKYQRRNFMHLVFSAEDSGRVLKYDPITKKTTVLLRNLQFPNGVSLSKDGSFFVFCEGSKGRLVKYWLKGEKAGTSEVMAILPGFPDNVRTNENGEFWVAIHARRSMYTYVCALYPKLRTFMLRLPIPARMQYLLNIGGQLHAMVVKYSPDGKILQILEDAQGKVVRAVSEVEERDGKLWMGSVLMSFIAVYELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4W6</accession>
    <name>A0A118K4W6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001227">
        <property type="protein sequence ID" value="KVI08160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4W6"/>
    <dbReference type="STRING" id="59895.A0A118K4W6"/>
    <dbReference type="Gramene" id="KVI08160">
        <property type="protein sequence ID" value="KVI08160"/>
        <property type="gene ID" value="Ccrd_013473"/>
    </dbReference>
    <dbReference type="OMA" id="KWEITKF"/>
    <dbReference type="OrthoDB" id="1856215at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328:SF9">
        <property type="entry name" value="FAR-RED IMPAIRED RESPONSIVE (FAR1) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328">
        <property type="entry name" value="FAR-RED IMPAIRED RESPONSIVE (FAR1) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="2">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="28929" checksum="B640D26480C84D20" modified="2016-04-13" version="1">MDFEVDDDVNGEVLVNSADVEGRTVDDDGTVGCSVVGIFQDDHDIKIDQDELERGIDPLDEPHAVNGSLLGAEPYLGQEFESEAAAHAFYNAYATRVGFVIRVSKLSRSRRDGTAIGRALVCNKEGFRMPDKREKVVRQRAETRVGCRAMILVRKVSSGKWEITKFVKEHTHPLTPGKGRRDLIYDQYPNEHDKIRELSQQLAIEKRRAATYKRHLEMVFEHIEEHNQSLSKKIKDIVNSVKEMESNELLQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5V5</accession>
    <name>A0A118K5V5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-type beta propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_011939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001049">
        <property type="protein sequence ID" value="KVI09678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5V5"/>
    <dbReference type="STRING" id="59895.A0A118K5V5"/>
    <dbReference type="Gramene" id="KVI09678">
        <property type="protein sequence ID" value="KVI09678"/>
        <property type="gene ID" value="Ccrd_011939"/>
    </dbReference>
    <dbReference type="OMA" id="TQGAHIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056819">
        <property type="entry name" value="ACBP4-6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF5">
        <property type="entry name" value="OS02G0822800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24922">
        <property type="entry name" value="ACBP4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Acyl-CoA-binding" evidence="4">
        <location>
            <begin position="393"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="530" mass="58299" checksum="AB6BF93DC0DC56FC" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K768</accession>
    <name>A0A118K768_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubber elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REF/SRPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000041">
        <property type="protein sequence ID" value="KVI11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K768"/>
    <dbReference type="STRING" id="59895.A0A118K768"/>
    <dbReference type="Gramene" id="KVI11792">
        <property type="protein sequence ID" value="KVI11792"/>
        <property type="gene ID" value="Ccrd_009793"/>
    </dbReference>
    <dbReference type="OMA" id="SEKYNVM"/>
    <dbReference type="OrthoDB" id="1905464at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008802">
        <property type="entry name" value="REF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33732">
        <property type="entry name" value="REF/SRPP-LIKE PROTEIN OS05G0151300/LOC_OS05G05940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33732:SF9">
        <property type="entry name" value="REF_SRPP-LIKE PROTEIN OS05G0151300_LOC_OS05G05940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05755">
        <property type="entry name" value="REF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="237" mass="25588" checksum="9C6D481975133451" modified="2016-04-13" version="1">MAENDGAVTTEREVVQSEEETLKYLQFVQVALLHAVLYASRVYGFAKQNSGPLKPGVETIEGALKTVVAPAYDKFHGVPVEVLKFVDRKVDESVTKFDGRVPPFVKQVSTKTKSLSNSGVVETASGLAKSAYTKLEPTAKGLYTKYEPVAEQYAASAWHSLNQLPLFPKVAKVVVPTAAYCSGKYNQTVQQTAEKGYKVSSYLPLVPTERIAKVFNSAEPQSEAVAPSGGDAAMVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RAX7</accession>
    <name>A0A124RAX7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007825">
        <property type="protein sequence ID" value="KVG65975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RAX7"/>
    <dbReference type="STRING" id="59895.A0A124RAX7"/>
    <dbReference type="Gramene" id="KVG65975">
        <property type="protein sequence ID" value="KVG65975"/>
        <property type="gene ID" value="Ccrd_026281"/>
    </dbReference>
    <dbReference type="OMA" id="ERVEYCY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025525">
        <property type="entry name" value="hAT-like_transposase_RNase-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF189">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN RICESLEEPER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14372">
        <property type="entry name" value="hAT-like_RNase-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="hAT-like transposase RNase-H fold" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG65975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="28006" checksum="FAA26D0E47CFC53F" modified="2016-04-13" version="1">MSSMPKDMQEKFDKYWSDYNILLSCAAILDPCFKLERVEYCYEKLYGETYAKEMVSRIKVTLFDLFDEYKRVACGATSPTFASSFGMTNVSHDVGCDENQMDDILEYKMFLSKTRKVENDKSELDLYLEEKNFDVMGKCDVLEYWNRSLYGKKLINPWRASLEEKIIEMLACYEDWLRAKGLTLGSTSLFNYDDSIVGEEDEDENEVEEDSFILEQKLLSGGCFTVKELWMFLIKNWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB60</accession>
    <name>A0A124SB60_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005195">
        <property type="protein sequence ID" value="KVH89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB60"/>
    <dbReference type="STRING" id="59895.A0A124SB60"/>
    <dbReference type="Gramene" id="KVH89621">
        <property type="protein sequence ID" value="KVH89621"/>
        <property type="gene ID" value="Ccrd_008397"/>
    </dbReference>
    <dbReference type="OMA" id="ITIQNWY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="406"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1158" mass="133543" checksum="B9B28BF5929851E1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD93</accession>
    <name>A0A124SD93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_001677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium sensor.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004344">
        <property type="protein sequence ID" value="KVH96237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD93"/>
    <dbReference type="STRING" id="59895.A0A124SD93"/>
    <dbReference type="Gramene" id="KVH96237">
        <property type="protein sequence ID" value="KVH96237"/>
        <property type="gene ID" value="Ccrd_001677"/>
    </dbReference>
    <dbReference type="OMA" id="FKKMMAP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000089">
        <property type="entry name" value="calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH96237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="13980" checksum="0C57BE2625387B89" modified="2016-04-13" version="1">MATETIKPSVHLTNIDEVEKVMTTIDTDCDGFINLEEFAGFCKGNADEQDGGIKELEEAFQLYDLNKNGLISSTELHQILTRLGERCTVDDCVTMIKSVDSDGDGFVNFEEFKKMMSNNSSNGDAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDF0</accession>
    <name>A0A124SDF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004223">
        <property type="protein sequence ID" value="KVH96745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDF0"/>
    <dbReference type="STRING" id="59895.A0A124SDF0"/>
    <dbReference type="Gramene" id="KVH96745">
        <property type="protein sequence ID" value="KVH96745"/>
        <property type="gene ID" value="Ccrd_001165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF113">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="15623" checksum="40957BAEB72CCF31" modified="2016-04-13" version="1">MLFCEKETENAADCCRAVAVPPCCLLLLFYGSTPDLTHYQNGDVIDSNKVAQILATFRSQVNKRRYESCDFNRKDYCLIVFRTLRKLYNVDPNDYMFSIYGMRIFRSSLLPEKWKLFLHVNDDRLITKTMKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDH1</accession>
    <name>A0A124SDH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_000985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004076">
        <property type="protein sequence ID" value="KVH96922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDH1"/>
    <dbReference type="Gramene" id="KVH96922">
        <property type="protein sequence ID" value="KVH96922"/>
        <property type="gene ID" value="Ccrd_000985"/>
    </dbReference>
    <dbReference type="OMA" id="DISSNCC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044818">
        <property type="entry name" value="ILR3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133:SF22">
        <property type="entry name" value="MYC-TYPE, BASIC HELIX-LOOP-HELIX (BHLH) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="201" mass="22310" checksum="899056CA24437D7C" modified="2016-04-13" version="1">MMVAPDEDDNSNCFFDFSLIEQIPVPGGELPSLESDFHWSSNPFHGPSNLSSAGFLDSAGTPDCSKELGSRKRFQELNEILDPGRPPKTDKMVILGDAIRRVTQLRDEAAEKNELRDEKQKLKAEKERLEQQVKAFSRPPATAAFYPPPPHSAMPIPFPPRPIVDSKFLPVMGYHGVPMWPFASATAVDTSEDHVLRSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDJ7</accession>
    <name>A0A124SDJ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003851">
        <property type="protein sequence ID" value="KVH97180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDJ7"/>
    <dbReference type="STRING" id="59895.A0A124SDJ7"/>
    <dbReference type="Gramene" id="KVH97180">
        <property type="protein sequence ID" value="KVH97180"/>
        <property type="gene ID" value="Ccrd_000723"/>
    </dbReference>
    <dbReference type="OMA" id="FQMDTLT"/>
    <dbReference type="OrthoDB" id="1716703at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF250">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP2-EREBP FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="329" mass="37403" checksum="A338E26076F7767F" modified="2016-04-13" version="1">MFTLQTLSSFEYPGLENSRAHLNDSSYMKMFPMLNQDDHDHDHDHSQEKSHEPLFCSRFLDGNQADEGGKKKKRPSPEREIQEVEWRRYRGVRRRPWGKFTAEIRNPEKKKARLWLGTFDTPEQAALAYDRAAFKFHGSRAKVNFPLLIGCDDRSVVLTPMQKMTHELHHPSSSMSSSSSSMENGQQRKNCMVDHPTTTATKVGSEHDSLHDLHLYTSTPYDFSLKNSMEAPATTITTGNMEEGRKDNDTLWSIFFQSTVQSPTATVTSGVDEVGGGDHDSMWDFQMLPVVEPPSATTTAVRASDVGTDHDPFWDFQMDTLTDDDFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE02</accession>
    <name>A0A124SE02_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003792">
        <property type="protein sequence ID" value="KVH98531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE02"/>
    <dbReference type="STRING" id="59895.A0A124SE02"/>
    <dbReference type="Gramene" id="KVH98531">
        <property type="protein sequence ID" value="KVH98531"/>
        <property type="gene ID" value="Ccrd_023240"/>
    </dbReference>
    <dbReference type="OMA" id="THVAHEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33474:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176185" evidence="1">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="9657" checksum="C6636BA1FDBF6F67" modified="2016-04-13" version="1">MFKAMALSTRFLVFILGFSLLVSTFDAIPISRIRNLISEEHSPDVSGNIHSGSLEDSWDESIVSRRMDLTTNDYQGSGANDRHTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE93</accession>
    <name>A0A124SE93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003574">
        <property type="protein sequence ID" value="KVH99387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE93"/>
    <dbReference type="Gramene" id="KVH99387">
        <property type="protein sequence ID" value="KVH99387"/>
        <property type="gene ID" value="Ccrd_022382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="65" mass="7545" checksum="DF966245C30118E6" modified="2016-04-13" version="1" fragment="single">MMKHDSRSCHAILKSHTIQSILWSDSKLFRTDLKQFSAILWRFSKATTFGGSNIDPTAWEEKKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEY2</accession>
    <name>A0A124SEY2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003063">
        <property type="protein sequence ID" value="KVI01513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI01513">
        <property type="protein sequence ID" value="KVI01513"/>
        <property type="gene ID" value="Ccrd_020215"/>
    </dbReference>
    <dbReference type="OMA" id="CYTTIAS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14371">
        <property type="entry name" value="CUE_CID7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001086">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g33170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001139">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041806">
        <property type="entry name" value="CID5/6/7_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF543">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Smr" evidence="4">
        <location>
            <begin position="491"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="965"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="1238"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI01513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1577" mass="175627" checksum="C64C8D5D66ED5300" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFG8</accession>
    <name>A0A124SFG8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002413">
        <property type="protein sequence ID" value="KVI03211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFG8"/>
    <dbReference type="STRING" id="59895.A0A124SFG8"/>
    <dbReference type="Gramene" id="KVI03211">
        <property type="protein sequence ID" value="KVI03211"/>
        <property type="gene ID" value="Ccrd_018493"/>
    </dbReference>
    <dbReference type="OMA" id="ITACELY"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009904">
        <property type="term" value="P:chloroplast accumulation movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009903">
        <property type="term" value="P:chloroplast avoidance movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031022">
        <property type="term" value="P:nuclear migration along microfilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000058">
        <property type="entry name" value="kinesin-like protein KIN-14B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF22">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-14A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="137"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1269" mass="140290" checksum="1DFECD6842F52E04" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGM3</accession>
    <name>A0A124SGM3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 8">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 8"/>
    <dbReference type="EMBL" id="LEKV01001597">
        <property type="protein sequence ID" value="KVI06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGM3"/>
    <dbReference type="STRING" id="59895.A0A124SGM3"/>
    <dbReference type="Gramene" id="KVI06811">
        <property type="protein sequence ID" value="KVI06811"/>
        <property type="gene ID" value="Ccrd_014834"/>
    </dbReference>
    <dbReference type="OMA" id="HALWRRY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000021">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="641" mass="69401" checksum="DC4FAAF17A205592" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SIA5</accession>
    <name>A0A124SIA5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000016">
        <property type="protein sequence ID" value="KVI12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SIA5"/>
    <dbReference type="STRING" id="59895.A0A124SIA5"/>
    <dbReference type="Gramene" id="KVI12076">
        <property type="protein sequence ID" value="KVI12076"/>
        <property type="gene ID" value="Ccrd_009510"/>
    </dbReference>
    <dbReference type="OMA" id="DYMNMVI"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="252" mass="29063" checksum="2B792C62C76AA83A" modified="2016-04-13" version="1">MAEEEDDYMGDLSQFLPSQSELSLNPPAPKVPSVNGGSKAANSQYSKKRPKIRNWQEQRKLKREIKQVEEDNRTLAGLESAIPQSNIGFKMLKQMGYTPGSGLGGSGRAEPVGLEIRRSRAGIGREDPIKEKLRKEEEMLWEKRRREEELMSDFGCRVKERWRNKRVVVNFHKAKGVLDQLENKEVVEVEKKDDDEKEEGEDEEEEVITEEDLHEILMKLRDDFQYCLFCGCQYESREALLGDCPGIDEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBF0</accession>
    <name>A0A103XBF0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005992">
        <property type="protein sequence ID" value="KVH87634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBF0"/>
    <dbReference type="STRING" id="59895.A0A103XBF0"/>
    <dbReference type="Gramene" id="KVH87634">
        <property type="protein sequence ID" value="KVH87634"/>
        <property type="gene ID" value="Ccrd_025081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="12711" checksum="295212AF99061E48" modified="2016-04-13" version="1">MTTASAHCSLGVNARFHENSRHFPSKLEFSSVNFHSDGEFFKISFNSSSASSIFFKGCVGRICALPEVGDGFSEKLPTPILDTIESPMHLKNLSHKVYAFLYPLYSLEISSSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XC74</accession>
    <name>A0A103XC74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005610">
        <property type="protein sequence ID" value="KVH88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XC74"/>
    <dbReference type="Gramene" id="KVH88043">
        <property type="protein sequence ID" value="KVH88043"/>
        <property type="gene ID" value="Ccrd_024572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040321">
        <property type="entry name" value="SCD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762">
        <property type="entry name" value="FAS-BINDING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762:SF11">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32738" checksum="F7C63258093CD3A9" modified="2016-04-13" version="1">MDQRRTASPVYPRKWSSESSTIAPASSSPARYHHSPRNSVEESQPPLSTPLTGRSSKSNSMLPLVPPSKTSLRTPMTIPPIDPPTKKQKDKRFQLEIGEINLKSTGDGREASALHDELDMLQEENENVLEKLRFAEESCQDAETRVKELEKQAALKEXKKAKDGVNEEVVSLRSEVKKAKDEATVVMDQLQGIESEVKALHSMTQRMVLTQSEMEEVVLKRCWLARYWGLAVFALILQCLSMSTGHLWHPFPSKLWFQPGRRQRKNAGNKASNCSLALTENSQYWVLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCU1</accession>
    <name>A0A103XCU1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005448">
        <property type="protein sequence ID" value="KVH88334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCU1"/>
    <dbReference type="STRING" id="59895.A0A103XCU1"/>
    <dbReference type="Gramene" id="KVH88334">
        <property type="protein sequence ID" value="KVH88334"/>
        <property type="gene ID" value="Ccrd_024120"/>
    </dbReference>
    <dbReference type="OMA" id="MPLRNQN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="459"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="135"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="543"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH88334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="744" mass="83718" checksum="48F886A3FA34581E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDA8</accession>
    <name>A0A103XDA8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_026239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005358">
        <property type="protein sequence ID" value="KVH88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDA8"/>
    <dbReference type="STRING" id="59895.A0A103XDA8"/>
    <dbReference type="Gramene" id="KVH88637">
        <property type="protein sequence ID" value="KVH88637"/>
        <property type="gene ID" value="Ccrd_026239"/>
    </dbReference>
    <dbReference type="OMA" id="AMVYEIM"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010075">
        <property type="term" value="P:regulation of meristem growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="112"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="372" mass="40423" checksum="BAD7D20826BCBF57" modified="2016-04-13" version="1">MTTRIAPGVGANLLGQHSAERNQDATAYVGNLDPQATEELLWELFVQAGPVVNVYVPKDRVTNLHQGYGFVEFRSEEDADYAIKVLNMIKLYGKPIRVNKASQDKKSLDVGANLFVGNLDPDVDEKLLYDTFSAFGVIVTNPKIMRDPETGNSRGFGFISYDSFEASDAAIESMNGQYLCNRQITVSYAYKKDTKGERHGTPAERTLASSNPSTQKSRPHTMFASGPPTLPKVGQPNGAPVPPRPFANGVVPPVPTIPAIRPPPPPAHVYQPMQMSVPPPQWQQMGQPQGMPPQHLQQFRPPPPSMPPPPSNMPQMMNRPPPPPAGMAGQHVWRAPPPPQQLTGGHGHPSMMQMSMPPPPPPNAPPPPPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFI0</accession>
    <name>A0A103XFI0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_008230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005142">
        <property type="protein sequence ID" value="KVH89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFI0"/>
    <dbReference type="STRING" id="59895.A0A103XFI0"/>
    <dbReference type="Gramene" id="KVH89776">
        <property type="protein sequence ID" value="KVH89776"/>
        <property type="gene ID" value="Ccrd_008230"/>
    </dbReference>
    <dbReference type="OMA" id="YVESSIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000191">
        <property type="entry name" value="Membrane H(+)-ATPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="722" mass="79596" checksum="D3D98FB06FDED837" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH59</accession>
    <name>A0A103XH59_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Digalactosyldiacylglycerol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_007398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005098">
        <property type="protein sequence ID" value="KVH90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH59"/>
    <dbReference type="STRING" id="59895.A0A103XH59"/>
    <dbReference type="Gramene" id="KVH90629">
        <property type="protein sequence ID" value="KVH90629"/>
        <property type="gene ID" value="Ccrd_007398"/>
    </dbReference>
    <dbReference type="OMA" id="MKHRANE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046481">
        <property type="term" value="F:digalactosyldiacylglycerol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019375">
        <property type="term" value="P:galactolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01635">
        <property type="entry name" value="Glycosyltransferase_GTB-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044525">
        <property type="entry name" value="DGDG1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132:SF6">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH90629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="87036" checksum="362CBA4D36D4CE4F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHZ0</accession>
    <name>A0A103XHZ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005080">
        <property type="protein sequence ID" value="KVH91078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016138">
        <property type="term" value="P:glycoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF51">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118821" evidence="4">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="441" mass="49046" checksum="A357A004704A2CCC" modified="2016-04-13" version="1">MSQGHTIPLLHLSGILFHRCISITIITTPANYSAVRATVTDGSISVIDIPFPGAPPGVEVSGKLPSMSSLIDFVKSTEKLQPGFEEVVRSLPPVTCIISDGXFSWXQDSADKLGIPRLVFYGINIFSMTMDHIMTQFKPHAAVNSDDERFQVPDFPRLKLTVNDFQPPFNEVDPKGPLHDFHVKQQAANAKSHGMVVNSFYELEPEFIDYWNQRVGPKAWCVGPFCIAKPKQKLVENQKPTWVQWLDEKLQPELYVSFGTMAETSPEQXREVAVGLEXSNVNFMWILXWKQLEXIGGAGFEERVKGRGKVVTEWXDXVEVLNHQSVGGFLSHCGWNSILESLSAGVAVLAMPLMADQHLXARMVVEEIGMGLRLWAREKVARGLVGAEEVEKMVVELMEGDGGRRVRERXAKVKEGAHGAMKEGGSSWRTLSSLIDHVYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIH8</accession>
    <name>A0A103XIH8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_006704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01005058">
        <property type="protein sequence ID" value="KVH91277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIH8"/>
    <dbReference type="STRING" id="59895.A0A103XIH8"/>
    <dbReference type="Gramene" id="KVH91277">
        <property type="protein sequence ID" value="KVH91277"/>
        <property type="gene ID" value="Ccrd_006704"/>
    </dbReference>
    <dbReference type="OMA" id="VMCPKEL"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="12">
        <location>
            <begin position="93"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="13">
        <location>
            <begin position="399"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH91277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="512" mass="57658" checksum="5F6163C2268E4F66" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIL1</accession>
    <name>A0A103XIL1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide-like helical</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004989">
        <property type="protein sequence ID" value="KVH91440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIL1"/>
    <dbReference type="STRING" id="59895.A0A103XIL1"/>
    <dbReference type="Gramene" id="KVH91440">
        <property type="protein sequence ID" value="KVH91440"/>
        <property type="gene ID" value="Ccrd_006540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16726" checksum="588C2D2659A13055" modified="2016-04-13" version="1">MSNLIPILVFSPTSSLPTHLSPPSSPFGRQFSSLPSPARRTSSLPSPARHTSPLNNGRKRIFIAKIIGSQLQLSTIQIPKTSGNPLPLRKKRRQTLEFRLSQIYQEGLLKLQAKDYEKARELLESVLKDHLLPNGQVDNSGSDGHLLQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIS7</accession>
    <name>A0A103XIS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIS7"/>
    <dbReference type="STRING" id="59895.A0A103XIS7"/>
    <dbReference type="Gramene" id="KVH91566">
        <property type="protein sequence ID" value="KVH91566"/>
        <property type="gene ID" value="Ccrd_006411"/>
    </dbReference>
    <dbReference type="OMA" id="IGPYEVY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04692">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF14">
        <property type="entry name" value="NUDIX HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="648" mass="73137" checksum="880B319FBB486444" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJU6</accession>
    <name>A0A103XJU6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004857">
        <property type="protein sequence ID" value="KVH92090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJU6"/>
    <dbReference type="Gramene" id="KVH92090">
        <property type="protein sequence ID" value="KVH92090"/>
        <property type="gene ID" value="Ccrd_005880"/>
    </dbReference>
    <dbReference type="OMA" id="VAWACVT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF2">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="37855" checksum="6B4618181954E12E" modified="2016-04-13" version="1">MIGWEDIYKVITAMFPLYAALILGYGSVKWWHMFKPDHCDAINQLNCYFIMPLFTFDFTTRINPYKMNFRFLAADGISKAIILLAIYIWAKFSTKGNYPWSITTFSLSTLNNTLVVGVPLMSAMYGPFGENLVIQSSILQFTIWIIILLVMYAFRSVNKSLDQAVTPNESPTDLEGNIEADSIPTRPSLLILLKVVGVKLAKNPNSYACILGLAWALVSNRWNLKMPSIIDGSVQIMSRAGLFMALQEKIIDCGATLTAYGMLLRFVVAPATMAVGSLAVGLRGDVLCIAIIQAALPQAIASFVFAKEYELHTSVLSTAVIFGTIVSIPVLIAYYVVLDLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK99</accession>
    <name>A0A103XK99_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004841">
        <property type="protein sequence ID" value="KVH92159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK99"/>
    <dbReference type="STRING" id="59895.A0A103XK99"/>
    <dbReference type="Gramene" id="KVH92159">
        <property type="protein sequence ID" value="KVH92159"/>
        <property type="gene ID" value="Ccrd_005809"/>
    </dbReference>
    <dbReference type="OMA" id="CKGATNE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009627">
        <property type="term" value="P:systemic acquired resistance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22269">
        <property type="entry name" value="DPBB_EG45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000005">
        <property type="entry name" value="Barwin-related endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044206">
        <property type="entry name" value="EGC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47295">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47295:SF11">
        <property type="entry name" value="RLPA-LIKE DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="5">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="14746" checksum="0FF691206AECB542" modified="2016-04-13" version="1">MTILFISFGLQASSQYTGIGTINAPPYVPSACYGYQDMGVMIAAASEALWDGGAVCGKYFEVTCTGGTNLGTPHPCSATPTVTVVITDFCPPPGCKGDLDLSHESFSAIADPAAGGIKISYQQSKKKKKKKKKEEERGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLH8</accession>
    <name>A0A103XLH8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLH8"/>
    <dbReference type="STRING" id="59895.A0A103XLH8"/>
    <dbReference type="Gramene" id="KVH92953">
        <property type="protein sequence ID" value="KVH92953"/>
        <property type="gene ID" value="Ccrd_004987"/>
    </dbReference>
    <dbReference type="OMA" id="YAPWWAP"/>
    <dbReference type="OrthoDB" id="1932364at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF183">
        <property type="entry name" value="DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="209" mass="22707" checksum="F3A58F53967A68A0" modified="2016-04-13" version="1">MAKSDQPSDSGIDTTLTRQNGIPAKKTRPPVYRGVRMRSWGKWVSEIRQPRKKSRIWLGTFSSPEMAARAHDVAALSIKGNSAILNFPQLKDLLPRPASISPRDVQAAAAMAAAMKEFSSSASYPDFSVPPSLASDDHVSGNSADELGEIIELPSLEGWLESPESSTELVLFDSVDGWMYRPCTAADIDFFPADFSGPVGEDSSFQTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLX8</accession>
    <name>A0A103XLX8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004792">
        <property type="protein sequence ID" value="KVH93168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLX8"/>
    <dbReference type="STRING" id="59895.A0A103XLX8"/>
    <dbReference type="Gramene" id="KVH93168">
        <property type="protein sequence ID" value="KVH93168"/>
        <property type="gene ID" value="Ccrd_004768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044249">
        <property type="entry name" value="XERICO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47258">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47258:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE XERICO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="313" mass="35755" checksum="8D42BF2A60DE5134" modified="2016-04-13" version="1">MGLSPYSNPCDAGVLCLILVNTAISISMMKEILRPILHLIGIRLASSSSSWSEEDDFSDQASADESIEHRGRPSETYMDEFRSRTPTLRYDSLSCTTKQECSVCLIDFRPDAEINRLSCGHVFHKSCLEKWLNYWNSWKGNFCIGKLSTSSWETCEKQNQLLEPTEAVFLFPNWERLEPTEALRWWRHLKEPGWVVGAQRQLILTLEDFRADKEGGVDVDSILVFFISSSRDSSPRDRLSCFSGCCAAVLVSSDIGSQEERLSSTQNRRKDQKWEIRKKKKQRDDLPFVVVAEAWLFFHLPLSIPGEDEDGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN00</accession>
    <name>A0A103XN00_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase D</fullName>
            <ecNumber evidence="10">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_004167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phospholipase D family. C2-PLD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004602">
        <property type="protein sequence ID" value="KVH93783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN00"/>
    <dbReference type="STRING" id="59895.A0A103XN00"/>
    <dbReference type="Gramene" id="KVH93783">
        <property type="protein sequence ID" value="KVH93783"/>
        <property type="gene ID" value="Ccrd_004167"/>
    </dbReference>
    <dbReference type="OMA" id="DSNPRWY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04015">
        <property type="entry name" value="C2_plant_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000027">
        <property type="entry name" value="Phospholipase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000025">
        <property type="entry name" value="Phospholipase D delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024632">
        <property type="entry name" value="PLipase_D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011402">
        <property type="entry name" value="PLipase_D_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF138">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12357">
        <property type="entry name" value="PLD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036470">
        <property type="entry name" value="PLD_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH93783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="802" mass="91490" checksum="4BBEDA03382E52A4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNH0</accession>
    <name>A0A103XNH0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004591">
        <property type="protein sequence ID" value="KVH93868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNH0"/>
    <dbReference type="STRING" id="59895.A0A103XNH0"/>
    <dbReference type="Gramene" id="KVH93868">
        <property type="protein sequence ID" value="KVH93868"/>
        <property type="gene ID" value="Ccrd_004074"/>
    </dbReference>
    <dbReference type="OMA" id="HPGYMAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF217">
        <property type="entry name" value="IQ MOTIF, EF-HAND BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="6">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="43001" checksum="5A4599A941577ACC" modified="2016-04-13" version="1">MGKAIRWLKALFGFKKEKNLKQESNSGDRKNKNPSCIRRSGRNPTNSPVKSPLQTPLYNNVNHHSDEQNKRAIQVATATAAAADAAVAAAQAAVAFVRLTSQNRLTTAREHAAAIKIQAFFRGFLSRKALKALKSLVKLQAVVRGYLVRKEAAATLQGMEALLRAQSSVCAQRFRRQDDKFHPRRSIVSTHRSIFLVIIMKKNDSFMETVVMRKRANEARSKRISASLQIPSDGRLSCVEVGPEEPKSRLTRANTWAWTPDSGTQTPYHLAIPNHHEFEPRFSTTQNTPRFAYSCGPYGFYEGVSKDDSFASHPGYMANTKSFRAKVRSHSAPKQRPDFGFGVVKKRVEVECGPRMEKSKSPSLLEVNNFKNFVMSRIGKSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPQ8</accession>
    <name>A0A103XPQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004538">
        <property type="protein sequence ID" value="KVH94656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPQ8"/>
    <dbReference type="Gramene" id="KVH94656">
        <property type="protein sequence ID" value="KVH94656"/>
        <property type="gene ID" value="Ccrd_003280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="18178" checksum="B67FCEA867C48EEF" modified="2016-04-13" version="1">MTDFKFQIRGSEMTMHITLVFLFEIGKGSCLQQPDIAGTSIHSYSKIFDTTGWDHRNPTDALALNSKSRMGSRQDNPTVRNEVAGDFLSLLKEWENLCKEFCLLGSKHAEDTSIKSEESNQLRPRPVLTATLPLSLGPLVLVQHRQHSNNKDIEAQQQQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQV7</accession>
    <name>A0A103XQV7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">Ccrd_002664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQV7"/>
    <dbReference type="STRING" id="59895.A0A103XQV7"/>
    <dbReference type="Gramene" id="KVH95213">
        <property type="protein sequence ID" value="KVH95213"/>
        <property type="gene ID" value="Ccrd_002664"/>
    </dbReference>
    <dbReference type="OMA" id="GCIARNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF14">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="200" mass="22156" checksum="4EAC41C363B503D8" modified="2016-04-13" version="1">MESTGAAASGGNGTLNPQHNDASPAESTVMATTSSSDDPKQNLNQVINSIQKSLGIIHQLYLTVSSFNVSSQLPLLQRLNTLVLEMDNMTKLSEKCNIQVPMEVLNLIDDGKNPDEFTREVLNSCIAKNQITKGKTDAFKGLRRHLLEELEQAFPDEVEDYREIRASSAAESVRLAQAQSILPNGDEWHFNEKQNTQKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR34</accession>
    <name>A0A103XR34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004392">
        <property type="protein sequence ID" value="KVH95348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR34"/>
    <dbReference type="STRING" id="59895.A0A103XR34"/>
    <dbReference type="Gramene" id="KVH95348">
        <property type="protein sequence ID" value="KVH95348"/>
        <property type="gene ID" value="Ccrd_002568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF6">
        <property type="entry name" value="PROTEIN PAM71, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="264" mass="29227" checksum="BE76D2D9D8FDB5CC" modified="2016-04-13" version="1">MGSMTTLCSSESVFSMRRMASLSTQSSSSSSSSSSSSKPSKFFRCFLDSNVSSVHTSQSRVFFRQHCIKLHDRRFRQFQHSRYHMNVFRSDGNDPTKLAHNVEDWECSTSGKSNSRNMLTAKTSLPSKDLSIDTSRNSYLKFLLFFGILTLQDAQSALAGSDVANLLQSSSFFGDLSDLSTGFASAFLLIFFSELGDKTFFIAALLAARNSAAVIFLGTFGALGVMTIISVVLGRTFHYVDEILPFRSTLHNIIFLPFSIIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XR63</accession>
    <name>A0A103XR63_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_002609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XR63"/>
    <dbReference type="STRING" id="59895.A0A103XR63"/>
    <dbReference type="Gramene" id="KVH95309">
        <property type="protein sequence ID" value="KVH95309"/>
        <property type="gene ID" value="Ccrd_002609"/>
    </dbReference>
    <dbReference type="OMA" id="HADSVRW"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.10:FF:000060">
        <property type="entry name" value="UDP-glucose 4-epimerase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH95309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="334" mass="36546" checksum="745562178CA9759C" modified="2016-04-13" version="1">MGPPQCILVTGGAGYIGSHTVLQLLLEGHKTVVVDNFDNSSQVAINRVQKLAGDHGRNLFDAVIHFSGLKAVGESVKNPLIYYDNNIIGTLILLEVMNAHGCKKLVFSSSATVYGWPKEVPCTEEFPLSAANPYGRTKNEPLQLMIEEICQDIYASDSKWKIILLRYFNPVGAHPSGQIGEDPRGVPNNLMPFVQQVAVGRLPTLKVFGTDYSTKDGTGVRDYIHVVDLADGHTAALRKLSDPKIGCEVYNLGTGKGTSVLEMVAAFEKASGKRIPLVMAGRRPGDAEVVYASTGKAERDLNWKAKYGIDDMCRDQWNWASKNPYGYLTKDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRN2</accession>
    <name>A0A103XRN2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004381">
        <property type="protein sequence ID" value="KVH95633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRN2"/>
    <dbReference type="STRING" id="59895.A0A103XRN2"/>
    <dbReference type="Gramene" id="KVH95633">
        <property type="protein sequence ID" value="KVH95633"/>
        <property type="gene ID" value="Ccrd_002345"/>
    </dbReference>
    <dbReference type="OMA" id="CINDNDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06148">
        <property type="entry name" value="Egl_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="362" mass="40223" checksum="0DFF60408A7FDA2A" modified="2016-04-13" version="1">MHVQFQSENNTAVYLSAVKIGGEVFVICLNGSIIAMASSLSSPNQLTCGEIVPIHIVTHASQLPPEFLEPSPDKKLVIGFDCEGVDLCRNGTLCIMQLAFPDAIYLVDAIEGGKTLVEACKPALESSNVTKVIHDCKRDSEALYFQFNIKLHNVFDTQIAYTLIEVQEGGTKVPDDYISFVGLLADPRYCGISYLEKQEVRVLLRQDPNFWKYRPLSELMVRAATDDVRFLLYIYNKMVVKMNQKSLWYLAVRGALYCRCFCITDNDYADWPPLPPIPETLVTDDNAPEEEVLSVVDVPPGKMGLVIGRKGASILAIKESCNAEIFIGGAKGPPDKVFVIGPVKQVRKAEAILRGRMVETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XST3</accession>
    <name>A0A103XST3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01004345">
        <property type="protein sequence ID" value="KVH96230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XST3"/>
    <dbReference type="STRING" id="59895.A0A103XST3"/>
    <dbReference type="Gramene" id="KVH96230">
        <property type="protein sequence ID" value="KVH96230"/>
        <property type="gene ID" value="Ccrd_001683"/>
    </dbReference>
    <dbReference type="OMA" id="WRYRGFP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF24">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="79"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="283"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="63766" checksum="0A9128A92DE3B6D6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU41</accession>
    <name>A0A103XU41_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004096">
        <property type="protein sequence ID" value="KVH96904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU41"/>
    <dbReference type="Gramene" id="KVH96904">
        <property type="protein sequence ID" value="KVH96904"/>
        <property type="gene ID" value="Ccrd_001004"/>
    </dbReference>
    <dbReference type="OMA" id="YCEMRSS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010019">
        <property type="term" value="P:chloroplast-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF5">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32912" checksum="041D96A8804D6DAD" modified="2016-04-13" version="1">MSSAAYNRLHGLFKNSTATATATGTATGTAVSTTKKIIKEKTKRPKKSPASSTSTTAAAGGTVVSRSKTENLSFEPLPMSQLTTSLANLKMFIDTFKRTSNTGPFRYSYKYYDDAVSHLARAKQHAYIEEILEHQKRYKTDMTKEAFVVRLISLYGKSRMFDHARKLFDEMPELNCPRTVLSANVSQLMSELFHELREELSIELDDVSYNVVVKAFCEIDAIDSALQMADEMEKNGFECNVYTYNTILDALYGKGNILDADKIWDVMKSKNLDPDVRTYNAKLRGLIVANRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVG4</accession>
    <name>A0A103XVG4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003824">
        <property type="protein sequence ID" value="KVH97620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVG4"/>
    <dbReference type="Gramene" id="KVH97620">
        <property type="protein sequence ID" value="KVH97620"/>
        <property type="gene ID" value="Ccrd_000312"/>
    </dbReference>
    <dbReference type="OMA" id="GQTQRKQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044787">
        <property type="entry name" value="HHO5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058673">
        <property type="entry name" value="HHO5-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR HHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26575">
        <property type="entry name" value="HHO5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH97620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="388" mass="42673" checksum="D1E59A4FAA1C35B5" modified="2016-04-13" version="1">MVFDNNSSDFEEKMQRCREYMEALESERRKIQVFERELPLCLELVTRAIEGCRQQMSGTTNDYFNGQSECSEQTSSEGPVLEEFIPIKRTSSADEDDQEHQHQHQEPNHKPMNICTKDKSSSSSKKSDWLRSAQLSIQTPDPVIGFLRNFQELSPKRVPVVEVKRNGCGAFHPFKKEKNPEAAPAAGTAKLSTTPATDPTAAASSTAETGSGSGGCGGSKSEDKGQSNRKARRCWSPELHRRFLHALQQLGGAHVATPKQIRELMKVDGLTNDEVKSHLQKYRLHTRRPSPTIHNNNPQTPQFVVVGGIWMPPPEYTTMAATSTPTSGDTNNSKGVYAPIASHQPSIAEASVSLNKSNSGEKDGGHFHLQESPSTSSSTHTTTASPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVU6</accession>
    <name>A0A103XVU6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVU6"/>
    <dbReference type="STRING" id="59895.A0A103XVU6"/>
    <dbReference type="Gramene" id="KVH97829">
        <property type="protein sequence ID" value="KVH97829"/>
        <property type="gene ID" value="Ccrd_000045"/>
    </dbReference>
    <dbReference type="OMA" id="NENDIMV"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000033">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057136">
        <property type="entry name" value="At2g35280_TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044508">
        <property type="entry name" value="At5g50450/At1g67340-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758">
        <property type="entry name" value="MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758:SF16">
        <property type="entry name" value="ZINC FINGER, MYND-TYPE, TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23310">
        <property type="entry name" value="TPR_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="375" mass="40803" checksum="AB842863C88D259E" modified="2016-04-13" version="1">MRTRRGICYPEVNTMCYEKRRRDGNLAGAQMILSRKRLKSSSGTPVVNASSHCDFFDTLPDDIVLSILAKLGSTVGCPADFISVLSTCKRFNGLGLHSLVLSKASSNCFAVKAKKWSESSHRFLKRCSDAGNAEASYTLGMIRFYCLQNRGGGASFMAKAAIRSHAPALYSLAVIQFNGSGGLKNDKDLRAGVALCARAAFLGHIDALRELGHCLQDGYGVSKNIAEGRRLLIQANARELATVLSTTPATLLSGKHLTWNPLPHLMGPGCPLLSDFGCNVPAPTPHPANQFLSDWFSDKPPCPELRLCSHGGCGRPETRRHEFRRCSVCGDVNYCSRACQALDWKLRHKAVCRPGVDNGGFNGNVNENDIMVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWL9</accession>
    <name>A0A103XWL9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003807">
        <property type="protein sequence ID" value="KVH98161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWL9"/>
    <dbReference type="STRING" id="59895.A0A103XWL9"/>
    <dbReference type="Gramene" id="KVH98161">
        <property type="protein sequence ID" value="KVH98161"/>
        <property type="gene ID" value="Ccrd_023616"/>
    </dbReference>
    <dbReference type="OMA" id="QANIMSK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF54">
        <property type="entry name" value="ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="424"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="831"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="929" mass="103603" checksum="B64E0DA1C78EDEC6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWR7</accession>
    <name>A0A103XWR7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_023479</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="LEKV01003803">
        <property type="protein sequence ID" value="KVH98301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWR7"/>
    <dbReference type="Gramene" id="KVH98301">
        <property type="protein sequence ID" value="KVH98301"/>
        <property type="gene ID" value="Ccrd_023479"/>
    </dbReference>
    <dbReference type="OMA" id="ATGFRRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000537">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF3">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="21">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="504"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVH98301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="791" mass="89061" checksum="CD89D2FD16F184AF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX24</accession>
    <name>A0A103XX24_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003795">
        <property type="protein sequence ID" value="KVH98480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX24"/>
    <dbReference type="STRING" id="59895.A0A103XX24"/>
    <dbReference type="Gramene" id="KVH98480">
        <property type="protein sequence ID" value="KVH98480"/>
        <property type="gene ID" value="Ccrd_023290"/>
    </dbReference>
    <dbReference type="OMA" id="CEYMERY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="262" mass="29370" checksum="4AB48FB1E3B05169" modified="2016-04-13" version="1">MGCIVNKTADAKADRLSRWSATGISFPDEVLELDRSVRTLDLTHNKLADIPEEISRLTNMQRLILADNVIERLPSNVGKLQSLKFLILDQNRVTILPDEMGQLVRLERLSILGNQLTGLPDTIGSLRNLLLLNVSKNQLKFLPESIGSCFSLEELQANENSIEELPPSIPPSLLKSCKALQNISLHGNPISMDQFQTMEGFQEFEARRKRKFDKQIDSNVMIGSKGLDEGVDLMSRGLEAACMINDDGLWLWTSARPSLQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXE8</accession>
    <name>A0A103XXE8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_023115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003771">
        <property type="protein sequence ID" value="KVH98661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXE8"/>
    <dbReference type="STRING" id="59895.A0A103XXE8"/>
    <dbReference type="Gramene" id="KVH98661">
        <property type="protein sequence ID" value="KVH98661"/>
        <property type="gene ID" value="Ccrd_023115"/>
    </dbReference>
    <dbReference type="OMA" id="VWGGTWL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018221">
        <property type="entry name" value="Glyco_hydro_9_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00592">
        <property type="entry name" value="GH9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="114"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH98661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="595" mass="66436" checksum="2D8847E5D2D918BF" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ15</accession>
    <name>A0A103XZ15_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpc2-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003461">
        <property type="protein sequence ID" value="KVH99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XZ15"/>
    <dbReference type="Gramene" id="KVH99516">
        <property type="protein sequence ID" value="KVH99516"/>
        <property type="gene ID" value="Ccrd_022248"/>
    </dbReference>
    <dbReference type="OMA" id="GEYYHED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF28">
        <property type="entry name" value="YEMANUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="782" mass="85705" checksum="CFF1307B12C71C4F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ74</accession>
    <name>A0A103XZ74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SOFL plant protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003437">
        <property type="protein sequence ID" value="KVH99604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ74"/>
    <dbReference type="STRING" id="59895.A0A103XZ74"/>
    <dbReference type="Gramene" id="KVH99604">
        <property type="protein sequence ID" value="KVH99604"/>
        <property type="gene ID" value="Ccrd_022162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044670">
        <property type="entry name" value="SOFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33347">
        <property type="entry name" value="OSJNBA0091C07.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33347:SF34">
        <property type="entry name" value="PROTEIN SOB FIVE-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11295" checksum="5387706A28A2A40A" modified="2016-04-13" version="1">MNNMSTCECSSGCESGWTMYLDQSLNSGDGKWSYHEDDEDLSMVSDASSGPTRHKIHDEDEDEESKYGFCYGLNSQEKRKTRLKKDDDDDTASSTVFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZD4</accession>
    <name>A0A103XZD4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003429">
        <property type="protein sequence ID" value="KVH99631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZD4"/>
    <dbReference type="STRING" id="59895.A0A103XZD4"/>
    <dbReference type="Gramene" id="KVH99631">
        <property type="protein sequence ID" value="KVH99631"/>
        <property type="gene ID" value="Ccrd_022132"/>
    </dbReference>
    <dbReference type="OMA" id="FHDVQMY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="242" mass="27226" checksum="61996CA4F43B43F1" modified="2016-04-13" version="1">MVSSQSESGLLSSEGDSQRTQYPYVTGTSVIGIKYKDGILMAADMGGSYGSTIRYKSVERLKQVGKHSLLGASGEISDFQEILRYLDELILHDNMWDDGNSLGPKEVHNYLTRIMYNRRNKFDPLWNSLVLGGVKNGQKYLGSVSMIGVHFEDSHVATGFGNHLARPILREEWREDLSFEEGVKLLEKCMRNLLYRDRSAVNKLQIAKITEDGLTISQPYSLKTFWNFGAFQNPTVGAEGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZN9</accession>
    <name>A0A103XZN9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003412">
        <property type="protein sequence ID" value="KVH99846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZN9"/>
    <dbReference type="Gramene" id="KVH99846">
        <property type="protein sequence ID" value="KVH99846"/>
        <property type="gene ID" value="Ccrd_021919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="12078" checksum="9173D11F5C430D25" modified="2016-04-13" version="1">MQQRLLIQRGIVYRVRAFFFNLNQLRFRIRIVHKVKDIRRRLDVIAANRSNFHLSPITKSVDARVGGDRRSIETSSLIRLSKTYGRDAEMGMITKKICSKDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1S1</accession>
    <name>A0A103Y1S1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003162">
        <property type="protein sequence ID" value="KVI00942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1S1"/>
    <dbReference type="Gramene" id="KVI00942">
        <property type="protein sequence ID" value="KVI00942"/>
        <property type="gene ID" value="Ccrd_020797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18439" checksum="6800EDD9C68E503E" modified="2016-04-13" version="1">MSGPVYLRNKCHGGTVQWHVIDSRQLDDAISLLIKLNSLVRGESGGSSLAIQSLIDSLTFFSLRNLSTNFVNQIPFQITILLRRSPQLSAWVVLDQRVPTGTSPNHPITESELVHTEQESRNLDHVAVPTLALRRSSKIPKQPSYFDDFVCNHISSDASMPYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y237</accession>
    <name>A0A103Y237_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003133">
        <property type="protein sequence ID" value="KVI01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y237"/>
    <dbReference type="STRING" id="59895.A0A103Y237"/>
    <dbReference type="Gramene" id="KVI01086">
        <property type="protein sequence ID" value="KVI01086"/>
        <property type="gene ID" value="Ccrd_020649"/>
    </dbReference>
    <dbReference type="OMA" id="PMWAPQS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12345">
        <property type="entry name" value="RRM2_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000650">
        <property type="entry name" value="Polyadenylate-binding protein RBP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000236">
        <property type="entry name" value="Polyadenylate-binding protein RBP45C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF67">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN RBP45-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="404" mass="45058" checksum="078707C9A5A0AF22" modified="2016-04-13" version="1">MQPATTAVMDPRYQQQWMMMNQQQPPPPQQQYHQQQPQQMYTYNQQPPPAAAVPPVLPQYPVAATAGTGPNHQPASADEIRTLWIGDLQYWMDEQYLVSCFAQSGEVISAKVIRNKQTGQSEGYGFIEFVNRPAAERHLQTYNGTLMPNVEQNFRLNWASFGVGEKRADGAPDFTIFVGDLAADVTDYTLQETFRAHYPSVKGAKVVTDRMTGRTKGYGFVKFGDETEQLHAMTEMNGRLCSTRPMRIGPAANKNTVGGQQYPKGHQGDLSCKGLALIPAEIVTPILHTRIPKEHRTRRIQLIQLSCAEEALRMLQGTQLGGQTVRLSWGRSPSNKQPQQVEQSQYSGGGGYYGYGQGYETYGYAPVAQDPTMYYGGYAAGYGGYPQVQQQPQPQIQPQPQQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2B6</accession>
    <name>A0A103Y2B6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2B6"/>
    <dbReference type="Gramene" id="KVI01206">
        <property type="protein sequence ID" value="KVI01206"/>
        <property type="gene ID" value="Ccrd_020531"/>
    </dbReference>
    <dbReference type="OMA" id="ITANWQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052732">
        <property type="term" value="F:phosphoethanolamine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042131">
        <property type="term" value="F:thiamine phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF19">
        <property type="entry name" value="THIAMINE PHOSPHATE PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="19966" checksum="2002E2C6D6907DA6" modified="2016-04-13" version="1">MMILWDFDRTIMDDDSDRWVVVEMGLTQIFNQLRETLPWNSLMDRMMAELHPQGKTIEDIANCLNRVRLHPQIVSAIRSAHGSVLNQLQDSRSENGKKHVIIYIGDGGGDFCPTLKLGEEDHVMPRKNFPLHHLISKSSVPIKPQVHEWMDGEELNKILLRLTDSDSAEKQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y405</accession>
    <name>A0A103Y405_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_019597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002663">
        <property type="protein sequence ID" value="KVI02112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y405"/>
    <dbReference type="STRING" id="59895.A0A103Y405"/>
    <dbReference type="Gramene" id="KVI02112">
        <property type="protein sequence ID" value="KVI02112"/>
        <property type="gene ID" value="Ccrd_019597"/>
    </dbReference>
    <dbReference type="OMA" id="ANGCKSN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000118">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI02112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="730" mass="81088" checksum="9261FC1F269697C0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4Y1</accession>
    <name>A0A103Y4Y1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002649">
        <property type="protein sequence ID" value="KVI02615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4Y1"/>
    <dbReference type="STRING" id="59895.A0A103Y4Y1"/>
    <dbReference type="Gramene" id="KVI02615">
        <property type="protein sequence ID" value="KVI02615"/>
        <property type="gene ID" value="Ccrd_019109"/>
    </dbReference>
    <dbReference type="OMA" id="GYKKLLW"/>
    <dbReference type="OrthoDB" id="2013003at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053223">
        <property type="entry name" value="Prob_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067:SF12">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="52803" checksum="A7BF5727F88047BE" modified="2016-04-13" version="1">MASFSPSPLLTLCFITLFSIFIFISTILNPNFISNLNSYNSHDFPPVLPSSLHHQISNLQTQFGILLEKIHSEEKESSKTLSRFSDQVLRVALLLDKLSESLSGLHGDTTIATSVTYQDSTQPEETEAENHEEEEEERFIELSEKVLHYTNPKPNRLPDGKKNFMDLEAINPSIGLGCTRMTANLDRYSTYKPYSNCPDDSEFAQKLILRGCDPLPRRRCFSRSPPNYNNPLPLSSSLWTQPNDSNILWNHYTCKNYNCLISIDTKNKQGFHKCADCFNLSKKGWEVPLTDSESAEISIDEVLALKRTEIRIGLDFSPTTGSFAALMRERNVTIASATLNLGAPFNEVIALRGLLPLYVSIGSRLPFFDNTLDLVHSTLFLDGWIGFELLEYVVFDWDRVLRPKGMLWLDRFFCKKEDMKGYISVIEKLKYRKVLWRVVTKKDRVENELFLSAVLEKPLRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6R2</accession>
    <name>A0A103Y6R2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fringe-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002342">
        <property type="protein sequence ID" value="KVI03566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6R2"/>
    <dbReference type="STRING" id="59895.A0A103Y6R2"/>
    <dbReference type="Gramene" id="KVI03566">
        <property type="protein sequence ID" value="KVI03566"/>
        <property type="gene ID" value="Ccrd_018146"/>
    </dbReference>
    <dbReference type="OMA" id="HPYCRWK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000006">
        <property type="entry name" value="Fringe-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54631" checksum="39290E9E998BF6B6" modified="2016-04-13" version="1">MLTATASQHPHRSALATLRYSFFWLLIALLILYLLYSSKLLLNQTECGHFSNHLSTTENLQNATDLAGISSPIPRFDTELKHIVFGIAASSGLWRWRKEYIKLWWRPGETRGAVWIDNQVRMKKNESLPEIHVSRDTSKFRYTNRQGTRSAIRISRVVSETMKLGLEDVRWLVMGDDDTVFILENLVRILSKYNHEQYYYIGSSSESHVQNIFFSYTMAYGGAGFAISYPLALELEKMQDRCIQRYPSLYGSDDRIQACMAELNFDVYGNLLGLLGSHPVAPLVSLHHLDIVDPVFPGMSRTESLRHLLEAAKYDSASIAQQSICYDKTREWSILVSWGFAIQIVRGMVSPRELDFPTRTFLNWYKKLDYMAYAFNTRPVTRHPCQKAFVFYMSRTMYDKARKKIIGIYTLHNERHPTCRWKMESPEKIDNIVVLKSPDNHRWQKKGTMYLWVDGCRKGEVVEWQSSKSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y788</accession>
    <name>A0A103Y788_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002328">
        <property type="protein sequence ID" value="KVI03821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y788"/>
    <dbReference type="Gramene" id="KVI03821">
        <property type="protein sequence ID" value="KVI03821"/>
        <property type="gene ID" value="Ccrd_017877"/>
    </dbReference>
    <dbReference type="OMA" id="FKLDGLW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000571">
        <property type="entry name" value="Guanine nucleotide-binding protein-like NSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="139"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="617" mass="68544" checksum="8DD883621F4EBDDC" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7Y2</accession>
    <name>A0A103Y7Y2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002301">
        <property type="protein sequence ID" value="KVI04176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7Y2"/>
    <dbReference type="Gramene" id="KVI04176">
        <property type="protein sequence ID" value="KVI04176"/>
        <property type="gene ID" value="Ccrd_017516"/>
    </dbReference>
    <dbReference type="OMA" id="DESHIYI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF61">
        <property type="entry name" value="UBIQUITIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="91" mass="10246" checksum="4835FE98CFDB5BEF" modified="2016-04-13" version="1">MRVVVEILTGKLFYVQIGDNATVLDLKKEIGAQEKLPDDRLILLLCNNLMNENEALLVEYGVEDGSHLYLFFDSLKDGSTHQFLLSTSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9C5</accession>
    <name>A0A103Y9C5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001900">
        <property type="protein sequence ID" value="KVI04917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9C5"/>
    <dbReference type="STRING" id="59895.A0A103Y9C5"/>
    <dbReference type="Gramene" id="KVI04917">
        <property type="protein sequence ID" value="KVI04917"/>
        <property type="gene ID" value="Ccrd_016758"/>
    </dbReference>
    <dbReference type="OMA" id="IPENYNH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090447">
        <property type="term" value="F:glycerol-3-phosphate 2-O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010143">
        <property type="term" value="P:cutin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06551">
        <property type="entry name" value="LPLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056462">
        <property type="entry name" value="HAD_RAM2/GPAT1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486">
        <property type="entry name" value="ANCIENT UBIQUITOUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486:SF54">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23270">
        <property type="entry name" value="HAD_RAM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="9">
        <location>
            <begin position="294"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI04917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="510" mass="56906" checksum="3B0F3BD4ECF32352" modified="2016-04-13" version="1">MESVVSELEGTLLKNQDPFSYFMLVAFEASGLIRFTLLLLFWPIIKLLDWCRKPEVGLKLAIFLATAGVPMSEIESVARAVLPKFYFDDIDLEAWRVFNLGDRRVVVTQMPRLMVERFVKEHLRADEVIGTELVVSRFGFATGLVQDGGFGSSVCDRVAAIFDGQQPSLGLGRCHSGSSFLSLCKRLQINLQLMGFISLQEQVNASYMIKDQKQDMRPMPVIFHDGRLVKRPTPSTALLILLWIPLGVILAIIRMTIGVLLPMWAIPYMASIFGGKVVVKGVPPPPPSGSNAGVLFVCTHRTLMDPVVLSTVLQRSIPAVTYSISRLSEILSPIPTVRLTRIRHVDAERIKKELSQGDLVVCPEGTTCREPFLLRFSALFAELTDRIVPVAMNYRVGFFHATTARGWKGLDPIFFFMNPRPVYEVTFLNQLPAEATCSSGKSPHDVANYVQRILAATLGFECTNFTRKDKYRVLAGNDGTVSYTTVMDRVQKMGKTVKKVVGTFKPFVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9V2</accession>
    <name>A0A103Y9V2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl endopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9V2"/>
    <dbReference type="STRING" id="59895.A0A103Y9V2"/>
    <dbReference type="Gramene" id="KVI05196">
        <property type="protein sequence ID" value="KVI05196"/>
        <property type="gene ID" value="Ccrd_016480"/>
    </dbReference>
    <dbReference type="OMA" id="MQHELCT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="496"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="749" mass="84742" checksum="F38E0CF3E5855DFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC37</accession>
    <name>A0A103YC37_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001835">
        <property type="protein sequence ID" value="KVI06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC37"/>
    <dbReference type="Gramene" id="KVI06336">
        <property type="protein sequence ID" value="KVI06336"/>
        <property type="gene ID" value="Ccrd_015317"/>
    </dbReference>
    <dbReference type="OMA" id="WHAFASG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF277">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HT1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22812" checksum="65ED72F870C7B355" modified="2016-04-13" version="1">MKKSNWFKQISNSGKLERRLSLGEYKRAVSWSKYLVSSGGEIKAKGEEEEDIEWSADMSQLFIGNKFATGRHSRVYRGVYKQKDVAIKLISQPEEDGDLASMLEKQFTSEVVLLFRLQHPNIITNARPPLPGTCPSAFRQLIRRCWSSKPEKRLGFDEIVRILERYRACVEEDPNFLTWYEPGKGGGSLLGCLRKGKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCH5</accession>
    <name>A0A103YCH5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_015120</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001806">
        <property type="protein sequence ID" value="KVI06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCH5"/>
    <dbReference type="STRING" id="59895.A0A103YCH5"/>
    <dbReference type="Gramene" id="KVI06531">
        <property type="protein sequence ID" value="KVI06531"/>
        <property type="gene ID" value="Ccrd_015120"/>
    </dbReference>
    <dbReference type="OMA" id="ACHPNNY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF38">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="17">
        <location>
            <begin position="340"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="19">
        <location>
            <begin position="627"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="18">
        <location>
            <begin position="815"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1254" mass="141133" checksum="8B7B5B202A0A708D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCM5</accession>
    <name>A0A103YCM5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box associated interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001781">
        <property type="protein sequence ID" value="KVI06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCM5"/>
    <dbReference type="Gramene" id="KVI06621">
        <property type="protein sequence ID" value="KVI06621"/>
        <property type="gene ID" value="Ccrd_015025"/>
    </dbReference>
    <dbReference type="OMA" id="ANETWGM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16982" checksum="BC368E4D7E9B4179" modified="2016-04-13" version="1">MELTSRDFGSSYSWTIVSLDLAKETYGEVLQPVYDEGDKDLALGSLVDGLCVLCNYRGNRADVWVIKVYGVKDSWTRLASIPYVTDPGRDQFSVPLCISNDGKVLLQFGSKLVLYDIKNGSSSEIQNFDECLKAYTIVESMVSPDAPIRHWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD32</accession>
    <name>A0A103YD32_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">chorismate synthase</fullName>
            <ecNumber evidence="5">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01001554">
        <property type="protein sequence ID" value="KVI06884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD32"/>
    <dbReference type="STRING" id="59895.A0A103YD32"/>
    <dbReference type="Gramene" id="KVI06884">
        <property type="protein sequence ID" value="KVI06884"/>
        <property type="gene ID" value="Ccrd_014761"/>
    </dbReference>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000003">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="415" mass="45016" checksum="8178A44FF1B08D21" modified="2016-04-13" version="1">MASSLSTKPFLGALSSDEPSRFGSLRHSDLRSAVLRISTSRQSRPRTLGVGCVVDGCPPRIPLSEADLQVDLDRRRPGQSRITTPRKETDTCHIYSGVAEGFTTGSPIMIKVPNTDQRGKDYSEMSMAYRPSHADATYDFKYGTRSVEGGGRSSARETIGRVAAGAVAKKILKAYAGTEILAYVSQAHKIVLPEGLVDHETLTLDQVESNIVRCPDPEYAEKMIAAIDAVRVRGDSVGGVVTCIVRNVPRGLGSPVFDKLEAELAKAALSLPATKGFEFGSGFAGTFLTGSEHNDEFFMDEHGRVRTRTNRSGGIQGGISNGETIHMRIAFKPTSTIGRKQNTVTRDKKETELIARGRHDPCVVPRAVPMVEASVALVLIDQLLAQYAQCQLFPINPEFQEPLQMPTLEQSGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE79</accession>
    <name>A0A103YE79_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE79"/>
    <dbReference type="STRING" id="59895.A0A103YE79"/>
    <dbReference type="Gramene" id="KVI07478">
        <property type="protein sequence ID" value="KVI07478"/>
        <property type="gene ID" value="Ccrd_014172"/>
    </dbReference>
    <dbReference type="OMA" id="THFNIEL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF768">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="38849" checksum="67751BBB405F96B3" modified="2016-04-13" version="1">MEKEDEKGRGGGDYHVQVDTGSDLLWVNCAGCANCPRNSDLGISLMLYNPKSSSSSKMITCDQDFCTSTLDSSNNECIVGMRCSYLVKYGDGSSTTGSTQQALDGILGLGQANSSIISQLAMAKKVKKTFSHCLSGSTGGGIFAIGEVVEPKVNTTPIIPKETHFNIELKAIEVGDEFLRLPRDIYDGRTRRGAIIDSGTTLAYFPNEIYNQLMRSIMVAQPNMKPHIVDHQFKCYKYLGDVDDGFPVVTFHFTNTLPMKVYPHQYLFQVQDGKDVILLGDLVLTDKLVTYNMEDQTVGWTEYNCSSSIKVKDEETGMVYERLDKFLTESEISFAASVVENRRRDAQKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEI7</accession>
    <name>A0A103YEI7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Senescence regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001501">
        <property type="protein sequence ID" value="KVI07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEI7"/>
    <dbReference type="STRING" id="59895.A0A103YEI7"/>
    <dbReference type="Gramene" id="KVI07610">
        <property type="protein sequence ID" value="KVI07610"/>
        <property type="gene ID" value="Ccrd_014019"/>
    </dbReference>
    <dbReference type="OMA" id="VNVPVWQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083:SF123">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="250" mass="27261" checksum="E3709C24140918C3" modified="2016-04-13" version="1">MAKSSTAGSISAVSYSPSSSLSSSPALRFLGHLTVPEKSSDLNNGGIEEFHESDVFWSSSSDVSDIPSPSNVSSSPPIHRQYNSGLYAALSDDQHPLVRRKHAMSPSQSAATAARTIPPVALRRSSEHSVGYHQSAPVNVPVWPKNKTNNYLGQFDEVVDNVVEEEDEGEMVPPHEIVARSYVTFSVFEGAGRTLKGRDLCRVRNAVFQKTDIQAFGYSMRRYAKMKGMVAADVDLCENGIMMEHLVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEN1</accession>
    <name>A0A103YEN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001494">
        <property type="protein sequence ID" value="KVI07704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEN1"/>
    <dbReference type="STRING" id="59895.A0A103YEN1"/>
    <dbReference type="Gramene" id="KVI07704">
        <property type="protein sequence ID" value="KVI07704"/>
        <property type="gene ID" value="Ccrd_013946"/>
    </dbReference>
    <dbReference type="OMA" id="GWTKDMV"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001093">
        <property type="term" value="F:TFIIB-class transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053340">
        <property type="entry name" value="PTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48428">
        <property type="entry name" value="PLANT-SPECIFIC TFIIB-RELATED PROTEIN PTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48428:SF1">
        <property type="entry name" value="PLANT-SPECIFIC TFIIB-RELATED PROTEIN PTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="1">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="519" mass="59060" checksum="CADFA84FC12CEA68" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEN7</accession>
    <name>A0A103YEN7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_013948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001495">
        <property type="protein sequence ID" value="KVI07686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEN7"/>
    <dbReference type="STRING" id="59895.A0A103YEN7"/>
    <dbReference type="Gramene" id="KVI07686">
        <property type="protein sequence ID" value="KVI07686"/>
        <property type="gene ID" value="Ccrd_013948"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="35670" checksum="47E04E07B7536213" modified="2016-04-13" version="1">MIKYIQMKLDDNLSDIKCPAMACNHSLEPLSCRPKIARQLFDKWCDVLCESAVLKLDRVYCPNQDCSELIVNECGERDLKRCLCPNCMKPFCFWCKVPWHAGYMCEESGETRDENDVAFGVLAERKGWIRCPTCQHFVELADGCTIVRCSYESKLVDSISKEILETLCDGPLDVTKEVEVLVLLLEKSSEKVNMDSKSLACMNNLRILQVCYLELKNLEHTIERNQWNESEVKFDLKLWDESKVKFSGILEFLSNELRLFYWHGCPFKFLPSEFCPVNIVAIDMSYSPIESLWTTPKVFTCSYIYFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHB9</accession>
    <name>A0A103YHB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHB9"/>
    <dbReference type="STRING" id="59895.A0A103YHB9"/>
    <dbReference type="Gramene" id="KVI09109">
        <property type="protein sequence ID" value="KVI09109"/>
        <property type="gene ID" value="Ccrd_012523"/>
    </dbReference>
    <dbReference type="OMA" id="GAIDFQF"/>
    <dbReference type="OrthoDB" id="773121at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000005">
        <property type="entry name" value="ethylene-responsive transcription factor RAP2-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF197">
        <property type="entry name" value="OS12G0582900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="405" mass="45658" checksum="AC9D96E777A6F949" modified="2016-04-13" version="1">MARKRKQANDHERIMSERNSDHPEENMTWDDMVKESAAAAALGGPRRARKRFVGVRQRPSGRWVAEIKDTIQKIRVWLGTFDTAEEAARAYDEAACLLRGANTRTNFWPSSQSSSTTPALPSKITNLLLHRLKARNNSLAAAAAASSHHTQLTTGCHDDKKQHEEFRDDIGELPDTIFTDFLNDPDEYIPENYEILLTSSNDNYDNRNPLSSLPVKDDFDQLIAPDNLDNHDDHMASQCSSDDTNNEGAMEEDEFEEEGSSDMGVIDFGFIDELGSSCNFSPFEIAQEIASHELQEEVYNTEGDEPLTISEAMKRMKYERKYSASLYAFNGIPECLKLKLGLGRGIKSRERSKMQRTIKELDKKADEESKKDVEEEAVISSTTNIIDGELSLWSSLDLPTICYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHJ4</accession>
    <name>A0A103YHJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_012401</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the UPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHJ4"/>
    <dbReference type="STRING" id="59895.A0A103YHJ4"/>
    <dbReference type="Gramene" id="KVI09215">
        <property type="protein sequence ID" value="KVI09215"/>
        <property type="gene ID" value="Ccrd_012401"/>
    </dbReference>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="15">
        <location>
            <begin position="53"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="16">
        <location>
            <begin position="299"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI09215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="54981" checksum="4B3FBA65D2297031" modified="2016-04-13" version="1">MPEKTTSIDYVMEAASGPHFSGLHLNARFLPSSRSPSSSLLADSASALKQPFVIGVSGGTASGKTTVCDMIIQQLHDHRVVLVNQDSFYRGLTAEESERAHEYNFDHPVTADECLLILLNKKMPLFVDAFDTEQMLECVEKLKQGNPVHLPIYDFKNHRRCSESFRQVNASDVIILEGILVFHDQRVRDLMNMKIFVDTDADVRLARRIRRDTVERGRDVNSVLEQVSSSTFLKSLRYAKFVKPAFDDFVLPSKKYADVIIPRGGDNHVAIDLIVQHIRTKLGQHDLCKIYPNIYVIQTTFQIRGMHTLIRDREISKHDFVFYSDRLIRLVVEHGLGHLPFTEMQVVTPTGSVYSGVDFCKKLCGVSIVRSGESMENALRACCKGIKIGKILIHRDGDNGQQLIYEKLPKDISERHVLLLDPVLATGNSANQAIELLIQKGAPEGIHCVSKRFPSVKIVTSEIDVALNEEYRVIPGLGEFGDRYFGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHP2</accession>
    <name>A0A103YHP2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001066">
        <property type="protein sequence ID" value="KVI09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHP2"/>
    <dbReference type="STRING" id="59895.A0A103YHP2"/>
    <dbReference type="Gramene" id="KVI09296">
        <property type="protein sequence ID" value="KVI09296"/>
        <property type="gene ID" value="Ccrd_012326"/>
    </dbReference>
    <dbReference type="OMA" id="ERTHIWS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="11214" checksum="A923D5E440C4AD65" modified="2016-04-13" version="1" fragment="single">MSVENEEVVVLPRRKLSCTTSFDALWFCYSPVHQMQQYYRLGSLDNCSGKWNALVDCLKLKTKRSHEVEEILESREKDKSHIWCFRTPEEAASNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI95</accession>
    <name>A0A103YI95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI95"/>
    <dbReference type="STRING" id="59895.A0A103YI95"/>
    <dbReference type="Gramene" id="KVI09611">
        <property type="protein sequence ID" value="KVI09611"/>
        <property type="gene ID" value="Ccrd_011990"/>
    </dbReference>
    <dbReference type="OMA" id="DSCGQDM"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="828" mass="91040" checksum="FC1BD9BC9F064788" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIA6</accession>
    <name>A0A103YIA6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-like protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIA6"/>
    <dbReference type="Gramene" id="KVI09626">
        <property type="protein sequence ID" value="KVI09626"/>
        <property type="gene ID" value="Ccrd_011968"/>
    </dbReference>
    <dbReference type="OMA" id="GLNGFTM"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52565" checksum="D16F53C0940C3AD3" modified="2016-04-13" version="1">MPLDTSKIETLTPSQFITFTIPNSIPNPVKHYCYLRSPLLRVALLDSPKVTSNGDAPLIAAMIVPGHRESDWIFCTESGHFQLLLNFSNVSRLILIGNNPQPNSGASIYIRPPVTDTLDTEKLEDDLKPFVIALHPTECFQDGLPEPVFLTYEDDIMYRATIYRYVGPVVGEFLIEDVEVESKDDTNKVFRRRLRFKRTPNLIQSEIPLVPTISNAMGDLGLDLPSLRKMNEVEFRVDTDVLVQPYLTAMVSGLFLIVSLLDQRIKQGFIPRALCLGVGGGALLSFLNTRLKFKVVGVESDEVVLSIARQYFGLNSGNSIRLFVGEAIGYIAKIARRQRERSTRASQANTDWLDDKYDVLMVDLDSSDARAGTPPAEIIKKAIFQAVRLVLHDHGVFVINVIPSDDLFYMTLIQKLQDVFHKVYEIKVGTKNDSVLVATMSSVPNDHDNDLSIKLRCTISGAYVDSITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YID1</accession>
    <name>A0A103YID1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription repressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ovate family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional repressor that regulates multiple aspects of plant growth and development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YID1"/>
    <dbReference type="STRING" id="59895.A0A103YID1"/>
    <dbReference type="Gramene" id="KVI09639">
        <property type="protein sequence ID" value="KVI09639"/>
        <property type="gene ID" value="Ccrd_012011"/>
    </dbReference>
    <dbReference type="OMA" id="THHADCA"/>
    <dbReference type="OrthoDB" id="689823at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038933">
        <property type="entry name" value="Ovate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006458">
        <property type="entry name" value="Ovate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01568">
        <property type="entry name" value="A_thal_3678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057:SF26">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04844">
        <property type="entry name" value="Ovate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51754">
        <property type="entry name" value="OVATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OVATE" evidence="8">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="27289" checksum="4DE1EAE30AE9E2FE" modified="2016-04-13" version="1">MGKNMNLIPSLFLLNKHKELWLWPSCKHPKTRSFRLTTRDSSMSIHPNKESLPEADVELTTPDSCFTNSSESASISTESEKYFDNNECSSSSVETIVRGARSERLFFQPDATSSILETQGSGRQCTRVETGGGLPYKESVVMEMESDNPYGDFKKSMEEMVESHGLKDWDCLEELLRWYLRMNGKNNHEVIVGAFVDLLSGISGGGGSDHSTATFTSAASTFSSSSPSSDQIDRDKIKKEGKTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIG8</accession>
    <name>A0A103YIG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIG8"/>
    <dbReference type="STRING" id="59895.A0A103YIG8"/>
    <dbReference type="Gramene" id="KVI09637">
        <property type="protein sequence ID" value="KVI09637"/>
        <property type="gene ID" value="Ccrd_012019"/>
    </dbReference>
    <dbReference type="OMA" id="WEYPENI"/>
    <dbReference type="OrthoDB" id="2015260at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000034">
        <property type="entry name" value="Cupredoxin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF288">
        <property type="entry name" value="OS03G0648500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytocyanin" evidence="3">
        <location>
            <begin position="43"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17151" checksum="858E4149F2E6F9F6" modified="2016-04-13" version="1">MHSLLPWMRRPMVAHCRHRFSKTAILVPLALILVLFTAVVGGKKHIVGGSIWSIPPSKNFYNNWSSSQSFHPGDILHFEFESQMYNVLQVSYGQYARCEWEYPENIYSDGPALVSLTKTGELYFTCSIFNYCLLGLKMIVDVTPSPPPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJX9</accession>
    <name>A0A103YJX9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001018">
        <property type="protein sequence ID" value="KVI10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJX9"/>
    <dbReference type="STRING" id="59895.A0A103YJX9"/>
    <dbReference type="Gramene" id="KVI10506">
        <property type="protein sequence ID" value="KVI10506"/>
        <property type="gene ID" value="Ccrd_011099"/>
    </dbReference>
    <dbReference type="OMA" id="NPICVFF"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45277">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45277:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="294" mass="32835" checksum="6D2F6808F777D041" modified="2016-04-13" version="1">MGKTGRDWTQIYAIYGMDDWHTPIFLLIHAIVFSSSSLIFLLYFNWICYSFESIFPSVFSGSVARFAAGFTGSVTALSALCLFYAAGNMFYSSVALRWDMAQRMVSAVHDWSTVKTVLDVGCGRGILLNAVAMQLKKEGSSGRVVGLDRKNTTLSTLRTAGMEGVQEYVTCREGDARRLPFPDNYFDVVVSAGFVHKVGKEFGQKSAAASAERMRVVGEVVRVLKEGGIGVVWDLVHVPEYVLRLQELKMEEIRVSERVTAFMVSSHIVSFRKPSQHVLGPNEVRLDWRFNNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK22</accession>
    <name>A0A103YK22_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001018">
        <property type="protein sequence ID" value="KVI10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK22"/>
    <dbReference type="Gramene" id="KVI10493">
        <property type="protein sequence ID" value="KVI10493"/>
        <property type="gene ID" value="Ccrd_011083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="121" mass="13846" checksum="80B1953D23368704" modified="2016-04-13" version="1">MIIDQDALRAFFITFVLVASLSLLFVLILNFCTQWFENPGVIVQDTEMDIEMRIRAPPPTTTIHRVITSGVRQQAAVAADESHDHLPAMEEQEYKSSSRRDDKCVICLEEFKEMESIQNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKG8</accession>
    <name>A0A103YKG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_010857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001002">
        <property type="protein sequence ID" value="KVI10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKG8"/>
    <dbReference type="STRING" id="59895.A0A103YKG8"/>
    <dbReference type="Gramene" id="KVI10739">
        <property type="protein sequence ID" value="KVI10739"/>
        <property type="gene ID" value="Ccrd_010857"/>
    </dbReference>
    <dbReference type="OMA" id="YMFAGRV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043452">
        <property type="entry name" value="BZIP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952:SF463">
        <property type="entry name" value="ABSCISIC ACID-INSENSITIVE 5-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952">
        <property type="entry name" value="CAMP-RESPONSE ELEMENT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="381" mass="41618" checksum="86A380448D76EEB9" modified="2016-04-13" version="1">MGSFINFKNFGDTSQPELNGSRQMVSNSPLARQSSVYSLTFDELQNTLGGGGKDFGSMNMDELLKNIWSVEETQAVASTSNFGMDGSVQRQGSLTLLPRTLSQKTVDEVWRELLKSSSNGGFKDGELILEANLQPPQREMTLGEMTLEDFLMKARVVTENNEVQTNGRSGRSQNGAYFGDVSQQNVENGSFIFGFQNPNQNNGFQQQSAQNNRPTLNQITESKNGLNLQPKPQPQPQPPAQPLFPKQAALDFSAPLNGKLTSPGSKLTIPGTRVGKSEHPIKTSVVQASGIESGVMNIKSLGGLGTGSPRNLIPKSNLDTTPSPPYYAFGEGGLRGRKSSGTLEKVVERRRRRMIKNRESAARSRARKQASFLKQLTSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKX0</accession>
    <name>A0A103YKX0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_010684</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01000980">
        <property type="protein sequence ID" value="KVI10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKX0"/>
    <dbReference type="Gramene" id="KVI10915">
        <property type="protein sequence ID" value="KVI10915"/>
        <property type="gene ID" value="Ccrd_010684"/>
    </dbReference>
    <dbReference type="OMA" id="CYPICSF"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000187">
        <property type="entry name" value="E3 ubiquitin-protein ligase ATL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF19">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="333" mass="36841" checksum="4128E77A149542DB" modified="2016-04-13" version="1">MAASSRHRKFMEDTTKATAIDRYCTTQCNLPLNPTGVCVSTCHYICPSICRVIDSSPPPSSSSFSPANSPYPSLPITKHHHPPLSLPLRISLIFLFVTFSLFFLYTLCKLSVVWCRSRCHRTPPPPSPENYETNDNELVDHPIWYIRSVGLQSSVINAIAVVNFSKDDGVVEGSDCSVCLSEFETDETLRLLPNCKHAFHVSCIDTWLRSHTNCPLCRAAIVNNIVDSPSPELNTDEVGLMGEPDLGISLPVDDNRGEASESAELRIGETDEEDANSITKAEVLIIRRSVSVDDLEVSDHHEIPIQSVDGDLGIELVKIDQITDNNHPMRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM04</accession>
    <name>A0A103YM04_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000089">
        <property type="protein sequence ID" value="KVI11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI11534">
        <property type="protein sequence ID" value="KVI11534"/>
        <property type="gene ID" value="Ccrd_010055"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692153at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="24150" checksum="BCB9A7186B2ECAD4" modified="2016-04-13" version="1">MKPEQRPWTLHLQAKAKNFNFKFKATKYLPTCYNFLHFSIFLKISPLLIRVSSDNKPTTTSRSLKSKIIGVIEKVRSRPTKRKAFAAPKPLRIKRLKWVSCEGTICATTVVIGNLALLIQSISEKDTKGIIIHSLSXMLYILKPLRTSIRTNASKFMLISIIVMVGYPLWLHLHMKXHSSYAERIIVSRYIRKAWKWAASNGFLGVVAQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSY7</accession>
    <name>A0A118JSY7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSY7"/>
    <dbReference type="STRING" id="59895.A0A118JSY7"/>
    <dbReference type="Gramene" id="KVH90009">
        <property type="protein sequence ID" value="KVH90009"/>
        <property type="gene ID" value="Ccrd_007931"/>
    </dbReference>
    <dbReference type="OMA" id="EIFEMPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045277">
        <property type="entry name" value="DRE1A-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31839">
        <property type="entry name" value="DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31839:SF54">
        <property type="entry name" value="DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="237" mass="25789" checksum="5B07A7AB0CEDE16F" modified="2016-04-13" version="1">MSSQMDTPSPSSDPNSDGSHPSQSPNRTTRSDDGVILASAKPKKRAGRTKFKETRHPVYRGVRMRNPNKWVCEVREPNKKTRIWLGTYPTAEMAARAHDVAALALRGNHACLNFADSGWRLPVPATTDAAGIRKAAAEAAEAFRHVDMEVDNGEEKRDVVDGKSMVEGEATSATMEAEAVEVEVGSYMDEEAVFHMPRLISDMAAGMMLPPPSCLGGWSSDDVGSPHADVSLWDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTJ9</accession>
    <name>A0A118JTJ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005082">
        <property type="protein sequence ID" value="KVH91057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTJ9"/>
    <dbReference type="STRING" id="59895.A0A118JTJ9"/>
    <dbReference type="Gramene" id="KVH91057">
        <property type="protein sequence ID" value="KVH91057"/>
        <property type="gene ID" value="Ccrd_006928"/>
    </dbReference>
    <dbReference type="OMA" id="YQRSENW"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05381">
        <property type="entry name" value="CAP_PR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000004">
        <property type="entry name" value="CAP, cysteine-rich secretory protein, antigen 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159657" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="20447" checksum="B3B09169A98D0E39" modified="2016-04-13" version="1">MKQTNTFILSSLLVIFLASYKTNASVQEDNEFLDAHNKARRRAGMPPFTYDQTLAKYARKYALSHANDCALRHSNGPYGENLFWGSADGSRLKWTPKDAVYAWIREHKYYDKKTKSCIPGKKCGHYTQIMWRDTKKVGCALSYCNNKSTYVACEYDPPGNFEGLSPFERHDPFIYGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUU9</accession>
    <name>A0A118JUU9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004796">
        <property type="protein sequence ID" value="KVH93082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUU9"/>
    <dbReference type="STRING" id="59895.A0A118JUU9"/>
    <dbReference type="Gramene" id="KVH93082">
        <property type="protein sequence ID" value="KVH93082"/>
        <property type="gene ID" value="Ccrd_004875"/>
    </dbReference>
    <dbReference type="OMA" id="WVLQSDP"/>
    <dbReference type="OrthoDB" id="1928683at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36704:SF1">
        <property type="entry name" value="OS06G0239700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36704">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="258" mass="28358" checksum="932401966009AEDC" modified="2016-04-13" version="1">MSFIVGRLAAGKEGAYFLQESKHAVGRLVEKTNKPTVAAGNRPPATPIRETLDNEADILPEILKHNLPSRIFRPPSDSTLTTGSKWLLHPADDSNGASFVSRDAINPLRAYVSLPQVTFGPKRWQFPNAENSFAASTANELRNDKYTPMNSERLKAAAVGLSQIAKAFAAATAIVFGGATLTIGLAVSRLELHTTNDIRTKGKDIVQPKFESIKEHMAPLRTWAEGVSKKWHMEKDEDIKEKPMIKELSRMLGAKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWF3</accession>
    <name>A0A118JWF3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_003426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004551">
        <property type="protein sequence ID" value="KVH94507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWF3"/>
    <dbReference type="Gramene" id="KVH94507">
        <property type="protein sequence ID" value="KVH94507"/>
        <property type="gene ID" value="Ccrd_003426"/>
    </dbReference>
    <dbReference type="OMA" id="LFLEHYM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000385">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717:SF8">
        <property type="entry name" value="OS01G0301000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717">
        <property type="entry name" value="OS12G0527900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59686" checksum="3D72B5D9A0A764CD" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWH7</accession>
    <name>A0A118JWH7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GH3 auxin-responsive promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAA-amido conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWH7"/>
    <dbReference type="STRING" id="59895.A0A118JWH7"/>
    <dbReference type="Gramene" id="KVH95872">
        <property type="protein sequence ID" value="KVH95872"/>
        <property type="gene ID" value="Ccrd_002037"/>
    </dbReference>
    <dbReference type="OMA" id="TDGRQKY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF48">
        <property type="entry name" value="INDOLE-3-ACETIC ACID-AMIDO SYNTHETASE GH3.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH3 middle" evidence="3">
        <location>
            <begin position="391"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="4">
        <location>
            <begin position="493"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="628" mass="71240" checksum="8A56B18416ACDF48" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX20</accession>
    <name>A0A118JX20_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004274">
        <property type="protein sequence ID" value="KVH96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX20"/>
    <dbReference type="STRING" id="59895.A0A118JX20"/>
    <dbReference type="Gramene" id="KVH96534">
        <property type="protein sequence ID" value="KVH96534"/>
        <property type="gene ID" value="Ccrd_001380"/>
    </dbReference>
    <dbReference type="OMA" id="WWLRAIF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="143"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="548" mass="59801" checksum="E0989B641D0A9AFA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX49</accession>
    <name>A0A118JX49_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heavy metal-associated domain, HMA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004335">
        <property type="protein sequence ID" value="KVH96296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX49"/>
    <dbReference type="Gramene" id="KVH96296">
        <property type="protein sequence ID" value="KVH96296"/>
        <property type="gene ID" value="Ccrd_001617"/>
    </dbReference>
    <dbReference type="OMA" id="ESMEIMM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14000" checksum="4906CE6FC22671FB" modified="2016-04-13" version="1">MRRKKKNEEEEEEKSNKLIEVSTTLASVESLTFPLVQEVVLLADFGCKKCEDRVAGIVSRLNGEMESMEIMVMEKKVIFTFTSKYSREIKTCGKKLEVATIYKHMAKKIFNVKRFLRALNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXF7</accession>
    <name>A0A118JXF7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_000983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004074">
        <property type="protein sequence ID" value="KVH96924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXF7"/>
    <dbReference type="STRING" id="59895.A0A118JXF7"/>
    <dbReference type="Gramene" id="KVH96924">
        <property type="protein sequence ID" value="KVH96924"/>
        <property type="gene ID" value="Ccrd_000983"/>
    </dbReference>
    <dbReference type="OMA" id="DSDCYFT"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001070">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At1g11630, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF9">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="45995" checksum="FA761BAA8CB07A6E" modified="2016-04-13" version="1">MASVARFRILNSCNRRILFSIYQIQARHFSSILNPDSTTPLSSKEKSRAALSLLKFEKNPERIIEICRAASLTPESHLDRLAFSIAIKKLTEMNYFEGIRNFIDELLKTRPDLNNDKFISDAIVYYGQAGLLNNAFQLFDKMPQLGAAQNAKSLNALLFSCMLAKKYDEVKRVYLEFPGKYGVKPNLDTYNTVIKSFCESGSASSCYSVTAEMVRKKCKPNAASFGTMIAGFYKEEKFEEVGKVLEMMKKHEVPVGIGTYNIRIQSLCKLKKTEEAKALLDGLLSRGMKPNSVTYSHLIHGYCKEGILDEAKDLFRKMIGGGFKPDSDCYFTLVHYLCKGGDFKTALEVCKKSIEKDWVPNFSTMKLLVEGLANGSEVNEAKELIGQMKEKFPKNAGIWDEVEENLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXS5</accession>
    <name>A0A118JXS5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport and Golgi organization protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004269">
        <property type="protein sequence ID" value="KVH96567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXS5"/>
    <dbReference type="Gramene" id="KVH96567">
        <property type="protein sequence ID" value="KVH96567"/>
        <property type="gene ID" value="Ccrd_001349"/>
    </dbReference>
    <dbReference type="OMA" id="FAWRPGH"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF16">
        <property type="entry name" value="TRANSPORT_GOLGI ORGANIZATION-LIKE PROTEIN (DUF833)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30379" checksum="A4315261453402B4" modified="2016-04-13" version="1">MCISVFLWQAHPLYPFLLLLNRDEYHDRPTDPLNWWEGGKILGGRDVTAGGTWLASSRGGKVAFVTNVREVKLISNAKSRGDLPVRFLKSNKNPMEFAEEIAKEADQYNGFNLLVADLLSMDMVYVTNRLKGDNCYMTTVSPGVHVLSNASLDTPWPKAQRLEHGFRDLLDQYCEGEIPINEMVDKLMGNTVKDEISMLPEVYNPEFEYQLSSVFVDTVTPKGRYGTRSTSALAVKASDEVFFYEKHLENDSWKEQTATYMIEKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ60</accession>
    <name>A0A118JZ60_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-affinity nitrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ60"/>
    <dbReference type="STRING" id="59895.A0A118JZ60"/>
    <dbReference type="Gramene" id="KVH98962">
        <property type="protein sequence ID" value="KVH98962"/>
        <property type="gene ID" value="Ccrd_022809"/>
    </dbReference>
    <dbReference type="OMA" id="IVYLMIQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010167">
        <property type="term" value="P:response to nitrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016605">
        <property type="entry name" value="Transptr_NO3_Nar2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806:SF8">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16974">
        <property type="entry name" value="NAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26220" checksum="E857234A601A686B" modified="2016-04-13" version="1" fragment="single">GSIYSNSEVCESWFRFLLIESTTVSVLSFKKVIIISMEFCGGFVVGYLLFSCFAAACYGVTFSSLQKTLIVTASSPKGHDQLTVKWAFDQTFPAGTDSTYKTIRVKLCYAPLSQVDKPWRKSVDDLNKDKTCQHKIVAKPYTPSNNSFTWTIETDVPKATYFVRAYALDERQVQVGYGQNTDASKVTDLFDIRAISGRHVSLDIASVCFSVFSVVSLAVFFYMEKRKGNVTQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZH3</accession>
    <name>A0A118JZH3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003450">
        <property type="protein sequence ID" value="KVH99547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZH3"/>
    <dbReference type="STRING" id="59895.A0A118JZH3"/>
    <dbReference type="Gramene" id="KVH99547">
        <property type="protein sequence ID" value="KVH99547"/>
        <property type="gene ID" value="Ccrd_022217"/>
    </dbReference>
    <dbReference type="OMA" id="LCECNIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol transfer protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF6">
        <property type="entry name" value="F16L1.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="153"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="378" mass="43885" checksum="C3C249AA005FD03D" modified="2016-04-13" version="1">MWDNLWDQSPYCVESRNHLQSPNCFPPGNFNSLLSLNFSLLLLFQILVKSPERKKDLFQAMNPQLNKPNSNLLLTPEDEQKMITEVRETIKKHKSIKKMRECRPDEFSRFCCDGSISRYLRARNWNVKKAVKMLETSLIWRMNYKPEEICWEHVAAEAETGKIYRSSYRDKNGRAVLVLRPRFQNSNSTRSQIKYLVYCMENAILNSPSDQEQMIWLIDFQGFNLSNISIKSTKETAHILQDHYPERLGLAILYNPPKFFEPFYKVVKPFLEPKTANKVKFVYADDPNTKTIMDNLFCMDELESAFGGKDEENFDIMKYAEKMKEDDAKRIALHRGESGSETASSMPIANPDSDTEKLSDTNSIMTNVDEARKVSCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0D6</accession>
    <name>A0A118K0D6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_020794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003162">
        <property type="protein sequence ID" value="KVI00943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0D6"/>
    <dbReference type="STRING" id="59895.A0A118K0D6"/>
    <dbReference type="Gramene" id="KVI00943">
        <property type="protein sequence ID" value="KVI00943"/>
        <property type="gene ID" value="Ccrd_020794"/>
    </dbReference>
    <dbReference type="OMA" id="NNNFQWP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46084">
        <property type="entry name" value="PROTEIN MALE DISCOVERER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46084:SF1">
        <property type="entry name" value="PROTEIN MALE DISCOVERER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="11">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI00943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="574" mass="63534" checksum="A66C48C81F39841A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0F4</accession>
    <name>A0A118K0F4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase NAALADL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">N-acetylated-alpha-linked acidic dipeptidase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_020509</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0F4"/>
    <dbReference type="STRING" id="59895.A0A118K0F4"/>
    <dbReference type="Gramene" id="KVI01217">
        <property type="protein sequence ID" value="KVI01217"/>
        <property type="gene ID" value="Ccrd_020509"/>
    </dbReference>
    <dbReference type="OMA" id="LWNVIGT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="335"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="558"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI01217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="683" mass="75413" checksum="9790533A44480655" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K101</accession>
    <name>A0A118K101_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_019605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002663">
        <property type="protein sequence ID" value="KVI02117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K101"/>
    <dbReference type="STRING" id="59895.A0A118K101"/>
    <dbReference type="Gramene" id="KVI02117">
        <property type="protein sequence ID" value="KVI02117"/>
        <property type="gene ID" value="Ccrd_019605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="3 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11 13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI02117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="15436" checksum="65179B9A0F4F9F56" modified="2016-04-13" version="1">MLGAAGAIAPHPSRNRPPMVPDGCHPPSRHLQLLGRPLHPIRDGNSTHGFCRAPKIPRLVLTQAPWKAILLGTSETVFGIRDLAYPGGPFFNPLGFGKDEKSMEELKLKEIKKGRLAICWVLLHSGSGHRGWTIPEPFGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2L9</accession>
    <name>A0A118K2L9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage/polyadenylation specificity factor, A subunit, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002002">
        <property type="protein sequence ID" value="KVI04543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K2L9"/>
    <dbReference type="Gramene" id="KVI04543">
        <property type="protein sequence ID" value="KVI04543"/>
        <property type="gene ID" value="Ccrd_017140"/>
    </dbReference>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000402">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="105"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="578"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1451" mass="158729" checksum="060D2EAB9B490E99" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2P5</accession>
    <name>A0A118K2P5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001939">
        <property type="protein sequence ID" value="KVI04683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2P5"/>
    <dbReference type="STRING" id="59895.A0A118K2P5"/>
    <dbReference type="Gramene" id="KVI04683">
        <property type="protein sequence ID" value="KVI04683"/>
        <property type="gene ID" value="Ccrd_016994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl-tRNA synthetase catalytic core" evidence="7">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="136" mass="15551" checksum="AED1457A45DEAA91" modified="2016-04-13" version="1">MQKFAFGNNNNAMILWSKIKGKGTEFRGPQLVRQSIQKMLKDGIETWAPKLPVKRAIVDFSSPNIAKELHVGHLRSPIIGDTLARMLEYSKVEVLRRNHVGDWGTWVHAIDLHVYFFLVFQSLFSSHLCVVYSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3H6</accession>
    <name>A0A118K3H6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3H6"/>
    <dbReference type="STRING" id="59895.A0A118K3H6"/>
    <dbReference type="Gramene" id="KVI05988">
        <property type="protein sequence ID" value="KVI05988"/>
        <property type="gene ID" value="Ccrd_015680"/>
    </dbReference>
    <dbReference type="OMA" id="FQNFVQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="193"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="284"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="664" mass="73248" checksum="F49E82D3105DFA2A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K448</accession>
    <name>A0A118K448_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001541">
        <property type="protein sequence ID" value="KVI06917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K448"/>
    <dbReference type="STRING" id="59895.A0A118K448"/>
    <dbReference type="Gramene" id="KVI06917">
        <property type="protein sequence ID" value="KVI06917"/>
        <property type="gene ID" value="Ccrd_014727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="93" mass="10271" checksum="3125C0914C5E4C4B" modified="2016-04-13" version="1">MRGRRGNDDAGRRGEEGDRRWRLWRSPAMETREGDAQDGSSTGGPSTSTSIAAVSEDGNSEIDEDDDDLDMDELNELEASLSKTSIQIQEPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K490</accession>
    <name>A0A118K490_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001513">
        <property type="protein sequence ID" value="KVI07185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K490"/>
    <dbReference type="STRING" id="59895.A0A118K490"/>
    <dbReference type="Gramene" id="KVI07185">
        <property type="protein sequence ID" value="KVI07185"/>
        <property type="gene ID" value="Ccrd_014454"/>
    </dbReference>
    <dbReference type="OMA" id="CCTFKED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="83" mass="9838" checksum="1A40AEA271D2E001" modified="2016-04-13" version="1">MKKMLKNCFCCTFKEDQDPKISPQKNRDYPWNMYTLKELVHATNSFHNDNKIGEGGFGSVYWGRTSKGAEAIHYPYSFRYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4H4</accession>
    <name>A0A118K4H4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4H4"/>
    <dbReference type="STRING" id="59895.A0A118K4H4"/>
    <dbReference type="Gramene" id="KVI07563">
        <property type="protein sequence ID" value="KVI07563"/>
        <property type="gene ID" value="Ccrd_014098"/>
    </dbReference>
    <dbReference type="OMA" id="CRAYVMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904278">
        <property type="term" value="P:positive regulation of wax biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016441">
        <property type="term" value="P:post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1186" mass="133811" checksum="CCE6E2B84EADD5FD" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4N8</accession>
    <name>A0A118K4N8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER lumen protein retaining receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_013853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001488">
        <property type="protein sequence ID" value="KVI07787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4N8"/>
    <dbReference type="STRING" id="59895.A0A118K4N8"/>
    <dbReference type="Gramene" id="KVI07787">
        <property type="protein sequence ID" value="KVI07787"/>
        <property type="gene ID" value="Ccrd_013853"/>
    </dbReference>
    <dbReference type="OMA" id="IHPTTQH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="30922" checksum="70390CE765409E6E" modified="2016-04-13" version="1">MKGTTKRPIQVVRTWVRRQPPKVKVFLAFVCAIAALIFIRMVVYDHDNLFIAAEAVHALGISVLIYKLATEKTCAGLSLKSQELTAIFLGSRLYCSFVMEYDVHTLLDLATLAATVWVVYMMRFNLNASYMHEKDNVANYYVVIPCALLSLLIHPTTQHYIVNRILWAFCVYLEAVSVLPQLRVMQNTKIVEPFTAHYVFALGVARFLSCAHWILQVLDTRGRLLTALGYGLWPSMVLLSEIVQTFILADFCYYYVQSVMGGQLVLRLPSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5H5</accession>
    <name>A0A118K5H5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_012473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5H5"/>
    <dbReference type="Gramene" id="KVI09123">
        <property type="protein sequence ID" value="KVI09123"/>
        <property type="gene ID" value="Ccrd_012473"/>
    </dbReference>
    <dbReference type="OMA" id="WIQIWNN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="504" mass="56019" checksum="239CDC51D5CCAEEF" modified="2016-04-13" version="1">MAGGQRFGSLNKPCVLLIVIAGIERFVFKGVASNLVIYLTDVMDMSNSAAARTVNSWCGFTSMLPLLVAPLVDSYWNPVNRGNSSSSSSMFLSLYLISLGQGGYNPSLQAFGADQIDTDDELPTAKSDQKSDKKSMFFQWWYFGICSGSLLGVSIMPNIQDTVGWGLGFAMPAMAMVISMVMFSCGSRFYSYSHDQSNDFKSLEKVVQALKCSVSKFVHHKTQEKSTIIELELEDKPLCLKGENGTESLGDQKSNNSNRLVKIAKVIIRLLPIWTTLLMFAVIFQLPVTFFIKQGMTMKRNIGENYKIPPATLQSAITISIILLMPFYDTIFIPFTRFILRNEKGITTMQRIAIGMFLSVIAMIFAATVEMKRLETSTESESATLSIFWLLPQYILLGISDIFTVVGMQEFFYSAVPNGMRTMGIALYTSVFGVGSFLSALMVYLVEYFTSSAGGKGNWFSDDMKEARLDKYYWLLAGTSVVSLVVFVVLCRFQKTSPVDVEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5J3</accession>
    <name>A0A118K5J3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5J3"/>
    <dbReference type="STRING" id="59895.A0A118K5J3"/>
    <dbReference type="Gramene" id="KVI09193">
        <property type="protein sequence ID" value="KVI09193"/>
        <property type="gene ID" value="Ccrd_012444"/>
    </dbReference>
    <dbReference type="OMA" id="VVWFSHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000198">
        <property type="entry name" value="High affinity nitrate transporter 2.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000053">
        <property type="entry name" value="Nitrate transporter 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="33"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="452" mass="48747" checksum="C6C089523DAB6047" modified="2016-04-13" version="1">MEMEPQKFSIAVDADHKATQFRPLSLSSPHMRAFHLAWLSLFSCFFSTFSIPPLLPIIRQDLNLSPTDVGTAGIAAFAGSIISRLAMGPACDLFGPRLASATLSLVTAPILLSAAFISSPLSFILLRFFVGFSLANFVANQFWMSSMFSGCTVGLANGVSAGWANVGSGLTQLVMPVIFSILNTNFNLSQSTSWRAAFVVPAIFQAMMALMVLAYGQDLPDGKYRKHKKLPNKDSNDTGVFLNGITNYRGWVLGLTYGFCFGVELTMDNIIAEYFYDRFGVNMETAGVIAASFGFANWVSRPTGGVVSDKLGRRFGMKGRLWGLWVVQTVAGLLCIWLGRVDSLWGSVVVMCGFSFFVQAASGLTFGVVPFVSKRSMGVISGMTGSGGTVGAVVTQLLLFSGSTKFSTETGISLMGVMMIVSTLTLTTIHFPQWGGMFCAPSFDHQDYHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5R9</accession>
    <name>A0A118K5R9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001058">
        <property type="protein sequence ID" value="KVI09508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5R9"/>
    <dbReference type="Gramene" id="KVI09508">
        <property type="protein sequence ID" value="KVI09508"/>
        <property type="gene ID" value="Ccrd_012117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="104" mass="12032" checksum="EAE78C96AD39E837" modified="2016-04-13" version="1">MKQGEDACCPLLHAALDYSICSSSNVHNLFCFDRVSLNVTEDEFSPPTFDVISLRRLTVVSITPDMNQSAWKGFPMFISYRTRLKHRPSERLVCMPYLRYMTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5U4</accession>
    <name>A0A118K5U4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5U4"/>
    <dbReference type="STRING" id="59895.A0A118K5U4"/>
    <dbReference type="Gramene" id="KVI09618">
        <property type="protein sequence ID" value="KVI09618"/>
        <property type="gene ID" value="Ccrd_011997"/>
    </dbReference>
    <dbReference type="OMA" id="FANARQE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="240" mass="26748" checksum="DE15819D36D99DD2" modified="2016-04-13" version="1">MTLTPEQHQISIFTHDHLRKFRVGGGLGVCSQTVEVGYVRKRKRSPSVEAPHMCEDGYRLIVTLICQFDTNMGTPSFLWNVCKSSFACGLIGLTISDRIASIVPVQGFSMSPTFNPYNSRPLGLFTDDHVLVEKHCLKDYKFSHGDVVVFCSPSSYKEKHIKRITAMPGDWISVPYSYDAVKIPEGHCWVEGDNPTNSLDSRSFGPIPLGLIRGRVTHILWPPQRVGKIDRKLPGGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6I3</accession>
    <name>A0A118K6I3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001002">
        <property type="protein sequence ID" value="KVI10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6I3"/>
    <dbReference type="STRING" id="59895.A0A118K6I3"/>
    <dbReference type="Gramene" id="KVI10740">
        <property type="protein sequence ID" value="KVI10740"/>
        <property type="gene ID" value="Ccrd_010858"/>
    </dbReference>
    <dbReference type="OMA" id="YHTINKQ"/>
    <dbReference type="OrthoDB" id="641808at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="18401" checksum="74A7BA035A0E0D4A" modified="2016-04-13" version="1">MADSKQPPHLLFKQRSWSPDIHRDKEWQKLKFKQLRRDRHRRCKSIDADIDVTDDDVKELKACFDLGFGFDPSHDLDPKLTQAFPALELYAAVNRQYNNRLLSRSSSSLSSDSSSSSSSLTTAIIDPNDDPQKVKTKLKQWAQVVSCSILDASPQPITKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6X5</accession>
    <name>A0A118K6X5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor G, III-V domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000326">
        <property type="protein sequence ID" value="KVI11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6X5"/>
    <dbReference type="STRING" id="59895.A0A118K6X5"/>
    <dbReference type="Gramene" id="KVI11342">
        <property type="protein sequence ID" value="KVI11342"/>
        <property type="gene ID" value="Ccrd_010243"/>
    </dbReference>
    <dbReference type="OMA" id="MEVYKGQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16263">
        <property type="entry name" value="BipA_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03691">
        <property type="entry name" value="BipA_TypA_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01891">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000016">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000002">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000003">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000055">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="entry name" value="bipa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048876">
        <property type="entry name" value="BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047041">
        <property type="entry name" value="BipA_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047042">
        <property type="entry name" value="BipA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047043">
        <property type="entry name" value="BipA_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21018">
        <property type="entry name" value="BipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="86"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="640" mass="71259" checksum="C1219CF4F620874F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K759</accession>
    <name>A0A118K759_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000045">
        <property type="protein sequence ID" value="KVI11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K759"/>
    <dbReference type="STRING" id="59895.A0A118K759"/>
    <dbReference type="Gramene" id="KVI11760">
        <property type="protein sequence ID" value="KVI11760"/>
        <property type="gene ID" value="Ccrd_009814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080143">
        <property type="term" value="P:regulation of amino acid export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040359">
        <property type="entry name" value="GDU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33228:SF77">
        <property type="entry name" value="PROTEIN GLUTAMINE DUMPER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33228">
        <property type="entry name" value="PROTEIN GLUTAMINE DUMPER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="581" mass="62348" checksum="9BB369C63AC7CA39" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBC5</accession>
    <name>A0A124SBC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBC5"/>
    <dbReference type="STRING" id="59895.A0A124SBC5"/>
    <dbReference type="Gramene" id="KVH90220">
        <property type="protein sequence ID" value="KVH90220"/>
        <property type="gene ID" value="Ccrd_007815"/>
    </dbReference>
    <dbReference type="OMA" id="GMTNNYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000002">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF242">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
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            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="422" mass="46980" checksum="7DD3A0ACC6CDE13B" modified="2016-04-13" version="1">MSSLSSFERGSRMDLIATKSEASLRRRNSFSGGSDASSAVVKRRRRCPSMLALNDHKSSGAKENQLPAPTTPLLDHSNGVVTTATTTPTTPTTVKRSSKFRGVSSLQVLIYRHRWTGRYEAHLWDKGSWNATQKKKGKQGAYDEEESAARAYDLAAIKYWGTTTFTNFPISKMTTLPLLNRRSSGFSRGVSKYRGVARHHHNGRWEARIGRVFGNKYLYLGTYSTQEEAAHAYDIAAIEYRGINAVTNFDLSTYIRWLRSGSNSAAATSQSQDQTLPPAITAPHHVVEEPRFPFGSSSLQLGINNASQDQQLLDTKTLMADTDSSSSAPSALSLLLRSSMFKELVEKNLNAGNDEEQETKVVMKSEGNEFRGMFFNGMCPSKVGMELNEDEDEDEKNELPLFRNPNQSLWNGSRNINKSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC27</accession>
    <name>A0A124SC27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC27"/>
    <dbReference type="Gramene" id="KVH92456">
        <property type="protein sequence ID" value="KVH92456"/>
        <property type="gene ID" value="Ccrd_005518"/>
    </dbReference>
    <dbReference type="OMA" id="GTWLDFP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923:SF4">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="516" mass="56949" checksum="0BF90A9292632DA2" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCJ4</accession>
    <name>A0A124SCJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_003920</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004577">
        <property type="protein sequence ID" value="KVH94000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCJ4"/>
    <dbReference type="Gramene" id="KVH94000">
        <property type="protein sequence ID" value="KVH94000"/>
        <property type="gene ID" value="Ccrd_003920"/>
    </dbReference>
    <dbReference type="OMA" id="DWYTSQL"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000005">
        <property type="entry name" value="subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176137" evidence="12">
        <location>
            <begin position="24"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="15">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="133"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="14">
        <location>
            <begin position="383"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="16">
        <location>
            <begin position="658"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH94000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="758" mass="80904" checksum="D1F79BF62EF32571" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEJ4</accession>
    <name>A0A124SEJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L34Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003393">
        <property type="protein sequence ID" value="KVI00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEJ4"/>
    <dbReference type="STRING" id="59895.A0A124SEJ4"/>
    <dbReference type="Gramene" id="KVI00286">
        <property type="protein sequence ID" value="KVI00286"/>
        <property type="gene ID" value="Ccrd_021481"/>
    </dbReference>
    <dbReference type="OMA" id="TARMEVW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996">
        <property type="entry name" value="OS05G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996:SF6">
        <property type="entry name" value="OS05G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="263" mass="29089" checksum="2D5C044E7988B7C3" modified="2016-04-13" version="1" fragment="single">LRSILEINASSSFLPAASLTSSISIAPFRTNFEMRLPMVDCRSLIEFCRAFEQHKNMTPTNSNNHSRNNKKFNNASNSVNPLSHPFCDRSPFAALDILMLILVLGALGFLIIPYINIIYREAIEILPLVCDVIQEVISDAPIAYVVGVVAAFSGVIATIAAWEILEVKSRKCGKPNCKGLRKAVEFDIQLESEECVKYLSSGGTADNDVKPLELGQDHKELEAELKKMAPVNGRTVLIFRAPCGCPAGRLEVWGSKRIRRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFI1</accession>
    <name>A0A124SFI1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_018389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002374">
        <property type="protein sequence ID" value="KVI03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFI1"/>
    <dbReference type="Gramene" id="KVI03313">
        <property type="protein sequence ID" value="KVI03313"/>
        <property type="gene ID" value="Ccrd_018389"/>
    </dbReference>
    <dbReference type="OMA" id="WREQVEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="226"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="375" mass="42534" checksum="5D3CE3196CCB404D" modified="2016-04-13" version="1">MEAKAKTLGGSLLVPSVQELAKEPLVKVPTRYVRHHHGFSVASSVSAVPIIDMQRLASKDSSDHELEKLHFACKDWGFFQMINHGVSCSLLEKVKEETQELFKLPMAEKKKYWQEAGDIQGFGQAFVVSEEQKLDWSDTFFLITLPHHIRNPNLFPTLPLPLRSLTLPSFSISISLCKCKFLVVKHKDTLEEYSREVKNISLKTLNFMAKCLRMEVEDMKALFEEGIQSVRMNYYPPCPQPEQVMGLTPHSDCHGITFLLQINDVEGLQIKKDGAWMQVKPLPNAFIVNLGDTLEIVTNGIYKSVEHRAVVNSEKERLSIATFLGPNLDGDMGPAPSLITSETRPRFTRISVADYNNNFFSRELKGKSNLEQYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH55</accession>
    <name>A0A124SH55_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_013139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001112">
        <property type="protein sequence ID" value="KVI08491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH55"/>
    <dbReference type="STRING" id="59895.A0A124SH55"/>
    <dbReference type="Gramene" id="KVI08491">
        <property type="protein sequence ID" value="KVI08491"/>
        <property type="gene ID" value="Ccrd_013139"/>
    </dbReference>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034286">
        <property type="term" value="P:response to maltose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000023">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI08491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="36336" checksum="60F676579EE0D478" modified="2016-04-13" version="1">MATATAPSRSFLQVAATEEAVAPPLRVVQIEGLVILKIIKHCTEFSPALVTGQLLGLDVGSVLEVTNCFPFPIREEDEEIEAEGANYQLEMMRCLREVNVDNNTVGWYQSTLLGSFQTVELIETFMNYQENIRRCVCIIYDPSKSNQGVLALKALKLSDSFMELYRNNDFNGEKLREKNLTWVDIFEEIPSDYDRLQLSTIPVMERNMEFLIECMDDLSMEQQKFQFYYRNLSRQQAQQQTWLQKRRAENMARKAAGEDPLPEEDPSNPIFKPLPEPSRLDSFLITNQVSNYCNQINSVAGQSFSRLYLMKALHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH77</accession>
    <name>A0A124SH77_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanobacterial aminoacyl-tRNA synthetase CAAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001099">
        <property type="protein sequence ID" value="KVI08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH77"/>
    <dbReference type="STRING" id="59895.A0A124SH77"/>
    <dbReference type="Gramene" id="KVI08671">
        <property type="protein sequence ID" value="KVI08671"/>
        <property type="gene ID" value="Ccrd_012962"/>
    </dbReference>
    <dbReference type="OMA" id="TSTRCIP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025564">
        <property type="entry name" value="CAAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033344">
        <property type="entry name" value="CURT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222:SF2">
        <property type="entry name" value="PROTEIN CURVATURE THYLAKOID 1D, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14159">
        <property type="entry name" value="CAAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanobacterial aminoacyl-tRNA synthetase CAAD" evidence="4">
        <location>
            <begin position="201"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="31673" checksum="322E133F5784DD04" modified="2016-04-13" version="1">MELCTSTRCIPNHLTPFTPYRPTLQWRCSLPLKFHPIARNYPGSRYYSYFSIKATSSEETSSGANQYVKEEPDVINYSSIKATTPEETSNETNQYVKDEPESEVTDDEVQAEEKSGFGGFGLFKDDAETNDQFPQFDFLNKLKVEVMMDLMDCPCLLDHYAFDGYLDSNLLQQDGLPSSCPCPLLSRVLAQLLLMEPTLDFEDSFSIALLSVGGIAALWLTASIVGAIDNIPLFPKLMEVVGLGYTIWFSSRYLLFKRNRDELASKIEEIKQQVLGGKVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH92</accession>
    <name>A0A124SH92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001087">
        <property type="protein sequence ID" value="KVI08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH92"/>
    <dbReference type="STRING" id="59895.A0A124SH92"/>
    <dbReference type="Gramene" id="KVI08838">
        <property type="protein sequence ID" value="KVI08838"/>
        <property type="gene ID" value="Ccrd_012793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="COV-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876:SF20">
        <property type="entry name" value="PROTEIN LIKE COV 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="17749" checksum="C90D0F4746E87F6E" modified="2016-04-13" version="1">MGTREKDRDLERLIPVTRSGISEIDGDSNSSSPAESPPGASSSSSHQSGKEAVVKVVRSWASKKFMTGWHPSVGEYALGFITSTVILRKNTGAEELCCIYVPTNHLYLGDIVLVNSKDVMKPNISVREGIEIVISGGMSIPNILTTMDSQSILAPRSGKYVVPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHJ4</accession>
    <name>A0A124SHJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHJ4"/>
    <dbReference type="Gramene" id="KVI09736">
        <property type="protein sequence ID" value="KVI09736"/>
        <property type="gene ID" value="Ccrd_011862"/>
    </dbReference>
    <dbReference type="OMA" id="KEISAHA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000530">
        <property type="entry name" value="ABC transporter G family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF21">
        <property type="entry name" value="PLEIOTROPIC DRUG RESISTANCE PROTEIN PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="92"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI09736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="731" mass="81004" checksum="374A9CE47A9ECF27" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103LW23</accession>
    <name>A0A103LW23_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Peroxidase</fullName>
            <ecNumber evidence="5 20">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_026656</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17 20">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 20">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="17 20">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 20">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="5 20"/>
    <dbReference type="EMBL" id="LEKV01008987">
        <property type="protein sequence ID" value="KVF83137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103LW23"/>
    <dbReference type="Gramene" id="KVF83137">
        <property type="protein sequence ID" value="KVF83137"/>
        <property type="gene ID" value="Ccrd_026656"/>
    </dbReference>
    <dbReference type="OMA" id="WVDFGNS"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000006">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000009">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF126">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 20" id="KW-0349">Heme</keyword>
    <keyword evidence="20" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="12 17 20" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 20 22" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989323" description="Peroxidase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="21">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="124"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVF83137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="35387" checksum="0476AD443814DBFB" modified="2016-04-13" version="1">MEMNIMSFLSLLIFLIFSIVTVSCDTPLSPSYYDQVCPEALPTIKRVVEEAIANERRMGASLLRLHFHDCFVNGCDASVLLDQTLTIDSEKNAAANLNSARGFEVIDKIKFEVDKVCHRPVVSCADILTVAARDSVVALGGPSWDVKLGRRDSTTASREAADANLPNPFMDLPALIENXENQGLDEDDLVVLSGAHTLGSAQCHTFRARIYDQTNIDPAFAHHLQTICPQVGGDMRLAPLDPTPNSFDNRYFTNLVSKKGLLRSDQALFTGGETNEIVEKYNENQNKFSMDFTKSMIKMGNIKPLTGERGQIRTDCKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103MLL5</accession>
    <name>A0A103MLL5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase, superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008817">
        <property type="protein sequence ID" value="KVF96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103MLL5"/>
    <dbReference type="STRING" id="59895.A0A103MLL5"/>
    <dbReference type="Gramene" id="KVF96503">
        <property type="protein sequence ID" value="KVF96503"/>
        <property type="gene ID" value="Ccrd_026607"/>
    </dbReference>
    <dbReference type="OMA" id="CADDSMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476">
        <property type="entry name" value="CHITINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476:SF8">
        <property type="entry name" value="CHITINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="16054" checksum="A18ADAB5A9FEAD34" modified="2016-04-13" version="1">MFYMTQLVGGQLITILKKSQTIKFASIAPYEDNGPLQSHYLALWKKYGYVIDYVYAYDKLSVSPFIYHFNHQQDSSYVGCQLLASFISKGNLDLPPNDGFFEACRELKRQGKLGGIFVWSLMNQKPLVLNMNKNLRLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VX70</accession>
    <name>A0A103VX70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-plastoquinone oxidoreductase, chain 5 subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006651">
        <property type="protein sequence ID" value="KVH61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103VX70"/>
    <dbReference type="Gramene" id="KVH61724">
        <property type="protein sequence ID" value="KVH61724"/>
        <property type="gene ID" value="Ccrd_025653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056777">
        <property type="entry name" value="Ycf2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05695">
        <property type="entry name" value="Ycf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01435">
        <property type="entry name" value="NPOXDRDTASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ycf2 N-terminal" evidence="12">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="33392" checksum="B724294085675ECB" modified="2016-04-13" version="1" fragment="single">MGFTIKLTLIWSWIITNDFSLEFGYLINPLTSIMSILITTVGILVLIYSDNYMSHDHGYLRFFVYMSFFSIISFDSSILTRSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQXFLTIAWEQVHLRRVDRSSIRNCIGGKNPPESDFLRNVSRENLIWLDNVWLVNKDRFFRKVRNVSSNIQYDSTRSSFVQLRDSSQLKGSSDQSRDHFDSISNEDSEYHTFQRCLEDGPDXAERRPGSGFPTGGGGQETAISRHITTYRQHRQDLGRQPDWESEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB00</accession>
    <name>A0A103XB00_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006277">
        <property type="protein sequence ID" value="KVH87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB00"/>
    <dbReference type="STRING" id="59895.A0A103XB00"/>
    <dbReference type="Gramene" id="KVH87394">
        <property type="protein sequence ID" value="KVH87394"/>
        <property type="gene ID" value="Ccrd_025375"/>
    </dbReference>
    <dbReference type="OMA" id="FSFIYYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF33">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NET" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16424" checksum="3A15167599061718" modified="2016-04-13" version="1" fragment="single">MCSPHGHFFRRLQPENGNQTIEDKIEIDIDTLSNDTLFKLRKLLDDYLVDKQKNMAKAETCEIELHNESGFSNSSMEACKANDANEEDVDIGGNDLPISSFPPIEIEKDTAVRNSKCSSSSSSSSDSGSSSSESDLRVPELKLPFYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCJ1</accession>
    <name>A0A103XCJ1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005508">
        <property type="protein sequence ID" value="KVH88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCJ1"/>
    <dbReference type="STRING" id="59895.A0A103XCJ1"/>
    <dbReference type="Gramene" id="KVH88220">
        <property type="protein sequence ID" value="KVH88220"/>
        <property type="gene ID" value="Ccrd_024390"/>
    </dbReference>
    <dbReference type="OMA" id="AILQCML"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="178" mass="19834" checksum="AAD3543F94A04028" modified="2016-04-13" version="1">MFTNGQRQEERTGKYGTPRVQYLQELVAQFQNASNEELKEKIVANLANFAYDPYNYTFLRQLNVLELFLDCITEPNEKLIEFGAGGICNSCVDPANAAVITKCDGVPLLIQCLSSPVKNTVNYALGALYYLCNVSTKEAILRPEVVNIIRRYAAAGGVSISFSNLARSFLDKHVPENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCR1</accession>
    <name>A0A103XCR1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005452">
        <property type="protein sequence ID" value="KVH88310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH88310">
        <property type="protein sequence ID" value="KVH88310"/>
        <property type="gene ID" value="Ccrd_024165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF585">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="655" mass="74342" checksum="631C9B440EF4AEE9" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCV7</accession>
    <name>A0A103XCV7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005426">
        <property type="protein sequence ID" value="KVH88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCV7"/>
    <dbReference type="STRING" id="59895.A0A103XCV7"/>
    <dbReference type="Gramene" id="KVH88385">
        <property type="protein sequence ID" value="KVH88385"/>
        <property type="gene ID" value="Ccrd_023953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="270"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="399" mass="46404" checksum="CC12E89B5CE538DF" modified="2016-04-13" version="1">MINCIKKKKVSLRVSTDKRDSKKTEVSTFVNFIHQKDAFIAMKVVEAMLYLKAPVYTVHDTFLTLPYFSQKVADIYSNSVTRIGSPLLIKNRFLYHNVIPPNIEKYYQISKIYEDEWKYEVATIVRVMIRVFMENEKKTVMPSLSDDDRYNLLYSTLKAGLNNSEAITAREISHSKRKHTRHITAIKECQTNLHSFIVSDIETLPENNIHIPYSAGLLIVRPGKDLKDDMIETYYSEHYSLLVKNLEDKGSKVLYDLVLRISAIVQKDNSIRTVFFHNFSRFDGIIVLKHLARHHPQYKLKPLMINNRLYELSVYSGKKMLFCFRDSLNLLPGALRDLAKSLCPALGPKGSLNYNEFSESNLLINKEEYLDYMKQDILLLGGVMQKAQEIYWNLYNMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE70</accession>
    <name>A0A103XE70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/Kelch-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005317">
        <property type="protein sequence ID" value="KVH89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE70"/>
    <dbReference type="STRING" id="59895.A0A103XE70"/>
    <dbReference type="Gramene" id="KVH89043">
        <property type="protein sequence ID" value="KVH89043"/>
        <property type="gene ID" value="Ccrd_008970"/>
    </dbReference>
    <dbReference type="OMA" id="SCNQIDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010114">
        <property type="term" value="P:response to red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045890">
        <property type="entry name" value="POB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46336:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46336">
        <property type="entry name" value="OS02G0260700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BACK" evidence="5">
        <location>
            <begin position="262"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="515" mass="58665" checksum="3972F05626816DFC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFA7</accession>
    <name>A0A103XFA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005178">
        <property type="protein sequence ID" value="KVH89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFA7"/>
    <dbReference type="Gramene" id="KVH89675">
        <property type="protein sequence ID" value="KVH89675"/>
        <property type="gene ID" value="Ccrd_008331"/>
    </dbReference>
    <dbReference type="OMA" id="MERVYCD"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000033">
        <property type="entry name" value="Transcription factor jumonji (JmjC) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE JMJ25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="743"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131982" checksum="06C6AE46BB64C6B9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFL6</accession>
    <name>A0A103XFL6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_008141</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01005130">
        <property type="protein sequence ID" value="KVH89865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XFL6"/>
    <dbReference type="Gramene" id="KVH89865">
        <property type="protein sequence ID" value="KVH89865"/>
        <property type="gene ID" value="Ccrd_008141"/>
    </dbReference>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH89865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="48611" checksum="C247E8903908D09F" modified="2016-04-13" version="1">MTKTKENRDRGFLLQIATVNFKTEKQGHRTSAMAARKRGASKQPPPPAESYTKSPESTVTSTEPQITPAKPSKILLFSLIFFLPYFYLIFYHYRIETDLKQSILINASLSFAGFFVTLMMIPVASRYVIRRNLFGYDINKKGTPQGLIKVPESLGIVVGTVFLVVAILFQYFNFTSDSNWLVEYNAALASVCFMILLGFVDDVLDIPWRVKLLLPSIAALPLLMAYAGHTTIMIPKPLIEYVGTAILDLGWIYKLYMGLLAVFCTNSINIHAGINGLEVGQTVVIAFAILIHNIMQIGVSPNHETQQAHAFSIYLVQPLLATSLALLSYNWYPSSVFVGDTYTYFAGMTMAVVGILGHYSETLLIFFLPQIINFLLXLPQTGLLTGTNDGTLVNVSLRIFGRRSEKSLCILLLVLQGLGCCFCFFLRWILTGWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFS5</accession>
    <name>A0A103XFS5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cof protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005124">
        <property type="protein sequence ID" value="KVH89931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFS5"/>
    <dbReference type="STRING" id="59895.A0A103XFS5"/>
    <dbReference type="Gramene" id="KVH89931">
        <property type="protein sequence ID" value="KVH89931"/>
        <property type="gene ID" value="Ccrd_008077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00043">
        <property type="entry name" value="rRNA maturation RNase YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01144">
        <property type="entry name" value="C2.B.4:_PGP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="836" mass="91171" checksum="E9099536E62D6792" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFV4</accession>
    <name>A0A103XFV4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01005119">
        <property type="protein sequence ID" value="KVH90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFV4"/>
    <dbReference type="STRING" id="59895.A0A103XFV4"/>
    <dbReference type="Gramene" id="KVH90004">
        <property type="protein sequence ID" value="KVH90004"/>
        <property type="gene ID" value="Ccrd_007997"/>
    </dbReference>
    <dbReference type="OMA" id="RDYDTPD"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000040">
        <property type="entry name" value="UDP-glucose 4-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="347" mass="38098" checksum="D0FC154B153CE56F" modified="2016-04-13" version="1">MAPPLCVLVTGGAGYIGSHTVLQLLLDGYNTVVVDNLDNSSEVAISRVQELAGDRAHNLSFHKMDVRDKPALEQLFASTKFDAVIHFAGLKAVGESVEKPLMYYNNNIIGTLTLLEVMAAHGCKKLVFSSSATVYGWPKEVPCTEEFPLAAANPYGRTKLIIEEICRDIYASDPEWKVILLRYFNPVGAHPSGRIGEDPHGIPNNLMPFVQQVAVGRQPALQVYGTDYSTKDGTGVRDYIHVVDLAEGHAAALRKLSHPEIGCEVYNLGTGKGTSVLEMVSAFEKASGKKIPLVKGERRHGDAEIVYASTAKAERELNWKAKYGIEEMCRDQWKWASNNPYGYKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGF2</accession>
    <name>A0A103XGF2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGF2"/>
    <dbReference type="STRING" id="59895.A0A103XGF2"/>
    <dbReference type="Gramene" id="KVH90212">
        <property type="protein sequence ID" value="KVH90212"/>
        <property type="gene ID" value="Ccrd_007819"/>
    </dbReference>
    <dbReference type="OMA" id="KEIHEHH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF80">
        <property type="entry name" value="NUCLEOTIDE-BINDING ALPHA-BETA PLAIT DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="29472" checksum="29F914EA07F472F0" modified="2016-04-13" version="1">MKYCYLSDRIAILGPERNPCVGCALVLEFGQGTTLGGCGLLIEKVRPVDGGLRQWPGATIGDMTITVTLAPDYQLPPDAIPSLPPHGGNTSSEGESAFRKAEDVVSSMFAKGFVLGKDVVSKAKSFDEKHGLTSTASAKVTSFDKKIGFTEKVSTGTSIVNEKVKEVDQKLQVSEKAKSAFAAAEQTVSNAGSAIMKNRYVFTSAAWVTGAFNKVAKAASEVGQQTKEKVGQAEDEQKHKMVDDFAQVHLSESPKAASVPTEQQPPPSKPAPVQGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGR4</accession>
    <name>A0A103XGR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal-associated domain, HMA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGR4"/>
    <dbReference type="STRING" id="59895.A0A103XGR4"/>
    <dbReference type="Gramene" id="KVH90392">
        <property type="protein sequence ID" value="KVH90392"/>
        <property type="gene ID" value="Ccrd_007601"/>
    </dbReference>
    <dbReference type="OMA" id="KGMMDVK"/>
    <dbReference type="OrthoDB" id="773760at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044594">
        <property type="entry name" value="HIPP01/3/5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413:SF28">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED DOMAIN, HMA, HEAVY METAL-ASSOCIATED DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="43489" checksum="59C62A9E2F61AAB6" modified="2016-04-13" version="1">MGEKDSMKKEDNEKKVVDAGGTPKVEDSRITVVLKLHLHCDGCAKKIKRSLRYIEGVETVNIDSANNKLTIIGIVDPVHIKERVEFKTKKKVEIISPKPKKDDGGEKKVDDKPTEAKSNDQKPKEPQVITMVLKISLHCDGCIQKIKRIILKIDGVESVIADSSKNLVTVKGTMNMNELVPYLKEKLRRNVDIVPPKKEDNKVEEKKDEKKVEGGGDKKEKEGGNDGDDKKKTDVEKAPESNEGGEKKKNDVGKVTDGSEGGGEKKNDKVEATSGGDEKNKSDGEVKPPTGDGGSDGGNGGGGSKSVDLVNKSEYYRYNPYIYTMPVYNQNYHNQDYGLSVYPGRGYANEGYVNHGYVVEYPHGPPAPPPPMYLHDSRASGMDMLNAENPNACSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHD9</accession>
    <name>A0A103XHD9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable carboxypeptidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01005096">
        <property type="protein sequence ID" value="KVH90737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHD9"/>
    <dbReference type="STRING" id="59895.A0A103XHD9"/>
    <dbReference type="Gramene" id="KVH90737">
        <property type="protein sequence ID" value="KVH90737"/>
        <property type="gene ID" value="Ccrd_007239"/>
    </dbReference>
    <dbReference type="OMA" id="TEHGPCH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000060">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF494">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118803" description="Carboxypeptidase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="520" mass="57454" checksum="A636A0B7865A9DBA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHR9</accession>
    <name>A0A103XHR9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHR9"/>
    <dbReference type="STRING" id="59895.A0A103XHR9"/>
    <dbReference type="Gramene" id="KVH90949">
        <property type="protein sequence ID" value="KVH90949"/>
        <property type="gene ID" value="Ccrd_007043"/>
    </dbReference>
    <dbReference type="OMA" id="VWYHWAG"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25262" checksum="5C41C4F031DF1316" modified="2016-04-13" version="1">MDSSQIQPPSTSIISIQISIQNLIKCCKRRQNWEFFSGSTKQTSNSKPPWRTHLTAFLESTPVHVIAIVLLLVDLAMVVLELSKTLVSCPKSTRINKNVDVWYHWVGIGILAILATKSVALVVGCGSSFFRRPGLVADGVVLIGALLSEVLMERIGVGLIVVVSLWRVLRVVESAFELSDEAIQVQITTIFCQLELIREENEKLNRIIAEKNTIIEELQEQLNQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ64</accession>
    <name>A0A103XJ64_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004908">
        <property type="protein sequence ID" value="KVH91745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ64"/>
    <dbReference type="STRING" id="59895.A0A103XJ64"/>
    <dbReference type="Gramene" id="KVH91745">
        <property type="protein sequence ID" value="KVH91745"/>
        <property type="gene ID" value="Ccrd_006234"/>
    </dbReference>
    <dbReference type="OMA" id="GEMSACE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08870">
        <property type="entry name" value="START_STARD2_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000006">
        <property type="entry name" value="StAR-related lipid transfer protein 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF39">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="223"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="508" mass="57905" checksum="FDB60C3505284E8C" modified="2016-04-13" version="1" fragment="single">TRFSFLSTPFSLSFLLRDPPFTAVSNRSFLKPQSLLDWTEGFPSSSSSSFLFCGFWVFVISTKRLKNSSVSFYLLLMALVGALLKILQGPNLWNVLPDLMVFMLPLWIAVLFGVLVGWVWRPRWANSAINNLTTTYLPPKSYSSIDIVSSIPTFNSLKSQLPSYFFPFSDMGTLEVASSGPSSISFPDSSLSKLDNERKNFVGEDDLKHISKLVEEKDGGLSWIGMMDRSTSNMSYQAWRRDPEIGPPQYRSRTVYEDTTPELMRDFFWDDEFRLKWDDMLLEAETLEECPNNGTMVVKWVRKFPFFCSDREYIIGRRIWESGKTYYCVTKGIQYPSVPRRTKPRRVDLYYSSWSIRAVESRKGDGEMSACEVLLFHHEDMGIPWEIAKLGVRQGMWGAVKKIDRGLRWYQKHMASGAPLSHCAYMAHINSKVSSERLRYLQNTTNDSQEIETCEAASDDEKPSGKNIPKLLVVGGAIALACTIDRGLLTKAVIFGVARRFAKMGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ74</accession>
    <name>A0A103XJ74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004905">
        <property type="protein sequence ID" value="KVH91770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ74"/>
    <dbReference type="STRING" id="59895.A0A103XJ74"/>
    <dbReference type="Gramene" id="KVH91770">
        <property type="protein sequence ID" value="KVH91770"/>
        <property type="gene ID" value="Ccrd_006187"/>
    </dbReference>
    <dbReference type="OMA" id="YENDYSI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13301">
        <property type="entry name" value="X-BOX TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="41833" checksum="D271D4A6F9A57D43" modified="2016-04-13" version="1" fragment="single">FLENLEKVLKKKDFPVLDIFICTADPYKELAINVVNTSLFLMAYDYPPEKRSRCMFPTVVALSLLSLLSWRLPSLQQFGCCFVGIITSWIDAQRPYFNQMKLHFLTVPRSKVQVSVVMTNALIVLTQDRNMYSNDTKTPEWVLCFYADYSIRYIYDNYENDYSIHYILAHEVAGSNYENDLVWGSKIGFSYGSLSENSFTGLHQHSKGWKSLFFHPRRPVFLGDLLISLYDALNQNRRWCIGFLEVVFQNTTLLTFGSRFMGPLVGLAYAHNALLPIWSISIIIGHCTTSSSQTSRVCGFLCTLFSFLRPTCKIVLISCWLMGCSNNGGQSIDVAHTRSLIIPFRIHRILDQTPWDCIERVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL08</accession>
    <name>A0A103XL08_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CMP/dCMP deaminase, zinc-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004810">
        <property type="protein sequence ID" value="KVH92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL08"/>
    <dbReference type="STRING" id="59895.A0A103XL08"/>
    <dbReference type="Gramene" id="KVH92672">
        <property type="protein sequence ID" value="KVH92672"/>
        <property type="gene ID" value="Ccrd_005290"/>
    </dbReference>
    <dbReference type="OMA" id="QHWPTSF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="41342" checksum="83C576FB880C2BC8" modified="2016-04-13" version="1">MHKCKEKECWEIIHIPDKSPFPPHQQPTVKVYAAVIDPKLTNTLVRKLNQILPLENLRHVKRVCRYAPVSKEEWEEQCKIWPTSYHPPTYNISGITGFSEEESHSVCTFMKLALELAKCKGQMVNAAVIVDPSTNQVIARACDQVHSCSCSINHEVTTSTSFAYRTQNHDNMLLNSSATEPKLLYHGGSCLNPWQWSNQSSCGSSCSWHPLRHAAVVAIEHSAARDRRLFPCSGLAADDLDETDHLRADLTCPSSKKQKTKSMQVKDDDELNSHSNGCHPELARPYLCTGYDIYLVWEPCAMCAMALVHQRVKRIFYGFPNPTAGALGSVHRLQGEKSLNHHYAVFKVMLPEEIHLDEGKSLVLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM34</accession>
    <name>A0A103XM34_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004792">
        <property type="protein sequence ID" value="KVH93165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM34"/>
    <dbReference type="Gramene" id="KVH93165">
        <property type="protein sequence ID" value="KVH93165"/>
        <property type="gene ID" value="Ccrd_004762"/>
    </dbReference>
    <dbReference type="OMA" id="YMHTYQQ"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF163">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="660" mass="74644" checksum="1D7BA2F276BA7E98" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMA1</accession>
    <name>A0A103XMA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004774">
        <property type="protein sequence ID" value="KVH93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMA1"/>
    <dbReference type="STRING" id="59895.A0A103XMA1"/>
    <dbReference type="Gramene" id="KVH93391">
        <property type="protein sequence ID" value="KVH93391"/>
        <property type="gene ID" value="Ccrd_004567"/>
    </dbReference>
    <dbReference type="OMA" id="ITEHYTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF46">
        <property type="entry name" value="CAROTENOID CLEAVAGE DIOXYGENASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="576" mass="64365" checksum="4F9285E43E3924DF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN43</accession>
    <name>A0A103XN43_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Purple acid phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_004199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="13"/>
    <dbReference type="EMBL" id="LEKV01004606">
        <property type="protein sequence ID" value="KVH93755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN43"/>
    <dbReference type="STRING" id="59895.A0A103XN43"/>
    <dbReference type="Gramene" id="KVH93755">
        <property type="protein sequence ID" value="KVH93755"/>
        <property type="gene ID" value="Ccrd_004199"/>
    </dbReference>
    <dbReference type="OMA" id="SSMWITW"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051174">
        <property type="term" value="P:regulation of phosphorus metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.380:FF:000001">
        <property type="entry name" value="Fe(3+)-Zn(2+) purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000034">
        <property type="entry name" value="Fe(3+)-Zn(2+) purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF55">
        <property type="entry name" value="BIFUNCTIONAL PURPLE ACID PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="16">
        <location>
            <begin position="64"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="166"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="15">
        <location>
            <begin position="389"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH93755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="487" mass="56447" checksum="9A7FD577DD46980E" modified="2016-04-13" version="1">MIHLKEKKMGSMISQFLLIGYVLFIFLDNVYAGVTSNFIRSEWPSVDIPLDNEVFAIPSGYNAPEQVHITQGDYDGKGVIIIWVTPEKPGSNQVRYGTSEKKYDFTAEGTVKNYTFYNYTSGYIHQCLVNDLEYDTKYFYEIGEGDSARSFWFQTPPKIDPNASYKFGIIGDLGQTYNSLSTLEHYIQSGAQTVLHVGDLSYADRYQYHDMGVRWDSYGRFVEKSAAYQPWLWTVGNHEIEYMPYMEEVVPFKQYLYRYTTPYAASGSSNPLWYAVRRASAHIIVLSSYSPFVKYTPQWEWLQAEFKKVDRKKTPWLIVVMHAPIYNSNSAHYMEGESMRVAFESWFVQYKVDVVFAGHVHAYERSYRISNIQYNVTGGAMYPVPDKSAPVYITVGDGGNQEGLASRFNDPQPDYSAFREASYGHSTLEIMNKTHAFYHWNRNDDGKKVPTDSFVLHNQYWNKSLRRRKLKKKYLHAIVPTLELNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN72</accession>
    <name>A0A103XN72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maintenance of Photosystem II under High light 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004596">
        <property type="protein sequence ID" value="KVH93818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN72"/>
    <dbReference type="STRING" id="59895.A0A103XN72"/>
    <dbReference type="Gramene" id="KVH93818">
        <property type="protein sequence ID" value="KVH93818"/>
        <property type="gene ID" value="Ccrd_004118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010206">
        <property type="term" value="P:photosystem II repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038862">
        <property type="entry name" value="MPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049072">
        <property type="entry name" value="MPH2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35742">
        <property type="entry name" value="THYLAKOID LUMENAL 16.5 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35742:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 16.5 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20675">
        <property type="entry name" value="MPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maintenance of Photosystem II under High light 2 C-terminal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="434" mass="45479" checksum="8FB70B9B2A92CE71" modified="2016-04-13" version="1">MAAIFLANPSTFLPSSSTSMQKHIVKGTSVCKPVNKLPNYPPQVSKRSLSISLTSLFLLSSTGNPHGANAAILEADDDLELMEKVKKDRKKRIEKQTVLNSSSKDKDYLQDVIYKLSKIGQAIENNDLPSAGSVLGQTLDADWVKMANVALSKTPNAMTELQITEMFVSNKIHQKQTMLTERIGSTNTCYSIFISSQEGWASLTSTTGQPFSAAVAPPASTLVTGTESSIAVSSTTLVTSSGGGVSGFSSTSSLTSFAGLATSSIGGSSWFSHASSLTASPSSCLLLTPPLLLGLATSSVGGTSGISLFPSASSLGFSSSFSAFSASCISTSFSSGASSFSFLSFFEDDDFLGRFFTGSFSAGGGVDFTFSLILEDLRGVSPLPQSNSEILGPPGCDFRYCSSCFLFVISSPVGAVNTVSFFLGVPPFFSKHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP83</accession>
    <name>A0A103XP83_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004553">
        <property type="protein sequence ID" value="KVH94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP83"/>
    <dbReference type="STRING" id="59895.A0A103XP83"/>
    <dbReference type="Gramene" id="KVH94412">
        <property type="protein sequence ID" value="KVH94412"/>
        <property type="gene ID" value="Ccrd_003526"/>
    </dbReference>
    <dbReference type="OMA" id="YCCGCES"/>
    <dbReference type="OrthoDB" id="761790at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040267">
        <property type="entry name" value="EID1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31348">
        <property type="entry name" value="EID1-LIKE F-BOX PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31348:SF3">
        <property type="entry name" value="EID1-LIKE F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="302" mass="33605" checksum="691AFF2CF633534F" modified="2016-04-13" version="1">MSANQRVRLNTASSGSGSGSNEPDIFNERVLLLVMEWMKWDVQLLCRTASVCRRLRAMAKRLLWRELCLFRAPRITETLSNGVHSSRMGGGWPALAKLLFFCGGCESSRNFVLSRPKPGHFVMESRFSKTSGRSFLMKRCRGDLLFVSDPCEHRMGDREDDLGVFRGVFRGFRESKTRACLIARQVALEEKDRCPYCGARVWSMTTAGLVPRNAAKRLGSHEGALEYFVCVNGHLHGTCWLAPLSSDEGVNGDDEIEEYEMDGSYGSGGTGNNSGGVTDGFFDDPTAGNRFQYDVYNGCTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPA1</accession>
    <name>A0A103XPA1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPA1"/>
    <dbReference type="STRING" id="59895.A0A103XPA1"/>
    <dbReference type="Gramene" id="KVH94340">
        <property type="protein sequence ID" value="KVH94340"/>
        <property type="gene ID" value="Ccrd_003598"/>
    </dbReference>
    <dbReference type="OMA" id="YDETIMD"/>
    <dbReference type="OrthoDB" id="642974at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF103">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="245" mass="26272" checksum="5E1C430931C995A0" modified="2016-04-13" version="1">MTTSFDETELRLGLPGGGGGAGGGNKTSEGGDAVVHVNGKRGYDETIMDLKLKLSSDDQENKNDTEKNLFAGGDGVDGGCSGDPPAKTQVVGWPPVRAYRKNMMSVQKKSCLRRHEDANGGGGGGGGAAFVKVSMDGAPYLRKVDLKMYKSYQDLSDALGNMFSSFIIGNCGSQGLKDFMNESKVMDLLNNSYEDKDGDWMLVGDVPWEMFVDSCKRLRITKGKEAIGLAPIAMDKCKTEAKSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPW5</accession>
    <name>A0A103XPW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004528">
        <property type="protein sequence ID" value="KVH94744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPW5"/>
    <dbReference type="STRING" id="59895.A0A103XPW5"/>
    <dbReference type="Gramene" id="KVH94744">
        <property type="protein sequence ID" value="KVH94744"/>
        <property type="gene ID" value="Ccrd_003194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="104" mass="11729" checksum="F00FC96E0A011DC3" modified="2016-04-13" version="1">MQVSERTQRLNAARRSNLYRGSARMAYAAVKSAKIGLEEPQEQIHKIRITLSSKNVKNLEKGISVCNLNFSFPLLSNKNTNGYNSRSCLKTSHLKGIYCYVICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ13</accession>
    <name>A0A103XQ13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004520">
        <property type="protein sequence ID" value="KVH94804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ13"/>
    <dbReference type="STRING" id="59895.A0A103XQ13"/>
    <dbReference type="Gramene" id="KVH94804">
        <property type="protein sequence ID" value="KVH94804"/>
        <property type="gene ID" value="Ccrd_003128"/>
    </dbReference>
    <dbReference type="OMA" id="AHYQQYY"/>
    <dbReference type="OrthoDB" id="781635at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051886">
        <property type="entry name" value="Seed_Dev/Stress_Resp_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46354">
        <property type="entry name" value="DOG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46354:SF13">
        <property type="entry name" value="PROTEIN DOG1-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOG1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="237" mass="27771" checksum="F3128084E5F8C0FE" modified="2016-04-13" version="1">MAAKSRRTANINVREFENFFQGWLVRQEHYLEELRSALRICDESRDEDLCDLIARVLEHYQQYYEEKSRIANYDVSLVFSPPWFSPFEQSFFWIAGFKPGLAFRILAASVDDMSKEQSERMETLKVEMKTEERELENELARIQESVAAPPIVEVARKDNLPVDGEYDTADMESVMETLKSEMEVVLANADMLRSRTAERLVEILTPVQNVRFLTAVTELQLKIRMWGSQMDADRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUY1</accession>
    <name>A0A103XUY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S10, serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003837">
        <property type="protein sequence ID" value="KVH97339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUY1"/>
    <dbReference type="Gramene" id="KVH97339">
        <property type="protein sequence ID" value="KVH97339"/>
        <property type="gene ID" value="Ccrd_000557"/>
    </dbReference>
    <dbReference type="OMA" id="VWANDMK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000072">
        <property type="entry name" value="Serine carboxypeptidase-like 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF438">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119130" evidence="2">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="49484" checksum="F46A6DA79A6CCB7F" modified="2016-04-13" version="1">MEYFGSKSLTCLLLLLLTLESELFIAPVLSKSIVSTLPGYPGELPFKLETGYVGIGEKEDAQFFYYFVESEGNPEEDPLIFYLTGGPGCSAVITFFYQIGPLTFNFDHAPENLTIERNPNSWTKMANVIFVDMPAGTGFSYATSKEGWISSDSIIVKQATDFLRKFLIDHPKFLNNPLYISAISYMGIVTPSITLELYNANERGDQPALNIQGYILCSPLTDKFMDFNSRIEYAHRMALISDDIYKSATENCRGNYVNADGANSICKNSLDRYQEEYYYDFAVDWANEEAVQQALNIRPGTIGKWEFYNTTMHYREDKNDTFCYAYDMFSSFAYHKKLVSKNCRALIFSGDHDMTFPYVGIEDWISALNLGIDRPWKPFYVDGQVGGYDMTYAQNDYSLTFATVKGAGHSVAQYKPREAYVLTERWLASKSYSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW66</accession>
    <name>A0A103XW66_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphotransferase</fullName>
            <ecNumber evidence="9">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_023809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW66"/>
    <dbReference type="STRING" id="59895.A0A103XW66"/>
    <dbReference type="Gramene" id="KVH97993">
        <property type="protein sequence ID" value="KVH97993"/>
        <property type="gene ID" value="Ccrd_023809"/>
    </dbReference>
    <dbReference type="OMA" id="FMAINCE"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF85">
        <property type="entry name" value="HEXOKINASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="11">
        <location>
            <begin position="257"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="395" mass="42491" checksum="F75F823FB854582E" modified="2016-04-13" version="1">MGKVTVGVAVVGAAAVCAAAALIARHRMRSSSLCVKAADILKELEEKCATPAAKLKQIADAMTVEMHAGLASEGGSKLKMLISYVDNLPTGKEEGVYYALDLGGTNFRVLRVQLGGKSGIEFTEFAEVTIPPQLMIGTPEVRFSFLSQLMQNLLSVQFALFDYIASELAKFVSDESEKFWLPPGRQRELGFTFSFPVNDTVGTLAGGRYENSDVCIAVILGTGSNAAYVERAQAIPKWHGPHPKSGEMVINMEWGNFRTPEMSAMHHDTSADLKVVGNTLKDILGISDTSLSTRKIVVEVCNIIATRGARLAAAGILGILKKMGRDTVRDGEVPKTVIAMDGGLYEHYTGYRNCLENTLHELVGDQLSQHIKLILSNDGSGIGAALLAASHSRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWT5</accession>
    <name>A0A103XWT5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003801">
        <property type="protein sequence ID" value="KVH98331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWT5"/>
    <dbReference type="STRING" id="59895.A0A103XWT5"/>
    <dbReference type="Gramene" id="KVH98331">
        <property type="protein sequence ID" value="KVH98331"/>
        <property type="gene ID" value="Ccrd_023440"/>
    </dbReference>
    <dbReference type="OMA" id="YKEASCC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044837">
        <property type="entry name" value="REM16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391:SF116">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS06G0194400-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="19396" checksum="B8C84CBB6A46B611" modified="2016-04-13" version="1">MKRTKPRVIGTEMVEVRRSSRVANKPAPVYKEIVVYERVDLPRSSRRYTYSRRDLANRVYASDEAREYAINKADELEAMLEGGHPSFVKPMLQSHVTGGFWLGLPGHFCRKNLPKKDGTVTLIDEEGEEFPTVYLAHKAGLSGGWRGFSISHGLVDGDALVFQQTKPTVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXR3</accession>
    <name>A0A103XXR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXR3"/>
    <dbReference type="STRING" id="59895.A0A103XXR3"/>
    <dbReference type="Gramene" id="KVH98883">
        <property type="protein sequence ID" value="KVH98883"/>
        <property type="gene ID" value="Ccrd_022889"/>
    </dbReference>
    <dbReference type="OMA" id="GVICELW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF21">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 27-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="241" mass="27735" checksum="E580FD800526573B" modified="2016-04-13" version="1">MTLKGATTSQACAACKYQRKRCTPECALAPHFRPEHPTVFRNVHKLFGVRKILRILEEIDHYQQPEAMRSIIYEANMRDQFPVHGCLGVICELWCQIRQAEDELRSVLTRLAFYKQDHEQQRTTALSPVVFRGSLQLGMAIAPPDIAPLTLFQDEATTTMPISSHNNTGMCINTLWLQETNNTNNHHHSPLMSQPSVIEEAVNNHDGIFPFFDHIEDRQLHIDSKEKNESRYATFIRRIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY30</accession>
    <name>A0A103XY30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY30"/>
    <dbReference type="Gramene" id="KVH98926">
        <property type="protein sequence ID" value="KVH98926"/>
        <property type="gene ID" value="Ccrd_022832"/>
    </dbReference>
    <dbReference type="OMA" id="GIHGFCL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900864">
        <property type="term" value="P:mitochondrial RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000351">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF347">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="551" mass="61606" checksum="AF03357F20177A19" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZL4</accession>
    <name>A0A103XZL4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZL4"/>
    <dbReference type="STRING" id="59895.A0A103XZL4"/>
    <dbReference type="Gramene" id="KVH99794">
        <property type="protein sequence ID" value="KVH99794"/>
        <property type="gene ID" value="Ccrd_021972"/>
    </dbReference>
    <dbReference type="OMA" id="TPTKCNG"/>
    <dbReference type="OrthoDB" id="587249at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22269">
        <property type="entry name" value="DPBB_EG45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47480">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47480:SF6">
        <property type="entry name" value="EXPANSIN-LIKE EG45 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119232" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="14678" checksum="54C36E1A281D7AF2" modified="2016-04-13" version="1">MGMGMGMGMVVTVCLFLMLGFNNIKYGLADIGTASSYQPPYTPTKCNGNRADQFPSGNLFASVSEGLWDNGAACGRRYRLKCLSGNNKPCIGGTIDVKVIDFCSKRPCPSTIVLSSDAFSAISKSQKGKINIEYVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZS4</accession>
    <name>A0A103XZS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003409">
        <property type="protein sequence ID" value="KVH99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZS4"/>
    <dbReference type="STRING" id="59895.A0A103XZS4"/>
    <dbReference type="Gramene" id="KVH99871">
        <property type="protein sequence ID" value="KVH99871"/>
        <property type="gene ID" value="Ccrd_021879"/>
    </dbReference>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF105">
        <property type="entry name" value="MPV17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="212" mass="24431" checksum="0EB969972E7F7A3A" modified="2016-04-13" version="1">MVLLKLWRWYQNCLSVHPVKTQIISSGLIWGIGDIAAQAVTHSTALKNKSVSISKEDQELRIKWKRVATTSLFGMAFVGPVGHFWLRLQYQPKSMRFVATKVALDGIIFGPVDLLVFFSYMGFASGKNVNQVKEDVKRDFIPALLVEGGIWPIVQVANFRFVPVRYQLLYVNLFCLLDSCFLSWLEQQQDAVWKKQWFKCLFEVKQHKNQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0A7</accession>
    <name>A0A103Y0A7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arogenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from L-arogenate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003399">
        <property type="protein sequence ID" value="KVI00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0A7"/>
    <dbReference type="STRING" id="59895.A0A103Y0A7"/>
    <dbReference type="Gramene" id="KVI00096">
        <property type="protein sequence ID" value="KVI00096"/>
        <property type="gene ID" value="Ccrd_021659"/>
    </dbReference>
    <dbReference type="OMA" id="IAFRNIN"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047769">
        <property type="term" value="F:arogenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000031">
        <property type="entry name" value="Arogenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF28">
        <property type="entry name" value="AROGENATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="224" mass="25172" checksum="9B0E989BFB1C1FC7" modified="2016-04-13" version="1" fragment="single">MSKKSLSTSGPPLPTSTRLLALPGVRKEYLNRVISLTQALSQCELTLTELGLNVRPEFFYSTVGAAYFIAENNLHDTAAIASERAEKIYGLNVLADGMHNDSNNVTYFLMLAREPIITHTDRPFRTGIVFAHNKGTFVLFKVLSVIAFRNINLTKIKSRPRRLRPITIVGDTNVGTAKHFFEYIFYVEFEASTAEVRAQNALADVQEFTSFLRVLGSYRMDMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y165</accession>
    <name>A0A103Y165_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003364">
        <property type="protein sequence ID" value="KVI00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y165"/>
    <dbReference type="STRING" id="59895.A0A103Y165"/>
    <dbReference type="Gramene" id="KVI00637">
        <property type="protein sequence ID" value="KVI00637"/>
        <property type="gene ID" value="Ccrd_021106"/>
    </dbReference>
    <dbReference type="OMA" id="GPYEVNG"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="26040" checksum="E680E4A1F48060DC" modified="2016-04-13" version="1">MAPKDRKPHVCRNPDLIRGVGKYSRSKMYHKRGLWAIKAKNGGAFPKHEKKAAAAALPEKPPKFYPADDVKKPLVNKRKARPTKLRASITPGTVLIILAGRFKGKRVVFLKQLTSGLLLVTGPFKINGVPLRRVNQSYVIATSTKADITAVNVEKFDDKYFGKKVEKKKKKGEGEFFEAEKEEKNTLPQEKKDDQKTLDAALITSIEAVPDLKSYLGARFSLKAGMKPHELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y208</accession>
    <name>A0A103Y208_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May play a role in protein folding in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003133">
        <property type="protein sequence ID" value="KVI01074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y208"/>
    <dbReference type="STRING" id="59895.A0A103Y208"/>
    <dbReference type="Gramene" id="KVI01074">
        <property type="protein sequence ID" value="KVI01074"/>
        <property type="gene ID" value="Ccrd_020661"/>
    </dbReference>
    <dbReference type="OMA" id="WFWRYTV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000050">
        <property type="entry name" value="Chaperone protein dnaJ 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119311" evidence="11">
        <location>
            <begin position="26"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="339" mass="39984" checksum="5B35AECA8933EAEC" modified="2016-04-13" version="1" fragment="single">MVTTPFRCYAVVLLTVIFFIQPSISIYCDEDDCYDLLGVSQNSNSSEIKKAYYKLSLKHHPDKNPDPESKKLFVKIANAYEILKDEVTRGQYDYAIEHPEEVFYNAARYYHAYYGHKTDPRAVLVGLLLVLSAFQYLNQWTRYHQAIDMVKRTPAYKNKLKALELERTGAMSSKKKGGYKIDKKTQEDLSKELELQIKGAEKPSMWGLLGVRFILLPYTLGKLVLWYGSWYWRYKINQTSYSWEDASYLTRRALGAPPDSWEYLGKAIHLFGKIYFIYLISFMYKFAVELKYGLYESSKKDLINRRLWVKSNLESYLSEMRKESKRRRWNSLEYTLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2Y5</accession>
    <name>A0A103Y2Y5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003023">
        <property type="protein sequence ID" value="KVI01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2Y5"/>
    <dbReference type="STRING" id="59895.A0A103Y2Y5"/>
    <dbReference type="Gramene" id="KVI01565">
        <property type="protein sequence ID" value="KVI01565"/>
        <property type="gene ID" value="Ccrd_020161"/>
    </dbReference>
    <dbReference type="OMA" id="KMIWWID"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24937" checksum="5269F7D061B96686" modified="2016-04-13" version="1">MDLNPPSGENYANPRICFFHVLFKAGALAFYILSALFFDSFVIIFVVTVLLSALDFWVVKNVSGRILVGLRWWNEIDDNGESVWKFECLDQESLARMNKKDSWLFWWTLYLTVSEYLLPVNQAKINLSANATLMDLLALALMLEIPFMAVIWIFFGIFSLIRFQADYLLVVGVCLTLSVANIVGFTKCRKDAKKQIQAFASQTIANRFQSTIQSAFSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3K3</accession>
    <name>A0A103Y3K3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002675">
        <property type="protein sequence ID" value="KVI01872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3K3"/>
    <dbReference type="STRING" id="59895.A0A103Y3K3"/>
    <dbReference type="Gramene" id="KVI01872">
        <property type="protein sequence ID" value="KVI01872"/>
        <property type="gene ID" value="Ccrd_019847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI01872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="781" mass="87565" checksum="345959181E891DC5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6N8</accession>
    <name>A0A103Y6N8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002347">
        <property type="protein sequence ID" value="KVI03504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6N8"/>
    <dbReference type="STRING" id="59895.A0A103Y6N8"/>
    <dbReference type="Gramene" id="KVI03504">
        <property type="protein sequence ID" value="KVI03504"/>
        <property type="gene ID" value="Ccrd_018186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33450">
        <property type="entry name" value="EMB|CAB67623.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33450:SF4">
        <property type="entry name" value="OS04G0665666 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="173" mass="20445" checksum="E920ED973EB89412" modified="2016-04-13" version="1">MPFSIQMASPPSTSKKLKTLIRNFIVSQLSCIDVVLAKAKLVCTEFVEETNLKNVHMLLSLMFKKNKNKNRFNLSSFRFYYNWSSSHVVPKSSIYDGYVSYDPTWDSFEEEATSELHDLSRYLHWLEEKNNRAYDINDIDSLADKYIANCHQKFILEKQESDRRFQEMMMRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8P1</accession>
    <name>A0A103Y8P1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001980">
        <property type="protein sequence ID" value="KVI04571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8P1"/>
    <dbReference type="STRING" id="59895.A0A103Y8P1"/>
    <dbReference type="Gramene" id="KVI04571">
        <property type="protein sequence ID" value="KVI04571"/>
        <property type="gene ID" value="Ccrd_017111"/>
    </dbReference>
    <dbReference type="OMA" id="ITSACDR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009850">
        <property type="term" value="P:auxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08017">
        <property type="entry name" value="M20_IAA_Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044757">
        <property type="entry name" value="ILR1-like_Hyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF140">
        <property type="entry name" value="IAA-AMINO ACID HYDROLASE ILR1-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119493" evidence="6">
        <location>
            <begin position="33"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="194"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="44187" checksum="CD9CF51AD6A7E5A2" modified="2016-04-13" version="1">MLKLLISPSSFGILLLLFIPVFLLSSIQIVYGDEDYEAQLLTSAKHDTDWLISIRRKIHENPELRFQEHNTSALIRNQLQKLGISYTYPLARTGFVAQIGTGSPPIVALRADMDALPLQELVEWEHKSKRDGGTVRLIFQPAEEGGAGASVMIEEGALGGAEAIFGMHVHSSLPTGSIATLSGPMMAATCFFAARIEGKGGHAAEPHNSVDPVLAASSTVLALQQLISRELDPLQSQVLSVTYVRAGEALNVIPSYVELRGTLRSLTTEGLQHLQRRVKEVVEGQAAVHRCKGSVDMMEKEFPPYPATINDETLNRHVNKVGSLLLGAERVKGSNQVMAGEDFAFYQQKIPGVMFGIGIHNEDIGSIHPPHSPYFFLDEDALPIGAALHTALAELYLNQHQTSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8Q4</accession>
    <name>A0A103Y8Q4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">NAD(P)H dehydrogenase subunit 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">NADH-plastoquinone oxidoreductase subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_017093</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001975">
        <property type="protein sequence ID" value="KVI04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8Q4"/>
    <dbReference type="STRING" id="59895.A0A103Y8Q4"/>
    <dbReference type="Gramene" id="KVI04589">
        <property type="protein sequence ID" value="KVI04589"/>
        <property type="gene ID" value="Ccrd_017093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002128">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chlpt_su5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01010">
        <property type="entry name" value="Proton_antipo_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="8" id="KW-0874">Quinone</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal" evidence="21">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal" evidence="21">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVI04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13915" checksum="13D523827DB315BC" modified="2016-04-13" version="1" fragment="single">HLNVHFQNYSRKKNIAFYSISLWGKEGSKIVYKTDENTYSYPYESDNTMLFPILILIIFTLFVGFLGIPFSQYMVNLDILSKWLTTSINLLYKNSNNSIDWYEFCKYAVFSVSIASFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8Z4</accession>
    <name>A0A103Y8Z4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001933">
        <property type="protein sequence ID" value="KVI04717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8Z4"/>
    <dbReference type="STRING" id="59895.A0A103Y8Z4"/>
    <dbReference type="Gramene" id="KVI04717">
        <property type="protein sequence ID" value="KVI04717"/>
        <property type="gene ID" value="Ccrd_016961"/>
    </dbReference>
    <dbReference type="OMA" id="DGHEAQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055280">
        <property type="entry name" value="TIC32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48476">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE TIC 32, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48476:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE TIC 32, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="25881" checksum="E06C1E6154074E27" modified="2016-04-13" version="1">MWLFRKPGPSGFSHYSTAEQVTDGIDASGLTAIVTGGSSGIGRETARVLALRGAHVVMGVRNMTAGKQVQEAIMNEIATAKIDAMELDLNSMASVRKFASDFNSSGQSLNLLIYSKYQAYGQSKLANILHANELTRRLKEEGAEITANSLHPGVISTNLFRHIFTPPSFAEGFVSKLSSCLMKNVEQGAATTCYLALHPAVKGVSGKYFLDSNLAETTEQGKDMDLAKRLWDFSINLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y936</accession>
    <name>A0A103Y936_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001923">
        <property type="protein sequence ID" value="KVI04750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y936"/>
    <dbReference type="STRING" id="59895.A0A103Y936"/>
    <dbReference type="Gramene" id="KVI04750">
        <property type="protein sequence ID" value="KVI04750"/>
        <property type="gene ID" value="Ccrd_016929"/>
    </dbReference>
    <dbReference type="OMA" id="NSWFKSG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12937">
        <property type="entry name" value="GUCT_RH7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="58"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="259"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="586" mass="63351" checksum="CAFE19807F647606" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAD2</accession>
    <name>A0A103YAD2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 214</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAD2"/>
    <dbReference type="STRING" id="59895.A0A103YAD2"/>
    <dbReference type="Gramene" id="KVI05454">
        <property type="protein sequence ID" value="KVI05454"/>
        <property type="gene ID" value="Ccrd_016232"/>
    </dbReference>
    <dbReference type="OMA" id="DWINHRP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF14">
        <property type="entry name" value="F26K24.17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68734" checksum="80BAFAE78033AEDE" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBQ1</accession>
    <name>A0A103YBQ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001847">
        <property type="protein sequence ID" value="KVI06159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBQ1"/>
    <dbReference type="Gramene" id="KVI06159">
        <property type="protein sequence ID" value="KVI06159"/>
        <property type="gene ID" value="Ccrd_015512"/>
    </dbReference>
    <dbReference type="OMA" id="QKIIAMG"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000003">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF22">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="295" mass="32881" checksum="B417503C425A4A18" modified="2016-04-13" version="1">MIAHLAQLTLAFGLLGNIVSFMVFLAPIPTFYKVYKKKSTEGFQSAPYVVGLFSAMLWIYYALLKSNVLLLITINSVGCFIETLYICFFLFYAPKKARMESLKLIVLLIVVGFGLIVGLTQLFATGVTRGVIVGWICLVFSLCVFVAPLGVLRQVIKTKSVEYMPILLSVALTLSAVMWFFYGLLLGDFNIAIPNVLGFTFGIIQMILYFIYKNKKPVIIDEKISKFEEKITAMEVQRIPEFKDTKSIDVVELKGMMPAEILSGVGKYADNANHAVVNPQALRNMPNHMTIEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCD6</accession>
    <name>A0A103YCD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_015159</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001821">
        <property type="protein sequence ID" value="KVI06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCD6"/>
    <dbReference type="STRING" id="59895.A0A103YCD6"/>
    <dbReference type="Gramene" id="KVI06492">
        <property type="protein sequence ID" value="KVI06492"/>
        <property type="gene ID" value="Ccrd_015159"/>
    </dbReference>
    <dbReference type="OMA" id="FTMRPHP"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF22">
        <property type="entry name" value="CYTOCHROME P450 83B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119598" evidence="16">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="500" mass="57162" checksum="15954121C8FB27E3" modified="2016-04-13" version="1" fragment="single">MALHFLFLLLSLLLVYLISKTFISKSRFNPPGPPTLPFIGNLHQIHLSNLHTSLWHLSKSYGPIIYLRFGFIPAIVVSSASLAKEVLKTQDIIFCSKAPLCGQLKLSYDGLDVAFSPYNKNWKDMRKIFMLHLSGPKSVQSFRHIREDDVSTTMKNIHRLALSSKHVNLSEIMKSMTSNMMLRVGFGMRYQDGHERKEVLQLLTEFQAVVAEFFVSDIWPGLPFVGLVDRLLGKVDRVQKCFKYFDSFYQQLIDEHLNLQNPNKSHDQEEEDFIDILLRIKKDQLSNLTYDHIKAMLMNVLVAGTDTIAVTVVWAMTALIKNPKVMKKAQEEVRNVVGKKGKVDEDDLPKLTYLKAVVKETLRLYPPAPLLIPRETTKDAILHGYKIKQKTLVFVNALAIGRDPECWESPELFLPERFVGRDIDFRGNDFEFIPFGAGRRICPGISMADVMVDLLLANLIYLFDWDLPDGMSKEDVDFEVLPGLIMHKRNELCLLAHVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEI9</accession>
    <name>A0A103YEI9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mad3/BUB1 homology region 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001499">
        <property type="protein sequence ID" value="KVI07645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEI9"/>
    <dbReference type="STRING" id="59895.A0A103YEI9"/>
    <dbReference type="Gramene" id="KVI07645">
        <property type="protein sequence ID" value="KVI07645"/>
        <property type="gene ID" value="Ccrd_013990"/>
    </dbReference>
    <dbReference type="OMA" id="LRIWMQY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF19">
        <property type="entry name" value="MITOTIC SPINDLE CHECKPOINT PROTEIN BUBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="2">
        <location>
            <begin position="73"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="373" mass="42685" checksum="D832D60A664B39EC" modified="2016-04-13" version="1">MEENVPTITMPLFMDPETEFLASKQVTGNEWELFKENVRPLKRGRNVKLLNDSLKSHADIQIRNSLIDTRRKLIKAIDEYEGEDPLQPWLDCIKWIQDAFPPGGDCSGLVVIFEQCVRTFWHEEHYKNDLRYLKVFLDTNKIGETHSIFYITYASHLESKNKIRTANDIFELGISRNAQPIEKLKSAYKSFFARTMNRPRASEEELMDTRQPVRSFGTILARKDSGNRTLESSDIARKRPKQDGPGASLKVFKETSTMARSSMHQSEPPKSDLKPWHTLGARAERNKENNAIPAMWTSNKIPQRPVHRIGGATAPPCIEVFVDEECSEPHNVSSEGGRSSALQLRNKDGSDLKKETELLRENPLRHFPPSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGD8</accession>
    <name>A0A103YGD8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnogalacturonate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001100">
        <property type="protein sequence ID" value="KVI08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGD8"/>
    <dbReference type="STRING" id="59895.A0A103YGD8"/>
    <dbReference type="Gramene" id="KVI08630">
        <property type="protein sequence ID" value="KVI08630"/>
        <property type="gene ID" value="Ccrd_012996"/>
    </dbReference>
    <dbReference type="OMA" id="MIVAIHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010325">
        <property type="entry name" value="Rhamnogal_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF6">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06045">
        <property type="entry name" value="Rhamnogal_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="162" mass="18516" checksum="8DD7A6EB7CA27CC9" modified="2016-04-13" version="1">MGMDTSTSSFAMIHLGVILDNGLLKLKLSTPAGMIVAIHYNGTPNLLESGLKESQRGFVVVLEIKADHFSFDPPISNEQHNRRIHGTSFDLISKDENHIEVSFLKTWKYDNKDDPPIKVDKRYVMLRGCSGFYSYAIYQHLEEWPDIDIEQTRLAFKLDKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGJ4</accession>
    <name>A0A103YGJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001099">
        <property type="protein sequence ID" value="KVI08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGJ4"/>
    <dbReference type="STRING" id="59895.A0A103YGJ4"/>
    <dbReference type="Gramene" id="KVI08650">
        <property type="protein sequence ID" value="KVI08650"/>
        <property type="gene ID" value="Ccrd_012975"/>
    </dbReference>
    <dbReference type="OMA" id="TKDYIWQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="678" mass="76678" checksum="80D5B92615E33CBC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGY0</accession>
    <name>A0A103YGY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase, subunit VIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001079">
        <property type="protein sequence ID" value="KVI08904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGY0"/>
    <dbReference type="STRING" id="59895.A0A103YGY0"/>
    <dbReference type="Gramene" id="KVI08904">
        <property type="protein sequence ID" value="KVI08904"/>
        <property type="gene ID" value="Ccrd_012717"/>
    </dbReference>
    <dbReference type="OMA" id="FEAKHED"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit Via"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11138" checksum="221F5F6525D89D77" modified="2016-04-13" version="1">MASAMVRSSLRTALRGGVRVNPSSTRSFSSGASVEEEAREAAKWEKITYVGIVACSILAFVNLSKGHPHFDEPPPYPYLHIRNKEFPWGPDGLFEVKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHW0</accession>
    <name>A0A103YHW0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. PCMP-E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001062">
        <property type="protein sequence ID" value="KVI09419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHW0"/>
    <dbReference type="Gramene" id="KVI09419">
        <property type="protein sequence ID" value="KVI09419"/>
        <property type="gene ID" value="Ccrd_012180"/>
    </dbReference>
    <dbReference type="OMA" id="AYSQCGS"/>
    <dbReference type="OrthoDB" id="1929236at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000158">
        <property type="entry name" value="pentatricopeptide repeat-containing protein At2g33680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000396">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g36730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000205">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF372">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="697" mass="78174" checksum="F5771785933A2930" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIC1</accession>
    <name>A0A103YIC1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001050">
        <property type="protein sequence ID" value="KVI09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIC1"/>
    <dbReference type="SMR" id="A0A103YIC1"/>
    <dbReference type="STRING" id="59895.A0A103YIC1"/>
    <dbReference type="Gramene" id="KVI09656">
        <property type="protein sequence ID" value="KVI09656"/>
        <property type="gene ID" value="Ccrd_011956"/>
    </dbReference>
    <dbReference type="OMA" id="KMLNYNH"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="15576" checksum="4AB113152DA9B644" modified="2016-04-13" version="1">MVKFLKPNKAVVVLNGRFAGRKAVIVKQFDDGTRDRPYGHCLVAGIAKYPKKVIRKDSAKKTAKKSRVKAFIKLVNYNHIMPTRYTLDVDLKDVVSVDALQSRDKKVTACKETKARLEERFKTGKNRWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIY5</accession>
    <name>A0A103YIY5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_011669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="LEKV01001036">
        <property type="protein sequence ID" value="KVI09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIY5"/>
    <dbReference type="STRING" id="59895.A0A103YIY5"/>
    <dbReference type="Gramene" id="KVI09939">
        <property type="protein sequence ID" value="KVI09939"/>
        <property type="gene ID" value="Ccrd_011669"/>
    </dbReference>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009832">
        <property type="term" value="P:plant-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="270"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="51981" checksum="7F4D48AB719A0CE2" modified="2016-04-13" version="1">MVMVMVNLTIIRILLVSAIVSLTVRLILILTVCRSNRKRAVGFFHPYTNDGGGGERVLWCAVKAIQEEQPDLDCVIYTGDHDASPDSLIRRALDRFGVTLISPPKVVHLHKRKWIEETTYPRFTMIGQSFGSIYLSWEALNKFVPFYYLDTSGYAFTYPLARLFGCKVLCYTHYPTISLDMLSRVHSRSSMYNNDSVVANSFLLSQCKLVYYKFFSWMYGFVGSCANLALVNSSWTQSHIEKLWRIPDRIKRVYPPCDTTGLQALPLEREATPPKIISVAQFRPEKAHTLQLQAFAHSVKNLNADIPRPKLQFVGSCRNDADETRLQNLKDLAIKLKVEEDVEELVGLLGSATAGIHSMMDEHFGISVVEYMAAGAIPIAHNSAGPKMDIVLPEEGKQTGFLAETVEEYADAILKILRMSKSEKHEIAAAARRRASRFSEQRFYEDFRAAIRPIINHSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJD7</accession>
    <name>A0A103YJD7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETC complex I subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJD7"/>
    <dbReference type="STRING" id="59895.A0A103YJD7"/>
    <dbReference type="Gramene" id="KVI10184">
        <property type="protein sequence ID" value="KVI10184"/>
        <property type="gene ID" value="Ccrd_011432"/>
    </dbReference>
    <dbReference type="OMA" id="HRLKVCR"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="172" mass="19732" checksum="44F403B71C77F41F" modified="2016-04-13" version="1">MFLRRFARPSSLMMMAKVKETTGIVGLEVVPNAREVLIGLYDKTLKEIQRVPEDEGYRKAVESFTRHRLKVCQEEDDWETIEKRLGCGQVEELIEEAQDELKLIDKMIEWDPWGVEDDYECEVIENDAPVPKHVPLHRPGPLPEEFYKTLEAAMTGTPKATAKKDESTIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJG6</accession>
    <name>A0A103YJG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJG6"/>
    <dbReference type="STRING" id="59895.A0A103YJG6"/>
    <dbReference type="Gramene" id="KVI10193">
        <property type="protein sequence ID" value="KVI10193"/>
        <property type="gene ID" value="Ccrd_011413"/>
    </dbReference>
    <dbReference type="OMA" id="YWWGYES"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016530">
        <property type="term" value="F:metallochaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901562">
        <property type="term" value="P:response to paraquat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097501">
        <property type="term" value="P:stress response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="233"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="346"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49132" checksum="5E1FC7F3B6574B0D" modified="2016-04-13" version="1" fragment="single">MVKNNDLNQYDRSNLFTNSDQSSGDATHEYELELISDSSTMIEPVKHPPQQPLPTKSQDKLGLPERALSAAGAAFLSAIIVNPLDVAKVSLKLRSWVVQDHGNDLVFCIVVISQTRLQAQAAGVAYSHPMTNLTSRMAVFGPNMMFADLRCSPSCTRAGIHGTVSICPPDCFEYKGTLDVFGKIIRQEGVARLWRGTNAGLALAIPTVGIYLPCYDIFRNWFEEFAAQNAPSMTPYAPLLAGSLSRSLACTTCYPIELARTRMQAFKDFHSGKKAPGVWKTLLDVLSNVQRSENTRKNVQNYRALWTGLGAQLARDVPFSAICWSTLEPVRRSLLNLVGEEANAASVLGANFSAGFVAGSLAAAATCPLDVAKTRRQIERDPARALRMTTRQTLMEVWRDGGIRGLFTGAGPRVGRAGPSVGIVVSFYEVVKEYGRRMLVKRNLNSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKC7</accession>
    <name>A0A103YKC7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRAF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001004">
        <property type="protein sequence ID" value="KVI10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKC7"/>
    <dbReference type="STRING" id="59895.A0A103YKC7"/>
    <dbReference type="Gramene" id="KVI10674">
        <property type="protein sequence ID" value="KVI10674"/>
        <property type="gene ID" value="Ccrd_010921"/>
    </dbReference>
    <dbReference type="OMA" id="LIFPTRH"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF27">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATION UFD1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="90"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TRAFD1/XAF1 zinc finger" evidence="5">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="572" mass="63730" checksum="52873C19E8AD7D64" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKR9</accession>
    <name>A0A103YKR9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-acyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_010710</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01000986">
        <property type="protein sequence ID" value="KVI10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKR9"/>
    <dbReference type="STRING" id="59895.A0A103YKR9"/>
    <dbReference type="Gramene" id="KVI10889">
        <property type="protein sequence ID" value="KVI10889"/>
        <property type="gene ID" value="Ccrd_010710"/>
    </dbReference>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000300">
        <property type="entry name" value="S-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF101">
        <property type="entry name" value="PROTEIN S-ACYLTRANSFERASE 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="380"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="558" mass="61649" checksum="55D33F70D6A46B6D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKT8</accession>
    <name>A0A103YKT8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000976">
        <property type="protein sequence ID" value="KVI10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKT8"/>
    <dbReference type="STRING" id="59895.A0A103YKT8"/>
    <dbReference type="Gramene" id="KVI10929">
        <property type="protein sequence ID" value="KVI10929"/>
        <property type="gene ID" value="Ccrd_010670"/>
    </dbReference>
    <dbReference type="OMA" id="MHCWIPR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF7">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="376" mass="42774" checksum="C1BBD5F6252648CF" modified="2016-04-13" version="1" fragment="single">MAKLFSFTTLRDRWYRYFFSFSGLRSVSKDLGDGTIMHCWIPRTYRPSKPNLLLLHGFGANAMWQYADLLCHFTPKFNVFVPDLLFFGGSFTTRPERSESFQGKCVMKMMDDGFGVHRMSLVGISYGGFVGYSMCAEFPEAVEKLVVCCAGICLEEKDLTNGLFKVSDLEEAERILLAQTPEKLRELMKFSFVKPVKGIPNYFLSDFINNSKNPKINQVITAPILIPFSSTESCNMIYEYSLHDYAQNLIVTVLEKGLRYLLFISYPFVFKLSSSNVFFLLYIKQPTLIIWGEKDQIFPLILGERLERHIGENARLVVIGNAGHAVNFEKSKEFAKHLKDFLFDDSISSLSSSVSSLSSSISSLSNSLSFYSCREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL09</accession>
    <name>A0A103YL09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ppx/GppA phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_010575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000955">
        <property type="protein sequence ID" value="KVI11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL09"/>
    <dbReference type="STRING" id="59895.A0A103YL09"/>
    <dbReference type="Gramene" id="KVI11018">
        <property type="protein sequence ID" value="KVI11018"/>
        <property type="gene ID" value="Ccrd_010575"/>
    </dbReference>
    <dbReference type="OMA" id="RISEGCY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24006">
        <property type="entry name" value="ASKHA_NBD_PPX_GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048950">
        <property type="entry name" value="Ppx_GppA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21447">
        <property type="entry name" value="Ppx-GppA_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Ppx/GppA phosphatase C-terminal" evidence="3">
        <location>
            <begin position="347"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="546" mass="61171" checksum="454832F14FBABA6F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL70</accession>
    <name>A0A103YL70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000832">
        <property type="protein sequence ID" value="KVI11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL70"/>
    <dbReference type="STRING" id="59895.A0A103YL70"/>
    <dbReference type="Gramene" id="KVI11180">
        <property type="protein sequence ID" value="KVI11180"/>
        <property type="gene ID" value="Ccrd_010412"/>
    </dbReference>
    <dbReference type="OMA" id="KFVNDHG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055801">
        <property type="entry name" value="DUF7377"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF84">
        <property type="entry name" value="PROTEIN KINASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24093">
        <property type="entry name" value="DUF7377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="340"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="578" mass="63433" checksum="F4FD83575909F48B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLK0</accession>
    <name>A0A103YLK0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000326">
        <property type="protein sequence ID" value="KVI11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLK0"/>
    <dbReference type="STRING" id="59895.A0A103YLK0"/>
    <dbReference type="Gramene" id="KVI11346">
        <property type="protein sequence ID" value="KVI11346"/>
        <property type="gene ID" value="Ccrd_010245"/>
    </dbReference>
    <dbReference type="OMA" id="MAYPMKP"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="13652" checksum="43B5393A5D061470" modified="2016-04-13" version="1">MAYAAMKPTKPGLEEPQEQIHKIRITLSSKNVKNLEKVCADLVRGAKDKKLRVKGPVRMPTKVLNITTRKSPCGEGTNTWDRFELRVHKRVIDLFSSPDVVKQITSITIEPGVEVEVTIADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLZ9</accession>
    <name>A0A103YLZ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000114">
        <property type="protein sequence ID" value="KVI11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLZ9"/>
    <dbReference type="STRING" id="59895.A0A103YLZ9"/>
    <dbReference type="Gramene" id="KVI11482">
        <property type="protein sequence ID" value="KVI11482"/>
        <property type="gene ID" value="Ccrd_010108"/>
    </dbReference>
    <dbReference type="OMA" id="WINNGET"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF25">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="33612" checksum="7B5B859685925FB2" modified="2016-04-13" version="1" fragment="single">ISSNYLSPSSQPDELSVITIFQQSVEFITSASKSIFDMTGPTFLCILVFSERRGQWKAATQSQEFFRTLQRYYNNAYMDAEKQNAINVFLGHFQPQDGKPEVWELDSDQHFSAYRNGCSAVDKDGRSLHKKSLSDGNIIRESKLPTSSSNIGKSFACSALSDRSPGESKMIFGSKPEISTCDSGLTCSREPFGDLHNDGSLDEEKSHSVDCSNFVDLDWLSSSLNSCEEQLLGRSLFARSSMAGLSPENAANEIAAETTPSTSESSIKGSKHTAMESLCDDYDLPEEFSDSFLRWINNGETLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNN4</accession>
    <name>A0A103YNN4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_009212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000005">
        <property type="protein sequence ID" value="KVI12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNN4"/>
    <dbReference type="STRING" id="59895.A0A103YNN4"/>
    <dbReference type="Gramene" id="KVI12367">
        <property type="protein sequence ID" value="KVI12367"/>
        <property type="gene ID" value="Ccrd_009212"/>
    </dbReference>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000564">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="517"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="170"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="680"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="841"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1201" mass="138404" checksum="0732CE890BB14806" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118DCZ3</accession>
    <name>A0A118DCZ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011961">
        <property type="protein sequence ID" value="KVD98140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118DCZ3"/>
    <dbReference type="STRING" id="59895.A0A118DCZ3"/>
    <dbReference type="Gramene" id="KVD98140">
        <property type="protein sequence ID" value="KVD98140"/>
        <property type="gene ID" value="Ccrd_024200"/>
    </dbReference>
    <dbReference type="OMA" id="PCVGNDS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVD98140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="19027" checksum="8A57629382E3CE98" modified="2016-04-13" version="1" fragment="single">FTVIGCDDYAWLTSETNSRYVSTGCATRCPTPKDVVGDKCLGNGCCQSSISKDINYYTTRVYSMDESYNMSYTRSFNPCTYAFVGEENVFKFNGATDLNNTSLKKKIEANVPIVLDWAIGNLSCTEAEATDGFACRYSNSSCVNSPRESGGYRCICSEGYEGNPYLSPGCQGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I7R6</accession>
    <name>A0A118I7R6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ascorbate oxidase</fullName>
            <ecNumber evidence="5">1.10.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_026124</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 L-ascorbate + O2 = 4 monodehydro-L-ascorbate radical + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30243"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="EC" id="1.10.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.3" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01007468">
        <property type="protein sequence ID" value="KVG89796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I7R6"/>
    <dbReference type="STRING" id="59895.A0A118I7R6"/>
    <dbReference type="Gramene" id="KVG89796">
        <property type="protein sequence ID" value="KVG89796"/>
        <property type="gene ID" value="Ccrd_026124"/>
    </dbReference>
    <dbReference type="OMA" id="WHSHTEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008447">
        <property type="term" value="F:L-ascorbate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13845">
        <property type="entry name" value="CuRO_1_AAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13893">
        <property type="entry name" value="CuRO_3_AAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000059">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000060">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034259">
        <property type="entry name" value="CuRO_1_AAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034267">
        <property type="entry name" value="CuRO_3_AAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017760">
        <property type="entry name" value="L-ascorbate_oxidase_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03388">
        <property type="entry name" value="ascorbase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159315" description="L-ascorbate oxidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="164"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="442"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVG89796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="584" mass="65337" checksum="EE7623E591AD88C0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118IIC2</accession>
    <name>A0A118IIC2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anticodon-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007081">
        <property type="protein sequence ID" value="KVH19090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118IIC2"/>
    <dbReference type="STRING" id="59895.A0A118IIC2"/>
    <dbReference type="Gramene" id="KVH19090">
        <property type="protein sequence ID" value="KVH19090"/>
        <property type="gene ID" value="Ccrd_025906"/>
    </dbReference>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="83"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH19090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="303" mass="35026" checksum="AD7F95A6DD0DBCAD" modified="2016-04-13" version="1">MLRRNVRLRREYLYRKSLEGKERLLYEKKRKIKQALEEGKPIPTELRNEDAALRQEIDLEDERTAVPRSTIDDEYANANERDPKILLTTSHDPSAPLKQFVKSYCAEKQIFNGSYLQELKLVFPNSQRMNRGGQVISEIIETCRAHDFTDVILVYEHRGVPDKIVISHLPFGPTAYFQILNVVTRHDNKDKKEMGTVSEAYPHLILNNFSTKIGERTANILKHLFPVPKPDSKRIITFANQADYISFRQSGGPKSIDLKEVGPRFELRLYQIKLGTVDQEEAQTEWVLRSFINTSKKQKVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS12</accession>
    <name>A0A118JS12_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005795">
        <property type="protein sequence ID" value="KVH87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH87819">
        <property type="protein sequence ID" value="KVH87819"/>
        <property type="gene ID" value="Ccrd_024870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="34" mass="4018" checksum="EDA2F0EE50BC36F0" modified="2016-04-13" version="1">MNSHSRVERIPPSXQKPRFFISICNPFYSFLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUE6</accession>
    <name>A0A118JUE6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005080">
        <property type="protein sequence ID" value="KVH91077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUE6"/>
    <dbReference type="Gramene" id="KVH91077">
        <property type="protein sequence ID" value="KVH91077"/>
        <property type="gene ID" value="Ccrd_006908"/>
    </dbReference>
    <dbReference type="OMA" id="VEVNTHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF195">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="48812" checksum="28C7836CCCC68137" modified="2016-04-13" version="1" fragment="single">MVHLPNLKVLNLSNSEKLIRTPDFDGLPCLERLLLFRCNQLTDVHPSIGYHERLIYVDMRCCTHLKKFPPIRGMKKLETLLLSWCLQLCMFPEIQTNMDNMVELSLDRTGIKVIPSSFGKYCINLLSLSLGYCGSLESIEGNFHHLKHLKKFSIARCKKLKIPPEGLFDVTCCLEVLNLFGTSFKNLHPGIVSMKFLGFPPSLRMLGLRSCNWINGDISSVLCELSNLHVLDLQKNDFSRLCCNLLQLCSLKVLNLSYCYDLVELPDIPSSIAVLKAYGCKKLKLVDLPTDLKWLWIISLPMNCILGDMERKVQSMFQGNSIYDNSISLSFHGDNIQLEDFARRRLMLELPRNWYNEFSGFLICVNRIFDNMSHVITIEDVMGRENEDVLEVSDGTPKDIWGEFVEAYLMVEVNTHYHFIFHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWJ9</accession>
    <name>A0A118JWJ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004558">
        <property type="protein sequence ID" value="KVH94330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWJ9"/>
    <dbReference type="STRING" id="59895.A0A118JWJ9"/>
    <dbReference type="Gramene" id="KVH94330">
        <property type="protein sequence ID" value="KVH94330"/>
        <property type="gene ID" value="Ccrd_003617"/>
    </dbReference>
    <dbReference type="OMA" id="HANYVSE"/>
    <dbReference type="OrthoDB" id="780709at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052426">
        <property type="entry name" value="Plant_dev_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801">
        <property type="entry name" value="OS07G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801:SF117">
        <property type="entry name" value="OS07G0417400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="201" mass="22981" checksum="383852CCEC3CEE3A" modified="2016-04-13" version="1">MESIATDDHDEDDQPTNSSDQEIDQDDHVLGTNHGGRSYECVFCKRGFTTAQALGGHMNIHRKDRAKNSNRSSYSSSNNRSSNYKQDDDDHGCYSGPRFFQPVFASYPPSYLSATPANHHQEGRQLHYFSSTSGDLRPMNYENNHQDHDQVITSASREEERRRISLQFGWSNAEDEDSERRIRGGDKQDELDLELRLGHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWP5</accession>
    <name>A0A118JWP5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004398">
        <property type="protein sequence ID" value="KVH95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWP5"/>
    <dbReference type="Gramene" id="KVH95141">
        <property type="protein sequence ID" value="KVH95141"/>
        <property type="gene ID" value="Ccrd_002784"/>
    </dbReference>
    <dbReference type="OMA" id="HWMIEDG"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="618" mass="71102" checksum="ED723B29B88E4C03" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXG1</accession>
    <name>A0A118JXG1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Voltage-dependent anion-selective channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXG1"/>
    <dbReference type="STRING" id="59895.A0A118JXG1"/>
    <dbReference type="Gramene" id="KVH96127">
        <property type="protein sequence ID" value="KVH96127"/>
        <property type="gene ID" value="Ccrd_001797"/>
    </dbReference>
    <dbReference type="OMA" id="GCQMAYE"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000003">
        <property type="entry name" value="Outer mitochondrial membrane protein porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="29208" checksum="0128B5692CBEA3D3" modified="2016-04-13" version="1">MGKGPGLYPDIGKKARDLLYKDYQSDHKFSLTTYTANGVAITASGAKKGELILADVNTKLINKNITTDVKVDTNSKLCTTITIDEPAPGLKTIFSFVVPDQRSGKVELQYLHEYAGISTSIGLTASPIVNFSGVAGNNTVALGTDVSFDTASGNFTKYNAALSFSTSDLIASLTLNDKADSVTASYYHTVSPLTNTAVGAELSHGFSSNENSLTIGTQHSLDPLTTVKARVNNSGIASALLQHEWRPKSLFTISGEVDTRAIEKSAKVGLALALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXJ0</accession>
    <name>A0A118JXJ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rubisco LS methyltransferase, substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class V-like SAM-binding methyltransferase superfamily. Plant protein-lysine LSMT methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004352">
        <property type="protein sequence ID" value="KVH96162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXJ0"/>
    <dbReference type="STRING" id="59895.A0A118JXJ0"/>
    <dbReference type="Gramene" id="KVH96162">
        <property type="protein sequence ID" value="KVH96162"/>
        <property type="gene ID" value="Ccrd_001749"/>
    </dbReference>
    <dbReference type="OMA" id="QHIDGIF"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030785">
        <property type="term" value="F:[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19179">
        <property type="entry name" value="SET_RBCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000005">
        <property type="entry name" value="Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1420.10:FF:000004">
        <property type="entry name" value="Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011192">
        <property type="entry name" value="Rubisco_LSMT_MeTrfase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044431">
        <property type="entry name" value="SET_RBCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF113">
        <property type="entry name" value="[FRUCTOSE-BISPHOSPHATE ALDOLASE]-LYSINE N-METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009328">
        <property type="entry name" value="RMT_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51583">
        <property type="entry name" value="SAM_MT127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="53"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR009328-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="478" mass="54595" checksum="F6813360EFEAC0B1" modified="2016-04-13" version="1">MATFFSTVFSSPNPLRSKSILHYNQQLTVKCNAAAAPPLPTEVRTFWKWLCDEKVVSSTSPAKPGTVPEGLGLVAERDIGRNEVILEMPKKFWINPDTVSASEIGKVCNGLKPWISVALFLIREKLREENDYSPWRNYIDILPEYTDSTIFWSEEELCEIEGTQLLSTTLSVKEYVKNEFLQVQEQVILPNKRLFPFVVTFEDFIWAFGILRSRAFSRLRGQNLVLIPLADLINHSPSITTEDYAYEIKGAGLFSRDQIFSLRTPIPVKAGQQVLIQYDLNKSNAELALDYGFIESTPDRNTYTLTLQISDSDPYFDDKLDIAESNGTKAVQYFDITLGRPLPPKMLPYLRLVALGGTDAFLLESIFRNSVWDHLELPVSRDNEEVICQVVRSACQSALSSYRTTIEEDEKLKGGDLDRRVEIAVGIRSGEKMVLQHIDGIFKEREMELDEYEYYQERRLRDLGLVGEQGDIIFWEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXV8</accession>
    <name>A0A118JXV8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003818">
        <property type="protein sequence ID" value="KVH97794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXV8"/>
    <dbReference type="Gramene" id="KVH97794">
        <property type="protein sequence ID" value="KVH97794"/>
        <property type="gene ID" value="Ccrd_000074"/>
    </dbReference>
    <dbReference type="OMA" id="YNKEESC"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38186" checksum="8AEFF8E2EC572832" modified="2016-04-13" version="1">MADTTALSYWLNWRFFLCALWVLIAIIAAVILILKYEVFNKKRCRQRDNEADIEPIGILYEDETWRTSLKGMHPGWLLAYRLIAFSILLALLISNLVIGGARVLFFYTQWTFALVTFYFGLASSLSIYGCYQYWNEVGDDNINRVGLDTEQGTFTAPLIEHSLASQHLPTEPSKHEEINVRKTAGTWGYFFQIVFQICAGSVGLTDTVFWLIIYPFLTPLTYKLNFLNVSLHSINAVLLLIEVILNRLRFPFFRLAYFALWTCTFVIFQWILHACVSMWWPYAFLDLSSPYAPIWYLGVGLIHLPAFGIFALIVMWKQLLFSRFSQNLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYF4</accession>
    <name>A0A118JYF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003794">
        <property type="protein sequence ID" value="KVH98499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYF4"/>
    <dbReference type="STRING" id="59895.A0A118JYF4"/>
    <dbReference type="Gramene" id="KVH98499">
        <property type="protein sequence ID" value="KVH98499"/>
        <property type="gene ID" value="Ccrd_023277"/>
    </dbReference>
    <dbReference type="OMA" id="PADEYWK"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF228">
        <property type="entry name" value="PROTEIN IMPAIRED IN BABA-INDUCED STERILITY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="685" mass="76372" checksum="91A70F2042F2E207" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYR0</accession>
    <name>A0A118JYR0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYR0"/>
    <dbReference type="STRING" id="59895.A0A118JYR0"/>
    <dbReference type="Gramene" id="KVH98197">
        <property type="protein sequence ID" value="KVH98197"/>
        <property type="gene ID" value="Ccrd_023592"/>
    </dbReference>
    <dbReference type="OMA" id="EWDEDSQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF38">
        <property type="entry name" value="D111_G-PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="438" mass="48052" checksum="FE2934002EFF7C58" modified="2016-04-13" version="1" fragment="single">MSNPMPLHLESGIYLFGENSGFYHDPAAGWYYSSKDGLYYKFENGNYADQSNANEGIVTSVGDNSIHDESYDHAPCGKDPTDVNFEGGESEGYVAEEATPSDPIDTLIELYLSGYSNQTIDDASGARTFDDHTSLNIPTDGIDDVDADELEEGEWIPDDTHEAVDGRGGASDEDDFAEEEMWRAQYGQAIQSDKKLVPDQPIMDLWDWAMITGTKKRGKRRICRLVGRLVRRSTKLHPSMPSSGRVLKTAPICEVLLDLVRVRSGRVYKLRSPKVAYLASLSSYDSSNPTKDWGFPELSTDKVTQTVAKSCQEIEPKRERVRLKGHAYRDRAAERRSLHGGFGVGPGQKRTADTDSSSSSPVSATPEEAVAEALNLSFGVGSYARKILEGMGWKEGEALGCGMKGLTEPIQAVGNKGSSGIKECHLQQFVLAKTKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ62</accession>
    <name>A0A118JZ62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ62"/>
    <dbReference type="STRING" id="59895.A0A118JZ62"/>
    <dbReference type="Gramene" id="KVH98952">
        <property type="protein sequence ID" value="KVH98952"/>
        <property type="gene ID" value="Ccrd_022852"/>
    </dbReference>
    <dbReference type="OMA" id="VATTYDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46284">
        <property type="entry name" value="PROTEIN KINESIN LIGHT CHAIN-RELATED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46284:SF5">
        <property type="entry name" value="PROTEIN KINESIN LIGHT CHAIN-RELATED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="657" mass="72633" checksum="254F76DDF02CFFE3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZA3</accession>
    <name>A0A118JZA3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003414">
        <property type="protein sequence ID" value="KVH99774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZA3"/>
    <dbReference type="STRING" id="59895.A0A118JZA3"/>
    <dbReference type="Gramene" id="KVH99774">
        <property type="protein sequence ID" value="KVH99774"/>
        <property type="gene ID" value="Ccrd_022013"/>
    </dbReference>
    <dbReference type="OMA" id="QVGNHGA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="383" mass="43019" checksum="BD5AC05D4CDE433E" modified="2016-04-13" version="1">MIHMGFSGAVAFFLVRVFKVVAPVKMTFEIYATCVIPISAFFASSLCSLIMKMDTVPVATLIMAVLCGTDKLRWEVFLNMLLVSVGVVISSYGEIHFNVIGTLYQVTGIFAEALRLVLTQVLLQKKGLTLNPITSLYYIAPCRYWTTMLANISLLFYVDKFCLSDVSFPKFSFPGCFGFLKKKQFVYCLLFLMINYKWSSSNSFAFLFVPWYFLEKTDMEVSQIQFNFWIFFSNAICALALNFSIFLVLARTGAVTIRVAGVLKDWILIALSTVIFPESAITGLNIIGYAIALCGVVMYNYIKVKDVKASQLPPESIPERLTKDWRLEKKSSDVFVPDNNIKDDARSSRFGSTSDTNVDEEAPLMASSRLSYIGRSQLSSRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0X1</accession>
    <name>A0A118K0X1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002670">
        <property type="protein sequence ID" value="KVI01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0X1"/>
    <dbReference type="Gramene" id="KVI01948">
        <property type="protein sequence ID" value="KVI01948"/>
        <property type="gene ID" value="Ccrd_019771"/>
    </dbReference>
    <dbReference type="OMA" id="DHMPNRN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000503">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF353">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="8">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="542" mass="61874" checksum="E33D8459F9F97F1A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K113</accession>
    <name>A0A118K113_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_019896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002682">
        <property type="protein sequence ID" value="KVI01815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K113"/>
    <dbReference type="STRING" id="59895.A0A118K113"/>
    <dbReference type="Gramene" id="KVI01815">
        <property type="protein sequence ID" value="KVI01815"/>
        <property type="gene ID" value="Ccrd_019896"/>
    </dbReference>
    <dbReference type="OMA" id="IWHAVAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF8">
        <property type="entry name" value="POTASSIUM TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="106"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="13">
        <location>
            <begin position="505"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI01815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="741" mass="82821" checksum="C8A24D0BD22BECFE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K1G4</accession>
    <name>A0A118K1G4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_018844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K1G4"/>
    <dbReference type="STRING" id="59895.A0A118K1G4"/>
    <dbReference type="Gramene" id="KVI02835">
        <property type="protein sequence ID" value="KVI02835"/>
        <property type="gene ID" value="Ccrd_018844"/>
    </dbReference>
    <dbReference type="OMA" id="PERKYIE"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="260"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="493" mass="56007" checksum="251F94D36A45E387" modified="2016-04-13" version="1">MASRNFPAMPTPSSLLSAYASMSTSIMLFRTMFDQFFPRQLRRYVVDAVRFYWKPKSSKLTLIFDEKDGMTSNHMFDAAEAYLCTRINPDSDRLRITKNVKEKHINIKFAESEELVDSFEGISLTWKYISQQPQQRSGSGGGYDFGQNGGKSSSGGSFTPERKYIELKFDKKHKEIIISAYLPSVLKKFQELENQKKVVKLHNLQSYGGGPGGFKESVNLDHPSTFDTLAMDLKMKKAIIDDLNLFLTRRDFYKKVGKAWKRGYLLYGPPGTGKSSLIAAIANYLKFDIYDLQLMNVGSDSSLKKLMLRTSNRSILVIEDIDCSIQLPDRKGTAPAKISDGRSIRDSQFSLSGLLNFIDGLWSCCGDERIIIFTTNHKERLDPALLRPGRMDVHIHMSYLTIDGFKTLAANYLDIHDYHRSFREINELISCTKVTPAEVAEELMKSNNVELVLEGLVKFLKRKRTRDEETKEGIDNGDDGVHEDKRAKTLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2D7</accession>
    <name>A0A118K2D7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002299">
        <property type="protein sequence ID" value="KVI04200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2D7"/>
    <dbReference type="Gramene" id="KVI04200">
        <property type="protein sequence ID" value="KVI04200"/>
        <property type="gene ID" value="Ccrd_017498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1111">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="85" mass="9693" checksum="D671682731C4F9C1" modified="2016-04-13" version="1">MLQTDDSERRSIDLIHLEHSREDNIEGTGVPFFEFESILAATDNFSDANKLGEGGFGPVYKVMIPNLKQVLLISMVSFLKEYKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3V8</accession>
    <name>A0A118K3V8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001813">
        <property type="protein sequence ID" value="KVI06512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3V8"/>
    <dbReference type="STRING" id="59895.A0A118K3V8"/>
    <dbReference type="Gramene" id="KVI06512">
        <property type="protein sequence ID" value="KVI06512"/>
        <property type="gene ID" value="Ccrd_015138"/>
    </dbReference>
    <dbReference type="OMA" id="QFMNPIS"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="257" mass="29289" checksum="D771EF8902F24486" modified="2016-04-13" version="1">MGPKKGGKPVATKKKTEKVVNPLFEKRPKQFGIGGALPPKKDVHRFVRWPQVVRIQRKRRILKQRLKVPPALNQFTKTLDKNLATTLFKMLLKYRPEDKAAKKERLLKRAQAESEGKTAEAKKPIVVKYGLNHVTYLIEQNKAQLVIIAHDVDPIELVVWLPALCRKMEIPYCIVKGKSRLGTIVHQKTAAALCLTTVKNEDKMEFSRILEAIKANFNDKYEEYRKKWGGGIMGSKSQAKTKAKERVLAKEAAQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K457</accession>
    <name>A0A118K457_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_014648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001534">
        <property type="protein sequence ID" value="KVI06973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K457"/>
    <dbReference type="STRING" id="59895.A0A118K457"/>
    <dbReference type="Gramene" id="KVI06973">
        <property type="protein sequence ID" value="KVI06973"/>
        <property type="gene ID" value="Ccrd_014648"/>
    </dbReference>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="504467at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI06973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="112" mass="12986" checksum="69D57549F4692A89" modified="2016-04-13" version="1">MVKGRQGERVRLYTRGTILGYKRSKSNQYPNTSLIQIEGVNTKEEVSWYQGKRMAYIYKAKVKRNGSHYRCIWGKVTRPHGNTGIVRAKFKSNLPPKSMGSRVRVFMYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K465</accession>
    <name>A0A118K465_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001532">
        <property type="protein sequence ID" value="KVI07008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K465"/>
    <dbReference type="Gramene" id="KVI07008">
        <property type="protein sequence ID" value="KVI07008"/>
        <property type="gene ID" value="Ccrd_014636"/>
    </dbReference>
    <dbReference type="OMA" id="RWISANT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF35">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="1">
        <location>
            <begin position="470"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="565" mass="62518" checksum="1AC2D95DFE674C7E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4Q0</accession>
    <name>A0A118K4Q0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_013771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001479">
        <property type="protein sequence ID" value="KVI07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4Q0"/>
    <dbReference type="Gramene" id="KVI07863">
        <property type="protein sequence ID" value="KVI07863"/>
        <property type="gene ID" value="Ccrd_013771"/>
    </dbReference>
    <dbReference type="OMA" id="EMGTIPH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF37">
        <property type="entry name" value="INACTIVE PROTEIN KINASE SELMODRAFT_444075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="102"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="36663" checksum="2B3D476AD2B5944E" modified="2016-04-13" version="1" fragment="single">MKTEMGTIPHAARWSVDLRQLGERKRDQNESGKVATRRVSFSHANKPTIDRISSVRRDMSLSLKRPPMPPPLCSVCKLSAPVLGRSPRRFSYEEIERATDGFSANNFLAEGGYGQVYRGILSDGQVVAVKQRKMVSAQGAAEFCSEVEVLSCAQHKNLVMLIGYCIEKEWLLVYEYACNGSLDKHLYSKGLSLTPSLAFQYKMKVACGAARGLRYLHEDCRVGCIVHRDFRPNNILLTHDFEPMVSHPLVGDFGLARWQADGRLEEETRRSRLFVEGKGCVEMIDPKLDNKYDTKEAECMMHAASLCISPHPEQRPRMSKPHSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K745</accession>
    <name>A0A118K745_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000051">
        <property type="protein sequence ID" value="KVI11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K745"/>
    <dbReference type="STRING" id="59895.A0A118K745"/>
    <dbReference type="Gramene" id="KVI11703">
        <property type="protein sequence ID" value="KVI11703"/>
        <property type="gene ID" value="Ccrd_009884"/>
    </dbReference>
    <dbReference type="OMA" id="WDGACER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000049">
        <property type="entry name" value="uncharacterized protein LOC103698197 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="35808" checksum="55F5D61AC3CE5FDB" modified="2016-04-13" version="1">MSVSLTVMTFNLLEDQPEDGPNCWEKRKDLCVSVITSYSPIILCTQQGVKSQLEYLQQCLPVQQTDLQHMSVSFILARVIIPPSSGYDQFGISRKGSEDVSDQHCTIFYDKEKVELLEGGTFWLSESPSVPGRVEAPGFSFQIVNTNMDEFSPRARRRSALLTWQHIASLPPSLPVAYCGGFNTQKESTTGRFLLGRSREHGVVGDMRDAWPNARLRKNMSLIRTYHGFKGNKQGAVEFLKLIFRALCLCWDRQTQDLHIDWILFRGRSLIPVSCEVVSDNIDGHYPSSNYPIFAEFMLPRTVRLLDPPPAEEMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7L6</accession>
    <name>A0A118K7L6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HR-like lesion-inducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000003">
        <property type="protein sequence ID" value="KVI12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7L6"/>
    <dbReference type="STRING" id="59895.A0A118K7L6"/>
    <dbReference type="Gramene" id="KVI12408">
        <property type="protein sequence ID" value="KVI12408"/>
        <property type="gene ID" value="Ccrd_009194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008637">
        <property type="entry name" value="HR_lesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474">
        <property type="entry name" value="HR-LIKE LESION-INDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474:SF9">
        <property type="entry name" value="HR-LIKE LESION-INDUCING PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05514">
        <property type="entry name" value="HR_lesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="192" mass="21324" checksum="FF7A3D8FF685EB2E" modified="2016-04-13" version="1">MTATFTKIRSLVDSSTLEASSRVLIQSEWGSHCSSADFSLLLSSYYLLINCRYHEFGTDGGPAVKVLEPKLNVFTKLITSKVGIQVPEIDTKHVVLAAIVLKGFGGVGFIFGSYAGSILLVLHQLIFTPVLYDFYNYDVEDTEFEYGFAGSIAIFHRDETLDIPAATTKDFEDENELGMFFYQLPLSGYVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S9K1</accession>
    <name>A0A124S9K1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006375">
        <property type="protein sequence ID" value="KVH84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124S9K1"/>
    <dbReference type="STRING" id="59895.A0A124S9K1"/>
    <dbReference type="Gramene" id="KVH84625">
        <property type="protein sequence ID" value="KVH84625"/>
        <property type="gene ID" value="Ccrd_025446"/>
    </dbReference>
    <dbReference type="OMA" id="GGHTHEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009788">
        <property type="term" value="P:negative regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001366">
        <property type="entry name" value="Zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044246">
        <property type="entry name" value="ZFP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287">
        <property type="entry name" value="C2H2 AND C2HC ZINC FINGERS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR C2H2 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="31979" checksum="50E39E39AEEC955E" modified="2016-04-13" version="1">MAAARSIPAPIRHDGARVKTCEVINKLLFAMMLSKSIDLELEVQEDDDSDISSQVDSNISVQNTFPSRVTDSLKIPKTSQTTYDPISLELSLSFNSNTEKFEPRNSMGSSISTTSKSTNEIESQTTPGTLPRVFPCNYCQRKFFSSQALGGHQNAHKRERMLAKRTMRMGIFSERYAGQLATFPLHGTSLRSLEIKAHSSQHQTFVPPVMRMPPVISSMSPRHAIGFMGLAIHVEDDGHDQLLWPGSFRQVAATGAGVDSLAETSEMNTMEGFRQVYDGHATPDLTLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB54</accession>
    <name>A0A124SB54_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005197">
        <property type="protein sequence ID" value="KVH89576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB54"/>
    <dbReference type="STRING" id="59895.A0A124SB54"/>
    <dbReference type="Gramene" id="KVH89576">
        <property type="protein sequence ID" value="KVH89576"/>
        <property type="gene ID" value="Ccrd_008431"/>
    </dbReference>
    <dbReference type="OMA" id="QTNEWNE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF67">
        <property type="entry name" value="LYSINE KETOGLUTARATE REDUCTASE TRANS-SPLICING-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="19899" checksum="9C070CD162B0F61A" modified="2016-04-13" version="1" fragment="single">WVWVRLGGISVAVAFTGLKGLPYGIIEANSDLELKPLWSASSSKLKVISSSLANVPHPHNLLAMPVGLKQKQNVNTIVRKFLKENFTIILFHYDGKMDEWWDLKWCNKAIHIVAENQTKWWFAKRFLHPAAVSIYDYVFLWDEDLGVQHFNPKRSLYDPKGSTKCSSTSVGPPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCQ8</accession>
    <name>A0A124SCQ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. AP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004547">
        <property type="protein sequence ID" value="KVH94570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCQ8"/>
    <dbReference type="STRING" id="59895.A0A124SCQ8"/>
    <dbReference type="Gramene" id="KVH94570">
        <property type="protein sequence ID" value="KVH94570"/>
        <property type="gene ID" value="Ccrd_003359"/>
    </dbReference>
    <dbReference type="OMA" id="TSHGHPN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000004">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF118">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH94570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="512" mass="55604" checksum="2F54ABF2FD3DCA66" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD28</accession>
    <name>A0A124SD28_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cysteine peptidase, asparagine active site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004380">
        <property type="protein sequence ID" value="KVH95650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD28"/>
    <dbReference type="STRING" id="59895.A0A124SD28"/>
    <dbReference type="Gramene" id="KVH95650">
        <property type="protein sequence ID" value="KVH95650"/>
        <property type="gene ID" value="Ccrd_002261"/>
    </dbReference>
    <dbReference type="OMA" id="FRMQRGI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000023">
        <property type="entry name" value="Senescence-specific cysteine protease SAG39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="368" mass="41613" checksum="D159C4ECEC532DFE" modified="2016-04-13" version="1" fragment="single">IIPSITNPTFSSLYKVTQVDLLYQIIQQRWLNMETRKVFFVALSFVLFIGVANCIDFTEKDLATDESLWDLYERWRSHHTVSKDLGEKIKRFNVFKYNVNYIHKVNQMDKPYKLKLNKFADMTNHEFRSGFDSKILHFRMLQGERRRTPFMHEKTSDPPPSIDWRKNGAVNPVKNQGRCGSCWAFSTIVGVEGINKIKTNKLVSLSEQELVDCESDNQGCDGGLMENAYKFIEENGGRNSPIVKIDGFETVPANDESALLKAVANQPVSIAIDASGPNFQFYSEGVFNGFCGTELDHGVAIVGYGTTQEGIGYWIVRNSWGPEWGEQGYIRMQRGINSPEGLCGLAMEASYPIKVSSDNPRSVAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEM1</accession>
    <name>A0A124SEM1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003382">
        <property type="protein sequence ID" value="KVI00511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEM1"/>
    <dbReference type="STRING" id="59895.A0A124SEM1"/>
    <dbReference type="Gramene" id="KVI00511">
        <property type="protein sequence ID" value="KVI00511"/>
        <property type="gene ID" value="Ccrd_021238"/>
    </dbReference>
    <dbReference type="OMA" id="KYRDEEC"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044517">
        <property type="entry name" value="PHOX1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46183:SF12">
        <property type="entry name" value="PB1 DOMAIN, TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46183">
        <property type="entry name" value="PROTEIN CLMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="715" mass="82625" checksum="CA410E7BEC74ED0E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEW9</accession>
    <name>A0A124SEW9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="2">HIB-CoA hydrolase</shortName>
            <shortName evidence="2">HIBYL-CoA-H</shortName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01003101">
        <property type="protein sequence ID" value="KVI01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEW9"/>
    <dbReference type="STRING" id="59895.A0A124SEW9"/>
    <dbReference type="Gramene" id="KVI01413">
        <property type="protein sequence ID" value="KVI01413"/>
        <property type="gene ID" value="Ccrd_020317"/>
    </dbReference>
    <dbReference type="OMA" id="IDDEDWQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF6">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="18558" checksum="BC55511EA61C69CD" modified="2016-04-13" version="1">MGGGAGLSMNATFRIVTENTLFAMPEASIGCIPDVGASNFLSRLPGYFGEYVALTQVRLNGIEMVECGLATHLIREGRLQKLDECLAREHLVVSHLLRRTVNDDFYEGPRAVLIDKDKKPKWSPSKLALVDQEMLSKCFSMIDDEDWQPLKLLARTNPNHVILSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF87</accession>
    <name>A0A124SF87_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF87"/>
    <dbReference type="STRING" id="59895.A0A124SF87"/>
    <dbReference type="Gramene" id="KVI02503">
        <property type="protein sequence ID" value="KVI02503"/>
        <property type="gene ID" value="Ccrd_019257"/>
    </dbReference>
    <dbReference type="OMA" id="NNKPKAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF50">
        <property type="entry name" value="COPINE (CALCIUM-DEPENDENT PHOSPHOLIPID-BINDING PROTEIN) FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="45177" checksum="A08D4212BE2A19E4" modified="2016-04-13" version="1">MGGSSSREERARYRHSSSFQSSSSFSGNQYGGHPPQPSYSFPAQRDENYPAQEVTEALAHAGLESSNLIVGIDFTKSNEWTGSRSFHRKSLHHIGDSLNPYEQAISIIGKTLAAFDEDNLIPCYGFGDASTHDQDVFSFYPEDRFCNGFEDVMSRYREIVPRLKLSGPTSFAPVIEQAMTIVEQSGGQYHVLLIIADGQVTRSVDTEYGQLSPQEQNTVDAIVEASKLPLSIVLVGVGDGPWDMMKEFDDNIPDRDFDNFQNMPLIRKETEFALSALMEIPSQYKATIELNLLGSRRGISPQRVALPPPIRPPFSKPSYSNSFQKGSQSYYGHGSPVRSASLYGQISPDHTSASISKSTSDNQLCPICLNNTKNMAFGCGHQTCYECGETLQLCPICRSSIQTRIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFB9</accession>
    <name>A0A124SFB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002645">
        <property type="protein sequence ID" value="KVI02686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFB9"/>
    <dbReference type="STRING" id="59895.A0A124SFB9"/>
    <dbReference type="Gramene" id="KVI02686">
        <property type="protein sequence ID" value="KVI02686"/>
        <property type="gene ID" value="Ccrd_019023"/>
    </dbReference>
    <dbReference type="OMA" id="DGMSEPK"/>
    <dbReference type="OrthoDB" id="641808at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="174" mass="19380" checksum="737FFCA29A4C6F20" modified="2016-04-13" version="1">MPPPHPLAAAPPPPPPSPLYKHKSWSPDILRDEEWLKRKDKHYQRYRRRNKSVTDEDIDELKACIELGFGFDESNDRLSSTLPALGLYYTVNKQYHDTISKSSSMSSSSSSSVSSYSSSVSESDLFSPSENPRAAVFSRGDDPQTMKTRLRQWAQVVACSLRQSSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFK9</accession>
    <name>A0A124SFK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_018132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002342">
        <property type="protein sequence ID" value="KVI03571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI03571">
        <property type="protein sequence ID" value="KVI03571"/>
        <property type="gene ID" value="Ccrd_018132"/>
    </dbReference>
    <dbReference type="OMA" id="ILMNDAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF61">
        <property type="entry name" value="NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176225" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="185"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="438"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="699"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI03571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137643" checksum="9F3F38FFCFCB137E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGZ3</accession>
    <name>A0A124SGZ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_013679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001454">
        <property type="protein sequence ID" value="KVI07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGZ3"/>
    <dbReference type="Gramene" id="KVI07951">
        <property type="protein sequence ID" value="KVI07951"/>
        <property type="gene ID" value="Ccrd_013679"/>
    </dbReference>
    <dbReference type="OMA" id="DTMRNSK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF207">
        <property type="entry name" value="OS07G0188700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="6">
        <location>
            <begin position="100"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="49836" checksum="E8A41336A1E2C33F" modified="2016-04-13" version="1" fragment="single">MDQDDNFTATLNGSDIFLRTNETYDPPSSTGIQRNFSGIDKLEASLMQARAAIRETISQNQINDPDYTPFEWLFTALLHSLPIGFELKRHGGDCRSYLEMEKRFKVYVYEEGEPPIFHNGPCKSIYAMEGNFIFQMETTKLFRTRDPDKAHIFFLPMSSTMMVRFILERGSRDHWRPMKRTVKDYVDLVASKYPFWNRSLGADHFIVACHDWAVPNLFTNSIRAFCNANTSEGFKPSKDVSIPEILLRDGTMQGLVGGPSPRQRHILAFFAGGVHGPIRPILLEHWENKDPDVQVHKYLPKGVSYIDMLRQSKYCISPSGYEVASPRMVEALYTGCVPVLIKDHYVAPFSDVLNWKSFAVIIPVEDIPNLKKILMGISTRQYLRMQRRGKQVKRHFEVNYPPKRYDVFHMILHSVWLRRLNAPYWGTYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHP6</accession>
    <name>A0A124SHP6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_011439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001027">
        <property type="protein sequence ID" value="KVI10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHP6"/>
    <dbReference type="STRING" id="59895.A0A124SHP6"/>
    <dbReference type="Gramene" id="KVI10187">
        <property type="protein sequence ID" value="KVI10187"/>
        <property type="gene ID" value="Ccrd_011439"/>
    </dbReference>
    <dbReference type="OMA" id="PRITHQD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000035">
        <property type="entry name" value="Putative receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052232">
        <property type="entry name" value="RLK_Ser/Thr-Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984:SF39">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="128"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="404" mass="46382" checksum="C7E03F2A967B32F7" modified="2016-04-13" version="1">MSIHVSSFTHHLSDPTRFFGLRIWMTVVICVVLLIVTLFFVSLCSSSCRRRRRRRKNSDKNYCLGSRRMMDRRLLPQKEPEHHAVYSDQSHCSRSKFHLVDMPPAVIGGAGRCKQYSANEIQLATDGFSHGNMIGSVEHRVVYRGDERVAVHVLINTSRTIKEFMEDVEAIWGIRHNNLVKLIGSSIDRSKSTLIYEYVDNGNLHQWLHQCAARTSPLTWDIRMGIILGITKGLAYLHEDSEPKVVHQRLKSSSILLDHQWNPKISDIGITKLLGLEQNLFVSRNVIGMSGYLDPEYVSTHNFSEKSDVYSYGVLVMEIISGRTPEYLVDWLKLMVSNQRFDDIVDDRLQEPPSIKELKRIILIALRCVDPVIENRPTMGEVIHMLEPRDLLLDDVLFSDSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHX6</accession>
    <name>A0A124SHX6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000981">
        <property type="protein sequence ID" value="KVI10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHX6"/>
    <dbReference type="Gramene" id="KVI10907">
        <property type="protein sequence ID" value="KVI10907"/>
        <property type="gene ID" value="Ccrd_010687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="91" mass="10325" checksum="549FE0D0EFE67377" modified="2016-04-13" version="1">MDEDMVSVDPFEFHSEEEPYQNHEDKRPLKVVTDGMTSSTISQGDPRIVSQDRLSSNSKFRSNAFRLVSTCPLRIFEFLLSLINVASSIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103DZ83</accession>
    <name>A0A103DZ83_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011032">
        <property type="protein sequence ID" value="KVE25412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103DZ83"/>
    <dbReference type="STRING" id="59895.A0A103DZ83"/>
    <dbReference type="Gramene" id="KVE25412">
        <property type="protein sequence ID" value="KVE25412"/>
        <property type="gene ID" value="Ccrd_024026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF65">
        <property type="entry name" value="HISTONE DEACETYLASE INTERACTING DOMAIN, SIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVE25412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="144" mass="16977" checksum="275146AE2532D330" modified="2016-04-13" version="1">MFIAFQEVRNSHEGPSLRCIQILYGGYGLNVIKELRMNVPLSLPIILNHLKQKQEEWRMFSSGFNKLWKPVFTANHHMSLDHHNAYLHQDSKFLCTNDSLAEINGIGDRRSEDTKLEFMFSNMNIHKLRLLSTHKTILFRYLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103STS7</accession>
    <name>A0A103STS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007364">
        <property type="protein sequence ID" value="KVG94664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103STS7"/>
    <dbReference type="STRING" id="59895.A0A103STS7"/>
    <dbReference type="Gramene" id="KVG94664">
        <property type="protein sequence ID" value="KVG94664"/>
        <property type="gene ID" value="Ccrd_026071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000006">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF220">
        <property type="entry name" value="ANNEXIN D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0041">Annexin</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVG94664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="28662" checksum="1F62B7A97F098B23" modified="2016-04-13" version="1" fragment="single">CDAACWVGYLLVYRYLEFATDHRPKQLKEEEEEQQWRHLRYHLPFLLPLRTVSNSKKLLQRAVMLWTLEPTERDAYLVNEATKKLTASNWVLMEIACSRSSDHLFCVRKAYHAKNKKSIEEDVAHHTSGDFRKLLVPLVSAFRYEGDEDLKADPKDEYLKLLRSTIKCLTVPEKYYEKVLRLAINKLGTDEWALTRVITTRAEVDLKRIAEEYQRRNSVPLDKAIAGDTSGDYEQMLLALMGHDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB29</accession>
    <name>A0A103XB29_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Concanavalin A-like lectin/glucanase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_025325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006225">
        <property type="protein sequence ID" value="KVH87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB29"/>
    <dbReference type="STRING" id="59895.A0A103XB29"/>
    <dbReference type="Gramene" id="KVH87436">
        <property type="protein sequence ID" value="KVH87436"/>
        <property type="gene ID" value="Ccrd_025325"/>
    </dbReference>
    <dbReference type="OMA" id="AGFEGHD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000002">
        <property type="entry name" value="Beta-fructofuranosidase, insoluble isoenzyme CWINV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118648" evidence="5">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="364"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="65455" checksum="B86DA391892E9525" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBQ7</accession>
    <name>A0A103XBQ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_024928</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005840">
        <property type="protein sequence ID" value="KVH87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XBQ7"/>
    <dbReference type="OMA" id="ACAQWFH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000002">
        <property type="entry name" value="ABC transporter C family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000508">
        <property type="entry name" value="ABC transporter C family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF165">
        <property type="entry name" value="ABC TRANSPORTER C FAMILY MEMBER 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="298"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="613"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="892"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1315" mass="147708" checksum="F5AFC024CE140A77" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCS9</accession>
    <name>A0A103XCS9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Microtubule-associated protein, MAP65/Ase1/PRC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005434">
        <property type="protein sequence ID" value="KVH88366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCS9"/>
    <dbReference type="STRING" id="59895.A0A103XCS9"/>
    <dbReference type="Gramene" id="KVH88366">
        <property type="protein sequence ID" value="KVH88366"/>
        <property type="gene ID" value="Ccrd_024003"/>
    </dbReference>
    <dbReference type="OMA" id="GMDFANT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF0">
        <property type="entry name" value="65-KDA MICROTUBULE-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH88366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60636" checksum="74DE9CCDB54D2B63" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCW7</accession>
    <name>A0A103XCW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_026831</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005410">
        <property type="protein sequence ID" value="KVH88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCW7"/>
    <dbReference type="Gramene" id="KVH88425">
        <property type="protein sequence ID" value="KVH88425"/>
        <property type="gene ID" value="Ccrd_026831"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF1">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="336" mass="37444" checksum="F49B1CAAE1B1C438" modified="2016-04-13" version="1" fragment="single">MADNVQPGIAIVANRDEDDFDDFEMNQATFQPAEPVLPFHQQMTQHISMVVYCIRCGHGYHVECLEAWLKEHPNCPLCRTPVSGSHDQDNTTHNHNLYLKKFYDMVSRYGTSALETMVDWLTSHMRHPLASSVHNESGFIVENLLHYEDDFDDFEMNQATFQPAEPVLLFPPADDSTHFDEAWLKEHPICPLCRTPVYGSHDQDNTTHNHNVYLKKFYDMVSHSKEEEDALQLPIPNGKQEAKKEEKPVVPNKKDLAPKVPVCVKDYVYTAGEENKEEEKKKSGANLISERQGRRRAGTAATSGGGAATSGGGGSDGDDGVREGEGDGRGGSDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCY4</accession>
    <name>A0A103XCY4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005392">
        <property type="protein sequence ID" value="KVH88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCY4"/>
    <dbReference type="Gramene" id="KVH88493">
        <property type="protein sequence ID" value="KVH88493"/>
        <property type="gene ID" value="Ccrd_026694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF307">
        <property type="entry name" value="TIR DOMAIN, P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="725"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="904" mass="102409" checksum="E1E08E1E8F92452A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDC3</accession>
    <name>A0A103XDC3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromo adjacent homology (BAH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_026148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005352">
        <property type="protein sequence ID" value="KVH88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDC3"/>
    <dbReference type="STRING" id="59895.A0A103XDC3"/>
    <dbReference type="Gramene" id="KVH88665">
        <property type="protein sequence ID" value="KVH88665"/>
        <property type="gene ID" value="Ccrd_026148"/>
    </dbReference>
    <dbReference type="OMA" id="MMYVVPD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917:SF3">
        <property type="entry name" value="BROMO ADJACENT-LIKE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="496" mass="55125" checksum="2084DACBF40A0CB3" modified="2016-04-13" version="1" fragment="single">MPRSTNLQNQSPDQMIEVPTELEGENSDIIWSGGASSCCKKLKHYPAFCRSGTTIPDYRNQKMVKVRWFHRTDEVSGLISEPRPHEIIITPHFQVVSAECVDGLATVLTPKHYEHCLAVLSEDFSDGIYMCSRQIKKNKITPFPLSKLRGYSSQTIFSVLDLSIGPNKLKPQITSREEKKEVEQPTDPKMKIKLSSKGLDGQSSRGVLKITNSVSDNQVEKTQPTDPKMKIKLSSGGLDGQSPIGVLKIYNSISDNKVEKTQPTDPKSKIKLSSKGLDGTSEPHHEIPSFSVGEEIEVSEKVLKVLYMDVEDVEGSGNLEEWVLAYRLAVPDKLGMRCLGRHTIRPFPAKNSSNGSFSIGAPVDAWWCDGWWEGVVVATNIRGKNPFHVYFPGENKFQNFENEKLRTSKDWVDNIWVELNPKPDVLNFISSNVKSNMKLQRCITLGGSSGSGNGLSSVDHKVVASIETEAAEKKGKELPALKKLKGVVLKKKKAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDH1</accession>
    <name>A0A103XDH1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005342">
        <property type="protein sequence ID" value="KVH88748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDH1"/>
    <dbReference type="STRING" id="59895.A0A103XDH1"/>
    <dbReference type="Gramene" id="KVH88748">
        <property type="protein sequence ID" value="KVH88748"/>
        <property type="gene ID" value="Ccrd_025861"/>
    </dbReference>
    <dbReference type="OMA" id="KYKIMHS"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="36421" checksum="ABA53C0825FA5264" modified="2016-04-13" version="1">MAKYGELWDDSALVKAFDDAISKYKIMHGKGGDEDLLKEEKITKGTEENAPIIMNGSNEVKSANVETDNKTTDMTKNITHTREATDSSVAEKCSSEVIDKCTPPSIVVQVDAESAEAYKRLLDQYNAVEEQRQKLLEQFSQYGNWDYQGYGYGYDYGAAYDSQYHPVPAPQPSGPPICSCRPYVCPYSTAPCTSLAAASSCETCVGSTALAHSGSPAPLEDGGFIKAAMRAVDQAIHSFNTQTSGIPEVDKEGKKGQEVETGSTNVAQDRTSQTDLSVVLNAWFSAGFHTGKYLSEQRKPAVSTSSPLTTREEIERVPSKENSTDSSFKEIPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFD2</accession>
    <name>A0A103XFD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSL (TC 2.A.67.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005190">
        <property type="protein sequence ID" value="KVH89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFD2"/>
    <dbReference type="STRING" id="59895.A0A103XFD2"/>
    <dbReference type="Gramene" id="KVH89642">
        <property type="protein sequence ID" value="KVH89642"/>
        <property type="gene ID" value="Ccrd_008363"/>
    </dbReference>
    <dbReference type="OMA" id="TTHMSIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051980">
        <property type="term" value="F:iron-nicotianamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF11">
        <property type="entry name" value="METAL-NICOTIANAMINE TRANSPORTER YSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16987" checksum="A4E601E86A69A24B" modified="2016-04-13" version="1" fragment="single">MATTILINGFHSEGDVMAKYVRNIFHKPFCNVVLYTTHMSICRKQIKGFAKFRLVSCGQSFSGFSYGKGECGFAQFPTFRLEAYDNIFYFDFSMTYVGTGMICLHISFSLLFGVVMSWGIMGPLIEKQKREWFPSNVPESSTKNLNGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFX1</accession>
    <name>A0A103XFX1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF632 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005121">
        <property type="protein sequence ID" value="KVH89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFX1"/>
    <dbReference type="STRING" id="59895.A0A103XFX1"/>
    <dbReference type="Gramene" id="KVH89963">
        <property type="protein sequence ID" value="KVH89963"/>
        <property type="gene ID" value="Ccrd_008044"/>
    </dbReference>
    <dbReference type="OMA" id="FFMVDNM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF7">
        <property type="entry name" value="DNA LIGASE (DUF630 AND DUF632)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="324"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="406"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84208" checksum="B8C18F96B124C421" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGH4</accession>
    <name>A0A103XGH4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein TIFY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Jasmonate ZIM domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Repressor of jasmonate responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The jas domain is required for interaction with COI1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TIFY/JAZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005106">
        <property type="protein sequence ID" value="KVH90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGH4"/>
    <dbReference type="STRING" id="59895.A0A103XGH4"/>
    <dbReference type="Gramene" id="KVH90328">
        <property type="protein sequence ID" value="KVH90328"/>
        <property type="gene ID" value="Ccrd_007664"/>
    </dbReference>
    <dbReference type="OMA" id="KAGFTHG"/>
    <dbReference type="OrthoDB" id="1908882at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040390">
        <property type="entry name" value="TIFY/JAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077">
        <property type="entry name" value="PROTEIN TIFY 4A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077:SF8">
        <property type="entry name" value="PROTEIN TIFY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00979">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1184">Jasmonic acid signaling pathway</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118766" description="Protein TIFY" evidence="4">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Tify" evidence="5">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="403" mass="42221" checksum="3DACF0312DC48DA1" modified="2016-04-13" version="1">MAAAVLLLNIMAQNNTTNATDDVKPTILHDFLGRGCAPATKFAADASSPSASVSGGGARGGGPVSTTSDLGSERQVGTHFEGVPFFGQKGDFSGSKIRYSGNKRSNSDSVFMAPSRDGIPQLRPDFPETSHLMKMLRNVGAERPRWPHEDESFMGVHQMRPTASSLMVQPATGSKTDANASKWERAIPVNVGPVLQYPPRVGQVVSYGYQAVSNRFKDANVGSSVISQSAADEGSRTGIKGSGILSSVNVMAEPSSSKQKSLNSNTEPGSSAPLQRQGSTSASRQMTIFYGGQAHVFDDVHPNKADVIMALAGSNGGSWSTSFSPNSAVKPSGGEAIPVSGENDTIMAAKTALSSKDNLGRLYSPGNSSHGLGSSDRMLMLSGGQSMKDARGAMQDQKTEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGM3</accession>
    <name>A0A103XGM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005103">
        <property type="protein sequence ID" value="KVH90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGM3"/>
    <dbReference type="STRING" id="59895.A0A103XGM3"/>
    <dbReference type="Gramene" id="KVH90418">
        <property type="protein sequence ID" value="KVH90418"/>
        <property type="gene ID" value="Ccrd_007566"/>
    </dbReference>
    <dbReference type="OMA" id="RVKKFDM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051861">
        <property type="entry name" value="NET_actin-binding_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258:SF26">
        <property type="entry name" value="KINASE INTERACTING (KIP1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07765">
        <property type="entry name" value="KIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51774">
        <property type="entry name" value="NAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="5">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="393" mass="44237" checksum="F7DAC17FC7F9EC79" modified="2016-04-13" version="1" fragment="single">ACTHHLRSSTTDDRPPNLSSDLLVVSVHCGSKLHSLPNKVLIGPADMMLPVTYSGCNALDGMSSSSSAEQSRRSKSKFITKPSWLLLSISDLEDKIQAINGEEKPDTFGERADFYYRKRPELLALLQELYNRYLYLADRYTRTLSKQQLRHHEVICPPVDDNNNTNADYSDDAESSLSYQPPADTQKPIASELVISELVMRFVEYEIEESKKKIELQKSLLEVLESERVVLTNENSRLASESLFMKRKAGELARCVLLERSEDQRVFVLSRKIDDLQGQIYELEKRNKEYYDKLKKQHESSEGKSGKKNIKRLMVKSNGGGGSSSSISWSGGEDETGCSMSSTSNSSSTCTSLAQVMKEKKHPGGSGKKVYGWWDRVKKFDMFMCGPHLDATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGV1</accession>
    <name>A0A103XGV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Syntaxin/epimorphin, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGV1"/>
    <dbReference type="STRING" id="59895.A0A103XGV1"/>
    <dbReference type="Gramene" id="KVH90523">
        <property type="protein sequence ID" value="KVH90523"/>
        <property type="gene ID" value="Ccrd_007435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000008">
        <property type="entry name" value="Syntaxin 132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="31382" checksum="C4B13EDC957EFDF0" modified="2016-04-13" version="1">MNDLLSASFGSPRRSGHGGGDIEMGIQHASQSGELELDDHFKMVQHIEKEFDVLNKLLKKLQDAHEESRSVTKAAAMKAIKQRMENDVDEVGRVARFIKAKIEELDKENLINRQKPGCGQGTGVDRSRTATTLALKKKFKDRVKEFQHVYQTLRESIHQEHREVIERRVFTVTGTRADEEVVDTLAEIHERHSAAIEVERKLLELQQIFSDLAILVDSQGEMLDNIETHVSSAVDHVQSGNRALQNAKKLKKNSRKWMCLAIIILEILPGKFRQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHN9</accession>
    <name>A0A103XHN9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHN9"/>
    <dbReference type="STRING" id="59895.A0A103XHN9"/>
    <dbReference type="Gramene" id="KVH90854">
        <property type="protein sequence ID" value="KVH90854"/>
        <property type="gene ID" value="Ccrd_007117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118799" evidence="2">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="15426" checksum="01AD287E3F1075E3" modified="2016-04-13" version="1">MNSNKWLKIWIEIGVVLSGVDLFEAQLSSCAYQVLFFGVDQNGLTLHEWDPDANYDYFDTLASIDFIYNLGILLGVFASFVCPIRKFLTLKQPYRVPFWIPLLVVMCLLMSAFFGANNDDCKKDCIFCYKDCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI89</accession>
    <name>A0A103XI89_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPX, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005068">
        <property type="protein sequence ID" value="KVH91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI89"/>
    <dbReference type="STRING" id="59895.A0A103XI89"/>
    <dbReference type="Gramene" id="KVH91219">
        <property type="protein sequence ID" value="KVH91219"/>
        <property type="gene ID" value="Ccrd_006772"/>
    </dbReference>
    <dbReference type="OMA" id="CIKLADP"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14481">
        <property type="entry name" value="SPX_AtSPX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031142">
        <property type="entry name" value="SPX_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978:SF2">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="243" mass="28163" checksum="691C045CE0287567" modified="2016-04-13" version="1">MKFGKRLKQHVQETLPGWRDMYLNYKDLKKLVKLISGYGKSKAAFVYLLDNEIDKFNLFFMEQEEDFVIRHKELQQRIKKVKEGEASSEGEYEEEMSRIRKDIVDFHGEMVLLVNYSNINYTGMAKILKKYDKRTGGLLRLPFIQKVLEQPFFTTELISKLVKECEATIDELFPTVVVAEEMKESTITMAGEGIFRNTVAALMTMKEIRKGSSTQSHFSLPALNLPDTELIRSFQFNAPIPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIA8</accession>
    <name>A0A103XIA8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_006726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Possesses 5'-&gt;3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01005065">
        <property type="protein sequence ID" value="KVH91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XIA8"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF62">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="10">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH91258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="941" mass="107516" checksum="D14C9B2DFC71FC11" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIH0</accession>
    <name>A0A103XIH0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005042">
        <property type="protein sequence ID" value="KVH91370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIH0"/>
    <dbReference type="Gramene" id="KVH91370">
        <property type="protein sequence ID" value="KVH91370"/>
        <property type="gene ID" value="Ccrd_006605"/>
    </dbReference>
    <dbReference type="OMA" id="MTLWNDL"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="344" mass="39459" checksum="B8BFE1D7D856D090" modified="2016-04-13" version="1">MSAPTASNASSISIVKPSAEEIERRRAKLSLLFDRYKDKFTTLPKENGWIVENLYMYQGFWLMSQSLYSLETVMAAQDTFQAHPNDIYLVTLPKSGTTWIKALVFAIMNRNRYKNKSLSTHPLLISNPHHCVPFVEDESLRTEPSYLDAHSARLFATHIPYTLLPQSILDSGCRLVYMCRNPKDLLVSLFHFVNKVRGKSRGLMTIEELFHMFSKGVSPYGPYWDHVKAYYNISLEHPTRILFLTYESMKLDTVNNVKRLAEFLGFPFTEEENAKGVVEEIVSLCSFENLSEVNKHGNFLVGVPNNIFFREGKVGNWSNHLTSEMSQTLDQITNEKFNGLDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ00</accession>
    <name>A0A103XJ00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004977">
        <property type="protein sequence ID" value="KVH91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ00"/>
    <dbReference type="Gramene" id="KVH91454">
        <property type="protein sequence ID" value="KVH91454"/>
        <property type="gene ID" value="Ccrd_006522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="61" mass="6938" checksum="92CF48F5C5EDFAA8" modified="2016-04-13" version="1" fragment="single">FGNDPDAKRFRAHKPASVVSLPSSSFSSDLSSTPPYYSVGLTRKSNMRRCDVHQKVWRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKU3</accession>
    <name>A0A103XKU3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PC-Esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_005362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004812">
        <property type="protein sequence ID" value="KVH92596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XKU3"/>
    <dbReference type="Gramene" id="KVH92596">
        <property type="protein sequence ID" value="KVH92596"/>
        <property type="gene ID" value="Ccrd_005362"/>
    </dbReference>
    <dbReference type="OMA" id="WSKACIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF319">
        <property type="entry name" value="PMR5 DOMAIN, PC-ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="138"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="577"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="756"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="97397" checksum="C2021E6E9646108D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLF4</accession>
    <name>A0A103XLF4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLF4"/>
    <dbReference type="STRING" id="59895.A0A103XLF4"/>
    <dbReference type="Gramene" id="KVH92805">
        <property type="protein sequence ID" value="KVH92805"/>
        <property type="gene ID" value="Ccrd_005172"/>
    </dbReference>
    <dbReference type="OMA" id="WVVTPYM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000099">
        <property type="entry name" value="Serine/threonine-protein kinase BLUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000208">
        <property type="entry name" value="serine/threonine-protein kinase BLUS1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF9">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="635" mass="71271" checksum="01F867A760B79E34" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNF2</accession>
    <name>A0A103XNF2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Berberine/berberine-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_003953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNF2"/>
    <dbReference type="STRING" id="59895.A0A103XNF2"/>
    <dbReference type="Gramene" id="KVH93994">
        <property type="protein sequence ID" value="KVH93994"/>
        <property type="gene ID" value="Ccrd_003953"/>
    </dbReference>
    <dbReference type="OMA" id="HDLWWAH"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118951" evidence="8">
        <location>
            <begin position="24"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="562" mass="62946" checksum="EC986E12A4A23CD8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNN1</accession>
    <name>A0A103XNN1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01004578">
        <property type="protein sequence ID" value="KVH93995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNN1"/>
    <dbReference type="STRING" id="59895.A0A103XNN1"/>
    <dbReference type="Gramene" id="KVH93995">
        <property type="protein sequence ID" value="KVH93995"/>
        <property type="gene ID" value="Ccrd_003952"/>
    </dbReference>
    <dbReference type="OMA" id="QMTLTEP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000265">
        <property type="entry name" value="Mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="70"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="330" mass="36685" checksum="028965E63E0975D6" modified="2016-04-13" version="1">MKKGNLAPFLKLNLPPSDETSLAKFLTKSGTFMDGDLLVNRDGVRIVSQSQSDTPPLIQASDNQLSLADFDAVKVVGKGNGGVVRLVQHKWTGQFFALKVIQMNVEESARKQIAQELKINQSSQCPNVVVCYQSFYDNGAVSIILEYMDGGSLADFLKTVRFIPEPYLAAICKQVLRGLWYLHHEKHIIHRDLKPSNLLINHRGEVKITDFGPERILAGNHGYKSDIWSLGLVLLECATGQFPYSPPQPGGWVNVYELMETIVGQQPPRPPSDQFSPQFCSFIDACLQKEPKDRSSANELMSHPFINMFDDLAIDLASYFTEAGSPLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQT9</accession>
    <name>A0A103XQT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pectinesterase</fullName>
            <ecNumber evidence="4 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_002844</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01004399">
        <property type="protein sequence ID" value="KVH95129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQT9"/>
    <dbReference type="STRING" id="59895.A0A103XQT9"/>
    <dbReference type="Gramene" id="KVH95129">
        <property type="protein sequence ID" value="KVH95129"/>
        <property type="gene ID" value="Ccrd_002844"/>
    </dbReference>
    <dbReference type="OMA" id="HGCHITG"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="15">
        <location>
            <begin position="45"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH95129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="62003" checksum="85575A8411A6F354" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRE2</accession>
    <name>A0A103XRE2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004385">
        <property type="protein sequence ID" value="KVH95511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRE2"/>
    <dbReference type="STRING" id="59895.A0A103XRE2"/>
    <dbReference type="Gramene" id="KVH95511">
        <property type="protein sequence ID" value="KVH95511"/>
        <property type="gene ID" value="Ccrd_002415"/>
    </dbReference>
    <dbReference type="OMA" id="NTCDITP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01958">
        <property type="entry name" value="HPS_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000003">
        <property type="entry name" value="pEARLI1-like lipid transfer protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027923">
        <property type="entry name" value="Hydrophob_seed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051636">
        <property type="entry name" value="Plant_LTP/defense-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14547">
        <property type="entry name" value="Hydrophob_seed"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119029" evidence="2">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH95511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="252" mass="26674" checksum="5D85EDB01F3C499D" modified="2016-04-13" version="1">MGSRALATTAFLITLNLLFFTLVSSTQCPPPPKSPKHHHHHKATTCPKDTLKLGVCANLLNDLVHLVVGTPPKTPCCSLLGDLVDLEAAVCLCTAIKANVLGINLNVPVSLSLLLNYCGKKPLEMGSRALATTAFLITLNLLFFTLVSSTQCPPPPKSPKHHHHKASTCPKDTLKLGVCANLLNDLVHLVVGTPPKTPCCSLLGDLVDLEAAVCLCTAIKANVLGINLNVPVSLSLLLNYCGKKVPKGFQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSF5</accession>
    <name>A0A103XSF5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004362">
        <property type="protein sequence ID" value="KVH96053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSF5"/>
    <dbReference type="STRING" id="59895.A0A103XSF5"/>
    <dbReference type="Gramene" id="KVH96053">
        <property type="protein sequence ID" value="KVH96053"/>
        <property type="gene ID" value="Ccrd_001850"/>
    </dbReference>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="587" mass="66212" checksum="C87507212963300D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSN1</accession>
    <name>A0A103XSN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase, five-bladed beta-propellor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004353">
        <property type="protein sequence ID" value="KVH96156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSN1"/>
    <dbReference type="STRING" id="59895.A0A103XSN1"/>
    <dbReference type="Gramene" id="KVH96156">
        <property type="protein sequence ID" value="KVH96156"/>
        <property type="gene ID" value="Ccrd_001757"/>
    </dbReference>
    <dbReference type="OMA" id="DWDSLFI"/>
    <dbReference type="OrthoDB" id="3510at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35279">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35279:SF1">
        <property type="entry name" value="ARABINANASE_LEVANSUCRASE_INVERTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="468" mass="51651" checksum="CB1E7413D48A7AB5" modified="2016-04-13" version="1">MEITATINTTLLFPTTPRSRNPSIIPSKRPNLFDLYPAFSNPKNPHKNPICLTHCSTKPTISDDKDNVIKDQDSTISSDSNFNIQNPQKPSSNQEKSPPNSSISRGLVLDLGSEGSWDSIEIGSPVVKRFLSDEEERWYMWYHGRSGGNLDPGSVGLAVSSNGIHWERGKGAVQSGSNVGLVLKSSSDWWSFDTNGVMPGEVVIMSSSKIRASNAVYWLYYTGFSNEKIELLDNSLEFSLENPENGGKGKVCRSLIGLAMSQDGRHWARIEGEHHSGSLFDLGSEGEWDSMFIASPQVVFHASGDLRMYYHSLDLEKGHFGIGMARSRDGIRWVKLGKIMGGGRIGNFDECGVINPCVVRNKKDGGYLMVYEGVGVDGERFIGLALSSDGLKDWRRVEDGPILKRAEENGCWDDGGVGSPCLVHMDGEDDEWRLYYTGIGRDGHTGIGMAVSEGKDVKNFRRWTGFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XST7</accession>
    <name>A0A103XST7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-D1-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004345">
        <property type="protein sequence ID" value="KVH96229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XST7"/>
    <dbReference type="STRING" id="59895.A0A103XST7"/>
    <dbReference type="Gramene" id="KVH96229">
        <property type="protein sequence ID" value="KVH96229"/>
        <property type="gene ID" value="Ccrd_001680"/>
    </dbReference>
    <dbReference type="OMA" id="QATTVGM"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39423" checksum="1C9853497753CC2F" modified="2016-04-13" version="1">MGKQEKERLNQILIHHLNSIHETFQVLDQSPPSSLEKVSWDDVVKMGQQLYKQATTVGMLWSGEGPDAKSLEESMGAYSNLLQGFLLLSHGSMIGAGTTLSSCIHASVKQVIDCSFMLLKESVASYGNSSKAHKLSIPQIVGTVWEACSALKKTPGTNITAIGRAMTQIAVSVKDVHREMKELKPASSDPSVEISDKVPKPENDTHDSDNSSDEELGSDLSPEEMKVTELAIDVVSETLSTIKEIIRSITGLLKNAQTPTESNQMVDSLERLLTSCRNMGLQIDEIGACLYPPQEVSAIKTASEKMMSFVGEMQVELENIKGSSDAFVHASNGLMSSLRQLESGLGCSSDDELASEMKNLDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT85</accession>
    <name>A0A103XT85_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004304">
        <property type="protein sequence ID" value="KVH96454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT85"/>
    <dbReference type="STRING" id="59895.A0A103XT85"/>
    <dbReference type="Gramene" id="KVH96454">
        <property type="protein sequence ID" value="KVH96454"/>
        <property type="gene ID" value="Ccrd_001456"/>
    </dbReference>
    <dbReference type="OMA" id="GYVKHRI"/>
    <dbReference type="OrthoDB" id="1858506at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17182" checksum="9096257A250F4F6C" modified="2016-04-13" version="1">MTSVSIQIEVSSTFPADKVFKVFSDFDNVAPKVNPAVFKSIETVEGNGGVGTIKIFTFGDAVPFTSGKYKVDAIDTSNFSYNYSFFEGDCLMGILDSINHHIKVVPTDGGSIFKQTVIYNCKGSDKPSEDILKAEKEIYEKTYKAIEAHGAAHPDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTQ6</accession>
    <name>A0A103XTQ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004226">
        <property type="protein sequence ID" value="KVH96740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTQ6"/>
    <dbReference type="STRING" id="59895.A0A103XTQ6"/>
    <dbReference type="Gramene" id="KVH96740">
        <property type="protein sequence ID" value="KVH96740"/>
        <property type="gene ID" value="Ccrd_001168"/>
    </dbReference>
    <dbReference type="OMA" id="TINGRWR"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017088">
        <property type="entry name" value="Wax_synthase_Magnoliopsida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF77">
        <property type="entry name" value="ACYL-COA--STEROL O-ACYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037006">
        <property type="entry name" value="Wax_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="10">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="40511" checksum="FC1E6B35709C11D4" modified="2016-04-13" version="1">MELKDEMNNLIKVSFYAYISLLYCFFVGKIIPKGVPRLLTILPVVIFFLSIPLFLTSVHSIGAISFYISWLANFKLLLFAFEKGPLSSPSIPLFRFFAMACFPIDVSQTSKGFSKPKNFSTKSVISYGTKGLLLAFLLRVYHNHHEVMNPMVAWCFFGFSVYLMLELLVAISSAIIGLFLRVELDPQFDKPYLATSLQDFWGRRWNVMVNRILHPTVYDPMLKLSVRVVGRLWAPVPAILTTFAVSGLMHELIFFYFTRAWPTGEVMLFFCLHGVCLVMEVVIKKALRVKRNLPRQLTAPLVVSFVLATSYWLFLPELLRCNMVERAFEEYGMVSELAMDVVRTPPVFLKFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTZ5</accession>
    <name>A0A103XTZ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004128">
        <property type="protein sequence ID" value="KVH96878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTZ5"/>
    <dbReference type="STRING" id="59895.A0A103XTZ5"/>
    <dbReference type="Gramene" id="KVH96878">
        <property type="protein sequence ID" value="KVH96878"/>
        <property type="gene ID" value="Ccrd_001031"/>
    </dbReference>
    <dbReference type="OMA" id="FINVTHI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF9">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119119" evidence="8">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH96878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="273" mass="30295" checksum="C42984E967559630" modified="2016-04-13" version="1" fragment="single">MAYCQLNLLFSIRIFIAVMQFEIFIVNGEPQVPCYFIFGDSLVDSGNNNKLVTRAKANYPPYGIDFPQGVTGRFTNGRTIADIIVNIGSNDYINNYLMPTIYTTSHKHTPYEYATLLTRQYARQLKTLYDLGGRKIVVFGLGPVGCTPAEISIFGTDGSPCVESINDAVRQFNDKLKPLIHELNHENPDARFTFINLTSISSLQEGIRLSNVPCCKVRVDGQCAQNALVCPDRAMSVYYDGFHPTEVATVLIASTSYTALSPMDASPYDISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU65</accession>
    <name>A0A103XU65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004082">
        <property type="protein sequence ID" value="KVH96916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU65"/>
    <dbReference type="Gramene" id="KVH96916">
        <property type="protein sequence ID" value="KVH96916"/>
        <property type="gene ID" value="Ccrd_000991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36615">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36615:SF7">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="73" mass="8077" checksum="CF116F60AF23E125" modified="2016-04-13" version="1">MVGVRGSRTIKNDRSAGHGRPVPRRGQVKVGIVLGLAHSVASLFSFNNARFQSGSQPWIWLSIPFSPSFRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWB2</accession>
    <name>A0A103XWB2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWB2"/>
    <dbReference type="STRING" id="59895.A0A103XWB2"/>
    <dbReference type="Gramene" id="KVH98087">
        <property type="protein sequence ID" value="KVH98087"/>
        <property type="gene ID" value="Ccrd_023694"/>
    </dbReference>
    <dbReference type="OMA" id="SSHNENC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF24">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="64159" checksum="9E1E5C65075ACC3E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWF2</accession>
    <name>A0A103XWF2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003809">
        <property type="protein sequence ID" value="KVH98136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWF2"/>
    <dbReference type="STRING" id="59895.A0A103XWF2"/>
    <dbReference type="Gramene" id="KVH98136">
        <property type="protein sequence ID" value="KVH98136"/>
        <property type="gene ID" value="Ccrd_023633"/>
    </dbReference>
    <dbReference type="OMA" id="DIVAGCD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05506">
        <property type="entry name" value="Bromo_plant1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037377">
        <property type="entry name" value="GTE_bromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF33">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="10">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="759"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="803" mass="89095" checksum="8E6AA293F341DA42" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWG6</accession>
    <name>A0A103XWG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWG6"/>
    <dbReference type="STRING" id="59895.A0A103XWG6"/>
    <dbReference type="Gramene" id="KVH98183">
        <property type="protein sequence ID" value="KVH98183"/>
        <property type="gene ID" value="Ccrd_023603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase OSR1/WNK CCT" evidence="10">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="52150" checksum="3394150A96CE933B" modified="2016-04-13" version="1">MPLESSSDHEVEDSDSEFVEVDPSGRYGRFLLFLIEISRYRAFDELEGIEVAWNQIKVYDFLRNPEELERLYSEVHLLKTLKHKNIIKFYNSWVDAKNDHINFITEIFTSGTLRQYGVKPASLKKVKDPEVRSFIEKCIAKVSDRLSAKELLMDQTTNDTMPDTARDFTLKGQMRDPNTVFLKLRIEDTTGHVRNIHFPFDIKFDTQTAVAREMVEELDLTDQDVSTIAEMIEAEIRSCFPDWALNVNSNEHEANEVPDSTEDSAFDSRYESPSPSTNKSTGASPGFLSLERLPSGRRYWSDEPKNGCSPLQPIPSDVSEDENADPEALSSDDHGSGDDAPTENMEEILHHHHDNDNDDNDDDDDDDDDDDDDDDDDDDDDTRPKETSDVSMIVEKLEHIMVEQQKELDELSKQHRLILSDILMKLPPETRQEVVTSCKVEISKAGISKDSNHPLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXQ5</accession>
    <name>A0A103XXQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, Dof-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_022933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003647">
        <property type="protein sequence ID" value="KVH98855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXQ5"/>
    <dbReference type="STRING" id="59895.A0A103XXQ5"/>
    <dbReference type="Gramene" id="KVH98855">
        <property type="protein sequence ID" value="KVH98855"/>
        <property type="gene ID" value="Ccrd_022933"/>
    </dbReference>
    <dbReference type="OMA" id="PPATFWN"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089">
        <property type="entry name" value="CYCLIC DOF FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089:SF1">
        <property type="entry name" value="CYCLIC DOF FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="335" mass="37600" checksum="B0D8325A62372B37" modified="2016-04-13" version="1">MEDPGIKLFGKKIVLPEINKSINLPVMFTAGGADKDGGYDHTRGLLKDSLEGKRVNREGVEKDHMVESENPKTPSIEEETRTQKSESNPQTKTLKKPDKILACPRCTSMDTKFCYYNNYNVNQPRHFCKSCQRYWTAGGAMRNMPVGAGRRKNKNPASHCRFITIPQETHCVSGGSTVTTSDSTPENFQDQNRFHSHVHSIPGVSWSYNPWNSRIPIPAICPPMPIYPSTNWNCIPFLPPCDPILGKHSLDSDDCDQDLKKPKNSVLIPKTLRIDDPDEAAKSSIWATLGIKNENFKAFEEKGEERKKRPATITSPVLYANPAAFSRSLCFQEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXS3</accession>
    <name>A0A103XXS3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CheY-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_022877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003642">
        <property type="protein sequence ID" value="KVH98898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXS3"/>
    <dbReference type="Gramene" id="KVH98898">
        <property type="protein sequence ID" value="KVH98898"/>
        <property type="gene ID" value="Ccrd_022877"/>
    </dbReference>
    <dbReference type="OMA" id="FDMINDC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF62">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="19370" checksum="1EFAB2C398295E1F" modified="2016-04-13" version="1">MRQILQIFLLQFDMINDCKDLHVLAVDDSNIDRKVIQRLLQISSFKVTVVESGSRALQYLGLDEDKNSDRFDNSSTLREIPVVIMSSENSLTRIDRCLEEGAEDYLLKPVKLSDVTRLKNSILKSGSGEITGIQTNKRKHKRDQSPLPTSIDCHTPPPASPQHSLEKRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXU3</accession>
    <name>A0A103XXU3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KNOX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXU3"/>
    <dbReference type="STRING" id="59895.A0A103XXU3"/>
    <dbReference type="Gramene" id="KVH98930">
        <property type="protein sequence ID" value="KVH98930"/>
        <property type="gene ID" value="Ccrd_022836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005541">
        <property type="entry name" value="KNOX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48452">
        <property type="entry name" value="FUSED COMPOUND LEAF 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48452:SF1">
        <property type="entry name" value="FUSED COMPOUND LEAF 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03791">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01256">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNOX2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="17531" checksum="18F9FBB3E245AB7E" modified="2016-04-13" version="1">MMEEMYGLMNYHEQVPPPDSARENYGHHAFDDQSPEVGAPPDISNLFDEIFRDNDFCRRSSACSCLGDDPELDEFMETYCEMLGKYRSDLARPFDEATTFLNNMQTQLTNLCKGTSITYHTVLIGNEALAGYFYAASFWIRQLQQTRRGIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XY32</accession>
    <name>A0A103XY32_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XY32"/>
    <dbReference type="Gramene" id="KVH98959">
        <property type="protein sequence ID" value="KVH98959"/>
        <property type="gene ID" value="Ccrd_022857"/>
    </dbReference>
    <dbReference type="OMA" id="EMGACDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47580">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47580:SF1">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="33246" checksum="E3F8A8D6FB1D9CF5" modified="2016-04-13" version="1">MLVTPSASNKTPPPYPTTAVASSINHPENPQIHLKSIDRRYILASLAASITPFFAPQPPVSYDESPPLLPISVLPSAAARGLFQMPPVRLSNRYYLVRAGESEFESLGIINTNPVAKTSVDNGLSNIGKKQTVRAALRLKEMGACENSCWIWPSITQRSYQAAEVIAAVNGVNRSFLDARGLGAYEGKSLQSVSEIYASDGLSTNIKPPPINDGTPNESVADVFVRVTQLMSILETQYSEDTVIIVSPDSDNLTILQAGLVGLDLRRHNELSFEPGEVRFFDPSSIPTYKQPASALYKCLNPPRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0B1</accession>
    <name>A0A103Y0B1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0B1"/>
    <dbReference type="STRING" id="59895.A0A103Y0B1"/>
    <dbReference type="Gramene" id="KVI00170">
        <property type="protein sequence ID" value="KVI00170"/>
        <property type="gene ID" value="Ccrd_021579"/>
    </dbReference>
    <dbReference type="OMA" id="IMIIVCT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000053">
        <property type="entry name" value="Nitrate transporter 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="701" mass="76220" checksum="3C1B6C684BB0819C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y137</accession>
    <name>A0A103Y137_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003370">
        <property type="protein sequence ID" value="KVI00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y137"/>
    <dbReference type="STRING" id="59895.A0A103Y137"/>
    <dbReference type="Gramene" id="KVI00589">
        <property type="protein sequence ID" value="KVI00589"/>
        <property type="gene ID" value="Ccrd_021160"/>
    </dbReference>
    <dbReference type="OMA" id="NGNVICC"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="510"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="5">
        <location>
            <begin position="844"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1093" mass="120482" checksum="5AD94665F2B5EC21" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1B5</accession>
    <name>A0A103Y1B5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Quinonprotein alcohol dehydrogenase-like-superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003342">
        <property type="protein sequence ID" value="KVI00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1B5"/>
    <dbReference type="STRING" id="59895.A0A103Y1B5"/>
    <dbReference type="Gramene" id="KVI00716">
        <property type="protein sequence ID" value="KVI00716"/>
        <property type="gene ID" value="Ccrd_021033"/>
    </dbReference>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000200">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="624"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="760"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="925" mass="102866" checksum="E460F7D0C3476014" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y341</accession>
    <name>A0A103Y341_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002952">
        <property type="protein sequence ID" value="KVI01627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y341"/>
    <dbReference type="Gramene" id="KVI01627">
        <property type="protein sequence ID" value="KVI01627"/>
        <property type="gene ID" value="Ccrd_020099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="326" mass="35733" checksum="BF3458389A280B21" modified="2016-04-13" version="1" fragment="single">FFKTLAISLSTRVSNELGARKPQAAQLAARVVMFLAVIKGILGDPVPCETCDGNGISQFLVMAVKRIRKELKDICSAGSVTQDLWYLPGPDEKIEIAPYGLVENDSEHNICTMGRLKSDIYCFGVVLLETVTGLIAWGNKRREEQRLLSIVAHKGEIHKIIDPRLEQNYPEEGAFKCVALSLRCLANQPKDRPSSDEVLQNLKKIYADSMLVFGVNSGNKRNIISLVAIHCILAQGDSKLSNNTMGNNKFLDATKLPADDKDQRVKELKFADLETATNNFTALGEGGFGGMFLGSVDKNTFAPSTRGVGIAVKRHGVGSRQGHEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y360</accession>
    <name>A0A103Y360_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002849">
        <property type="protein sequence ID" value="KVI01656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y360"/>
    <dbReference type="Gramene" id="KVI01656">
        <property type="protein sequence ID" value="KVI01656"/>
        <property type="gene ID" value="Ccrd_020065"/>
    </dbReference>
    <dbReference type="OMA" id="KTRCSAR"/>
    <dbReference type="OrthoDB" id="1729427at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF10">
        <property type="entry name" value="COPIA-LIKE POLYPROTEIN_RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17684" checksum="3F171AE2A66A08F0" modified="2016-04-13" version="1">MISSYLLHTILELGATAQMTWDHLKETFQDKRVVHLKHQFSHTHQTDFLTIYAYCQHLKMLSDQLANVGARVTNQRLVLQLIFGFSKAYDRVATIIQQFDALALFYRAKSMLTLEGTRKAKQASISPDTHSALFTTGIPSTNIAKSQPRVASQQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3D3</accession>
    <name>A0A103Y3D3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
            <ecNumber evidence="6">2.7.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01002684">
        <property type="protein sequence ID" value="KVI01767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3D3"/>
    <dbReference type="STRING" id="59895.A0A103Y3D3"/>
    <dbReference type="Gramene" id="KVI01767">
        <property type="protein sequence ID" value="KVI01767"/>
        <property type="gene ID" value="Ccrd_019946"/>
    </dbReference>
    <dbReference type="OMA" id="CSINFYW"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17302">
        <property type="entry name" value="PIPKc_AtPIP5K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017163">
        <property type="entry name" value="PIno-4-P-5_kinase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF147">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037274">
        <property type="entry name" value="PIP5K_plant_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="340"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="768" mass="86923" checksum="270E0BE111355F2F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y590</accession>
    <name>A0A103Y590_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_018955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002639">
        <property type="protein sequence ID" value="KVI02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y590"/>
    <dbReference type="STRING" id="59895.A0A103Y590"/>
    <dbReference type="Gramene" id="KVI02765">
        <property type="protein sequence ID" value="KVI02765"/>
        <property type="gene ID" value="Ccrd_018955"/>
    </dbReference>
    <dbReference type="OMA" id="FADTMDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF138">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="303"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="46020" checksum="8A232FA09DFA6AAD" modified="2016-04-13" version="1">MNRKIHPLQTLLFLFLHHTALLARPIFIFYQSVSASLILFSTHLQIDWQSKNSGYLMSSRLLGVEGDGQGNASLLSMESRFQENPGLTERNYLGLSDCSSVDSSTVSSISEVNKNSLNLRATELRLGLPGSQSPERDPESSLTSFDNLDEKPLFPMLPSKDGLCSSSPKIVVSGNKRVFSDTVDSYSEIKGLSEGNWMFGASGAESDASKSLGQVKFSSNSNVNGMISSGGQIMTIKGTASKMPQERPHPICGTNLNNVNSSNPPAAKAQLVGWPPVRSFRKNILATSSKNSDEVDGKPGPGALFVKVSMDGAPYLRKVDLRGYATYQELSSALEKMFTCFTIGQCGSQGAPGKESLSESKLRDLLHSSEYVLTYEDKDGDWMLVGDVPWDMFISSCKRLKIMKGADAIGLAPRAMEKSKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6K2</accession>
    <name>A0A103Y6K2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002351">
        <property type="protein sequence ID" value="KVI03449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6K2"/>
    <dbReference type="STRING" id="59895.A0A103Y6K2"/>
    <dbReference type="Gramene" id="KVI03449">
        <property type="protein sequence ID" value="KVI03449"/>
        <property type="gene ID" value="Ccrd_018258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057196">
        <property type="entry name" value="DUF7874"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37216">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37216:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25284">
        <property type="entry name" value="DUF7874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="256" mass="29080" checksum="24C1453922493F20" modified="2016-04-13" version="1">MEWNHGNELQNHHEGKEKSLSKEEFMRILQDIILDSGVTGKAIKDIFPFIFGIPIVSTFIKQRAAPNVVPSNIFIPAVTSATVFLLTKLNNVYVEHDLRFFLDGFFGRTGKEENKDLEPIIEKCYDQYFADPNKKWNSAEFYHAVCETVEEMNKLIGCTQFRVPKTSTLEQAYHNHHKGKEKSLSKEEFKRILQDIILDSGVTGQGIKDIFLFIFGIPVVTTFIKQRAAPNAVPNDIFIPAVTSASVFLLAKLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6T1</accession>
    <name>A0A103Y6T1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002341">
        <property type="protein sequence ID" value="KVI03578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6T1"/>
    <dbReference type="STRING" id="59895.A0A103Y6T1"/>
    <dbReference type="Gramene" id="KVI03578">
        <property type="protein sequence ID" value="KVI03578"/>
        <property type="gene ID" value="Ccrd_018122"/>
    </dbReference>
    <dbReference type="OMA" id="HYQFDFG"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044526">
        <property type="entry name" value="NAKR1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46119">
        <property type="entry name" value="OS08G0405700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46119:SF12">
        <property type="entry name" value="PROTEIN SODIUM POTASSIUM ROOT DEFECTIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="34294" checksum="FF31EF8B02FEF9E8" modified="2016-04-13" version="1">MKIKTAELFCASPASTAICTTMNQHAMVRRGGGGGGGGSTPRPINHRHHHQYYNNHYQFDFGDKPKFKVPAIPCTSQHHIDPKPYTAYLQKIRKSTSSATTTSTTTATAKSAVARIGDEGALVARRKSSADINDRDAPRGSSSRYLLNNPTIIEDLQDSDDVCNAGALVVSEPAWPEYQTDSPVIKKSLSSSRRSRGYDSPALVKSRSPSLRLDAPTESPGSKSSRSRSRDQVVELRVSIHCKGCEGKVRKHISRMEGVKSFHIDLESKKVTVVGDVTPLSVLSSISKVKNAQFWPSPSPTSASASPSPTPFVAIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7L3</accession>
    <name>A0A103Y7L3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Sucrose synthase</fullName>
            <ecNumber evidence="3 7">2.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_017694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + sucrose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:76533"/>
            <dbReference type="EC" id="2.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.13" evidence="3 7"/>
    <dbReference type="EMBL" id="LEKV01002317">
        <property type="protein sequence ID" value="KVI03999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7L3"/>
    <dbReference type="STRING" id="59895.A0A103Y7L3"/>
    <dbReference type="Gramene" id="KVI03999">
        <property type="protein sequence ID" value="KVI03999"/>
        <property type="gene ID" value="Ccrd_017694"/>
    </dbReference>
    <dbReference type="OMA" id="FRNKDCM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1230:FF:000001">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.330:FF:000001">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000006">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth_GT-B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012820">
        <property type="entry name" value="Sucrose_synthase_pln/cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056736">
        <property type="entry name" value="SUS_EPBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056735">
        <property type="entry name" value="SUS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02470">
        <property type="entry name" value="sucr_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839:SF23">
        <property type="entry name" value="SUCROSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="GT-B_Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24862">
        <property type="entry name" value="SUS_EPBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24861">
        <property type="entry name" value="SUS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose synthase N-terminal" evidence="10">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase EPBD" evidence="11">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase first GT-B" evidence="9">
        <location>
            <begin position="309"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="607"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI03999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="856" mass="98121" checksum="D26FF0D3687EEE0D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8J5</accession>
    <name>A0A103Y8J5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002032">
        <property type="protein sequence ID" value="KVI04491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8J5"/>
    <dbReference type="Gramene" id="KVI04491">
        <property type="protein sequence ID" value="KVI04491"/>
        <property type="gene ID" value="Ccrd_017192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="209" mass="24228" checksum="8E5F9C1EEF87CDFB" modified="2016-04-13" version="1">MSAVMMNRGFDQTDHCFLSISPGGTNWLTLVVDESVKPVIDYVYPSLDIAESKSFDSLNRRKHQREVRNMNIKRTECTACVKFRLMKGTTTYECYDFEEEHNHFLLRHDDIDLTQKGREIKFSDQRFIHDVGISNMGATWAHKLHTSLRGGYEYGGPTVVDFQNYKRDCDNFVSRGDAKVAEVARFNYSEFGNVMSFDATFRTNRLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9U9</accession>
    <name>A0A103Y9U9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Catalase</fullName>
            <ecNumber evidence="4 15">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_016515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4 15"/>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9U9"/>
    <dbReference type="STRING" id="59895.A0A103Y9U9"/>
    <dbReference type="Gramene" id="KVI05171">
        <property type="protein sequence ID" value="KVI05171"/>
        <property type="gene ID" value="Ccrd_016515"/>
    </dbReference>
    <dbReference type="OMA" id="FYNQGAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08154">
        <property type="entry name" value="catalase_clade_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000002">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF23">
        <property type="entry name" value="CATALASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="17">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI05171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="516" mass="59459" checksum="9FF6E1E757B0747A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9Y6</accession>
    <name>A0A103Y9Y6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001885">
        <property type="protein sequence ID" value="KVI05214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9Y6"/>
    <dbReference type="Gramene" id="KVI05214">
        <property type="protein sequence ID" value="KVI05214"/>
        <property type="gene ID" value="Ccrd_016446"/>
    </dbReference>
    <dbReference type="OMA" id="YVAVIAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37714">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37714:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="111" mass="11877" checksum="03AD01E53C979E41" modified="2016-04-13" version="1">MAVSDLVVRNLMMLYLAVIAAIKGYAQVSGRSYGGTSVLILSTAAVGVLLLGTLTWDVSRKAATYGVVTRGGDEVEHEMCRGGICWHGVAVKSPASQLRFRLPQRQIINGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDY2</accession>
    <name>A0A103YDY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDY2"/>
    <dbReference type="STRING" id="59895.A0A103YDY2"/>
    <dbReference type="Gramene" id="KVI07324">
        <property type="protein sequence ID" value="KVI07324"/>
        <property type="gene ID" value="Ccrd_014280"/>
    </dbReference>
    <dbReference type="OMA" id="GEKEVIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000102">
        <property type="entry name" value="Synaptotagmin-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045050">
        <property type="entry name" value="Synaptotagmin_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774:SF188">
        <property type="entry name" value="SYNAPTOTAGMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="67"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="141"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="410" mass="46849" checksum="6AAF82ECCC7EB97C" modified="2016-04-13" version="1">MGVVSTILGAFGFGIGVSLGLVIGYYFFIYFQSSHVENPKIRPLVERDSKSLQQMLPEIPMWVKNPDHDRVDWLNKFVELMWPYLDKTIAEPIIKEQIPKYKIDAVEFDSLTLGDLPPTFQGMKVYTTDEKELIMEPSFKWAGNPNIHVAVKAFGAMKRPVGMLNVKVLRAMKLKKKDFMGASDPYVKLKLTEEKLPSKKTSVKHKNLNPEWNEEFNMVVKDPELQALEIVVYDWEQVGKHDKMGMNVIPLKEVTPEEPKVMTLELLKNMDPNDAQNEKSRGQIMIELVYKPFADDKLPAEAEDGNMIEKAPEGTPEGGGLLVPVKKNRDPRWDEEFAFTLEEPPTNDRMHFEVVSTSSRMGLIHPKESLGYVDIHLGDVVSNKRINEKYNLIDSKNGKLLVEMQWRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE02</accession>
    <name>A0A103YE02_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE02"/>
    <dbReference type="STRING" id="59895.A0A103YE02"/>
    <dbReference type="Gramene" id="KVI07354">
        <property type="protein sequence ID" value="KVI07354"/>
        <property type="gene ID" value="Ccrd_014309"/>
    </dbReference>
    <dbReference type="OMA" id="HDELQVP"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1470:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="289" mass="32019" checksum="FDCC159D239D3C20" modified="2016-04-13" version="1">MNILTGILSSSPPSTLLHFNRFFISSFSSSYETQIQSSWRRRFWRSISMYSSSSSSSSSLYTCASSSRIDPIVSPSVVGEPETITENNKPPKQYPWLIVGLGNPGKLYNRTRHNVGFEMVDAIAEAEGISMSSVSFKAFFGKGCIGNTPLMLAKPQTFMNVSGESVGAIVSFYKIPPKQVLVIYDDLDLPFGKLRLLPKGGHGGHNGMKSVINHLKGSRDFPRLRIGIGRPPGKMEAATYVLRRFNKQESEELDFTFQNGVEALRILLLQGFDKSATFVNSPKPLKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE40</accession>
    <name>A0A103YE40_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12 13">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="2 12 13">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_014205</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="2 12 13"/>
    <dbReference type="EMBL" id="LEKV01001507">
        <property type="protein sequence ID" value="KVI07418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE40"/>
    <dbReference type="STRING" id="59895.A0A103YE40"/>
    <dbReference type="Gramene" id="KVI07418">
        <property type="protein sequence ID" value="KVI07418"/>
        <property type="gene ID" value="Ccrd_014205"/>
    </dbReference>
    <dbReference type="OMA" id="CEEDWKC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="14">
        <location>
            <begin position="236"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI07418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="352" mass="38425" checksum="0A516CFC99E82428" modified="2016-04-13" version="1">MGAESEKWVLMVTARTPTNIAVIKYWGKRDEKLILPINDSISVTLDPNHLCTTTTVSVSPSFVEDRMWLNGKEISLQGGRFQSCLREIRARANDVEDKKKGIKIKKEDWQKLHLHIASYNNFPTAAGLASSAAGLACLVFSLAKLMNLKEDNSQLSAIARQGSGSACRSLYGGFVKWIMGKEENGSDSLAVQLADEKHWDDLVIIIAVVSARQKETSSTSGMRDTVETSALIQHRAKVAYTFDAGPNAVMITRNRKTAALLLQRLLYNFPPQPGTDLDSYVIGDKSILEDAGVKDIKDVEALAPPPETKDNIVGEKSKGDVSYFICTRPGGGPVVLSDEIHALLDPLTGLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YF72</accession>
    <name>A0A103YF72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001437">
        <property type="protein sequence ID" value="KVI07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YF72"/>
    <dbReference type="STRING" id="59895.A0A103YF72"/>
    <dbReference type="Gramene" id="KVI07975">
        <property type="protein sequence ID" value="KVI07975"/>
        <property type="gene ID" value="Ccrd_013659"/>
    </dbReference>
    <dbReference type="OMA" id="CIYWDSQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68399" checksum="547E7475965F9FC4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YG82</accession>
    <name>A0A103YG82_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001110">
        <property type="protein sequence ID" value="KVI08517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YG82"/>
    <dbReference type="STRING" id="59895.A0A103YG82"/>
    <dbReference type="Gramene" id="KVI08517">
        <property type="protein sequence ID" value="KVI08517"/>
        <property type="gene ID" value="Ccrd_013110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="16772" checksum="4B53DF1A091646F4" modified="2016-04-13" version="1">MENENHQMVIEDRDHKFLTRAVEEAYKGVECGDGWPFGALVVHKDEVVVSCHNMVVEHTDPTAHAEVTAIREACKKLNRIDLSDCEMYASSKAEAAIASGIPIDDFISDALRGTGFHEKANLEIKQANGHLTRFQSSEGHSEVTSGFFRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHK5</accession>
    <name>A0A103YHK5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine phosphatase superfamily, clade-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHK5"/>
    <dbReference type="STRING" id="59895.A0A103YHK5"/>
    <dbReference type="Gramene" id="KVI09254">
        <property type="protein sequence ID" value="KVI09254"/>
        <property type="gene ID" value="Ccrd_012362"/>
    </dbReference>
    <dbReference type="OMA" id="VEFRMIQ"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017070">
        <property type="entry name" value="UCP036920_PGAM-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47927:SF2">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47927">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036920">
        <property type="entry name" value="X4Y4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45165" checksum="5BBF1EF6DA7C7E3C" modified="2016-04-13" version="1">MGASESVPVAEDEDEEVEEEEEERDNHGGNDTRRLLGEDDSLMKKVVEQEPELLPCHASASPLSPQPSSFGTPRLAPSIKVWDPCNVLSPPPQFTRSFSDAADDDRTMTEVYLICQGECHVNLRPDLVGGRCPEAALTPNGKRQARALAVFLKSQGIRFNAVYTSPLDRARSTALPICQEMNVSEHLIQASDALQEMSHGLWEGCLRSDVYTPEVLSLMERFQPDFCAPSGESLRQVEFRMLQFLNGTVVCLPEKLRSGFSPTGEEGLTNSIQYRDGPPSPRWDLLTKPKQVLARRKSGKSRLQMVTTTGDHEADDEMSPRDPPNLNHVGRNNNSSSSSSSHCFIASSCVGVFSHSTPIKCLLTGVLGCSPVMSNKICVEDSSVTVLQHSWKTGWQIKRLNDTSHLRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIG9</accession>
    <name>A0A103YIG9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001044">
        <property type="protein sequence ID" value="KVI09699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIG9"/>
    <dbReference type="STRING" id="59895.A0A103YIG9"/>
    <dbReference type="Gramene" id="KVI09699">
        <property type="protein sequence ID" value="KVI09699"/>
        <property type="gene ID" value="Ccrd_011914"/>
    </dbReference>
    <dbReference type="OMA" id="DCFERMS"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.20:FF:000002">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000082">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000292">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057623">
        <property type="entry name" value="PUB12-19-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF351">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25368">
        <property type="entry name" value="PUB10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="622" mass="68299" checksum="9CFCB2727BC2DA88" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIJ3</accession>
    <name>A0A103YIJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIJ3"/>
    <dbReference type="STRING" id="59895.A0A103YIJ3"/>
    <dbReference type="Gramene" id="KVI09771">
        <property type="protein sequence ID" value="KVI09771"/>
        <property type="gene ID" value="Ccrd_011853"/>
    </dbReference>
    <dbReference type="OMA" id="RMPEKWK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000013">
        <property type="entry name" value="TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000018">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="243"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="633"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="847" mass="95481" checksum="DF86D1EDDB1BE976" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIM3</accession>
    <name>A0A103YIM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-locus glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIM3"/>
    <dbReference type="Gramene" id="KVI09762">
        <property type="protein sequence ID" value="KVI09762"/>
        <property type="gene ID" value="Ccrd_011883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="S-locus glycoprotein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="16842" checksum="57C869575B8AD905" modified="2016-04-13" version="1">MECDDSEITLLSQPSSKSCHFTSSITADDQDLIELEFWHHNLESQAQPWIEDWIISLDNCNSYGMCGPHGGSNNLTSPYSGCLKGSPIWLQQKETNANQSYLVNISSTGCVRYRLGAYVSHEPMMSGNKVSCISIDALVLITAATITELAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ43</accession>
    <name>A0A103YJ43_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EF-hand-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ43"/>
    <dbReference type="STRING" id="59895.A0A103YJ43"/>
    <dbReference type="Gramene" id="KVI10085">
        <property type="protein sequence ID" value="KVI10085"/>
        <property type="gene ID" value="Ccrd_011522"/>
    </dbReference>
    <dbReference type="OMA" id="DKEDCIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF31">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="378" mass="43484" checksum="5DDBE31EE7C45B15" modified="2016-04-13" version="1">MAKKRVSRIGNYAAIADPNSFSCTTFNILAPIYKRLVHQDLACRESEIRAYWLSRNERILDLLLCEKSSIICLQEFWVGNDELVNMYDTRLSDAGYINFRLARTNNRGDGLLTAVHKDYFRVIDHREFLFNDFGDRVAQLLHVEVIAPFNQCRNNIACQEILIVNTHLLFPHDSSIDWNGSKRGHVFKFLRSQGFVSSYDTAHQYTDADAHKWVSHRNHRGNICGVDFIWLLNPNKYRKVLKTSWSDAVFGLFKADNDGDYITYSGFCEALRQLNFIGHPNGLSKEETKDLWVQADIDGNGQRIWKPMKYEQTEDAIKIQEDVVNGTQLTIGYNVKNAVLYPSEAEKGTWPDDYSLSDHARLTVAFSPVKMPRSRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJP2</accession>
    <name>A0A103YJP2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS19c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_011279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001023">
        <property type="protein sequence ID" value="KVI10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJP2"/>
    <dbReference type="STRING" id="59895.A0A103YJP2"/>
    <dbReference type="Gramene" id="KVI10334">
        <property type="protein sequence ID" value="KVI10334"/>
        <property type="gene ID" value="Ccrd_011279"/>
    </dbReference>
    <dbReference type="OMA" id="CAISPEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_uS19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="70" mass="8019" checksum="9879443A3A8C46EE" modified="2016-04-13" version="1" fragment="single">MISKLNANDEKHTIKSWSRASMIIPEMVGHRIAIHNGKRHRPIQIKDAMVGHKLGEFALTRARKPQKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJP6</accession>
    <name>A0A103YJP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Microtubule-associated protein, MAP65/Ase1/PRC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_011195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJP6"/>
    <dbReference type="STRING" id="59895.A0A103YJP6"/>
    <dbReference type="Gramene" id="KVI10399">
        <property type="protein sequence ID" value="KVI10399"/>
        <property type="gene ID" value="Ccrd_011195"/>
    </dbReference>
    <dbReference type="OMA" id="NDWYNED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1520:FF:000002">
        <property type="entry name" value="65-kDa microtubule-associated protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI10399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="565" mass="63250" checksum="5C7BCA2E3B04EEB8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKE6</accession>
    <name>A0A103YKE6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B3 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001001">
        <property type="protein sequence ID" value="KVI10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKE6"/>
    <dbReference type="STRING" id="59895.A0A103YKE6"/>
    <dbReference type="Gramene" id="KVI10766">
        <property type="protein sequence ID" value="KVI10766"/>
        <property type="gene ID" value="Ccrd_010815"/>
    </dbReference>
    <dbReference type="OMA" id="IYNDAED"/>
    <dbReference type="OrthoDB" id="1605554at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044837">
        <property type="entry name" value="REM16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391:SF67">
        <property type="entry name" value="TF-B3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="347" mass="39907" checksum="FD8D27E939F0B2AD" modified="2016-04-13" version="1">MDFYKQTLVEQDAEMKQNLASDNNNSKKKRKRKRTPKEPWEPKSKDKQIMSDKPKKCPGKGKRTRVCDIYNDAEDQYMCLERAAFLLERLDAESPKFAKCMLPSNVLYSFWLILPKKFCVMHLPEHDTTVTLVDETGKEFKTNYLKVRHGLSAGWRGFSIAQKLLQGDILFFHLVEPCKLQVNIVRRYGLETIEAAVCLMEMHPRVKKTRTSNYFDKAGEPKKEKLKHKEAKKEDEGKLKNQTPPMLIQTKKGKRTRRSPKKFIARLSLDFCERNVEEDGERVSCVDQCENSSDGLSSEVVQGSTLEMTNQSQPDEVGCYALNLACHEGINCHSTAERIYHSSTVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKL1</accession>
    <name>A0A103YKL1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Expp1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001001">
        <property type="protein sequence ID" value="KVI10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKL1"/>
    <dbReference type="STRING" id="59895.A0A103YKL1"/>
    <dbReference type="Gramene" id="KVI10748">
        <property type="protein sequence ID" value="KVI10748"/>
        <property type="gene ID" value="Ccrd_010837"/>
    </dbReference>
    <dbReference type="OMA" id="DCNLSIQ"/>
    <dbReference type="OrthoDB" id="1885051at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF44">
        <property type="entry name" value="EXPP1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119818" description="Expp1 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25524" checksum="47E4338A2E7B289A" modified="2016-04-13" version="1">MAPKIMLLTVMVTMVIAVRSLDTNSVFNPCSDAKVKRRDGFTFGFAFSSKQSFFKNQIQLSPCDRRLSLGGTDAQLAIFRPKVDELTYLTINGTHFDPAKAGGYMVAFAGRQYAARSIPTFVADKSNIITSFTLVLEFEEGTLVNLHWKKFGCKSCAERSAVCLNNQDCATPISKCKANGGSVDCKISVQLAFSGTDKALDVLNSWYEVEQFRQYSLIGLYQDINDMVMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKS4</accession>
    <name>A0A103YKS4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease P</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_010629</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01000971">
        <property type="protein sequence ID" value="KVI10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKS4"/>
    <dbReference type="STRING" id="59895.A0A103YKS4"/>
    <dbReference type="Gramene" id="KVI10955">
        <property type="protein sequence ID" value="KVI10955"/>
        <property type="gene ID" value="Ccrd_010629"/>
    </dbReference>
    <dbReference type="OMA" id="ACQRETR"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000339">
        <property type="entry name" value="Proteinaceous RNase P 1, chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000002">
        <property type="entry name" value="Proteinaceous RNase P 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="18">
        <location>
            <begin position="89"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PRORP" evidence="17">
        <location>
            <begin position="332"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="567" mass="64560" checksum="A8ECCB987A7A9778" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKY2</accession>
    <name>A0A103YKY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pectin lyase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000971">
        <property type="protein sequence ID" value="KVI10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKY2"/>
    <dbReference type="STRING" id="59895.A0A103YKY2"/>
    <dbReference type="Gramene" id="KVI10973">
        <property type="protein sequence ID" value="KVI10973"/>
        <property type="gene ID" value="Ccrd_010637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="7361" checksum="00B2E669EC2FD909" modified="2016-04-13" version="1">MAAWKEACAVESATLLVPSGCSFMITSTIFSRPCKSGIVFQIDGVVMPPAGPDCWPKKDSNNNKQWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YL95</accession>
    <name>A0A103YL95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton-dependent oligopeptide transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000920">
        <property type="protein sequence ID" value="KVI11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YL95"/>
    <dbReference type="Gramene" id="KVI11092">
        <property type="protein sequence ID" value="KVI11092"/>
        <property type="gene ID" value="Ccrd_010502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="16230" checksum="5017A834FA76F057" modified="2016-04-13" version="1">MAIAAVENNLMTYVINEMHISCLPLIYIGFILLSVQAHLLQLKPPKCNMLVDGDQCTTAKGMKALILYLSLYLVALGRGCVKPNMLAHGANQFNKADSKQCKQLSRYFSSAYLFGYCSHLRCLDLNPLGYDTGFRVSAIVMAMGLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN87</accession>
    <name>A0A103YN87_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN87"/>
    <dbReference type="Gramene" id="KVI12209">
        <property type="protein sequence ID" value="KVI12209"/>
        <property type="gene ID" value="Ccrd_009368"/>
    </dbReference>
    <dbReference type="OMA" id="HELCKRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24299">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24299:SF21">
        <property type="entry name" value="OS09G0441600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="9543" checksum="B2528845FCDD3103" modified="2016-04-13" version="1">MGPLSWLLLATAISALIFRLLNVRHGRKNLPPGPRPWPLIGNLNLIGPLPHQSLHALSQTYGKLMHLKFGSCPVVVASSPEMARQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRK7</accession>
    <name>A0A118JRK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005904">
        <property type="protein sequence ID" value="KVH87714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRK7"/>
    <dbReference type="Gramene" id="KVH87714">
        <property type="protein sequence ID" value="KVH87714"/>
        <property type="gene ID" value="Ccrd_025000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="16175" checksum="6E68FF02E7697BF4" modified="2016-04-13" version="1">MNMLGFWKASSGGLLQMESMVLKLCILNFELRWRRAIMDRPTIGADFVTKELQIDDEIVTVQVLVLTILGFCFWGYNHKSSNNNIEDVKGKPKPPELREINSHEDERRTITLNPKEMKVEGLENCYQGSRRRSKALLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRS2</accession>
    <name>A0A118JRS2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_025416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006319">
        <property type="protein sequence ID" value="KVH87027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRS2"/>
    <dbReference type="STRING" id="59895.A0A118JRS2"/>
    <dbReference type="Gramene" id="KVH87027">
        <property type="protein sequence ID" value="KVH87027"/>
        <property type="gene ID" value="Ccrd_025416"/>
    </dbReference>
    <dbReference type="OMA" id="DETIDHK"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000060">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF221">
        <property type="entry name" value="MYB DOMAIN PROTEIN 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="31415" checksum="A3E43CDADC36898C" modified="2016-04-13" version="1">MEEIGRSCPRGHWRPAEDEKLRQLVQQYGPQNWNTIAEKLQGRSGKSCRLRWFNQLDPRINRGPFTQEEEERLLAAHRLQGNKWALISRLFPGRTDNAVKNHWHVIMARKQREKSKLFDSGFHQRPLSSDEDSSSNYFMKYENGGKEKITSWSCMIPSTMSAAERSSSIEFIGKEEGKGCFNSRMYHHSNSEVSNSSPDHSFFRNYVGVYRVASDCQARKKATFLSPFGSCCRNLQSLVKIRDTIQQERENDETIDHKDIPFIDFLGVGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSH2</accession>
    <name>A0A118JSH2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005596">
        <property type="protein sequence ID" value="KVH88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSH2"/>
    <dbReference type="STRING" id="59895.A0A118JSH2"/>
    <dbReference type="Gramene" id="KVH88062">
        <property type="protein sequence ID" value="KVH88062"/>
        <property type="gene ID" value="Ccrd_024553"/>
    </dbReference>
    <dbReference type="OMA" id="SKYIPWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037489">
        <property type="entry name" value="RAD52-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34050:SF1">
        <property type="entry name" value="DNA REPAIR RAD52-LIKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34050">
        <property type="entry name" value="DNA REPAIR RAD52-LIKE PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="225" mass="24712" checksum="CBCA6A134B092431" modified="2016-04-13" version="1">MKILQSIGVVLDIPAEILSLIPHKFLGKPSKGLLVPETMAFCLMKSLSQKSTNSLSAALRLTSSELVGAKSALSAHGLLYSTKRAKKEEIIAAYEIPAPPPPLDDDIPTSGISRPISEILKELNKKVPDSLIRARTEANGFSIKYIPWHIVNRIMNLHAPEWSGEVRRIDYSADGKSVSVTYRVTIYGTDAEVGYGDPVQKAEAMAFRRACARFGLGLHLYHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTC8</accession>
    <name>A0A118JTC8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005169">
        <property type="protein sequence ID" value="KVH89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTC8"/>
    <dbReference type="STRING" id="59895.A0A118JTC8"/>
    <dbReference type="Gramene" id="KVH89692">
        <property type="protein sequence ID" value="KVH89692"/>
        <property type="gene ID" value="Ccrd_008314"/>
    </dbReference>
    <dbReference type="OMA" id="VEESCKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33983">
        <property type="entry name" value="OS07G0185900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33983:SF1">
        <property type="entry name" value="OS07G0185900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="8456" checksum="14CAA8A32DAC7298" modified="2016-04-13" version="1">MGKYVEILDLGVRMVARFHSHCPQTARMYYHPPSNSVDSGCRSHAPSATEESAKTRRFQASMSFNTREIVFSSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTH3</accession>
    <name>A0A118JTH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005182">
        <property type="protein sequence ID" value="KVH89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTH3"/>
    <dbReference type="Gramene" id="KVH89650">
        <property type="protein sequence ID" value="KVH89650"/>
        <property type="gene ID" value="Ccrd_008353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="19307" checksum="FA57AC5E16F13517" modified="2016-04-13" version="1" fragment="single">MQGFDKNSGPGAGIPKQQPPFGYRPSSQSPSSGTMLNYLDGHPRLTHGMDSTKNKVVESFQRIVMLAKDTPQYLYTDGLVALDRFSGTSLKPEGHRSPALSPIIPSRNPGTEFPAKIQLQDLKRTRSPPLLSTDKELLQNSRTVVGSHSVPLRTKSPPHIYQKSLPGKGFGPSSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU21</accession>
    <name>A0A118JU21_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AWPM-19-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004905">
        <property type="protein sequence ID" value="KVH91764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU21"/>
    <dbReference type="STRING" id="59895.A0A118JU21"/>
    <dbReference type="Gramene" id="KVH91764">
        <property type="protein sequence ID" value="KVH91764"/>
        <property type="gene ID" value="Ccrd_006203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008390">
        <property type="entry name" value="AWPM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33294">
        <property type="entry name" value="AWPM-19-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33294:SF3">
        <property type="entry name" value="AWPM-19-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05512">
        <property type="entry name" value="AWPM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159682" description="AWPM-19-like protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="8999" checksum="192FD91BBAC5F1F9" modified="2016-04-13" version="1">MATGCVVLLSLLAGVVGFVTMVTGMNNVAQWDASNLYAASASSLISWSLTRALETVLIIVTGTQLFSMIAIQSGIEEVSRYSGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU35</accession>
    <name>A0A118JU35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Syntaxin/epimorphin, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_007500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Vesicle trafficking protein that functions in the secretory pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the t-SNARE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU35"/>
    <dbReference type="STRING" id="59895.A0A118JU35"/>
    <dbReference type="Gramene" id="KVH90460">
        <property type="protein sequence ID" value="KVH90460"/>
        <property type="gene ID" value="Ccrd_007500"/>
    </dbReference>
    <dbReference type="OMA" id="KQSGGWA"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009504">
        <property type="term" value="C:cell plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000037">
        <property type="entry name" value="Putative syntaxin-71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF124">
        <property type="entry name" value="SYNTAXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH90460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="29886" checksum="FE76734D4DC1D55B" modified="2016-04-13" version="1">MSVIEILTRVDAICKKYDKYDVEKQRDLNVSGDDAFARLYAAVESDIESALQKAETASNEKNRASVVAINAEIRRTKAKLLEEIPKLQRLAMKKVKGLAPEEFAARNDLVLALPDRIQAIPDGGAAAPKQSGGWAASASRTQIKFDSSDGRFDDEYFQQTEESSQFRNEYEMRKMKQDQGLEMISEGLDTLKNMAQDMNEEVDRQVPLMDEIDDKVDKATSDLRNTNVRLKHTVNQLRSSRNFCIDIILLCVILGIAAYLYNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWB5</accession>
    <name>A0A118JWB5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_003468</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004552">
        <property type="protein sequence ID" value="KVH94466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JWB5"/>
    <dbReference type="Gramene" id="KVH94466">
        <property type="protein sequence ID" value="KVH94466"/>
        <property type="gene ID" value="Ccrd_003468"/>
    </dbReference>
    <dbReference type="OMA" id="KTWIMAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000169">
        <property type="entry name" value="ABC transporter C family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF426">
        <property type="entry name" value="ABC-TYPE XENOBIOTIC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="314"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="628"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="963"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1187"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH94466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1429" mass="159203" checksum="0A6C35C03AD580E7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX81</accession>
    <name>A0A118JX81_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004375">
        <property type="protein sequence ID" value="KVH95861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX81"/>
    <dbReference type="Gramene" id="KVH95861">
        <property type="protein sequence ID" value="KVH95861"/>
        <property type="gene ID" value="Ccrd_002074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="10966" checksum="3E8923C4FB2B3554" modified="2016-04-13" version="1">MRLCPPIFGSFRKAITNIEFEGCFIPKGWKPLGNGILKRVQGISEQLTGGAKAASRIEETPASGDCRRPRTPRTSKATCEMHHGTSRMMSVFTAPGSTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXI2</accession>
    <name>A0A118JXI2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Like-Sm (LSM) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_000841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003865">
        <property type="protein sequence ID" value="KVH97061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXI2"/>
    <dbReference type="STRING" id="59895.A0A118JXI2"/>
    <dbReference type="Gramene" id="KVH97061">
        <property type="protein sequence ID" value="KVH97061"/>
        <property type="gene ID" value="Ccrd_000841"/>
    </dbReference>
    <dbReference type="OMA" id="CDGCDIT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000034">
        <property type="entry name" value="sm-like protein LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="55"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH97061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="148" mass="16082" checksum="638A43D3346A38B5" modified="2016-04-13" version="1" fragment="single">EPVSLSPLTRQSPFSFTSSFKHPPAAGDSASVAPPFRINRLDLLVNFRVSKDQKETVLDLAKFVDKGVQVKLTGGRQVSGTLKGYDQLLNLVLDEAVEFLRDADDPLKTTDQTRRLGLIVCRGTAVMLVSPTDGTEEIANPFIQPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXX1</accession>
    <name>A0A118JXX1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_001018</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004118">
        <property type="protein sequence ID" value="KVH96892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXX1"/>
    <dbReference type="STRING" id="59895.A0A118JXX1"/>
    <dbReference type="Gramene" id="KVH96892">
        <property type="protein sequence ID" value="KVH96892"/>
        <property type="gene ID" value="Ccrd_001018"/>
    </dbReference>
    <dbReference type="OMA" id="HRARERC"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009585">
        <property type="term" value="P:red, far-red light phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase RFWD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF8">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0607">Phytochrome signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 13" id="KW-0853">WD repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00084091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH96892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="697" mass="77827" checksum="D56329A28DFFA047" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZR1</accession>
    <name>A0A118JZR1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_021467</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003393">
        <property type="protein sequence ID" value="KVI00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZR1"/>
    <dbReference type="STRING" id="59895.A0A118JZR1"/>
    <dbReference type="Gramene" id="KVI00283">
        <property type="protein sequence ID" value="KVI00283"/>
        <property type="gene ID" value="Ccrd_021467"/>
    </dbReference>
    <dbReference type="OMA" id="HEIFGAM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000515">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001424">
        <property type="entry name" value="Protein kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000530">
        <property type="entry name" value="receptor protein-tyrosine kinase CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000330">
        <property type="entry name" value="Receptor protein-tyrosine kinase CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057:SF29">
        <property type="entry name" value="OS02G0609900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159827" description="Protein kinase domain-containing protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="647"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="881" mass="98481" checksum="14091DDE8C6F6DA0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZY8</accession>
    <name>A0A118JZY8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003371">
        <property type="protein sequence ID" value="KVI00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZY8"/>
    <dbReference type="STRING" id="59895.A0A118JZY8"/>
    <dbReference type="Gramene" id="KVI00588">
        <property type="protein sequence ID" value="KVI00588"/>
        <property type="gene ID" value="Ccrd_021174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="11328" checksum="9A3A6F95FBD58296" modified="2016-04-13" version="1">MIDVLGRKGMLAEACELVKHLPLEFPAYTWGTMLSCHGVHENFELGEMGARKLSGTQPIYAAMVVLFSNIYVERGMWEDAANVRTLLECHGVKKDLVCSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K060</accession>
    <name>A0A118K060_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Channel protein in tonoplast. These proteins may allow the diffusion of amino acids and/or peptides from the vacuolar compartment to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVI00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K060"/>
    <dbReference type="STRING" id="59895.A0A118K060"/>
    <dbReference type="Gramene" id="KVI00001">
        <property type="protein sequence ID" value="KVI00001"/>
        <property type="gene ID" value="Ccrd_021810"/>
    </dbReference>
    <dbReference type="OMA" id="TECLAVF"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000002">
        <property type="entry name" value="Probable aquaporin TIP1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF55">
        <property type="entry name" value="MAJOR INTRINSIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="250" mass="25534" checksum="25550CBE2690063E" modified="2016-04-13" version="1">MPIRAIAVGRHDELTHPDTLKAGLAEFISTLIFVFAGSGSGMAFSKLTTDGATTPAGLVAASLAHAFALFVAVSIAANISGGHVNPAVTFGAFVGGNITLLRGIVYVIAQLLGSTVACLLLKFVTNNMAVGAFSLSAGVGVTNALVFEIVMTFGLVYTVYATAVDPKKGDLGTIAPIAIGFIVGANILAGGAFTGASMNPAVSFGPALVSWTWANHWIYWVGPLVGGGIAGLIYELLFINQTHDHLPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K353</accession>
    <name>A0A118K353_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001873">
        <property type="protein sequence ID" value="KVI05415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K353"/>
    <dbReference type="STRING" id="59895.A0A118K353"/>
    <dbReference type="Gramene" id="KVI05415">
        <property type="protein sequence ID" value="KVI05415"/>
        <property type="gene ID" value="Ccrd_016302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044676">
        <property type="entry name" value="EOBI/EOBII-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45675:SF123">
        <property type="entry name" value="MYB DOMAIN PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45675">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="175" mass="19898" checksum="35CD4208EA0D0931" modified="2016-04-13" version="1">MRPTRKMTTSCNGKELGELRRGPWTLDEDNLLVHYITCHGEGRWNSLAKSSVEHSSPSSLSTSTSTMEADQKNLIPQPQGKETPTENMNSSSSNCSSDSTGIMLPYLSENSLKNNNYFVENSNFEVMSFNQSNTQDLRSTDMSILDFQLTDVDWMNNDLVGDTFWSMDELWQFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3M8</accession>
    <name>A0A118K3M8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_015502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001847">
        <property type="protein sequence ID" value="KVI06152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3M8"/>
    <dbReference type="Gramene" id="KVI06152">
        <property type="protein sequence ID" value="KVI06152"/>
        <property type="gene ID" value="Ccrd_015502"/>
    </dbReference>
    <dbReference type="OMA" id="CTITSDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000003">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF22">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI06152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36903" checksum="8557F8B0A39C1538" modified="2016-04-13" version="1">MVGNLAHLTLAFGLLGNIVSFMVFLAPMYASYICFFSFYLFSKPTFYRVYKKKSTEGFQSEPYVVGLFSAMLWIYYALLKSNVLLLITINSVGCFIETLYICFFLVYAPKKARKVGLTKRNLVMQMESLKLIVLLIVVGFGLIVVLTQFFASGVTRGVIVGWICLVFSLCVFVAPLGVLRQVIKTKSVEYMPILLSVALTLSAVMWFFYGLLLGDFNIAIPNVLGFTFGIIQMILYFVYKNKKPIINEKMSEKGEQKYTIGKMEEQKMVEVKDHKTIDVVKLSANLLSPDVLPVVAKLKENEHDAVPVAVHEPEARPTVPNHIIEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K559</accession>
    <name>A0A118K559_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_013030</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001104">
        <property type="protein sequence ID" value="KVI08596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K559"/>
    <dbReference type="Gramene" id="KVI08596">
        <property type="protein sequence ID" value="KVI08596"/>
        <property type="gene ID" value="Ccrd_013030"/>
    </dbReference>
    <dbReference type="OMA" id="CRTEKDD"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000187">
        <property type="entry name" value="E3 ubiquitin-protein ligase ATL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF632">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159968" description="RING-type E3 ubiquitin transferase" evidence="17">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="336" mass="37227" checksum="574CAD0E38D0ECFF" modified="2016-04-13" version="1">MNGSSISILRQLFIVLPALLFPRAAAQSIRGSSSTSAYPYEIGGNVSAPVKIILSVLIFGMFLIAFFSLYIRKCIEDSAIESRRPILIANNHRARLKFPCGLDRSVVDSFPVFLYSDVKVLKIGNGALECAVCISEFDDDERLRFLPKCHHVFHPDCIDAWLASHTTCPVCRDDLTTANLNDNSESNDESTHSQINDSTSENGSQNHSIIHVEEERAAPKFPRSHSTGHSLILPGENCDRYTLRFPEEVRKQIVTLKRAKSCGCGVDLPADGSSRRGWRLQSDGSRGGRRWNPDRLCGRSDLWNMRVTRMPAFIAKSDSAGKMDPAQSSSSNTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K612</accession>
    <name>A0A118K612_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sedoheptulose-1,7-bisphosphatase, chloroplastic</fullName>
            <ecNumber evidence="6">3.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SED(1,7)P2ase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Sedoheptulose bisphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ccrd_011694</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17461"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:58335"/>
            <dbReference type="EC" id="3.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.37" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01001037">
        <property type="protein sequence ID" value="KVI09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K612"/>
    <dbReference type="STRING" id="59895.A0A118K612"/>
    <dbReference type="Gramene" id="KVI09903">
        <property type="protein sequence ID" value="KVI09903"/>
        <property type="gene ID" value="Ccrd_011694"/>
    </dbReference>
    <dbReference type="OMA" id="PNWTVGT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000010">
        <property type="entry name" value="Sedoheptulose-1,7-bisphosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000008">
        <property type="entry name" value="Sedoheptulose-1,7-bisphosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF35">
        <property type="entry name" value="SEDOHEPTULOSE-1,7-BISPHOSPHATASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="20">
        <location>
            <begin position="59"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="21">
        <location>
            <begin position="240"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KVI09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="377" mass="40878" checksum="C9F9C08B24F268CA" modified="2016-04-13" version="1">METGVACFARGTILPTIASQHSTSFASPWSVSPSFTTRALRVMPRSSFKVSKAQNSSFVTKCEIGESLEEFLSKATPDKGLIRLLTCMSEAIRTIAFKVRTASCGGTACVNSFGDEQLAVDMLADKLLFDALTHSHFCKYACSEEVPELQDMGGPVEAFDPLDGSSIVDTNFTVGTIFGVWPGDKLTGVTGGDQVAAAMGIYGPRTTYVLAIKGFPGTHEFLLLDEGKWQHVKETTEISEGKMFSPGNLRATFDNPEYDKLINYYVKEKYTLRYTGGMVPDVNQIIVKEKGVFTNVISPTTKAKLRLLFEVAPLGLLIENAGGYSSDGTKSVLDKVIVNLDDRTQVAYGSKNEIIRFEETLYGSSRLKSGVPVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K641</accession>
    <name>A0A118K641_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_011579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001031">
        <property type="protein sequence ID" value="KVI10037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K641"/>
    <dbReference type="Gramene" id="KVI10037">
        <property type="protein sequence ID" value="KVI10037"/>
        <property type="gene ID" value="Ccrd_011579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="17692" checksum="B4375F24F48106AB" modified="2016-04-13" version="1">MDSTETRFLFKYQPQLGVLEKAYLPQGMMEVRLARQVLDLMAVEHLWIALNGMMVDRPASASWPVKSTNTATFPNIDPLRPYPVLGPAKKEPKSVTETKRNHGSVLRAILQAKVSNAIASIYGRMGGFVGPVPMTGLLPGGSEPSMRYHGSTLIDFGFTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6E8</accession>
    <name>A0A118K6E8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyphenol oxidase, central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_011039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001013">
        <property type="protein sequence ID" value="KVI10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K6E8"/>
    <dbReference type="Gramene" id="KVI10560">
        <property type="protein sequence ID" value="KVI10560"/>
        <property type="gene ID" value="Ccrd_011039"/>
    </dbReference>
    <dbReference type="OMA" id="RIVYMEE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022740">
        <property type="entry name" value="Polyphenol_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022739">
        <property type="entry name" value="Polyphenol_oxidase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF97">
        <property type="entry name" value="CATECHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12142">
        <property type="entry name" value="PPO1_DWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12143">
        <property type="entry name" value="PPO1_KFDV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="8">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="520" mass="57189" checksum="8BA93FAECBCF4D54" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L9</accession>
    <name>A0A118K6L9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_010711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01000986">
        <property type="protein sequence ID" value="KVI10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L9"/>
    <dbReference type="STRING" id="59895.A0A118K6L9"/>
    <dbReference type="Gramene" id="KVI10888">
        <property type="protein sequence ID" value="KVI10888"/>
        <property type="gene ID" value="Ccrd_010711"/>
    </dbReference>
    <dbReference type="OMA" id="AKMEMST"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="263" mass="29483" checksum="2B57AADF5408B1A5" modified="2016-04-13" version="1" fragment="single">MAATRVMVSVSSSSSLLFKAAATPLLKTNRLRPCFNTHNRLVSSNRFFTCRALYKPDFQIKEEGQPETLDYRVFFVDNSGGRFCSIELHVYTVQVSPWHDVPLHVGDGTFNFIVEIPKESSAKMEVATDEIYTPIKQDTKKGNLRYYPYNINWNYGLLPQTWEDPSLANPDVDGAFGDNDPVDVVEIGESHGKVGQLMKVKPLGCLAMIDEGELDWKIVAISLDDPRASLGTLMAIRDWFRDYKIPDGKPANKFGLGNKAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7G7</accession>
    <name>A0A118K7G7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01000010">
        <property type="protein sequence ID" value="KVI12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI12198">
        <property type="protein sequence ID" value="KVI12198"/>
        <property type="gene ID" value="Ccrd_009417"/>
    </dbReference>
    <dbReference type="OMA" id="DQHHGFR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF21">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="99"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="655" mass="71234" checksum="AF5FCB1E5461DF52" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBM0</accession>
    <name>A0A124SBM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_006927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005082">
        <property type="protein sequence ID" value="KVH91060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBM0"/>
    <dbReference type="STRING" id="59895.A0A124SBM0"/>
    <dbReference type="Gramene" id="KVH91060">
        <property type="protein sequence ID" value="KVH91060"/>
        <property type="gene ID" value="Ccrd_006927"/>
    </dbReference>
    <dbReference type="OMA" id="HMANRMG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000228">
        <property type="entry name" value="dynamin-related protein 1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF159">
        <property type="entry name" value="PHRAGMOPLASTIN DRP1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="10">
        <location>
            <begin position="81"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH91060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="635" mass="71048" checksum="C0D173F4640F72A5" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEE9</accession>
    <name>A0A124SEE9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003407">
        <property type="protein sequence ID" value="KVH99892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEE9"/>
    <dbReference type="STRING" id="59895.A0A124SEE9"/>
    <dbReference type="Gramene" id="KVH99892">
        <property type="protein sequence ID" value="KVH99892"/>
        <property type="gene ID" value="Ccrd_021866"/>
    </dbReference>
    <dbReference type="OMA" id="GNKFLMW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="266" mass="30034" checksum="631C91EFE2A7643C" modified="2016-04-13" version="1">MRTSNHLIGMLNFLTFLLSVPILGGGIWLSTRANNTDCMSFLQWPLIVIGVAIMVVSLAGFAGACYRNTFLMYLYLWAMFFIIAVLIGFVIFAYVVTDKGSGRSVPNRAYSDYYLPDYSGWLKDRVASDSYWQKISSCVRDSKACRKTGRLSGCCKPPTECGFSYVNETTWNPINTALAVNNRDCLRWSNDQEQLCYACNSCKAGVLAGVKKSWRKVSIINIVVLVILVIAYVVACAAFRNNRRMDNDEPYGETRMEKSRPSWIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEJ9</accession>
    <name>A0A124SEJ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="15">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_021448</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01003391">
        <property type="protein sequence ID" value="KVI00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEJ9"/>
    <dbReference type="STRING" id="59895.A0A124SEJ9"/>
    <dbReference type="Gramene" id="KVI00331">
        <property type="protein sequence ID" value="KVI00331"/>
        <property type="gene ID" value="Ccrd_021448"/>
    </dbReference>
    <dbReference type="OMA" id="ITDVMAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000331">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120676" checksum="00C8F07A438BA2EC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEW7</accession>
    <name>A0A124SEW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">xyloglucan:xyloglucosyl transferase</fullName>
            <ecNumber evidence="1">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>breaks a beta-(1-&gt;4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan.</text>
            <dbReference type="EC" id="2.4.1.207"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01003109">
        <property type="protein sequence ID" value="KVI01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEW7"/>
    <dbReference type="SMR" id="A0A124SEW7"/>
    <dbReference type="STRING" id="59895.A0A124SEW7"/>
    <dbReference type="Gramene" id="KVI01381">
        <property type="protein sequence ID" value="KVI01381"/>
        <property type="gene ID" value="Ccrd_020334"/>
    </dbReference>
    <dbReference type="OMA" id="FESTHDF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044042">
        <property type="term" value="P:glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="193" mass="21930" checksum="A9906FAFC6C5F900" modified="2016-04-13" version="1" fragment="single">MRIHSSLWNADDWATRGGLVKTDWSKAPFTASYRNFNAEACVVAPGKPSSCGGGSILSYVSVFRFYVDEIPIREFRNDEAIGVPFPNSQPMRIHSSIWNADEWATRGGLVKTDWSRAPFTASYRSFSADACIWSSSRGSSCPSNSTKRGWFREKFNTAAVRKLKWAQKYHRVYNYCTDRWRFPAGPAPECKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF92</accession>
    <name>A0A124SF92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZF-HD homeobox protein, Cys/His-rich dimerization domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF92"/>
    <dbReference type="STRING" id="59895.A0A124SF92"/>
    <dbReference type="Gramene" id="KVI02492">
        <property type="protein sequence ID" value="KVI02492"/>
        <property type="gene ID" value="Ccrd_019163"/>
    </dbReference>
    <dbReference type="OMA" id="VIVRRCH"/>
    <dbReference type="OrthoDB" id="682018at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006456">
        <property type="entry name" value="ZF_HD_homeobox_Cys/His_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01566">
        <property type="entry name" value="ZF_HD_prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948:SF162">
        <property type="entry name" value="MINI ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04770">
        <property type="entry name" value="ZF-HD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51523">
        <property type="entry name" value="ZF_HD_DIMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZF-HD dimerization-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="12821" checksum="BB9CBFFFA99446A6" modified="2016-04-13" version="1">MTKRRVVLKREEPPPPPLPPPPPPSMDSANSSNTMRTHVRYGECQRNHAANIGGYAVDGCREFMAAAGDQEEEETEASLTCAACGCHRNFHRRVVETEVVCSSDDSWPSSSSSPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFF5</accession>
    <name>A0A124SFF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002571">
        <property type="protein sequence ID" value="KVI03076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFF5"/>
    <dbReference type="STRING" id="59895.A0A124SFF5"/>
    <dbReference type="Gramene" id="KVI03076">
        <property type="protein sequence ID" value="KVI03076"/>
        <property type="gene ID" value="Ccrd_018635"/>
    </dbReference>
    <dbReference type="OMA" id="ECNERTQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140566">
        <property type="term" value="F:histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056280">
        <property type="entry name" value="AIPP2-like_SPOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049914">
        <property type="entry name" value="PHD1-3/5-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33304">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33304:SF18">
        <property type="entry name" value="CHROMATIN REGULATOR PHD FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23121">
        <property type="entry name" value="SPOC_AIPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AIPP2-like SPOC-like" evidence="7">
        <location>
            <begin position="287"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="487" mass="54752" checksum="6816246240A8F299" modified="2016-04-13" version="1">MWKRSEVNVCQTCGDEGYTNAFVYCVKCLDFVIHRYCLNVMPTTFNERVLWYCEHCKPTVGNQVTSPEVRSSRSQKEEAASSGQVKSTNHKKKQKERDIASIIAGTVVVNCQESTTEPEAECILPTDSLKEASMKLNSRHKRITSSKPGKRKKIAARLDAKKKEHKLRSGLKTETQKACTKMADSVKHSKNRIHHTASNLKNNKGVVDSLDEQTHESRPSQPPRGHKKLSSDSPSMKEESDKTTNHECQAEKANKLQTKQDIVFNLSQSADFENNVPCGQPIIDPVWRGSFSILDRDYDLFEGFVAHLSTKACDKVYKEANMLPSLLQLEMHPKTVLWPKSFQECEPSDVNIALYFFPGDQINEKDFDHLVIDMMDKGLAMRAMATNAELLIFTSRVLPQLFSRFQGKYYLWGVFKAKKNGSSSVASHNLSVVNNSDKHDLTKGSPNEVFDVKAVLTKVKTLDSHSPRSPFSNNGENGVDMDPESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGG2</accession>
    <name>A0A124SGG2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">High-affinity nitrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_015380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nitrate transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001842">
        <property type="protein sequence ID" value="KVI06273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SGG2"/>
    <dbReference type="Gramene" id="KVI06273">
        <property type="protein sequence ID" value="KVI06273"/>
        <property type="gene ID" value="Ccrd_015380"/>
    </dbReference>
    <dbReference type="OMA" id="CLAETSH"/>
    <dbReference type="OrthoDB" id="2015470at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010167">
        <property type="term" value="P:response to nitrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016605">
        <property type="entry name" value="Transptr_NO3_Nar2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806:SF1">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34806">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16974">
        <property type="entry name" value="NAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012939">
        <property type="entry name" value="Transpt_NO3_Nar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017107256" description="High-affinity nitrate transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="204" mass="22729" checksum="ED76901710E65F63" modified="2016-04-13" version="1">MEVHSSFLVASILFSCFAATCTGVTFSSLQKTLVVTASSTQDQVLKAGEEQITVTWAFNQTFPAGTDSAYRTVKVKLCYAPISQKDRSWRKTEXEMKKDKTCQHKIVSRPYSASNNSFSWTIMRDIPSATYFVRAYVFNSQDQEVAFGQNTNVERATNLFEVQAITGRHASLDIASICFSAFSIVALAGFFYMEKSKGKASQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHG3</accession>
    <name>A0A124SHG3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001060">
        <property type="protein sequence ID" value="KVI09478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHG3"/>
    <dbReference type="STRING" id="59895.A0A124SHG3"/>
    <dbReference type="Gramene" id="KVI09478">
        <property type="protein sequence ID" value="KVI09478"/>
        <property type="gene ID" value="Ccrd_012136"/>
    </dbReference>
    <dbReference type="OMA" id="GFQAWKE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47025:SF7">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASE WITH RING_FYVE_PHD-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47025">
        <property type="entry name" value="AUTOIMMUNE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="769"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="772"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="843"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1116" mass="122737" checksum="89058D22FB2AF5E3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D8Q4</accession>
    <name>A0A103D8Q4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidative stress 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011432">
        <property type="protein sequence ID" value="KVD99855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D8Q4"/>
    <dbReference type="STRING" id="59895.A0A103D8Q4"/>
    <dbReference type="Gramene" id="KVD99855">
        <property type="protein sequence ID" value="KVD99855"/>
        <property type="gene ID" value="Ccrd_024106"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694201at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF103">
        <property type="entry name" value="PROTEIN OXIDATIVE STRESS 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVD99855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19142" checksum="255DD4FB49D3195F" modified="2016-04-13" version="1">MGFISSEKKSQLEQTRWVLTEVVHVTTDGYGSDIVEECSNDLSNSLESSSSSEMLDNTSTSSSLASSSSVLSHTGPLYELSELMKQLPIKRGLSKYYQGKSESFGSLANLKSFQDLAKRSRWSTKSPFRSQSQNQTLIPKGIIVKNKKNSLFSSLGKIKMDSLLDTISVQNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103QDW3</accession>
    <name>A0A103QDW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpene synthase, metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_026394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008103">
        <property type="protein sequence ID" value="KVG47623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103QDW3"/>
    <dbReference type="Gramene" id="KVG47623">
        <property type="protein sequence ID" value="KVG47623"/>
        <property type="gene ID" value="Ccrd_026394"/>
    </dbReference>
    <dbReference type="OMA" id="IMDTWKK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000007">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF9">
        <property type="entry name" value="TERPENE SYNTHASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="4">
        <location>
            <begin position="396"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="5">
        <location>
            <begin position="632"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVG47623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="929" mass="107303" checksum="463A2F5661B6979C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103S4T4</accession>
    <name>A0A103S4T4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007615">
        <property type="protein sequence ID" value="KVG79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103S4T4"/>
    <dbReference type="STRING" id="59895.A0A103S4T4"/>
    <dbReference type="Gramene" id="KVG79634">
        <property type="protein sequence ID" value="KVG79634"/>
        <property type="gene ID" value="Ccrd_026194"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931102at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132">
        <property type="entry name" value="OSJNBB0118P14.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132:SF53">
        <property type="entry name" value="SERINE-RICH PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="199" mass="21792" checksum="69A75FA8F45762BF" modified="2016-04-13" version="1">MATSSRKSKGSVLPLASMFHCSILPSGRFASSTTAGFYSSPSSSYIHRRPTSSTRVNLHGLTSMTSSSVSFSIENRSGSAIRSMVVSPRDQVVREQNGRTLPKKMCMCSQTMHPGSFRCSLRKTYNNSHSMTSYSPNRLNARRSAMTNSLVRIATVEGGDLVKRALAALIRPSSHQQRQRSAFQPRPSRLSILSNADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WLV0</accession>
    <name>A0A103WLV0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006521">
        <property type="protein sequence ID" value="KVH74768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WLV0"/>
    <dbReference type="Gramene" id="KVH74768">
        <property type="protein sequence ID" value="KVH74768"/>
        <property type="gene ID" value="Ccrd_025564"/>
    </dbReference>
    <dbReference type="OMA" id="WRPSLCT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH74768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="12346" checksum="25563789833CF0FC" modified="2016-04-13" version="1">MRFLITLVACCGIDQYQSSVALNSKRNDDDKSLVVGLVRENKLLGGGKMGRNSWRQPVQWRPSLCTISEEDVIKAERIQLYVKPGNKGMKNVKLSTSSYTPYGYRNEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBR4</accession>
    <name>A0A103XBR4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor GRAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_024915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005819">
        <property type="protein sequence ID" value="KVH87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBR4"/>
    <dbReference type="STRING" id="59895.A0A103XBR4"/>
    <dbReference type="Gramene" id="KVH87798">
        <property type="protein sequence ID" value="KVH87798"/>
        <property type="gene ID" value="Ccrd_024915"/>
    </dbReference>
    <dbReference type="OMA" id="RCYKTLT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="403" mass="46005" checksum="E290ADDFFB74EFBB" modified="2016-04-13" version="1">MERTHHSPYTNHQTTSTPQSNHTYSDSGEGCEVEDKWAPRLLRECARAIYVKDSAKINHLLWMLNELSSPYGDCDQKLASYFLQALFCKATESGPRCYKTLVSVADKSHCFDSARKLILKFQEVSPWTTFGHVASNGAILEAFDGETKLHIIDISNTLCTQWPTLLEALATRSDETPSLKLTVVVTASLVRSVMKEITQRMEKFARLMGVPFEFNVITGSNRLLGQLTKEELGVHEDEAIAVNCIGALRRVEVEEREDVIRLFSSLKPRVVTIVEEEADFASSRSDFAKCFEECLRYYTLYFEMLEESFTPTSNERLMLERECSRSIVRVLSCDDTQNIGSGDCERREKGNQWCQRLKEQFSPVGFSDDVVDDVKALLRRTRLWDKYQKCGDKMPQHNTQAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCE3</accession>
    <name>A0A103XCE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005549">
        <property type="protein sequence ID" value="KVH88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCE3"/>
    <dbReference type="STRING" id="59895.A0A103XCE3"/>
    <dbReference type="Gramene" id="KVH88153">
        <property type="protein sequence ID" value="KVH88153"/>
        <property type="gene ID" value="Ccrd_024463"/>
    </dbReference>
    <dbReference type="OrthoDB" id="773121at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000005">
        <property type="entry name" value="ethylene-responsive transcription factor RAP2-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF189">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="31089" checksum="FEC57BD1CD1FF90D" modified="2016-04-13" version="1">MSIPVADGGVKGRRKKASNSRGHPRFVGVRQRPSGRWVAEIKDSLQKVRLWLGTFDTADDAARAYDDAARSLRGANARTNFEPPDAVRCSPENSEPFCFEEACRSEDAENGLVGALRAKLFLGSSSKHAAAKGKSLGFPASQHHPVGVKRKTPSTAVPPSVITNLPLVNHDLIRVASPINLDEGQWRNTCYEPQPWSATTASSSAAKNQVIDVLSSLLDTSLMDSLWPLTNEAIEATVVKTATGIWQEQQVLHCDNSWGGSGSGGGDQALNGAPNASSWDPFIYLNSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD22</accession>
    <name>A0A103XD22_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WEB family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WEB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005391">
        <property type="protein sequence ID" value="KVH88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD22"/>
    <dbReference type="Gramene" id="KVH88498">
        <property type="protein sequence ID" value="KVH88498"/>
        <property type="gene ID" value="Ccrd_026672"/>
    </dbReference>
    <dbReference type="OMA" id="TCEAVQF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009904">
        <property type="term" value="P:chloroplast accumulation movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009903">
        <property type="term" value="P:chloroplast avoidance movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008545">
        <property type="entry name" value="Web"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054">
        <property type="entry name" value="HEAVY CHAIN, PUTATIVE, EXPRESSED-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054:SF98">
        <property type="entry name" value="WEB FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05701">
        <property type="entry name" value="WEMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="85"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64915" checksum="47B8421F637D0934" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDK6</accession>
    <name>A0A103XDK6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_025820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005341">
        <property type="protein sequence ID" value="KVH88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XDK6"/>
    <dbReference type="Gramene" id="KVH88759">
        <property type="protein sequence ID" value="KVH88759"/>
        <property type="gene ID" value="Ccrd_025820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647:SF5">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="259" mass="28851" checksum="5EC807923BCBC05D" modified="2016-04-13" version="1">MLNSGLDSIRAAMAVFPGARXMEEGLAEAIDEGRIGPRDDSKNHTGRENPNWKQVFFATTTRRDVGGDGGGGGVLATTLLDHQSINHTLFNNFPTGNCSTNQRKRGIEYVMNQFMSNHHQQHSISSQSSGFASLLSEYLSNLIHQQRDEIEHYLQVQEEELRRKLAEKRQQHYFVLIRAAKESASQMIKGQGGEGVLQADLEARALQLSTEAQVWQAKARVQEAVAAALQAQLQRAIITILNAMYNDSQKFQVLTDNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEB3</accession>
    <name>A0A103XEB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_008854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005306">
        <property type="protein sequence ID" value="KVH89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEB3"/>
    <dbReference type="STRING" id="59895.A0A103XEB3"/>
    <dbReference type="Gramene" id="KVH89165">
        <property type="protein sequence ID" value="KVH89165"/>
        <property type="gene ID" value="Ccrd_008854"/>
    </dbReference>
    <dbReference type="OMA" id="MRGHDFV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12156">
        <property type="entry name" value="HPPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000213">
        <property type="entry name" value="Putative 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF270">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE HPR3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="57"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="125"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="366" mass="41083" checksum="392A6390B4381385" modified="2016-04-13" version="1">MGKHDPSQKEKIADDLPSVLLLRQPFVFKVYERQFSEKFRFLKPWESSLPLHQFLSTHAASVQAAFFSAGRPITTDILQNLPELRFIMTSSAGLDHIDLNECKRRGIKVANAGSIFSEDVADTAVGLLIDVLRRVSAANWFVKAGLWQQKGDYPLGHKLGGKRVGVVGMGSIGLNVAKKLNTFGCIISYNSRKKKPHVTFPFYPNIQELAANCEIIIICCALMDQTRHMIDKNVMMALGKEGIIVNVARGAIINEKELVQCLLKGEIAGAGLDVFENEPNVPEELFHLDNVVMTPHNAVMTEESMNNLYEIVIGNLEAFFSNKPLIFEVVQDSGEHFGSKFLEIESWFQRCSSAFRYRDLVYDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEM3</accession>
    <name>A0A103XEM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_008727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005267">
        <property type="protein sequence ID" value="KVH89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEM3"/>
    <dbReference type="STRING" id="59895.A0A103XEM3"/>
    <dbReference type="Gramene" id="KVH89286">
        <property type="protein sequence ID" value="KVH89286"/>
        <property type="gene ID" value="Ccrd_008727"/>
    </dbReference>
    <dbReference type="OMA" id="KQSEHCR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF3">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="4">
        <location>
            <begin position="620"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="714" mass="80807" checksum="56A8D55C9843033C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEU8</accession>
    <name>A0A103XEU8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_008595</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005212">
        <property type="protein sequence ID" value="KVH89416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEU8"/>
    <dbReference type="STRING" id="59895.A0A103XEU8"/>
    <dbReference type="Gramene" id="KVH89416">
        <property type="protein sequence ID" value="KVH89416"/>
        <property type="gene ID" value="Ccrd_008595"/>
    </dbReference>
    <dbReference type="OMA" id="GYTCKVG"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF123">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="17">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="471" mass="52513" checksum="4D9299A04FA23009" modified="2016-04-13" version="1">MASSRSSRTRVGRYELGRTLGEGTFAKVKFARNTETGENVAIKILDKEKVLKHKMINQIKREISTMKLIRHPNVIRMYEVMASKTKIYIVLEFVTGGELFDKIATRGRLKEDEARKYFQQLINTVDYCHSRGVFHRDLKPENLLLDASGCLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEESNLMALYKKINKADFSCPPWFSSSAKKLIKRILDPNPVTRITTSEVIQNEWFKKGYVPPRFEQEDVSLDDVDAIFNEAGDSQVLVVERRDERPTAPVTMNAFELISKSQGLNLSSLFEKQMGLVKRETRFTSKCPANEIISKIEEAALPLGFDVKKNNYKLKLQGEKTGRKGHLSVATEIFEVAPSLHMVEVRKSGGDTLEFHKFYKNLSTGLQDIVWRNGDEANGDLTGAAPAAPSSPSPAPSSPSPAPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFG3</accession>
    <name>A0A103XFG3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ccrd_008196</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005138">
        <property type="protein sequence ID" value="KVH89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XFG3"/>
    <dbReference type="Gramene" id="KVH89788">
        <property type="protein sequence ID" value="KVH89788"/>
        <property type="gene ID" value="Ccrd_008196"/>
    </dbReference>
    <dbReference type="OMA" id="HPVDWWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF467">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="53"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="432"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="769"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KVH89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1473" mass="168396" checksum="A3040E376918A8BD" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGZ6</accession>
    <name>A0A103XGZ6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_007422</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGZ6"/>
    <dbReference type="STRING" id="59895.A0A103XGZ6"/>
    <dbReference type="Gramene" id="KVH90561">
        <property type="protein sequence ID" value="KVH90561"/>
        <property type="gene ID" value="Ccrd_007422"/>
    </dbReference>
    <dbReference type="OMA" id="AMNHIWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000015">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000056">
        <property type="entry name" value="calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="144"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="595" mass="66849" checksum="D39115BC849C7B42" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHB0</accession>
    <name>A0A103XHB0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHB0"/>
    <dbReference type="Gramene" id="KVH90765">
        <property type="protein sequence ID" value="KVH90765"/>
        <property type="gene ID" value="Ccrd_007227"/>
    </dbReference>
    <dbReference type="OMA" id="YLESKFW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46863">
        <property type="entry name" value="OS09G0572100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46863:SF1">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="456" mass="50775" checksum="84D047CD752CE3FB" modified="2016-04-13" version="1">MCRTKMAVNADEPSSTRRRSSRTTTMATPTRTSSKSQTGRYPSSTNLTSTSYSYGDGTGTGTGSSYRLDSSIATAEASVSTRTSLSSLRNSLPEDTHIYDVSEIRSATNNFLAKRFSSSSSSPSWRCSLRGKEVVVFQRKFRRPIKDSELREKLSVIYRSHHMSIIKLLGASISGDYIYLAYDFMPGGNLADCLRNKRNPDFTVLSTWMSRMQIATDLASGLDYIHNNAGLKINLVHKYVKSSSVIVTEPSFNAKICHFGTAELCGETVIEPKFVKEEKIGHEISEVVSPESSPPKNLTRSDSRAMRFEGTKGYMGPEFRGLATQKSDVYAFGVVILELLSGEEPVRYKYDKEKGNHIKILVVDTARHAVEGGGKDESEIEGRLRQWVDRRLKDSFPVAVAEKLTRIALDCVDNDPNKRPNMSRVAGKISKLYLDSRKWADTIQIPSDFTSSFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIW6</accession>
    <name>A0A103XIW6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_006476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004935">
        <property type="protein sequence ID" value="KVH91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIW6"/>
    <dbReference type="STRING" id="59895.A0A103XIW6"/>
    <dbReference type="Gramene" id="KVH91502">
        <property type="protein sequence ID" value="KVH91502"/>
        <property type="gene ID" value="Ccrd_006476"/>
    </dbReference>
    <dbReference type="OMA" id="SYPLAVW"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="119"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="47100" checksum="E1F1B81A90ED1986" modified="2016-04-13" version="1">MLLNLLPSSSVTFSKSHHKYPINNPSNLASKTSIPHRLTQSKLKVSILNQIHNHPFEHPSSTPTSQIYGVSKFLKTPFRFGSFGGKPTSQIVKSASESSETPQDLTPDGEIEKKSNKTLQLAIVFGFWYFQNIVFNIYNKKALNIFPYPWLLASFQLFVGSLWMLVLWGFKLQPCPKIDKSFIIALLGPALFHTIGHISACVSFSKVAVSFTHVIKSAEPVFSVVFSSALGTTYPLSVWLSILPIVMGCSLAAVTEVSFNLGGLWGALISNVGFVLRNIYSKKSLQNFKQVNGLNLYGWITILSFFYLFPVAIFVEGSQWVPGYYKAIETIGKPSTFYLWVMLSGVFYHLYNQSSYQALDDISPLTFSVGNTMKRVVVIISTVLVFRNPVRPLNGLGSAIAILGTFLYSQATSKKKAAVEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJV5</accession>
    <name>A0A103XJV5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_005868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004853">
        <property type="protein sequence ID" value="KVH92105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJV5"/>
    <dbReference type="Gramene" id="KVH92105">
        <property type="protein sequence ID" value="KVH92105"/>
        <property type="gene ID" value="Ccrd_005868"/>
    </dbReference>
    <dbReference type="OMA" id="IPIKWKG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="93"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="10">
        <location>
            <begin position="593"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH92105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="697" mass="75580" checksum="5F52E599AB396301" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK40</accession>
    <name>A0A103XK40_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_005764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004836">
        <property type="protein sequence ID" value="KVH92190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XK40"/>
    <dbReference type="Gramene" id="KVH92190">
        <property type="protein sequence ID" value="KVH92190"/>
        <property type="gene ID" value="Ccrd_005764"/>
    </dbReference>
    <dbReference type="OMA" id="KYRQFAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098653">
        <property type="term" value="P:centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009556">
        <property type="term" value="P:microsporogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF1">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="9">
        <location>
            <begin position="939"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH92190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1330" mass="147406" checksum="282CD75C987A46AE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKN7</accession>
    <name>A0A103XKN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein strawberry notch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_005486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SBNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XKN7"/>
    <dbReference type="Gramene" id="KVH92458">
        <property type="protein sequence ID" value="KVH92458"/>
        <property type="gene ID" value="Ccrd_005486"/>
    </dbReference>
    <dbReference type="OMA" id="QPPEPIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057024">
        <property type="entry name" value="Znr_FGT1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057025">
        <property type="entry name" value="Znr_FGT1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF13">
        <property type="entry name" value="PROTEIN FORGETTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23547">
        <property type="entry name" value="Zn_ribbon_FGT1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23548">
        <property type="entry name" value="Zn_ribbon_FGT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="702"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH92458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145777" checksum="B644E0218021D280" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMN3</accession>
    <name>A0A103XMN3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine beta-synthase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_004383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004747">
        <property type="protein sequence ID" value="KVH93559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMN3"/>
    <dbReference type="STRING" id="59895.A0A103XMN3"/>
    <dbReference type="Gramene" id="KVH93559">
        <property type="protein sequence ID" value="KVH93559"/>
        <property type="gene ID" value="Ccrd_004383"/>
    </dbReference>
    <dbReference type="OMA" id="FSHRMAD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009569">
        <property type="term" value="C:chloroplast starch grain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009859">
        <property type="term" value="P:pollen hydration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH93559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="47037" checksum="3DB63F49AE043CDF" modified="2016-04-13" version="1">MVPRFPASGTPSISGDSMEIDSDPFHHSQHYGWVSSILQILDTLQEVVPKRLEADVELSRHRISVFLSTHTAYELLPESGKVVALDVTLPVKQAFHILYEQGISVAPLWDHGIGRFVGILSPLDFILILRELGNHGSNLTEEELETHAISAWKAGKLQLTRKFDGNGSLNPRHLIDVLFGGDGKKMMGGKEGLGWVIVVMVELEDGWGAGPHDSLKDVALKLLQNKVATVPVISWDGSIPQLLHLASLTGVLKCICRHFKHSPTSLPILQQPICSIPLGTWVPKIGESNGHPFAMLRANASLSDALSLLVQAEVSAVPIVDDNDSLLDIYCRSDITALAKDRAYAQIHLNELSIHQVGNKALQLTQEASATYGFFNGQRCHMCLRSDPLHKVMDRLAIPGVRRLVIVEAGSKRVEGIISLTDLFRFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XNE3</accession>
    <name>A0A103XNE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L24e, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004587">
        <property type="protein sequence ID" value="KVH93885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XNE3"/>
    <dbReference type="STRING" id="59895.A0A103XNE3"/>
    <dbReference type="Gramene" id="KVH93885">
        <property type="protein sequence ID" value="KVH93885"/>
        <property type="gene ID" value="Ccrd_004052"/>
    </dbReference>
    <dbReference type="OMA" id="IETCHLC"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="170" mass="20205" checksum="2A9A8A7EA3D61306" modified="2016-04-13" version="1">MRLEKCWFCSSTIYPGHGIQFVRNDAKIFRFCRSKCHKNFKMKRNPRKVKWTKAYRRLHGKDMTQDSTFEFERKRNRPERYDRNLTENTLKAIKTIDKVRSRRGEMHHKNRMKGKAAKERREARKEHDQQLHMVVAPGATLGSLAKDATATPAKAKVKVQQESEENRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP36</accession>
    <name>A0A103XP36_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_003696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MS5 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004560">
        <property type="protein sequence ID" value="KVH94235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP36"/>
    <dbReference type="STRING" id="59895.A0A103XP36"/>
    <dbReference type="Gramene" id="KVH94235">
        <property type="protein sequence ID" value="KVH94235"/>
        <property type="gene ID" value="Ccrd_003696"/>
    </dbReference>
    <dbReference type="OMA" id="MLMNEWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044961">
        <property type="entry name" value="MS5/SDI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326">
        <property type="entry name" value="PROTEIN POLLENLESS 3-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326:SF14">
        <property type="entry name" value="PROTEIN SULFUR DEFICIENCY-INDUCED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH94235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="260" mass="29767" checksum="A309CD9DEC7BA9D1" modified="2016-04-13" version="1">MEVNSRKKEDDEFHIIHKVPYGDGPYLVERDQEGAIVWFWKAINAGDRVESALKDMAVVMKQLDRTEEAIEAKCGKVDEQIGLLKQKLRMIYRGEAFNGRPTKTARSHGKKFQVSVKQETSRILGNLGWAYMQKSNFMAAEVVYKKAQMIDPDANKACNLGLCLMKQARYDEARSVLRNVVNRELPGAEDIRTINRARELLTEAEMWRPPAGLLPDLPGLDLDDDFVNGLEKLMNVWAPNRSKRLPIFEQIENFRDQLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQE0</accession>
    <name>A0A103XQE0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004514">
        <property type="protein sequence ID" value="KVH94859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQE0"/>
    <dbReference type="Gramene" id="KVH94859">
        <property type="protein sequence ID" value="KVH94859"/>
        <property type="gene ID" value="Ccrd_003083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="116" mass="12815" checksum="F17530325807D61E" modified="2016-04-13" version="1">MGKIAQVDGMDRVLISAAFLGNSVKLSVRSETNNIINMTGIDFSWFSQSINISHGGRDPSVITNPQAEVSYDNMNSPISSFCSLLGFEKAKEYQLDNQSFAKESDLFGSSIQDYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQK7</accession>
    <name>A0A103XQK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UVR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004483">
        <property type="protein sequence ID" value="KVH94964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQK7"/>
    <dbReference type="STRING" id="59895.A0A103XQK7"/>
    <dbReference type="Gramene" id="KVH94964">
        <property type="protein sequence ID" value="KVH94964"/>
        <property type="gene ID" value="Ccrd_002967"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34957">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34957:SF1">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="198"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="35450" checksum="D5AA1C19FB12E9E8" modified="2016-04-13" version="1">MGVFTLGCRCSGSEWSVKQLKGDLEASADSSYTLQRKLVHVAFSSDSSGGVQSTFSYVLPDSAVFQGSWCNKDLSSMPCSSISSFREKNKLSLQSRKQYNLVAICKPKQEMDVKLLSGCFNRPKRIPISFRRRSSCSLTPCQAKREDSEGTLSSESIVLDEQTLEQELQIAIQEENYAQAAKIRDSLKLLHEDSKTAVLAANSRFYNSFRNGDLAAMQELWSKSENVCVVHPGVSGISGYELVMGSWEFVWADYEFPLSIEVKDVQVHVRGDMGYATCVEMVRTAGKSWGRQFATNVFEKIDGRWFICVHHASHVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRQ0</accession>
    <name>A0A103XRQ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_002270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004380">
        <property type="protein sequence ID" value="KVH95663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRQ0"/>
    <dbReference type="STRING" id="59895.A0A103XRQ0"/>
    <dbReference type="Gramene" id="KVH95663">
        <property type="protein sequence ID" value="KVH95663"/>
        <property type="gene ID" value="Ccrd_002270"/>
    </dbReference>
    <dbReference type="OMA" id="NINPYMA"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052272">
        <property type="entry name" value="GT106_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31933">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31933:SF1">
        <property type="entry name" value="PROTEIN PECTIC ARABINOGALACTAN SYNTHESIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH95663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="552" mass="63111" checksum="AE39D6DF4AC80F08" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS31</accession>
    <name>A0A103XS31_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Photosystem I PsaA/PsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004375">
        <property type="protein sequence ID" value="KVH95858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS31"/>
    <dbReference type="STRING" id="59895.A0A103XS31"/>
    <dbReference type="Gramene" id="KVH95858">
        <property type="protein sequence ID" value="KVH95858"/>
        <property type="gene ID" value="Ccrd_002077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1130.10">
        <property type="entry name" value="Photosystem I PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001280">
        <property type="entry name" value="PSI_PsaA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036408">
        <property type="entry name" value="PSI_PsaA/B_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN, OMPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128:SF19">
        <property type="entry name" value="PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00223">
        <property type="entry name" value="PsaA_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81558">
        <property type="entry name" value="Photosystem I subunits PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10207" checksum="5FBFF96C96C16E87" modified="2016-04-13" version="1">MGGEGLAWYCAMNASNCAVNAFRANSHLVWATGFMFLISWRGYWQDLIETLAWAHERTPLANLIRWRDKPVALSIVQARLKRSTFSGCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS89</accession>
    <name>A0A103XS89_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004368">
        <property type="protein sequence ID" value="KVH95948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS89"/>
    <dbReference type="Gramene" id="KVH95948">
        <property type="protein sequence ID" value="KVH95948"/>
        <property type="gene ID" value="Ccrd_001970"/>
    </dbReference>
    <dbReference type="OMA" id="EVFPSHD"/>
    <dbReference type="OrthoDB" id="1692623at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000018">
        <property type="entry name" value="agamous-like MADS-box protein AGL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF387">
        <property type="entry name" value="AGAMOUS-LIKE MADS-BOX PROTEIN AGL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="249" mass="27567" checksum="157611642C988AD7" modified="2016-04-13" version="1">MPRSKVKLEYITDEYARKTSFMKRKTSVMKKLNELCTLCGVDACAIMYSEYDPEVEVWPSNVGAQFVLDQFMMMPEVEQSKKMVNQDSYIRKRISKAKEQLDKHMKENREKKIGIVISECLSGEASVVSLTLMDLKDMVFLIDHYVSEIDARLEFLKGGGPPPPPQLVQPQANVGGSSTDNHMVEGGVPADGYVPVVENAGALDGIIPNTEWFTDWVDGLGFGQGDHMTSNSPAADPNPPWSSPSSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTI4</accession>
    <name>A0A103XTI4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpene synthase, metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004265">
        <property type="protein sequence ID" value="KVH96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTI4"/>
    <dbReference type="Gramene" id="KVH96608">
        <property type="protein sequence ID" value="KVH96608"/>
        <property type="gene ID" value="Ccrd_001303"/>
    </dbReference>
    <dbReference type="OMA" id="IAYHFND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF137">
        <property type="entry name" value="TERPENE SYNTHASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="279"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="50097" checksum="EC44E54327694D87" modified="2016-04-13" version="1">MSSPFYINSLSKTSGAFSSNPQHPWRLVSSSPCKTSRVCRFKISLPVLPLATIAMPLTHCKPKAISSEVDVGSRMDELHEKTTRALMTASNPRMTMKLFDTIQRLGIGYSFDEEFIHKLIDPVEGQLDDDLYTVALRFRLQRTNGLHTNSDVFGPFLDANGKFKESSINDTEALLSLYEASYLGANGEDVLSQAKEFTTIHLKKSVSQLTPKLRKRVLHSLELPRHLRMDRLESRRYIEEYENESDHIPILLELAKLEYNQVQSLHQMELAEITRWWRHLGLVTKLTFARDRPLECFLWSVGLLPESKYSANRIELAKTISILLVIDDIFDTYGSYDDLVLFTKAIQRWDLKEMEQLPEYMKICYMALYNTTNEICYEVLKEHGLSVLPFLRKTWINMVEAFMVEVEWKKGRTAPNLKDYIENGVTTAGTYMALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW23</accession>
    <name>A0A103XW23_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families). Interacts with SIC/RON3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW23"/>
    <dbReference type="STRING" id="59895.A0A103XW23"/>
    <dbReference type="Gramene" id="KVH97958">
        <property type="protein sequence ID" value="KVH97958"/>
        <property type="gene ID" value="Ccrd_023824"/>
    </dbReference>
    <dbReference type="OMA" id="LSHHDTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000569">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000609">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="490" mass="54846" checksum="779255DCCBEABAEC" modified="2016-04-13" version="1">MNGGDGGDVAAAPAGPPPPLDWKFSQVFGERTAGEEVQEVDIISAIEFDKSGDHLATGDRGGRVVLFERTDKKENGGNRKDLEKTDYSISRHPEFRYKTEFQSHEPEFDYLKSLEIEEKINKIRWCQTANGALFLLSTNDKTIKFWKVQEKKIKKIADMSMEPSKATGNGNVASPSVTSSTPKPQLANGGYTDKSYTSLSNELLFPPRGISSLRLPVVTSNETNLVARCRRVYAHAHDYHINSISNNSDGETFISADDLRINLWNLEISNQSFNIVDVKPANMEDLTEVITSAEFHPTHCHTLAYSSSKGSIRLIDLRQSALCDKHSKLFEEQEAPGTRSFFTEIIASISDIKFGRDGRYILSRDYMTLKLWDINMDSGPVSTFQVHEYLRPKLCDLYENDSIFDKFECCLSGDGQRVSTGSYRRQVQTPLRPRSLSSITRAVRRGGDSPGVDANGNSFDFTTKLLHLAWHPTENSIACAAANSLYMYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXC8</accession>
    <name>A0A103XXC8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-repeat-containing domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003779">
        <property type="protein sequence ID" value="KVH98631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXC8"/>
    <dbReference type="STRING" id="59895.A0A103XXC8"/>
    <dbReference type="Gramene" id="KVH98631">
        <property type="protein sequence ID" value="KVH98631"/>
        <property type="gene ID" value="Ccrd_023144"/>
    </dbReference>
    <dbReference type="OMA" id="CLQRICG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47467">
        <property type="entry name" value="OS01G0867200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47467:SF1">
        <property type="entry name" value="WD40 REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH98631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="338" mass="37415" checksum="C1D7156109A77429" modified="2016-04-13" version="1">MLEARSLKKVEVPSTLIEYPSPANLHSNRLALHVSEDGTSCWVYVASGCQIYRILVSLKDSLVNEGKDSLLIPEHTQVVDSAIVNRCPHRSEIQTVVLNETESNDRLILGSVDSYGHLIVSRLDSDSKDVERLTFSVSPRDFGVGEGGWAGLCFSPSQWSTTAVAHSFGKSIDVYDQDLHLRTFRTSMLAVTEGCQLSIWDLRIKENGGCVHRICGSVGDIWYAVSSSSNGYIAVGGADRTMTVYDPRRWSAISRWVNCSKYEITGISFSSIDPNYAYIQGVDYEVFCGQWKESKKAFSFRGDSNWLGFSKCANRDVLGGWCDSGSIFVADVVEGKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXD2</accession>
    <name>A0A103XXD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003783">
        <property type="protein sequence ID" value="KVH98612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XXD2"/>
    <dbReference type="Gramene" id="KVH98612">
        <property type="protein sequence ID" value="KVH98612"/>
        <property type="gene ID" value="Ccrd_023161"/>
    </dbReference>
    <dbReference type="OMA" id="DFANQDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1891" mass="207536" checksum="1A6A1EEB35D79B02" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYL8</accession>
    <name>A0A103XYL8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003622">
        <property type="protein sequence ID" value="KVH99302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYL8"/>
    <dbReference type="STRING" id="59895.A0A103XYL8"/>
    <dbReference type="Gramene" id="KVH99302">
        <property type="protein sequence ID" value="KVH99302"/>
        <property type="gene ID" value="Ccrd_022461"/>
    </dbReference>
    <dbReference type="OMA" id="CYEATHH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.50:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10700">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.50">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667:SF3">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142535">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="35594" checksum="6EB248BA473327D6" modified="2016-04-13" version="1">MSSCLSGRLIAARSLAFRKTSFRSHIRRLMVTLVVATTIDPASIGPASALLAMPGWHPGPFLQDMASFVNKGVRLLKHDNSIVREDHLDKRWETATGEVVDEVIFLSRHTAASNRPALTIHPIGVPHLREDEVPAAGGKPGWAAPPNARMGPWLRLLKVTLEATHHGPVIDSPTMFVEIGSTEEYWKRQDAAQAIALLVWKGLGLDGGIPVGDWSRHNGKKKILLGVGGGHYVPRHMDIVLKDDVWVGHLLSGYSLPMEDNGDAGVGGTWREAIKVAYEVTKASFPGGEILAHLDQKSFKSWQKNAILSFLKEQNINVGKPTNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZC8</accession>
    <name>A0A103XZC8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_022086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003422">
        <property type="protein sequence ID" value="KVH99683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZC8"/>
    <dbReference type="STRING" id="59895.A0A103XZC8"/>
    <dbReference type="Gramene" id="KVH99683">
        <property type="protein sequence ID" value="KVH99683"/>
        <property type="gene ID" value="Ccrd_022086"/>
    </dbReference>
    <dbReference type="OMA" id="DIMWATD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000013">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000019">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119239" description="argininosuccinate lyase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="10">
        <location>
            <begin position="107"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="11">
        <location>
            <begin position="465"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH99683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="566" mass="63103" checksum="720BD880B081B7C4" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0E7</accession>
    <name>A0A103Y0E7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase, beta-propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003396">
        <property type="protein sequence ID" value="KVI00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0E7"/>
    <dbReference type="STRING" id="59895.A0A103Y0E7"/>
    <dbReference type="Gramene" id="KVI00221">
        <property type="protein sequence ID" value="KVI00221"/>
        <property type="gene ID" value="Ccrd_021548"/>
    </dbReference>
    <dbReference type="OMA" id="VEHVTNM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000007">
        <property type="entry name" value="F-box/kelch-repeat protein SKIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052439">
        <property type="entry name" value="F-box/Kelch-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122">
        <property type="entry name" value="GALACTOSE OXIDASE/KELCH REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="42309" checksum="7C29627EA242D22B" modified="2016-04-13" version="1">MSEQEELEEGSGVERMKGKGGDFDGKLTYSSNDSLLPGLYDDVALICLAWACRFDYASLSCLNVRFNLLMKSGYLYELRKQLGIIEHWVYMVCDPRGWEAFDPTSKKWMRLPKIPCDECFNHADKESLAVGSELLVFGRELFEFAIWKYSLIHRNWVKCEGMSHPRCLFGSGSFGMVAIVAGGSDQNGNILKSAELYDSSTGRWEMLPNMHSPRRLCSGFFMDGKFYVIGGMTSPNDSLTCGEELDLKTKKWRKIDGMYPNINRAAQAPPLVAVVANQLYAVEYLSNMVKKYDKEKNSWDVLGRLPVRADSSNGWGLAFRACGEELLVVGGQRGPEGEAIVLNSWSPKSGVKNGVLDWKVIGVKEHAGVFVYNCAVMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2A1</accession>
    <name>A0A103Y2A1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">aminocyclopropanecarboxylate oxidase</fullName>
            <ecNumber evidence="8">1.14.17.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = ethene + L-dehydroascorbate + hydrogen cyanide + CO2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:23640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18153"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.14.17.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.4" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2A1"/>
    <dbReference type="STRING" id="59895.A0A103Y2A1"/>
    <dbReference type="Gramene" id="KVI01209">
        <property type="protein sequence ID" value="KVI01209"/>
        <property type="gene ID" value="Ccrd_020534"/>
    </dbReference>
    <dbReference type="OMA" id="YPQCPHP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009815">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071732">
        <property type="term" value="P:cellular response to nitric oxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000010">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0266">Ethylene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="301" mass="34603" checksum="C50E67A3A4938DFB" modified="2016-04-13" version="1">MSIPMIDFSKLDGEERSKTMALLHHACEKWGFFQIENHGVDKELMDKVKQLVNQHYQENMEKNFYNSEIAKKFEDKSNTTDIDWESTFFIWHRPENKINVYTNLSEELRKAMDEYIDQLIKVAEKLSELMCENLGLNKEYIKEAFSGGKGPSVGTKVAKYPKCPRPELVRGLREHTDAGGIILLLQDDQVPGLEFFKDGKWVNIPPSKNNTIFVNTGDQVEVLSNGNYKSTVHRVMTDKDGSRLSIATFYNPAGDAVISPARELLYPNRYTFQDYLKLYSSTKFADKGPRFESMKKMVNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2B4</accession>
    <name>A0A103Y2B4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_020502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2B4"/>
    <dbReference type="STRING" id="59895.A0A103Y2B4"/>
    <dbReference type="Gramene" id="KVI01211">
        <property type="protein sequence ID" value="KVI01211"/>
        <property type="gene ID" value="Ccrd_020502"/>
    </dbReference>
    <dbReference type="OMA" id="TFMTRTD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="86"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI01211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="37245" checksum="4E44B2E00BA9F813" modified="2016-04-13" version="1">MESEDGDSNRVDSSDLSSTSSTVSSIFGSSDVDFSSSFSITSSSSGEILAAAVVPLKLMAEVQPAEGGGGGTRRLKKCVGRSKGVTWGFKSVIGRRKEMEDAVAVVPGFMSGTCDHVGGCTTPGSRTSLEISPIHFFGVYDGHGGSQVAKFCAERMHEVIAEEWDQEAADGFKWQQRWEAVMSSSFERADNEVLSEAAAPEIVGSTAVAVVLSGCQIIVSNCGDSRAVLCRGMETIPLTVDQKPDRADELLRIEEQDGKVINWNGARDECLILASDGLWDVMSNNEVGEVARRVLRRRRRYAIDNESPAAQILADSLIEIAVGRNSSDNISVIVVDLKSKKKQQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2I4</accession>
    <name>A0A103Y2I4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Sucrose-phosphate synthase</fullName>
            <ecNumber evidence="4 9">2.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_020397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = sucrose 6(F)-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57723"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose biosynthesis; sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.14" evidence="4 9"/>
    <dbReference type="EMBL" id="LEKV01003119">
        <property type="protein sequence ID" value="KVI01329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2I4"/>
    <dbReference type="STRING" id="59895.A0A103Y2I4"/>
    <dbReference type="Gramene" id="KVI01329">
        <property type="protein sequence ID" value="KVI01329"/>
        <property type="gene ID" value="Ccrd_020397"/>
    </dbReference>
    <dbReference type="OMA" id="CYTFTVK"/>
    <dbReference type="UniPathway" id="UPA00371">
        <property type="reaction ID" value="UER00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046524">
        <property type="term" value="F:sucrose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000077">
        <property type="entry name" value="Sucrose-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044161">
        <property type="entry name" value="SPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012819">
        <property type="entry name" value="SPS_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth_GT-B1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02468">
        <property type="entry name" value="sucrsPsyn_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039:SF2">
        <property type="entry name" value="SUCROSE-PHOSPHATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039">
        <property type="entry name" value="SUCROSE-PHOSPHATE SYNTHASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="GT-B_Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose synthase first GT-B" evidence="11">
        <location>
            <begin position="167"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="647"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI01329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112920" checksum="230BC6C21F4FAEAB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2J7</accession>
    <name>A0A103Y2J7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARP2/3 complex, 21kDa subunit (p21-Arc)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003119">
        <property type="protein sequence ID" value="KVI01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2J7"/>
    <dbReference type="STRING" id="59895.A0A103Y2J7"/>
    <dbReference type="Gramene" id="KVI01330">
        <property type="protein sequence ID" value="KVI01330"/>
        <property type="gene ID" value="Ccrd_020394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="213" mass="24714" checksum="C22055D32B1875A3" modified="2016-04-13" version="1">MVINGGRWTEVEDESNFQFWPLNVIVKSVQFFRRTVTASSSDQKKSILSSSMKSIIPRANVFFKHFDLKSPADRILVYLTFYINLALKRLEGCRTVTEGTNAIKNLGFEHVHVPGESEVLRDYFKQIREETSRRLLNVAYRGNGTPNKWWLAFAKHYVPHLYSGEPFGFVEDQELMWARSLRDRGVQMLRITIVDILVIPRQNGNNFSNWPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3C3</accession>
    <name>A0A103Y3C3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calmodulin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant ACBP60 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002685">
        <property type="protein sequence ID" value="KVI01752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3C3"/>
    <dbReference type="STRING" id="59895.A0A103Y3C3"/>
    <dbReference type="Gramene" id="KVI01752">
        <property type="protein sequence ID" value="KVI01752"/>
        <property type="gene ID" value="Ccrd_019967"/>
    </dbReference>
    <dbReference type="OMA" id="NQFRVEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046829">
        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF65">
        <property type="entry name" value="CAM-BINDING PROTEIN 60-LIKE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="9">
        <location>
            <begin position="198"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein C-terminal" evidence="10">
        <location>
            <begin position="267"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI01752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="472" mass="52705" checksum="A07AA26B14BA4AED" modified="2016-04-13" version="1">MGARRSSAFMSEILLYITKVRFPSTRSSFNVLEPCRKTSLQLRILAKLPDTFFTGSQIESKDKTAVKLVLFDINSNKVVSSGPLSSLKIEIVPLDGDFIADNDEDWSEKDFNSKVIHARDGRRPLITGDLVVTLENGVTDLGDLCFTDNSSWRRSRKFMVGARAKGTAGVRIREATSQAFVVKDHRGESYKKHHPPSLGDEIWRLEKIAKDGVSHKRLASHGICTVKDFLQVYATNESSLRNLLGGSSNKTWETVIKHAKDCVLDEKLYMYPCAAQGIGLLLDSVLKVVGATFDGLDYLPLDKLSVLQMPMVEALKQQVYKNLEGRVPMDDPSVFGVLVPMSNLKTASLGLQDVNIPHLLQDEVDLHICGVGTVQPDHDPPSIRYFSSPGLKNSFIMREFNTEEEDIGIEFGASLWEGYEDPNNHQTLDFGICFGSPRARWCKIRAAVKWGSVRRDVAAKRTAELHSYLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3P6</accession>
    <name>A0A103Y3P6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3P6"/>
    <dbReference type="Gramene" id="KVI01964">
        <property type="protein sequence ID" value="KVI01964"/>
        <property type="gene ID" value="Ccrd_019747"/>
    </dbReference>
    <dbReference type="OMA" id="PGQWFQS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054:SF83">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ternary complex factor MIP1 leucine-zipper" evidence="3">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="291"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48217" checksum="2534B1E9122305C4" modified="2016-04-13" version="1">MEFNSSKHKRAKSDLARKRIHEDKNPILNAPQPPKTVTEQVKICEEPHQRRVESIEVKTSLKEESSKDLIKEISLLEFEVKHLEKYLLSLYRKTFQKKEPSLSATDTKSILKEQQSSLVNSSSFMPARASTDNPPKDFGPILESQPMEDSYVNRSHSSLSYRTPPIYMAVNQAVESYHSLPLGMLEHAKDDCSSVSLAEHLGGCIPDNIPMSANRLSEEMIKCISSIYGQIADPPLFNHDFPSSPLSFPSPPSDSSPRDQFSMWSPHCEGSMEFGESYFTTVEVQEQIDPRTLKHEEKLAFWINIHNALVMHAAYNIGGHNISVGDIQNTILGCRPPHPGQWFQSLLFPSPKYKSRDVRKAYAMKHSQPLVYFALCSGSLSDPMVHKSEPSPKSFKQIRKGKSTKKIEWVAHDFGFRYLLSPDLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4T7</accession>
    <name>A0A103Y4T7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_019180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4T7"/>
    <dbReference type="STRING" id="59895.A0A103Y4T7"/>
    <dbReference type="Gramene" id="KVI02527">
        <property type="protein sequence ID" value="KVI02527"/>
        <property type="gene ID" value="Ccrd_019180"/>
    </dbReference>
    <dbReference type="OMA" id="FQNLKCC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000045">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="722" mass="80448" checksum="EFD1BDC981EE8071" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5J1</accession>
    <name>A0A103Y5J1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_018786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002613">
        <property type="protein sequence ID" value="KVI02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5J1"/>
    <dbReference type="STRING" id="59895.A0A103Y5J1"/>
    <dbReference type="Gramene" id="KVI02918">
        <property type="protein sequence ID" value="KVI02918"/>
        <property type="gene ID" value="Ccrd_018786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1277">
        <property type="entry name" value="HOMEODOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="17001" checksum="6692A411949D5441" modified="2016-04-13" version="1">MVKSISFDKNGVKKGAWSEEEDDKLRAYIQRYGHWNWGLLPQFAGSLESPSCSSGTELSACWMSGSDYTVSSEVALQTSDYESAGDFWSEPFLPDITSSIDNMLSHSDLIEGYMSHDQSSCQDVTMSDEFSWSTFDPYFQYNNEPVDWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6W0</accession>
    <name>A0A103Y6W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallothionein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Metallothioneins have a high content of cysteine residues that bind various heavy metals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallothionein superfamily. Type 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002338">
        <property type="protein sequence ID" value="KVI03607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6W0"/>
    <dbReference type="Gramene" id="KVI03607">
        <property type="protein sequence ID" value="KVI03607"/>
        <property type="gene ID" value="Ccrd_018094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000347">
        <property type="entry name" value="Metalthion_15p"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01439">
        <property type="entry name" value="Metallothio_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="7809" checksum="D844E5024612F9CA" modified="2016-04-13" version="1">MSCSSGKCSCGSSCSCGSSCNCNSADIERSTTTTIIVDDMPREQRPASLSRVQTDASAVETASVILATVKQRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y731</accession>
    <name>A0A103Y731_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y731"/>
    <dbReference type="STRING" id="59895.A0A103Y731"/>
    <dbReference type="Gramene" id="KVI03728">
        <property type="protein sequence ID" value="KVI03728"/>
        <property type="gene ID" value="Ccrd_017975"/>
    </dbReference>
    <dbReference type="OMA" id="RIYANND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47560">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47560:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57952" checksum="1C6E0FF49A037193" modified="2016-04-13" version="1">MYQETSSKYSNLKKRAKFALGKSVNSSRDKVKTLDFKKKGFGGNDRRGQSTRVKTDNIVSNVEDEFFKRSGRSDNMKSKNDRFRGDRSKRVVTDNGSSVDGNLHKKDFRGRGLKSNYRGRNVGEVQGNESNGFAGRDFDRKRKRIYANNDSNGESKFHNKAKVPVGKGLSRARWNAGKEDLVKGNETARRGSRASASLSQNRHSNGRETPDGGDRRKNTEHRENRSVLLRNNGEGKHETSKQLRLKQTGPAEDSEFGKKKFQNKKNLVDDSVAMFDRPRRKRRIMRIEYPNDTANKRFDDSIPAIDNTTEQKEDSDNEENTELSKNAQFRAIQPSPSIISFVEENILGRRREIEFRKAGYNIELSSPLDNIPFSTSSERERIEESTINFFNLGSKLCLVDLPGYGFAYAKEEVKESWEELVKEYVSTREGLKRVCLLIDTKWGMKPRDHELVDLMEKIDLTDTIHLIVQSLKTKKSAVQPLMMVSSKTGAGIRSLRTVLSNISRFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7N2</accession>
    <name>A0A103Y7N2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2 8">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2 8"/>
    <dbReference type="EMBL" id="LEKV01002314">
        <property type="protein sequence ID" value="KVI04028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7N2"/>
    <dbReference type="STRING" id="59895.A0A103Y7N2"/>
    <dbReference type="Gramene" id="KVI04028">
        <property type="protein sequence ID" value="KVI04028"/>
        <property type="gene ID" value="Ccrd_017664"/>
    </dbReference>
    <dbReference type="OMA" id="WEVEQVG"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:cytokinin riboside 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000005">
        <property type="entry name" value="CASP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF14">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="218" mass="23688" checksum="3F708787172B5C9E" modified="2016-04-13" version="1">MENENKSRFKRVCVFCGSSSGKRDVYGDAAIELAQELVAKKLDLVYGGGSIGLMGLVSQAVHCGGGHVLGIIPRALMGKEKTGESIGEVKAVADMHERKAEMARNSDCFIALPGGYGTLEELLEVITWAQLGIHDKPVGLLNVDGYYNYLLTFIDKAVDDGFIKPSQRHIFVSAPNAKELVQKLEEYIPVKDGVIPQVKWEVEQVGFNALHASAEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7Z3</accession>
    <name>A0A103Y7Z3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/POZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_017490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002299">
        <property type="protein sequence ID" value="KVI04194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7Z3"/>
    <dbReference type="Gramene" id="KVI04194">
        <property type="protein sequence ID" value="KVI04194"/>
        <property type="gene ID" value="Ccrd_017490"/>
    </dbReference>
    <dbReference type="OMA" id="LDEMPQW"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51649">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NPH3" evidence="5">
        <location>
            <begin position="251"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI04194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="602" mass="68036" checksum="70B345007B8C7086" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8W0</accession>
    <name>A0A103Y8W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Pyruvate kinase</fullName>
            <ecNumber evidence="6 20">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ccrd_017010</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 20"/>
    <dbReference type="EMBL" id="LEKV01001941">
        <property type="protein sequence ID" value="KVI04671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8W0"/>
    <dbReference type="STRING" id="59895.A0A103Y8W0"/>
    <dbReference type="Gramene" id="KVI04671">
        <property type="protein sequence ID" value="KVI04671"/>
        <property type="gene ID" value="Ccrd_017010"/>
    </dbReference>
    <dbReference type="OMA" id="SVGIWSK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000003">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000008">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="17 20" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 20 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-0630">Potassium</keyword>
    <keyword evidence="18 23" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="21">
        <location>
            <begin position="108"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="22">
        <location>
            <begin position="464"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KVI04671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="578" mass="63426" checksum="0AD13FB554EBEA87" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9G0</accession>
    <name>A0A103Y9G0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001893">
        <property type="protein sequence ID" value="KVI04959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9G0"/>
    <dbReference type="Gramene" id="KVI04959">
        <property type="protein sequence ID" value="KVI04959"/>
        <property type="gene ID" value="Ccrd_016702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="8123" checksum="6818AA6734712939" modified="2016-04-13" version="1">MEIKGKSTKKHKTMIPPRRGKIKKRIFKKILNMTLCLTRIQIARKKQRESIMTSWWRKLNDDLIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA50</accession>
    <name>A0A103YA50_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001878">
        <property type="protein sequence ID" value="KVI05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA50"/>
    <dbReference type="STRING" id="59895.A0A103YA50"/>
    <dbReference type="Gramene" id="KVI05332">
        <property type="protein sequence ID" value="KVI05332"/>
        <property type="gene ID" value="Ccrd_016335"/>
    </dbReference>
    <dbReference type="OMA" id="WISVIEE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000070">
        <property type="entry name" value="transcription factor bHLH30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045847">
        <property type="entry name" value="AIG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844:SF24">
        <property type="entry name" value="MYC-TYPE, BASIC HELIX-LOOP-HELIX (BHLH) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="33186" checksum="D548CFDA8A0B614A" modified="2016-04-13" version="1">MHHHRPSSWTTLSPPLHFNHLLPCPTGDHPFLLPPPPSSNSPPSSLSSHGGFFKRVVDGLQFAYEGSTSTSTSTTPPSTHHHLGFQVVQHGSDPFGIQPETGNKIMTAQEMVDAKAVAASKSHSEAERRRRERINNHLTKLRSLLPNTTKTDKASLLAEVIQHVKELKHQTSIIAEQVPVPTEINELTIDNTSDEEGRFVIRASLCCEDRSDLLPDLIKTLKMLRLRTLKAEITTLGRRVKNVLFVTGEEDHYISNGDTQMVNQWISVIEEALKAVVEKTDDGDDSSFGSVKRQRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAU7</accession>
    <name>A0A103YAU7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxal phosphate-dependent transferase, major region, subdomain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001862">
        <property type="protein sequence ID" value="KVI05709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAU7"/>
    <dbReference type="STRING" id="59895.A0A103YAU7"/>
    <dbReference type="Gramene" id="KVI05709">
        <property type="protein sequence ID" value="KVI05709"/>
        <property type="gene ID" value="Ccrd_015906"/>
    </dbReference>
    <dbReference type="OMA" id="CTLNNTH"/>
    <dbReference type="OrthoDB" id="2018302at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF60">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="368" mass="41866" checksum="F7143042A6253B41" modified="2016-04-13" version="1">MGRNAQEQVILQQQSKMDEIEIAKSMITSLPTSPNHNIGSRPTSMVMKKAHTVFPAHLVAEAISTLHGLDLRWSGPITPQEMEYVKQYIFAKYPEYCNGLIVEEGDKIDLYNICSNDESSLEASIISDDKRKYSPRVITIKDSSSPSSFSPTYDLDGTQLEPSKLLEILNKKSSFQGNFMSIPEIQVRNKALQNCGLQEDEYLVLFTPTFKEAMVMIGESYPFFRGNYYMSIINEKEDSVREFVGTKDSKVVAAPESWLDLRIKGSQLSQYFRRKCKYSPKGLFAYPAYVNGTSYSMHWISEAHRNSWHVLLDATELEPTKERLTLALHRPDFVICTVDNTHAQPSKIICLLVRRKSFETTQPLVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBZ4</accession>
    <name>A0A103YBZ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001840">
        <property type="protein sequence ID" value="KVI06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBZ4"/>
    <dbReference type="Gramene" id="KVI06305">
        <property type="protein sequence ID" value="KVI06305"/>
        <property type="gene ID" value="Ccrd_015371"/>
    </dbReference>
    <dbReference type="OMA" id="KSCSRMC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000184">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF458">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="501"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="593" mass="66334" checksum="E4DE6079704A1EA5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCE3</accession>
    <name>A0A103YCE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor, K-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001809">
        <property type="protein sequence ID" value="KVI06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCE3"/>
    <dbReference type="STRING" id="59895.A0A103YCE3"/>
    <dbReference type="Gramene" id="KVI06521">
        <property type="protein sequence ID" value="KVI06521"/>
        <property type="gene ID" value="Ccrd_015131"/>
    </dbReference>
    <dbReference type="OMA" id="WATQYER"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51297">
        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="84"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="26520" checksum="DCED317A951817DF" modified="2016-04-13" version="1">MARGKIQIKKIENSTNRQVTYSKRRNGLFKKASELTVLCDAKVSIIMVSCTDKLHEYISPSITTKQFFDQYQKASGIDLWNSHYEKMQEEMRQLKEVNKNLRRQIRQRLGDCLEHVGFEELLDLEKESQEAVYIIRERKLKVIGNKLETSKKKVRSAQDVYKKLMHQFDIRGEDPQYGLIEDGEYETVYGYPPPQMGGGAPRILTLRLQPNHPNNLHAASDLTTYALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDA1</accession>
    <name>A0A103YDA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001534">
        <property type="protein sequence ID" value="KVI06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDA1"/>
    <dbReference type="STRING" id="59895.A0A103YDA1"/>
    <dbReference type="Gramene" id="KVI06966">
        <property type="protein sequence ID" value="KVI06966"/>
        <property type="gene ID" value="Ccrd_014673"/>
    </dbReference>
    <dbReference type="OMA" id="MYRDMND"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045000">
        <property type="entry name" value="TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898">
        <property type="entry name" value="TROPINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="267" mass="28278" checksum="82EF3414D6B7F8CA" modified="2016-04-13" version="1">MTTPAPAAESPGKSRWSLAGTTALVTGGSHGIGYAVVEELAALGAVVHTCSRNEAELNQVLEQWSAKGFAVTGSVCDVTSRSQRQHLLEEVSSHFGGNLHILVNNVGTCIYKPTTEFTAEDYSIMMATNFESSYHICQLSHPLLKASGSGSIVFISSVAGLVNALSGSLYGATKGAMNQLTRNLACEWANDNIRTNCVAPWVIKTPLVQPLVDNKELMDGVVFRTPLKRPGEPNEVSSLVAFLCLPAASYITGQTIAVDGGFTVNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YE91</accession>
    <name>A0A103YE91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001506">
        <property type="protein sequence ID" value="KVI07495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YE91"/>
    <dbReference type="STRING" id="59895.A0A103YE91"/>
    <dbReference type="Gramene" id="KVI07495">
        <property type="protein sequence ID" value="KVI07495"/>
        <property type="gene ID" value="Ccrd_014189"/>
    </dbReference>
    <dbReference type="OMA" id="FVFWVNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="208"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI07495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="43726" checksum="BE6CAFE127B5C78D" modified="2016-04-13" version="1">MVTVVPTPRNISPPPEPATLPKKLDAGALFVLKSRAPALLSLPFALALLGWESGVMVLVLAGVVTFYSYNLLSLVLEHYAYLGRRQLRFRDMAHDILGPGWGRYYVGPLQLGSCYGAVIACTLLGGQIYILVGKTKWKYAIIPFYCDIWKLYTHFSPNPIFPFLEAHQPCLPHLVLCLLCLYNCWCDLYRKLESRASQKLFFDGNRIVISNYFSVGISGYWAFGNQVQSSVLQNFMDNSNPLLPKWFLLMTNGFTVLQVAACTLVYLQPSNVVLERRFANPEKSQLSMRNFVPRLISRSLSVIIATTFAAMLPFFGDIMALFGAFGCIPLDFILPMIFYNLTFKPSKKGFVFWVNTVIGVVSTGLSLIGAVASVRQIILDARTYRLFADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YH54</accession>
    <name>A0A103YH54_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001075">
        <property type="protein sequence ID" value="KVI08993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YH54"/>
    <dbReference type="STRING" id="59895.A0A103YH54"/>
    <dbReference type="Gramene" id="KVI08993">
        <property type="protein sequence ID" value="KVI08993"/>
        <property type="gene ID" value="Ccrd_012616"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00711"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF64">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0438">Lignin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="102" mass="11763" checksum="217E3133D8AEABB3" modified="2016-04-13" version="1">MIDFREDPALLLFEQMINNVKFHGSFDFNFVDVDKDNYLNYHTRLIDLVKIGGVIGYDNTLLEWVFDAPLRKYVRLLPCGSSSSEQSLSVLQYPDLTSLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHF6</accession>
    <name>A0A103YHF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">monodehydroascorbate reductase (NADH)</fullName>
            <ecNumber evidence="8">1.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_012437</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.4" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHF6"/>
    <dbReference type="STRING" id="59895.A0A103YHF6"/>
    <dbReference type="Gramene" id="KVI09162">
        <property type="protein sequence ID" value="KVI09162"/>
        <property type="gene ID" value="Ccrd_012437"/>
    </dbReference>
    <dbReference type="OMA" id="EEHCMAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016656">
        <property type="term" value="F:monodehydroascorbate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048618">
        <property type="entry name" value="MDHAR3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21791">
        <property type="entry name" value="MDHAR3-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Monodehydroascorbate reductase 3-like C-terminal" evidence="11">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI09162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="53086" checksum="8148A80DCDF41E00" modified="2016-04-13" version="1">MGRAFVYVILGGGVAAGYAALEFTKKGVSHGELCIISEEPVAPYERPALSKGFLLPEAPARLPAFHTCVGANEERLTPKWYKEHGIELILGTRVKSADVRRKTLLTAAGETISYKFLIIATGARALKLEEFGVSGSDAENVCYLRDLADATRLVDVMQTSTGGNAVVIGGGYVGMECAASLVINKINVSMVFPEAHCMGRLFTPKIASHYEEFYKSKGVNFVKGTVLSSFAFNPEGKVNFSLFCSVSGVYLKDGSYLPADLVVVGIGIRPNTSLFEGQLTLEKGGIKVNGRLQSSNSSVYAVGDVASFPVKIFGEIRRLEHVDAARKSARHAVSAILEPEKTPEFDYLPFFYSRVFSLSWQFYGDNVGEAVYFGDFSGTSFGAYWVNKGHLVGSFLEGGSKEEYEAIAKVTRLKPVIEDLSELERQGLGFVVALSQKPGVSEAAKDMDVGGSSLVLEKAMYPWHAAAGVVVAASIAAFAYWYGRRRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI72</accession>
    <name>A0A103YI72_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_012056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001055">
        <property type="protein sequence ID" value="KVI09559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI72"/>
    <dbReference type="STRING" id="59895.A0A103YI72"/>
    <dbReference type="Gramene" id="KVI09559">
        <property type="protein sequence ID" value="KVI09559"/>
        <property type="gene ID" value="Ccrd_012056"/>
    </dbReference>
    <dbReference type="OMA" id="HATDTQS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119739" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="333"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI09559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="52318" checksum="1116975849AF3DDB" modified="2016-04-13" version="1">MIWPTIFLGLTLQVLLVFGARYPKNLHIWPMPESVEYGNKTIFLSKDFQLKTDGSKYADASGILKDGFTRLLDVITASNVIESNFSKVDESVLLQGVHVIVLSKDDELQYGVDESYELSIHPKGKPIYANIKAATVYGALHALQTFSQLCHFNLKRRKLEVSQIPWTITDRPRFAFRGLLIDTSRHYQPLPMIKKVIDSMAYAKLNVLHWHIVDTQSFPLEIPSYPKLWDGAYSLSERYTVAVAADIVKQVKEPLDISNAFTFKLIDGVLSDFSKIFKYKFVHLGGDEVDTSCWSSTPHIKEWLKQQGLNASQAYEYFVLNAQKIALLGSGVAERVVAAGLRCIVSNQDAWYLDHLSTTWQEFYTNEPLTNITNPTQQKLVIGGEVCMWGEHIDGSDIEQTIWPRAAAAAERLWTHPDKLAKTPKDVTSRLSHFRCLLNQRGVAAAPLDGPGRVAPIEPGSCYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ35</accession>
    <name>A0A103YJ35_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_011593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI10014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ35"/>
    <dbReference type="STRING" id="59895.A0A103YJ35"/>
    <dbReference type="Gramene" id="KVI10014">
        <property type="protein sequence ID" value="KVI10014"/>
        <property type="gene ID" value="Ccrd_011593"/>
    </dbReference>
    <dbReference type="OMA" id="ACYTCSH"/>
    <dbReference type="OrthoDB" id="667871at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057649">
        <property type="entry name" value="PUB62-63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33644:SF5">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33644">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23112">
        <property type="entry name" value="PUB62-63_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI10014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="439" mass="48309" checksum="1D229DD799DAF1BA" modified="2016-04-13" version="1">MASEEIALVLSHRSDNNHPQFLFQDESNLPFRCNPPQHHQQQRHTSGHHPAGHTTNNKTTRELTGFIEHQNRHYQPQATTDFRRSICDAAPAYHRGIQDWDIRNGRDSSSPSGDGSDSDDDGDGDDDEMDDGDGDGDDHVVGLVNSSNDIKNARKSNVSGHSSCVKNGNGKRTHLSSIGSSSEVMKEGIVIQNHQQTQLCQYQNAITVADPNGELYYSQYLRGAEGSGAGLKDMLVENGCGFSGRKDISNSGGSGESLRAILSDPLTGGLMDDAMILPCGHSFGSGGMQHVMRMKACYTCSHMVSEGSVTPNLSLRSAVLAFRREEELQTHRASKRRNRLEQDKSNYGDSTLMDQSKGRGVQFPFFVTDRVIIKGNKRTPPRFVGREAVVTTQCLNGWYVVKTLDNAESVKLQYRSLAKVEDARPLEVGSSKMTPPNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJI9</accession>
    <name>A0A103YJI9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_011376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001025">
        <property type="protein sequence ID" value="KVI10242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJI9"/>
    <dbReference type="STRING" id="59895.A0A103YJI9"/>
    <dbReference type="Gramene" id="KVI10242">
        <property type="protein sequence ID" value="KVI10242"/>
        <property type="gene ID" value="Ccrd_011376"/>
    </dbReference>
    <dbReference type="OMA" id="YNVTDER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF58">
        <property type="entry name" value="ALA-INTERACTING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI10242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38021" checksum="C117F53EB86C511C" modified="2016-04-13" version="1" fragment="single">NPFFLQILHLPSGNPKPSSKFCVLDPLIHPQSDLHLHLHLFVLIIIMSNPTTPMNANAPSSSSGGAGSPDSAPRRNSKRPKYSRFTQQELPACKPILTPKWVISAFMLVTIVFIPIGLASLFASRDVVEIIDRYDNACLTGSKSDKVQSIQSVSTNKTCFRSLTVRKRMKQPIYVYYQLDNFYQNHRRYVKSRSDSQLRNRGDENQTSDCKPENDVNGMAIVPCGLLSEQEDLIVWMRTAALPTFRKLYGKIEVDIEAGETINVIVGNHYNTYSFSGKKKLVLSTTSWLGGKNNFIGIAYLAVGGLCLLLATTFTLIYLVKPRHLGDPTYLSWNRNPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJP4</accession>
    <name>A0A103YJP4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_011214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJP4"/>
    <dbReference type="STRING" id="59895.A0A103YJP4"/>
    <dbReference type="Gramene" id="KVI10391">
        <property type="protein sequence ID" value="KVI10391"/>
        <property type="gene ID" value="Ccrd_011214"/>
    </dbReference>
    <dbReference type="OMA" id="NMQIVEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010152">
        <property type="term" value="P:pollen maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080110">
        <property type="term" value="P:sporopollenin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF135">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="73"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="615" mass="70204" checksum="09F37AC7F0BD0504" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM23</accession>
    <name>A0A103YM23_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01000102">
        <property type="protein sequence ID" value="KVI11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM23"/>
    <dbReference type="STRING" id="59895.A0A103YM23"/>
    <dbReference type="Gramene" id="KVI11512">
        <property type="protein sequence ID" value="KVI11512"/>
        <property type="gene ID" value="Ccrd_010076"/>
    </dbReference>
    <dbReference type="OMA" id="CREENHP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF756">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE PARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="101" mass="11348" checksum="D14EA140F3380587" modified="2016-04-13" version="1">MKVEVILLDRWLSSYAMRVKIALAEKGVGYECREENHPNKSPLLLQSNPIHKTIPVLVHNGKPISGRVLWGKGEDQEIAKKEFIQGLKELEGELGIKPCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM69</accession>
    <name>A0A103YM69_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, family 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000045">
        <property type="protein sequence ID" value="KVI11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM69"/>
    <dbReference type="STRING" id="59895.A0A103YM69"/>
    <dbReference type="Gramene" id="KVI11741">
        <property type="protein sequence ID" value="KVI11741"/>
        <property type="gene ID" value="Ccrd_009821"/>
    </dbReference>
    <dbReference type="OMA" id="HSMARIF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000010">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000054">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF129">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (UDP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="635" mass="71241" checksum="EF9F061BAAF127A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMB2</accession>
    <name>A0A103YMB2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000050">
        <property type="protein sequence ID" value="KVI11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMB2"/>
    <dbReference type="Gramene" id="KVI11709">
        <property type="protein sequence ID" value="KVI11709"/>
        <property type="gene ID" value="Ccrd_009871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="78" mass="8346" checksum="B674D796277D8635" modified="2016-04-13" version="1">MRAQGKGNGCDAMFMALNRGVDATDDWLLPSVDCHLFVVLESGNSVTVVKLGLLNKSGLEFGSRAKSSRMSLQVGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMC8</accession>
    <name>A0A103YMC8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase, family 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000053">
        <property type="protein sequence ID" value="KVI11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMC8"/>
    <dbReference type="Gramene" id="KVI11693">
        <property type="protein sequence ID" value="KVI11693"/>
        <property type="gene ID" value="Ccrd_009897"/>
    </dbReference>
    <dbReference type="OMA" id="PATHIWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF43">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54334" checksum="E1201A82E35E910C" modified="2016-04-13" version="1">MGSLCWQIGICIWVFLFGFIWVFQDSNIENGAVSIDGESGIAEIDTDFICATMDWWPPEKCDYGTCSWDNASLLNVDLSNKIFQNAVKAFSPLKIRLGGSLQDVLVYETEDHIKPCTPFTQNTSALFGFNEGCLPLSRWDELNSFFNETGEVLADGSTVGPWDSTNAESLMRNELSGSGVGARVTASQYAIDTTLLKNVVHEIYDGIEPKPRIISPGGFFDAKWFKEFINKTNEILDVVTHHIYNLGPGVDQGLVEKILDPSYLDGEADTFKQLKNILATSETSASAWVGEAGGAYNSGHNLVTNAFVFSGNYGLLNTTTFEPNPDYYSALLWHQLMGKTVLATNFSGTKKMRSYAHCAKKSDGITLLLINLDTTTTVNVTLTINSLLKSWGHDNHLRQPHTRKGIRMVRQDTKTGESAIREEYHLTAKDGNLHSQTMVLNGKELTVNEAGDIPPLEPLNVSISEPITVTPNSIVFAHIPSLTLNACGNVAMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNA7</accession>
    <name>A0A103YNA7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_009318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000009">
        <property type="protein sequence ID" value="KVI12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNA7"/>
    <dbReference type="STRING" id="59895.A0A103YNA7"/>
    <dbReference type="Gramene" id="KVI12274">
        <property type="protein sequence ID" value="KVI12274"/>
        <property type="gene ID" value="Ccrd_009318"/>
    </dbReference>
    <dbReference type="OMA" id="PLAGNEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF264">
        <property type="entry name" value="IQ MOTIF, EF-HAND BINDING, P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="5">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="45509" checksum="E1B317B1E911C9B3" modified="2016-04-13" version="1">MGRAARWFKALFTTKKLKDSGHRQNHNSSCVARSHTISPPDKPIYNTHSDEDDQNRHAIAVAAATAAAADAAVAAAQAAVAVVKLTSLGVSGGGGCRENSAAIKIQSQFRGYLVYKTLISLCRRYEQPLEILVRCPYAPSRKALRALKALVKLQALVRGYLVRKQAAATLRSMEALVRAQSSVCAHKLYAMNKLQDSKNISNKLVMYLQERFDETKSDYTTSVIHSRRLSSSFEPSVIDESPKIVEMDPGRPKSRSRRTNTWAWTPGYNIDNPYAQTLSSPHRHRSPARLPTPSSQNHEFEWALHVGSNRFRPVSPSKSVCTDGSSSNRSYMASTKSFNAKLRSQSAPRQRPEFGVGHKKKMSLNEMMESRSSVSYGVKMQRSSSQAQAQEATSFKNAIMGRIGGSSEIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNG6</accession>
    <name>A0A103YNG6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPsynthase alpha/beta subunit barrel-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_009278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000007">
        <property type="protein sequence ID" value="KVI12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNG6"/>
    <dbReference type="STRING" id="59895.A0A103YNG6"/>
    <dbReference type="Gramene" id="KVI12312">
        <property type="protein sequence ID" value="KVI12312"/>
        <property type="gene ID" value="Ccrd_009278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="8">
        <location>
            <begin position="79"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="185" mass="20786" checksum="B5AEF32AE1EC83B4" modified="2016-04-13" version="1" fragment="single">MAAGLRVRTQGWWSLVKEGEREYEIPYLIQEFNGFRLQESTTPSRDDRILGNIFDGIQRPLKTIAKRSGDVYIPRGVSVPALDKDILWEFQPKKLGEGDLVTSGDLYATVFENSLVEHHIALPPDAMGKITYVAPPGQYSLKDTVLELEFQGVKKKFTMLQTWPVRTPRPVASKLAADTPLLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNQ8</accession>
    <name>A0A103YNQ8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNQ8"/>
    <dbReference type="STRING" id="59895.A0A103YNQ8"/>
    <dbReference type="Gramene" id="KVI12506">
        <property type="protein sequence ID" value="KVI12506"/>
        <property type="gene ID" value="Ccrd_009097"/>
    </dbReference>
    <dbReference type="OMA" id="MMGERIN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7730" checksum="F231D53F170FFB43" modified="2016-04-13" version="1">MEGQDSGDTKQSTADMTQFVQTLLQQMMGERINELEQSINDLRTEMGAEGSPSPLSTSKKPDEPKPDEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YNY2</accession>
    <name>A0A103YNY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plant organelle RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_009137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YNY2"/>
    <dbReference type="STRING" id="59895.A0A103YNY2"/>
    <dbReference type="Gramene" id="KVI12490">
        <property type="protein sequence ID" value="KVI12490"/>
        <property type="gene ID" value="Ccrd_009137"/>
    </dbReference>
    <dbReference type="OMA" id="FPNDFMV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021099">
        <property type="entry name" value="PORR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045040">
        <property type="entry name" value="PORR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31476">
        <property type="entry name" value="PROTEIN WHAT'S THIS FACTOR 1 HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31476:SF3">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11955">
        <property type="entry name" value="PORR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PORR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="472" mass="55294" checksum="8EA792344D0BB87E" modified="2016-04-13" version="1">MGGNHGRPRPTASFLVQRSRLQSRSWHLLTQSIPIDQRAVVRAFLNQKIQIPSRNCFNQSFLIKGMFFQSHTICSCFNASRNSIGIRVWYQFTASISSLKVVWRKDQKLDQAIQNDKSWRQCAKVVKEVLNEPGQVIPLRYLEKRRERLRLPIKIQTFLSRNPGLFDVYYDRIKPKTEPVKFLRFSDRLQRVLDEEERIYLENEPLIVAKLCKLLMMAKNNVVNAEKLVHVKREFGFPNDLMVNLIPKYPEHFKLIGSPGEGNSFLELVSWNPIFAKSVIEQRADEESELTGIKIRPSFNWKLPKGFLIRKEMREWIRDWMELPYISPYDDASNFDQASQEMEKRTVGVFHELLSLSLYKRIPVPILGKFTEEYRFSNAFSSVFTRHSGIFYMSLKGGIKTAMLREAYKGDELIDRDPLLEINDNFIELLAEGHEQREEQLKLQKEAVQNDMEMVAMRNNPELTESEELYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRT4</accession>
    <name>A0A118JRT4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005903">
        <property type="protein sequence ID" value="KVH87717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRT4"/>
    <dbReference type="Gramene" id="KVH87717">
        <property type="protein sequence ID" value="KVH87717"/>
        <property type="gene ID" value="Ccrd_024999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="437" mass="49577" checksum="F0A43787CE4B3349" modified="2016-04-13" version="1">MEGHREWSQSGTKVDHIRHQSLEIEGGIDECTTTRHHPSRLIQPGEACIDVASLHRAIGVGLGGDFYIEKWSKRLPGTERERRLGKRKTKDQVPEREQIGCRSGDCQLGRLDLEYGPRRRCEERTINVCSIRISFSILAMDEPYGKAHASSAFFFHSMPFFLISFPFSPFINSITSFATSSLFTLLSISIATPHLLQHIQQFVCWSPKNGQHIIGTPLEILSIVEFHPLCIQRANSVARRKYRRKGVENVGFEFMIRVENDGGSRFRSLYLSSKEFNHVFITRALEGCQEWSRSRRKGSHVGRRSPEIGGGIRRDKLRVQDFEPPAPASLVGLEQVDETGAGMLSKMFNFSTGGPTTELLENQINYQHHRNQRPNSATGDWYGNNTAQAITQISFLTIFFSPSSPPEFFNFFFNTSHVVAKRCPIFHFHPSSSTDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JS54</accession>
    <name>A0A118JS54_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005596">
        <property type="protein sequence ID" value="KVH88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JS54"/>
    <dbReference type="STRING" id="59895.A0A118JS54"/>
    <dbReference type="Gramene" id="KVH88061">
        <property type="protein sequence ID" value="KVH88061"/>
        <property type="gene ID" value="Ccrd_024552"/>
    </dbReference>
    <dbReference type="OMA" id="QMLGTFN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF8">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159614" evidence="8">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="331" mass="36436" checksum="91E9015AD8768EA5" modified="2016-04-13" version="1">MIEMGRQRWWFTVVVVVAWWWEGVIGAGQAPAIWVMGDSLVDSGNNNFMRSIARADYFPYGCDYYRGASGRFCNARTFSDILGDWLGIPAPPPFSDPGTAGNRLLGGVNYASASGGILDESGQHYQVVNFETTLGQLRTMLSPEDLTQLLSNSIVVMVFGSNDYLNNYLMPTVYTSSRTYTPEAFATLLLNHYARQIHALYSLGLRKFFLPGLGPLGCIPNQLATGQAAPGRCVDSVNQLIGPFNEGLKNLVDQFNGFTVRDRACCGIGRNQGQITCLPMTTPCFNRDQYVFWDAFHPTQAANAVLAQRAYSGSTNDCSPINVQQLAQIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSK2</accession>
    <name>A0A118JSK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_008677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005241">
        <property type="protein sequence ID" value="KVH89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSK2"/>
    <dbReference type="STRING" id="59895.A0A118JSK2"/>
    <dbReference type="Gramene" id="KVH89334">
        <property type="protein sequence ID" value="KVH89334"/>
        <property type="gene ID" value="Ccrd_008677"/>
    </dbReference>
    <dbReference type="OMA" id="DICHATA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000001">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159651" evidence="9">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="17608" checksum="45549EA35FA20160" modified="2016-04-13" version="1">MDTGRSIRVRFSFTFLVLTLVLVFGVTSGADDKDKEECTEQLVGLATCLPYVGGNAKSPTPDCCSGLKQVLNTNKKCLCVVIKDRNDPDLGLTINVTLALGLPTVCHAPANVSKCPASANMTSTRGSATNLKQPGGNISNNGRTWLKLEVILMIIVSSIFTSASIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JST7</accession>
    <name>A0A118JST7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_008675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005240">
        <property type="protein sequence ID" value="KVH89337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JST7"/>
    <dbReference type="STRING" id="59895.A0A118JST7"/>
    <dbReference type="Gramene" id="KVH89337">
        <property type="protein sequence ID" value="KVH89337"/>
        <property type="gene ID" value="Ccrd_008675"/>
    </dbReference>
    <dbReference type="OMA" id="EITIFRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH89337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="37445" checksum="5403BB2A3B526D85" modified="2016-04-13" version="1" fragment="single">MMVDEVAVARGSVFFYGVGHMLNDITAACWFTYLLVWHGAGSILVAVSFSSVFGGCVPCIIFGNESSSLQTIGYSFFAAVFNVGWAATQVANLSLYAIAFSVFHIRPSKTTSDVENQYRWIAYSSIFIGCCFVVVFHIGTKEPRLITNVSQAFLAFYVINDLRMAQSSKALVRNYTNLLIDHEILLSFRLFSLPMKHDLQIPAMIYICSFIVSIILQELTWTGQRLKAFFSVGGVLWILCGSAIFFMPRSMKDVIYLVGEDVKGCAFVYGSLSFLDKMSCGIALWALESYQMYTCFSVSRYGLGLVPAICALAGVIVTCTMKLEKPRLKPLRVPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTE9</accession>
    <name>A0A118JTE9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTE9"/>
    <dbReference type="Gramene" id="KVH90102">
        <property type="protein sequence ID" value="KVH90102"/>
        <property type="gene ID" value="Ccrd_007990"/>
    </dbReference>
    <dbReference type="OMA" id="QERTEIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51774">
        <property type="entry name" value="NAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="4">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="568" mass="65456" checksum="B27F1D5BF80B866D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTR6</accession>
    <name>A0A118JTR6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPR family. PCMP-E subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTR6"/>
    <dbReference type="Gramene" id="KVH90042">
        <property type="protein sequence ID" value="KVH90042"/>
        <property type="gene ID" value="Ccrd_007957"/>
    </dbReference>
    <dbReference type="OMA" id="WNACISN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000196">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015">
        <property type="entry name" value="OS07G0578800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015:SF1814">
        <property type="entry name" value="OS11G0583200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="642" mass="70728" checksum="25718096DA1360ED" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTU9</accession>
    <name>A0A118JTU9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTU9"/>
    <dbReference type="STRING" id="59895.A0A118JTU9"/>
    <dbReference type="Gramene" id="KVH90547">
        <property type="protein sequence ID" value="KVH90547"/>
        <property type="gene ID" value="Ccrd_007419"/>
    </dbReference>
    <dbReference type="OMA" id="KIKHDNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560">
        <property type="entry name" value="POLYKETIDE CYCLASE/DEHYDRASE/LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65824" checksum="930F9C2DDA5FCB18" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU74</accession>
    <name>A0A118JU74_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01004871">
        <property type="protein sequence ID" value="KVH92034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU74"/>
    <dbReference type="STRING" id="59895.A0A118JU74"/>
    <dbReference type="Gramene" id="KVH92034">
        <property type="protein sequence ID" value="KVH92034"/>
        <property type="gene ID" value="Ccrd_005937"/>
    </dbReference>
    <dbReference type="OMA" id="LHTMKVG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044197">
        <property type="entry name" value="FKBP17-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47860">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP17-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47860:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP17-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="24852" checksum="FE8B92BB1F0119B4" modified="2016-04-13" version="1">MMLSCGVSTSSYRVPHVVTFCYNNPNHPTAKHGELESVVTRRALSLLATSMATATTAMFSVPILFCDSSARRSEASASASATSTSTSTATGTQFSELPQSGGVKALDLRIGDGDSPVNGDKVAIHYYGRLAAKQGWRFDSTYDHKDETVQVIQGMEEAVRSMKVGGIRRVIIPPSQGYQNMSQEPIPPNFFDRQRLFTTIFNPTRLANGEGSTLGILIFDIELVSLNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUD9</accession>
    <name>A0A118JUD9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_006088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004900">
        <property type="protein sequence ID" value="KVH91884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUD9"/>
    <dbReference type="STRING" id="59895.A0A118JUD9"/>
    <dbReference type="Gramene" id="KVH91884">
        <property type="protein sequence ID" value="KVH91884"/>
        <property type="gene ID" value="Ccrd_006088"/>
    </dbReference>
    <dbReference type="OMA" id="TIRMENR"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010253">
        <property type="term" value="P:UDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000236">
        <property type="entry name" value="Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH91884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="301" mass="33629" checksum="1409828A53199CE9" modified="2016-04-13" version="1">MGSQSNGSPASPLKFLIYGRTGWIGGLLGKLCEAQGIDYTYGSGRLESRETLIADLAAVNPSHVFNAAGVTGRPNVDWCESHKVETIRTNVVGTLTLADVCREKGLILINYATGCIFEYDSEHQLGSGVGFKEEDTPNFIGSFYSKTKAMVEELLKEYDNVCTLRVRMPISSDLTNPRNFITKISRYEKVVNIPNSMTILDELLPISIEMAKRNLTGIYNFTNPGCVSHNEVLEMYREYIDSSFTWKNFNLEEQAKVIVAPRSNNELDTTKLKTEFPELLSIKESLVKFVFEPNRKTPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUP0</accession>
    <name>A0A118JUP0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004820">
        <property type="protein sequence ID" value="KVH92381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUP0"/>
    <dbReference type="Gramene" id="KVH92381">
        <property type="protein sequence ID" value="KVH92381"/>
        <property type="gene ID" value="Ccrd_005568"/>
    </dbReference>
    <dbReference type="OMA" id="SNACRAP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33168">
        <property type="entry name" value="STRESS INDUCED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="110" mass="12941" checksum="DF7A0EFD773C3A44" modified="2016-04-13" version="1">MATTTDFITSTAQRRSSYFSGCMSPSCVPVEEQYTRIKSGRRGADRQRRRWRKLMNKMVEESKRSIYGSSKPLEFRYDALSYAQNFDDGNHRDELYLYERQCSQVLPECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVZ0</accession>
    <name>A0A118JVZ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004516">
        <property type="protein sequence ID" value="KVH94837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVZ0"/>
    <dbReference type="STRING" id="59895.A0A118JVZ0"/>
    <dbReference type="Gramene" id="KVH94837">
        <property type="protein sequence ID" value="KVH94837"/>
        <property type="gene ID" value="Ccrd_003093"/>
    </dbReference>
    <dbReference type="OMA" id="HKCWVGS"/>
    <dbReference type="OrthoDB" id="1930763at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037766">
        <property type="entry name" value="FHY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37723">
        <property type="entry name" value="PROTEIN FAR-RED ELONGATED HYPOCOTYL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37723:SF1">
        <property type="entry name" value="PROTEIN FAR-RED-ELONGATED HYPOCOTYL 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="239" mass="27341" checksum="2CFAD2BFDBC571AC" modified="2016-04-13" version="1">MNSKLEMDEDPCGINRKLYMNKRKFHHGSLDLPVSKHACFEKSSNAETCFPSNIQSDIEDLRNSRKERSTYNSHSIDDQIEQGSEKDSNSFSEDADSVMSVSIDSKNELHYLKICPPDQNSDASVNWGSRFFDSSVNYLDRSETKACDENFMNPAYNVYESPSFEEQQMDCGNIDEFDSSEYKNGGTKPLDDLFCSDGVIPDNFVLSSGRWNVNQDTEQGTEKMTIDKEFEQYFSMLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWH8</accession>
    <name>A0A118JWH8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_003469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004552">
        <property type="protein sequence ID" value="KVH94479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWH8"/>
    <dbReference type="STRING" id="59895.A0A118JWH8"/>
    <dbReference type="Gramene" id="KVH94479">
        <property type="protein sequence ID" value="KVH94479"/>
        <property type="gene ID" value="Ccrd_003469"/>
    </dbReference>
    <dbReference type="OMA" id="YPEYWEK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033326">
        <property type="entry name" value="BAH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764:SF6">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH94479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="309" mass="35351" checksum="1AF921A424219445" modified="2016-04-13" version="1">MKFCKKYEEYMQTQDQKKLPGVGFKNLKKILKRCRRDMNHSRSSLQSQSSLLLNDSSDNTSALCLHPCPVCDGYFFPSLMKEMSMVVGCFNKRAQKVLDVHLATGFRKYFVWCRDKFQGKHGALIQEGENLVGQAFRSQVKSMHMEILQSPWLCELIAFHINLSETKADMRKGSELFEGCSLIFSDGKPSLSCELSDTVKLEIDLTCSVCLDTVFDPVYLTCGHIFCFMCACKSGSVTIVDGLKATKPTAKCPLCREVWTFSVPSFFKLSIINICCPEYWEERLRTERAERIRQTKEHWQSQSRAFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWS7</accession>
    <name>A0A118JWS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_001547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004324">
        <property type="protein sequence ID" value="KVH96367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWS7"/>
    <dbReference type="Gramene" id="KVH96367">
        <property type="protein sequence ID" value="KVH96367"/>
        <property type="gene ID" value="Ccrd_001547"/>
    </dbReference>
    <dbReference type="OMA" id="QTISAVC"/>
    <dbReference type="OrthoDB" id="1478287at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="11">
        <location>
            <begin position="225"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="12">
        <location>
            <begin position="477"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH96367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="947" mass="108087" checksum="DF4EF3483DD16EB1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWW1</accession>
    <name>A0A118JWW1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase, ESSS subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004529">
        <property type="protein sequence ID" value="KVH94735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWW1"/>
    <dbReference type="STRING" id="59895.A0A118JWW1"/>
    <dbReference type="Gramene" id="KVH94735">
        <property type="protein sequence ID" value="KVH94735"/>
        <property type="gene ID" value="Ccrd_003207"/>
    </dbReference>
    <dbReference type="OMA" id="LETWAHE"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="12847" checksum="DE86E2518FAA8E0A" modified="2016-04-13" version="1">MPSAKPFSAAAGMLRSRLTSTLRQRSGDGPSRWTTPGHQDRPNGYFLNRTPLPPGQSRKWEDWELPCYVTSFLTIVILGVGLNAKPDLTLETWAHQKAVERLEAQRQILAADDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYC5</accession>
    <name>A0A118JYC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_023335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003798">
        <property type="protein sequence ID" value="KVH98424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYC5"/>
    <dbReference type="STRING" id="59895.A0A118JYC5"/>
    <dbReference type="Gramene" id="KVH98424">
        <property type="protein sequence ID" value="KVH98424"/>
        <property type="gene ID" value="Ccrd_023335"/>
    </dbReference>
    <dbReference type="OMA" id="QWRDKLS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="entry name" value="Bifunctional nuclease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15160:SF3">
        <property type="entry name" value="BIFUNCTIONAL NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15160">
        <property type="entry name" value="VON HIPPEL-LINDAU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="Hypothetical protein TM0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH98424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="31736" checksum="3F5511833B4FEE21" modified="2016-04-13" version="1">MMSSLQGPVVCPSVHRKQGEFHAVPAVNGSLNKTKILRSGMWGFRGVYSHRVHIRDQPRSQTVTCTFSSSSNGNGSMAESFNENDSDYVNSSVVEAVEVKSGPEGFMIKMRDGRHLRCAHNNPQGGHLPDYAPHPAIVLKMEDGTGLLLPIIWRCLVYYSWRQFAMFKFFHLCVSSANRNCCVVYQARPTMYQVVREMVDKMGYKLDDETDCVSFDLRPSDAINIAVRCKVPIQVNKFLAYSDGMKVVESAKPSLLGSSSDGLIFKELDRGMNLYIIEVGFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYT4</accession>
    <name>A0A118JYT4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional coactivator Hfi1/Transcriptional adapter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYT4"/>
    <dbReference type="Gramene" id="KVH99039">
        <property type="protein sequence ID" value="KVH99039"/>
        <property type="gene ID" value="Ccrd_022729"/>
    </dbReference>
    <dbReference type="OMA" id="NKVCFRV"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF35">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR HFI1_TRANSCRIPTIONAL ADAPTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="44211" checksum="AEF6F953BB65B218" modified="2016-04-13" version="1">MQPPQQHSWNNLAEIKGQLIKKLGFERSKQYLDYLNRFLSLKLSKTEFDKLCLRTVGKDNIRLHNQLIRAVLKSACTGKLPIVIHDDSSRTVGNKKPSDGVYHQNGSIPVVTHVTSPLSLGNGDILPPSPRKARTGSRERRGGDRRSALGPNGKTNYGSLTSSIPQSADFSSLENGDSSSSDTRRAVHQQELIQEAENGGGSPDGFVGVHHKEKTESLGRKKDGKSVSDRISLHAPLGVPYCPVSIGGAYSAIPLAASSSSRCVGVLHSDGLLETTTLKDHMEQICGAQGLQGVSMDCANVVNSGLDGYLKGLIGSCMELNRARSVHELTKSGSIKNPTHSRPLNGVISHHQIQNSSWPLNAMQENEPKQLVTLLDFRVAMELNHKKLGEDWPILLEKICTHAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZC8</accession>
    <name>A0A118JZC8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_021951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003413">
        <property type="protein sequence ID" value="KVH99787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZC8"/>
    <dbReference type="Gramene" id="KVH99787">
        <property type="protein sequence ID" value="KVH99787"/>
        <property type="gene ID" value="Ccrd_021951"/>
    </dbReference>
    <dbReference type="OMA" id="MIARVGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH99787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27538" checksum="C397A3C8D2A134E3" modified="2016-04-13" version="1">MSSSERKSLIGTNPPSPQRGGSGEDKGSSMTPRGVYAAVSYMACAVMLVLFNKAALSSYSFPCANVITLFQMICSCCFLYALRSWKFITFSSDILPLTDNSTKFVPLKTSVRGVNVPMYTTLRRTTVVFTMFVEFILVGQKYTRSIIGSVALIVFGAFVAGSRDLSFDSYSYAVIVLLLSCVLAFFLNYSIFLNTTLNSAVTQTICGNLKDLFTIAFGWMVFGGLPFDLLNVIGQLLGFVGSGLYAYCKLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZQ4</accession>
    <name>A0A118JZQ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003395">
        <property type="protein sequence ID" value="KVI00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZQ4"/>
    <dbReference type="STRING" id="59895.A0A118JZQ4"/>
    <dbReference type="Gramene" id="KVI00257">
        <property type="protein sequence ID" value="KVI00257"/>
        <property type="gene ID" value="Ccrd_021498"/>
    </dbReference>
    <dbReference type="OMA" id="HGSIDEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="322" mass="36579" checksum="F550B40940627FA7" modified="2016-04-13" version="1">MSSDTAVSSGHGSIDEYISQLMQCKPLSEQEVRVLCEKAKEILMDESNVQPVKSPVTICGDIHGQFHDLAELFRIGGKCPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPQRITILRGNHESRQITQVYGFYDECLRKYGNASVWKIFTDLFDYLPLTALVESEIFCLHGGLSPSIETLDNIRNFDRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQVSPLPSFYLDISEQFNHTNSLKLIARAHQLVMEGFNWGHEQKVVTIFSAPNYCYRCGNMASVLEVDDCKGHTFIQFEPAPRRGEPDVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0D1</accession>
    <name>A0A118K0D1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003130">
        <property type="protein sequence ID" value="KVI01113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0D1"/>
    <dbReference type="STRING" id="59895.A0A118K0D1"/>
    <dbReference type="Gramene" id="KVI01113">
        <property type="protein sequence ID" value="KVI01113"/>
        <property type="gene ID" value="Ccrd_020609"/>
    </dbReference>
    <dbReference type="OMA" id="GIGAIWG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000051">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000102">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF1">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI01113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="522" mass="56603" checksum="F02524CEA5AE1EE6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0X9</accession>
    <name>A0A118K0X9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002666">
        <property type="protein sequence ID" value="KVI02025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0X9"/>
    <dbReference type="STRING" id="59895.A0A118K0X9"/>
    <dbReference type="Gramene" id="KVI02025">
        <property type="protein sequence ID" value="KVI02025"/>
        <property type="gene ID" value="Ccrd_019693"/>
    </dbReference>
    <dbReference type="OMA" id="CINGEDP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13846">
        <property type="entry name" value="CuRO_1_AAO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000016">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034273">
        <property type="entry name" value="CuRO_1_AAO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF484">
        <property type="entry name" value="L-ASCORBATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159859" evidence="3">
        <location>
            <begin position="26"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="162"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="335"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="55428" checksum="FABFAEE7056A38C9" modified="2016-04-13" version="1">MGEQRCITSSFLALVLLLLLQLINGEDPYRFFTWNVSYGDIYPLGVKQQGILINGQFPGPLIESVTNDNLVINVFNSLDEPFLLSWNGVMQRRNSWQDGVFGTNCPIPPGQNFTYNLQVKDQIGSFFYFPSLAFHKAAGGYGGIKIASRSVIPVPFAPPAGDYTILAGDWFKQNHTDLKAILDNGNDLPFPDGILINGRGSDGFTFTVDQGKTYRFRVSNVGLTTSINFRIQGHKLILVEVEGTHSLQNTYDSIDIHLGQSYSVLVTADQPPKDYYIVVSTRRNLTASGPRPNPQGSYHYGLINTTRTIRLVNSAPVINGKQRYAVNSVSFIPPDTPLKLADYFKISGVFSLGSIQDSPTGGDHLQTAVMPADFRGYVEVVFENPEDTVQSWHVDGHHFFVVGMDGGQWSTASRTGYNLRDTISRVTVQVYPKSWTAVYMPLDNVGMWNVRSENWARQYLGQQFYHRVYSPANSWRDEAPIPNNVLLCGRAVGHHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K265</accession>
    <name>A0A118K265_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14b/L23e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K265"/>
    <dbReference type="SMR" id="A0A118K265"/>
    <dbReference type="STRING" id="59895.A0A118K265"/>
    <dbReference type="Gramene" id="KVI03870">
        <property type="protein sequence ID" value="KVI03870"/>
        <property type="gene ID" value="Ccrd_017843"/>
    </dbReference>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="1333466at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="15015" checksum="BDD40B074432B368" modified="2016-04-13" version="1">MSKRGRGGSAGNKFRMSLGLPVAATVNCADNTGAKNLYIISVKGIKGRLNRLPSACVGDMVMATVKKGKPDLRKKVMPAVIVRQRKPWRRKDGVFMYFEDNAGVIVNPKGEMKGSAITGPIGKECADLWPRIASAANAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2R0</accession>
    <name>A0A118K2R0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor, K-box</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001918">
        <property type="protein sequence ID" value="KVI04755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2R0"/>
    <dbReference type="Gramene" id="KVI04755">
        <property type="protein sequence ID" value="KVI04755"/>
        <property type="gene ID" value="Ccrd_016924"/>
    </dbReference>
    <dbReference type="OMA" id="EKYARCS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000003">
        <property type="entry name" value="MADS-box transcription factor MADS-MC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51297">
        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22101" checksum="A23030A00775886F" modified="2016-04-13" version="1">MVRGKVEMKRIENATSRQVTFSKRRIGLLKKACELSVLCDAEVALLIFSQKGELYEFSSSNIKKTIQKYRDNAKANESCNEIEPQNQQLKHDATIIQKKIEQLEVSQRKLMGQNLASCSVDELLKLDSKLEHSLTIIRARKERFLLEENTRLCQQNTSLCEKEIHVTATSRESIQNLEVETELFIGSRLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K456</accession>
    <name>A0A118K456_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_014696</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001539">
        <property type="protein sequence ID" value="KVI06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K456"/>
    <dbReference type="STRING" id="59895.A0A118K456"/>
    <dbReference type="Gramene" id="KVI06945">
        <property type="protein sequence ID" value="KVI06945"/>
        <property type="gene ID" value="Ccrd_014696"/>
    </dbReference>
    <dbReference type="OMA" id="LVEWAMK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000252">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000001">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF62">
        <property type="entry name" value="OS05G0423500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159941" evidence="15">
        <location>
            <begin position="25"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="428"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="756" mass="84759" checksum="7DB1A57E07286483" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4B9</accession>
    <name>A0A118K4B9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_014290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4B9"/>
    <dbReference type="STRING" id="59895.A0A118K4B9"/>
    <dbReference type="Gramene" id="KVI07278">
        <property type="protein sequence ID" value="KVI07278"/>
        <property type="gene ID" value="Ccrd_014290"/>
    </dbReference>
    <dbReference type="OMA" id="RERNICF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000033">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="48"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="290" mass="32016" checksum="226F9DA9E86C4DA0" modified="2016-04-13" version="1">MREILNIQGGQCGNQIGAKFWEVICDEHGIDPTGQYTGSTADLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSIRSGPIGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDALQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMMSSTFIGNSTSIQEMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATAEEDQEYGGGGGDEEGGEAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4F7</accession>
    <name>A0A118K4F7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_014279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4F7"/>
    <dbReference type="STRING" id="59895.A0A118K4F7"/>
    <dbReference type="Gramene" id="KVI07367">
        <property type="protein sequence ID" value="KVI07367"/>
        <property type="gene ID" value="Ccrd_014279"/>
    </dbReference>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF6">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI07367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="751" mass="84932" checksum="8C251B2F89F3906B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5T5</accession>
    <name>A0A118K5T5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad21/Rec8-like protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001055">
        <property type="protein sequence ID" value="KVI09570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5T5"/>
    <dbReference type="STRING" id="59895.A0A118K5T5"/>
    <dbReference type="Gramene" id="KVI09570">
        <property type="protein sequence ID" value="KVI09570"/>
        <property type="gene ID" value="Ccrd_012049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="684" mass="74662" checksum="AD72FDF7F9626304" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6L4</accession>
    <name>A0A118K6L4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_010775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000994">
        <property type="protein sequence ID" value="KVI10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6L4"/>
    <dbReference type="STRING" id="59895.A0A118K6L4"/>
    <dbReference type="Gramene" id="KVI10832">
        <property type="protein sequence ID" value="KVI10832"/>
        <property type="gene ID" value="Ccrd_010775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="9931" checksum="C437C7F5CE0E642B" modified="2016-04-13" version="1">MARSGGVRWMAIRYVGGHTIVVCGFLVNFKCKVPTEDLNLVVTITSYEDLVAVVEEYNRVSPNLKIRVVLFPVGLLKTISSVFICYFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6P9</accession>
    <name>A0A118K6P9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000956">
        <property type="protein sequence ID" value="KVI11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6P9"/>
    <dbReference type="STRING" id="59895.A0A118K6P9"/>
    <dbReference type="Gramene" id="KVI11012">
        <property type="protein sequence ID" value="KVI11012"/>
        <property type="gene ID" value="Ccrd_010586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="15607" checksum="25DEAE4F47BD4120" modified="2016-04-13" version="1">MSSNILRRVYQRSSSILTRYQPISTLFVSQFFTSSDKPQNHASGLELLSNNASGVSSIWYKRLNFSCGSTRLLFSTQAAVEPSTSDGLTVDGIIANEWTILDENESDWKSHASAIAQSIGLIKKRLQESRSEIMQSVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124RKB5</accession>
    <name>A0A124RKB5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH:ubiquinone oxidoreductase, 30kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007266">
        <property type="protein sequence ID" value="KVH01119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124RKB5"/>
    <dbReference type="STRING" id="59895.A0A124RKB5"/>
    <dbReference type="Gramene" id="KVH01119">
        <property type="protein sequence ID" value="KVH01119"/>
        <property type="gene ID" value="Ccrd_026015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH01119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="7842" checksum="6D7B40B5410140DE" modified="2016-04-13" version="1" fragment="single">ARRFKARPTTPRALIHKPVTGTNNIKKCNQQYGVDQPEEVCIKVFASRRDPRIPSVFWVWKSVDFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF91</accession>
    <name>A0A124SF91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF91"/>
    <dbReference type="STRING" id="59895.A0A124SF91"/>
    <dbReference type="Gramene" id="KVI02506">
        <property type="protein sequence ID" value="KVI02506"/>
        <property type="gene ID" value="Ccrd_019254"/>
    </dbReference>
    <dbReference type="OMA" id="TMFQARM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF68">
        <property type="entry name" value="OS06G0727800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="39414" checksum="E89DBE7B6A0EE50B" modified="2016-04-13" version="1">MGTITRRGMVRRPNETMRLIVTTFISVVFGLFLGVSFPTISLTKMNLPSTLLPSIDLGYIEDKYSGLSSQALLNIWSSIRRGEGILSHEPEDTKIWVPTNPRGAERLPPGVVASESDLYLRRLYGSPSEDLIIKPRYLVTFTVGYEQKDNIDNAVKKFSENFTILLFHYDGRTSEWNEFEWSKRAIHVSVLKQTKWYINLVKKHGLEISQPGLSANSGLTWQMTRKRDDSEVHKEAEERDGWCTDPHLPPCAAFVEIMAPVFSRNAWRCVWHMIQNDLVHGWGLDFALRRCVEGTAENGKAPWEGVRERCQKEWTTFQIRMTLAERAYLKMTNRLDQLNSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFC5</accession>
    <name>A0A124SFC5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002627">
        <property type="protein sequence ID" value="KVI02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFC5"/>
    <dbReference type="Gramene" id="KVI02807">
        <property type="protein sequence ID" value="KVI02807"/>
        <property type="gene ID" value="Ccrd_018901"/>
    </dbReference>
    <dbReference type="OMA" id="RMTKRDP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="266" mass="29644" checksum="CEBF2DC5DC7B81D6" modified="2016-04-13" version="1">MGEVVVVRNKQVILKDYVNGYMKPSDLVVTSDTTIPLELPKNDGGLILSKNLYLSCDPYMRNRMNEAVAGSYITSFTPGLKGDFVFVSAASGAVGQLVGQFAKLFGCYVVGSAGSKEKNKFGFDEAFNYKEEQDLDIALKRYFPNGIDIYFENVGGKMLDEVLSNMRIQGRIAVCGMISQYNLDRVEGIYNLHLLIFKRIRMQGFLVFDHYHLYPKFLDMIVPLIQEGKIAYVEDIVEGLENAPTALAGLYTGKNVGKQVVAVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGN4</accession>
    <name>A0A124SGN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lateral organ boundaries domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001537">
        <property type="protein sequence ID" value="KVI06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGN4"/>
    <dbReference type="STRING" id="59895.A0A124SGN4"/>
    <dbReference type="Gramene" id="KVI06961">
        <property type="protein sequence ID" value="KVI06961"/>
        <property type="gene ID" value="Ccrd_014681"/>
    </dbReference>
    <dbReference type="OMA" id="FCYSQGA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31529">
        <property type="entry name" value="LOB DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31529:SF23">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14499" checksum="0FEB58C7E35E802A" modified="2016-04-13" version="1">MTASGSSSSCGACKFLRRKCTNECVFTPYFCYSQGAHHFAAVHKVFGASNVSKLLMKLPLQNRSEAAISISYEALARMEDPIYGCIAQILALEQQEIGDLNAGLPSSFQFNNTSISDHLNQPLLFAAPHASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHR9</accession>
    <name>A0A124SHR9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ccrd_011160</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001020">
        <property type="protein sequence ID" value="KVI10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI10412">
        <property type="protein sequence ID" value="KVI10412"/>
        <property type="gene ID" value="Ccrd_011160"/>
    </dbReference>
    <dbReference type="OMA" id="NECNCTA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000001">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001019">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000924">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF932">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176257" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="22"/>
            <end position="3745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1401"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1708"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="288"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="24">
        <location>
            <begin position="607"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="672"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="986"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1249"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="24">
        <location>
            <begin position="1304"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1349"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="1729"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="24">
        <location>
            <begin position="2045"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="2146"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="2367"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="24">
        <location>
            <begin position="2685"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="2754"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="3104"/>
            <end position="3228"/>
        </location>
    </feature>
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        <location>
            <begin position="3367"/>
            <end position="3403"/>
        </location>
    </feature>
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        <location>
            <begin position="3422"/>
            <end position="3504"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="3466"/>
            <end position="3745"/>
        </location>
    </feature>
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        <location>
            <begin position="3086"/>
            <end position="3109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KVI10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="3745" mass="422607" checksum="1F7A82F45236F66E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103KPU8</accession>
    <name>A0A103KPU8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009251">
        <property type="protein sequence ID" value="KVF61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103KPU8"/>
    <dbReference type="Gramene" id="KVF61477">
        <property type="protein sequence ID" value="KVF61477"/>
        <property type="gene ID" value="Ccrd_026732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="At5g50450/At1g67340-like"/>
    </dbReference>
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        <property type="entry name" value="MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758:SF2">
        <property type="entry name" value="OJ1485_B09.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVF61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16657" checksum="453FB457A905AD15" modified="2016-04-13" version="1">MEEDEEDXICLNRYLMKLLSPSYASSILPLLLRLISSLFFLQNLISSVLCFDFMFIDIRFYCLQNRGSGASLMVKVVIKSHAPALYSLALIQFNGSGGLKNDKDLRAGVALCARAGFLSHADDLRELGLCLQCKHCNFAFFLPLTTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SQU4</accession>
    <name>A0A103SQU4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_026108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007423">
        <property type="protein sequence ID" value="KVG91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103SQU4"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF96">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="14">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVG91780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114947" checksum="810E38764D6F5B7F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103US66</accession>
    <name>A0A103US66_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_025796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006881">
        <property type="protein sequence ID" value="KVH40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103US66"/>
    <dbReference type="STRING" id="59895.A0A103US66"/>
    <dbReference type="Gramene" id="KVH40592">
        <property type="protein sequence ID" value="KVH40592"/>
        <property type="gene ID" value="Ccrd_025796"/>
    </dbReference>
    <dbReference type="OMA" id="ITMASEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF85">
        <property type="entry name" value="MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="134"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="272"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="576" mass="64021" checksum="B2E2343AF98BA296" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VFK3</accession>
    <name>A0A103VFK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeate O-methyltransferase (COMT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_025697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006736">
        <property type="protein sequence ID" value="KVH53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH53040">
        <property type="protein sequence ID" value="KVH53040"/>
        <property type="gene ID" value="Ccrd_025697"/>
    </dbReference>
    <dbReference type="OMA" id="LVWVLHD"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000294">
        <property type="entry name" value="O-methyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="39895" checksum="744F3C5CA1A7044A" modified="2016-04-13" version="1">MATENKEKRIXSKEEEXAAQQELWKYISGFIPMALVKCSIDLGIPDILENHETPMTLAELASKLECSQSVLYRIMRFLIHYKIFQEQPLSKTSIGYAQTPLSRLLTRHGKNTMVDLVLLGNSPIMLAPWHKLSAWVLGNGKFPFEATHGKDLWGFNSENPDHSNLFNNAMACATRVEVAAVIEGCPEVFEGLKTMVDVGGGDGTALRCIVETCPWIKGINYDLPHVVSVAPTSIGVEHVGGNMFDHVPKADATYLLKVLHDWTDEKCIDILKNCRAAIPQDTGKLIIVDTIIGHKEDDEFKEMGLLLDMVMMALIXNGKERTLEEWSYLFHEAEFTRYTIKKIRNYLSVFEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X3P4</accession>
    <name>A0A103X3P4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006408">
        <property type="protein sequence ID" value="KVH83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X3P4"/>
    <dbReference type="Gramene" id="KVH83535">
        <property type="protein sequence ID" value="KVH83535"/>
        <property type="gene ID" value="Ccrd_025470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="60" mass="6757" checksum="6A3297A8194F5FCD" modified="2016-04-13" version="1">MSLKVKGGIDYVLELEEKDLCQLISFQHLSFDPDGKLDYMGFNEKNVKLSGFDLKGVFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBP4</accession>
    <name>A0A103XBP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_024958</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01005868">
        <property type="protein sequence ID" value="KVH87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBP4"/>
    <dbReference type="STRING" id="59895.A0A103XBP4"/>
    <dbReference type="Gramene" id="KVH87754">
        <property type="protein sequence ID" value="KVH87754"/>
        <property type="gene ID" value="Ccrd_024958"/>
    </dbReference>
    <dbReference type="OMA" id="MIELCHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000539">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF10">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="670" mass="76195" checksum="BE575AC0F6665382" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDF6</accession>
    <name>A0A103XDF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005346">
        <property type="protein sequence ID" value="KVH88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDF6"/>
    <dbReference type="STRING" id="59895.A0A103XDF6"/>
    <dbReference type="Gramene" id="KVH88712">
        <property type="protein sequence ID" value="KVH88712"/>
        <property type="gene ID" value="Ccrd_025979"/>
    </dbReference>
    <dbReference type="OMA" id="IRTADCN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DYW" evidence="2">
        <location>
            <begin position="74"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="164" mass="18879" checksum="C33CB2871BE31191" modified="2016-04-13" version="1" fragment="single">MLSSIYAKAGRWKDFSKVRALMKEKGLIRTADCNYIEHGHMIHRFLLNDQAHLESESIYAKVDEVIKKIQKARYVPNSEFVLHDVEEEVKESLVSKHSEKLAIAFGLLVCNDSKPLTIAKNLRICGDCHNMAKFVSFVEKHKIIIRDTRRFHHFADGLCSCGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDG8</accession>
    <name>A0A103XDG8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005344">
        <property type="protein sequence ID" value="KVH88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDG8"/>
    <dbReference type="STRING" id="59895.A0A103XDG8"/>
    <dbReference type="Gramene" id="KVH88725">
        <property type="protein sequence ID" value="KVH88725"/>
        <property type="gene ID" value="Ccrd_025940"/>
    </dbReference>
    <dbReference type="OMA" id="SIGHEYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF47">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE PROTEIN (DUF1336)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="224"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="758" mass="85119" checksum="A56EBE33C1478EE0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG60</accession>
    <name>A0A103XG60_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005115">
        <property type="protein sequence ID" value="KVH90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG60"/>
    <dbReference type="STRING" id="59895.A0A103XG60"/>
    <dbReference type="Gramene" id="KVH90165">
        <property type="protein sequence ID" value="KVH90165"/>
        <property type="gene ID" value="Ccrd_007842"/>
    </dbReference>
    <dbReference type="OMA" id="WEDINIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008581">
        <property type="entry name" value="DUF863_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167:SF29">
        <property type="entry name" value="T28K15.14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05904">
        <property type="entry name" value="DUF863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="532" mass="61010" checksum="7909E7CEC555CD48" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGD9</accession>
    <name>A0A103XGD9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGD9"/>
    <dbReference type="STRING" id="59895.A0A103XGD9"/>
    <dbReference type="Gramene" id="KVH90173">
        <property type="protein sequence ID" value="KVH90173"/>
        <property type="gene ID" value="Ccrd_007776"/>
    </dbReference>
    <dbReference type="OMA" id="HVVCTTE"/>
    <dbReference type="OrthoDB" id="1928589at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="20073" checksum="1BE609D4D3791AF0" modified="2016-04-13" version="1">MPNPIFFASLSIPLFVIPLLYWAYTYPKNKYKQTNLVLYVHDNLTGDDASAMTVAGKDGPTTSIMHFGTLLAHDDPVTTTPDPESKHVARAQGMYINSQLDGKALYMIFSIMFTDGEYKGSTLEIQGADPFVLKEREFSVVSGTGYFRFVKGYGIMTTEFLDIPNLRAIIKLNITVRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGF7</accession>
    <name>A0A103XGF7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxyproline O-arabinosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGF7"/>
    <dbReference type="STRING" id="59895.A0A103XGF7"/>
    <dbReference type="Gramene" id="KVH90270">
        <property type="protein sequence ID" value="KVH90270"/>
        <property type="gene ID" value="Ccrd_007739"/>
    </dbReference>
    <dbReference type="OMA" id="TEIGNTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056508">
        <property type="entry name" value="HPAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF3">
        <property type="entry name" value="HYDROXYPROLINE O-ARABINOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23452">
        <property type="entry name" value="HPAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="8">
        <location>
            <begin position="267"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="379" mass="42903" checksum="772D4A70C46C4760" modified="2016-04-13" version="1" fragment="single">GVWSGQPFLYSSTTRAYLYGLQPKHIRLFSSSSSSSSPPLFPPTSLLPNSQKFPKFLHVKRFKNIEFWIMGCGNFFFTLIITFSVALITYNIIISANAPLRQELPGSSQGVLSVDPIIKMPGDRKSASASKKRLFHTAVTASDSVYNTWQTRIMYYWFKKMKKNGGVNCEMGGFTRILHSGKADKFMDEIPTFVAQPLPPGTDQGYIVLNRPWAFVQWLQQAEIKEDYILMSEPDHVIVKPIPNLSRDGLGAAFPFFYIEPKKYESESLKKIAPTWMNVSLAMKKDHEADKAFGWVLEMYAYAVSSAFHGVGNILHKDFMLQGKLTYGKIGEWRFDKRSFDTFYPPRNLPLPPPGVPESVVTLVKMVNEATENIPNWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGV0</accession>
    <name>A0A103XGV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
            <ecNumber evidence="6">2.7.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGV0"/>
    <dbReference type="STRING" id="59895.A0A103XGV0"/>
    <dbReference type="Gramene" id="KVH90510">
        <property type="protein sequence ID" value="KVH90510"/>
        <property type="gene ID" value="Ccrd_007552"/>
    </dbReference>
    <dbReference type="OMA" id="PPHEMAG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17302">
        <property type="entry name" value="PIPKc_AtPIP5K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017163">
        <property type="entry name" value="PIno-4-P-5_kinase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037274">
        <property type="entry name" value="PIP5K_plant_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="408"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="811" mass="91709" checksum="2BCFC5CAA5DD2688" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH93</accession>
    <name>A0A103XH93_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fantastic four family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH93"/>
    <dbReference type="STRING" id="59895.A0A103XH93"/>
    <dbReference type="Gramene" id="KVH90665">
        <property type="protein sequence ID" value="KVH90665"/>
        <property type="gene ID" value="Ccrd_007320"/>
    </dbReference>
    <dbReference type="OMA" id="QCFDAVE"/>
    <dbReference type="OrthoDB" id="676808at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021410">
        <property type="entry name" value="FAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046431">
        <property type="entry name" value="FAF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155">
        <property type="entry name" value="FANTASTIC FOUR-LIKE PROTEIN (DUF3049)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155:SF9">
        <property type="entry name" value="FANTASTIC FOUR-LIKE PROTEIN (DUF3049)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11250">
        <property type="entry name" value="FAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAF" evidence="2">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17480" checksum="38673ACCA7BA5F22" modified="2016-04-13" version="1">MLSPSASLINHKPDFNHQHYTMSLESLSICTEGLGFESFDDVEDQLETDSHEVKLGTTTTTTTTTTTKRAAAISMLGDGGKRSRITGSELPPPISSLGRSGKPWVCLKSYRENGRFILKEVRIRTHESLHASREDGRLKLKFIQFDDDDDDDVIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHF5</accession>
    <name>A0A103XHF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005088">
        <property type="protein sequence ID" value="KVH90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHF5"/>
    <dbReference type="STRING" id="59895.A0A103XHF5"/>
    <dbReference type="Gramene" id="KVH90841">
        <property type="protein sequence ID" value="KVH90841"/>
        <property type="gene ID" value="Ccrd_007103"/>
    </dbReference>
    <dbReference type="OMA" id="NQRERNQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="329" mass="35861" checksum="743B4DD8F78B1C66" modified="2016-04-13" version="1">MGMCSGKPANVAHVSSSQFMEDVGNRNRRNNSHPAKDRSGMAIFKKVSKASGDESFAIPINLKAFTLNELKAATKNFRPDSLLGEGGFGQVFKGWIDETTFAPVRPGTGLVVAVKVLKSESHQGHKEWLVKGVEPMAWATRMSIAIDVAHGLSFLHSKEPSIIYRDLKASNILLDSEFTARLSDFGLARNGPVGDNTHVSTRVVGTSGYAAPEYVATGHLTRKNDVYSFGVVLLELLSGRRAIADERAGGVEETLVEWVKPFLIDKRGVFRIMDTRLGGRYSKKGAQAVAELALKCLNNDPKHRPAMTEVVESLEQITNTPKNVPQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIM0</accession>
    <name>A0A103XIM0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005044">
        <property type="protein sequence ID" value="KVH91352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIM0"/>
    <dbReference type="STRING" id="59895.A0A103XIM0"/>
    <dbReference type="Gramene" id="KVH91352">
        <property type="protein sequence ID" value="KVH91352"/>
        <property type="gene ID" value="Ccrd_006637"/>
    </dbReference>
    <dbReference type="OMA" id="ATIDCVY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46692">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46692:SF1">
        <property type="entry name" value="NUCLEOSIDE HYDROLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="509"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="782" mass="88267" checksum="40BCAE43FDFC61F4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJG9</accession>
    <name>A0A103XJG9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004898">
        <property type="protein sequence ID" value="KVH91910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJG9"/>
    <dbReference type="STRING" id="59895.A0A103XJG9"/>
    <dbReference type="Gramene" id="KVH91910">
        <property type="protein sequence ID" value="KVH91910"/>
        <property type="gene ID" value="Ccrd_006057"/>
    </dbReference>
    <dbReference type="OMA" id="EKRWIKH"/>
    <dbReference type="OrthoDB" id="685237at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009902">
        <property type="entry name" value="DUF1442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33593:SF2">
        <property type="entry name" value="ANKYRIN REPEAT_KH DOMAIN PROTEIN (DUF1442)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33593">
        <property type="entry name" value="DUF1442 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07279">
        <property type="entry name" value="DUF1442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23338" checksum="F1A8BDD1CCFFD06C" modified="2016-04-13" version="1">MKLVWSPEMAAKAFMDTVKSCKLYQGSSAAELISAMAAGWNAKLIVETWSHGGVIATSIGLAVASTHTGGRHVCIVPDEDSRSEYSAAMAKAGLSPEVMVGEPAAVVMGLEVIDFLVVDSRKNDFVQILRAAKFGHRGAVLVCKNANSRATAEFRWRSLFEGGSRRIVRSVFLPVGRGLDIGHVAAGETGSGSSKVQTSRWIKRVDRESGEEFLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJV0</accession>
    <name>A0A103XJV0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004876">
        <property type="protein sequence ID" value="KVH92023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJV0"/>
    <dbReference type="STRING" id="59895.A0A103XJV0"/>
    <dbReference type="Gramene" id="KVH92023">
        <property type="protein sequence ID" value="KVH92023"/>
        <property type="gene ID" value="Ccrd_005951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF60">
        <property type="entry name" value="EXOSTOSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="8">
        <location>
            <begin position="66"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="742" mass="81496" checksum="47AC10BCB5382B9A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJW3</accession>
    <name>A0A103XJW3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_005901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004862">
        <property type="protein sequence ID" value="KVH92070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJW3"/>
    <dbReference type="STRING" id="59895.A0A103XJW3"/>
    <dbReference type="Gramene" id="KVH92070">
        <property type="protein sequence ID" value="KVH92070"/>
        <property type="gene ID" value="Ccrd_005901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF66">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH92070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10807" checksum="B6CA35A0A18AB30C" modified="2016-04-13" version="1">MVTVCLEAENQQRNQPRLHTLHVQPKTEQSILVIVVFGGINQQRNQIVDAVVIASILGAALVVPILQVIVIWGDERFVTLGPVCRTICFSGFILVEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL37</accession>
    <name>A0A103XL37_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_005331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004811">
        <property type="protein sequence ID" value="KVH92663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL37"/>
    <dbReference type="STRING" id="59895.A0A103XL37"/>
    <dbReference type="Gramene" id="KVH92663">
        <property type="protein sequence ID" value="KVH92663"/>
        <property type="gene ID" value="Ccrd_005331"/>
    </dbReference>
    <dbReference type="OMA" id="LEDPIEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF169">
        <property type="entry name" value="CYTOCHROME P450 85A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH92663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="35248" checksum="E54695E706CBCDE8" modified="2016-04-13" version="1">MDPEVNRFILMNEGKGFPPGYPQSMVYILGKSNIASVNGDAHKIMRGAFLSLVSPPIIRHQILPKTDAFMRTHLTNWTHQTIDIQQKTKEMAFLSSLNQIAGIGSSPLSKEFMAEFMKLARKKIVRMLEELIEDRRKSQEIHEDMLYSLMNGVDNRYKLSDEEIIDQIITILYSGFETVSTTSMMAIKYLHDHPRILEEFRVILETSRLATIVNGVLRKTTKEMELEGQLIMDKPLETENYFFVFGGGTRRCPGKELGIAEISTFLHYFVTRYRWEEVGGDEITKFPRVEAPNGLQIKVSPYRHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLX9</accession>
    <name>A0A103XLX9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_004767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004792">
        <property type="protein sequence ID" value="KVH93185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLX9"/>
    <dbReference type="Gramene" id="KVH93185">
        <property type="protein sequence ID" value="KVH93185"/>
        <property type="gene ID" value="Ccrd_004767"/>
    </dbReference>
    <dbReference type="OMA" id="MGSMSIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF103">
        <property type="entry name" value="B-BOX-TYPE ZINC FINGER, CCT DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH93185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="310" mass="33726" checksum="17C02EEFD31950C9" modified="2016-04-13" version="1">MGYNCDYCGEARSMVYCRSDAAYLCLSCDRNVHSANPLSKRHMRTLVCDVCNSQPALVRCVDEKASLCQNCDWVGHNGASLGASTHSRQTLNCYSGCPTAVELSSIWPFMSESCEQEMGSMSIADNSQEPSENDNTQDSSMPVETSDLQIENNSNDWMGSLLQDDNRSQDIYRQGKPLSSSANKISCSGTKDSEKVADDGLYDDFTMDEVDMNIENYEELFGVGHNDPKHLFAKDGIDSLFGMRETTTKDSANAVEPACSNAASVDSLMSCKTEPNPCHARQLSFSSLTGDSSGGEYQDCGASLPMGEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM37</accession>
    <name>A0A103XM37_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004780">
        <property type="protein sequence ID" value="KVH93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM37"/>
    <dbReference type="STRING" id="59895.A0A103XM37"/>
    <dbReference type="Gramene" id="KVH93321">
        <property type="protein sequence ID" value="KVH93321"/>
        <property type="gene ID" value="Ccrd_004626"/>
    </dbReference>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="272" mass="30741" checksum="FD4D2BDBA827D884" modified="2016-04-13" version="1">MEWEADEKEVKAAGAELLPDGRRGLRIRGWEIESSNRSILTSLNLQSWEEKLQTSHLPEMIFGDSSLVLKHMSSGTKIQFNAYDALVGWKKEALPPVEVPAAAQWKFRSKPFQQVILDYDYTFTTPYSGSETVETGSEADSEGNSCCLKWEECEEQINVVALASKEPILFYDEVILYEDELADNGVSLLTVKVLRVDGVLMRLRDTRILCTFSENTKPVILREICWRESTFKALASKGYPSDSASYNDPNVISQRLPIVLHKTQKLKVPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMB5</accession>
    <name>A0A103XMB5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_004635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004781">
        <property type="protein sequence ID" value="KVH93315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMB5"/>
    <dbReference type="Gramene" id="KVH93315">
        <property type="protein sequence ID" value="KVH93315"/>
        <property type="gene ID" value="Ccrd_004635"/>
    </dbReference>
    <dbReference type="OMA" id="HVLLICY"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000019">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000101">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF986">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 84A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH93315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="489" mass="54249" checksum="11E15C317F5B4234" modified="2016-04-13" version="1">MASKEDLVHVFLVTFPAQGHVNPLLRLGKLIASKGNLLVTFSATKYIGNKMKKAGAAVSGDPTPVGNRGGMIRFEFFNDGCSEDDDEEIHDLDTYLPKLEAYGKRSLTVIINHHAQNGRPVSCLINNPFVPWVSDLGEELNIPSAMLWVQSCACFSSFYHYENLLEPFPSEKQPDIEVQLPNMPVLKSDEVPTFLHPSTPYPFLKRAILGQFKNLSKTFCVLMETFQELEDDLIKYMSQICPIRPVGPLFKHPLLETSSNISGNLIKADDCLEWLDSKQPSSVVYISFGSVVNLSQEQLTEMAYGVLNSGVSFLWVMRKGDTFNGVKSGRLPEGFSEAAGDKGMVVQWSPQTQVLSHPAVSCFVTHCGWNSTMEALSSGVPVVAFPQWGDQVTDAKYLVDEWKVGIRMCRGEAENRVIGREEIGQCLKEATNGVKAAEMKRNALKWKKAAEAAVEEGGTSDRNIQEFVDDIMKIRRSTKTPVDQLQTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XML4</accession>
    <name>A0A103XML4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NIF system FeS cluster assembly, NifU, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_004422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004753">
        <property type="protein sequence ID" value="KVH93527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XML4"/>
    <dbReference type="STRING" id="59895.A0A103XML4"/>
    <dbReference type="Gramene" id="KVH93527">
        <property type="protein sequence ID" value="KVH93527"/>
        <property type="gene ID" value="Ccrd_004422"/>
    </dbReference>
    <dbReference type="OMA" id="PWSATHT"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000003">
        <property type="entry name" value="NifU-like protein 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000006">
        <property type="entry name" value="NifU-like protein 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF39">
        <property type="entry name" value="NIFU-LIKE PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH93527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="230" mass="24859" checksum="99864CAFD61D29B1" modified="2016-04-13" version="1">MQTAAVIFSRPQQTLDNSSSLPSSTSYSTINPFLKITSGFLGTRISHATRGSGSSKIRFPRREVVKAVTTPESVVELPLTAENIEMVLDEIRPYLIADGGNVALHEIDGNVVRLKLQGACGSCPSSVTTMKMGIERRLMEKIPEIVAVEPIPDEETGLELNEENIEKVLEEIRPYLVGAAGGSVELVSIEEPIVKVRLTGPAASVMTVRVAVTQKLREKIPAIAAVQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQH4</accession>
    <name>A0A103XQH4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha, a beta and a gamma subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004438">
        <property type="protein sequence ID" value="KVH95025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQH4"/>
    <dbReference type="STRING" id="59895.A0A103XQH4"/>
    <dbReference type="Gramene" id="KVH95025">
        <property type="protein sequence ID" value="KVH95025"/>
        <property type="gene ID" value="Ccrd_002906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF34">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF2_IF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="250" mass="28898" checksum="CBD8EB7383364639" modified="2016-04-13" version="1" fragment="single">MAEQTSSESKDDIPEVSHRLYAYASDCDLEKYDGQFLLPPLIPQRKRRRKRCKFFCDVVGHAGEDEEDANNSEPKYPWEGTDRDYFYEELLSRVFHILRENNPELAGDRRRTVIRPPQVLREGTKKTVFVNFMDLCRTMHRQPDHVMTFLLAEMGTSGSLDGQQRLVVKGRFAPKNFEGILRRYISKSCSLLLLPKQRFLHNPLCMNMSYAMAAEVRIQFFQRRICGSGRSVAPIKTGFVARVGRRKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSS6</accession>
    <name>A0A103XSS6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004347">
        <property type="protein sequence ID" value="KVH96215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSS6"/>
    <dbReference type="STRING" id="59895.A0A103XSS6"/>
    <dbReference type="Gramene" id="KVH96215">
        <property type="protein sequence ID" value="KVH96215"/>
        <property type="gene ID" value="Ccrd_001702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="22130" checksum="4BE6EBFDC0BAFA41" modified="2016-04-13" version="1">MALEWVVLGYAAAAEAVMVLLLTVPGLGPLRKGLVAVIRNLLKPFLSIVPFCLFLFMDIYWKYENRPSCASDSCTPTEHLRHQKSIMKSQRNMLLIVSALPVSSATERSMPPEITWHVPLRLDASELLYFDLLMERSITKVKVYTKQFFLRALMSQADWLKFFATGYRVSVVHIATKYNPCIFGQLNTRLSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XT52</accession>
    <name>A0A103XT52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004308">
        <property type="protein sequence ID" value="KVH96438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XT52"/>
    <dbReference type="STRING" id="59895.A0A103XT52"/>
    <dbReference type="Gramene" id="KVH96438">
        <property type="protein sequence ID" value="KVH96438"/>
        <property type="gene ID" value="Ccrd_001476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000033">
        <property type="entry name" value="Copper-transporting ATPase HMA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF2">
        <property type="entry name" value="COPPER-TRANSPORTING ATPASE HMA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="4">
        <location>
            <begin position="418"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="4">
        <location>
            <begin position="493"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="552" mass="62394" checksum="7AD0A54AC6E3CDCE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTW1</accession>
    <name>A0A103XTW1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PC-Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_001131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004192">
        <property type="protein sequence ID" value="KVH96779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTW1"/>
    <dbReference type="Gramene" id="KVH96779">
        <property type="protein sequence ID" value="KVH96779"/>
        <property type="gene ID" value="Ccrd_001131"/>
    </dbReference>
    <dbReference type="OMA" id="RWRPTSC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF264">
        <property type="entry name" value="PMR5 DOMAIN, PC-ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="118"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH96779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="398" mass="45058" checksum="DD0D253A5E58E4D1" modified="2016-04-13" version="1">MDFGYQNKIFYLLLLLLLELQVLVVVSLGRTQVLSLTTHGTSSNVSSSLRGRRSGSHGRGRKLVGCDLYRGRWIADNSYPLYAASSCPFISSEFDCLKHGRSDTQYLKYVWKPDSCNLPRFNGVDLLNKWRGKKVMFVGDSLSLNQWESLACLLHASVPNSKTTFQHRDVLTTLTFQNNIESGFSRLTDCITLYIQDYDVTIYLYRTPYLVDIVKQSIGRVLLLDSIQGGDAWKGMDVLVFNSWHWWTHTGNLQPYDSLSFDYIKDGSTISKDMDRLAAYYKGMTTWARWVELNVDPSKTKVFFQGISPTHYMNCYGELQPVEGSSYPAGLPEAQIVLNKVLSSIKKSVTLLDITTLSQLRKDAHPSSYSDSGVDCSHWCVPGLPDTWNQLMYASFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUD7</accession>
    <name>A0A103XUD7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_000807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003860">
        <property type="protein sequence ID" value="KVH97097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUD7"/>
    <dbReference type="STRING" id="59895.A0A103XUD7"/>
    <dbReference type="Gramene" id="KVH97097">
        <property type="protein sequence ID" value="KVH97097"/>
        <property type="gene ID" value="Ccrd_000807"/>
    </dbReference>
    <dbReference type="OMA" id="QWKSMEM"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH97097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="25892" checksum="8A2C81F87BADA4ED" modified="2016-04-13" version="1">MDQESGWEELRKEARKIEGDLDVKLSSYAKLGARVTQGGYADADTPTIGSNRSWKSMEMEIQSLLEKLLDVNDSMSRCAASAAATTSVTQKLARHRDILHEFSQEFRRIKGNISAMTEHAELLSSVRDDISEYKASGSMSPRMQILRERAAIHGSIAHMDDVITQAQTTRAALGSQRAMFGDVQGKVKQLSDKFPIVRGLIGSIRRKKSRDTLILSAVIAACTLFLIIYWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV11</accession>
    <name>A0A103XV11_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_000498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003833">
        <property type="protein sequence ID" value="KVH97393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV11"/>
    <dbReference type="Gramene" id="KVH97393">
        <property type="protein sequence ID" value="KVH97393"/>
        <property type="gene ID" value="Ccrd_000498"/>
    </dbReference>
    <dbReference type="OMA" id="GFLPKIC"/>
    <dbReference type="OrthoDB" id="783264at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35131">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35131:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH97393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="147" mass="16231" checksum="83EE61BB434DDA75" modified="2016-04-13" version="1">MATISAATAAAAILPEKMGGRDPVPIEIGARGTVGNLVMKEIEYFKKLELGRGDHDNCSRRNFFHPDKKHGGDGGGSNFWPSFGFLNVTWRRAKRKGGGGGSSGRFLPRMCTVVDVAESRHHNHHRLSKIPSFGYRNLKDDIDHFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWQ7</accession>
    <name>A0A103XWQ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17/PMP22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_023497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003803">
        <property type="protein sequence ID" value="KVH98286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWQ7"/>
    <dbReference type="STRING" id="59895.A0A103XWQ7"/>
    <dbReference type="Gramene" id="KVH98286">
        <property type="protein sequence ID" value="KVH98286"/>
        <property type="gene ID" value="Ccrd_023497"/>
    </dbReference>
    <dbReference type="OMA" id="ARTMTIY"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF88">
        <property type="entry name" value="PROTEIN SYM1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH98286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20490" checksum="BEC091F626FBF015" modified="2016-04-13" version="1">MGFLTWYLKMLDVRPIITKSVSAGLIYGAADLTAQSVTMRASDSLYLIRTLRMAVFGLLFLGPAQHVWFNFLGRILPKRDMATTFKKLIVGQLFYGPSCTAVFFTYNAFLQGESGREIALRLRRDLLPTLTGGLMYWPLCDFFTYKIIPVHLQPLINSAFSFMWTIYLTYMASLEKAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWS3</accession>
    <name>A0A103XWS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2HC zinc finger plants domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003802">
        <property type="protein sequence ID" value="KVH98312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWS3"/>
    <dbReference type="STRING" id="59895.A0A103XWS3"/>
    <dbReference type="Gramene" id="KVH98312">
        <property type="protein sequence ID" value="KVH98312"/>
        <property type="gene ID" value="Ccrd_023467"/>
    </dbReference>
    <dbReference type="OMA" id="DEHYTYW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056971">
        <property type="entry name" value="Znf-C2HC_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35513">
        <property type="entry name" value="OS02G0158600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35513:SF1">
        <property type="entry name" value="OS02G0158600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25017">
        <property type="entry name" value="zf-C2HC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2HC zinc finger plants" evidence="2">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="18354" checksum="5F71C2D988B0F453" modified="2016-04-13" version="1">MDSKDVDMMDSDAPVTSSPSDTTELSSVSDQIEVARRLLTVARQLIDQGKPSQALQAGGEAAAFQALTRAKELYRNKIHETTAADELASLFAECAIAEASPEPSTSNNTISHPFPSFESDTSGTSILAETGRKQIVLDAFSDGSSFVCLQCGGLVSNDRRDEHYAFWCGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX67</accession>
    <name>A0A103XX67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibronectin type III-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003789">
        <property type="protein sequence ID" value="KVH98568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XX67"/>
    <dbReference type="STRING" id="59895.A0A103XX67"/>
    <dbReference type="Gramene" id="KVH98568">
        <property type="protein sequence ID" value="KVH98568"/>
        <property type="gene ID" value="Ccrd_023207"/>
    </dbReference>
    <dbReference type="OMA" id="IGFWAND"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000001">
        <property type="entry name" value="probable beta-D-xylosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119192" evidence="6">
        <location>
            <begin position="24"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="7">
        <location>
            <begin position="638"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH98568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="715" mass="78079" checksum="BE3C941FED032A32" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXX3</accession>
    <name>A0A103XXX3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_022902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003643">
        <property type="protein sequence ID" value="KVH98869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXX3"/>
    <dbReference type="Gramene" id="KVH98869">
        <property type="protein sequence ID" value="KVH98869"/>
        <property type="gene ID" value="Ccrd_022902"/>
    </dbReference>
    <dbReference type="OMA" id="FMEDAYF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="21631" checksum="D4C4C5320C7B771A" modified="2016-04-13" version="1">MAMKTFLDMLQHRISPNLVTFNTLLSWHCKAGDMSEAREFLKMLLQRGFKPDTYTFSSLTHGLCRTHQIDDALDFLNEMVGWGVHPNTITYNILIFSLCIIGDVFKAKALMKKMQTNGVKPDVFSFNALIQNFCRMKKVEKAHRVLLTMLTLVLNRPSFITSIAISVDLFWKVSNSRNLARSEAGSLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYB7</accession>
    <name>A0A103XYB7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003636">
        <property type="protein sequence ID" value="KVH99141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYB7"/>
    <dbReference type="STRING" id="59895.A0A103XYB7"/>
    <dbReference type="Gramene" id="KVH99141">
        <property type="protein sequence ID" value="KVH99141"/>
        <property type="gene ID" value="Ccrd_022628"/>
    </dbReference>
    <dbReference type="OMA" id="MKMRDEV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043424">
        <property type="entry name" value="BLT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071:SF2">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PAN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="421" mass="48339" checksum="BB290921163B578C" modified="2016-04-13" version="1">MEGATKWDPGSWKASEDVRRIYGESKHLEEQVGVVAMVSALESELEQARARIHDLENERRSSKKKLEQFLKKLNEERATWRSREHEKIRAVIDDIKGELNRERKNRQRMEIVNSKLVNELADCKLSAKRYMQDYEKERKARELIEEVCDELAKEIGEDKAEVEALKRESMKMREEVDDERKMLQMAEVWREERVQMKLVDAKVTLEDKYSQMNKLVADLQDFLNSKSTNLDAEEMKRAETLKQSADSVNIQEIGDFKYEPANPDDIFSVFEEVGFGSKEIEPEPRREWEDGTPITEITEVCSVPNKQPKKASSISRLWRSSYSSNGENCKIISMEGLNGRLSNGTHLSSGAVLSPDRSSGLSPSEWSSPGSGSNPHITKGMKGCIEWPRGVMQKNSLKAKLLEARMESQKVQLRQVLKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYL7</accession>
    <name>A0A103XYL7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem II 10 kDa polypeptide, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_022542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associated with the oxygen-evolving complex of photosystem II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the psbR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003630">
        <property type="protein sequence ID" value="KVH99239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYL7"/>
    <dbReference type="STRING" id="59895.A0A103XYL7"/>
    <dbReference type="Gramene" id="KVH99239">
        <property type="protein sequence ID" value="KVH99239"/>
        <property type="gene ID" value="Ccrd_022542"/>
    </dbReference>
    <dbReference type="OMA" id="IWAPEEW"/>
    <dbReference type="OrthoDB" id="496093at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006814">
        <property type="entry name" value="PSII_PsbR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34369">
        <property type="entry name" value="PHOTOSYSTEM II 10 KDA POLYPEPTIDE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34369:SF2">
        <property type="entry name" value="PHOTOSYSTEM II 10 KDA POLYPEPTIDE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04725">
        <property type="entry name" value="PsbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH99239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="137" mass="14104" checksum="26AF61FBCD65DC24" modified="2016-04-13" version="1">MAATVMSSVTLKPSAPLVAAEVKALPSLSTRSSFRVCASGVKKIKTDKPFGIGGGMALRDGKDANGRKPTGKGVYQFVDKYGANVDGYSPIYNEEEWSPSGDVYVGGTTGLLIWAVTLAGILGGGALLVYSTSALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYP8</accession>
    <name>A0A103XYP8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase HflX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_022442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003612">
        <property type="protein sequence ID" value="KVH99328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYP8"/>
    <dbReference type="STRING" id="59895.A0A103XYP8"/>
    <dbReference type="Gramene" id="KVH99328">
        <property type="protein sequence ID" value="KVH99328"/>
        <property type="gene ID" value="Ccrd_022442"/>
    </dbReference>
    <dbReference type="OMA" id="VEHRKRY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11060:FF:000006">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045498">
        <property type="entry name" value="HflX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19275">
        <property type="entry name" value="HflX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="363"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH99328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="575" mass="64753" checksum="BAD5BDCC3F2121F1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZN8</accession>
    <name>A0A103XZN8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein TIFY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Jasmonate ZIM domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Repressor of jasmonate responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The jas domain is required for interaction with COI1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TIFY/JAZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003412">
        <property type="protein sequence ID" value="KVH99842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZN8"/>
    <dbReference type="STRING" id="59895.A0A103XZN8"/>
    <dbReference type="Gramene" id="KVH99842">
        <property type="protein sequence ID" value="KVH99842"/>
        <property type="gene ID" value="Ccrd_021917"/>
    </dbReference>
    <dbReference type="OMA" id="PTSKWER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040390">
        <property type="entry name" value="TIFY/JAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010399">
        <property type="entry name" value="Tify_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077">
        <property type="entry name" value="PROTEIN TIFY 4A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077:SF8">
        <property type="entry name" value="PROTEIN TIFY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06200">
        <property type="entry name" value="tify"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00979">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51320">
        <property type="entry name" value="TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1184">Jasmonic acid signaling pathway</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tify" evidence="4">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="40559" checksum="074F1EC2E8A4E16F" modified="2016-04-13" version="1">MAAVLFSSTMSQNTTTNVNDDVKPTIFHDFLGRQCAPLLHCAAADGGSPSPSASRAGGAPISTTSDLDSDRQVGSHLEGVPFYGQRNDFSPSEIRNRYAGSKRSNSDYVFMGSSRDGVPQIRPDFPENSHLMKVLSNIGQQEQLKRPHEVEAFMAAHPIRPTSKWERAIPVNVGPLLQYPPRAGQAVPNAYQTLSNRFKDANVGSVISQSAADQGSRTGIKGSGILSSSINVNGGVAEPAIGKQKSVISVPEPGSSSPLRRQMTIFYGGQAHVFDDVHPNKADAIMALAGSTGASWSTSYSNSVVKPARPSGENIPVTGENTGMAASNSGLPRGRFYVAGSSSPGAVSNDRRSMPHGGHGGVLMADPRQRTTRAAVESSTEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y093</accession>
    <name>A0A103Y093_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wall-associated receptor kinase galacturonan-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_021630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003398">
        <property type="protein sequence ID" value="KVI00145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y093"/>
    <dbReference type="STRING" id="59895.A0A103Y093"/>
    <dbReference type="Gramene" id="KVI00145">
        <property type="protein sequence ID" value="KVI00145"/>
        <property type="gene ID" value="Ccrd_021630"/>
    </dbReference>
    <dbReference type="OMA" id="VITHETI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI00145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27518" checksum="81DD9C0C4A263A33" modified="2016-04-13" version="1">MLEGSSESLQVPPRRFWSSSPTRLAQGGQFNLVPYPFGFSSGCQVQLNCTSNGTVFINEFPIQEITPDGLLVNLPTMCGRAVDTISHLYGEHYAPTSTNNILMENCKEKKMSNCAIPMRIVRTQLQITNCSGVRDGYDGNVSCYSGDSTRMFFDYENVTRMGCRFLFSGVVLSEEIGDNLVSVDIQVFKLGWWLKGTCDCSGDADCTKIVSPSDGSDGHRCTCKSGFVGDGYKAGSSCRKVEGMSSIRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2E2</accession>
    <name>A0A103Y2E2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003122">
        <property type="protein sequence ID" value="KVI01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2E2"/>
    <dbReference type="STRING" id="59895.A0A103Y2E2"/>
    <dbReference type="Gramene" id="KVI01269">
        <property type="protein sequence ID" value="KVI01269"/>
        <property type="gene ID" value="Ccrd_020454"/>
    </dbReference>
    <dbReference type="OMA" id="APMANVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044820">
        <property type="entry name" value="AGD14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085:SF3">
        <property type="entry name" value="ARF GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085">
        <property type="entry name" value="ARFGAP/RECO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="591" mass="63375" checksum="15673E6D869FDF75" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3M9</accession>
    <name>A0A103Y3M9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002672">
        <property type="protein sequence ID" value="KVI01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3M9"/>
    <dbReference type="STRING" id="59895.A0A103Y3M9"/>
    <dbReference type="Gramene" id="KVI01917">
        <property type="protein sequence ID" value="KVI01917"/>
        <property type="gene ID" value="Ccrd_019808"/>
    </dbReference>
    <dbReference type="OMA" id="QNNLRMG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35712">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35712:SF1">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="659" mass="74932" checksum="FB425AEE48F77B3B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4F2</accession>
    <name>A0A103Y4F2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002656">
        <property type="protein sequence ID" value="KVI02329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4F2"/>
    <dbReference type="STRING" id="59895.A0A103Y4F2"/>
    <dbReference type="Gramene" id="KVI02329">
        <property type="protein sequence ID" value="KVI02329"/>
        <property type="gene ID" value="Ccrd_019388"/>
    </dbReference>
    <dbReference type="OMA" id="TICTWAR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000003">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF2">
        <property type="entry name" value="METAL TOLERANCE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="159"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="367"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="51043" checksum="90C2045457269EBB" modified="2016-04-13" version="1" fragment="single">SFHFHISRTHLYLSLSLSIYIYAHIFLDQNFYKKIIKLMEGGSDITGGGGGLYEEDDDNIILSPPPHQPSSWRLNINHFHLPQTSSYSNPTSKSTSTFRRLFRPTPRKHGKVQEYYKKQKRLLEGFNEMETMNESGCLPGSLTEDEMDNLAKNEKRAIYVSNMANLVLFIAKVYASIESRSLAVIASTLDSLLDLLSGFILWFTSHAMRNPNQYHYPIGKNRMQPVGIIVFASVMATLGFQILLESARQLIAKTRPDMNHDNENWVIGIMASVTVVKFMLMIYCRRFKNEIVRAYAQDHLFDVVTNSVGLASTILAVRYEWWIDPVGAIIIAVYTICTWARTVIENVWSLIGRTAPPDFLAKLTYLVWNHHEEIKHIDTVRAYTFGSHYFVEVDIVLPEDMLLNQAHNIGEMLQEKLEQLPQVERAFVHIDFEFSHRPEHKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4L0</accession>
    <name>A0A103Y4L0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002653">
        <property type="protein sequence ID" value="KVI02419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4L0"/>
    <dbReference type="STRING" id="59895.A0A103Y4L0"/>
    <dbReference type="Gramene" id="KVI02419">
        <property type="protein sequence ID" value="KVI02419"/>
        <property type="gene ID" value="Ccrd_019293"/>
    </dbReference>
    <dbReference type="OMA" id="TESWGTY"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000028">
        <property type="entry name" value="Glutaredoxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="13597" checksum="2146CEB48D1B960E" modified="2016-04-13" version="1">MHYQQSESWATYMPTATSCQLLERIERLASENAVVIFSVSSCCMCHAIKRLFCGMGVNPTVYELDQEPFGKDMEKALMRLLGTSSPVPVVFVGGKLVGAMDRVMASHINGSLVPLLKEAGALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5A6</accession>
    <name>A0A103Y5A6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Multi antimicrobial extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002630">
        <property type="protein sequence ID" value="KVI02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5A6"/>
    <dbReference type="STRING" id="59895.A0A103Y5A6"/>
    <dbReference type="Gramene" id="KVI02785">
        <property type="protein sequence ID" value="KVI02785"/>
        <property type="gene ID" value="Ccrd_018925"/>
    </dbReference>
    <dbReference type="OMA" id="YTCSAII"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41016" checksum="C6B856E6EA420AC9" modified="2016-04-13" version="1" fragment="single">MSVIAAPMVVVAVLQYLMQLVAVVMVGHIDEIALSSVAIATSLTNVTGFSLLSGLVGGLETLCGQAFGAKQYNKIGVYTCSAIISLLLVCIPVSISWIFLDKFLILIGQDPLISIQARKFSIYLIPALFAGAILKPLVRSLQTQSLTRPLLVSSALALCINVPLCWAFVFKFKMGSVGAAIAFSVSNWLYLMLIVFHIKFSISCENTRVTLSMNAIVGIKEFFRFGIPSAPQMVVARSACLDLRFVTKSKARNLGPFYMVYFPRLAVRVVMLVIITEATIVSTAVFGCRHFLGKAYSNDKPVVSYVASMAPGWQHIGAYVNLGAFYLFGIPAAVGLGFPLHLKAKGLWIGIVIGSVIQSTSLSLITGLTDWRKQVRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5B4</accession>
    <name>A0A103Y5B4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_018942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002637">
        <property type="protein sequence ID" value="KVI02769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI02769">
        <property type="protein sequence ID" value="KVI02769"/>
        <property type="gene ID" value="Ccrd_018942"/>
    </dbReference>
    <dbReference type="OMA" id="NTHGRIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="230" mass="25351" checksum="EBCB613C03FA7ACD" modified="2016-04-13" version="1">MAAPAMVRNMQVLFKNYIDGFPKESDMVVSSDATISLKLPKNESGVVLTKNLYLSCDPMMRNRMTESYLGAYMESFXPGSPLVGVGVSKVLDSTHPDFKKGDYVSGFTNWEEYSVVKNPQLTKIQHTDVSLSYYTGILGMAGMTAYVGFYEICAAKKGEYFFVSAASGAVGQLVGQFAKRAGCYVVGSAGSKEKVDLLKNKFGFDEAFNYKEEQDLTAXLKRCLMQYLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y713</accession>
    <name>A0A103Y713_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_017984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y713"/>
    <dbReference type="Gramene" id="KVI03694">
        <property type="protein sequence ID" value="KVI03694"/>
        <property type="gene ID" value="Ccrd_017984"/>
    </dbReference>
    <dbReference type="OMA" id="AIQNFPF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119461" evidence="7">
        <location>
            <begin position="20"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="9">
        <location>
            <begin position="314"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="54324" checksum="8F96D9EDA070C003" modified="2016-04-13" version="1" fragment="single">MALQWLSLVGIIWLQSISATNSNFPAYSSQLKLLLSLSQLQLNNLAFASDAGKLFGFFSGMAAVYLPLWLVLLIGSALGFIGYGVQYLFLLTNNISALPYSLVFLLTVLAGNSICWINTVCYVIAIENFPLDRQLAVGLSTSYQGLSAKIYSDVVDVVFKSPSSSSSRADQRARSYLLLNSMVPLVVCLIASPLVRVINTARSKRLSGGFLVIFAITIFTGTYAVITSLGSRNKRLSPPLMILIGMCVFLMAPLVVPLMEKIRENMEHKCLIRSYGKKICDESSMDDQEDGEKNGGVETEQVVKDEGVLVNDDEEMGVKVMVKRLNFWLYFFVYMFGATVGMVYLNNLGQIAESRGGSNTSSLVSLASSFGFFGRLFPCLLDYHLFRAKYKVSRPALIALMMVPMTLAFFLLLNSSNICLHISTATIGICTGAITSISVSTTAELFGTKNFGVNHNIVVTNIPIGSFLFGDMAALLYREQGLANGDGKCMGIKCYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y976</accession>
    <name>A0A103Y976_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_016854</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RLP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001906">
        <property type="protein sequence ID" value="KVI04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y976"/>
    <dbReference type="Gramene" id="KVI04823">
        <property type="protein sequence ID" value="KVI04823"/>
        <property type="gene ID" value="Ccrd_016854"/>
    </dbReference>
    <dbReference type="OMA" id="NENMVHG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="687"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="978" mass="105544" checksum="8BA546EB66CF6BD6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y978</accession>
    <name>A0A103Y978_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001907">
        <property type="protein sequence ID" value="KVI04810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y978"/>
    <dbReference type="STRING" id="59895.A0A103Y978"/>
    <dbReference type="Gramene" id="KVI04810">
        <property type="protein sequence ID" value="KVI04810"/>
        <property type="gene ID" value="Ccrd_016867"/>
    </dbReference>
    <dbReference type="OMA" id="PAYHHIL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF6">
        <property type="entry name" value="POTASSIUM TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="27"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="322"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="428"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="673" mass="75491" checksum="4262F9646CC6B31B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y982</accession>
    <name>A0A103Y982_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001905">
        <property type="protein sequence ID" value="KVI04856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y982"/>
    <dbReference type="STRING" id="59895.A0A103Y982"/>
    <dbReference type="Gramene" id="KVI04856">
        <property type="protein sequence ID" value="KVI04856"/>
        <property type="gene ID" value="Ccrd_016828"/>
    </dbReference>
    <dbReference type="OMA" id="NSVMGHI"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="140"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="438" mass="49931" checksum="8C46745888403625" modified="2016-04-13" version="1">MATWVLSECGLRPLPRLYPNPTTRTSTSSFPSSITIPANKIFRPNSLVTRGRSWAVKVSAPVGIQFVDEDEKRVDEPKVGESEFNPGAPPPFSLADIRAAIPKHCWVKDPWKSMSYVLRDVVVVFGLAAVAAYFNNMVVWPLYWLAQGTMFWALFVLGHDCGHGSFSNNAKLNSVVGHLLHSSILVPYHGWRISHRTHHQNHGHVENDESWHPLSEKIYRSLDTATRMLRFTLPFPMLAYPFYLWGRSPGKKGSHFHPGSDLFLPNEKKDVITSTVCWTAMAALLVGLSFVMGPLQVFKLYGIPYWGFVMWLDLVTYLHHHGHEDKLPWYRGKEWSYLRGGLTTLDRDYGWINNIHHDIGTHVIHHLFPQIPHYNLIEATEAAKPVLGKYYREPKKSWPLPLHLLGLLANSMKKDHYVSDEGDVVYYQTDSKLTGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9D2</accession>
    <name>A0A103Y9D2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001898">
        <property type="protein sequence ID" value="KVI04941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9D2"/>
    <dbReference type="Gramene" id="KVI04941">
        <property type="protein sequence ID" value="KVI04941"/>
        <property type="gene ID" value="Ccrd_016731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI04941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15746" checksum="3BC25159CCADF3D6" modified="2016-04-13" version="1">MKNQGSISIQTYYAASVCSAFNNIKPHLTRICCLQLHLDSVQLSLEPVLGARVNHLAPHFCGLLLPCNEENPALWDIFCSHKIKIKDSISALISRETCCKFIVSLCWFPKLFHNHLLLLLFDFINDEAKGPLCLQIHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9G9</accession>
    <name>A0A103Y9G9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_016727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001898">
        <property type="protein sequence ID" value="KVI04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9G9"/>
    <dbReference type="STRING" id="59895.A0A103Y9G9"/>
    <dbReference type="Gramene" id="KVI04945">
        <property type="protein sequence ID" value="KVI04945"/>
        <property type="gene ID" value="Ccrd_016727"/>
    </dbReference>
    <dbReference type="OMA" id="INGPMLN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="351" mass="37862" checksum="67DA6B604AC48E90" modified="2016-04-13" version="1">MMLEKMKPYFAVIFLQFGNAGLVIIAKAALNHGMNHYTFAVYRNLIATLVITPFALFFESKGRPKLTISIFFKIMLLGFLEPVVDQNLYYAGMKYTTATFAIVGTLVTVGGAMIMTVVAGPTIGLPWTKGSTTDHQQQSTTPPVSPADNIKGSMMIIAGCVSWSFFYIVQAITLRSYPAELSLTALICAAGTMQGSIVTIIAERGNNEAWRLHLDAGLVTMVYGGVICSGLGYYLSGIIMKEKGPVFVTAFNPLSMVIVAVLGSIVLSEQMNLGRVLGAAVIVIGLYLVIWGKSKDESQSNSKCDPDQLPPVNQQQIPMTISSTKLAKEDQDSLSIAIPPTNETVVKINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9S6</accession>
    <name>A0A103Y9S6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_016505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9S6"/>
    <dbReference type="STRING" id="59895.A0A103Y9S6"/>
    <dbReference type="Gramene" id="KVI05150">
        <property type="protein sequence ID" value="KVI05150"/>
        <property type="gene ID" value="Ccrd_016505"/>
    </dbReference>
    <dbReference type="OMA" id="DLSCKFC"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000005">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000003">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119518" description="glucan endo-1,3-beta-D-glucosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="369"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI05150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="457" mass="49586" checksum="EE5F0C1462C863D1" modified="2016-04-13" version="1">MALLSLLPILLLLPFPTVSAVGINYGTLGNNLPPPKKVAQLLQATLIDKVKIYDTNPQILQAFSNSGIDVIVAVENNHVANISSTKSVAEDWFSARIAPFIPATSIVAIAVGNEYLATDDDDMDPNSLIQAMQNLHEVLLSRGLDRKIKITTPHSMAVLATSFPPSASTFATTLMPTMTSIVAFLADTGSPFMVNAYPYFAYRDNPTTVSLEYALFGNATGVHDPKGYVYTNMLDAQIDAIRSAIVSLGFGNRSVHITVSESGWPSKGEPGESAASPDNARTYNSRLITKAQSNKGTPMKPNDKIDIFLFALFNENKKEGGSSERNFGLFNGDGSKVYDADLRCEFCSGSKMDFGFESGSKMVQRGPSVWCVAKPHAEERVVQGVLDFCCGPGGVDCRDVYENGPCFGPNKVHAHASYAMNAYYQMHGRNYWNCDFKGSGLVTFSDPSYGTCKYSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YA47</accession>
    <name>A0A103YA47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DFDF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_016341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LSM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001878">
        <property type="protein sequence ID" value="KVI05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YA47"/>
    <dbReference type="STRING" id="59895.A0A103YA47"/>
    <dbReference type="Gramene" id="KVI05321">
        <property type="protein sequence ID" value="KVI05321"/>
        <property type="gene ID" value="Ccrd_016341"/>
    </dbReference>
    <dbReference type="OMA" id="SRHRGGW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000033">
        <property type="entry name" value="Trailer hitch, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="10">
        <location>
            <begin position="450"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="11">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="12">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="7">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="8">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="603" mass="64448" checksum="3AFAA52430266430" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAA1</accession>
    <name>A0A103YAA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_016256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001873">
        <property type="protein sequence ID" value="KVI05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAA1"/>
    <dbReference type="STRING" id="59895.A0A103YAA1"/>
    <dbReference type="Gramene" id="KVI05395">
        <property type="protein sequence ID" value="KVI05395"/>
        <property type="gene ID" value="Ccrd_016256"/>
    </dbReference>
    <dbReference type="OMA" id="NAFICEW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33782:SF5">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33782">
        <property type="entry name" value="OS01G0121600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="265" mass="30087" checksum="9ED35E3B5E73FB4D" modified="2016-04-13" version="1">MQTSSFYHRLTPPGAPFSGVVCQTRRPFNNDHNRLPTMAFKKDGSNGKMVDENMIVLRERIRKMKAEMDGGSGDDWLPDNWMEWEKTYTYSGGYHSDVYEMIALLQRFLMESRPSVGLGLVAVLAFSGSTSAAMVLRWLIITRKTQPYIFRPTRLSVSAAKGDAMGGRMVDENMIVLRKRIHEMKVEERSYEPPSEWMDWEKKYYVSYNAFICEWMRVLQSGLMNTRPSLALGMMVLIASSVPVSSFVVVSNAIEIGKGVLNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAF5</accession>
    <name>A0A103YAF5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rubisco LS methyltransferase, substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_016207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001871">
        <property type="protein sequence ID" value="KVI05442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAF5"/>
    <dbReference type="STRING" id="59895.A0A103YAF5"/>
    <dbReference type="Gramene" id="KVI05442">
        <property type="protein sequence ID" value="KVI05442"/>
        <property type="gene ID" value="Ccrd_016207"/>
    </dbReference>
    <dbReference type="OMA" id="PHPPDLI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000009">
        <property type="entry name" value="Histone-lysine N-methyltransferase setd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1420.10:FF:000007">
        <property type="entry name" value="SET domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF116">
        <property type="entry name" value="F21J9.27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="68"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI05442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="515" mass="56968" checksum="C3DCD13F3270AD04" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB61</accession>
    <name>A0A103YB61_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001860">
        <property type="protein sequence ID" value="KVI05869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YB61"/>
    <dbReference type="Gramene" id="KVI05869">
        <property type="protein sequence ID" value="KVI05869"/>
        <property type="gene ID" value="Ccrd_015791"/>
    </dbReference>
    <dbReference type="OMA" id="GPTIMQT"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF8">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="253"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="38921" checksum="62FE73678399B2B1" modified="2016-04-13" version="1">MNLSTVEEESSDQNVHTPTEIDWHMLDKSKFFFLGAGLFSCVSATLYPVVVLKTRQQVSSSHLSSLRTAFSILRYEGLRGLYRGFGTSLIGTIPARALYMTALEVTKSNVGSTTVRLGFPEPTASAIANAMAGLSAALAAQLVWTPVDVVSQRLMVQGNDYSNSKISSSLKSCKYMNGIDAFRKILNTDGPRGLYRGFGISIMTYAPSNAVWWASYSVTQRLVWDGIGSYMCKKDDENNENGGVVALRPDSRTVMAVQGVSAAMAGGVSALVTMPLDTIKTRLQVLDCSDDNNNNNGRKGPTVGQTVRNLVKEGGWMAFYRGLGPRWASMSLSATTMITTYELLKRLSTKNQENLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDA5</accession>
    <name>A0A103YDA5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001534">
        <property type="protein sequence ID" value="KVI06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDA5"/>
    <dbReference type="STRING" id="59895.A0A103YDA5"/>
    <dbReference type="Gramene" id="KVI06985">
        <property type="protein sequence ID" value="KVI06985"/>
        <property type="gene ID" value="Ccrd_014660"/>
    </dbReference>
    <dbReference type="OMA" id="IVYPANL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="240"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="338" mass="36724" checksum="6730025BF30EBFC5" modified="2016-04-13" version="1">MQTEATVGVVEGGGPARKLVAHHQRPVQHQQSQVGTVSQLIAGGVAGAVSKTCTAPLARLTILFQVQGMHSDASTLRKASLWREASRIVSEEGFRAFWKGNLVTIAHRLPYSSISFYAFERYKNVGTNLLQLITGVDSHGTNISAGLFIRLAGGGLAGITAASVTYPLDLVRTRLSAQRNVIYYRGIWHALRTISREEGIFGLYKGLGACLLGVGPNLAISFSVYDTARSYWQLQRPEDSAVLVSLACGSLSGIASSTVTFPLDLVRRRMQLEGAGGRARVYKTGIFGTFGQIIRAEGIRGIYRGILPEYYKVVPSIGIVFMTYEKLKQVLSNIDPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDQ4</accession>
    <name>A0A103YDQ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_014440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001510">
        <property type="protein sequence ID" value="KVI07204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDQ4"/>
    <dbReference type="STRING" id="59895.A0A103YDQ4"/>
    <dbReference type="Gramene" id="KVI07204">
        <property type="protein sequence ID" value="KVI07204"/>
        <property type="gene ID" value="Ccrd_014440"/>
    </dbReference>
    <dbReference type="OMA" id="TEGHYNL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000012">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000023">
        <property type="entry name" value="Monocopper oxidase-like protein SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF270">
        <property type="entry name" value="MONOCOPPER OXIDASE-LIKE PROTEIN SKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="71"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="196"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="378"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="513" mass="57576" checksum="4EA808EF8041FF8D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YER2</accession>
    <name>A0A103YER2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_013889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001492">
        <property type="protein sequence ID" value="KVI07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YER2"/>
    <dbReference type="STRING" id="59895.A0A103YER2"/>
    <dbReference type="Gramene" id="KVI07748">
        <property type="protein sequence ID" value="KVI07748"/>
        <property type="gene ID" value="Ccrd_013889"/>
    </dbReference>
    <dbReference type="OMA" id="FVASGWE"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.760:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015217404" description="Expansin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="8">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="9">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="27578" checksum="390B09DDC576625F" modified="2016-04-13" version="1">MVKLTTILLLASFSYLLVHVHGFTASRWIKAHATFYGGSDASGTMGGACGYGNLYSTGYGTRTAALSTALFKQGAACGQCYKIICDHKADSRWCKKGVSVTVTATNFCPPNYAQGNNAGGWCNPPLQHFDMAQPAWEKIGIYKGGIVPVIFQRVPCKKHGGVRFTVNGRNYFELVLITNVGGAGSIRSVRVKGSRTGWTPMSSNWGANWQSNAYLNGQSMSFMITTTDGVTKTFSNVVPSNWRFGQTYSSRVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEY3</accession>
    <name>A0A103YEY3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001483">
        <property type="protein sequence ID" value="KVI07840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEY3"/>
    <dbReference type="STRING" id="59895.A0A103YEY3"/>
    <dbReference type="Gramene" id="KVI07840">
        <property type="protein sequence ID" value="KVI07840"/>
        <property type="gene ID" value="Ccrd_013802"/>
    </dbReference>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="327" mass="36405" checksum="F645535D3EC49ABE" modified="2016-04-13" version="1">MSRLSGNLLRTVLRRRSFCTADNIDGNLQSSKVQIFDRHLKRKQRDRAAWLINRKDSLVNTVADNLLDRLEDVKKSFPTTLCLGGSLEAIRRSVRGRGGIQRLVMMDSSHDMVKLCKDAEKDFSSDNIETSYIVGDEEYLPIQGSSVDLVISCLGLHWTNDLPGAMIQSRMALKPDGLFLAAIFGGETLKELRIACTIAHMEREGGVSPRVSPLAQVRDAGNLLTRAGFTLPGVDVDEYQVRYNSALELIEHLRAMGETNALFLKKDTALATAAVYESMFAAEDGTIPATFQVIYMTGWREHESQQKAKRRGSATVSFQDIQKEFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFV1</accession>
    <name>A0A103YFV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001146">
        <property type="protein sequence ID" value="KVI08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFV1"/>
    <dbReference type="STRING" id="59895.A0A103YFV1"/>
    <dbReference type="Gramene" id="KVI08290">
        <property type="protein sequence ID" value="KVI08290"/>
        <property type="gene ID" value="Ccrd_013340"/>
    </dbReference>
    <dbReference type="OMA" id="QLLCWCH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="216" mass="24154" checksum="3D0D0D3BF6AF7AAC" modified="2016-04-13" version="1">MGGRSYSPSPPRGGHGRRGRSPSPRGRYGGGGGGGGGGGRGRDLPTSLLVRNLRHDCRGGSGRPSDRRRSPPPRYSRSPPRYSRSPPPRYTRSRSHSREYSPPPKRKQHVRSISPREKRHSRERSYSQSPVKERSPPYDGPPRSRSRSPVMERSPPYNGSRSPSRSPARERVPPRGDRSPVRERRAARDPSRSRSRSPIPRDYSRSEADRDASPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGZ6</accession>
    <name>A0A103YGZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribulose bisphosphate carboxylase, large subunit, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexadecamer of 8 large chains and 8 small chains; disulfide-linked. The disulfide link is formed within the large subunit homodimers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001079">
        <property type="protein sequence ID" value="KVI08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGZ6"/>
    <dbReference type="STRING" id="59895.A0A103YGZ6"/>
    <dbReference type="Gramene" id="KVI08905">
        <property type="protein sequence ID" value="KVI08905"/>
        <property type="gene ID" value="Ccrd_012716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="entry name" value="Ribulose bisphosphate carboxylase, large subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704:SF17">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="RuBisCo, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribulose bisphosphate carboxylase large subunit C-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="9118" checksum="3975B4022D49DEB4" modified="2016-04-13" version="1">MKKKCEVETIEITESNGANEKLPQKLKHSEIKWHYLNVTAGTYKEMMKRAIFARELGVPVVMHDYLTGGFSANTSLAHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHA7</accession>
    <name>A0A103YHA7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_012543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHA7"/>
    <dbReference type="STRING" id="59895.A0A103YHA7"/>
    <dbReference type="Gramene" id="KVI09084">
        <property type="protein sequence ID" value="KVI09084"/>
        <property type="gene ID" value="Ccrd_012543"/>
    </dbReference>
    <dbReference type="OMA" id="WIVDIGW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF6">
        <property type="entry name" value="PROTEIN YIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="112"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="38040" checksum="35A81BD657DD80BE" modified="2016-04-13" version="1">MMSGNYTSIQNQNASGSVPPAPDPPGQVSVKFNESTLQTFPPSAPQGKIAGGSGPPRDADDTFSKPSSGSSEQPSAGWLKVFTIAAYQPYFDVDTSDILERIKDSFLPFRGTFNEKTASNPDLYGPFWICTTLIFVSAAIGTFAAYLAHRISHKDWDYDIRLLTWSASLLYAYAVFVPISLYIILKYLSAPLGLIQLVCLYGYSLFIFIPAVFLSMIPVEMFRWVVAGVAGFMSAMFVASNLRTHIVSAGEKWFWIVAGIFLLQLGLSIVLELYLFSSSIFELIPLGQDTDTMGILGGFISIPNDTYLFHGGGAHWLEVKRMVPVELLHGKVSLDLILSDLWIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHN4</accession>
    <name>A0A103YHN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001068">
        <property type="protein sequence ID" value="KVI09279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHN4"/>
    <dbReference type="STRING" id="59895.A0A103YHN4"/>
    <dbReference type="Gramene" id="KVI09279">
        <property type="protein sequence ID" value="KVI09279"/>
        <property type="gene ID" value="Ccrd_012419"/>
    </dbReference>
    <dbReference type="OMA" id="LQVWKHM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053343">
        <property type="entry name" value="PSII_mRNA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47940">
        <property type="entry name" value="OS12G0283900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47940:SF1">
        <property type="entry name" value="PROTEIN LOW PHOTOSYNTHETIC EFFICIENCY 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="491"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="724" mass="81557" checksum="29BB39AE06AE4656" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIK3</accession>
    <name>A0A103YIK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_011930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001047">
        <property type="protein sequence ID" value="KVI09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIK3"/>
    <dbReference type="STRING" id="59895.A0A103YIK3"/>
    <dbReference type="Gramene" id="KVI09682">
        <property type="protein sequence ID" value="KVI09682"/>
        <property type="gene ID" value="Ccrd_011930"/>
    </dbReference>
    <dbReference type="OMA" id="EDHQREY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF776">
        <property type="entry name" value="AGAMOUS-LIKE 50-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="9820" checksum="11526CF174BCE488" modified="2016-04-13" version="1">MTPSKKTKGRQKIEMTKILDEKSLAVTFSKRHSGILSKANELSTLCGVELAIIMLSPTKKPVSYGVPSVEAILDRYMEQLPPPDLSMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK50</accession>
    <name>A0A103YK50_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein FLX-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_011051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FLX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001014">
        <property type="protein sequence ID" value="KVI10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK50"/>
    <dbReference type="STRING" id="59895.A0A103YK50"/>
    <dbReference type="Gramene" id="KVI10538">
        <property type="protein sequence ID" value="KVI10538"/>
        <property type="gene ID" value="Ccrd_011051"/>
    </dbReference>
    <dbReference type="OMA" id="NPYPGIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040353">
        <property type="entry name" value="FLX/FLX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405:SF7">
        <property type="entry name" value="PROTEIN FLX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33405">
        <property type="entry name" value="PROTEIN FLX-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43002" checksum="1C6212834E8B0E0D" modified="2016-04-13" version="1">MYEIRETQSTSSLLFRAQMSGRNRGPPLPMKGAPHAGVPPIYEPPFVRNLGPMPHHALLEEMREAQFGMGPRQLPPHPAIIEERFAAQHQDIQGLLVDNQRLAATHVALKQELEAAQHELQQTDRFARNFLMEKDMQMRELYEKSAKMEHDLHGVESMRAELMQFHADIKELTATRQKLTAQVQAMTQDLARANADLQQVPALKSEIEGLRQELQHARAAIEHEKKGHAENYEHGQVMEKNLLSMARELEKLRAEMANAEKRARAAAAVGNPNPGYNTNYGNAEANYAGNSYPASYGMSSMNQMNPVQPGAEGYPQYGPGPGSWGSYSILAVAKQDSPGLASTKGTLKGTSTGVKSLEEEWNILPKRVYDVILWSVWVPQFELEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKD2</accession>
    <name>A0A103YKD2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001005">
        <property type="protein sequence ID" value="KVI10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKD2"/>
    <dbReference type="STRING" id="59895.A0A103YKD2"/>
    <dbReference type="Gramene" id="KVI10658">
        <property type="protein sequence ID" value="KVI10658"/>
        <property type="gene ID" value="Ccrd_010946"/>
    </dbReference>
    <dbReference type="OMA" id="AHEAQTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389:SF41">
        <property type="entry name" value="GLYCINE-RICH PROTEIN 3 SHORT ISOFORM-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389">
        <property type="entry name" value="NODULIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119811" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="129" mass="13357" checksum="DEF96498FA0B443B" modified="2016-04-13" version="1">MASKTFLLLALAFAVVLLVSSQIAAAKDLDESEVEDAKYGRDDRGYYNGGGRGGYNGGGRGGYNNGGGRGGYNNGGGRGGYNHGGGRGRGYCRYGCCGGGRYYNGGCRCCSTLAEATAYKQAHEAQTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YM07</accession>
    <name>A0A103YM07_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit VII</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000064">
        <property type="protein sequence ID" value="KVI11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YM07"/>
    <dbReference type="STRING" id="59895.A0A103YM07"/>
    <dbReference type="Gramene" id="KVI11636">
        <property type="protein sequence ID" value="KVI11636"/>
        <property type="gene ID" value="Ccrd_009952"/>
    </dbReference>
    <dbReference type="OMA" id="QYESMDI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF7">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="19195" checksum="FE1ADBBA4330E1BA" modified="2016-04-13" version="1">MASSKLVKAILDPKKNWFAALHKKTIATRLSKYGLRYDDLYDPMECLDIKEALARLPREIVDARNQRLLRAMDLSMKHEYLTADLQAQQTPFRSYLTDMLALVCCRWWWWRWPPSGAGGSGGGGGCGCGGHEDGGEWWWLTMVDMVVRRERAEREALGALPLQQRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMI3</accession>
    <name>A0A103YMI3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000035">
        <property type="protein sequence ID" value="KVI11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMI3"/>
    <dbReference type="STRING" id="59895.A0A103YMI3"/>
    <dbReference type="Gramene" id="KVI11839">
        <property type="protein sequence ID" value="KVI11839"/>
        <property type="gene ID" value="Ccrd_009746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="73" mass="8365" checksum="835A6973BD07E8F4" modified="2016-04-13" version="1">MDFTMNKLRSLVSKWQSLIDAHVDIRRKMREVMVSQAQSCDLKVHGDYSEDVGVKMERPADKLIAEETEVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YN53</accession>
    <name>A0A103YN53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_009479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YN53"/>
    <dbReference type="Gramene" id="KVI12128">
        <property type="protein sequence ID" value="KVI12128"/>
        <property type="gene ID" value="Ccrd_009479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="117" mass="13623" checksum="4C2A3A4EAB30EFCD" modified="2016-04-13" version="1">MNERFKNLTMEFTDLGNVSLVTAYGLSFVGTFVTDRPINFHIMKHRLANLWRSWRGFLKCNSDVTLFRNENRAGIGWSSRMNMTTSLRIVRIVFMDYSLLGALQWAVESFSRSTILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRP9</accession>
    <name>A0A118JRP9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005676">
        <property type="protein sequence ID" value="KVH87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRP9"/>
    <dbReference type="STRING" id="59895.A0A118JRP9"/>
    <dbReference type="Gramene" id="KVH87952">
        <property type="protein sequence ID" value="KVH87952"/>
        <property type="gene ID" value="Ccrd_024701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF33">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="12810" checksum="A2CAC29D863B4933" modified="2016-04-13" version="1" fragment="single">IWGFCGFFVLPVKNWGLWHRDLCRYKFPLTLVLSYVNISFIDIFYDHSVCVNIPIVLCGKQVTFHRKKNLWYYEISAKSNYNFEKPFLYLGRKLDGHEGELAATASQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUJ5</accession>
    <name>A0A118JUJ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004813">
        <property type="protein sequence ID" value="KVH92574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUJ5"/>
    <dbReference type="STRING" id="59895.A0A118JUJ5"/>
    <dbReference type="Gramene" id="KVH92574">
        <property type="protein sequence ID" value="KVH92574"/>
        <property type="gene ID" value="Ccrd_005409"/>
    </dbReference>
    <dbReference type="OMA" id="NYPNMET"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF34">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="30858" checksum="F28128BA926D58A0" modified="2016-04-13" version="1">MSTLRTRLNLESTSVSLPPRHNPLKLLNLHGANKELRWRRRTQFRSFSVALRPIPPPTAVFFLMADTHSSGDADLNSVDRTFTEVVVVRHGETEWNAEKRIQGHLDIDLNDVGRQQAVAVAERLSGESNISAIYSSDLKRALETAQTIASRCGGLEVIQDPNLRERHLGDLQGLVYSEAPKIKTKAYEALQSHRKDVEIPGGGERERVVVVTHGGVIRALHQRASLGNGRRAGRILNVSVNVFHLSDPDKWDIKVWGDVGHLNGANYLDSGFGGDRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUY0</accession>
    <name>A0A118JUY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gibberellin regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004817">
        <property type="protein sequence ID" value="KVH92442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUY0"/>
    <dbReference type="STRING" id="59895.A0A118JUY0"/>
    <dbReference type="Gramene" id="KVH92442">
        <property type="protein sequence ID" value="KVH92442"/>
        <property type="gene ID" value="Ccrd_005491"/>
    </dbReference>
    <dbReference type="OMA" id="CCGKCNG"/>
    <dbReference type="OrthoDB" id="847210at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF100">
        <property type="entry name" value="GIBBERELLIN REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159708" evidence="2">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="92" mass="9875" checksum="3B619A5A2FFB6C2B" modified="2016-04-13" version="1">MKLSPFTVVIIIALLFTSAIAISPSAAPSGFGCDNKCEVRCSRSGWKDRCLKYCGICCGKCNGCVPSGPYASKAQCPCYRDMKNPKGRDKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWC8</accession>
    <name>A0A118JWC8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_003797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha, a beta and a gamma subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004568">
        <property type="protein sequence ID" value="KVH94137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWC8"/>
    <dbReference type="STRING" id="59895.A0A118JWC8"/>
    <dbReference type="Gramene" id="KVH94137">
        <property type="protein sequence ID" value="KVH94137"/>
        <property type="gene ID" value="Ccrd_003797"/>
    </dbReference>
    <dbReference type="OMA" id="QIMREGN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="8">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH94137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="288" mass="32657" checksum="42AB60AEAA8644B8" modified="2016-04-13" version="1">MAEEGNQIEVKDETPDFVFDGCNAVVPTHCHLHLAPFDPTKKKKKKKVVIQDPADDSVEQLVEKTESLSVSEGLEPTFTGLKKKKKKQVQTDLLEDDKENAEEDVDYPTGEDEEGEGIVLEQQKLPWEGTDRDYKYEELLGRVFHILRENNPELAGDRRRTVMRPPQVLREGTKKTVFVNFMDLCKSMHRQPEHAMTFLLAELGTSGSLDGQQRLVVKGRFAPKNFEGILRRYVNEYVICNGCKSPDTILSKENRLFFLRCEKCGSGRSVAQIKAGFVARVGRRKAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX23</accession>
    <name>A0A118JX23_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_001748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004352">
        <property type="protein sequence ID" value="KVH96161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX23"/>
    <dbReference type="Gramene" id="KVH96161">
        <property type="protein sequence ID" value="KVH96161"/>
        <property type="gene ID" value="Ccrd_001748"/>
    </dbReference>
    <dbReference type="OMA" id="EMEMMNE"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012891">
        <property type="entry name" value="GCK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34357:SF2">
        <property type="entry name" value="F26F24.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34357">
        <property type="entry name" value="F7A19.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07802">
        <property type="entry name" value="GCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01227">
        <property type="entry name" value="GCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCK" evidence="2">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14135" checksum="1F29C0BA19114FC4" modified="2016-04-13" version="1">MSTPHPDKPQNQDQDRTDPSPPHEETEDEGECGFCLFMKGGECRENFIDWEKCIEEGEKNNEDVVEKCFEVTSSLKKCMEAHPDYYGPILQAEKAAQQEAINQLDKEKEAMAAASDTEKQQQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYB9</accession>
    <name>A0A118JYB9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_000170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003821">
        <property type="protein sequence ID" value="KVH97707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYB9"/>
    <dbReference type="Gramene" id="KVH97707">
        <property type="protein sequence ID" value="KVH97707"/>
        <property type="gene ID" value="Ccrd_000170"/>
    </dbReference>
    <dbReference type="OMA" id="GNSIQMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000006">
        <property type="entry name" value="WRKY transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF130">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH97707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="410" mass="44547" checksum="56262D256A771B87" modified="2016-04-13" version="1">MDEKRRLISSSAPYLRPTISIPSSSTVENLFTGGGGRPGESPGPMTLISNFFSNNDVESDCRSFSQLLAGTMSSPAQIPGRILSRDSDAGADASGGGAAVDFQFSNAGRASGLVVTQASTFTIPPGLSPATLLDSPGFFLPAQSPEFSSSGGHSHSHSQPPSVAADKPSEDGYNWRKYGQKQVKGSEYPRSYYKCTNQNCRVKKKVERNLDGLVTEIIYNGQHNHQPPRSEYAGVGTSGEPESFKGQTGNFNHSRVDAMSMKGDQRSGSSDGKEASDDVTMPQAKRRNVEVKAVDPVSSHRTVTEPRIVVQATSEIDLLDDGYKWRKYGQKVVKGNRHPRHCTSQGCKVRKHVERAASDPMAVITTYEGKHNHLVPVVRNNNHDTTKETASQLRPHGPIGHLRLKDEQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYS9</accession>
    <name>A0A118JYS9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRF2/HOY1 PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYS9"/>
    <dbReference type="STRING" id="59895.A0A118JYS9"/>
    <dbReference type="Gramene" id="KVH99041">
        <property type="protein sequence ID" value="KVH99041"/>
        <property type="gene ID" value="Ccrd_022725"/>
    </dbReference>
    <dbReference type="OMA" id="SHIGQCI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33494:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33494">
        <property type="entry name" value="OS02G0793800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRF2/HOY1 PH-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="428" mass="47906" checksum="AF53913B31A47A32" modified="2016-04-13" version="1">MVQMMKTTKVSPESQFQQRGKMAPVKREMAEEFIQYDEQYSHLNKRSKFNPLDEPSPLGLRLRKSPSLLDLIQMRLAEGNASSKIGADGKKGTKIIASSAASDKLKASNFPASLLKIGDLVAKCYFAKHKLVWEVLDGGLKNKIEIQWSDIMALKATRHYLQCPQGLLGKHFEKLIQCDPRLNFLSQQAEIELESPYFEPRTSSVFDEPNESNEYDLSREGPAIFDLRRTASPSGGQSSSSRSELHDPAVMDTSAIEEIRRAGTEGPKGLDLWDQIKVPGIQPSMSMSDLVNHIENRITGQRTSGNHHPLSREEQESLEILEDISRCLFNDAQYGTSTSDENSVMSKVNSLCCLLQKDPTTFQDLEGKTVSDNNRISYETKPVSENPVIEGENDDGKKVSGMSRKDSVGELLLNLPRIASLPRFFYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ09</accession>
    <name>A0A118JZ09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Calreticulin/calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_022740</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003638">
        <property type="protein sequence ID" value="KVH99056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ09"/>
    <dbReference type="STRING" id="59895.A0A118JZ09"/>
    <dbReference type="Gramene" id="KVH99056">
        <property type="protein sequence ID" value="KVH99056"/>
        <property type="gene ID" value="Ccrd_022740"/>
    </dbReference>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000048">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006990278" evidence="17">
        <location>
            <begin position="29"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="505"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH99056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="548" mass="61677" checksum="E4DAF6AE709636F0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ72</accession>
    <name>A0A118JZ72_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003630">
        <property type="protein sequence ID" value="KVH99237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ72"/>
    <dbReference type="STRING" id="59895.A0A118JZ72"/>
    <dbReference type="Gramene" id="KVH99237">
        <property type="protein sequence ID" value="KVH99237"/>
        <property type="gene ID" value="Ccrd_022540"/>
    </dbReference>
    <dbReference type="OMA" id="IVGLHPC"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="57369" checksum="1D5841EA0A5DE66A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZA7</accession>
    <name>A0A118JZA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Harbinger transposase-derived nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_023384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003800">
        <property type="protein sequence ID" value="KVH98380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZA7"/>
    <dbReference type="STRING" id="59895.A0A118JZA7"/>
    <dbReference type="Gramene" id="KVH98380">
        <property type="protein sequence ID" value="KVH98380"/>
        <property type="gene ID" value="Ccrd_023384"/>
    </dbReference>
    <dbReference type="OMA" id="CETHSEG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF288">
        <property type="entry name" value="HARBINGER TRANSPOSASE-DERIVED NUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="138"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH98380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="38919" checksum="33790944067C215E" modified="2016-04-13" version="1">MNDKKPMQQRRRKVAKKTEVADMEGKQEIKTTSLFFLDQEKPGKHDDVNCLGKRKSRTPSIVPDVAVADLGYDLNLGGGGAAVKGGGDGPQRRLWVCSAIKDVLMPKYLQWPNDDSIRVISNEFDSVSGIPNVVGSMYTTHIPIIAPKVNVSAYFNKCHTEKKHKTCYSVTIQGVVDPSGVFTDVCIGWPGSMPDDQVLENSALYQRAMGGLLKGVWIVGGCGYPLMDWVLVPYKQPHLTWTQHAFNEKIGEIQKVSKDAFARLKGRWSCLQKRTEMKLQDLPVVLGACCVLHNICEIRSEKIESQLMIEVVDDEMVPENGLRSPMAMKARDSMAHNLLHHNHAGTSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZD6</accession>
    <name>A0A118JZD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003627">
        <property type="protein sequence ID" value="KVH99267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZD6"/>
    <dbReference type="STRING" id="59895.A0A118JZD6"/>
    <dbReference type="Gramene" id="KVH99267">
        <property type="protein sequence ID" value="KVH99267"/>
        <property type="gene ID" value="Ccrd_022501"/>
    </dbReference>
    <dbReference type="OMA" id="EMFKRQV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="140" mass="15769" checksum="91FEEFF82330F48A" modified="2016-04-13" version="1">MLIFLRGIFSNTLHAISIKYMKDMELGVLSDMPDIQKKACWKLLKQQVLHHDKLVSSYKDMVATVVNMVNISTSLRCFLKGGTSSPLIQFSNSSEDINDNGDGGGIPVFTFWSISSFEKSASELVQMFKLELYLKCSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0I3</accession>
    <name>A0A118K0I3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_021173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003371">
        <property type="protein sequence ID" value="KVI00586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI00586">
        <property type="protein sequence ID" value="KVI00586"/>
        <property type="gene ID" value="Ccrd_021173"/>
    </dbReference>
    <dbReference type="OMA" id="YLHIERC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF61">
        <property type="entry name" value="NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="1517"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2151" mass="242751" checksum="39AAD94E8FFAF0B4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0T1</accession>
    <name>A0A118K0T1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002678">
        <property type="protein sequence ID" value="KVI01848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0T1"/>
    <dbReference type="STRING" id="59895.A0A118K0T1"/>
    <dbReference type="Gramene" id="KVI01848">
        <property type="protein sequence ID" value="KVI01848"/>
        <property type="gene ID" value="Ccrd_019872"/>
    </dbReference>
    <dbReference type="OMA" id="PNESLCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF62">
        <property type="entry name" value="4-COUMARATE--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10751" checksum="23049FDBA13F34DE" modified="2016-04-13" version="1">MKETIESVPSDGKTVGEIVLQRSNIMKGYLKGEKETAKAFHKGWFFAGDVGVIHPNGHLEIKDRSKDVNILGGENIRSVELESICNTLLSILAILPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Y6</accession>
    <name>A0A118K0Y6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020088</name>
        <name evidence="12" type="ORF">Ccrd_026759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01009355">
        <property type="protein sequence ID" value="KVF49263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01002925">
        <property type="protein sequence ID" value="KVI01635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Y6"/>
    <dbReference type="STRING" id="59895.A0A118K0Y6"/>
    <dbReference type="Gramene" id="KVF49263">
        <property type="protein sequence ID" value="KVF49263"/>
        <property type="gene ID" value="Ccrd_026759"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI01635">
        <property type="protein sequence ID" value="KVI01635"/>
        <property type="gene ID" value="Ccrd_020088"/>
    </dbReference>
    <dbReference type="OMA" id="WIVSICM"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="111"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVF49263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI01635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="242" mass="27081" checksum="A57BD688911EA4E7" modified="2016-04-13" version="1">MSMYGRDPWGGPLEINTADSATDDDRSRNLNDFDRAALSRPLDETQQSWLLGPGEQKKKRYVDLGCIIVSRKIFIWTVGTILAVAFTAGIITVIVKNVPRHHKHPPAPDNYTIALQKALKFFNAQKSGKLPKHNNVSWRGNSCLNDGKLDKSGAVIKDLVGGYYDAGDAIKFHFPKAFAMTMLSWSVIEYSAKYEAAGELAHVKEIIKWGTDYFLKTFNSTADTISQLVAQVDFEIFFQCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K127</accession>
    <name>A0A118K127_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002673">
        <property type="protein sequence ID" value="KVI01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K127"/>
    <dbReference type="STRING" id="59895.A0A118K127"/>
    <dbReference type="Gramene" id="KVI01905">
        <property type="protein sequence ID" value="KVI01905"/>
        <property type="gene ID" value="Ccrd_019819"/>
    </dbReference>
    <dbReference type="OMA" id="GWNESHR"/>
    <dbReference type="OrthoDB" id="5900at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022051">
        <property type="entry name" value="DUF3611"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34548">
        <property type="entry name" value="PROTEIN TIC 21, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34548:SF2">
        <property type="entry name" value="PROTEIN TIC 21, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12263">
        <property type="entry name" value="DUF3611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="284" mass="30209" checksum="B9970FE5771401A8" modified="2016-04-13" version="1">MQILMLPGARTGIAPPSLAAAQPSPLLLHRPLSALNFVSSVTSSTQRCLSLTSSSSQFSLHSYRRRIRKPNKLTSAPISAAYVPPNYESDKSKFAQVSKKLENTSRYFKRLGSLGFWGQLACTTVAAAILSFSVVITGKISSPVTFYATAGGIAAAFLSVFWSFGYIRLSDRLRKTANDPSKAPPRADVVKGLKNGIVLNLLGMGAAILGMQATVGTLVAKALTTSANPLYRSGSSPILALDVFLVQASANTILSHFLGLVFSLELLRSVTIPPSESIHVPKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2V5</accession>
    <name>A0A118K2V5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_016722</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001896">
        <property type="protein sequence ID" value="KVI04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2V5"/>
    <dbReference type="Gramene" id="KVI04950">
        <property type="protein sequence ID" value="KVI04950"/>
        <property type="gene ID" value="Ccrd_016722"/>
    </dbReference>
    <dbReference type="OMA" id="FRFHRKK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000004">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF932">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="16">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="17">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="390"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVI04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="684" mass="76569" checksum="9262109E0147D57F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2Y5</accession>
    <name>A0A118K2Y5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Concanavalin A-like lectin/glucanase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_016576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2Y5"/>
    <dbReference type="Gramene" id="KVI05100">
        <property type="protein sequence ID" value="KVI05100"/>
        <property type="gene ID" value="Ccrd_016576"/>
    </dbReference>
    <dbReference type="OMA" id="HNVLSWN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159911" evidence="13">
        <location>
            <begin position="28"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="389"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="682" mass="76043" checksum="D2C734B2C0BDFDB3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S0J2</accession>
    <name>A0A124S0J2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006703">
        <property type="protein sequence ID" value="KVH56141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124S0J2"/>
    <dbReference type="Gramene" id="KVH56141">
        <property type="protein sequence ID" value="KVH56141"/>
        <property type="gene ID" value="Ccrd_025677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH56141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="7729" checksum="A2A24E7C25BD0190" modified="2016-04-13" version="1" fragment="single">MMKMMTLTIVTPLKRLTPNWKAPFLTLEILEQQINGSSVTHPRMGSSHHHLFITSITMDRSLTPPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAW7</accession>
    <name>A0A124SAW7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat stress transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_025756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005339">
        <property type="protein sequence ID" value="KVH88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SAW7"/>
    <dbReference type="Gramene" id="KVH88765">
        <property type="protein sequence ID" value="KVH88765"/>
        <property type="gene ID" value="Ccrd_025756"/>
    </dbReference>
    <dbReference type="OMA" id="NMLMQEL"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000057">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF325">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR A-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="12">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="40505" checksum="8271E78DFA4091EC" modified="2016-04-13" version="1">MVKKSTEIGGLSIAPFLLKCYEMVDDPTTDALISWSPTNDSFIVWNEXEFTSELLPKYFKHNNYSSFQRQLNIYGFRKTDTDRWEFANDGFVKGQKHLLNSINRKKVTQVTAQQKVTQQKAPELAKLIDVSKHEEKLWKEVESLKTDKNMLMQELIKQREHQETSQTKMLVLREQLKGMEKNQHQMLSFIVMAMQSPGFFSQLSPPVQRTWLKSERSSKTILKPVTKDSKRVVHPQEGAIVKYQPPIETPAIILEDPVELDLTCEDLFMDFMPGSTLDDGINSPENLVPFIFHDLPDSENMLDQLLSSPVNKTSKDLIDDGRGTQEIGPDGFQFLTEGFGRSLTVSTKEGNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAX3</accession>
    <name>A0A124SAX3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_024902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005327">
        <property type="protein sequence ID" value="KVH88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAX3"/>
    <dbReference type="STRING" id="59895.A0A124SAX3"/>
    <dbReference type="Gramene" id="KVH88870">
        <property type="protein sequence ID" value="KVH88870"/>
        <property type="gene ID" value="Ccrd_024902"/>
    </dbReference>
    <dbReference type="OMA" id="FRGIHHF"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000071">
        <property type="entry name" value="probable ADP,ATP carrier protein At5g56450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF31">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="239"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36489" checksum="C73C17C43C0FB9BD" modified="2016-04-13" version="1">MVAEDGDEASSRGSKPNKSEMVMMHSYWLTNFPRDLMAGAMMGGMVHTVVAPIERAKLLLQTQESNIAIVGGKHRRFNGMIDCIVHTVKEEGVLSLWRGNGSSVLRYYPSVALNFSLKDLYKSVLRSRSSQQSTFLSGPPANFIAGAAAGCTTLVIIYPLDIAHTRLAADLGRMESRQFHGIRHFLVTVWAKDGIRGIYKGLPASLQGMVVHRGLYFGGFDTLKERMSKDAPSEVALWKRWIVAQAVTSSAGLLSYPMDTVRRRMMMQSGIEQPMYRSTLDCWKTIYSTEGFRSFYRGALSNIFRSTGAAAILVLYDEVKKFMDWGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBA1</accession>
    <name>A0A124SBA1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_008005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005119">
        <property type="protein sequence ID" value="KVH89995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBA1"/>
    <dbReference type="STRING" id="59895.A0A124SBA1"/>
    <dbReference type="Gramene" id="KVH89995">
        <property type="protein sequence ID" value="KVH89995"/>
        <property type="gene ID" value="Ccrd_008005"/>
    </dbReference>
    <dbReference type="OMA" id="NTIDETC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF99">
        <property type="entry name" value="ABSCISIC ACID RECEPTOR PYL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH89995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="17473" checksum="829C9A7A091BE13B" modified="2016-04-13" version="1" fragment="single">MAITGDGANLPEIDYIKRHHKHEVRAYQCTSSLLKRIKAPVHLVWSLVRRFDQPQKYKPFVSGCNVQGGDLEIGSVREVNVRSGLPATTSTERLELLNEEEHILGMRIVGGDHRLQGNTTDETCYFVEALVKCNLKSLADVSERLAVQDSTESIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBC3</accession>
    <name>A0A124SBC3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBC3"/>
    <dbReference type="STRING" id="59895.A0A124SBC3"/>
    <dbReference type="Gramene" id="KVH90205">
        <property type="protein sequence ID" value="KVH90205"/>
        <property type="gene ID" value="Ccrd_007768"/>
    </dbReference>
    <dbReference type="OMA" id="ANDWKNA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF1">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 16-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="16575" checksum="5BCF4B0A72DFEAC3" modified="2016-04-13" version="1">MGHNLETRSLLDELRSFDKNGGIFDLGHPLLNRMAESFVKAAGIGAVQAVSREAYFTAFEENLLKHWSKARGKNLYNGVKTCVLVHGLAAGMYSGITYGLKEARGVHDWKNSAVAGAITGAALALTFDDSSHEQIVHGAITGAALSTAANLLTGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD33</accession>
    <name>A0A124SD33_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum, stress-associated Ramp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_002228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004379">
        <property type="protein sequence ID" value="KVH95696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD33"/>
    <dbReference type="STRING" id="59895.A0A124SD33"/>
    <dbReference type="Gramene" id="KVH95696">
        <property type="protein sequence ID" value="KVH95696"/>
        <property type="gene ID" value="Ccrd_002228"/>
    </dbReference>
    <dbReference type="OMA" id="ATKFITQ"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF35">
        <property type="entry name" value="OS07G0583000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="7410" checksum="D3DFA85696F9D57C" modified="2016-04-13" version="1">MTTSRRLADKKVGRFDKNITRRGSVPETSTKKGNNYPVGPIMLGFFVFVVIGSSLFQIIRTATSGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDT9</accession>
    <name>A0A124SDT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Avr9/Cf-9 rapidly elicited protein 146</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003814">
        <property type="protein sequence ID" value="KVH97992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDT9"/>
    <dbReference type="Gramene" id="KVH97992">
        <property type="protein sequence ID" value="KVH97992"/>
        <property type="gene ID" value="Ccrd_023804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33265">
        <property type="entry name" value="AVR9/CF-9 RAPIDLY ELICITED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33265:SF31">
        <property type="entry name" value="AVR9_CF-9 RAPIDLY ELICITED PROTEIN 146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119173" checksum="5845C7113A332AB2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SEV0</accession>
    <name>A0A124SEV0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003123">
        <property type="protein sequence ID" value="KVI01232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SEV0"/>
    <dbReference type="Gramene" id="KVI01232">
        <property type="protein sequence ID" value="KVI01232"/>
        <property type="gene ID" value="Ccrd_020499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176193" evidence="2">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="254" mass="27772" checksum="C745696FF76EA9DD" modified="2016-04-13" version="1">MNMNMMMKMMLVLVYLINHLDASPVYLHGRSLRLFNFNPFKLKPFRVNPELPFRFPKPKPSVDFPTVPLPLLRPFPRPRPSGKPTVEHPTTNPDHPYAKPTPLNPPDRTTRLRALTCKFACKAVIDSAVAEAGASNSNSRCLAEIAKASVQQLCTDACSKQRSGIRPTLITAGNAAFAACANSRVAGPDPPGNEYAETSNDAAASSFGAESLPPPLLLHSIVPEEKEHKEVYKHGFVPLGTGRVRSGRLRMGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFN1</accession>
    <name>A0A124SFN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002330">
        <property type="protein sequence ID" value="KVI03798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFN1"/>
    <dbReference type="STRING" id="59895.A0A124SFN1"/>
    <dbReference type="Gramene" id="KVI03798">
        <property type="protein sequence ID" value="KVI03798"/>
        <property type="gene ID" value="Ccrd_017898"/>
    </dbReference>
    <dbReference type="OMA" id="SCENGQT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="203" mass="23321" checksum="117A11299EA64CA4" modified="2016-04-13" version="1">MVSIRRQRLIKLYGRGPSLDFLSCENGQTSGNWAQNTRQVSMHPTPSVDIDQSIEEKAKYEEPESSNVNESSSSNKQPIQHPVFKRRKRHRRKHFENQEPCIMRGVYYKNMKWQAAIKVDKKQIHLGTVGSQEEAARLAAFMCGREPNFELTVEEKDELKHQRRVTSRMKFEHPSQNNGERKAKVDRGGNSFSASDDAETSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFP1</accession>
    <name>A0A124SFP1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_017822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFP1"/>
    <dbReference type="STRING" id="59895.A0A124SFP1"/>
    <dbReference type="Gramene" id="KVI03853">
        <property type="protein sequence ID" value="KVI03853"/>
        <property type="gene ID" value="Ccrd_017822"/>
    </dbReference>
    <dbReference type="OMA" id="CTYEEMR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF30">
        <property type="entry name" value="ROOT UVB SENSITIVE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="179" mass="20440" checksum="19DEFDFB7474CCE9" modified="2016-04-13" version="1">MVVGPFLSAVHVYCTYEEMRAAPVNTLNPQRTAMIIEDFLETGKISSPADLRYREDLLFPKRVIEGAGNVKVGRDLHKVIKPSRLEQFKEIFPDEKFVLEFGNRWTDMVLEQNASGEDALRGWLVAALASPVVENREVEMVEVAYEKMNTMMPRLLSELRAKGWHTDRFLDGTGSRYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFQ3</accession>
    <name>A0A124SFQ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_017701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002319">
        <property type="protein sequence ID" value="KVI03978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SFQ3"/>
    <dbReference type="Gramene" id="KVI03978">
        <property type="protein sequence ID" value="KVI03978"/>
        <property type="gene ID" value="Ccrd_017701"/>
    </dbReference>
    <dbReference type="OMA" id="MKRCIWN"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="428"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI03978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="550" mass="63282" checksum="E147938B960E3EB7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGQ4</accession>
    <name>A0A124SGQ4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_014501</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001518">
        <property type="protein sequence ID" value="KVI07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGQ4"/>
    <dbReference type="STRING" id="59895.A0A124SGQ4"/>
    <dbReference type="Gramene" id="KVI07138">
        <property type="protein sequence ID" value="KVI07138"/>
        <property type="gene ID" value="Ccrd_014501"/>
    </dbReference>
    <dbReference type="OMA" id="GPLFWQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06632">
        <property type="entry name" value="STKc_MEKK1_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000186">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF45">
        <property type="entry name" value="OS04G0559800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="411"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="892" mass="96494" checksum="15662ED123708077" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHE3</accession>
    <name>A0A124SHE3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001066">
        <property type="protein sequence ID" value="KVI09298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHE3"/>
    <dbReference type="Gramene" id="KVI09298">
        <property type="protein sequence ID" value="KVI09298"/>
        <property type="gene ID" value="Ccrd_012325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10598" checksum="90D9B78FD6279957" modified="2016-04-13" version="1">MKLRKVESLGDKDDLRARQIEQVRIKILEHFHSYLFPIMSSHFDPKLSTSRVPAATLNVKGVKLALIVCEQSIVTSRPIQSVGGGLIPSERSNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHR6</accession>
    <name>A0A124SHR6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase-like, plant mobile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001021">
        <property type="protein sequence ID" value="KVI10366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHR6"/>
    <dbReference type="STRING" id="59895.A0A124SHR6"/>
    <dbReference type="Gramene" id="KVI10366">
        <property type="protein sequence ID" value="KVI10366"/>
        <property type="gene ID" value="Ccrd_011233"/>
    </dbReference>
    <dbReference type="OMA" id="NENPWIS"/>
    <dbReference type="OrthoDB" id="1572276at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010073">
        <property type="term" value="P:meristem maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019557">
        <property type="entry name" value="AminoTfrase-like_pln_mobile"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044824">
        <property type="entry name" value="MAIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033:SF67">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE, PLANT MOBILE DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033">
        <property type="entry name" value="PROTEIN MAIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10536">
        <property type="entry name" value="PMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase-like plant mobile" evidence="3">
        <location>
            <begin position="88"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI10366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="563" mass="64492" checksum="79323A3B6FE76BCA" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBP7</accession>
    <name>A0A103XBP7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S10, serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005847">
        <property type="protein sequence ID" value="KVH87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBP7"/>
    <dbReference type="Gramene" id="KVH87781">
        <property type="protein sequence ID" value="KVH87781"/>
        <property type="gene ID" value="Ccrd_024933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF382">
        <property type="entry name" value="PEPTIDASE S10, SERINE CARBOXYPEPTIDASE, ALPHA_BETA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="171" mass="19180" checksum="500D81BF03340F60" modified="2016-04-13" version="1" fragment="single">VANVIYLDAPTLTGYSYTKTSKAIRSSDTLSASQTIEFIRKVSGSSTYTYRVSSFVDIYVQLLQFVRDHPKFLNNPMYVTGISYSGIVIPIITEEFNNEVLEPTINIKGYIAGNPLTDKTGDIDSRLEYVYRMALISKELFESTRNGCNGEYAEADSNNLLCMSNIHEVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBY3</accession>
    <name>A0A103XBY3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_024782</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005726">
        <property type="protein sequence ID" value="KVH87904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XBY3"/>
    <dbReference type="Gramene" id="KVH87904">
        <property type="protein sequence ID" value="KVH87904"/>
        <property type="gene ID" value="Ccrd_024782"/>
    </dbReference>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003492">
        <property type="entry name" value="AGAP012735-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="936"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1377"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="332"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="593"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="901"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1221"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH87904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1650" mass="184798" checksum="60FE158CE6D9C73D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDB3</accession>
    <name>A0A103XDB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Berberine/berberine-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_026208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005355">
        <property type="protein sequence ID" value="KVH88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XDB3"/>
    <dbReference type="Gramene" id="KVH88650">
        <property type="protein sequence ID" value="KVH88650"/>
        <property type="gene ID" value="Ccrd_026208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000004">
        <property type="entry name" value="Berberine bridge enzyme-like 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118694" evidence="12">
        <location>
            <begin position="18"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="69"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="821"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119426" checksum="6E66943F59A72FAF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE12</accession>
    <name>A0A103XE12_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005325">
        <property type="protein sequence ID" value="KVH88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE12"/>
    <dbReference type="Gramene" id="KVH88934">
        <property type="protein sequence ID" value="KVH88934"/>
        <property type="gene ID" value="Ccrd_024669"/>
    </dbReference>
    <dbReference type="OMA" id="KPHHQLD"/>
    <dbReference type="OrthoDB" id="1302889at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040389">
        <property type="entry name" value="SMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142:SF40">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12605" checksum="A54FBEDBF3FDFD60" modified="2016-04-13" version="1">MGIAEETMESETTAKKWVIAGIQFMSPLKPIYTKKEIGKTHEEEGNKEEEEEEKECCTTPTTPESRIPCLLKCPGAPMKRKAVSRSHCNGVRDYFKPPDLESVFIRCIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF75</accession>
    <name>A0A103XF75_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005194">
        <property type="protein sequence ID" value="KVH89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF75"/>
    <dbReference type="STRING" id="59895.A0A103XF75"/>
    <dbReference type="Gramene" id="KVH89630">
        <property type="protein sequence ID" value="KVH89630"/>
        <property type="gene ID" value="Ccrd_008378"/>
    </dbReference>
    <dbReference type="OMA" id="SNPGAMN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="156" mass="16903" checksum="0A311A2B7DDBC846" modified="2016-04-13" version="1">MQNRRSQFQQQPDFHITSSTILASTLHITRLNPLRNLTAPPINTTNPTSGPGLRGGQQPIQTNEMPENPETTQTQPGNENMNRVGNHLQAAVQPDGGGSNPGAMNSFSSLLLWILGGASSEGLSSFLSMFRDVRDQGGQAYAESPRQENRSTQTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFA6</accession>
    <name>A0A103XFA6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4408 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005196">
        <property type="protein sequence ID" value="KVH89609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFA6"/>
    <dbReference type="STRING" id="59895.A0A103XFA6"/>
    <dbReference type="Gramene" id="KVH89609">
        <property type="protein sequence ID" value="KVH89609"/>
        <property type="gene ID" value="Ccrd_008427"/>
    </dbReference>
    <dbReference type="OMA" id="HYHIENQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025520">
        <property type="entry name" value="DUF4408"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098:SF75">
        <property type="entry name" value="DUF4408 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14364">
        <property type="entry name" value="DUF4408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4408" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="43682" checksum="483637C2F215E09E" modified="2016-04-13" version="1">MGSSSSSLSQRILLISAGVVLVAMAMTFCFPAMLNLAVYHIPAIWSVILSWLRPPYLYIIINGIIITIAASSRFHHLHNHYHIENQSQPLVDETNTVLPLDLPSESPPMVILPSFDVVENPPVVYESEHTETEENPTVYESEPPLTDVKTVAVNGTDFVADFVTDESEDKFIISRSEWNPPHRMIKPPPPERKIKSEFISPAREKMLVSSRFSHQRKSAKFNPEGTTSYSTGVRSLRVAKSRKHETLENTWKTITDGRHIPLNRHLRKSDVFENNHHHHHHTPSLDGYSGEHGPAFAAADNNVMNKAETFNDRTAYDNENHQRILSSKNSMTSSGGKLRKEGSLSHDELNRRVEAFIKKFNDEMRLQRQESLQRYMDMINRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFC9</accession>
    <name>A0A103XFC9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allyl alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005150">
        <property type="protein sequence ID" value="KVH89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFC9"/>
    <dbReference type="STRING" id="59895.A0A103XFC9"/>
    <dbReference type="Gramene" id="KVH89730">
        <property type="protein sequence ID" value="KVH89730"/>
        <property type="gene ID" value="Ccrd_008273"/>
    </dbReference>
    <dbReference type="OMA" id="FEPCRWE"/>
    <dbReference type="OrthoDB" id="1925587at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10952" checksum="017958229CF80159" modified="2016-04-13" version="1">MGILSWWKGNKDSASSGVKTTDSKAIVSVEKAAEEVPAMNGAVEVLRPALDVDVTVFEFGSVAVSADKVTLAGYCPVSDDFEPCRWEILPASGSDAPQFRVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG28</accession>
    <name>A0A103XG28_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Superoxide dismutase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_007947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005118">
        <property type="protein sequence ID" value="KVH90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG28"/>
    <dbReference type="STRING" id="59895.A0A103XG28"/>
    <dbReference type="Gramene" id="KVH90120">
        <property type="protein sequence ID" value="KVH90120"/>
        <property type="gene ID" value="Ccrd_007947"/>
    </dbReference>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000006">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000042">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="32354" checksum="B0406BFDB4CBB8FB" modified="2016-04-13" version="1">MGFLRTISTTTAVTTTAAALALNSLAPSSTSSSSYNYNFTKPFLNSSSPASSRFGLMKTLAAPPPALHMDAKPALKHDAELPEVMTEFMVDMSCEGCVKAVKNKLQTVDGIKTIDVDLSNQVVRIFGSSPVKIMAEALEQTGRKARLIGQGSPGDVFISAAVAEFKGPEIFGVVRLAQVSMELARIEANFSGLSPGKHAWSINEFGDLTRGAASTGKLFNPIKQQLSDEKKGEAFFSGVKHNLTIGDLVGRAIAVYESEDRSDTGLAAAVIARSAGVGENYKKLCTCDGTTIWEATNADYVTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XG65</accession>
    <name>A0A103XG65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005116">
        <property type="protein sequence ID" value="KVH90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XG65"/>
    <dbReference type="Gramene" id="KVH90141">
        <property type="protein sequence ID" value="KVH90141"/>
        <property type="gene ID" value="Ccrd_007859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="130" mass="14379" checksum="C0A9008CB3148F82" modified="2016-04-13" version="1" fragment="single">MLVSAIESENNNHSLPLESVNTTGSSEENSSSSPPENCSTLSDEPEKLFESLCEDEKLLSYLLGDDEPPLVDTTSWDLPNNAHNFNNCTGSFTSWDDCATWLLDCQDFGVNDFGLDCFNQVEMSILDTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH37</accession>
    <name>A0A103XH37_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_007467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH37"/>
    <dbReference type="STRING" id="59895.A0A103XH37"/>
    <dbReference type="Gramene" id="KVH90589">
        <property type="protein sequence ID" value="KVH90589"/>
        <property type="gene ID" value="Ccrd_007467"/>
    </dbReference>
    <dbReference type="OMA" id="RWYWLAS"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF55">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="10">
        <location>
            <begin position="349"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="539" mass="59027" checksum="D2ECC5666110F167" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ29</accession>
    <name>A0A103XJ29_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_006398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ29"/>
    <dbReference type="STRING" id="59895.A0A103XJ29"/>
    <dbReference type="Gramene" id="KVH91568">
        <property type="protein sequence ID" value="KVH91568"/>
        <property type="gene ID" value="Ccrd_006398"/>
    </dbReference>
    <dbReference type="OMA" id="MATPIQA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37987" checksum="E5DE57C23A37EFBC" modified="2016-04-13" version="1">MGSTVCISPATFTGIRLSSSRSRSSKSSISFLSFLTNPNRNFVSKHISSLSSSSMASSTLQVHASSSTGAASEELDSSYAATVGANDLLIVGPGVLGRLVAEKWREEHPGCQITGETITTDHHEELIKMGIHPTLKGVKRDHKFPYVIFCAPPSRSSDYASDVGGAASLWNGEGSFLFTSSSAPYDRYDNGECYEDSPVVPIGKSPRTDVLLKAEKIVLDAGGCVHKADRGMHLYYLKVGTIEANAHHIVNLIHYEDAASLSVAILKKKLRNRLFLGCDNHPVSRQEVMDLVAKSGKFDQTFVGFTGTDGLLGKKLNNSRTREEIGWEPKYTSFAHFLGVAGIFSWNNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJJ4</accession>
    <name>A0A103XJJ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJJ4"/>
    <dbReference type="STRING" id="59895.A0A103XJJ4"/>
    <dbReference type="Gramene" id="KVH91838">
        <property type="protein sequence ID" value="KVH91838"/>
        <property type="gene ID" value="Ccrd_006147"/>
    </dbReference>
    <dbReference type="OMA" id="KDILHWE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="226" mass="25342" checksum="B716CE5F95AACB2D" modified="2016-04-13" version="1">MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPPDSPYSGGVFLVTIHFPPDYPFKPPKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRSKYETTARSWTQKYAMVMASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPPDSPYAGGVFLVTIHFPPDYPFKPPKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRNKYETTARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL06</accession>
    <name>A0A103XL06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004810">
        <property type="protein sequence ID" value="KVH92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL06"/>
    <dbReference type="STRING" id="59895.A0A103XL06"/>
    <dbReference type="Gramene" id="KVH92668">
        <property type="protein sequence ID" value="KVH92668"/>
        <property type="gene ID" value="Ccrd_005287"/>
    </dbReference>
    <dbReference type="OMA" id="TCCHLDS"/>
    <dbReference type="OrthoDB" id="272750at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF1">
        <property type="entry name" value="OS10G0330400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="33390" checksum="865D58FBE1D5F224" modified="2016-04-13" version="1">MEACFLSSNSFTKSMEIVIPSIKSRIFVQQPKKKRSSSQFQIRKATIHSPATCCQSQSNSPSPSSRDEENPSIDADWRLFRARLVAGEQALPSQESSPTTDPDTVPNQPPSISIGDKWAHAIHEPEKGCLLIATEKLDGVHIFERTVVLLLSTGPVGPTGIILNRPSLMSIKEMRSTTTLDVSGTFSDRPLFFGGPLEEGLFLVGGGDGVRKSGVFEEVMKGLFYGTKESVGCASEMVKRNVVGLGEFRFFDGYCGWEKEQLRDEIKGGYWAVAACSPNVIGLDNVGRVGLWEEVIGLMGQKKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN48</accession>
    <name>A0A103XN48_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOUL heme-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004603">
        <property type="protein sequence ID" value="KVH93773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN48"/>
    <dbReference type="STRING" id="59895.A0A103XN48"/>
    <dbReference type="Gramene" id="KVH93773">
        <property type="protein sequence ID" value="KVH93773"/>
        <property type="gene ID" value="Ccrd_004175"/>
    </dbReference>
    <dbReference type="OMA" id="CSEKIQW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF50">
        <property type="entry name" value="SOUL HEME-BINDING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36061" checksum="DAC3ABAA6ECDD3FB" modified="2016-04-13" version="1">MATAHLSGTVIRPISCNYVTHRKLKSPGSSVFFIKQFRNRALVDNRTRIRLSLVEQIPPKSSKVDVERLVDFLYEDLPHLFDDQGIDRTAYDEQVKFRDPITKHDSISGYLFNIAMLKLVFSPNFQLHWVRQTGPYELTTRWTMEMTFSLLPWKPLLVFTGTSVMGINPENGKFCSHLLRIYKTPDLETPKYQILKRTATYEVRKYSPFIIVETQSDMLAGSTGFNDVAGLPDPNKEAVGLRTVEGGFAAVLKFSGKPMDDIVREKEKLLRSSLLLDGLKPKDGCLLARYNDPGRTKSFMMRNEVLIWLEEFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN91</accession>
    <name>A0A103XN91_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_004215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004609">
        <property type="protein sequence ID" value="KVH93733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN91"/>
    <dbReference type="Gramene" id="KVH93733">
        <property type="protein sequence ID" value="KVH93733"/>
        <property type="gene ID" value="Ccrd_004215"/>
    </dbReference>
    <dbReference type="OMA" id="KIHEDYY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33743:SF33">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33743">
        <property type="entry name" value="PROTEIN GOLVEN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118945" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH93733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="190" mass="21374" checksum="2703B4FD8677BDFB" modified="2016-04-13" version="1">MKIYLMFTILVLSSLLTYKAQGIRLGKVTLSPSNHEDIVKISLVKGSSEDGQSLVQTAEISSGNTIKKRRLSCKAATKNSHDGHCLPKIHEDYYGPRHHPPRTNRKLMTKIISSKTTTIITKKSDEYKHDPEAEVQSTHGLIGKEETSSFNSLQNSKHWKTEVSTKHYPYDIDIAGMDYTPARKKSPVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP85</accession>
    <name>A0A103XP85_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione-disulfide reductase</fullName>
            <ecNumber evidence="4">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_003600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01004557">
        <property type="protein sequence ID" value="KVH94338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP85"/>
    <dbReference type="STRING" id="59895.A0A103XP85"/>
    <dbReference type="Gramene" id="KVH94338">
        <property type="protein sequence ID" value="KVH94338"/>
        <property type="gene ID" value="Ccrd_003600"/>
    </dbReference>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000051">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF9">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="94"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="14">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVH94338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="510" mass="55158" checksum="2D1C936148F23790" modified="2016-04-13" version="1">MATSLSTPKLSTTLSSSTLQTLLYRHKFSTQNHSPFIIFPQSLSSSSRYSSSFNLSKKALGFLSDHRRNAILKSRRFATRADSTNGAEPRYDYDLFTIGAGSGGVRASRFASNFGASVAVCELPFATISSDTTGGVGGTCVLRGCVPKKLLVYASKYSHEFEESLGFGWSYGSEPTHDWSTLMANKNAELQRLTVDVDGKLYTAKNILVSVGGRPFIPEIPGREYVIDSDAALDLPSKPTKIAIVGGGYIALEFAGIFNGLQSEVHVFIRQKKVLRGFDEEVRDFVAEQMSLKGIEFHPEESPQAVIKSSDGSFSLKTNKGTTEGFSHVMFATGRKPNTKNLGLETVGVKLDKNGAIEVDEYSRTSVPSIWAVGDVTDRMNLTPVALMEGGALAKTLFANEPTKPDFRYLFSQPPIGQVGLSEEQAIAAYGDINVFTANFRPLKATLSGLPDKVFMKLVVCAKTDQFDATIGVHPTSAEEFVTMRTPTRKIRNSPSGGKADSQAKAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPY1</accession>
    <name>A0A103XPY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_003340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with OEP61/TPR7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004544">
        <property type="protein sequence ID" value="KVH94604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPY1"/>
    <dbReference type="STRING" id="59895.A0A103XPY1"/>
    <dbReference type="Gramene" id="KVH94604">
        <property type="protein sequence ID" value="KVH94604"/>
        <property type="gene ID" value="Ccrd_003340"/>
    </dbReference>
    <dbReference type="OMA" id="LIPCTYI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000038">
        <property type="entry name" value="DnaJ protein ERDJ2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000007">
        <property type="entry name" value="DnaJ protein ERDJ2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF14">
        <property type="entry name" value="C2 DOMAIN, DNAJ DOMAIN, SEC63 DOMAIN, IMMUNOGLOBULIN E-SET-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="625"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH94604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="669" mass="75577" checksum="790889984FE47DFF" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ60</accession>
    <name>A0A103XQ60_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ60"/>
    <dbReference type="STRING" id="59895.A0A103XQ60"/>
    <dbReference type="Gramene" id="KVH94775">
        <property type="protein sequence ID" value="KVH94775"/>
        <property type="gene ID" value="Ccrd_003160"/>
    </dbReference>
    <dbReference type="OMA" id="HVEEWNP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019852">
        <property type="term" value="P:L-ascorbic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000035">
        <property type="entry name" value="Leucine rich repeat protein phosphatase 2c domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="377"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="644" mass="71252" checksum="6F7A89879BAF7FC9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQD5</accession>
    <name>A0A103XQD5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase AER61, uncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004481">
        <property type="protein sequence ID" value="KVH94966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQD5"/>
    <dbReference type="Gramene" id="KVH94966">
        <property type="protein sequence ID" value="KVH94966"/>
        <property type="gene ID" value="Ccrd_002965"/>
    </dbReference>
    <dbReference type="OMA" id="WITKYGN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF122">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 61 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="6">
        <location>
            <begin position="313"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH94966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="497" mass="56535" checksum="C27126CB93A82C8D" modified="2016-04-13" version="1">MVHYQRYIQLRKGVSMAAYVDEEDACVNMSGCNKKSKPKFLFFLLFCTLLSSCLLLAPFPTSTLSLLYPSRGEEETLSDAKTSLCSSVSNGTICCDRSSIRSDVCIMKGDIRTQSSSFSVFLYTSENSGAGKQPLRREKIRPYTRKWEPSTMATIDELTLISKKSNSSATGDQHSCDVNHDVPAVFFSTGGYTGNVYHEFNDGLIPLYITSQKYNKKVVFVILEYHDWWITKYGNILTHLSDYEPIDFNGDKRTHCFSEAIVGLRIHDELTVDPSLTEGSKSIKDFRDILDKGYRPRIQGLLLEEQSNNPIKQVARLEKPKLVIISRNGSRAILNENVLVKMAEKIGFTVTVLRPQRTTELARIYQALNSSDVMLGVHGAAMTHFLFMKPGSVFIQVVPLGTNWAAETYYGEPAKKLGLRYIGYEILPRESSLYEEYESNDPVLRDPNSVNDRGWEFTKKIYLDRQKVRLNLVRFRKRLVRSYIYTMSKRNGMDGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQE1</accession>
    <name>A0A103XQE1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004481">
        <property type="protein sequence ID" value="KVH94968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQE1"/>
    <dbReference type="STRING" id="59895.A0A103XQE1"/>
    <dbReference type="Gramene" id="KVH94968">
        <property type="protein sequence ID" value="KVH94968"/>
        <property type="gene ID" value="Ccrd_002961"/>
    </dbReference>
    <dbReference type="OMA" id="RMIMINI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF23">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="237" mass="27383" checksum="CC840A986F8B3D4B" modified="2016-04-13" version="1">MECLNTLQNIPEAIETAELVYFNRIPHQSRIPHFLIVSSVCHLPFFHPTICLLPTSAAISTTSQSEFTGMGFTPNEIREEIIRNPKILGSEVGEMSKCLRMLNSLKCRVPIKENLFSEGAFMASYEVKSRIDCLHKHGLLYRDAFSVLWREPRAILYDLKEIDLKMEFLTNTMKFDVLSLDEVPEYLGVHFEKQIVPRYNVIEHLRSKGGIGDEIGLRRMIMINILKDDVVMRRIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS67</accession>
    <name>A0A103XS67_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS67"/>
    <dbReference type="Gramene" id="KVH95883">
        <property type="protein sequence ID" value="KVH95883"/>
        <property type="gene ID" value="Ccrd_002049"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1936495at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34683:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34683">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="17036" checksum="D424AE1FFBC2A882" modified="2016-04-13" version="1">MGPTMADFYLPRKISESRVLFLLRRIYSSYTCSNFQHPSFPIYSLSLSLSLNKNSHFQKTPLHPIASTSLKLEIRSGFVPFTMKKPGFLAASMAAASAITGTNLKNQPSLQDHGSSSKLNEDSSPEKTNCCSEKFAPRFDGLRFIETLVTAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSS9</accession>
    <name>A0A103XSS9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004348">
        <property type="protein sequence ID" value="KVH96208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSS9"/>
    <dbReference type="Gramene" id="KVH96208">
        <property type="protein sequence ID" value="KVH96208"/>
        <property type="gene ID" value="Ccrd_001707"/>
    </dbReference>
    <dbReference type="OMA" id="ELRIKHW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46250:SF18">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="110" mass="12557" checksum="5B338E46372ACDEE" modified="2016-04-13" version="1">MADRRNWNIQEEDVLISILQEIVAAGGRSDNGCFRTGTYEQIVLKMREKIPGLNITSKHIQNKMKRLKDKYSAAYDMLNTSGFGWDDAHQCVTVDAQVLEEYLKSFGTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTP9</accession>
    <name>A0A103XTP9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004246">
        <property type="protein sequence ID" value="KVH96711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTP9"/>
    <dbReference type="STRING" id="59895.A0A103XTP9"/>
    <dbReference type="Gramene" id="KVH96711">
        <property type="protein sequence ID" value="KVH96711"/>
        <property type="gene ID" value="Ccrd_001198"/>
    </dbReference>
    <dbReference type="OMA" id="EMEGFSM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000007">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044825">
        <property type="entry name" value="GLK1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31312">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR GLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31312:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR GLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="349" mass="38413" checksum="0021FA127C4743B1" modified="2016-04-13" version="1">MLAVVSPLENNTTRDGRDQGAEMVGFSVGDDFPDFSDDNLLESIDFDDLFEGMDDRDMLPDLEMDPELLAGEFSLSGGEADSSEFNNNSVTSFSGEQKLEDLISRKEEEVSKRDERNEAVATNPARKESDRGRKSSSDKSKNSSQGKRKVKVDWTPELHRRFVQAVEQLGVDKAVPSRILEIMGIGCLTRHNIASHLQKYRSHRKHLLAREAEAASWSQRRQMYGGNTTIGGGGGGSGGGGGKRDMGPWVAPPTMGFPPMTPLPHYRPLHVWGHPSMDRPLMPVWPKHITSLPPTPPPPHSKESIDAAIGDILSKPWQPLPLGLKPPALDSVMVELQRQGIQKIPPTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUR6</accession>
    <name>A0A103XUR6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_000673</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of at least 49 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003848">
        <property type="protein sequence ID" value="KVH97228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUR6"/>
    <dbReference type="STRING" id="59895.A0A103XUR6"/>
    <dbReference type="Gramene" id="KVH97228">
        <property type="protein sequence ID" value="KVH97228"/>
        <property type="gene ID" value="Ccrd_000673"/>
    </dbReference>
    <dbReference type="OMA" id="FMSSHDD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 17" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH97228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="127" mass="14187" checksum="7914B748AF0B0367" modified="2016-04-13" version="1">MASALRAAILGHVRVPVVANGSKLLTPLWIHRTTSVRSMSSHDDHLEKSQVIDRILDIVKSFPKVDPSKVTPEVHFQKDLGLDSLDNVELIMAIEEEFKLEIPDKEADKIDSCALAIEYVYNHPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVF6</accession>
    <name>A0A103XVF6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="5 11">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 11"/>
    <dbReference type="EMBL" id="LEKV01003824">
        <property type="protein sequence ID" value="KVH97611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVF6"/>
    <dbReference type="STRING" id="59895.A0A103XVF6"/>
    <dbReference type="Gramene" id="KVH97611">
        <property type="protein sequence ID" value="KVH97611"/>
        <property type="gene ID" value="Ccrd_000262"/>
    </dbReference>
    <dbReference type="OMA" id="NKPWKLS"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000052">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="392" mass="42570" checksum="11B07E23FCE7C5BB" modified="2016-04-13" version="1">MASASFVKLNASSSPWIGQRSFDQRPGSSSRLPATRVSVVRAGSYSEELVKTAKTIASPGRGILAIDESNATCGKRLASIGLDNTEANRQAYRQLLLTTPGLGQYISGSILFEETLYQSTTDGKKMVDCLREQNIVPGIKVDKGLVPLPGSNNESWCQGLDGLASRSAEYYSQGARFAKWRTVVSVPCGPSALAVKEAAWGLARYAAISQDNGLVPIVEPEILLDGDHPIERTLEVAERVWSEVFYYLAENNVMFEGILLKPSMVTPGADHKEKASPETVAKYTLTMLKRRVPPAVPGIMFLSGGQSEMEATLNLHAMNQSPNPWHVSFSYARALQNSVLKTWQGRPENVEAGQKALLSRAKANSLAQLGKYSADGESDDAKKGMFVKGYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y023</accession>
    <name>A0A103Y023_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase Ccrd_021713</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y023"/>
    <dbReference type="STRING" id="59895.A0A103Y023"/>
    <dbReference type="Gramene" id="KVI00044">
        <property type="protein sequence ID" value="KVI00044"/>
        <property type="gene ID" value="Ccrd_021713"/>
    </dbReference>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="238" mass="27109" checksum="D44050752D6E4CCC" modified="2016-04-13" version="1">MEQVSDRNAGTADDDDTPMLSSHALEALREFLSEQNSSLTADNDGATVAEEDKVVALVTEDWRLSQFWYDRETAETVAREVHALYTSMDSPPSVACIACPTLYVYLKKMHHNLPVQLLEYDNRFKQYGSEFTFYDYNQPLELPSSMKHAFRIIIADPPYLSIASNHHWMNRPFMLAGYASSLAFPVWTCAVQQDRAAELLGLRPCGFRPQHSSKLGNEFRLFTNYDPGLRLGGWEQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0P5</accession>
    <name>A0A103Y0P5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_021385</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0P5"/>
    <dbReference type="STRING" id="59895.A0A103Y0P5"/>
    <dbReference type="Gramene" id="KVI00365">
        <property type="protein sequence ID" value="KVI00365"/>
        <property type="gene ID" value="Ccrd_021385"/>
    </dbReference>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="128"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="452"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="569"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="681"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVI00365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="800" mass="88097" checksum="1FEF32FC287E824B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0W0</accession>
    <name>A0A103Y0W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanosine nucleotide diphosphate dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003388">
        <property type="protein sequence ID" value="KVI00458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0W0"/>
    <dbReference type="STRING" id="59895.A0A103Y0W0"/>
    <dbReference type="Gramene" id="KVI00458">
        <property type="protein sequence ID" value="KVI00458"/>
        <property type="gene ID" value="Ccrd_021295"/>
    </dbReference>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000010">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.519.10:FF:000015">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000587">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI00458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="49801" checksum="FEEA32D7AB8DF4FE" modified="2016-04-13" version="1">MDEEYDVVVLGTGLKECILSGLLSVDGLKVLHMDRNDYYGGESTSLNLIQLWKKFRGSDKPPAHLGSSRDYNVDMIPKFIMANGALVRVLIHTDVTKYLYFKAVDGSFVYNKGKVHKVPATDMEALKSPLMGIFEKRRARKFFIYVQDYNENEPKTHEGMDLTRVTTRELIAKYGLDDNTVDFIGHALALHRDDRYLNEPALETVKKMKLYAESLARFQGGSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFDDEGKVCGVTSEGETAKCKKVVCDPSYLPNKVRKVGKVARAICIMSHPIPNTNDSHSVQVILPQKQLGRRSDMYLFCCSYSHNVAPKGKFIAFVSTEAETDQPEIELKPGLDLLGPVDEIFFDVYDRYEPVNEPSLDNCFISTSYDATTHFESTVIDVLNMYSMITGKVLDLNVDLSAASAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1A4</accession>
    <name>A0A103Y1A4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ motif, EF-hand binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003359">
        <property type="protein sequence ID" value="KVI00670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1A4"/>
    <dbReference type="STRING" id="59895.A0A103Y1A4"/>
    <dbReference type="Gramene" id="KVI00670">
        <property type="protein sequence ID" value="KVI00670"/>
        <property type="gene ID" value="Ccrd_021081"/>
    </dbReference>
    <dbReference type="OMA" id="WIEWRIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="308" mass="36677" checksum="1D48A6A055FCC28B" modified="2016-04-13" version="1">MAAFSTLELMLHEVQNQEHIGHHETMPVLPQRPLSKARIPSKRARRAALSFHSQHFRSEIEEFVDGKSRRDGFAFLDGHGGRVLSKDDVKNKEEKAEKGIIVIQKFVRGENARRDFRKIAKMLIEENVNREFVWKPLRDRETTIVYMQSEVLRSEAALQDKKRENAILELRIQHIDKKWELHKAKMNLKEKSWQDELTSIQMSLVSARERTTDEITDHLPRNPTRQQEIGKMDLTIREILELQENDMETDCGFRLKSRKCQEHEFKKLKCRFKAWQKDFKARLHVRRRVDGFDDDCRTQRVHKRCWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1A7</accession>
    <name>A0A103Y1A7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Late embryogenesis abundant protein, LEA-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005443</name>
        <name evidence="6" type="ORF">Ccrd_021044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004815">
        <property type="protein sequence ID" value="KVH92495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LEKV01003349">
        <property type="protein sequence ID" value="KVI00704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1A7"/>
    <dbReference type="STRING" id="59895.A0A103Y1A7"/>
    <dbReference type="Gramene" id="KVH92495">
        <property type="protein sequence ID" value="KVH92495"/>
        <property type="gene ID" value="Ccrd_005443"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI00704">
        <property type="protein sequence ID" value="KVI00704"/>
        <property type="gene ID" value="Ccrd_021044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23708" checksum="7B6959730582687E" modified="2016-04-13" version="1" fragment="single">MSMHAKTDSEVTSQTASSPTRSPRRPVYFVQSPSRDSHDGEKTTNSFHSTPVLSPNGSPGRHSRNSSSTRFSGSLRPGSRKGSSHHHHQQVRKGEKGFDAIEEEGLIDDDHRRGIPRRCYFLAFVVGFFVLFTFFALVLWAAARPQKPVITMRSISFDQFVVNAGADASGVATEMVNLNVTIKFNFRNRGTFFGVHVSSTPIDLAYTELTLASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1V5</accession>
    <name>A0A103Y1V5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_020752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003150">
        <property type="protein sequence ID" value="KVI00984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1V5"/>
    <dbReference type="Gramene" id="KVI00984">
        <property type="protein sequence ID" value="KVI00984"/>
        <property type="gene ID" value="Ccrd_020752"/>
    </dbReference>
    <dbReference type="OMA" id="EVEQRIC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF837">
        <property type="entry name" value="OXOGLUTARATE_IRON-DEPENDENT DIOXYGENASE, NON-HEME DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI00984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="38371" checksum="AC0F25762A2F78E3" modified="2016-04-13" version="1">MFDHLMAPPPLTDPHELKAFVVDEGHGVKGLAELKIKSLPALFIQPLEKRLDMSKVVPHESIPVIDMSNSEDPEVEQRICDAAENWGFFQIVNHGVPASVLEDVKEATRRFFDLRADEKKKYLFKNSRTKNVRLVTSFIPEVDKVLEWKDYLSCFYSESLIKRLLEVLMKRLGISELNETNEPILKGSRRINLNYYPVCPNPELTVGVGGHSDVSTLTVLLQDEIGGLYVRKLHSENWVHVPPIKGCLTINIGDALQIMSNGRYKSIEHQVVANGHENRISVPIFVNPRPSDVIGPLRETMRRGEKGLYKQVLYSDYVKHFYRKSHNGKDTIDFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1W0</accession>
    <name>A0A103Y1W0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_020745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003149">
        <property type="protein sequence ID" value="KVI00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1W0"/>
    <dbReference type="STRING" id="59895.A0A103Y1W0"/>
    <dbReference type="Gramene" id="KVI00989">
        <property type="protein sequence ID" value="KVI00989"/>
        <property type="gene ID" value="Ccrd_020745"/>
    </dbReference>
    <dbReference type="OMA" id="EYDIKSF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000184">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119308" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="29705" checksum="E37B5D7CC9D0AE1A" modified="2016-04-13" version="1" fragment="single">MVSFGILIVLFLFSLVALSFVGGLCITVDSKEPSHSKEFVLTLDQSNFTETIGKHNFVVVEFYAPWCGHCKDLAPEYEKAACILSNNGSPVVVAKVDVNDEKNKDVAIEYDIKSFPTLKLIRDGGKRVQDYKGPRDAQGIVAYLKKQSGPASAQIKSTEDATHLIDGDEIVIFEAFSTLAENLRSNYEFAHTLNAKLLPRGDSTVSGPIVQTFIEEATIPSVTLFNKDPKNHPSKPFGAFESKYHDIANEHKGKGMSFLMADVEATHAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y242</accession>
    <name>A0A103Y242_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">Ccrd_020637</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003131">
        <property type="protein sequence ID" value="KVI01106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI01106">
        <property type="protein sequence ID" value="KVI01106"/>
        <property type="gene ID" value="Ccrd_020637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000468">
        <property type="entry name" value="LysM receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000468">
        <property type="entry name" value="PTI1-like tyrosine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057097">
        <property type="entry name" value="LysM_RLK3/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF37">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE JMJ26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23577">
        <property type="entry name" value="LysM_RLK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="31">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="489"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="29">
        <location>
            <begin position="1063"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="30">
        <location>
            <begin position="1483"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="821"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="912"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1006"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1588"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="915"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="1598"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KVI01106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1822" mass="206148" checksum="A9423101B700BE74" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y308</accession>
    <name>A0A103Y308_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Activating signal cointegrator 1 third domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_020141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003008">
        <property type="protein sequence ID" value="KVI01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y308"/>
    <dbReference type="STRING" id="59895.A0A103Y308"/>
    <dbReference type="Gramene" id="KVI01584">
        <property type="protein sequence ID" value="KVI01584"/>
        <property type="gene ID" value="Ccrd_020141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="142" mass="16326" checksum="08698318CDEA5838" modified="2016-04-13" version="1" fragment="single">AEAYAKRLVDYDRNSAARTTVIDDQSDHYEIEGNSWLSMEENELLRKKRVAYAVALDTETQKQAAAEAYAKRLVDYDRNSAARTTVIDDQSDHYEIEGNSWLSMEENELLRKKRVAYAVALDTETQKQVEENAVKHFFAISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3N4</accession>
    <name>A0A103Y3N4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002671">
        <property type="protein sequence ID" value="KVI01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3N4"/>
    <dbReference type="Gramene" id="KVI01943">
        <property type="protein sequence ID" value="KVI01943"/>
        <property type="gene ID" value="Ccrd_019775"/>
    </dbReference>
    <dbReference type="OMA" id="EDSAKDC"/>
    <dbReference type="OrthoDB" id="1104553at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044678">
        <property type="entry name" value="COR27/28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33676">
        <property type="entry name" value="COLD REGULATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33676:SF3">
        <property type="entry name" value="COLD-REGULATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="235" mass="26265" checksum="9A54AE34EC5A5FB0" modified="2016-04-13" version="1">MEESRRRDSSSLPVLTDLTVDENFGPSSPSDSDSYSSLIVENSKGRLQQIEDSAKDCLTAWTDEKHDMYLDHLESSFVEQLHQSIGVLAWCSEHDSKGPYFSQKLHAKTRNTSQMLKMIQDDCSEKIDLKRSQPLLNCTSDSLVLLKSRPRCAGKQRFARAAKLQDSSASRNLCIEDKLLFNEAGICSEQIAARHGKPVDCAGEFSDQNFADEASSEQMCITTMSKRSKTIVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4V0</accession>
    <name>A0A103Y4V0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4V0"/>
    <dbReference type="STRING" id="59895.A0A103Y4V0"/>
    <dbReference type="Gramene" id="KVI02542">
        <property type="protein sequence ID" value="KVI02542"/>
        <property type="gene ID" value="Ccrd_019279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10388" checksum="307EE93980BC119B" modified="2016-04-13" version="1">MSGAAQSFSGNLKKAVAGIRRINLDGLRWRVFDAKGQVLGRLASQISTVVQGKDKPTYTPNRDDGDMCIVLNAKDICVTGRKLTDKYYRIEIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y520</accession>
    <name>A0A103Y520_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen V5/Tpx-1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002648">
        <property type="protein sequence ID" value="KVI02646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y520"/>
    <dbReference type="Gramene" id="KVI02646">
        <property type="protein sequence ID" value="KVI02646"/>
        <property type="gene ID" value="Ccrd_019072"/>
    </dbReference>
    <dbReference type="OMA" id="RYQRDKM"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05381">
        <property type="entry name" value="CAP_PR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000004">
        <property type="entry name" value="CAP, cysteine-rich secretory protein, antigen 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119398" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="167" mass="18606" checksum="AC30C011F400A487" modified="2016-04-13" version="1">MNKLLLVLTLLLWRAAAQAPPPPAVPADGKEYLDAHNKARAEVGVSPLRWNFQLAKATSLLVRFQRDRENCRFANLTSGKYGGNQMWASQEVVTPARVVENWVSEKAYYSYANNSCAANHRCGVYTQVVWRHSEELGCSLARCAQDQSTLAICFYNPPGNVIGESPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5T6</accession>
    <name>A0A103Y5T6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate-induced protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EXORDIUM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002571">
        <property type="protein sequence ID" value="KVI03074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5T6"/>
    <dbReference type="Gramene" id="KVI03074">
        <property type="protein sequence ID" value="KVI03074"/>
        <property type="gene ID" value="Ccrd_018636"/>
    </dbReference>
    <dbReference type="OMA" id="YPFAWPN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF18">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119417" evidence="6">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="328" mass="36170" checksum="7035179DF27325F2" modified="2016-04-13" version="1">MLHSCHLLFICFSFLARFSNAQSNQFKGTKNYEGSSNLLDLQYHMGPILTSPINLYIIWYGNWNPKDQSTIKDFLYSLSSSSSVSPSTFDWWQTVRLYTDQTGSNITESISLSGEFIDSRYSHGKFLTRLSIQSVIKSSLDTLYRPLPLNYNNGLYLVLTSSDVQVQDFCRAVCGFHYFTFSSIVGATLPYAWVGDSGAQCPGVCAYPFAWPKYSGMPSGNKNIMGAPNGDPGIEGMISVIAHELAEVSTNPFVNAWYAGNDPSAPDEIADLCVGVYGSGAGGGFVGHVYKDKMGNGYNLNGVKGRRFLVQWVWDPIKRSCFGPNAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8C5</accession>
    <name>A0A103Y8C5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family. HKT (TC 2.A.38.3) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002193">
        <property type="protein sequence ID" value="KVI04372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y8C5"/>
    <dbReference type="Gramene" id="KVI04372">
        <property type="protein sequence ID" value="KVI04372"/>
        <property type="gene ID" value="Ccrd_017315"/>
    </dbReference>
    <dbReference type="OMA" id="QMELAGF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="40008" checksum="179B045B4AB9B031" modified="2016-04-13" version="1">MMIAPTIFVRNTYLCSFLHALLLRVDLLWLQLYYYATLFVLGFFVLANLEPRDPLHRPKNYDLFFTTVSAATVSSMATVEMEVFSNTQLFILAILMFLGGEVFTSMLELQFKKFKLLETKKTHFNSNGCTDLENDLNSLKTNTDLKYNSMKLLGFIILFYILTVHISAFLLVSLYISLVPLAKEVTNSKGVSIPVFSTVTIISTFSNGGFLPTNEGMMVFKKDLGLLLILIPLVLLGNTLYPVILRVILLILGKVSKREELEYILKNHSXMGYNHLLSGVRCRFLVLTSIGFISIQFILLIIMEWKSDIMEGLNPXEKVVGSLFQVVNTRHAGESVFDLSLLSPAIIVLFITMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y9S0</accession>
    <name>A0A103Y9S0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ-containing protein, X-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001889">
        <property type="protein sequence ID" value="KVI05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y9S0"/>
    <dbReference type="STRING" id="59895.A0A103Y9S0"/>
    <dbReference type="Gramene" id="KVI05126">
        <property type="protein sequence ID" value="KVI05126"/>
        <property type="gene ID" value="Ccrd_016556"/>
    </dbReference>
    <dbReference type="OMA" id="DEQFKHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF17">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="38161" checksum="4119E77D9A782653" modified="2016-04-13" version="1">MVKETEYYDVLGVKPTATEAEIKKAYYIKVLGEAYQVLSNPDQKQAYDAYGKSGISTEAIIDPAAIFAMLFGSELFEDYIGQLAMASMASMDIFTEGEQFDAKKLQEKMKIVQKEREEKLIQTLKDRLIPYVQGNKEEFVRHAEAEVSRLSNAAYGVDMLNTIGYIYVRQAAKELGKKAIYLGVPFIAEWFRNKGHFIKSQVTAATGALALIQLQEDMKRQLSAEGKYTEEELEEYMQSHKKLMIDSLWKLNVADIEGTLSRVCQMKAKSANGDESETILNSGGVHNLNGGDPDHASRAAESGQSSQTSIAPQSPYVEAPHFAGVENFHFPMPTAPPGAQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBL2</accession>
    <name>A0A103YBL2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBL2"/>
    <dbReference type="STRING" id="59895.A0A103YBL2"/>
    <dbReference type="Gramene" id="KVI06085">
        <property type="protein sequence ID" value="KVI06085"/>
        <property type="gene ID" value="Ccrd_015598"/>
    </dbReference>
    <dbReference type="OMA" id="ENEWVEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31549:SF277">
        <property type="entry name" value="OS08G0167400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31549">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF247)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="523" mass="59697" checksum="6EF3057FEE9676B0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YC98</accession>
    <name>A0A103YC98_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YC98"/>
    <dbReference type="STRING" id="59895.A0A103YC98"/>
    <dbReference type="Gramene" id="KVI06479">
        <property type="protein sequence ID" value="KVI06479"/>
        <property type="gene ID" value="Ccrd_015181"/>
    </dbReference>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="424"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="693"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="939" mass="102833" checksum="93E31EC02CC4498E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCD7</accession>
    <name>A0A103YCD7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase/kelch, beta-propeller</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001812">
        <property type="protein sequence ID" value="KVI06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YCD7"/>
    <dbReference type="Gramene" id="KVI06514">
        <property type="protein sequence ID" value="KVI06514"/>
        <property type="gene ID" value="Ccrd_015136"/>
    </dbReference>
    <dbReference type="OMA" id="LLEPRMM"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF79">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119593" description="Galactose oxidase/kelch, beta-propeller" evidence="2">
        <location>
            <begin position="29"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="435"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59672" checksum="22EBCD4F6CF56636" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCG6</accession>
    <name>A0A103YCG6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_015088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001797">
        <property type="protein sequence ID" value="KVI06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCG6"/>
    <dbReference type="STRING" id="59895.A0A103YCG6"/>
    <dbReference type="Gramene" id="KVI06563">
        <property type="protein sequence ID" value="KVI06563"/>
        <property type="gene ID" value="Ccrd_015088"/>
    </dbReference>
    <dbReference type="OMA" id="RWSNIAK"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048262">
        <property type="term" value="P:determination of dorsal/ventral asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044636">
        <property type="entry name" value="RADIALIS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952:SF60">
        <property type="entry name" value="PROTEIN RADIALIS-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="10201" checksum="9C9BD3D155326E9E" modified="2016-04-13" version="1">MTSNSTWRQNKLFENALAIYDKDTPDRWQNIAKATGKTVEEVKRQYQLLVDDVEQIESDKVPLPSYKTSGTKASYQLEKRLKYLKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCP7</accession>
    <name>A0A103YCP7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_014979</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01001769">
        <property type="protein sequence ID" value="KVI06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCP7"/>
    <dbReference type="STRING" id="59895.A0A103YCP7"/>
    <dbReference type="Gramene" id="KVI06669">
        <property type="protein sequence ID" value="KVI06669"/>
        <property type="gene ID" value="Ccrd_014979"/>
    </dbReference>
    <dbReference type="OMA" id="HHDEMKE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000173">
        <property type="entry name" value="Probable serine/threonine-protein kinase At1g01540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052232">
        <property type="entry name" value="RLK_Ser/Thr-Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984:SF11">
        <property type="entry name" value="TELOKIN_MYOSIN LIGHT CHAIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="176"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="459" mass="51452" checksum="DC6C460DC62F48C2" modified="2016-04-13" version="1">MSDSFKDELSRKTSIFGLRFWVVLGICFGAAIVIAMFFISLYFTSKRKHSFKKTKTICHKPTIPTISDDIQEPRVDPTRTHDIETHDNQKHQQPQVEEEEGENPSIESGSLAIVRSHAAVNDGNLNGYKKIQIEIGKAGGGSGDQLSIISVQPEVSHLGWGHWYTLRELEIATNGFADENVIGEGGYGIVYSGVLMDNTMVAVKNLLNNRGQAEKEFKVEVEAIGRVRHKNLVRLLGYCAEGAQRILVYEYVNNGNLEQWLHGDVGPISPLTWEIRMNIVLGTAKGLTYLHEGLEPKVVHRDIKSSNILLDRQWLPKVSDFGLAKLLGSEKSYVTTRRSDVYSFGILIMEIISGRNPVDYSRPAEEVNLVDWLKTMVTNRNAEGVLDPKLPERPSSRALKRALLVALRCVDPSAQKRPKMGHEHRGNREIGRERLMEKRYFESGDSSGCESSRAHGMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCQ7</accession>
    <name>A0A103YCQ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actinidain</fullName>
            <ecNumber evidence="9">3.4.22.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_014958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cysteine protease responsible for the cleavage of kiwellin into kissper and KiTH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Specificity close to that of papain.</text>
            <dbReference type="EC" id="3.4.22.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.14" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01001764">
        <property type="protein sequence ID" value="KVI06687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCQ7"/>
    <dbReference type="STRING" id="59895.A0A103YCQ7"/>
    <dbReference type="Gramene" id="KVI06687">
        <property type="protein sequence ID" value="KVI06687"/>
        <property type="gene ID" value="Ccrd_014958"/>
    </dbReference>
    <dbReference type="OMA" id="CIYEYAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.160:FF:000002">
        <property type="entry name" value="Cysteine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000068">
        <property type="entry name" value="Cysteine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018648448" description="Actinidain" evidence="11">
        <location>
            <begin position="21"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="14">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="13">
        <location>
            <begin position="135"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="12">
        <location>
            <begin position="373"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI06687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="442" mass="48814" checksum="7C7DE2FFAE60349D" modified="2016-04-13" version="1">MKLLSMAALLLFALFSVSSAMDMSIIGYDATHMTTNWRTDDEVNAMYESWLLKHGKTYNALGEKDRRFQIFKDNLRFIDDHNSGDHTYKLGLNKFADLTNEEYRSTYTGIKTIDAKRKQPKVKSDRYALRSGEALPESVDWREKGAITGVKDQGSCGSCWAFSTTGSVEGINQIVTGDLISVSEQELVDCDTSYNEGCNGGLMDYAFEFIINNGGIDTEEDYPYTGRDGKCDTYRKNAKVVSIDGYEDVPVNDESALQKAVANQPIAVAIEAGGRDFQFYTSGIFTGQCGTALDHGVLAVGYGSENGKDYWIVKNSWGDAWGESGFLKMERNIKDSVGKCGIAMEASYAVKTGQNPPNPGPSPPSPVTPETVCDEYSTCPEGTTCCCVYEYYGYCFAWGCCPLEGASCCEDHYSCCPHDYPICNVRRGTCSKMKEDYVFLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFF8</accession>
    <name>A0A103YFF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001314">
        <property type="protein sequence ID" value="KVI08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFF8"/>
    <dbReference type="Gramene" id="KVI08095">
        <property type="protein sequence ID" value="KVI08095"/>
        <property type="gene ID" value="Ccrd_013538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24578" checksum="6B0F12C68DCDACCF" modified="2016-04-13" version="1" fragment="single">MGYEKKKKESKFSNTAENPVDVEDESNEVAILNVSQAKQRATDCSTRRETICKKPPKSREDSKDDDDFEVQDQNIRKKVKSVKGDTKGREDNVKGTIKTHLPLRTRTSPKPLYTMIQNLSPPQIECVKEMGFEGMLNMKTDGIPAKLGYYVVDSFDSQNMLIKLENGVIPITVKKIHEMIGAPIGGAPLDSLVNDNCGVSIVEQWKSRYSKLSLRVTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGL5</accession>
    <name>A0A103YGL5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001092">
        <property type="protein sequence ID" value="KVI08736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGL5"/>
    <dbReference type="STRING" id="59895.A0A103YGL5"/>
    <dbReference type="Gramene" id="KVI08736">
        <property type="protein sequence ID" value="KVI08736"/>
        <property type="gene ID" value="Ccrd_012896"/>
    </dbReference>
    <dbReference type="OMA" id="TNRPRFY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="131"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="606" mass="69678" checksum="A6F934881619C557" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGQ5</accession>
    <name>A0A103YGQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001091">
        <property type="protein sequence ID" value="KVI08767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGQ5"/>
    <dbReference type="Gramene" id="KVI08767">
        <property type="protein sequence ID" value="KVI08767"/>
        <property type="gene ID" value="Ccrd_012882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="85" mass="10096" checksum="70135465AD8CD8D0" modified="2016-04-13" version="1">MQLVSSRTRENDDQESLETRNNCLKQILMSISSNPNYEPTRQNSFEAEQGVTGTPAFPGFWYWYEDFVEPRYEDEWIVDLTCYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHE8</accession>
    <name>A0A103YHE8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHE8"/>
    <dbReference type="STRING" id="59895.A0A103YHE8"/>
    <dbReference type="Gramene" id="KVI09154">
        <property type="protein sequence ID" value="KVI09154"/>
        <property type="gene ID" value="Ccrd_012514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="183" mass="20339" checksum="8EA8634A49D37EA2" modified="2016-04-13" version="1" fragment="single">MATMGSLAFVNDHTTIETAALLNNHHRPKFPLFAYYRPRKSLLDKTFVCNNSNVAVGGRVWRIKATGEKSSGGDATGDTDEALQAVIQKSKKLLAKQRDLLQQIAERRDIITSINNTTINSEIEEISSKEEESFLELDSNLPDDNYTADNPSSSSVDPVKYPLPDNLHYDEEASESGINLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHW1</accession>
    <name>A0A103YHW1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stigma-specific protein Stig1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001063">
        <property type="protein sequence ID" value="KVI09368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHW1"/>
    <dbReference type="Gramene" id="KVI09368">
        <property type="protein sequence ID" value="KVI09368"/>
        <property type="gene ID" value="Ccrd_012236"/>
    </dbReference>
    <dbReference type="OMA" id="VAPDCCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227:SF21">
        <property type="entry name" value="F12F1.21 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119728" evidence="3">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="18187" checksum="ED8C84D8F1602907" modified="2016-04-13" version="1">MGLLMVLFALSLSIIPFSASVSDNEVIHDLELSHTNPRTNLETQLLALNPFYQCDIYPRVCRAKNGVAPDCCKKKCVNVDTDRLNCGYCGKKCTSNEGCCKQKCVNMLTDRLNCGFCGMKCKYNESCCRGKCKNTYVDKRNCGVCQNKCKDGETCDYGMCNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI47</accession>
    <name>A0A103YI47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_012140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001060">
        <property type="protein sequence ID" value="KVI09488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI47"/>
    <dbReference type="STRING" id="59895.A0A103YI47"/>
    <dbReference type="Gramene" id="KVI09488">
        <property type="protein sequence ID" value="KVI09488"/>
        <property type="gene ID" value="Ccrd_012140"/>
    </dbReference>
    <dbReference type="OMA" id="PPAEKYW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055280">
        <property type="entry name" value="TIC32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48476">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE TIC 32, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48476:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE TIC 32, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="296" mass="32877" checksum="BBE3A1ACE66BA90F" modified="2016-04-13" version="1">MKKLNKGYVVVHAGGASGIGLETARVLALRGAHVIIAARNMKAANEAKQLMLTQNENAKIDVLELDLSSLNSIKAFADSFKALNLPLNLLINNAGVMFCPFQLSQDGIEMQFATNHLGHFYLTNLLLDKMKETATDTGIEGRIVNLSSVAHLYTYEYGIGFDKINDKDGYSDKKAYGQSKLANILHANELSRRLKEEGANITVNSVHPGLIMTDLMRHSFQLMRFLKLFTYLLWKNVQQGAATTCYVALHPKLKGVSGKYFVDCNEYPASNFATDPELAKKLWDYSNNLVNSLQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIR7</accession>
    <name>A0A103YIR7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, AAA-type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_011752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001038">
        <property type="protein sequence ID" value="KVI09876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIR7"/>
    <dbReference type="STRING" id="59895.A0A103YIR7"/>
    <dbReference type="Gramene" id="KVI09876">
        <property type="protein sequence ID" value="KVI09876"/>
        <property type="gene ID" value="Ccrd_011752"/>
    </dbReference>
    <dbReference type="OMA" id="GICRGIF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046863">
        <property type="term" value="F:ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1070:FF:000001">
        <property type="entry name" value="Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044960">
        <property type="entry name" value="RCA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048571">
        <property type="entry name" value="RuBisCO_activase_AAA_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429:SF44">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE_OXYGENASE ACTIVASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21228">
        <property type="entry name" value="RuBisCO_activase_AAA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribulose bisphosphate carboxylase/oxygenase activase AAA helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="38736" checksum="413D3F1EE167693F" modified="2016-04-13" version="1">MAAAVSTFGVAVNRAPLSLNGSSGVAAVPSSTFLGSSLKKIVNSRFTNINSNKYSSFKILAAEKEIEETQQTDKDKWKGLAYDISDDQQDITRGKGMVDSLFQAPQDAGTHFAVMSSYEYISTGLKTYNLDNNMGGFYIAPAFMDKLVVHITKNFLTLPNIKVPLILGVWGGKGQGKSFQCELVFAKMGITPIMMSAGELESGNAGEPAKLIRQRYREAADIIKKGKMCCLFINDLDAGADSDIVKLVDTFPGQSIDFFGALRARVYDDEVRNWIGGVGVEGIGKKLVNSREGPPTFEQPKMTIEKLLEYGNMLVQEQDNVKRVQLAETYLATAALGDANKDSIDRGSFFGKKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIS3</accession>
    <name>A0A103YIS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein ACR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein ACT DOMAIN REPEATS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds amino acids.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001042">
        <property type="protein sequence ID" value="KVI09820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIS3"/>
    <dbReference type="STRING" id="59895.A0A103YIS3"/>
    <dbReference type="Gramene" id="KVI09820">
        <property type="protein sequence ID" value="KVI09820"/>
        <property type="gene ID" value="Ccrd_011800"/>
    </dbReference>
    <dbReference type="OMA" id="PEYGHLQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040217">
        <property type="entry name" value="ACR1-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056816">
        <property type="entry name" value="ACR2/9/10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056805">
        <property type="entry name" value="ACT_ACR9/10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096:SF65">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24914">
        <property type="entry name" value="ACR10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24931">
        <property type="entry name" value="ACT_ACR9_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24926">
        <property type="entry name" value="ACT_ACR9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="51342" checksum="1979200C38405377" modified="2016-04-13" version="1" fragment="single">GNEVNLHLPNHQPNLPCLRLWPISRRRSSNRMKRMGMSWEDVVLIEGGKTSTDPTVVTVNCPDKAGLGCDLLRIVLEFGLYVTRGDFSTDGKWCYIVLWVVPRPSSLRVDWESLNKRLLSCCPSCLPTFYLNQLSDCSKPPQLYLLKVFSLDRKGLIHDVTKVLCELELAIQRVKVMTTPDGKVLDLFFITDGMDLLHTNIRREKTCEHLRVVLGECCISCELQLAGPEYDIQQGLSCISEAVAEELFSCELSAKEDRAQTLSADVSKVKKASITVDNLLSPTHTLLQIQCLDQKGLVYDILKISKDCDIRIVHGRISSSVKGYRSLDLFIQKKDGKKIVDNDNQVALCSRLKEEMLHPLRVIITNRGPDTELLVANPVELSGKGRPRVFYDVTLALKTLGICVFSAEIGRHSTPLRQWEVYRFLLDESRGFPLTSNRAKRDIVDKVRRTLMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YK27</accession>
    <name>A0A103YK27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001014">
        <property type="protein sequence ID" value="KVI10544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YK27"/>
    <dbReference type="Gramene" id="KVI10544">
        <property type="protein sequence ID" value="KVI10544"/>
        <property type="gene ID" value="Ccrd_011057"/>
    </dbReference>
    <dbReference type="OMA" id="IKIRECI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI10544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="234" mass="27029" checksum="9A075855B34BF223" modified="2016-04-13" version="1" fragment="single">ISLAVGTWSSPENVEYLCLTANYIDEHWKLQKKLLNFLTLDSSQTEDALSELVIKCLMDWDVDRKLFSMTLDDCFTYDDIASRTKEWVLQNRHLLKNGDLYDMRCASHLVKSLLQDAMEALKGVTEKIRESIRHAKSSLTTQGKLDEFAQQVGINTEKRLFVDNPLRWNSTYLMLEAALGYRGAFYLLQEHDSTYTTVLSEEEWQWASSVTSYMKLLVEIRVARASPLYPLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMC6</accession>
    <name>A0A103YMC6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_009765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000036">
        <property type="protein sequence ID" value="KVI11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YMC6"/>
    <dbReference type="Gramene" id="KVI11825">
        <property type="protein sequence ID" value="KVI11825"/>
        <property type="gene ID" value="Ccrd_009765"/>
    </dbReference>
    <dbReference type="OMA" id="PCGARHK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000384">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="40"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="477"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="789" mass="89509" checksum="CEC35AED173287F8" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRP6</accession>
    <name>A0A118JRP6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase fold protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006097">
        <property type="protein sequence ID" value="KVH87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRP6"/>
    <dbReference type="STRING" id="59895.A0A118JRP6"/>
    <dbReference type="ESTHER" id="cyncs-a0a118jrp6">
        <property type="family name" value="Duf_1350"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH87537">
        <property type="protein sequence ID" value="KVH87537"/>
        <property type="gene ID" value="Ccrd_025185"/>
    </dbReference>
    <dbReference type="OMA" id="VYDQEAM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010765">
        <property type="entry name" value="DUF1350"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127:SF3">
        <property type="entry name" value="INITIATION FACTOR 4F SUBUNIT (DUF1350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127">
        <property type="entry name" value="OS04G0405600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07082">
        <property type="entry name" value="DUF1350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49431" checksum="920C5D6D45E679CD" modified="2016-04-13" version="1">MAIVSFGTSTCGSMELAAYSFSPRHAQRDVVYLKSLSSQWQQQRPWWFGFSCDKIRNLDASGRSLRMISSGYAGRDTYRMKKDNDDKMYRRLDSCLVIPPPKGKKPKAIIKFLGGAFIGAVPEVTYSYLLGLLANEGYLIISVPYNVTFDHSQAASEVYERFHSCLKLILTSGLPNDDLLAAELVDLPLYSVGHSNGALLQVLTGSYFSEKIPKNMMFTFKALCFKIYGTVLESDVISPLLWKANAIISYNNRPATEAVPYFEQLGPLVSQLMPVVEASPVSSMAKGAADAWRVLLDTAEAMTPDYDPEARVSLNKFVDQLPSVFNQVAQGISEFRPTPIENREFCKNSYNVQKTLLVKFNVDAIDETDLLEETLRPRVEAIGGTLDKVSLSGNHITPCIQEPKLQAGDVYTPADAIAQGLKTLTLNETRILARTVADWFNNINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JST2</accession>
    <name>A0A118JST2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Concanavalin A-like lectin/glucanase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_026631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005388">
        <property type="protein sequence ID" value="KVH88525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JST2"/>
    <dbReference type="STRING" id="59895.A0A118JST2"/>
    <dbReference type="Gramene" id="KVH88525">
        <property type="protein sequence ID" value="KVH88525"/>
        <property type="gene ID" value="Ccrd_026631"/>
    </dbReference>
    <dbReference type="OMA" id="CYHMHCH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000318">
        <property type="entry name" value="C-type lectin receptor-like tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000393">
        <property type="entry name" value="C-type lectin receptor-like tyrosine-protein kinase At1g52310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052059">
        <property type="entry name" value="CR_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47973">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159635" evidence="6">
        <location>
            <begin position="34"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="68"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="284"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH88525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="570" mass="63831" checksum="83D3F5DBF5D37CF0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT22</accession>
    <name>A0A118JT22_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005149">
        <property type="protein sequence ID" value="KVH89742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT22"/>
    <dbReference type="STRING" id="59895.A0A118JT22"/>
    <dbReference type="Gramene" id="KVH89742">
        <property type="protein sequence ID" value="KVH89742"/>
        <property type="gene ID" value="Ccrd_008266"/>
    </dbReference>
    <dbReference type="OMA" id="THHETIP"/>
    <dbReference type="OrthoDB" id="4436220at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07821">
        <property type="entry name" value="PYR_PYL_RCAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF6">
        <property type="entry name" value="ABSCISIC ACID RECEPTOR PYR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24459" checksum="CC8AC94970BF92F0" modified="2016-04-13" version="1">MEKKSDTASMADDHRLSPPSPSEEKATGTFITPPGLTDAEFLVLKTAITEFHTYDLKSAQCSSLLAQHVDAPPDVVWSVIRQFDKPQIYKHFIKSCSVKEGSTMAEGCTRDVIVISGLPAATSTERLDLLDDERQVMAFTIIGGEHRLRNYRAVTTVHEIKVEGSPSTKTIVLESYMVDVPEGNTEEDTRFFADTVVKLNLQKLASVTEAIARGGAAAVESLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTC3</accession>
    <name>A0A118JTC3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_007417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTC3"/>
    <dbReference type="STRING" id="59895.A0A118JTC3"/>
    <dbReference type="Gramene" id="KVH90549">
        <property type="protein sequence ID" value="KVH90549"/>
        <property type="gene ID" value="Ccrd_007417"/>
    </dbReference>
    <dbReference type="OMA" id="AHERVYL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057372">
        <property type="entry name" value="Ubiquitin_UBP8/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF75">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25242">
        <property type="entry name" value="Ubiquitin_UBP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="334"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="860" mass="97119" checksum="4DA15C2906F3444D" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTR3</accession>
    <name>A0A118JTR3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTR3"/>
    <dbReference type="STRING" id="59895.A0A118JTR3"/>
    <dbReference type="Gramene" id="KVH90761">
        <property type="protein sequence ID" value="KVH90761"/>
        <property type="gene ID" value="Ccrd_007223"/>
    </dbReference>
    <dbReference type="OMA" id="WDQRNNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF91">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="366" mass="42745" checksum="0681334F6B348D63" modified="2016-04-13" version="1">MKSMYRSGFFKKSNDNGRIVISAIMGMIFGYFIGVSFPYFSFTKISSHSSIHSSFDVTMHEESKAHERSFPDNLGSSNTPELPKIYVPTNPHGAESLPPAIVVSETDFYLRRLWGEPSEDLKKKPRYLVTLTVGWDQRNNIDAAVKKFSDDFQIMLFHYDGRTTEWDQYEWSKQAIHISVRKQSKWYPEIPPWYAKRFLHPDIVAAYDFIFVWDEDLGVEHFNGDKYMQLVKKHRLEISQPGLEPNEGLTWEMTKRRGDREVHKFTDEKPGWCSDPHLPPCAAFVEIMAPVFSRDAWRCVWYMIQNDLVHGWGLDFALRRCVEGEYEKGKAPWEGVKERCKSEWALFQDRLVNADKAYLKQNGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTU7</accession>
    <name>A0A118JTU7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004927">
        <property type="protein sequence ID" value="KVH91552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTU7"/>
    <dbReference type="STRING" id="59895.A0A118JTU7"/>
    <dbReference type="Gramene" id="KVH91552">
        <property type="protein sequence ID" value="KVH91552"/>
        <property type="gene ID" value="Ccrd_006422"/>
    </dbReference>
    <dbReference type="OMA" id="IASWDMP"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20359" checksum="3CE02E68DBD33882" modified="2016-04-13" version="1">MSKKSSSKTSRPALQSPAIASWDMPKKSSAKTSRAAPQSAAIASWDMPKKSSSKKNSSKAPKPVPQSSAAAKAKSSSTPKTFGHEIEEIFSKKRKKTGHEKTRKVAEGVVGKPDKLDENMGKDSKKENSHKKRSRSGGSNVDVFENEQAARPKRKTADGLVIYSEEDLGIGRADAGGTRLCPFDCDCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTW8</accession>
    <name>A0A118JTW8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinonprotein alcohol dehydrogenase-like-superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_006289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004911">
        <property type="protein sequence ID" value="KVH91687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTW8"/>
    <dbReference type="STRING" id="59895.A0A118JTW8"/>
    <dbReference type="Gramene" id="KVH91687">
        <property type="protein sequence ID" value="KVH91687"/>
        <property type="gene ID" value="Ccrd_006289"/>
    </dbReference>
    <dbReference type="OMA" id="PCTALTW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45290">
        <property type="entry name" value="OS03G0300300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45290:SF1">
        <property type="entry name" value="OS03G0300300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="507"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH91687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="644" mass="70532" checksum="E9BA6AD7065BB679" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JTZ3</accession>
    <name>A0A118JTZ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_007282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JTZ3"/>
    <dbReference type="STRING" id="59895.A0A118JTZ3"/>
    <dbReference type="Gramene" id="KVH90654">
        <property type="protein sequence ID" value="KVH90654"/>
        <property type="gene ID" value="Ccrd_007282"/>
    </dbReference>
    <dbReference type="OMA" id="HRFKHIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH90654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="707" mass="76325" checksum="D7D71BA32D891D5C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUJ1</accession>
    <name>A0A118JUJ1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_006343</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004915">
        <property type="protein sequence ID" value="KVH91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUJ1"/>
    <dbReference type="STRING" id="59895.A0A118JUJ1"/>
    <dbReference type="Gramene" id="KVH91631">
        <property type="protein sequence ID" value="KVH91631"/>
        <property type="gene ID" value="Ccrd_006343"/>
    </dbReference>
    <dbReference type="OMA" id="GTISHYK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF338">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE, NON-RECEPTOR JAK_TYK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="371"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="736"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVH91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="790" mass="90081" checksum="F578581BBA2C098D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JW83</accession>
    <name>A0A118JW83_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_002898</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004432">
        <property type="protein sequence ID" value="KVH95034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JW83"/>
    <dbReference type="STRING" id="59895.A0A118JW83"/>
    <dbReference type="Gramene" id="KVH95034">
        <property type="protein sequence ID" value="KVH95034"/>
        <property type="gene ID" value="Ccrd_002898"/>
    </dbReference>
    <dbReference type="OMA" id="ECFRKFA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000003">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000007">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000058">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000645">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF5">
        <property type="entry name" value="OS04G0586500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0278">Fertilization</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="527"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="828"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH95034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="882" mass="95357" checksum="083884835B4EA1AC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY57</accession>
    <name>A0A118JY57_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIP1</name>
        <name evidence="12" type="ORF">Ccrd_001329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004268">
        <property type="protein sequence ID" value="KVH96580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY57"/>
    <dbReference type="STRING" id="59895.A0A118JY57"/>
    <dbReference type="Gramene" id="KVH96580">
        <property type="protein sequence ID" value="KVH96580"/>
        <property type="gene ID" value="Ccrd_001329"/>
    </dbReference>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000125">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03128">
        <property type="entry name" value="Lipoyl_synth_plantM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027527">
        <property type="entry name" value="Lipoyl_synth_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="121"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH96580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="372" mass="41432" checksum="A62C3DE14B729D29" modified="2016-04-13" version="1">MHSRFKSVSRTLINSNLLSSVSVRTFSSQFQQPQTLTELRHRLAADSPTLTDFIRLQSDEEYSVEVGTKKKPLPKPKWMKESIPGGEKYTHIKKKLRELKLHTVCEEAKCPNLGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPNEPSNVAEAIASWGLDYVVITSVDRDDLSDQGSGHFAETVQKLKILKPSMLIEALVPDFRGDVTCVEKVAKSGLDVFAHNIETVEELQSSVRDHRANFKQSLDVLMRAKDYAPAGTLTKTSVMLGCGETPDQVVNTMEKVRAAGVDVMTFGQYMRPSKRHMPVSEYITPEAFEKYRLLGMEMGFRYVASGPMVRSSYKAGEFYIKSMIERDRAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JYM8</accession>
    <name>A0A118JYM8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small-subunit processome, Utp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JYM8"/>
    <dbReference type="STRING" id="59895.A0A118JYM8"/>
    <dbReference type="Gramene" id="KVH98017">
        <property type="protein sequence ID" value="KVH98017"/>
        <property type="gene ID" value="Ccrd_023757"/>
    </dbReference>
    <dbReference type="OMA" id="WVKWCLI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45290:SF3">
        <property type="entry name" value="OS01G0649000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45290">
        <property type="entry name" value="OS03G0300300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="2">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="507" mass="54707" checksum="CD79C6440715C219" modified="2016-04-13" version="1">MAKERVKPLMSSFTSKAEVFAALLPNGVLKVWNTSDGNLLAEWKQPDGESDAHFSCIACSFVGKKRRKEKGTCLVALGTDDGEVFTINATAAEMKRIAALSFANKGRKLCVISTDGATCEMNSESGELLKETKISKKYISSAVYFSVRHISMLEDTNLIITSGFDDKNLQVWKNEANTEIVTSGPILSMRHPSLAIECKSGCNGEDLAVLSVSENGVAYIWNMKNSSEGNIVPAKIKVEAGESETDPNVSGKKKRHTSILAARLSSVDSDDRVTGVIVYGSINSPQFTSVDVTSPGEDIVIDARADVRENGVNDGKDHGDPMDGVQIDNDIDEPTMGEKLASLNITKNEGESEEKAESSPAKPPSADSVHVLLKQALHADDRNSVYLLNPSEVFKLLESLISMIQSRGAVIACALPWLKSLLLQHSSSIMSQESSLIALNSLYQTLDDGVDEGEGPLEPIIFEDVSDEDEDGSEEDGDNMETDEEDNEELEAVSNVSDLEGSDGMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ84</accession>
    <name>A0A118JZ84_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, TRAF-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_022088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003423">
        <property type="protein sequence ID" value="KVH99669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ84"/>
    <dbReference type="Gramene" id="KVH99669">
        <property type="protein sequence ID" value="KVH99669"/>
        <property type="gene ID" value="Ccrd_022088"/>
    </dbReference>
    <dbReference type="OMA" id="HYESTHA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051986">
        <property type="entry name" value="Innate_Immune_Apopt_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295:SF10">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295">
        <property type="entry name" value="TRAF-TYPE ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH99669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="217" mass="24627" checksum="92503FB23A715B5E" modified="2016-04-13" version="1">MTQNAELESFLSAGGKVFDIGGKQDRSIPQSSDRAIPSSNIDLHYAHCSRNLEKCKICDDMVPRKHAEEHYSSTHAPVSCSLCNEMMEREILAVHKGEKCPKRIVTCEYCEFPLPAIDLFEHQEVCGNRTELCHICNRYIRLRERVAHDVTCNGVPNNTAEIPRAMREDEREHPARRPPPPPPQDISTRRLIFTIAITGIAILIGYYISRENQTSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZJ5</accession>
    <name>A0A118JZJ5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003403">
        <property type="protein sequence ID" value="KVI00013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZJ5"/>
    <dbReference type="STRING" id="59895.A0A118JZJ5"/>
    <dbReference type="Gramene" id="KVI00013">
        <property type="protein sequence ID" value="KVI00013"/>
        <property type="gene ID" value="Ccrd_021758"/>
    </dbReference>
    <dbReference type="OMA" id="GYTTLCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF14">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="508"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="686" mass="76268" checksum="D919CD9B24256DCC" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0T4</accession>
    <name>A0A118K0T4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_020614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003130">
        <property type="protein sequence ID" value="KVI01126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0T4"/>
    <dbReference type="STRING" id="59895.A0A118K0T4"/>
    <dbReference type="Gramene" id="KVI01126">
        <property type="protein sequence ID" value="KVI01126"/>
        <property type="gene ID" value="Ccrd_020614"/>
    </dbReference>
    <dbReference type="OMA" id="MPSHQDK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI01126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39523" checksum="98894893A68C63F9" modified="2016-04-13" version="1">MKKEARLAPLFLSTLKSCPSLELKDARLQASCTSIESRGFEPRQGIRVMAEEVQMQEVEKGPRKRKIGHKKGKGKKKMKVNQGSGQKVKMDGKMKKLFRKKARDYNSDDSDDANDVNEEEPSPPMKFEEKQSHDENEEADEKSAEEEADVEEDMGNDDISDDEEGIIEHGIMKFSEGSTSFKKAFKKIIKRSGSDDVLGPVLSAYKKLVVKKLAEEADERKVKGDAKKEKTLERKDMSSLILSQSRTKNYSLELLQREVNKAQSSQKGLNPSRLKDAKVIQKRRKEAFFSELGKTPSGSNAMVASGGDGEGPAWAPLRDNYMLTTAKLKDWDKAADATDDFGRQEDSSSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K134</accession>
    <name>A0A118K134_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wound-responsive family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K134"/>
    <dbReference type="STRING" id="59895.A0A118K134"/>
    <dbReference type="Gramene" id="KVI02250">
        <property type="protein sequence ID" value="KVI02250"/>
        <property type="gene ID" value="Ccrd_019472"/>
    </dbReference>
    <dbReference type="OMA" id="MEIDCFG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022251">
        <property type="entry name" value="DUF3774_wound-induced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33090">
        <property type="entry name" value="DUF3774 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12609">
        <property type="entry name" value="DUF3774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11695" checksum="F35804A8B8F1EE20" modified="2016-04-13" version="1">MSGETVRKACVVAASIGAVEALKDQGVARWNRPLRELHHHAETNIVSSYWKITVDRPTRLPFTSTISSWLAVAMNGKHKVKRTKEESMKRVVETSCFGPNTVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K180</accession>
    <name>A0A118K180_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E2F Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K180"/>
    <dbReference type="STRING" id="59895.A0A118K180"/>
    <dbReference type="Gramene" id="KVI02433">
        <property type="protein sequence ID" value="KVI02433"/>
        <property type="gene ID" value="Ccrd_019191"/>
    </dbReference>
    <dbReference type="OMA" id="EDSQWKN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF99">
        <property type="entry name" value="E2F TRANSCRIPTION FACTOR-LIKE E2FF ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="180"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="398" mass="44884" checksum="E6425BA57822B5AA" modified="2016-04-13" version="1">MASLHDTETKNPSLYSRKEKSLGVLCSNFLRLYNRDGVESIGLDNAASQLGFRLKFMILETTGVERRRIYDIVNILESVGVRSLTLSAIHRCVVFEFPMNRCVLTRKAKNQYTWKGFNAIPYALEELRKQASNENSRGSQYCSFGTVLNENDCRGPSNSNNSNTDRHTKSSGSSKSENNRKEKSLGLLTQNFIKLFISSNVSKPVNKSVLLQHADLISLDTAATALLGDIHDPTAMRTKVRRLYDIANVFSSMNLLEKTKSQTLDTNNSKRRAFGTDITNHDDSKRHRIDSFSDWSSKEVSVAMHMNLDSVKVECDENLTMPPQCNSKEFVFGPFTPATAHKIGPSGNKKIKQAQDWENLADTYRPQYLLGDLFGHYAEAWKSWYAEAAEKKQVQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2G0</accession>
    <name>A0A118K2G0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002255">
        <property type="protein sequence ID" value="KVI04275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2G0"/>
    <dbReference type="STRING" id="59895.A0A118K2G0"/>
    <dbReference type="Gramene" id="KVI04275">
        <property type="protein sequence ID" value="KVI04275"/>
        <property type="gene ID" value="Ccrd_017408"/>
    </dbReference>
    <dbReference type="OMA" id="DIQFPEQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000020">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF529">
        <property type="entry name" value="HEAT-SHOCK PROTEIN DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="492" mass="54179" checksum="C83D18D4179DA34E" modified="2016-04-13" version="1">MGVDYYKILQVDKNAKDEDLKKAYRKLAMKWHPDKNPNNKKDAEAKFKQISEAYDVLSDPQKRAVYDQYGEEGLKGQMPPPDAAAGPGGATYFSTGGGTPFSFNPRNADDIFAEFFGFRGMGSGGDGGGVRGTRFSSNMFGDNMGGFDNIFSSFGSGGGGGAFGNGGGVGSGTRKDSPIERSLPCTLEELYKGTTKKMKISRDIADISGKTMTVEEILNINIKPGWKKGTKITFPEKGNEQPNMIPADLVFVIDEKPHTTFTRDGNDLVLTRRISLAEALAGCTVYLTTLDGRNLTIPVNNVIHPEYEEVVPREGMPNSKDPTKRGNLRIKFNIKFPSRLTATQKSKIKELLNVEEILNINIKPGWKKGTKITFPEKGNEQPNLIPADLVFDEKPHTTFIRDGNDLVLARQICLAEALTGCTVYLTTLDGRNLTILVINVIHPDYEEVVPREGRTNSKDPTKKGNLRIKFNINFPSRLTATQKSKIKELLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3I8</accession>
    <name>A0A118K3I8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TATA element modulatory factor 1 TATA binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_015689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001856">
        <property type="protein sequence ID" value="KVI05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3I8"/>
    <dbReference type="STRING" id="59895.A0A118K3I8"/>
    <dbReference type="Gramene" id="KVI05987">
        <property type="protein sequence ID" value="KVI05987"/>
        <property type="gene ID" value="Ccrd_015689"/>
    </dbReference>
    <dbReference type="OMA" id="EDCASHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47347">
        <property type="entry name" value="GOLGIN CANDIDATE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47347:SF2">
        <property type="entry name" value="GOLGIN CANDIDATE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="769"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122888" checksum="2C64244E44BED1A5" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K424</accession>
    <name>A0A118K424_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_014807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Plastid</location>
            <location evidence="8">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01001570">
        <property type="protein sequence ID" value="KVI06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K424"/>
    <dbReference type="STRING" id="59895.A0A118K424"/>
    <dbReference type="Gramene" id="KVI06838">
        <property type="protein sequence ID" value="KVI06838"/>
        <property type="gene ID" value="Ccrd_014807"/>
    </dbReference>
    <dbReference type="OMA" id="KFRGAYR"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0104">Cadmium</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10838" checksum="4D194A50EC0B38BA" modified="2016-04-13" version="1">MGAENMKVKLPHLIRAIRRVGQIVTWVSDPMHGNTIKAPLKAFFDVHEQEGSHLGGVHLEMTRQNVTECIGGSRIVAFDGLGSCYHSRCDPRLNVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K500</accession>
    <name>A0A118K500_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001139">
        <property type="protein sequence ID" value="KVI08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K500"/>
    <dbReference type="STRING" id="59895.A0A118K500"/>
    <dbReference type="Gramene" id="KVI08327">
        <property type="protein sequence ID" value="KVI08327"/>
        <property type="gene ID" value="Ccrd_013305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006476">
        <property type="entry name" value="CHP01589_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01589">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871:SF62">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871">
        <property type="entry name" value="OS02G0137100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09713">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="243" mass="27527" checksum="FAA67E5B839A160D" modified="2016-04-13" version="1">MSTGEYIKVCFEDLVKVESLIEQCLLHYMTQKQVIDILYQLQHIEPAFTETVWQKLEEQNQEFFQSYYLRVVVNEQIMEFNNLLGRQVALMNQVDPSVASFPPVSNVSHMPAMKTENMQPSVPTVLVNGFNNCGPFIHSGMQHALDRSTYSRRIDVPSNMVLAHNSDIRMMEGIVIKSEPGYLDNSRYMISSNIGEVASILLTAAIGISEGRRHDSCSASMDESCYRWTSCNNLGLIQQTNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5C4</accession>
    <name>A0A118K5C4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_012737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the plant CAR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001080">
        <property type="protein sequence ID" value="KVI08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5C4"/>
    <dbReference type="STRING" id="59895.A0A118K5C4"/>
    <dbReference type="Gramene" id="KVI08898">
        <property type="protein sequence ID" value="KVI08898"/>
        <property type="gene ID" value="Ccrd_012737"/>
    </dbReference>
    <dbReference type="OMA" id="RTNCIAE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044562">
        <property type="entry name" value="CAR1-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933:SF28">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933">
        <property type="entry name" value="PROTEIN C2-DOMAIN ABA-RELATED 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="199"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="380" mass="43627" checksum="B41DC09EAA038C40" modified="2016-04-13" version="1">MSMDDLVGLLRVHVHRGVNLAIRDLRSSDPYVIIRMGRQKLRTRVVKRNINPVWDEDLTLSILEPLPVKLVSCSPISSLYNHHHLNFKIQILVVTFLHLELDLNNSQEQEVYDRDIFSTDDKMGDAEFDFKPFMEAVKMRLNDDLPNNTIITTVKPTRTNCLAEESHITWTDNRVIQNMVLRLRNVESDPLFCLLSTFPPYLPSILILVFNSITKMERLVGLLSIHVRKGVNLASRDIRGSDPYVIFRLDQYKLKTAVVNNNINPVWDEFLTLPVFEPLPIKMEVYDKDVFSHDDKMGDAEFDIKPFLEALKLRLDDLPSETIIATVKPTRTNCIAEESHITWTNGKLVQTMVLRLRNVVSGEIEIQLGWVDVPGSKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5T8</accession>
    <name>A0A118K5T8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001051">
        <property type="protein sequence ID" value="KVI09643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5T8"/>
    <dbReference type="STRING" id="59895.A0A118K5T8"/>
    <dbReference type="Gramene" id="KVI09643">
        <property type="protein sequence ID" value="KVI09643"/>
        <property type="gene ID" value="Ccrd_012015"/>
    </dbReference>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="253" mass="28324" checksum="6AAA0C523476C957" modified="2016-04-13" version="1">MRRVFGVKKDKEPPPSINDASDRINKRGETVDEKIKRLDGELARYKEQIKKTRPGPAQEAVKARAMRVLKQKRMYEGQRDMLYNQTFNLDQVAFASEGIKDAQQTVRFATINYLLLLMTALKSANKELKGMMKTVKIQDIDSLQDEMMDMMDISNEIQESLGRSYSVPDDIDEDDLMGELDALEADMGLETEGEGVPSYLQPDNEPEELNLPSAPSGHAGRVNNEVPSKYLSSVGYAVDELGLPAVPHASLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6H7</accession>
    <name>A0A118K6H7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001004">
        <property type="protein sequence ID" value="KVI10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6H7"/>
    <dbReference type="Gramene" id="KVI10667">
        <property type="protein sequence ID" value="KVI10667"/>
        <property type="gene ID" value="Ccrd_010926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="82" mass="9725" checksum="F99E5546BA020AAE" modified="2016-04-13" version="1">MAERRRICRSAEQQWWNFRTESKSETLESQAIDLETDVEDHVDVIAIKETGVLRLTVHTTVWSLEFVNHVANQWKKIEEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6V4</accession>
    <name>A0A118K6V4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ccrd_010339</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="LEKV01000589">
        <property type="protein sequence ID" value="KVI11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K6V4"/>
    <dbReference type="Gramene" id="KVI11253">
        <property type="protein sequence ID" value="KVI11253"/>
        <property type="gene ID" value="Ccrd_010339"/>
    </dbReference>
    <dbReference type="OMA" id="EAIHTWK"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007160018" description="E3 ubiquitin-protein ligase listerin" evidence="17">
        <location>
            <begin position="19"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1853"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KVI11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1903" mass="213366" checksum="4C71B0276159AF77" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K776</accession>
    <name>A0A118K776_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_009783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000040">
        <property type="protein sequence ID" value="KVI11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K776"/>
    <dbReference type="STRING" id="59895.A0A118K776"/>
    <dbReference type="Gramene" id="KVI11803">
        <property type="protein sequence ID" value="KVI11803"/>
        <property type="gene ID" value="Ccrd_009783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="16098" checksum="F6C74A7F74DAA212" modified="2016-04-13" version="1">MVVFGDCLRVIFVLEIIKHFMFCLLFYFGNSRSPLLLETSHSQSEKMKITGKTDLPAIISSKVLNFTPDSDLLQKPISRKQVSRKSRNSGGGVRLRRDGVPAGGKRGSRPETPLLRWKFDEGKGKEEKDVEVKNCNVNQLICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7J4</accession>
    <name>A0A118K7J4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunoglobulin E-set</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000006">
        <property type="protein sequence ID" value="KVI12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7J4"/>
    <dbReference type="STRING" id="59895.A0A118K7J4"/>
    <dbReference type="Gramene" id="KVI12345">
        <property type="protein sequence ID" value="KVI12345"/>
        <property type="gene ID" value="Ccrd_009229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF49">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="124" mass="14087" checksum="B6FA18D0670FDDD7" modified="2016-04-13" version="1">MSNNVEEITTSLPVEESKRGHLLFTLKEGVHYRLKLSFTVLHNIVSGLTCINTVWKGGIQVDRIKGMLGTFAPQKDAYVETLDEETTPSGVLARGIYKAKLKFEDDDKRCYLELDYSFEIKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAZ6</accession>
    <name>A0A124SAZ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-/Glucose-6-phosphate 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005316">
        <property type="protein sequence ID" value="KVH89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAZ6"/>
    <dbReference type="STRING" id="59895.A0A124SAZ6"/>
    <dbReference type="Gramene" id="KVH89047">
        <property type="protein sequence ID" value="KVH89047"/>
        <property type="gene ID" value="Ccrd_008969"/>
    </dbReference>
    <dbReference type="OMA" id="ARNKVWV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF10">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="233" mass="25937" checksum="5B3D6D37B788BEF5" modified="2016-04-13" version="1">MGHSAAVWDSRMALEKTKDWNGIDQIVLRNPQGASAKAIFKPPKAMRGGIPICFPQFGNCGSLEQHGFARNKIWVVEDDPPPLPANDSHGKSFVDLLLKPSEEDLKFWPHSFEFRLRVSLGMDGNLTLTSRIRNVNGKPFSFSFAYHSYLSVSDISSPNCVAVLDHERKRTYVLRKEGLPDVAMADLGDDEYKQMLCVDGAAIEKPITLKPGEEWTGRLEIAVVPSSFCSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB98</accession>
    <name>A0A124SB98_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_008030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005120">
        <property type="protein sequence ID" value="KVH89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SB98"/>
    <dbReference type="Gramene" id="KVH89980">
        <property type="protein sequence ID" value="KVH89980"/>
        <property type="gene ID" value="Ccrd_008030"/>
    </dbReference>
    <dbReference type="OMA" id="ILIRHQW"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14353">
        <property type="entry name" value="UBA_FAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="458" mass="50176" checksum="197981159D9F65ED" modified="2016-04-13" version="1">MSGSADKLAHFQAITGLQDADLCTEILSAHGWDLQQAISSITSTSDSDHATSATDNIAADRFEQSGFVAAEGAGPPGLAWKLISLPVSIVSGSLGLVSGAVGLGLWAVGGVLSYSLSMIGLTNSGRNDGSPSTPLVSLSTAASEAMDFVSKFEGEYGDRHPDFVXEGFMDALQRSRHEFKLLFVYLHSPDHPDTPSFCEDTLCSEVLSAFVNENFVVWGGNIRASEGFKMSNSLKASRFPFCAVVMAATNQRIALLQQVEGPKSPEEMLTVLQRVLEESAPVLVTARLDAEERRNNIRLREEQDAAYQAALEADQARERQRREEQERLEREAAEAERKQKEEEEARERAAREAAEREAALIKLREEKSLSLGPEPEKGPDVTQVLVRLPNGERKGRRFHCSATIQSLYDFVDSSGILEMGSYTLVTNFPRVLYGPEKLCLTLKEVGLHPQASLFVEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBG9</accession>
    <name>A0A124SBG9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, GATA-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_007363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005098">
        <property type="protein sequence ID" value="KVH90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBG9"/>
    <dbReference type="Gramene" id="KVH90622">
        <property type="protein sequence ID" value="KVH90622"/>
        <property type="gene ID" value="Ccrd_007363"/>
    </dbReference>
    <dbReference type="OMA" id="MPRRCTH"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF143">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24350" checksum="54789B3FB37869A1" modified="2016-04-13" version="1">MDFCQNISAAGGLPTTYQPPEQHLLCSLDDLLSGHSMEDVNMEWLSIFVEDCLSSSGNCMPPAEVKPQSTTFNAQGTNTSAEPPMKETHSMLKLVVPSKARSKRKRSQTCWSQQYLVGKKCTTPNSTNSGQEEGSSGQGQGQGRKCTHCLSQRTPQWRAGPQGPKTLCNACGVRYKSGRLLPEYRPAKSPTFVSHKHSNSHKKVLEMRMTILPSSLANSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCH3</accession>
    <name>A0A124SCH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_004131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004598">
        <property type="protein sequence ID" value="KVH93807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCH3"/>
    <dbReference type="STRING" id="59895.A0A124SCH3"/>
    <dbReference type="Gramene" id="KVH93807">
        <property type="protein sequence ID" value="KVH93807"/>
        <property type="gene ID" value="Ccrd_004131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46234">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH93807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="276" mass="30487" checksum="E8E6D4D3FE56A87B" modified="2016-04-13" version="1">MKSKCGISSHCFFSVAALTGCISVIVNMSLTDPPLESGGITASREFKFGPTFVVKPKGKHQATIVWLHGLGDDGSSWSQLLETLPLPNIKWICPTSPVQPLTLFDGLSTTTWFDIIDKSEDASQDEALVWVQQLRYTLQVALLVENWEMALVTLPILTWLLVLAAGFRVQSSSFHRHCFSILVILLTYAKLDLSNKVGGYKVEGHAASLPILLCHGRGDDVVHFRYGKKSAEKLTSAGFRNLTLKSFHSLGHYIIPEEIDEVSSWLISNLELEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD95</accession>
    <name>A0A124SD95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec-independent periplasmic protein translocase, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_001676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004344">
        <property type="protein sequence ID" value="KVH96236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD95"/>
    <dbReference type="STRING" id="59895.A0A124SD95"/>
    <dbReference type="Gramene" id="KVH96236">
        <property type="protein sequence ID" value="KVH96236"/>
        <property type="gene ID" value="Ccrd_001676"/>
    </dbReference>
    <dbReference type="OrthoDB" id="36838at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009977">
        <property type="term" value="F:proton motive force dependent protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371:SF0">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH96236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="350" mass="38315" checksum="BBFC542EA9BABCCF" modified="2016-04-13" version="1">MGSTNALIYNLHLNTNNCFNCVNSRTNHSTSLHINHRKSPLNVSSKRQRKINKFVCSAIEDVREMQKRLGIGGAGSVLDDRPEVADDIDENAPANSGPNDGSALYNFLYPDKELLPEDKEMSIFDHLEELRERIFVSVLAVGAAILGCFAYSKDLIMILEAPVRTQGVRFLQLAPGEFFFTTIKVSGYCGLLLGSPVILYEIIAFVLPGLTRSERRFLGPIVLGSSVLFYAGIAFSYVVLTPAALNFFVNYAEGVVESLWSIDQYFEFILVLMFSTGLSFQVPVIQLLLGQVGLVSGNQMLSVWRYVVVGSVAAAAVVTPSTDPLTQMLLAGPLLGLYFGGAWTVKLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDE5</accession>
    <name>A0A124SDE5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004251">
        <property type="protein sequence ID" value="KVH96700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDE5"/>
    <dbReference type="STRING" id="59895.A0A124SDE5"/>
    <dbReference type="Gramene" id="KVH96700">
        <property type="protein sequence ID" value="KVH96700"/>
        <property type="gene ID" value="Ccrd_001211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF91">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="43052" checksum="73D2A86F0C823D91" modified="2016-04-13" version="1">MAEQTLGIMSSVGGGFGNGGIWGMRPFDSQNGDTVRRRNSPNSSGSSEASGQAGGWFPVKQAATAATLALTGDTIAQLRERWVKSKTLYNQQPSDSHEIVAFGKLHELCCALICPFGCTIVIIGTNTFRSLRANTELLAVVSFGTMHGDDSCQGERSVVGGGVDNSERALVRREEIENDEKKNRGDREETLGSGLALSERRYWKDETWTLLDHNWLRALRMTSYGFLLYGPGSYVWYQYLDRCMPKQTAQNVLIKVVLNQIVLGPSVIAVVFAWNNLWQGKLSELPNKYKKDALRTLLFGFRFWIPVSVVNFWAIPLQARVGFMSMNSIFWNFYLSSTLNNHIDMQHSIDTGYDMSNNSRHYVTNGDRPHPSTLNERVDVDPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SDE8</accession>
    <name>A0A124SDE8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004252">
        <property type="protein sequence ID" value="KVH96697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SDE8"/>
    <dbReference type="Gramene" id="KVH96697">
        <property type="protein sequence ID" value="KVH96697"/>
        <property type="gene ID" value="Ccrd_001221"/>
    </dbReference>
    <dbReference type="OMA" id="PAFTIVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="692" mass="77836" checksum="44C55CDF8D09A503" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SE08</accession>
    <name>A0A124SE08_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC/ECF transporter, transmembrane component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003788">
        <property type="protein sequence ID" value="KVH98577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SE08"/>
    <dbReference type="STRING" id="59895.A0A124SE08"/>
    <dbReference type="Gramene" id="KVH98577">
        <property type="protein sequence ID" value="KVH98577"/>
        <property type="gene ID" value="Ccrd_023199"/>
    </dbReference>
    <dbReference type="OMA" id="MTRAINW"/>
    <dbReference type="OrthoDB" id="2019294at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16914">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33514">
        <property type="entry name" value="PROTEIN ABCI12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33514:SF13">
        <property type="entry name" value="PROTEIN ABCI12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43347" checksum="77DBC3FB4A4BAF64" modified="2016-04-13" version="1">MYNPLPQIHPTANFTPHSLSSHNPHIFFIHQFHQNLKIPKYSYSSLPYNRKTLFKTRIKCTENSDSNPAKWERLLPKNIISADKILRSIAGATSSPICQFISSPTTFLHTVDPRIKLAWLLVLVVLPARSHIYMRFGLITFLALLSVWIQPRQVWVDQLGRVALLSGILFLMLGLGADSMPMVVQSRTPPPSMMGLSAIPSSFAGYSYLLFKLGPLQLTRKGLSVASTSACLTFTIFQSASLCLSTTTPEQLAFGLEWFMKPLAYVGVPVAEVILTLLLSLRFINLVFDEVRIVALGIVSRRINWQQLATMETVEVFFTYIRRIFKNIFNHAEQITQAMNVRGFRGDSKLHKIYFSSTSSAAVANVISIMTLVGLISAAVLSEYMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFW9</accession>
    <name>A0A124SFW9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_017108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARR-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001979">
        <property type="protein sequence ID" value="KVI04576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFW9"/>
    <dbReference type="STRING" id="59895.A0A124SFW9"/>
    <dbReference type="Gramene" id="KVI04576">
        <property type="protein sequence ID" value="KVI04576"/>
        <property type="gene ID" value="Ccrd_017108"/>
    </dbReference>
    <dbReference type="OMA" id="CKDAYTT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009640">
        <property type="term" value="P:photomorphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010218">
        <property type="term" value="P:response to far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010114">
        <property type="term" value="P:response to red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd17582">
        <property type="entry name" value="psREC_PRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF95">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR-LIKE APRR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="58"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="12">
        <location>
            <begin position="550"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="606" mass="66874" checksum="741C7F02E1E03A17" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG09</accession>
    <name>A0A124SG09_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_016745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001899">
        <property type="protein sequence ID" value="KVI04923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG09"/>
    <dbReference type="STRING" id="59895.A0A124SG09"/>
    <dbReference type="Gramene" id="KVI04923">
        <property type="protein sequence ID" value="KVI04923"/>
        <property type="gene ID" value="Ccrd_016745"/>
    </dbReference>
    <dbReference type="OMA" id="IEQTINW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000465">
        <property type="entry name" value="Heat shock cognate 70 kDa protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000005">
        <property type="entry name" value="heat shock cognate 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000542">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="570" mass="62072" checksum="E9DB7BCA68EFF8C2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG21</accession>
    <name>A0A124SG21_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_016658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001891">
        <property type="protein sequence ID" value="KVI05011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG21"/>
    <dbReference type="STRING" id="59895.A0A124SG21"/>
    <dbReference type="Gramene" id="KVI05011">
        <property type="protein sequence ID" value="KVI05011"/>
        <property type="gene ID" value="Ccrd_016658"/>
    </dbReference>
    <dbReference type="OMA" id="MGTTKMV"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000004">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017131">
        <property type="entry name" value="snRNP-assoc_SmB/SmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037187">
        <property type="entry name" value="snRNP_SmB/SmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI05011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="277" mass="29422" checksum="8A4B99B8B983878F" modified="2016-04-13" version="1">MSMSKGSKMLQFINYRMRITIQDGRQLVGKFMAFDRHMNLVIGDCEEFRKLPPAKGAKKNEEREDRRTLGLVLLRGEEVISMTVEGPPPPDENRAKAVGAAALAGPGLGRAAGRGIPTAPMIQAQPGLAGPVRGIGGPAPGMMQPQISRPPVPNMSAPPMNYPQAPVIRPGQMPYPGQGPPPQMPRGPPPQMPPQFAQRPPGQYQVPPPGQYGQRPMVPPPQMMRGPPPPGGPPRPGMPGPPPPARPGMPPPGGQIPGFGPPRPGMPPPPSTQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGD8</accession>
    <name>A0A124SGD8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_015563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001851">
        <property type="protein sequence ID" value="KVI06091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGD8"/>
    <dbReference type="STRING" id="59895.A0A124SGD8"/>
    <dbReference type="Gramene" id="KVI06091">
        <property type="protein sequence ID" value="KVI06091"/>
        <property type="gene ID" value="Ccrd_015563"/>
    </dbReference>
    <dbReference type="OMA" id="YWSEEDY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF56">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI06091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="443" mass="49725" checksum="4CE99BC83F0BF88B" modified="2016-04-13" version="1">MELLLTEENGKKRSLITDENSERKRRKQEHSNYGDGMAWFRGSLIGKGCFGSVFLANLKKPKSRYSSYPPIMAVKSAEVSVSSSIQKEREVLNNIRGCRNVIRCFGEEITTGENGQMVYNLLLEYGSGGTLADLIKKSDGNGLPEFDARRHTRSILRGLRHIHHCGYVHCDLKPENILLVASSVDGGFTAKIGDLGLAKRAKQSKKSKSVSYWRGTPMYFSPEVVIDGVQEPPSDIWTIGCVLLEMLTGKPPWDSKPETNGDEILSRIGENNESPSIPTTISREARSFLKGCFSRKAMYRWTAEMLLAHPFLEGIGDDEDDDHKVEEPEVLDINAISSSMMSESEDDDEISFSSFSDGSEEELYFWSEEDADGMENEISSCFSVEESLKADRSTTAPLNEINYGFRSSLLRVFFKHLWQNTYLDSCLSETLNTLHLRSSLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGQ6</accession>
    <name>A0A124SGQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001519">
        <property type="protein sequence ID" value="KVI07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGQ6"/>
    <dbReference type="STRING" id="59895.A0A124SGQ6"/>
    <dbReference type="Gramene" id="KVI07127">
        <property type="protein sequence ID" value="KVI07127"/>
        <property type="gene ID" value="Ccrd_014513"/>
    </dbReference>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="OrthoDB" id="189057at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030899">
        <property type="term" value="F:calcium-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010020">
        <property type="term" value="P:chloroplast fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051782">
        <property type="term" value="P:negative regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02036">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000068">
        <property type="entry name" value="Site-determining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050625">
        <property type="entry name" value="ParA/MinD_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43384:SF6">
        <property type="entry name" value="SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43384">
        <property type="entry name" value="SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="4">
        <location>
            <begin position="62"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="327" mass="35817" checksum="E7DC50D1B055A60E" modified="2016-04-13" version="1">MTSLRWLTEPSSLCSPNFLPFKPMYKTLPRPTTKPYPKSSPIRSVLQYNRKPELAGGTPRVVVITSGKGGVGKTTTTANVGLSLARLGFSVVAIDADVGLRNLDLLLGLENRVNYTVVEVLNGDCRLDQALVRDKRWSNFELLCISKPRSKLPLGFGGKALVWLVDALKDRQEGCPDFILIDCPAGIDAGFITAITPANEAVLVTTPDITALRDADRVTGLLECDGIRDIKMIVNRVRTDLIRGEDMMSVLDVQEMLGLALLGVIPEDSEVIRSTNRGFPLVLNKPPTLAGLAFEQAAWRLVEQDSMKAVMVEEEPKKRGFFSFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGS5</accession>
    <name>A0A124SGS5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001508">
        <property type="protein sequence ID" value="KVI07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGS5"/>
    <dbReference type="Gramene" id="KVI07306">
        <property type="protein sequence ID" value="KVI07306"/>
        <property type="gene ID" value="Ccrd_014348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176242" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7738" checksum="B66BD1A526460A2B" modified="2016-04-13" version="1">MDRKLVGLLCFIVLILNFLVIGAEKSTTITSQVHVALRSRKILHYPRYGPGRDFGLSSVPPPDFILYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGV7</accession>
    <name>A0A124SGV7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001503">
        <property type="protein sequence ID" value="KVI07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGV7"/>
    <dbReference type="STRING" id="59895.A0A124SGV7"/>
    <dbReference type="Gramene" id="KVI07578">
        <property type="protein sequence ID" value="KVI07578"/>
        <property type="gene ID" value="Ccrd_014105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000250">
        <property type="entry name" value="RNA-binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="194" mass="21070" checksum="710D94BF5C564B7B" modified="2016-04-13" version="1">MAYQQSIPATPSSGPSSTSGFQSPFGDTTFTKVFVGGLAWETQSETMRHYFEQFGEILEAVVITDKNTGRSKGYGFVTFRDPESATKSCVDPAPVIDGRRANCNLASLGRPRAPPPFGGITSPIPYAGGLQTARGVYNLYSGQQYLQMMYPYNQISQFGHGYTAFQGYGLPTSSSIQTIQAAYPIGSVFFQKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHJ7</accession>
    <name>A0A124SHJ7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_011879</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI09751">
        <property type="protein sequence ID" value="KVI09751"/>
        <property type="gene ID" value="Ccrd_011879"/>
    </dbReference>
    <dbReference type="OMA" id="WVANSEI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000005">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF235">
        <property type="entry name" value="OS01G0783900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="14">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="15">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="515"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="14">
        <location>
            <begin position="869"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117312" checksum="49B83D40DF9F429A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHL6</accession>
    <name>A0A124SHL6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">50S ribosomal protein L11, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">CL11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011679</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001036">
        <property type="protein sequence ID" value="KVI09931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHL6"/>
    <dbReference type="STRING" id="59895.A0A124SHL6"/>
    <dbReference type="Gramene" id="KVI09931">
        <property type="protein sequence ID" value="KVI09931"/>
        <property type="gene ID" value="Ccrd_011679"/>
    </dbReference>
    <dbReference type="OMA" id="CKNIDSA"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000001">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="12">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="11">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="226" mass="23829" checksum="4F96179AD68CFBC7" modified="2016-04-13" version="1">MASSLSTYHPISSHLSKQNHTSNLSSSFLSSPSSIPLSSNSNVSLQFRCNNKQLCSSTPRPLTVIAMAPPKPGGKAKKVTGIIKLALEAGKATPAPPVGPALGSKGVNIMAFCKDYNARTADKAGYIIPVEITVYDDKSFTFVLKTPPASVLLLKAAGVDKGSKDPQREKVGKVTIDQLRGIATEKMPDLNCTTIESAMRIIAGTAANMGIDVDPPILTPKVKQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5B8</accession>
    <name>A0A103D5B8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01012818">
        <property type="protein sequence ID" value="KVD98096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5B8"/>
    <dbReference type="Gramene" id="KVD98096">
        <property type="protein sequence ID" value="KVD98096"/>
        <property type="gene ID" value="Ccrd_024313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVD98096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="76" mass="8883" checksum="EB20E04C18A8AD5D" modified="2016-04-13" version="1">MSTIKNFGIEISVKNKDKQKTILEQRIPIEIKKGPWKVEEDELLIKHVEEYGPEIGIFLFQKNIFNAWENHVVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103NAB3</accession>
    <name>A0A103NAB3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_026565</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01008645">
        <property type="protein sequence ID" value="KVG09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103NAB3"/>
    <dbReference type="STRING" id="59895.A0A103NAB3"/>
    <dbReference type="Gramene" id="KVG09400">
        <property type="protein sequence ID" value="KVG09400"/>
        <property type="gene ID" value="Ccrd_026565"/>
    </dbReference>
    <dbReference type="OMA" id="GQEYHYR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF431">
        <property type="entry name" value="LACCASE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0052">Apoplast</keyword>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="300"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVG09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="449" mass="49329" checksum="9411363EFBFCFA73" modified="2016-04-13" version="1" fragment="single">MNIKSHCDVGQEGTLWWHAHSSWLRATVYGAIIIHPKEGSSYPFPKPKRDSVIALGEWWDANPIDVIREATRTGATPNVSDAYTINGQPGDLYNCSSKGETNLIRVINAALNQQLFFTIANHKLTVVGADASYVKPFTTSVLMLGPGQTTDVLVKADQPPARYYIAARAYASAQGAPFDNTTTTAILEYKTAPCTAKCTTSKPIMPRLPAYNDTTTATAFTTSFRSPRKVFVPTEIDENLFITAGLGINQCPPKTRARNCQGPNGTRFTASMNNVSFVLPSNFSLLQAHHQGVRGVFTTDFPAKPPVKFDYTGNVSRSLWQPTPGTKVYRLKYGSRVQIVLQGTNIFTAENHPIHLHGYDFYILAEGFGNFNPKTDSAKFNLVDPPLRNTVSLPVKGWAVIRFVADNPGVWIMHCHLDVHIGWGLATVFLVDNGVGPLQQLEQPPPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103NTU9</accession>
    <name>A0A103NTU9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008497">
        <property type="protein sequence ID" value="KVG18461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103NTU9"/>
    <dbReference type="Gramene" id="KVG18461">
        <property type="protein sequence ID" value="KVG18461"/>
        <property type="gene ID" value="Ccrd_026539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG18461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="177" mass="19499" checksum="4A8772A7F6E761AF" modified="2016-04-13" version="1" fragment="single">MTTKESPPPAASAPVMTSCRRKKSEDATFLQDEKLAMSAAGGLCTSSGPVIGERNLTIFDVLDILHKDFIMLLHLLCSLATNSPGNIMPTIRGTEGRGKWGHARWPIKIANEKNFKGFVSLSTTKAGVEETCIIVSYFPIIKFSYAAYFELINASNFFMLLMMADGMKEKDKSHDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103S0Y9</accession>
    <name>A0A103S0Y9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007650">
        <property type="protein sequence ID" value="KVG77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103S0Y9"/>
    <dbReference type="Gramene" id="KVG77635">
        <property type="protein sequence ID" value="KVG77635"/>
        <property type="gene ID" value="Ccrd_026200"/>
    </dbReference>
    <dbReference type="OMA" id="DMDYPSE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF337">
        <property type="entry name" value="OS04G0109900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="7">
        <location>
            <begin position="128"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG77635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="49486" checksum="06D81B67009B076B" modified="2016-04-13" version="1" fragment="single">MKTTRQGGVSAYVTTAPAIALTTVVIILILSFNFFTRNNSKPEFVIPIVQLQSKLNLSRQPSDDYKFRAVITPDLHRISSLPLQLNRNRTFITGRRRLELELARARATIREAASVRNLSQLLQSGDVLSKGELPIVHDGPCKDIYTVEGRFIQEMEQGRRGHYFRTKDADRAHVYFMPFSVTWMVKYLYKPDTYDVTPLRHFVSDYVRVISTKHPFWNKTHAADHFMLSCHDWGPHASKGHPNLYNTSIRVLCNANSSEGFNPQKDVSLPEINLRTGNIPPNLLSPPSSTTPRIHLAFFAGGVHGPIRPLLLHHWRGRDPDLQVYEYLPKNLDYYSFMFASKYCLCPSGYEVASPRIVESIYSECVPVIISENYVLPFSDVLKWEAFSIRVKVSEIGRLKEILTSVPEEKYLRLKSNLRAVRRHFVLNQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SVK2</accession>
    <name>A0A103SVK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007324">
        <property type="protein sequence ID" value="KVG96848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103SVK2"/>
    <dbReference type="Gramene" id="KVG96848">
        <property type="protein sequence ID" value="KVG96848"/>
        <property type="gene ID" value="Ccrd_026062"/>
    </dbReference>
    <dbReference type="OMA" id="REIAYAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVG96848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23322" checksum="4C7C351BDF80E15A" modified="2016-04-13" version="1">MEVASLLHDDVLDDADTRRGIGSLNFVMGNKLAVLAGDFLLSRACITLASLKNTEKTYYKTXSLISNSCKSIALLTGQTAEVSMLAYEYGKNLGLAFQLIDDVLDFTGTSSSLGKGALSDIRHGIVTAPILYAMEEFLELRSVVDQGLDDPANVDLALEYLGKSHGIQRTRELAAKHASLASAAIDXLPENDDEDVQRSRXALVELTXRVINRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103TF61</accession>
    <name>A0A103TF61_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007117">
        <property type="protein sequence ID" value="KVH16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103TF61"/>
    <dbReference type="STRING" id="59895.A0A103TF61"/>
    <dbReference type="Gramene" id="KVH16096">
        <property type="protein sequence ID" value="KVH16096"/>
        <property type="gene ID" value="Ccrd_025922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051708">
        <property type="entry name" value="Plant_Aspart_Prot_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967:SF67">
        <property type="entry name" value="ASPARTYL PROTEASE AED3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967">
        <property type="entry name" value="OS07G0603500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007117875" evidence="4">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="271" mass="29255" checksum="E4DAB77EF376D307" modified="2016-04-13" version="1">MEPLHVTLLFLLSLTLVNSLSPNCDSPSQGSTLRVYHVSSPCSPFRPKTTLSWEESVLQMQADDKTRLVYLTSLVAGRSFVPIGSGRQIIQSPTYIVKANIGTPAQSLLMALDTSTDMALVPCAGCVGCSSVTYDSAKSTSFSSLACGAEQCKQVRTVFTRLVDGAYTAVRDEFRRRMGKTAVVSSLGGFDTCYTIPIGKQVPTMTFMFPGLNMSLPQDNFLIHSSSGATTCLAMSSSPALNVIANMQQQNHRIVFDIPNSRLGISREICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XB17</accession>
    <name>A0A103XB17_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2A, regulatory subunit PR55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006243">
        <property type="protein sequence ID" value="KVH87423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XB17"/>
    <dbReference type="STRING" id="59895.A0A103XB17"/>
    <dbReference type="Gramene" id="KVH87423">
        <property type="protein sequence ID" value="KVH87423"/>
        <property type="gene ID" value="Ccrd_025339"/>
    </dbReference>
    <dbReference type="OMA" id="YANGGCI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="136" mass="15291" checksum="9EB386A6DE32DC06" modified="2016-04-13" version="1" fragment="single">MVSGIEFAKTGKHLATRDRGGRVVLFDRVDFDYLKSLEIEVKINMIRWCQTANSAIFLLSTNDKTIKFWKSKKRRSSNFNVEPSRPMSDGFISSLNVPTSFKACYANGGCIDNCLSCRSNNLSFLPGGITSLRLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDF8</accession>
    <name>A0A103XDF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_026103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005350">
        <property type="protein sequence ID" value="KVH88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDF8"/>
    <dbReference type="STRING" id="59895.A0A103XDF8"/>
    <dbReference type="Gramene" id="KVH88685">
        <property type="protein sequence ID" value="KVH88685"/>
        <property type="gene ID" value="Ccrd_026103"/>
    </dbReference>
    <dbReference type="OMA" id="REYKDDH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000318">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="248"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="707" mass="83613" checksum="A71F2ADA638A3EA7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDT0</accession>
    <name>A0A103XDT0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005333">
        <property type="protein sequence ID" value="KVH88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDT0"/>
    <dbReference type="Gramene" id="KVH88821">
        <property type="protein sequence ID" value="KVH88821"/>
        <property type="gene ID" value="Ccrd_025397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="109" mass="12895" checksum="6CF19F2F5FE7C329" modified="2016-04-13" version="1">MSVLPYVRAPYLHVAMLLFSCVLYLCFCFAKWGLHKNKLCKGKGEVRLPLLSTLILSLCAIYWVRVQEITFHQRQRRVLNQTLHIDTHRNNIQSIVLIGGIHFLFRWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEK3</accession>
    <name>A0A103XEK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High mobility group (HMG) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005261">
        <property type="protein sequence ID" value="KVH89300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEK3"/>
    <dbReference type="STRING" id="59895.A0A103XEK3"/>
    <dbReference type="Gramene" id="KVH89300">
        <property type="protein sequence ID" value="KVH89300"/>
        <property type="gene ID" value="Ccrd_008713"/>
    </dbReference>
    <dbReference type="OMA" id="KFDAMKP"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22005">
        <property type="entry name" value="HMG-box_AtHMGB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF12">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="146" mass="16786" checksum="03C065DBF6A59C03" modified="2016-04-13" version="1">MAKTASASTPAETPAKTAHEKMALRPRSKLTMKQSSTAKRPKMAAAKKKASKLDANKPKKPPTAFFYFLEDFRKEFQEQNPDVKSMREIGKACGEKWKIMTYEEKVEYYDVATVKRAEFEKAMADYINKKESGEYDEFDEDSDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFH1</accession>
    <name>A0A103XFH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005163">
        <property type="protein sequence ID" value="KVH89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFH1"/>
    <dbReference type="STRING" id="59895.A0A103XFH1"/>
    <dbReference type="Gramene" id="KVH89699">
        <property type="protein sequence ID" value="KVH89699"/>
        <property type="gene ID" value="Ccrd_008307"/>
    </dbReference>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="166" mass="18326" checksum="FA2B573AA88149CE" modified="2016-04-13" version="1">MPGLTIGDSLPNLQVDTTHGAIKLHDYVADSFTIIFSHPGDFTPVCTTELGAMAAYAHKFKERGVKLLGLSCDDVQSHKEWIKDIEAYNNGKKVTYPIAADPTREIIKQLNMASKHKIATPANWKDGEEVVIAPSVSNDEARKLFPGGFKTADLPSKKDYIRFTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHA5</accession>
    <name>A0A103XHA5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndetin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005096">
        <property type="protein sequence ID" value="KVH90726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHA5"/>
    <dbReference type="STRING" id="59895.A0A103XHA5"/>
    <dbReference type="Gramene" id="KVH90726">
        <property type="protein sequence ID" value="KVH90726"/>
        <property type="gene ID" value="Ccrd_007261"/>
    </dbReference>
    <dbReference type="OMA" id="GMSQIHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="148"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="933"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135312" checksum="772FF2505D07B701" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIR2</accession>
    <name>A0A103XIR2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_006486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004942">
        <property type="protein sequence ID" value="KVH91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIR2"/>
    <dbReference type="Gramene" id="KVH91488">
        <property type="protein sequence ID" value="KVH91488"/>
        <property type="gene ID" value="Ccrd_006486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="157" mass="17601" checksum="5D14A34613AD17ED" modified="2016-04-13" version="1" fragment="single">YGRAVIAIGSSHPVFHSSSCDYDKTFVRLLLPQPYPKTEVQDSDHYCHPTPTAACRPSGDETHERFIGGAPWTLSQKLYLAVSVYFVWQESNQRILTNLKRNNDQLVLEIKNVVMARIAWKANQMGKVAISHGVTAGVREGFDLVSTVVTTIIRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ65</accession>
    <name>A0A103XJ65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_006299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004912">
        <property type="protein sequence ID" value="KVH91669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ65"/>
    <dbReference type="STRING" id="59895.A0A103XJ65"/>
    <dbReference type="Gramene" id="KVH91669">
        <property type="protein sequence ID" value="KVH91669"/>
        <property type="gene ID" value="Ccrd_006299"/>
    </dbReference>
    <dbReference type="OMA" id="HTAIIME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47650">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47650:SF2">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="504"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="630"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH91669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="701" mass="78720" checksum="32669D99FB037E62" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKD4</accession>
    <name>A0A103XKD4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004820">
        <property type="protein sequence ID" value="KVH92373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKD4"/>
    <dbReference type="STRING" id="59895.A0A103XKD4"/>
    <dbReference type="Gramene" id="KVH92373">
        <property type="protein sequence ID" value="KVH92373"/>
        <property type="gene ID" value="Ccrd_005560"/>
    </dbReference>
    <dbReference type="OMA" id="REQPVVY"/>
    <dbReference type="OrthoDB" id="1938580at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053198">
        <property type="entry name" value="Gynoecium_Dev_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066">
        <property type="entry name" value="OS05G0427100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066:SF60">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="286" mass="32011" checksum="EE66D32C96A5B793" modified="2016-04-13" version="1">MEKVKLMCSYGGKIHHRPHDRQLSYVGGDTKILTIDRNINFSNLLAKLNALCDYYYEIRLKYKLPGQDLDALISIFDDDDVENMMFEYDLLRRISATPPRLRLFVFFQMATTTTTPVASRSVNPDFLFGFDKEYSLNYTTVVKNPEDKDTVVSPPENVGIADGVQKQIQEIPVPVLDNRTMTHGSYVFPTPFVYRAPMPSSGYFQAGEYRGVGNREQPVVYSFIPGGNREQPVGYGFIPVVAQEQPNIPMSGSPLSYDAARGESQLPTVMMGATCNHDGTGAQHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XL82</accession>
    <name>A0A103XL82_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome c1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_005103</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="15">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004804">
        <property type="protein sequence ID" value="KVH92841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XL82"/>
    <dbReference type="STRING" id="59895.A0A103XL82"/>
    <dbReference type="Gramene" id="KVH92841">
        <property type="protein sequence ID" value="KVH92841"/>
        <property type="gene ID" value="Ccrd_005103"/>
    </dbReference>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="15">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH92841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="370" mass="40975" checksum="5B78C8EC797C582C" modified="2016-04-13" version="1">MDWALYQALAHPKLVSFSYKQKSNGRLVVVLVLVVVVVGRSPSVWAIDSFLHLLPYRISLRQLYAARYDYDYDYFFLTHPAPPALSSLISKKEQDASGSAGMKSLRAIALLGAGVSGLLSFTTIAAADEAEHGLECPSYPWPHQGILSSYDHASIRRGHQVYTQVCASCHSMGLISYRDLVGVAYTEEETKGMAAEIEVVDGPNDEGEMFTRPGKLSDRFPQPYANEQAARFANGGAYPPDLSLITKARHNGQNYVFALLTGYRDPPAGVSIREGLHYNPYFPGGAIAMPKMLNDGAVEYEDGTPATEAQMGKDVVSFLSWAAEPEMEERKLMGFKWIFVLSLALLQAGYYRRMRWSVLKSRKLVLDVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLB4</accession>
    <name>A0A103XLB4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_005047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004802">
        <property type="protein sequence ID" value="KVH92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLB4"/>
    <dbReference type="STRING" id="59895.A0A103XLB4"/>
    <dbReference type="Gramene" id="KVH92915">
        <property type="protein sequence ID" value="KVH92915"/>
        <property type="gene ID" value="Ccrd_005047"/>
    </dbReference>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10540" checksum="59A2E3DB930887FD" modified="2016-04-13" version="1" fragment="single">EEEDEEEEDEKGRWRAVASWTWDAHDETCGICRMAFDGCCPDCKLPGDDCPLIWGACNHAFHLHCILKWVNSQTPQAHCPMCRREWQFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMK5</accession>
    <name>A0A103XMK5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_004699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the poly(A) tail of mRNA in nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polyadenylate-binding RBP47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004788">
        <property type="protein sequence ID" value="KVH93254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMK5"/>
    <dbReference type="STRING" id="59895.A0A103XMK5"/>
    <dbReference type="Gramene" id="KVH93254">
        <property type="protein sequence ID" value="KVH93254"/>
        <property type="gene ID" value="Ccrd_004699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12345">
        <property type="entry name" value="RRM2_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000737">
        <property type="entry name" value="polyadenylate-binding protein RBP47 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000144">
        <property type="entry name" value="Polyadenylate-binding protein RBP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF63">
        <property type="entry name" value="NUCLEOTIDE-BINDING ALPHA-BETA PLAIT DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH93254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="45665" checksum="E1CF08AB6DA6A9EA" modified="2016-04-13" version="1">MQPTNGSGGDLTQQQQQQQQQQWLAMQQYQQQQWLAMQQYPAAAAASMAMHHPAMMYQQPPPHYMPYHYQQQQYQQQSPQQQRGNQIQSSSEDNKTIWVGDLQHWMDETYLQSCFAQTGEVSSIKLIRNKQTGQSERYGFIEFVSHEAAEKVLQSYNGTMMPNTDQAFRLNWASFSTGEKRADTGSDLSIFIGDLAPDVTDTILYETFAGRYPSVKGAKVVVDTNTGCSKGYGFVRFGDENERTRAMNEMNGQYCSSRPMRIGVATPKKPPTQQQYGQGQQQYSSQAVLLTGGSGSFGAMPQNSQSDGDSSNTTERASFLVGISVHRSSAEDAIQNMHGTVIGKQTVRISWGKTPANRQRMGSNGNYYVKQGYGGGGGYGYGVPQNQDAGMYAAGDASAYGSNGYDNHQQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XML2</accession>
    <name>A0A103XML2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004756">
        <property type="protein sequence ID" value="KVH93500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XML2"/>
    <dbReference type="STRING" id="59895.A0A103XML2"/>
    <dbReference type="Gramene" id="KVH93500">
        <property type="protein sequence ID" value="KVH93500"/>
        <property type="gene ID" value="Ccrd_004448"/>
    </dbReference>
    <dbReference type="OMA" id="YSHFAIH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090069">
        <property type="term" value="P:regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000016">
        <property type="entry name" value="Protein arginine N-methyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF89">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="629" mass="69133" checksum="82D203DDD9D646B9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMQ6</accession>
    <name>A0A103XMQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lipase/lipooxygenase, PLAT/LH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_004358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004727">
        <property type="protein sequence ID" value="KVH93590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMQ6"/>
    <dbReference type="STRING" id="59895.A0A103XMQ6"/>
    <dbReference type="Gramene" id="KVH93590">
        <property type="protein sequence ID" value="KVH93590"/>
        <property type="gene ID" value="Ccrd_004358"/>
    </dbReference>
    <dbReference type="OMA" id="NNDERWK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990136">
        <property type="term" value="F:linoleate 9S-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010311">
        <property type="term" value="P:lateral root formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900366">
        <property type="term" value="P:negative regulation of defense response to insect"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.372.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.375.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="11">
        <location>
            <begin position="139"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH93590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="755" mass="85625" checksum="C07366AF1E5A846E" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMV5</accession>
    <name>A0A103XMV5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UbiA prenyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_004301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004659">
        <property type="protein sequence ID" value="KVH93647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMV5"/>
    <dbReference type="STRING" id="59895.A0A103XMV5"/>
    <dbReference type="Gramene" id="KVH93647">
        <property type="protein sequence ID" value="KVH93647"/>
        <property type="gene ID" value="Ccrd_004301"/>
    </dbReference>
    <dbReference type="OMA" id="IVQLGFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13960">
        <property type="entry name" value="PT_UbiA_HPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044502">
        <property type="entry name" value="AtHST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43009:SF6">
        <property type="entry name" value="HOMOGENTISATE PHYTYLTRANSFERASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43009">
        <property type="entry name" value="HOMOGENTISATE SOLANESYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH93647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="38524" checksum="52E0F513A0481D36" modified="2016-04-13" version="1">MQIMKSLIIGSFPNKVSSYSPSLPDSYTSLISTGSFHVSLRASKLKQSQPNLVRYSNGSFNESSLLSRKCNTRHVANAVSEQPMEPDSTNPQNSLPNALNAFYRFSRPHTVIGTAIVAAFFMNIYIVGLNQLSDIEIDKVNKPYLPLASGEYSVQTGVIIVSSFAVMSFWLGWIVGSWPLFCALLISFLLGTAYSINVPMLRWKRFALVAAMCILATFVYGRLAVFPKSVIFATGFMSFFSVDIPDIVGDKIFGIQSFTVRLGQKRVFWICILLLEVAYGVAILVGASSPFLWSRYITILGHAILGLILWGRAKSTDLDSKSAITSFYMFIWQLFYAEYLLIPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN26</accession>
    <name>A0A103XN26_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_004322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004705">
        <property type="protein sequence ID" value="KVH93628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN26"/>
    <dbReference type="STRING" id="59895.A0A103XN26"/>
    <dbReference type="Gramene" id="KVH93628">
        <property type="protein sequence ID" value="KVH93628"/>
        <property type="gene ID" value="Ccrd_004322"/>
    </dbReference>
    <dbReference type="OMA" id="IMRLAMS"/>
    <dbReference type="OrthoDB" id="1922093at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11444">
        <property type="entry name" value="bHLH_AtIBH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044549">
        <property type="entry name" value="bHLH_AtIBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044660">
        <property type="entry name" value="IBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059002">
        <property type="entry name" value="IBH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124:SF110">
        <property type="entry name" value="MYC-TYPE, BASIC HELIX-LOOP-HELIX (BHLH) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124">
        <property type="entry name" value="TRANSCRIPTION FACTOR IBH1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26576">
        <property type="entry name" value="IBH1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IBH1-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH93628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20738" checksum="BCB584861CE1EC39" modified="2016-04-13" version="1">MHNSSQLRKEFIKKWIHGLQICCSSKKHMNLMERKKKIKLSADIALASAKNATTSWSKALIADVKIDEENMILINNLSGPESKFVGAHDQRVTCHKRIRSKKILKKSCGVGKRIKRMGSRRSDLATCIAERLVKKRTKVLKRLVPGGESMDEVTIIKEALDYILSLRVQVDVMKNVVNATGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ70</accession>
    <name>A0A103XQ70_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004518">
        <property type="protein sequence ID" value="KVH94813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ70"/>
    <dbReference type="Gramene" id="KVH94813">
        <property type="protein sequence ID" value="KVH94813"/>
        <property type="gene ID" value="Ccrd_003116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="377" mass="42385" checksum="ED95CC77478D39F0" modified="2016-04-13" version="1">MRDIWFWNMIYDYDQPLLIENGPSNGVLQHEKLVRSFIRHASSEEIAKMRIPLLCYVNTLTGNDRARSCGMLCALTSICSFLLQRMKWGYSANYGCGVLGRWDTINARVVNPVWFALETTAQIDYKRRGALRAKHISLDSRRKKKMKHILDLPYEILTTILIMLASSSDGAGDIARISTTCIRFMSLASQPHVLKAVNFRSLTSTEDYEPHHNLNGLLCQCAEAGNLAAEAMLGRALLFNDYWFWNVLMDDNQPLIAREGPASGVLLHEKLVRSFIAYSSCQDMAPMRIPLFSYMISFLGYDVARECGILLAVTNLCSYEIIRLNVRSLSNIPENSGNNVSVSGLSNAMARLTPPSGATHRERLLALFDEFFPSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRQ3</accession>
    <name>A0A103XRQ3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribulose bisphosphate carboxylase large chain</fullName>
            <ecNumber evidence="3">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_002269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = D-ribulose 1,5-bisphosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 1,5-bisphosphate + O2 = 2-phosphoglycolate + (2R)-3-phosphoglycerate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuBisCO large chain family. Type I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004380">
        <property type="protein sequence ID" value="KVH95656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRQ3"/>
    <dbReference type="Gramene" id="KVH95656">
        <property type="protein sequence ID" value="KVH95656"/>
        <property type="gene ID" value="Ccrd_002269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="entry name" value="RuBisCO large subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="RuBisCO, large subunit, small (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="11" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH95656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="196" mass="21955" checksum="9E08FD4267DC8B79" modified="2016-04-13" version="1">MLNNSGMPIQKARKQIDQNGNVFGFKALRALRLEDLRIPTAYFIIKGSTESSIYVQSLPEIAPMRLSAHDFQDVVADNGFSHKEGEVTSSRFLGDGVALPPIELEWRSSAMARFGLKASFEIAVDCSPSRLRLRLPSNRAISRFKVQIYLYSNCKPKASGSPFIENGCPKVLLLYDSKKPLRKIKSAVLLKQHEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSB3</accession>
    <name>A0A103XSB3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSB3"/>
    <dbReference type="STRING" id="59895.A0A103XSB3"/>
    <dbReference type="Gramene" id="KVH95985">
        <property type="protein sequence ID" value="KVH95985"/>
        <property type="gene ID" value="Ccrd_001931"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00186">
        <property type="reaction ID" value="UER00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="9834" checksum="9B7AAE8281E950F2" modified="2016-04-13" version="1">MHHEPEIMFETLKHRIEEYVHDEDNMGGATVAGGIAQSFHNMPYLTIGSSCCLTAANGNNGYYYCSDEDFTAGADEVASEDDQWSYVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSI3</accession>
    <name>A0A103XSI3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(ADP-ribose) polymerase, regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004360">
        <property type="protein sequence ID" value="KVH96092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSI3"/>
    <dbReference type="STRING" id="59895.A0A103XSI3"/>
    <dbReference type="Gramene" id="KVH96092">
        <property type="protein sequence ID" value="KVH96092"/>
        <property type="gene ID" value="Ccrd_001824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="94" mass="11143" checksum="2867979ADF347CC7" modified="2016-04-13" version="1" fragment="single">SKTPIEAPRRRLRPPRRRLRPPRRRLKPPTRSIARYDYSIAFRVQEKPSSKMEIQPRETKLEARVAKFISLICNVSMMKQQMMEIGLFPIPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUW2</accession>
    <name>A0A103XUW2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003845">
        <property type="protein sequence ID" value="KVH97275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUW2"/>
    <dbReference type="STRING" id="59895.A0A103XUW2"/>
    <dbReference type="Gramene" id="KVH97275">
        <property type="protein sequence ID" value="KVH97275"/>
        <property type="gene ID" value="Ccrd_000621"/>
    </dbReference>
    <dbReference type="OMA" id="ENFFQWD"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000030">
        <property type="entry name" value="F-box/kelch-repeat protein At3g61590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000076">
        <property type="entry name" value="F-box/kelch-repeat protein At3g61590 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056592">
        <property type="entry name" value="Beta-prop_At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24750">
        <property type="entry name" value="b-prop_At3g26010-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="47006" checksum="F0E4F7D1CED70E80" modified="2016-04-13" version="1">MKGETSWVSHCVDDKSKDNEDFDSFAEVNDEVNKDNSPVISVDLILPDDLLERIVAYLPIASIFRVGCVCKRWHEIVSSRRFLWNVSPVLSQKPWYFMFTSSDEPIGYAYDPVLRKWYGIELPYMVKTSRWFIASSSGLVCFMDNDSRSELYVCNLITKCCFRLREPPGLRFCDYSALAISVDRISTNYTVTVVKSRQVPENYLQWDLSVHVYDSVTMMWTTIVTEMLMGWRGGDESVICNGVLYFLIYSIGSFQEHRHGLVSCNLSSRSSSSSSRNVLTRDFVSVPCSLTCGRLMNLKGSLVMVGGIGKQDRQDIIIGIGIWVLEDGKEWREVGRMPHKFFQGFGELDDVFASSGTDDLIYIQSYGAPALLVFDLKKKQWRWSQKCPVTKRFPLQLFSGFCFEPRLEISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XV51</accession>
    <name>A0A103XV51_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Selenoprotein SelK/SelG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003831">
        <property type="protein sequence ID" value="KVH97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XV51"/>
    <dbReference type="STRING" id="59895.A0A103XV51"/>
    <dbReference type="Gramene" id="KVH97475">
        <property type="protein sequence ID" value="KVH97475"/>
        <property type="gene ID" value="Ccrd_000442"/>
    </dbReference>
    <dbReference type="OMA" id="VAKRSPW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024491">
        <property type="entry name" value="Se_SelK/SelG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16875">
        <property type="entry name" value="SELENOPROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16875:SF0">
        <property type="entry name" value="SELENOPROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10961">
        <property type="entry name" value="SelK_SelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="98" mass="10591" checksum="7516078F3BAB5CA2" modified="2016-04-13" version="1">MAYVERGVVKSSRSIWRLRTIIDFFWAIIAFIRVFFATMFSMEKSDGYKKLSGSSKKWDGGGPGGPYGGGPRGPPRGLDNVRGIDHNSLPACGSCCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVC4</accession>
    <name>A0A103XVC4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IST1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003824">
        <property type="protein sequence ID" value="KVH97581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVC4"/>
    <dbReference type="STRING" id="59895.A0A103XVC4"/>
    <dbReference type="Gramene" id="KVH97581">
        <property type="protein sequence ID" value="KVH97581"/>
        <property type="gene ID" value="Ccrd_000301"/>
    </dbReference>
    <dbReference type="OMA" id="IRERFEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF16">
        <property type="entry name" value="REGULATOR OF VPS4 ACTIVITY IN THE MVB PATHWAY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52908" checksum="FBC8462160B469E5" modified="2016-04-13" version="1" fragment="single">STTISSSPQIRKAVCRRFSFVLVCLQPYLKASCFHTYRPEIKQKAMGRKLDAILGRKFKTSKFKATVNLAVSRLSILKNKRQACVAVVRSDIIELLKLNHHEHALQRVDQVIKEQNMLDVFVMMDGYCHLLLQRVSLIEHEKECPDELKEAASSLIFAAPRCGEFPELQEIRAILTSRYGKEFAKGATDLRSNCGVSTRMIQKLSPRQSTLETRMKTLQEIATENGIVLQLEDTSPVINEVAEVLSVRNGSSSRLQNNSEVLDDEVLGFSESRKGKKKFRDVEDAAQAAFESAAYAAAAARAAVELSRSGSFGSDDPDSPNSRPRKVRDSEKSKLHVRYEKNHEWESESESESKHKETVVENEGETSKNHRLARDSDGSDSDGHKTSEKGMVFDESDDEIENEPAGFSSLGNYNGGLKTEGAFTSDKQFPIRPKNAEMGLGIDERRFGEGSEIAQLDLTKKPISVRNKRVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XW93</accession>
    <name>A0A103XW93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_023725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003811">
        <property type="protein sequence ID" value="KVH98060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XW93"/>
    <dbReference type="Gramene" id="KVH98060">
        <property type="protein sequence ID" value="KVH98060"/>
        <property type="gene ID" value="Ccrd_023725"/>
    </dbReference>
    <dbReference type="OMA" id="KEPHAEN"/>
    <dbReference type="OrthoDB" id="1938818at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH98060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18225" checksum="D2879139C6BC221B" modified="2016-04-13" version="1">METERRCYGGGGAPPVAETLNWMVQTVLVAQKSVCWLLFLIGSIPNNVDASTNLLDAEKRFPLSELKNVADSADECKDDSETEDDSDDEDVVVGDDSDNDAEDSSGDDNDDEERDPDSDSDANEDAGSDDDDDDDEDDDDDEDDEDDDDDDDEEEENQPPFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWT8</accession>
    <name>A0A103XWT8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor MYC/MYB N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_023471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003802">
        <property type="protein sequence ID" value="KVH98323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWT8"/>
    <dbReference type="STRING" id="59895.A0A103XWT8"/>
    <dbReference type="Gramene" id="KVH98323">
        <property type="protein sequence ID" value="KVH98323"/>
        <property type="gene ID" value="Ccrd_023471"/>
    </dbReference>
    <dbReference type="OMA" id="CLIQHTL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46633">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYC/MYB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46633:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYC_MYB N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor MYC/MYB N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH98323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="322" mass="36051" checksum="DA2829598C8C4B42" modified="2016-04-13" version="1">MEAGLPMLTCLIQHTLKNLCTCSSSDSSSSDPKWVYAVYWRISPRIYPPPKWDYEGGVLDRAKGNKRNWILVWDDGFCDLDECERVGNHGFLKSRFGADVFFKLSHEVYNYGEGLIGKVAADNSHRWTIAIISVREGIIQLGSFDKVLEDLNLVISIQRKFSYLRSIPGLFSIQRPFSTIQHLYNPLKHKGVIGGNVIGSDEAQQVIGSKVNIRGGESQLHKGPILSFGSGYNIQEIGRTGSHGPPLWPIPPLLPSNFESQLDKMPSYNDPIRIRNDGISQVKDPDQERKHGCFDPNQNLVVELGFGPKRIAQESDVKSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XX43</accession>
    <name>A0A103XX43_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003795">
        <property type="protein sequence ID" value="KVH98464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XX43"/>
    <dbReference type="Gramene" id="KVH98464">
        <property type="protein sequence ID" value="KVH98464"/>
        <property type="gene ID" value="Ccrd_023307"/>
    </dbReference>
    <dbReference type="OMA" id="NHLSEDM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="159" mass="18274" checksum="ACBDD10DB98801A2" modified="2016-04-13" version="1">MSTSPTPPTTPELKEDAEYNKXCEKHQHLIQTLRKGNGWMVQHLYNYNGFWLSTYFIKNILLLNAFFKPQSSDVFLASFMKSGTTWLKALIFEKLSTLEVNKNGVEKFGKLMVVEKAAFFRKGEVGDWKNHLSEDMRQRIDGITDEKLKDSGLILGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXK7</accession>
    <name>A0A103XXK7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosome maturation protein SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_023008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003715">
        <property type="protein sequence ID" value="KVH98765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXK7"/>
    <dbReference type="STRING" id="59895.A0A103XXK7"/>
    <dbReference type="Gramene" id="KVH98765">
        <property type="protein sequence ID" value="KVH98765"/>
        <property type="gene ID" value="Ccrd_023008"/>
    </dbReference>
    <dbReference type="OMA" id="CYKNKVF"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH98765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="40434" checksum="548190C6B566502D" modified="2016-04-13" version="1">MSRTLVQPVGQKRLTNVAVVRLKKHGNRFEIACYKNKVLSWRSGVERDLDEVLQSHTVYTNVGKGVLAKSKDLLAAFGMDDQTKICLEILEKGELQVAGKERESQLSNQFRDIATIVMLKTINPETQRPYTISMIERLMHEIHFAVDPHSNSKKQALDVIRELQKHFPIKRSPMRLRLTLPQQNFDSLAEKLTEWKTVTVSKDESGSQVSIVCEMDPGLFRDCDAFVRNLQGRSEILAISVHGEGDIHADHYEGHEEVSSSESKKPTEDVVQLSEKIQKQTLSADDTQGQVKQNKCSTCDAIVGDAKQYREHFKSDWHKHNLKRKTRQLPPLSADECRADEEMSDSKSDLNEYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYJ0</accession>
    <name>A0A103XYJ0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BSD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003629">
        <property type="protein sequence ID" value="KVH99257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYJ0"/>
    <dbReference type="STRING" id="59895.A0A103XYJ0"/>
    <dbReference type="Gramene" id="KVH99257">
        <property type="protein sequence ID" value="KVH99257"/>
        <property type="gene ID" value="Ccrd_022511"/>
    </dbReference>
    <dbReference type="OMA" id="VCTCELL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="580" mass="65844" checksum="84C1E4E145AC50AE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZG0</accession>
    <name>A0A103XZG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003423">
        <property type="protein sequence ID" value="KVH99660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZG0"/>
    <dbReference type="STRING" id="59895.A0A103XZG0"/>
    <dbReference type="Gramene" id="KVH99660">
        <property type="protein sequence ID" value="KVH99660"/>
        <property type="gene ID" value="Ccrd_022096"/>
    </dbReference>
    <dbReference type="OMA" id="KNDDRHP"/>
    <dbReference type="OrthoDB" id="1938580at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000058">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053198">
        <property type="entry name" value="Gynoecium_Dev_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066:SF85">
        <property type="entry name" value="OS02G0809100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066">
        <property type="entry name" value="OS05G0427100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="473" mass="51802" checksum="92EAFF7843AC8159" modified="2016-04-13" version="1">MENNYSYSSYPDSNTSTPRSREVDCETASYDEQVANNPNPNNNNNASSNYKVKLMCSYGGKILPRPHDNQLTYIGGDTKILTVDRNIRYGSILHKLNSLSDSSDICFKYQLPGEDLDALISVTNDEDLEHMMTEYDRIFRSSAKPVRLRLFMFSLSPATFGGGGGGESKTEQQWFVDALNAVQISSGQSSSPASDNPDYLFGFDKGNAPVTAQAKVQDVTAVVVPQANVSDTTRPGSECGSEDSNSNRHVVGDTVVSPTVEIQRQIQESQRMQIAASHEQAINIDPRAYYGDYYPQKIQPAAATGQPRYWQERHMTTGGYPMSVAGNDSPVYLIPSSTGVYPSPTPPAQAPPAAQTLRQATGQVSQGQAYYGMQRMGNPPEFYREQPMYSTMNQPPIQQTKVGTYPEAIGVVRPQAELGYGQVGIDATGRQVYYTTSQGMNSPYQQVMAPTDVRQGPGLVVNPEGKMVLNPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0V9</accession>
    <name>A0A103Y0V9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003388">
        <property type="protein sequence ID" value="KVI00455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0V9"/>
    <dbReference type="STRING" id="59895.A0A103Y0V9"/>
    <dbReference type="Gramene" id="KVI00455">
        <property type="protein sequence ID" value="KVI00455"/>
        <property type="gene ID" value="Ccrd_021292"/>
    </dbReference>
    <dbReference type="OMA" id="HAKRIWA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000009">
        <property type="entry name" value="probable transcription factor PosF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690:SF152">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690">
        <property type="entry name" value="TRANSCRIPTION FACTOR POSF21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="409" mass="45494" checksum="E3D40715ADE40D60" modified="2016-04-13" version="1">MEKDESQNLNGSLLPPSGWNSGFPLDGNKDNEKSEPNGSTMVPTNCDESDQLTHDLSRMLDHPPKYLGHRRALSEIVTLPDDISFDRDLGVVGGFNGPSYSDETEEDLLSMYLDHMDKLNNSSATSGSQVGESSFSAVQNSQTAATPPASPPPENHVTSIRVKHQHSMSMDGSAIKPEMLNSGSEEISSTDAKKSISDAKLAELALVDPKHAKRIWANRQSAARSKERKMRYIAELERKVQILQTEASSCSAQLALLQRDTNAFNDALKEEIHRLKILTGQNLMNGGSMMNFRQSFGANYQFHPSNHAMNTQQFQQLQNQHPFEQQQLPLLHQIQQHPFQEQQLLQIQQKHQHPYPQQPGHRSSFHVIHGSDFVKTYDQTFTTTAATSFQKPAAQPTIAPPGNTGYGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y128</accession>
    <name>A0A103Y128_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003377">
        <property type="protein sequence ID" value="KVI00550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y128"/>
    <dbReference type="STRING" id="59895.A0A103Y128"/>
    <dbReference type="Gramene" id="KVI00550">
        <property type="protein sequence ID" value="KVI00550"/>
        <property type="gene ID" value="Ccrd_021204"/>
    </dbReference>
    <dbReference type="OMA" id="SEMRRPY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000187">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000310">
        <property type="entry name" value="RNA recognition water-stress protein1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="223"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="303"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="781" mass="86234" checksum="339953D7CD3EA8C3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1M2</accession>
    <name>A0A103Y1M2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purple acid phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_020884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01003209">
        <property type="protein sequence ID" value="KVI00859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1M2"/>
    <dbReference type="Gramene" id="KVI00859">
        <property type="protein sequence ID" value="KVI00859"/>
        <property type="gene ID" value="Ccrd_020884"/>
    </dbReference>
    <dbReference type="OMA" id="CILRRTH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040974">
        <property type="entry name" value="Fn3_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778:SF3">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17808">
        <property type="entry name" value="fn3_PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006989426" description="Purple acid phosphatase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase Fn3-like" evidence="12">
        <location>
            <begin position="71"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="11">
        <location>
            <begin position="212"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="322"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI00859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="614" mass="68050" checksum="58FD71321531A61B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1Q2</accession>
    <name>A0A103Y1Q2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Urease accessory protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_020839</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">URED, UREF and UREG may form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003180">
        <property type="protein sequence ID" value="KVI00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1Q2"/>
    <dbReference type="STRING" id="59895.A0A103Y1Q2"/>
    <dbReference type="Gramene" id="KVI00899">
        <property type="protein sequence ID" value="KVI00899"/>
        <property type="gene ID" value="Ccrd_020839"/>
    </dbReference>
    <dbReference type="OMA" id="KMRGDKP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="10">
        <location>
            <begin position="68"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="268" mass="29075" checksum="202CE98CD5BB9508" modified="2016-04-13" version="1">MKNNKAVVTTKNKRNTNGESSWVGKDGKVYHSHDGLAPHSHEPIYSPGFFSRRAPPLVTRDFNERAFTIGIGGPVGTGKTALMLALCKQLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGPLEELSNLYKTDILLCESGGDNLAANFSRELADYIIYIIDVSGGDKIPRKGGPGITQADLLVINKTDLAAAVGADLAVMERDALRMRDGGPFVFAQVKHGVGVEEIVDNILQAWEATTNSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3Z3</accession>
    <name>A0A103Y3Z3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_019673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002665">
        <property type="protein sequence ID" value="KVI02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3Z3"/>
    <dbReference type="STRING" id="59895.A0A103Y3Z3"/>
    <dbReference type="Gramene" id="KVI02049">
        <property type="protein sequence ID" value="KVI02049"/>
        <property type="gene ID" value="Ccrd_019673"/>
    </dbReference>
    <dbReference type="OMA" id="CWELVLA"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16987">
        <property type="entry name" value="ANTH_N_AP180_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000019">
        <property type="entry name" value="Clathrin coat assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000005">
        <property type="entry name" value="putative clathrin assembly protein At2g25430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF75">
        <property type="entry name" value="CLATHRIN COAT ASSEMBLY PROTEIN AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="10">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="691" mass="78423" checksum="065F38F1D7BAA44B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y447</accession>
    <name>A0A103Y447_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002661">
        <property type="protein sequence ID" value="KVI02165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y447"/>
    <dbReference type="STRING" id="59895.A0A103Y447"/>
    <dbReference type="Gramene" id="KVI02165">
        <property type="protein sequence ID" value="KVI02165"/>
        <property type="gene ID" value="Ccrd_019560"/>
    </dbReference>
    <dbReference type="OMA" id="MFDAFHF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006943">
        <property type="entry name" value="DUF641_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056813">
        <property type="entry name" value="GIL1_IRKI_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04859">
        <property type="entry name" value="DUF641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24994">
        <property type="entry name" value="GIL1_IRKI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF641" evidence="1">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GIL1/IRKI C-terminal" evidence="2">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="377" mass="43703" checksum="CECF8C0432E29445" modified="2016-04-13" version="1">MDSVQHSSNKSRLARTFAKLQYAQFPYDGEGIQSADQIVVSELKNLSELKQCFLKKHLDDSSPETTQLVAEVQEQKNLLKTYEITRKKLNSYTKLKDSEIMFLKEKLEESRRENKVIEKRLSSSGSLSSSLHENLDFHSLTPTNFVSALKQTMKSIRNLVRFLISEMESANWDLDEAADSIQPDVVYWDTTHKCYAFESFICREMFDGFNLPEFRITSDYQSMPRSEKRQRFFDKFMELKSLKAREYLTWKPTSMFAEFCRSKYLKLVHPKMEFSLFGNLNQRNLVGARKFPETAFFDLFADVAKRVWLLHCLAFSFGPEEVGIFQVAKSSRFSEVYMESVNEEALLSPESSSVVAFTVVPGFRVGKTVIQCQVYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4Y4</accession>
    <name>A0A103Y4Y4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002651">
        <property type="protein sequence ID" value="KVI02590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4Y4"/>
    <dbReference type="Gramene" id="KVI02590">
        <property type="protein sequence ID" value="KVI02590"/>
        <property type="gene ID" value="Ccrd_019120"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="208"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="427" mass="47674" checksum="91F89B3771D70E67" modified="2016-04-13" version="1">MAHGETGGTEIIDVKTLSKGEDYTEIVNGKIGLSGSTSLDAKMVSKVEDYVNIVNSETITPATTTHDAKCTVLQNESNQVSEIRKPSVVENLNSQSITEDLETASIDVNDEASRKRKRQLARDKKAAIVILNPHDNIGDTEIANSGSGHLPSLEGLAAQSHIDGGKQIDKNMVRSLYAKMTIEDVEIPKDQNLGDSSLKDFVMRNHVAMSRKKLLVLDVNGLLADIIFPPPKDCKSDKNILRRAIFKRPFLDGFLGFCFENFEVAIWSSRTRKILDPVVDYLLGDLKKQLLFLWDLSYCTNSSARSLENKHKFIVFKELRKIWEQNGHNLASENGYYDESNTLLLDDSPYKALLNPKHTGIFPLSYSYMDINDNSLGPDGDLRGYLEGVAATEDVKMYLQQHPFGQPAIDETSSHWAFYSGVLERDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5F2</accession>
    <name>A0A103Y5F2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_018869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5F2"/>
    <dbReference type="Gramene" id="KVI02829">
        <property type="protein sequence ID" value="KVI02829"/>
        <property type="gene ID" value="Ccrd_018869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36410:SF4">
        <property type="entry name" value="DEHYDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36410">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20252" checksum="A511FD2234A3CEDD" modified="2016-04-13" version="1">MFTTIRSVSVQAKPVAGSWIFTVSENFAGKVSPTIGNVRSHQASASPGSGPAITNQTKPTNMEKIQHSQEPTTKGRDVMSHTFGDAYSTRSDEQGFGGAFTGNESLSSTEQDKIVNANAPDEEVPQSLLKSLLRHNKRLLQENRDLTVEISVLRSKLANKKTKMFCEREPTVKGLLENCRIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5F4</accession>
    <name>A0A103Y5F4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubby-like F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_018856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002623">
        <property type="protein sequence ID" value="KVI02847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5F4"/>
    <dbReference type="STRING" id="59895.A0A103Y5F4"/>
    <dbReference type="Gramene" id="KVI02847">
        <property type="protein sequence ID" value="KVI02847"/>
        <property type="gene ID" value="Ccrd_018856"/>
    </dbReference>
    <dbReference type="OMA" id="TWPARNV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22153">
        <property type="entry name" value="F-box_AtTLP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF134">
        <property type="entry name" value="TUBBY-LIKE F-BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="46248" checksum="3C414046B9742CA5" modified="2016-04-13" version="1">MSFKSIVRELREMRDGIGNISRRGIEGRHWRNRTRSHIAPDVAPSELINQGQWANLPPELLLDIIRRVEESETSWPARTVVVYCASVCKSWRDITKEIVKTPEECGRLTFPISLKQPGPRDSPIQCYIRRDRATSTHRLYFGLTPSEDESDKLLLAAKKIRRATSTEFAISLVADDFSRASSTYIGKLRQVSNFLGTKFTIYDSQSPSDASVQANHNRSSQRFHKKQVSPRIPACSYSIATISYELNVLRTRGPRRMNCVMHSIPISSIQEGGSAPTPKSFPHSFDDKHSLSSPSFKGKDPSNVRSTSCLSGPICVDPLMLKNKAPRWHEQLQCWCLNFKGRVTVASVKNFQLVASVDPSHNVSAAEQDKVILQFGKIGKDIFTMDYRYPLSAYQAFAICLSSFDTKPACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5Z5</accession>
    <name>A0A103Y5Z5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectinesterase</fullName>
            <ecNumber evidence="5 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_018582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 13"/>
    <dbReference type="EMBL" id="LEKV01002523">
        <property type="protein sequence ID" value="KVI03124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5Z5"/>
    <dbReference type="STRING" id="59895.A0A103Y5Z5"/>
    <dbReference type="Gramene" id="KVI03124">
        <property type="protein sequence ID" value="KVI03124"/>
        <property type="gene ID" value="Ccrd_018582"/>
    </dbReference>
    <dbReference type="OMA" id="YSEFQNF"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000029">
        <property type="entry name" value="Pectinesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="15">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI03124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="525" mass="58161" checksum="DC44625A689FB00A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y614</accession>
    <name>A0A103Y614_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_018526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NPR1-like' subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002425">
        <property type="protein sequence ID" value="KVI03179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y614"/>
    <dbReference type="STRING" id="59895.A0A103Y614"/>
    <dbReference type="Gramene" id="KVI03179">
        <property type="protein sequence ID" value="KVI03179"/>
        <property type="gene ID" value="Ccrd_018526"/>
    </dbReference>
    <dbReference type="OMA" id="CPHDACR"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000031">
        <property type="term" value="P:regulation of salicylic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009862">
        <property type="term" value="P:systemic acquired resistance, salicylic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18310">
        <property type="entry name" value="BTB_POZ_NPR_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000110">
        <property type="entry name" value="Regulatory protein NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000123">
        <property type="entry name" value="regulatory protein NPR3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044292">
        <property type="entry name" value="NPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021094">
        <property type="entry name" value="NPR1/NIM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057250">
        <property type="entry name" value="Znf_C2HC_NPR-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46475:SF10">
        <property type="entry name" value="CHROMATIN REMODELING &amp; TRANSCRIPTION REGULATOR ABTB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46475">
        <property type="entry name" value="REGULATORY PROTEIN NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12313">
        <property type="entry name" value="NPR1_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52046">
        <property type="entry name" value="ZF_C2HC_NPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="64"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC NPR-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI03179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="579" mass="64984" checksum="51E3060AE2F1C1ED" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y732</accession>
    <name>A0A103Y732_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_017997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002333">
        <property type="protein sequence ID" value="KVI03724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y732"/>
    <dbReference type="STRING" id="59895.A0A103Y732"/>
    <dbReference type="Gramene" id="KVI03724">
        <property type="protein sequence ID" value="KVI03724"/>
        <property type="gene ID" value="Ccrd_017997"/>
    </dbReference>
    <dbReference type="OMA" id="MYNSQHQ"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000188">
        <property type="entry name" value="Mitochondrial RNA-splicing protein MRS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF11">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI03724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35676" checksum="1576845B53ACE3E4" modified="2016-04-13" version="1">MATTEAAKFKKSDLIPIPQPPDYHPEITVSPAHDGLHFWQFMIAGSIAGMVEHMAMFPIDTIKTRMQVLGSCPIKSVGLRQALQSILKSDGPAGLYRGIGAMGLGAGPAHAVYFSVYEMCKEAFSRQHPNNPVAHAAAGVFATVASDAVFTPMDMVKQRLQLGSGSPYKGVFDCVRTVLKEEGFGAFYASYRTTILMNAPFTAVHFATYEAAKRGLLGVSPDIAGDERLVVHATAGAAAGALAAAVTTPLDVVKTQLQCQGVCGCDRYVNGSIRDVLRTIVKKDGYRGLLRGWMPRMMFHAPAAAICWSTYEAGKSFFQELNSDDRSSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7A8</accession>
    <name>A0A103Y7A8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002324">
        <property type="protein sequence ID" value="KVI03844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7A8"/>
    <dbReference type="Gramene" id="KVI03844">
        <property type="protein sequence ID" value="KVI03844"/>
        <property type="gene ID" value="Ccrd_017851"/>
    </dbReference>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036469">
        <property type="term" value="F:L-tryptophan decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006587">
        <property type="term" value="P:serotonin biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="430" mass="47762" checksum="0ED7FB21283F643C" modified="2016-04-13" version="1">MDDGLNLKAMDAEQLREYGHKMVDFIADYYKNIETFPVLSQVEPGYLHKLLPDSAPMQPESLETVLQDVQTKILPGVTHWQSPDYFAYFPSNSSVAGFLGEMLSAGINIVGFSWITSPAATELEMIVLDWLANLLKLPNDFLSKGPGGGAIQGTASEALLVVLLAARDKVLREVXKDALGRLVVYGSDQTHSSLLKACQIAGIHSKNCRLLKTETCNEYALSPESLTDAISHDIASGLIPLFLCATRNNMWFHVDAAYAGSACICPEYRHHLNGIEEADSFNMNCHKWFLTNFDCSALWIKDRNALIQSLSTNPEYLKNKAYIRNHINLAKHFGDLVAQDPRFEIVATRTFSLVCFRLLPANKNEDXVNELNRDLLDAINSSGKIFISHTVLSGKYVLRFVVGAPLTEERHVVAAWKLFQEAASTLLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7B0</accession>
    <name>A0A103Y7B0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_017865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002327">
        <property type="protein sequence ID" value="KVI03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7B0"/>
    <dbReference type="Gramene" id="KVI03831">
        <property type="protein sequence ID" value="KVI03831"/>
        <property type="gene ID" value="Ccrd_017865"/>
    </dbReference>
    <dbReference type="OMA" id="VPRMTEY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000731">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF11">
        <property type="entry name" value="KINASE-LIKE PROTEIN TMKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="165"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="47108" checksum="BCFFA31F42072E56" modified="2016-04-13" version="1">MGQNEFTGSIPEYISGFRGLRQLDLSSNNFSGLIPDDLSKLPLDKLNLSYNNLSGVLPNFGESKFGSDSFEGNPSLCGPPLKLCKQGSKGGLSSGAVAGLVISLMTGVVVFASLLIGYSQGKRKKNLDEEEEEFEDGEDDENGGGEGKLILFQGGEHLTLEDVLNATGQVMEKTSYGTIYKAKLADGGTIALRLLREGSCRDGGCCLPAIRQLGRIRHENLIPLRAFYQGKRGEKLRHKIALGIAKGLAHLHSSIETPITHGNVRSRNVLVDDFFVARLTDFGLYKLMIPAVADEIIAAAKTGGYKAPELQKMKNCNSRTDVYAFGILLLEILLGKKPGKNGGREGFVDLPAAVKVAVLEETTMEVFDVEVLKGIRSPMEDGVVQALKLAMGCCAPVASVRPSMEEVVKQLEENRPRNRSALYSPAETRSEIGTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7P9</accession>
    <name>A0A103Y7P9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_017632</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002312">
        <property type="protein sequence ID" value="KVI04055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7P9"/>
    <dbReference type="STRING" id="59895.A0A103Y7P9"/>
    <dbReference type="Gramene" id="KVI04055">
        <property type="protein sequence ID" value="KVI04055"/>
        <property type="gene ID" value="Ccrd_017632"/>
    </dbReference>
    <dbReference type="OMA" id="EVYIIYT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000005">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI04055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="384" mass="42129" checksum="425A294E64CA7793" modified="2016-04-13" version="1" fragment="single">PLKSGPISFTRKVGVGPSDHINVGCECDYQRYFKAFELQQIDQKSPKLTLLFRNTKPVTPMAMAALRREGRRFVPLVSSPRPINAIQSTLAPAEEQVGLGVRSISTQIVRNRMKSVKNIQKITKAMKMVAASKLRAIQVRAENSRGLWQPFTALLGDTPSVSVKKNVIVTISSDKGLCGGINSTSVKISRALHKINSGPDAECKYVVLGEKAKAQLIRDSKKHIELTMTELQKNFLNYTQVSVIADDILKNVEYDALRIVFNKFQSVVSFLPTTATVLSPEVVERESEAGGKIGSLDSYEIEGGETKSEVLQNLSEFQFSCVMFNGVLENACSEQGARMSAMDSSSRNAGDMLDRLTLTYNRTRQASITTELTEIISGASALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7R1</accession>
    <name>A0A103Y7R1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_017624</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002312">
        <property type="protein sequence ID" value="KVI04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7R1"/>
    <dbReference type="Gramene" id="KVI04069">
        <property type="protein sequence ID" value="KVI04069"/>
        <property type="gene ID" value="Ccrd_017624"/>
    </dbReference>
    <dbReference type="OMA" id="WSVSELY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="11">
        <location>
            <begin position="215"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="12">
        <location>
            <begin position="468"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="595"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="922" mass="106583" checksum="AD4E5C4A63E04B16" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7S4</accession>
    <name>A0A103Y7S4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Barwin-like endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002310">
        <property type="protein sequence ID" value="KVI04091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7S4"/>
    <dbReference type="STRING" id="59895.A0A103Y7S4"/>
    <dbReference type="Gramene" id="KVI04091">
        <property type="protein sequence ID" value="KVI04091"/>
        <property type="gene ID" value="Ccrd_017595"/>
    </dbReference>
    <dbReference type="OMA" id="SHKLWIR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039923">
        <property type="entry name" value="Protodermal_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33210:SF24">
        <property type="entry name" value="POLLEN OLE E 1 ALLERGEN AND EXTENSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33210">
        <property type="entry name" value="PROTODERMAL FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119480" description="Barwin-like endoglucanase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29636" checksum="DAD1B2C4A4EF21DE" modified="2016-04-13" version="1">MGLGLVTTLLIVGAAIGGANGDAMVSGSVFCDQCKDGQVTLFDYPLTGYGQPTVIGEVTTNWLGGYVMRFEGAPDMGGCRAQVSGSGQGCGAVAGPSRGLNLVFQMFDTEIYTVDPLISQPAQPMSFCPRSSSPLPKPVTPALPPPAKLPPTPRPPQLPPLPRLPPTPSCYWRVLSPDLKVAVVFGPLAGRKYGTDLTLRGSMTGRADPYKTLLREATTALLNSYNSIEFPYHPLDVVQRLNYALIGGSTRQVLMTALRFLKANSGQPGNITCKFTTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7U6</accession>
    <name>A0A103Y7U6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002309">
        <property type="protein sequence ID" value="KVI04119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7U6"/>
    <dbReference type="STRING" id="59895.A0A103Y7U6"/>
    <dbReference type="Gramene" id="KVI04119">
        <property type="protein sequence ID" value="KVI04119"/>
        <property type="gene ID" value="Ccrd_017590"/>
    </dbReference>
    <dbReference type="OMA" id="RAMFPWG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11446">
        <property type="entry name" value="bHLH_AtILR3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044579">
        <property type="entry name" value="bHLH11/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057075">
        <property type="entry name" value="bHLH_IRO3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47001:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47001">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23177">
        <property type="entry name" value="bHLH_IRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="292" mass="32514" checksum="C1EF6A55CDFB062B" modified="2016-04-13" version="1">MDNLSPPNQFNSESRPGSEPKDRKLQKADREKQRRDRLNEQFTELGKTLDPDRPKFDKATILGDTIQMLNDLTDQVSRLKSEYAMLTEESRELTQEKHDLREEKASLKSDIENLNLQYQQRLRAIYPWGHMDQSVVMHPPSYPYPVPMPMPPGSIPMHPTIQPYPFFGNQNPGVVSNPCSTFFQSIQYVSPVAQPSTRSHVSSRQGSRNKSSEQGESGSGKDVDSNDVATELELKTPGSTGDQGSLAQSKSKKLHRKENSVSDESSPSGCSSSRTIQASSSNSVVGGKNCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y814</accession>
    <name>A0A103Y814_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chloramphenicol acetyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_017470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002294">
        <property type="protein sequence ID" value="KVI04229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y814"/>
    <dbReference type="STRING" id="59895.A0A103Y814"/>
    <dbReference type="Gramene" id="KVI04229">
        <property type="protein sequence ID" value="KVI04229"/>
        <property type="gene ID" value="Ccrd_017470"/>
    </dbReference>
    <dbReference type="OMA" id="CKVELTH"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051504">
        <property type="entry name" value="Plant_metabolite_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31625">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="453" mass="50362" checksum="3F73B95D10D7FCE2" modified="2016-04-13" version="1">MASLPILTILEQSHVSPPPATVADASLPLAFFDILWLPFSPVHHIFFYELPAVSKTHFTETIIPNLKQSLSITLQHFFPFSGNLIVFSTPTLKPEIRYVNGDSVAFTVAESTLDFNDLTGNHPRDCGKFYHLIPLLPEATKESDHVKIPVFSIQVTFFPNSGISVGMTNHHSLGDASTRFCFLKAWTSIARTGSDESFLANGTLPFFGRVVNYPKIDELYLKRVEVETTFNKDYQPPRLSGPTDKVRATFILTRTVINGLKKWVSTQLPTLPYVSSLTVLCAYTWSCVAKSRNDELEIFSIAVDCRARIDPPIPAAYFGNCVVLCLSIAKTDVLTGNEGFLNAAKLLGENLHKMLTDKTGIVKDKWPFDSLLSQGIPTTIMGVTGTTKLKFYDMDYGWGKPTKYETISIDYNDFISLSTCKESNEDLELGVCLSATEMEAFVPIFSKGLEAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8F8</accession>
    <name>A0A103Y8F8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_017250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002061">
        <property type="protein sequence ID" value="KVI04434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8F8"/>
    <dbReference type="STRING" id="59895.A0A103Y8F8"/>
    <dbReference type="Gramene" id="KVI04434">
        <property type="protein sequence ID" value="KVI04434"/>
        <property type="gene ID" value="Ccrd_017250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000060">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053106">
        <property type="entry name" value="Plant_Male-Germline_Reg_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI04434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="67" mass="8016" checksum="56B3B19B7281096F" modified="2016-04-13" version="1">MEQLIPIEIKKGPWKIEEDELLIKHVEEYGPRDWDLPLSKGHLQRTGKSCRLRWLNSYQPNLKKGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBN0</accession>
    <name>A0A103YBN0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_015535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001849">
        <property type="protein sequence ID" value="KVI06115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBN0"/>
    <dbReference type="STRING" id="59895.A0A103YBN0"/>
    <dbReference type="Gramene" id="KVI06115">
        <property type="protein sequence ID" value="KVI06115"/>
        <property type="gene ID" value="Ccrd_015535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="YDG" evidence="9">
        <location>
            <begin position="224"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI06115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="319" mass="35534" checksum="1E96C7C21446070A" modified="2016-04-13" version="1">MASRSPPCLYKHHSYSSQRTSIFQSISSLKHQLLPLRRLASMAPVKQMPCNIDGVCMMCKTKPSEAAKVLCITCLTSWHVTCITIPPQTVAAVLLWECSVCTNRDVIGAPADVPTPCGHNFCLKCFGKWMSQGKPNCPKCRYVIPSAMARNPRVNVLMENAIREAKVSVSVQPQGSSSQTDRPDAAFTTERARKAGLANASSGRILVTVPRDHFGPITAENDPKRNQGVLVGEYWMSRMEVRQWGVHFAHISGISGQSKTGAQSVVLSGVYKDDEDHGEAYKNKHSVYSPREGYRYDGIYRIERCWRKVGVQRYAWRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCG1</accession>
    <name>A0A103YCG1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retrieval of early ER protein Rer1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_015104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001799">
        <property type="protein sequence ID" value="KVI06550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCG1"/>
    <dbReference type="Gramene" id="KVI06550">
        <property type="protein sequence ID" value="KVI06550"/>
        <property type="gene ID" value="Ccrd_015104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="310" mass="35453" checksum="D50A3B6939435227" modified="2016-04-13" version="1">MEGVGGDAASPMAPLAKWKNEFSRAFQFYLDKSTPLPFHRWLGTLAVAAIYVLRVYYLEGFYIISYGLGIYILNLLIGFLSPKVDPELEALDGASLPTKESDEFRPFIRRLPEFKFCGIPFLFSRIRKLMKGLVPFSFKIRRAKNSTWHQRYAITKAFMVAFLMTFFSLFDVPVFWPILLCYWIVLFALTMKRQIMHMIKYKYVPFNIGKQVGFLFEKLIRARGETTSGGSQSSKVVSLLSRRALGSMARRHTERPALGPTSAPSPTPTPTPTPISETHVPITFELEVSRDTRISSVWLNQLTTRLKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDP4</accession>
    <name>A0A103YDP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001511">
        <property type="protein sequence ID" value="KVI07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDP4"/>
    <dbReference type="STRING" id="59895.A0A103YDP4"/>
    <dbReference type="Gramene" id="KVI07192">
        <property type="protein sequence ID" value="KVI07192"/>
        <property type="gene ID" value="Ccrd_014447"/>
    </dbReference>
    <dbReference type="OMA" id="HKMDKQV"/>
    <dbReference type="OrthoDB" id="2018987at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021864">
        <property type="entry name" value="DUF3475"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007700">
        <property type="entry name" value="DUF668"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31371">
        <property type="entry name" value="BNAC09G50660D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31371:SF14">
        <property type="entry name" value="SIMILARITY TO UNKNOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11961">
        <property type="entry name" value="DUF3475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05003">
        <property type="entry name" value="DUF668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3475" evidence="2">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF668" evidence="1">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53887" checksum="6A8000D30F6C3EC6" modified="2016-04-13" version="1">MALETWLIKVKKTISHSFDSARVTPPTKTCSVIKRSRIGVLAFEIAGIMPKLTHMWRFLSDQTMARLHNESICLEGVRKIVSNEDAFLLGLACAEMVENLRVLAKSVSRLSKRCQDSSLRCFGTAFDGFANMGHDPYGWILSLKEMEGKTKKMERYVAATATLYREMDELTVIQNNLKKSLLCSNSKKDHQHQDVSSQKILHLQQKLLWQQQEVKYVKEKSLWNTSFDSVTSLLATSIFTILSRIKLVFSITHGYPTSLPHSLSASATVYPSDQTSNSWDIVPGPLIKSSTHQHNNNISHGFFETNSKMLKPSSGTLGTAALALHYANLIIVMEKMIRSPQLVGLDARDDLYSMLPNSIRSSLRGRLKGIGFTASDPVLAGEWREALGKILGWLSPLAHNMIKWQNERSFEHQNLVPKTNVLLLQTLFFANQEKTEAAITELLVGLNYIWRFEREMNAKALFNCTNFNSIKNPQHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEG7</accession>
    <name>A0A103YEG7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001502">
        <property type="protein sequence ID" value="KVI07582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEG7"/>
    <dbReference type="STRING" id="59895.A0A103YEG7"/>
    <dbReference type="Gramene" id="KVI07582">
        <property type="protein sequence ID" value="KVI07582"/>
        <property type="gene ID" value="Ccrd_014059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027854">
        <property type="entry name" value="STMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33528">
        <property type="entry name" value="OS07G0239500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33528:SF14">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15054">
        <property type="entry name" value="DUF4535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119643" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="81" mass="9306" checksum="50ABB34C7C5D41E8" modified="2016-04-13" version="1">MGIIKSSFSFMLGAVCGVYIAQNYNVPNIHKLADYAVLMAKQMEESRDSTLHPRSVEFYIWKISRLLICLALELVVRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEL5</accession>
    <name>A0A103YEL5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001498">
        <property type="protein sequence ID" value="KVI07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEL5"/>
    <dbReference type="Gramene" id="KVI07656">
        <property type="protein sequence ID" value="KVI07656"/>
        <property type="gene ID" value="Ccrd_013962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045344">
        <property type="entry name" value="C-JID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF573">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20160">
        <property type="entry name" value="C-JID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C-JID" evidence="3">
        <location>
            <begin position="290"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="47575" checksum="89C5F4E3107D5013" modified="2016-04-13" version="1" fragment="single">MANGKTLVDSGILRLQPYFDRICKIWPKDDSKFIDMISKHIFNELNDGPLHAGENLVGGTESIEGLALDVSSSEVNICGKTFTKLYNLRLLQLYIGSWNKLRDINGKIRQSKFGTETKVKATSGGLEYLSSELRLFCWHGYPFQNLPSTFYPESLVVLDLSYSGRREEIQTKSWGLILWPSFSSRKMHHPPSAVFHSLSSLRFLRNVDVSHCNLTEASVDGIDCLSMLETLNLSGNDFTSLPTLSQLFRLETLGLVGCKNIQAMPELPPNIQLIEAQDCTSLRGLPEKSTIIPGWFSNQSTGDCIKVELPPAWCYENFKGIALCLVFSPRNLDGRKSSYGSIVYGFKIFDGTPIGKESPIPDSIFQYENIGIKSDQILLCYHQSEPNWKKAKNFISVCFQVYGADCVVKMCGARLVCEEDEQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEY0</accession>
    <name>A0A103YEY0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_013783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001481">
        <property type="protein sequence ID" value="KVI07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEY0"/>
    <dbReference type="Gramene" id="KVI07852">
        <property type="protein sequence ID" value="KVI07852"/>
        <property type="gene ID" value="Ccrd_013783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10710" checksum="8563EE3F58002D17" modified="2016-04-13" version="1" fragment="single">IDQAEQALSISPGSTNWYTPVVEEVVKHIIESVYPSLDVAESEYQKYVETAGFEVVRNLKESTIVCSCNHIGRHGYLCRHVFKVLLNVGVEFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFS3</accession>
    <name>A0A103YFS3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_013364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001158">
        <property type="protein sequence ID" value="KVI08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFS3"/>
    <dbReference type="STRING" id="59895.A0A103YFS3"/>
    <dbReference type="Gramene" id="KVI08264">
        <property type="protein sequence ID" value="KVI08264"/>
        <property type="gene ID" value="Ccrd_013364"/>
    </dbReference>
    <dbReference type="OMA" id="VHGLSWH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15488" checksum="FF3C8D4BFD5FA203" modified="2016-04-13" version="1">MRQSISQTTVSNGNAKGPSMFNAFRCMSSKLFVGGLSYQTDDHSLKEAFSGFGDVVEGNLYIIFIYGIQVCRMSRVITDRESGRSRGFGFVNYTSDDSAKEAMTAMDGQELNGRSIRVSLATERAPRTGGFSGGGGGYGNDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHH1</accession>
    <name>A0A103YHH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001069">
        <property type="protein sequence ID" value="KVI09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHH1"/>
    <dbReference type="STRING" id="59895.A0A103YHH1"/>
    <dbReference type="Gramene" id="KVI09185">
        <property type="protein sequence ID" value="KVI09185"/>
        <property type="gene ID" value="Ccrd_012428"/>
    </dbReference>
    <dbReference type="OMA" id="IEADSIM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF122">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="193" mass="22956" checksum="6DB9CEE7D5B0A483" modified="2016-04-13" version="1" fragment="single">KYVPWTFLHLLVKPSQHFFSYNYREKLCCTNIEADSIMDPSETLRYETTGIRPEYLRDALPLRQVQRKIQDFLCNGEPIWKIRPRGGKARILVGHGLDHDLKCLELEYPVVKISYDIQIGIQDPYDDCVATMRLYRRMRFQAHRNENYPLATDPQNKNNFASWRQSELERMSPDELLAISRSDYYCWCLDNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ21</accession>
    <name>A0A103YJ21_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase, subunit 1, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001033">
        <property type="protein sequence ID" value="KVI09970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ21"/>
    <dbReference type="Gramene" id="KVI09970">
        <property type="protein sequence ID" value="KVI09970"/>
        <property type="gene ID" value="Ccrd_011634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI09970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="39344" checksum="B66D1E4D3C5021E6" modified="2016-04-13" version="1">MKLQYPQDYLHYWTSREISSNQTCNKLKRDLACDNLSSIIKCLRRNSSHDNERLYRRSLYQAFQLVTLLDTPFDLPEAEAESVIGYNVEYVWDAILNSSRYFMAPKNFGNTFSLQDAKDKTEKLGASRKGRVDNEEGNVPLSLLDDKSSLVRFLRLKRDLGKGPIKPQELSSKVFKDLRWQNDLGNSLDNLMYERSKNLAYKPTITYVEMCDTIRKPSNLTWKLGTIKIIESKVESLEVRKVEKGGVRSAKIDHHHPDLELQSVDLCSSSCNLPNRSPVTRNQGQKYNYRKQEPQQSLGQSIAQQSYHNSQSCSILRALLVWTSRLTLVLSMLSSGSPNSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKE7</accession>
    <name>A0A103YKE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S5 domain 2-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000998">
        <property type="protein sequence ID" value="KVI10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKE7"/>
    <dbReference type="STRING" id="59895.A0A103YKE7"/>
    <dbReference type="Gramene" id="KVI10790">
        <property type="protein sequence ID" value="KVI10790"/>
        <property type="gene ID" value="Ccrd_010795"/>
    </dbReference>
    <dbReference type="OMA" id="CKRGCGM"/>
    <dbReference type="OrthoDB" id="186964at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="16383" checksum="FB9DD2D772652348" modified="2016-04-13" version="1">MAAAPPNSVQCFGRKKTAVAVTHCKAGRGLIKINGVPIELVQPEILRYKAFEPILLLGRHKFAGVDMRIRVKGGGHTSQIYAIRQSIAKALVAYYQKFVDEEQKKEIKDILVRYDRTLLVADPRRCEPKKFGGRGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKI1</accession>
    <name>A0A103YKI1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_010764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the chloroplastic Clp protease core complex which consist of at least 16 proteins: CLPP4 (3 copies), CLPP5 (3 copies), CLPR4 (2 copies), ClpP1 (1 copy), CLPP6 (1 copy), CLPR2 (1 copy), CLPT1 (1 copy), CLPT2 (1 copy) and 3 copies of CLPP3 and/or CLPR1 and/or CLPR3. The core complex is organized in two heptameric rings, one containing CLPP3,4,5,6 in a 1:2:3:1 ratio and the other CLPP1 and CLPR1,2,3,4 in a 3:1:1:1:1 ratio.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000994">
        <property type="protein sequence ID" value="KVI10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKI1"/>
    <dbReference type="STRING" id="59895.A0A103YKI1"/>
    <dbReference type="Gramene" id="KVI10821">
        <property type="protein sequence ID" value="KVI10821"/>
        <property type="gene ID" value="Ccrd_010764"/>
    </dbReference>
    <dbReference type="OMA" id="RYSMSVS"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009840">
        <property type="term" value="C:chloroplastic endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000020">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF55">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT-RELATED PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00062827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="394" mass="43250" checksum="82120084069CE822" modified="2016-04-13" version="1">MATSLLLSPLSAPTVDNNRDSSSSTTLFLKSSFLHNTTHFICATPRKDATVRGRCFRSPVTAAAGDKSLDHIPKQFREGNLQDGLMDNFKNVPQHLYGLSPSQMDMFMTEDNPVSRQAESVTEETISSSHNYLNNGGMWSMSGMNDSGPAKYSMSVSMYRGGGRPGGRPRSAPPDLPSLLLDARICYLGMPIVPAVTELLVAQFMWLDYDNPAKPIYLYINSSGTQNDEMETIGSETEAYAIADIMAYCKSEVYTVNCGMAFGQAAMLLALGTKGYRAMQPNSSTKLYLPKVNRSSGAAIDMWIKAKELDTNTDYFLELLEKGIGKSKEEIHKDIQRPKYFQAQEAIDYGIADKIISSRDHAFEKRNYDDILAQSKAARRGAGGGAQAAPSGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKU1</accession>
    <name>A0A103YKU1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000971">
        <property type="protein sequence ID" value="KVI10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKU1"/>
    <dbReference type="Gramene" id="KVI10969">
        <property type="protein sequence ID" value="KVI10969"/>
        <property type="gene ID" value="Ccrd_010633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="47" mass="5033" checksum="201EB98617939064" modified="2016-04-13" version="1">MLTCEGIVDTRQQQHGVGFGPNGARSPKKLPLDPMILTSSSLFFIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLK7</accession>
    <name>A0A103YLK7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_010233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000289">
        <property type="protein sequence ID" value="KVI11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YLK7"/>
    <dbReference type="STRING" id="59895.A0A103YLK7"/>
    <dbReference type="Gramene" id="KVI11359">
        <property type="protein sequence ID" value="KVI11359"/>
        <property type="gene ID" value="Ccrd_010233"/>
    </dbReference>
    <dbReference type="OMA" id="WKKYPLR"/>
    <dbReference type="OrthoDB" id="674745at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46442">
        <property type="entry name" value="DIRIGENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46442:SF16">
        <property type="entry name" value="DIRIGENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008191669" description="Dirigent protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="184" mass="20910" checksum="5EAE488D5670C307" modified="2016-04-13" version="1">MKASATFLLFFCHLLVVSLANSGMKRQYHPCRHLVFYFHDVVYNGQNDANATSAIVGAPQWGNLTILADKFHFGNVVVFDDPITLDNNFHSVPVGRAQGMYLYDTKYTWTAWLGFSFVFNSTQHKGTINFIGVDPLLVKTKDILVVGGTGDFFMHRGIATINTDSFEGEVYFRLRVDIKFYECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YLV1</accession>
    <name>A0A103YLV1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000112">
        <property type="protein sequence ID" value="KVI11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YLV1"/>
    <dbReference type="Gramene" id="KVI11494">
        <property type="protein sequence ID" value="KVI11494"/>
        <property type="gene ID" value="Ccrd_010093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="536" mass="61850" checksum="2CAD0FE923F192DA" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMZ8</accession>
    <name>A0A103YMZ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-protein beta WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_009457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000012">
        <property type="protein sequence ID" value="KVI12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMZ8"/>
    <dbReference type="STRING" id="59895.A0A103YMZ8"/>
    <dbReference type="Gramene" id="KVI12096">
        <property type="protein sequence ID" value="KVI12096"/>
        <property type="gene ID" value="Ccrd_009457"/>
    </dbReference>
    <dbReference type="OMA" id="VQKFKGY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF48">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="878" mass="97179" checksum="439EA3E642717008" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSG8</accession>
    <name>A0A118JSG8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005306">
        <property type="protein sequence ID" value="KVH89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSG8"/>
    <dbReference type="STRING" id="59895.A0A118JSG8"/>
    <dbReference type="Gramene" id="KVH89154">
        <property type="protein sequence ID" value="KVH89154"/>
        <property type="gene ID" value="Ccrd_008848"/>
    </dbReference>
    <dbReference type="OMA" id="EPETFTC"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000558">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g39710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF22">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="550"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="754"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="906" mass="102512" checksum="474FFA1D9A29547F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU30</accession>
    <name>A0A118JU30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Development/cell death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004903">
        <property type="protein sequence ID" value="KVH91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU30"/>
    <dbReference type="Gramene" id="KVH91809">
        <property type="protein sequence ID" value="KVH91809"/>
        <property type="gene ID" value="Ccrd_006182"/>
    </dbReference>
    <dbReference type="OMA" id="IDEDHQI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034:SF43">
        <property type="entry name" value="B2 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="186"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="319" mass="36290" checksum="27567E8FD7F2E1A7" modified="2016-04-13" version="1">MENNNQSSFWQFSDQLRVQSNNLNLSLNDSIWSTSYVSKRPEKERRNFDIRVGGDFINSATVNGNSSGGSNSDFNGFNFDWKIGSSNQNQVGDFGINGGFNKGIYSKPSLNFGVNNGNFEKNGFKKDGKFGIGKNGEDDHQIFGGKHGKNKKNSNNSNNNEKDNSKNSVDKRFKTLPPSESLPRNETVGGYIFVCNNDTMQENLKRQLFGLPPRYRDSVRQITPGLPLFLYNYSTHQLHGVFEAASFGGTNIDPSAWEDKKNPGESRFPAQVRVMTRKVAEPLEEDSFRPILHHYDGPKRSHFWTYSKRTRTEMRCRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVU9</accession>
    <name>A0A118JVU9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_004324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004706">
        <property type="protein sequence ID" value="KVH93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVU9"/>
    <dbReference type="STRING" id="59895.A0A118JVU9"/>
    <dbReference type="Gramene" id="KVH93624">
        <property type="protein sequence ID" value="KVH93624"/>
        <property type="gene ID" value="Ccrd_004324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="99" mass="11010" checksum="C02973ECEE82601F" modified="2016-04-13" version="1">MVHRTLVIIVFPRSTNKIIYTQIEYRKPIAPISLKGDESALIKNSFVCDDYERPKVSYNKLCNEIQVISLKGISNMDGGGGVGSCKAEICEKIVNTCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWC4</accession>
    <name>A0A118JWC4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho termination factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_002990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004491">
        <property type="protein sequence ID" value="KVH94946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWC4"/>
    <dbReference type="Gramene" id="KVH94946">
        <property type="protein sequence ID" value="KVH94946"/>
        <property type="gene ID" value="Ccrd_002990"/>
    </dbReference>
    <dbReference type="OMA" id="MTPRCNS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho termination factor-like N-terminal" evidence="3">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH94946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="528" mass="59205" checksum="76CE88FBC86D471C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWS4</accession>
    <name>A0A118JWS4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_003368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004549">
        <property type="protein sequence ID" value="KVH94555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH94555">
        <property type="protein sequence ID" value="KVH94555"/>
        <property type="gene ID" value="Ccrd_003368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH94555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="84" mass="10065" checksum="53FF247A5166A4B4" modified="2016-04-13" version="1">MQYAQRPTGLDKYLISLWSLVGSWNLYESKWVGYELAQKRHTTFTKTSFHIKYDSCXFRFFKFVGGVDSYRDQYCSQLFLSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXF4</accession>
    <name>A0A118JXF4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_001728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LEKV01004349">
        <property type="protein sequence ID" value="KVH96177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXF4"/>
    <dbReference type="STRING" id="59895.A0A118JXF4"/>
    <dbReference type="Gramene" id="KVH96177">
        <property type="protein sequence ID" value="KVH96177"/>
        <property type="gene ID" value="Ccrd_001728"/>
    </dbReference>
    <dbReference type="OMA" id="GRDIIWT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000119">
        <property type="entry name" value="probable pectin methyltransferase QUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1139">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH96177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="418" mass="46924" checksum="44214A5CDB112992" modified="2016-04-13" version="1">MRTPLFNKLYVFSGTRPPRNWLLLCLVSLFVLIALLGSSSSGAFDSVTTSLKPEVYTNYRRLKEQAASDYFELKSYSSGNSNSKEIWLCGKEREHYVPCYNVSANLLAGFKDGEEFDRHCEVSQDQPYCLVRPPRDYKTPLSWPVGRDVIWNANVKITKDQFLSSGSMTKRLMLLEENQISFHSDDGFVKDHSRQIAEMIGLGSDAEFWQAGVRTVLDIGCGFGSFGAHLLSLKLMAVCVAAYELTGSQVQLSLERGLPAIIGNFISRKLPFPSLSYDMVHCAQCGVLWDKKDGLFLIEADRILKPGGYFVLHGTSLSTKKGSMSSPIEEFTRNICWKLIAQQEETFIWQKTIEAQCYSSSKQGAIPPCREGYADLQSYYQPLESCIAGTASKRWVPIQNRSSSSQINPAELEIYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZ52</accession>
    <name>A0A118JZ52_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_022822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01003641">
        <property type="protein sequence ID" value="KVH98907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZ52"/>
    <dbReference type="STRING" id="59895.A0A118JZ52"/>
    <dbReference type="Gramene" id="KVH98907">
        <property type="protein sequence ID" value="KVH98907"/>
        <property type="gene ID" value="Ccrd_022822"/>
    </dbReference>
    <dbReference type="OMA" id="QDGNIEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF82">
        <property type="entry name" value="DIAMINE OXIDASE [COPPER-CONTAINING] 1, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="8">
        <location>
            <begin position="177"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="7">
        <location>
            <begin position="302"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="7">
        <location>
            <begin position="445"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="7">
        <location>
            <begin position="505"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH98907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="669" mass="74041" checksum="703E20499B0183BB" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ8</accession>
    <name>A0A118JZZ8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_021109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003364">
        <property type="protein sequence ID" value="KVI00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ8"/>
    <dbReference type="STRING" id="59895.A0A118JZZ8"/>
    <dbReference type="Gramene" id="KVI00630">
        <property type="protein sequence ID" value="KVI00630"/>
        <property type="gene ID" value="Ccrd_021109"/>
    </dbReference>
    <dbReference type="OMA" id="HVQWVEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="89" mass="10117" checksum="78EB4937681CDBF3" modified="2016-04-13" version="1">MDQFPGHVQWVENLDALLNNAHRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2H2</accession>
    <name>A0A118K2H2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002191">
        <property type="protein sequence ID" value="KVI04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2H2"/>
    <dbReference type="STRING" id="59895.A0A118K2H2"/>
    <dbReference type="Gramene" id="KVI04378">
        <property type="protein sequence ID" value="KVI04378"/>
        <property type="gene ID" value="Ccrd_017306"/>
    </dbReference>
    <dbReference type="OMA" id="RFKPNNY"/>
    <dbReference type="OrthoDB" id="531455at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36742">
        <property type="entry name" value="MYOSIN-G HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36742:SF1">
        <property type="entry name" value="MYOSIN-G HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19512" checksum="85B3AAF5F85EF115" modified="2016-04-13" version="1">MAFMNYTISRVCIHPKYSLLVPHKTKNFNFISSTTTVAALSEKGTDGSIGENDSRNASAAASPSARTRLDLLEQLTSTSPSGYESDGNYAELTIREKLAQLVGERDDDFSIRLGKKLKIPKLLTVSQKRNIKRQAYLNEVSRRNDTNFFAIIGAFVLLPPLIILGVAIATGYVQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2X8</accession>
    <name>A0A118K2X8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_016568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001890">
        <property type="protein sequence ID" value="KVI05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2X8"/>
    <dbReference type="STRING" id="59895.A0A118K2X8"/>
    <dbReference type="Gramene" id="KVI05072">
        <property type="protein sequence ID" value="KVI05072"/>
        <property type="gene ID" value="Ccrd_016568"/>
    </dbReference>
    <dbReference type="OMA" id="GPERMQI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="362" mass="41098" checksum="139788FC3D7C387D" modified="2016-04-13" version="1">MSLSCFRLHGFPTFRCISHRLITLSHFHFRVRGFSRTSMNQAEIGAMVNGSKCCSSKVVINDPKLLHHKKTSIRLAGPSKFQVIADFDNTLTKFWVDGCRGQSSHGLLQQENPEYNAKRDELFNYYHPIEYDPQIPIDEKTKLMEEWWGKSHGLLIEGGLTYDAIRSSVAGAVIAFREGVVELFEFLEARERYPGSYIFSRSSRYHRGGKLKPGPVHVHVLRQKLHRTFKNVKIVSNRMKFDQNGNLVSFTGKLIHSLNKNEHALDMAASLHDHLGEVDDQIIDSASVKKRTNVLLLGDHMGDLRMSDGLNYETRISVGFLNHNIENSLDSYREGFDIVYLDDAPMSGVVKLVSELFSPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K324</accession>
    <name>A0A118K324_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor, K-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001880">
        <property type="protein sequence ID" value="KVI05280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K324"/>
    <dbReference type="STRING" id="59895.A0A118K324"/>
    <dbReference type="Gramene" id="KVI05280">
        <property type="protein sequence ID" value="KVI05280"/>
        <property type="gene ID" value="Ccrd_016389"/>
    </dbReference>
    <dbReference type="OMA" id="HERYNYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51297">
        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI05280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="134" mass="15835" checksum="75431727F5C4B3B5" modified="2016-04-13" version="1" fragment="single">MESILERYERYSYTERQLVAADAAPRSWTLEYNKLKSRAELLQRNHRHYMGEDIESLSLKEIQNLEQQLDTGLKNIRSRKNQLLHESISELQKKIKEKEKEKTITQNVPWEQHNYVDTDATFLMPPPPPALNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K512</accession>
    <name>A0A118K512_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transport inhibitor response 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001136">
        <property type="protein sequence ID" value="KVI08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K512"/>
    <dbReference type="STRING" id="59895.A0A118K512"/>
    <dbReference type="Gramene" id="KVI08358">
        <property type="protein sequence ID" value="KVI08358"/>
        <property type="gene ID" value="Ccrd_013278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041101">
        <property type="entry name" value="Transp_inhibit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18791">
        <property type="entry name" value="Transp_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transport inhibitor response 1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="114" mass="13013" checksum="E4DBE32F3918E7E8" modified="2016-04-13" version="1">MLVRLCEQFPFLKSLTIKERLHAAMFDLIPEDWGGSVTSWVREIMSSLNGLKAITFRCMIFHDSDNDLLARTHGQELRVLKIDGCFGFSMDGLLQTEKLCNNLKINVVSSTMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K525</accession>
    <name>A0A118K525_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock factor (HSF)-type, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001136">
        <property type="protein sequence ID" value="KVI08357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K525"/>
    <dbReference type="STRING" id="59895.A0A118K525"/>
    <dbReference type="Gramene" id="KVI08357">
        <property type="protein sequence ID" value="KVI08357"/>
        <property type="gene ID" value="Ccrd_013279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF377">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR A-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="59" mass="7213" checksum="B016907D905F51FE" modified="2016-04-13" version="1">MEVDLDNTFSSEDSHSWSSSRHQNNFFVWNPYEFARLLLPTFFKHNFSSFMRWLNAYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5A2</accession>
    <name>A0A118K5A2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001090">
        <property type="protein sequence ID" value="KVI08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118K5A2"/>
    <dbReference type="Gramene" id="KVI08775">
        <property type="protein sequence ID" value="KVI08775"/>
        <property type="gene ID" value="Ccrd_012849"/>
    </dbReference>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000294">
        <property type="entry name" value="Transformation/transcription domain associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2757"/>
            <end position="3246"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3549"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3815"/>
            <end position="3851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1621"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2095"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3267"/>
            <end position="3327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2102"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2154"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3298"/>
            <end position="3307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="3851" mass="433269" checksum="A93D7C9060EB27E1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5N6</accession>
    <name>A0A118K5N6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein ENHANCED DISEASE RESISTANCE 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5N6"/>
    <dbReference type="STRING" id="59895.A0A118K5N6"/>
    <dbReference type="Gramene" id="KVI09330">
        <property type="protein sequence ID" value="KVI09330"/>
        <property type="gene ID" value="Ccrd_012278"/>
    </dbReference>
    <dbReference type="OMA" id="KGPWILR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF114">
        <property type="entry name" value="PLECKSTRIN DOMAIN, START DOMAIN, PROTEIN ENHANCED DISEASE RESISTANCE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="4">
        <location>
            <begin position="168"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="84050" checksum="31A8AD467A2FDE80" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K5Z2</accession>
    <name>A0A118K5Z2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_011738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001038">
        <property type="protein sequence ID" value="KVI09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K5Z2"/>
    <dbReference type="STRING" id="59895.A0A118K5Z2"/>
    <dbReference type="Gramene" id="KVI09888">
        <property type="protein sequence ID" value="KVI09888"/>
        <property type="gene ID" value="Ccrd_011738"/>
    </dbReference>
    <dbReference type="OMA" id="CGRCKHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045218">
        <property type="entry name" value="DA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022087">
        <property type="entry name" value="DA1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209:SF7">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12315">
        <property type="entry name" value="DA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="130"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="436" mass="49162" checksum="63D47BF27C4D59D2" modified="2016-04-13" version="1">MSSSGNVNHLSQPCIYERKSWFMRWLSKLFKGGSNRGQVGSTHRPPQFIGDESMVLRAPVRSLDNRARTDKEKEEIDRAIALSLAEGLKKPNGYGWRPNNEADLAKTVQDDHHPSYPPYVPREYPPVGYRLCGGCNRDIGYGNYLGCMGTFFHPECFCCRACRYPIKEHEIPTNGAGLIEYRCHPFWSQKYCPAHEHDNTARCCSCERLESVNARYVSLGDGRSLCLECMESAIMDTGDCQPLYHTIRDYYEGMNMRLDQQIPMLLVERQALNEAIILRRPKFGGHAMIGMRTQPQKLTRRCEVTAILVLYGLPRLLTGAILAHELMHGWLRLKGYRNLNPEVEEGICQVLSYMWLESEIMPGSTSAAPSTSSSSVSKKGGKSRVENKLGEFFMHQIAHDASPAYGGGFRAANAAVNTYGLRRTLDHIRLTGNFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K6Y1</accession>
    <name>A0A118K6Y1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_010203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000222">
        <property type="protein sequence ID" value="KVI11387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K6Y1"/>
    <dbReference type="STRING" id="59895.A0A118K6Y1"/>
    <dbReference type="Gramene" id="KVI11387">
        <property type="protein sequence ID" value="KVI11387"/>
        <property type="gene ID" value="Ccrd_010203"/>
    </dbReference>
    <dbReference type="OMA" id="HAKQINI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22269">
        <property type="entry name" value="DPBB_EG45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47480">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47480:SF1">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="1">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI11387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="146" mass="15722" checksum="93216275C0BD8757" modified="2016-04-13" version="1">MMLNSNSNSKLQYLLQWISISLTSTLFMVVCCEVGTASMYNPPYTPSACYGNDASQFPSSNLFAAAGEGIWDNGAACGRQYLVRCISAVIPRTCIPGQTIQVKIIDRAKTSASRPTSMGTTMVLSDTAFGTIANQISSINIEFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K781</accession>
    <name>A0A118K781_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_009737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000034">
        <property type="protein sequence ID" value="KVI11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K781"/>
    <dbReference type="STRING" id="59895.A0A118K781"/>
    <dbReference type="Gramene" id="KVI11850">
        <property type="protein sequence ID" value="KVI11850"/>
        <property type="gene ID" value="Ccrd_009737"/>
    </dbReference>
    <dbReference type="OMA" id="YPPHGAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF119">
        <property type="entry name" value="PUMILIO HOMOLOG 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="456"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="525"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="722"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="795" mass="88096" checksum="35C37FD8B8ABFBC7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAH4</accession>
    <name>A0A124SAH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Folate receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_025234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006122">
        <property type="protein sequence ID" value="KVH87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAH4"/>
    <dbReference type="STRING" id="59895.A0A124SAH4"/>
    <dbReference type="Gramene" id="KVH87506">
        <property type="protein sequence ID" value="KVH87506"/>
        <property type="gene ID" value="Ccrd_025234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053305">
        <property type="entry name" value="Folate-binding_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390:SF1">
        <property type="entry name" value="FOLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390">
        <property type="entry name" value="OS02G0592500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="290"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="525" mass="59114" checksum="6EC543068E70291C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB11</accession>
    <name>A0A124SB11_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_008838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sterol desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005303">
        <property type="protein sequence ID" value="KVH89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB11"/>
    <dbReference type="STRING" id="59895.A0A124SB11"/>
    <dbReference type="Gramene" id="KVH89182">
        <property type="protein sequence ID" value="KVH89182"/>
        <property type="gene ID" value="Ccrd_008838"/>
    </dbReference>
    <dbReference type="OMA" id="QLYRWIH"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="287" mass="33788" checksum="E56DDE09F59739CD" modified="2016-04-13" version="1">MLAFECVEEIEVSLGRKVTSAEAFWLNYSANKSDYFLYCHNLIFLIIFYSLLPLPYVILQLIIRSSKNTHKFKIQPNITYSFTHMFDCYTKVVKLFLLTVGPLQLISFPIIQFVEIRTSLPLPSKREMFLQIVVYFIVEDYANYWLHRLLHTTWAYEKIHRVHHEYSAPMSFAASYAHWAEVIILGFASFLGPLLVPCHMITMWLWMIVRHAEAIETHSGYDLPWSPTRLIPFYGGAEYHDYHHYVGEKAQSNFASVFTYCDYIYGTDKGYRYAKKHRKGVRTKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB75</accession>
    <name>A0A124SB75_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chlorophyll a/b binding protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005144">
        <property type="protein sequence ID" value="KVH89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB75"/>
    <dbReference type="STRING" id="59895.A0A124SB75"/>
    <dbReference type="Gramene" id="KVH89757">
        <property type="protein sequence ID" value="KVH89757"/>
        <property type="gene ID" value="Ccrd_008248"/>
    </dbReference>
    <dbReference type="OMA" id="MSSMALY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="261" mass="29556" checksum="2FB6D42EDF3504C1" modified="2016-04-13" version="1" fragment="single">KLLCTIYFCVQLKLHPLFRPFLQIHLLPLSPSRFRPFSSELSSMSSMALYSSTPHFPSLSPYSKTHLPIHSFLSLNPKRDLLFVSVRAIENGSGFAIVENEKKDSEPEEDPLGNGGPTAASLEDAAVKFEDPKWVSGTWDLKQFQNGGATDWDAVIDAVFDTSIIPWWAWMKRFHLPEAELLNGRAAMIGFFMAYFVDSLTGVGLVDQTGNFLCKTLLFVAVSGVLLIRKNEDLDNLKKLVEETTYYDKQWQATWQEQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBF8</accession>
    <name>A0A124SBF8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_007449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBF8"/>
    <dbReference type="Gramene" id="KVH90532">
        <property type="protein sequence ID" value="KVH90532"/>
        <property type="gene ID" value="Ccrd_007449"/>
    </dbReference>
    <dbReference type="OMA" id="TRVWFSM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF15">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4, VACUOLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH90532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="537" mass="56825" checksum="872568362D1B8702" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBS6</accession>
    <name>A0A124SBS6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Phloem protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_006410</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004924">
        <property type="protein sequence ID" value="KVH91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SBS6"/>
    <dbReference type="Gramene" id="KVH91567">
        <property type="protein sequence ID" value="KVH91567"/>
        <property type="gene ID" value="Ccrd_006410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF338">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE, NON-RECEPTOR JAK_TYK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="641" mass="73944" checksum="30E6004F8B8C0930" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SC29</accession>
    <name>A0A124SC29_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase, TIM beta/alpha-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_005449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004815">
        <property type="protein sequence ID" value="KVH92500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SC29"/>
    <dbReference type="STRING" id="59895.A0A124SC29"/>
    <dbReference type="Gramene" id="KVH92500">
        <property type="protein sequence ID" value="KVH92500"/>
        <property type="gene ID" value="Ccrd_005449"/>
    </dbReference>
    <dbReference type="OMA" id="PLMAFWL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26178">
        <property type="entry name" value="PI-PLC_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176135" evidence="1">
        <location>
            <begin position="29"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH92500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="387" mass="42149" checksum="DCDB7FABACE498D1" modified="2016-04-13" version="1">MKKSLLGGDANQYLLLFVSATFFLTSSACSNGECQVLESCSAATDCAAGLYCGNCPQLGKTQPFCIRGQAVVPTSINGVRGLMLDMYDFENDIWLCHSFHGQCLNITAFVIIFSPVQPAINTLREVEAFLSLNPTEIVTIIIEDYVHTPRGLTKLFVDAGLDKYLFPVSKMPRKGEDWPTVTDMAQQNHRLLVFTSDSSKEGTEGIAYQWRYMVENDPGDPGVEQGSCPNRKESKPLTSKTTSLFLQNYFPTMPVQAEACKEHSAPLMDLVGTCYKAAGNVMPNFLAVNFYMRSDGGGVFDALDRMNGPSLCGCVSVTACQTGASFGACRNNAVSNSTSPRGPSGSFSGTVQLTGSASRIDLTSEDKRDFIEAWLLFFNEQVGEIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCM3</accession>
    <name>A0A124SCM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Electron transport accessory protein-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_003680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCM3"/>
    <dbReference type="STRING" id="59895.A0A124SCM3"/>
    <dbReference type="Gramene" id="KVH94255">
        <property type="protein sequence ID" value="KVH94255"/>
        <property type="gene ID" value="Ccrd_003680"/>
    </dbReference>
    <dbReference type="OMA" id="YFRIRTN"/>
    <dbReference type="OrthoDB" id="2161449at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.50:FF:000001">
        <property type="entry name" value="Photosystem I reaction center subunit IV, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003375">
        <property type="entry name" value="PSI_PsaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34549:SF3">
        <property type="entry name" value="PHOTOSYSTEM I PSAE, REACTION CENTRE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34549">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT IV A, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02427">
        <property type="entry name" value="PSI_PsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="Electron transport accessory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH94255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14356" checksum="BF07028A57A27192" modified="2016-04-13" version="1">MASCSMASAATGFMVTPNLTSNTTTVRCTMLMFSSKNTRSSRLVVKAADEAAPPTAAAPLAAETAPKPPPIGPKRGTKVRILRKESYWFKGVGSVVTVDQDPKTRYPVVVRFNKVNYANVSTNNYALDEIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD41</accession>
    <name>A0A124SD41_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_002198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD41"/>
    <dbReference type="STRING" id="59895.A0A124SD41"/>
    <dbReference type="Gramene" id="KVH95752">
        <property type="protein sequence ID" value="KVH95752"/>
        <property type="gene ID" value="Ccrd_002198"/>
    </dbReference>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH95752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="317" mass="34980" checksum="C3E1A10FCCAD61A9" modified="2016-04-13" version="1">MEEPGQLKRAFIDATAGSISGAISRTVQLEPTTSFALLSKNVYGTSKYTGMFQASKDIFREEGLSGFWRGNVPALLMVMPYTAIQFMVLHKVKTFASGSSKSEDHIHLSPYLSFMSGALAGCAATVGSYPFDLIRTILASQGEPKIYPNMRSAFVEIMNTRGFRGLYAGLSPTLVEIIPYAGLQFGTYDTFKRWTMAWNGRWSSGATHPEEPITSFQLFLCGLAAGSCAKAVCHPLDVVKKRFQIEGLQRHPKYGARVEHRAYRNMYDALKRIMQQEGWAGLYKGIVPSIVKAAPAGAVTFVAYEYTSDWVESVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF06</accession>
    <name>A0A124SF06_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_019942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002684">
        <property type="protein sequence ID" value="KVI01771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF06"/>
    <dbReference type="Gramene" id="KVI01771">
        <property type="protein sequence ID" value="KVI01771"/>
        <property type="gene ID" value="Ccrd_019942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="39" mass="4393" checksum="46E35F703D2CC77D" modified="2016-04-13" version="1">MHLHLGAWTSLSLQTNCPSPTKGRGCREMEKGSRRCCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF42</accession>
    <name>A0A124SF42_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF42"/>
    <dbReference type="Gramene" id="KVI02056">
        <property type="protein sequence ID" value="KVI02056"/>
        <property type="gene ID" value="Ccrd_019641"/>
    </dbReference>
    <dbReference type="OMA" id="WVSKRHF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="777"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="812"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="988" mass="112856" checksum="65C307A19AD8954B" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFM8</accession>
    <name>A0A124SFM8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002332">
        <property type="protein sequence ID" value="KVI03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFM8"/>
    <dbReference type="STRING" id="59895.A0A124SFM8"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36032">
        <property type="entry name" value="PHOSPHOPANTOTHENATE--CYSTEINE LIGASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36032:SF1">
        <property type="entry name" value="PHOSPHOPANTOTHENATE--CYSTEINE LIGASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="193" mass="21028" checksum="0A2CEFAF831A2E90" modified="2016-04-13" version="1" fragment="single">LQSLDKKHFQKRYDTPDPDRQNVFQQSNAASISIRDQNRSLGRRKSGGADELTSADGLERANIYVNDGDKNQVAALRNVPILDRPDPQRLIALEGCCNSEAYQLLNNRWAAAMNSYENPSTDIAERPMIPATSGVGPSGHQIDFLSELRLAMHNSNASSDKTSGRGGGSSRTIVARAITMARPTVISHLLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFP4</accession>
    <name>A0A124SFP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_017807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01002323">
        <property type="protein sequence ID" value="KVI03888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFP4"/>
    <dbReference type="STRING" id="59895.A0A124SFP4"/>
    <dbReference type="Gramene" id="KVI03888">
        <property type="protein sequence ID" value="KVI03888"/>
        <property type="gene ID" value="Ccrd_017807"/>
    </dbReference>
    <dbReference type="OMA" id="KSIDHFF"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="8">
        <location>
            <begin position="42"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="9">
        <location>
            <begin position="344"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="467" mass="52319" checksum="CAE7A44C02D27AAE" modified="2016-04-13" version="1">MLAFTLKNLSGYNMHSNFNPEAKFLLTSLLVSLILIAFYMTKRTSRRVYLLDFACYKAPDSQKVAKDFMVEKAKHSGYFSEEKVDFMRKVLEKSGLGDSTYLAEVYLKQVADPCMKESRREIEMSVFGSIDMLLAKTGVKCEEIGILVVNCCIYNTMPSLSSMIVNRYKLKESIASYNLVGMGCSAGLIAIGLAEQLLQVHHDTYALVMSTESITENCYIGDDRSKFLINCLFRVGGAAILLSNRPSDHQNCKYELLHTVHTNEASSDRSYNCIIQEEDAAGQRGITVTKHLFTAASTVVESNVTKLGMQILPVSEKLKYLTNTIARKLRPTANIQPYKPNYAKSIENFLPHVGGKPVLDELQRNLGFSNAVMESSRMTLYRFGNTSSSSIWYELAYAEAKGRVKKGSRVWQIAFGSGFKCSSVVWHAVRTVDYDELNPWTVEIDGFPVDVDCDDHGPMSIFFEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5N3</accession>
    <name>A0A103D5N3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01011544">
        <property type="protein sequence ID" value="KVD98176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5N3"/>
    <dbReference type="STRING" id="59895.A0A103D5N3"/>
    <dbReference type="Gramene" id="KVD98176">
        <property type="protein sequence ID" value="KVD98176"/>
        <property type="gene ID" value="Ccrd_024126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007114162" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVD98176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="75" mass="7873" checksum="C534A6F1FECBE66F" modified="2016-04-13" version="1" fragment="single">MASRLLLIGLVFVASCSLALASDPSPLQDFCVADPNSRVLVNGVVCKDPNLVKADDFLYRGLNLMGDTSMGVGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103M7X9</accession>
    <name>A0A103M7X9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008912">
        <property type="protein sequence ID" value="KVF89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103M7X9"/>
    <dbReference type="Gramene" id="KVF89346">
        <property type="protein sequence ID" value="KVF89346"/>
        <property type="gene ID" value="Ccrd_026636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVF89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="71" mass="7793" checksum="9CD1549EE3DC4992" modified="2016-04-13" version="1" fragment="single">MASGGQDLILALKETIRYDIDGQEDMKLIYGTIVVEESGNQEKDVKVGDVVRHKGGKPLLKQQSHSVILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103NU98</accession>
    <name>A0A103NU98_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008478">
        <property type="protein sequence ID" value="KVG19142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVG19142">
        <property type="protein sequence ID" value="KVG19142"/>
        <property type="gene ID" value="Ccrd_026534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG19142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="88" mass="9957" checksum="7A8D95CBE6B16DC3" modified="2016-04-13" version="1" fragment="single">MTKLHLQARTSGAPDGTRKMKRFTNIRCGGLAPTKASCIKNMLSCLFEKRGELCLEYLRDLSVDEIKMELSRFKGIGPXTIHFIILMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Q5M9</accession>
    <name>A0A103Q5M9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008157">
        <property type="protein sequence ID" value="KVG43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Q5M9"/>
    <dbReference type="STRING" id="59895.A0A103Q5M9"/>
    <dbReference type="Gramene" id="KVG43318">
        <property type="protein sequence ID" value="KVG43318"/>
        <property type="gene ID" value="Ccrd_026414"/>
    </dbReference>
    <dbReference type="OMA" id="KHQMIAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVG43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="91" mass="10132" checksum="5D6C47EC96FEA697" modified="2016-04-13" version="1">MDQIKHNYIQVDGLKLHVAEIGSQSAPPVLFFHGFPEISYTWRHQMIAVANAGYRAIAPDYRGYGLSDIPAEPEKTPHHVTVLNVSSSDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBN5</accession>
    <name>A0A103XBN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005871">
        <property type="protein sequence ID" value="KVH87748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBN5"/>
    <dbReference type="Gramene" id="KVH87748">
        <property type="protein sequence ID" value="KVH87748"/>
        <property type="gene ID" value="Ccrd_024966"/>
    </dbReference>
    <dbReference type="OMA" id="HVEMDVE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF2">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH87748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="316" mass="35286" checksum="3E3D11347F068A54" modified="2016-04-13" version="1">MIGWDDIYKVVIAMFPLYVALILGYGSVKWWHMFKPDHCDSINRLNCYFIMPFFTFEFTTCIDPYKFNYRFAVADAISKVIILFAISLWTKFSINGNYPWSITTFSLSTLNNTLIVGVPLMRAMYGSLGENLAIQSSILQFLFWIILLLLMYEFQSANKRLCLDVDRENDNISEEETMTGTKPSSLILMKIVGLKLAKNPNSYACILGLTWALVSNRAGSGVAMFCMGLFMALQDKIIECGVTLAVFGMLLRFVAAPATMAVGSLVAALPQAITAFTYAKEYDLHANVLSTAVIFGTILSIPVLVAYYVVLDVLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XDF9</accession>
    <name>A0A103XDF9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005358">
        <property type="protein sequence ID" value="KVH88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XDF9"/>
    <dbReference type="Gramene" id="KVH88641">
        <property type="protein sequence ID" value="KVH88641"/>
        <property type="gene ID" value="Ccrd_026242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="12492" checksum="209AC41DCF58916D" modified="2016-04-13" version="1">MAGAIGGKTGALMDWSVNTSYKSLKASDGTLTGGRWNPSRSKNSVCIWHYCCSIAVVLVINLATILLPPSLLPRLLVVSITSILERRCPIAYSYLSHGLDLLLAVYSRIIRISDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEG4</accession>
    <name>A0A103XEG4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4 14">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_008777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 14"/>
    <dbReference type="EMBL" id="LEKV01005286">
        <property type="protein sequence ID" value="KVH89237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEG4"/>
    <dbReference type="STRING" id="59895.A0A103XEG4"/>
    <dbReference type="Gramene" id="KVH89237">
        <property type="protein sequence ID" value="KVH89237"/>
        <property type="gene ID" value="Ccrd_008777"/>
    </dbReference>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="16">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH89237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="275" mass="28543" checksum="332BE0883F14F619" modified="2016-04-13" version="1">MGSAPIPSETYKLGFIGAGKMAESIARGVIKSGILPASRIKTAHKGSRRTTFESFGVGVVEHNNQVVENSDVVIFSVKPQVVKDAILQLRPILSEKKLLVSVVAGVKLKDLQEWAGHDRFIRVMPNTPAAVGEGASVMSLGAGATQEDGEIIAKLFGAVGKIWKADEKLFDAVTGLSGSGPAYIFLAIEALADGAVAAGLPRELALGLASQTVLGAASMASHAGKHPGQLKDDVTSPGGTTIAGVHELEKSGFRGILMNAVVAAAKRSRELSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEQ9</accession>
    <name>A0A103XEQ9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005242">
        <property type="protein sequence ID" value="KVH89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEQ9"/>
    <dbReference type="STRING" id="59895.A0A103XEQ9"/>
    <dbReference type="Gramene" id="KVH89328">
        <property type="protein sequence ID" value="KVH89328"/>
        <property type="gene ID" value="Ccrd_008680"/>
    </dbReference>
    <dbReference type="OMA" id="WILKCVE"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047714">
        <property type="term" value="F:galactolipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31403:SF8">
        <property type="entry name" value="PHOSPHOLIPASE A(1) DAD1, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31403">
        <property type="entry name" value="PHOSPHOLIPASE A1-IBETA2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="427" mass="47497" checksum="B678CBB84683C2BA" modified="2016-04-13" version="1">MAKPCNLPRSATHLTEIPNCTSTSMNYRPRSQLSVKSSWNSDSGQTRVASRVAKLGQKWREYQGIKNWEGLLDPLDDGLRHEILRYGDFVEAAYRSFEFDTSSADYATCKYSKNSMLERCGLGGSGYKVTKNLHATCGVQLPGWINRVPSCTSVNSTWIGYVAVCNDEEEIARLGRRDVVIAFRGTATCLEWIENLRATLTSIPNDVAPESKRAMVQKGFLSMYTSATTTCPSLRDMVREEISSVIDKYGDEPLSVTITGHSLGAALATLTAYDITSTFERSPMVTVVSFGGPRVGNRNFRSQLENSGTRILRIVNSTDVITKVPGFLADDSNDMTNRGIPVAGLPEWLQKRVAESQWFRYADIGKELRLSSDASPYLTKSDFATCHDLKTYLHLVDGFVSSTCPFRTKAKRLLAGTKHEKQQIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XES2</accession>
    <name>A0A103XES2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005211">
        <property type="protein sequence ID" value="KVH89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XES2"/>
    <dbReference type="Gramene" id="KVH89419">
        <property type="protein sequence ID" value="KVH89419"/>
        <property type="gene ID" value="Ccrd_008586"/>
    </dbReference>
    <dbReference type="OMA" id="VEGFFML"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="151"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="34768" checksum="5752AAB137BFA90D" modified="2016-04-13" version="1">MTSSQPLLQSHGSVQELAKQLKLAVPDRYVQEHQEPTTFVFNSSIPVIDMNDLIKILETDMDQLKNLQSVCHEWGIFQLVNHGVDKLLVENMKKEMVEFFKIPIEQKMKYKLKGGEYEGYGQTILHAQDQKVDWADLAIDKPEMLETFEDGMQSVRMTYYPPCPQPDLVIGLTPHSDAAGITILLQVNDVEGLQVKKDGVWLPVSFLPDAFVVNVGDILEIMSNGAYNSIEHRVTVNGTKERISLAMFFNPKLEAEVGPAKSFLKNTGKPPLYRTLVMEQYLKEFFSRKLNGKTFLEKMKIKNGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF30</accession>
    <name>A0A103XF30_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005208">
        <property type="protein sequence ID" value="KVH89474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XF30"/>
    <dbReference type="Gramene" id="KVH89474">
        <property type="protein sequence ID" value="KVH89474"/>
        <property type="gene ID" value="Ccrd_008520"/>
    </dbReference>
    <dbReference type="OMA" id="THRFTSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="419" mass="45947" checksum="FFABF70ADE2ADA65" modified="2016-04-13" version="1">MMHQEAMDQRFSSCRGVSFEIQPHKDPFAIDAPRASRRSWVPWGSSNKIAPTSGAIISRSNSRASSHFCDLETDDEDDEDDVLINIEEGHELDDKYELPLPVSIPEVLPQAPSKKILSKPTKPKGSRLSVILLDQGLFTVYKRLFMVCLALNITGLALAATGHFPYARNHATLFSIGNLLALTLYVGSRLVKEQEFWFTLVTTILIIIPWVTVRRVAVKVSAPSGHASIIKFAGGVKPGILGRISPSPMSEWHAFGIISDGKEEHMMLAGAVGDFTKSLVSNPPSHLWVRQVHFAGLPYLVNMYNRVLVVATGSGICVFLSFLLQQGPADVCLLWVAKGIEQNFGKEIKEWVSRHPKEKVIVHDTAVMGRPNVSEMSVAAARNFGAEVVIVTSNPEGSRDVVNACKSKGIPAFGPIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFK9</accession>
    <name>A0A103XFK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Brevis radix-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_008150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005133">
        <property type="protein sequence ID" value="KVH89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFK9"/>
    <dbReference type="STRING" id="59895.A0A103XFK9"/>
    <dbReference type="Gramene" id="KVH89848">
        <property type="protein sequence ID" value="KVH89848"/>
        <property type="gene ID" value="Ccrd_008150"/>
    </dbReference>
    <dbReference type="OMA" id="FNCQALD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013591">
        <property type="entry name" value="Brevis_radix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044532">
        <property type="entry name" value="BRX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058:SF26">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08381">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51514">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="323" mass="37390" checksum="CAF1D6CF47220FC3" modified="2016-04-13" version="1">MVIGNRKLETQWIEFKKEKMLTCITCSKQQMKDMALKASGSSKGKPPTGPSSFKRAHTDYDSMLSKGYMHSGGSSSSTAPWDFNANGGYEPPRQSGHLVLDDDDDPTEWMAQVEPGVQITFVSLPNGGNDLKRIRFNREMFDKWQAQRWWGENYDRIMELYNVQRFNCQALDTPSRSEDGVTSLPPFSIMIPEQVLDLDKEIYYRDSTYSRFGSVRDSPMMNPIRNNYYKPPEQINHYNASSMDASRTTTSSRDETSVSISNASDMDSEWIEEDEPGVYITIRQLVDGTRELRRVRFSREKFGEVHAKQWWEQNRERIQSQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFU1</accession>
    <name>A0A103XFU1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase C13, legumain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_008084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005125">
        <property type="protein sequence ID" value="KVH89918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFU1"/>
    <dbReference type="STRING" id="59895.A0A103XFU1"/>
    <dbReference type="Gramene" id="KVH89918">
        <property type="protein sequence ID" value="KVH89918"/>
        <property type="gene ID" value="Ccrd_008084"/>
    </dbReference>
    <dbReference type="OMA" id="MQACPTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000005">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF47">
        <property type="entry name" value="LEGUMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118764" evidence="9">
        <location>
            <begin position="24"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="393"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH89918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="506" mass="56454" checksum="2144A58A28017AA3" modified="2016-04-13" version="1">MTIKMIRYVIVLLALSIITVVHGRELADDLIRLPSEKHDFFDAGKDDSVGTRWAILLAGSNGYWNYRHQADVCHAFQILKNGGVKEENIVVFMYDDIAYNRENPRQGVIINSPDGDDVYQGVPKIKETRSESFFTDVPHCLKQDYTGKDVNVDNFFAVLLGNKTAVKGGSGKVVNSGPNDRIFIYYTDHGGPGVLGMPTNPYLYADDLNAVLKQKHASGTYKSLVFYLEACEAGSIFEGLLPQGLNIYATTASGPDESSWGTYCPGEYPSPPLEYDTCLGDLYSVAWMEDCDVHNLRTETIKQQYKLVKERTSSDNSYYGSHVMQYGDLPLSKDNLYLYMGTNPANDNFTFVDEDSLQRPAKAVNQRDADLLHFWHKYRKAPEGSETKTEAQKKFAEAMSHRMHIDSSIQLIGKLLFGLEKGPQVLNAVRPAGRPLVDDWARLKTLVRTFETHCGSLSQYGMKHMRSIANLCNEGITNEQMAAASSQACTTFPSNPWSSISNGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGN9</accession>
    <name>A0A103XGN9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01005104">
        <property type="protein sequence ID" value="KVH90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGN9"/>
    <dbReference type="STRING" id="59895.A0A103XGN9"/>
    <dbReference type="Gramene" id="KVH90374">
        <property type="protein sequence ID" value="KVH90374"/>
        <property type="gene ID" value="Ccrd_007625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="244"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="560" mass="61939" checksum="4BA62E18A77F951C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH56</accession>
    <name>A0A103XH56_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps4 oligomerization, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_007304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH56"/>
    <dbReference type="STRING" id="59895.A0A103XH56"/>
    <dbReference type="Gramene" id="KVH90675">
        <property type="protein sequence ID" value="KVH90675"/>
        <property type="gene ID" value="Ccrd_007304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF159">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH90675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="25639" checksum="349FEE890E7DDDCE" modified="2016-04-13" version="1">MYSNFKEQAIQYVKQAVHEDNAKAFPFIHERFGILHFRTHLKIREAITLKFTEYLRSPEEIGALIDDAGAGPAANGGDTATKTKDGEGDGEDPEQAKLRTGLNSAIAIRRRFDKLIYIPLPDLKARLHMFKLQRDAPNNKNESDFESLACKTEGFSGSDIAVKDALFESVCKTQDAMFFVKTNEDLWVPCGPKQPGAVRSQELAEKRPTVSKSDLEVHETFTKEFGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XH67</accession>
    <name>A0A103XH67_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">4-hydroxyphenylpyruvic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_007270</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Cofactor biosynthesis; prenylquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01005097">
        <property type="protein sequence ID" value="KVH90690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XH67"/>
    <dbReference type="STRING" id="59895.A0A103XH67"/>
    <dbReference type="Gramene" id="KVH90690">
        <property type="protein sequence ID" value="KVH90690"/>
        <property type="gene ID" value="Ccrd_007270"/>
    </dbReference>
    <dbReference type="OMA" id="EYQRGGC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000013">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000025">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF15">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="19">
        <location>
            <begin position="47"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="19">
        <location>
            <begin position="226"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVH90690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="47446" checksum="283C2EC350C65EF7" modified="2016-04-13" version="1" fragment="single">MGKEDELVNGSGVAGKQDRSPALDFKPVNYNNFNRTNPMSDLFSVRRFHHVEFWCSDATNTSRRFSWALGMPIVAKSDISTGNTTHASYLLRSSQLLFLITAPYSATISTVDTNTASIPTFSHAACRAFIAAHGLAVRSVAIEVDDAELAYSISVYNGAKSSSPPITLGEQENAGVLAEVQVYNDAVLRYISFTKPTIDITSTFLPGFEPIESSSSFPGQDYGLRRLDHAFGNVPELASAVNYIKSFTGFHKFAEFRAEDVGTIESGLNSMALACNNETVILGFCEPIYGTRRRSQIQTYLEHNEGPGFQHLALESEDIFWTLREMKQRSGFGGLEFMPPPPPTYYRNLKKRIGDALSDDQMKACEELGILVDRTDEDTLLQIFTKPLGDRPTIFIEIIQRKGCMIENNKQKPGCGGFGEGNISELFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHH3</accession>
    <name>A0A103XHH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005091">
        <property type="protein sequence ID" value="KVH90808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHH3"/>
    <dbReference type="STRING" id="59895.A0A103XHH3"/>
    <dbReference type="Gramene" id="KVH90808">
        <property type="protein sequence ID" value="KVH90808"/>
        <property type="gene ID" value="Ccrd_007179"/>
    </dbReference>
    <dbReference type="OMA" id="PPYEAFC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.310:FF:000013">
        <property type="entry name" value="Outer envelope protein 80 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000006">
        <property type="entry name" value="Outer envelope protein 80, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.310:FF:000014">
        <property type="entry name" value="Outer envelope protein 80, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF32">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 80, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="1" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="313"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="730" mass="79555" checksum="DB6E4B10776D9530" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIN2</accession>
    <name>A0A103XIN2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ataxin-2, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004949">
        <property type="protein sequence ID" value="KVH91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIN2"/>
    <dbReference type="STRING" id="59895.A0A103XIN2"/>
    <dbReference type="Gramene" id="KVH91475">
        <property type="protein sequence ID" value="KVH91475"/>
        <property type="gene ID" value="Ccrd_006502"/>
    </dbReference>
    <dbReference type="OMA" id="APNFDNT"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12459">
        <property type="entry name" value="RRM1_CID8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12460">
        <property type="entry name" value="RRM2_CID8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000665">
        <property type="entry name" value="Polyadenylate-binding protein-interacting protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000530">
        <property type="entry name" value="Polyadenylate-binding protein-interacting protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034823">
        <property type="entry name" value="CID8-like_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034825">
        <property type="entry name" value="CID8-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF77">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 11-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="273"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="40030" checksum="A3ED81CBE4FBFFD8" modified="2016-04-13" version="1">MAVVENGGSIESNDVDQSESSVLISRSNDNHQSFHQEKNIMTNVNGTSINGNGVASHQQHQMVVNGVDRHDHEEEDFKKEMRDLEEMLSKLNPMAEEFVPPSLSNNSYNRTLVQSPSVAGHFGYAAANDFLLQTNHTAFFNVNGISTGRKKGNFSSGKRRMNSRTNMAQREDAIKRTVHVSDIDQQVTEEQLAALFINCGQVVDCRVCGDPNSVLRFAFIEFTDEEGAKNALSLAGTMLGFYPVRVLPSKTAIAPVNPTFLPRSEDEREMCARTIYCTNIDKKVTQADVKLFFESLCGEVYRLRLLGDYHHSSRIAFVEFVMAESAIAALNCSGAVLGSLPIRVSPSKTPVRPRTPRPTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIP1</accession>
    <name>A0A103XIP1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005038">
        <property type="protein sequence ID" value="KVH91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIP1"/>
    <dbReference type="STRING" id="59895.A0A103XIP1"/>
    <dbReference type="Gramene" id="KVH91382">
        <property type="protein sequence ID" value="KVH91382"/>
        <property type="gene ID" value="Ccrd_006596"/>
    </dbReference>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000055">
        <property type="entry name" value="pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="7">
        <location>
            <begin position="209"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35594" checksum="408401116A657F01" modified="2016-04-13" version="1">MRLWRSTIITHLTTPLAVFSSKHTSKFAMTTSSEIGGSFSAPRLVAKKLLAKSQSEGDGAVVRRSIGRPELKSLDPFLLLDEFSVSPPAGFPDHPHRGFETVTYMLEGAFTHQDFAGHKGTIRAGDVQWMTAGRGIIHSEMPVGTGAQKGLQLWINLSSKDKMVEPNYQELLNEDIQRAERDGVKVTIVAGESMGVKSPVYTRTPTMFLDFTIAPGAQMHQPIPESWNSFVYVLHGVGVFGSMDSSPISAHHAVVLSPGDGLSIWNHGSKPLRFVLIGGQPINEPVVQYGPFVMNTQAEIDMTLQDYHYCKNGFERAKLWRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJL4</accession>
    <name>A0A103XJL4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_006112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The PPC domain mediates interactions between AHL proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004901">
        <property type="protein sequence ID" value="KVH91868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJL4"/>
    <dbReference type="STRING" id="59895.A0A103XJL4"/>
    <dbReference type="Gramene" id="KVH91868">
        <property type="protein sequence ID" value="KVH91868"/>
        <property type="gene ID" value="Ccrd_006112"/>
    </dbReference>
    <dbReference type="OMA" id="SHYYLQR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039605">
        <property type="entry name" value="AHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500:SF103">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="7">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH91868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="305" mass="30444" checksum="6396650C09249933" modified="2016-04-13" version="1">MDGREGMPSFYLNRGFRGSGSNAGSGNQVGGFHLPPPGFKTQSNPNLAPHGHGNMGVGVAPPMGLPFHMEHNPSPNFPHGINMGGGGGGGNGGGGNDDVGGGGGGGGGNDDVSGGGGVSIPNPGSGSESVVKKKRGRPRKYAPDGSHMALGLTPVSPGAGMGTAASHDRSSPPPQKKRGRPRGSGRKQRLANVGEWMHNSAGSAFTPHIIHISVGEGRFEILCLSGSYLLAESGNPRNRTGSLSISACNADGQVIGGAIGGKLIASSLVQVVVCSFVYGGGDNSKAKTATEPVSGDEKSPGVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK13</accession>
    <name>A0A103XK13_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004835">
        <property type="protein sequence ID" value="KVH92206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK13"/>
    <dbReference type="STRING" id="59895.A0A103XK13"/>
    <dbReference type="Gramene" id="KVH92206">
        <property type="protein sequence ID" value="KVH92206"/>
        <property type="gene ID" value="Ccrd_005761"/>
    </dbReference>
    <dbReference type="OMA" id="SKCFVAY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="713" mass="79048" checksum="368532DA699FB545" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKG6</accession>
    <name>A0A103XKG6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KOW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_005539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004818">
        <property type="protein sequence ID" value="KVH92421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKG6"/>
    <dbReference type="STRING" id="59895.A0A103XKG6"/>
    <dbReference type="Gramene" id="KVH92421">
        <property type="protein sequence ID" value="KVH92421"/>
        <property type="gene ID" value="Ccrd_005539"/>
    </dbReference>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH92421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16892" checksum="1A766F8987BD779C" modified="2016-04-13" version="1">MKYNPRVTSSRRKCRKAHFSAPSSVRRVLMSAPLSTELRSKYNVRSVPVRKDDEVQVVRGTYKGREGKVVQVYRRKWVIHVERITREKVNGQTVNVGINPSKVVVTKLKLDKDRKSLLDRKAKGRAADKSKGKFTVDDVAAGASLQEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XKU5</accession>
    <name>A0A103XKU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinesin, motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_005552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004819">
        <property type="protein sequence ID" value="KVH92414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XKU5"/>
    <dbReference type="STRING" id="59895.A0A103XKU5"/>
    <dbReference type="Gramene" id="KVH92414">
        <property type="protein sequence ID" value="KVH92414"/>
        <property type="gene ID" value="Ccrd_005552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH92414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="423" mass="48338" checksum="6F9F1E32BF8DF79B" modified="2016-04-13" version="1">MIATISPADNQYHHTVNTLKYADRAKEIKTHIQKNIGTVDTHVSDYQRMIDSLQTEVSQLKTQLAEKESQLNKPTERPVDDELSWLNILSQETSENVQERINLQKALFELEETNLRNRTELQHLDDGIAKQQVIENDGTVVQALVLRRQLVLDNIRDNDETGVIYQKEIEANEKRRCQLQEMIDEAISNNANKTYLRILSQYRLLGMTNTELQFEMAMRDQVIHNQRETQRNLWNLVMGLGLDEKQLLKLAAKQGIVIEDWAMTPQLGLSDGTASWKMGHERSPHIPLCSASRQSCPNPSSTSPQNQAGPRPFSEGYGDTYCREEHHSSYYFMSHNSPSTYMSLTRSSENWVGHMSSSLYPSPDMHPPGLGDSYLKMRGTGSSNGDGRASTSPHQKVWIPFTCQIYLEGQWRCIEENVKAIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XM78</accession>
    <name>A0A103XM78_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHCH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_004562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004774">
        <property type="protein sequence ID" value="KVH93396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XM78"/>
    <dbReference type="STRING" id="59895.A0A103XM78"/>
    <dbReference type="Gramene" id="KVH93396">
        <property type="protein sequence ID" value="KVH93396"/>
        <property type="gene ID" value="Ccrd_004562"/>
    </dbReference>
    <dbReference type="OMA" id="HYGTEIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH93396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="138" mass="13801" checksum="E5D803B391D576E2" modified="2016-04-13" version="1">MARRSSGGRSARAPARAPARNPSAPASRAPPPAPVQASSGGSMLGGIGSTIAQGLAFGTGSAVAHRAVDSIMGPRTIQHETVGAAAPDAATTNSVSDACGNHSKAFADCINSSGSDISKCQFYMDMLAECRRNSSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XPN7</accession>
    <name>A0A103XPN7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004550">
        <property type="protein sequence ID" value="KVH94535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XPN7"/>
    <dbReference type="STRING" id="59895.A0A103XPN7"/>
    <dbReference type="Gramene" id="KVH94535">
        <property type="protein sequence ID" value="KVH94535"/>
        <property type="gene ID" value="Ccrd_003389"/>
    </dbReference>
    <dbReference type="OMA" id="KMVISPV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669:SF12">
        <property type="entry name" value="EMB|CAB85507.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23733">
        <property type="entry name" value="GRXCR1-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="391" mass="42723" checksum="59EAACB44F27E8AD" modified="2016-04-13" version="1">MGCVSSKHIKKDLKKEMLLNGGGDFTHHVVSLTSSTYGALKLDKDQQPPPPAAPVTPTKQKNSPPRRSNQGPPEIINAWELMEDLEDEPQAPISIPAKKSPKLRRGFAEIDVKTPMKFLNQLGSSPKVSKRFSGKENKKVGSRKLDYSPKITIVKASTLPPNLRISKRGGSESPVESGLNSARRRNLGPLFDPDLIDPIGRKKFQEKEQIKKMISATPTIQKSRNSIESKSILETFENKFPSGGENAVVIYTTTLRGIRKTFEDCNTVRGIIESHNVRMIERDVSMDSGFKEEVRALLGKKQVTVPIVLVKGRLIGGSNEIMKLEEEGKLGILLDGIPTVAATGCKGCGGVRFVMCTVCNGSCKLIGGDGRRSIKCVDCNENGLVQCPICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ78</accession>
    <name>A0A103XQ78_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_003057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004511">
        <property type="protein sequence ID" value="KVH94878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ78"/>
    <dbReference type="STRING" id="59895.A0A103XQ78"/>
    <dbReference type="Gramene" id="KVH94878">
        <property type="protein sequence ID" value="KVH94878"/>
        <property type="gene ID" value="Ccrd_003057"/>
    </dbReference>
    <dbReference type="OMA" id="KAQFLRP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046510">
        <property type="term" value="F:UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046506">
        <property type="term" value="P:sulfolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000044">
        <property type="entry name" value="Sulfoquinovosyl transferase SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="274"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH94878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="450" mass="50620" checksum="E15FD25CB38EDAF7" modified="2016-04-13" version="1">MPTSLISLNPSISLPSSSASASSSSSSIVTSSRISCFYAFRQKPICFTPSKPRFFRYERRITTPIIVSSAKQVTIEELRKDDEEGPPSQVESEVTTKPRRIALFVEPSPFAYVSGYKNRFQNFIKYLREMGDEVMVITTHEGVPQEFHGAKLVGSRSPRIINEVKQFKPDIIHASSPGIMVFGALAIAKMLCVPIVMSYHTHVPVYIPRYTFSWLVKPMWLVLKFLHRAADLTLVPSAAIAKDLRQARVTAANKIRLWNKGVDSESFNPIFRSQEMRVRLTEDLEKLFVGMPAVFTGTLQGDELSQAYASGDVFVMPSESETLGLVVLEAMSSGLPVVAARAGGIPDIIPEEQEGKTGYLYTPGDLDDCLNKLVPLLHDAKLRENIGQAARVEMEKFDWRAATKMIRNQQYNAAIWFWRKKRAQLLKPVQWVSKIFFPIQRRQKLTAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRB1</accession>
    <name>A0A103XRB1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_002486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004388">
        <property type="protein sequence ID" value="KVH95446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRB1"/>
    <dbReference type="STRING" id="59895.A0A103XRB1"/>
    <dbReference type="Gramene" id="KVH95446">
        <property type="protein sequence ID" value="KVH95446"/>
        <property type="gene ID" value="Ccrd_002486"/>
    </dbReference>
    <dbReference type="OMA" id="WAQESNN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="9">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="10">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH95446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="231" mass="25309" checksum="695C0D6C5A163F51" modified="2016-04-13" version="1">MASFHHSYVFCIIVLFGSVLVRAVYSIPRAPIVYRPSPWTLAHATFYGDESASSTMGGACGYGNLMTNGYSTNTAALSSTIFRDGYACGQCYQIRCVESPWCSKGIATITATNLCPPNWSQDSNKGGWVPCVRKGGVRFSFQGNGYWLLVYVMNVGGAGDIRSMWVKGTKTAWISMSHNWGASYQAFATLRGQALSFRLTSYTTKQTITAYNVAPANWNLGLTYQANVNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRV0</accession>
    <name>A0A103XRV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-acyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_002185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="LEKV01004378">
        <property type="protein sequence ID" value="KVH95743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRV0"/>
    <dbReference type="Gramene" id="KVH95743">
        <property type="protein sequence ID" value="KVH95743"/>
        <property type="gene ID" value="Ccrd_002185"/>
    </dbReference>
    <dbReference type="OMA" id="KIMDAYH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF324">
        <property type="entry name" value="S-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="185"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH95743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="429" mass="49150" checksum="64213D46C6E83EEC" modified="2016-04-13" version="1" fragment="single">MNKTSCPSRGLSDKQNSNKNVNAPSLRLYQVWKGNNIFALGGRLIFGPDARSLYLTISLIVVPVILFCSLVSQTLVDNFPNNLGPLLVAIPAVFTVYVSCFFLYVMILCCKQQIDEKEQVTYYYILVLIFLVSARDPGIIPRNPPNPDLDDDWDACSMSTDWAASGRYLPPTKSVNVNGMVVRVKFCQTCMLYRPPRCSHCSVCNNCVDRFDHHCPWVGQCIGKRNYLYFFMFVSSTALLCLYVFAMCWVNIILIMNAKNCSLWEAFMKSPASGILISYTFTVSWFVGGLSVFHLYLVITNQTTYENFRYRYERRMNPYNHGCASNIKDVLFSKIPPSQHKFRSFVKPEWYSQYNSSRYFAYAFSGNYTKKSYDTDVSYEGSEFDLERCETHQTDHSGKWSNGPELHRLASKFIAENVTREKSKKNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVW5</accession>
    <name>A0A103XVW5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microtubule-associated protein, MAP65/Ase1/PRC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003817">
        <property type="protein sequence ID" value="KVH97853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVW5"/>
    <dbReference type="STRING" id="59895.A0A103XVW5"/>
    <dbReference type="Gramene" id="KVH97853">
        <property type="protein sequence ID" value="KVH97853"/>
        <property type="gene ID" value="Ccrd_000050"/>
    </dbReference>
    <dbReference type="OMA" id="TMDEYIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF3">
        <property type="entry name" value="65-KDA MICROTUBULE-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH97853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="491" mass="55743" checksum="760B3574A2E6EC83" modified="2016-04-13" version="1">MIWDEVGEDEFEREKVLVDLEHECLQIYRRKVDDANMSRARLHQELADSEAQFTHLILSLDDRSLPGRPEKLAGTLKEQLGAIAPALRKMQTRKAERMKQFRAVQLQIHKISAEIAGQSEYDDSLPEAVVNENDLSLKKLEEYQMKLQGLEADKSDRLERVKNYIIAIQNLSAMLGMDSSMIITKVHPSLNELSGLSKNMSDRILAKLNATVESLEAEKRSRIEKLHNLGNSLKNLWDLMDTPYIDRQLFSHILGSITSTNISAPGSLSITMIEQAEAEVERLDQLKASKMKELLVKKQTELEEICRRSHMEVPSLSKTDHIVNLINRAEDEASSRKMIMEKVEKWVLARDEERWLEEYTMDDKRYTVSRGAHKNLKRAERARAMVNKISGTFTGVDGGEKKITHSQVVVLHESVMLTRPTTGSRRQLDRSVDGGFKIRGSTGVQLVTNNVRSSYQNALKGSQGPKIFARARIDRHLREDQASGGSPFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWB1</accession>
    <name>A0A103XWB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA glycosylase/AP lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_023736</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003812">
        <property type="protein sequence ID" value="KVH98044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWB1"/>
    <dbReference type="STRING" id="59895.A0A103XWB1"/>
    <dbReference type="Gramene" id="KVH98044">
        <property type="protein sequence ID" value="KVH98044"/>
        <property type="gene ID" value="Ccrd_023736"/>
    </dbReference>
    <dbReference type="OMA" id="HARESTC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049332">
        <property type="entry name" value="Fpg-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="FPG_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21218">
        <property type="entry name" value="Fpg-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="13">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH98044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="444" mass="48970" checksum="D73A47A617B8A1A6" modified="2016-04-13" version="1">MPELPEVEAARRAIEENCIGKKIKRSVVADDAKVIDGVSPSDFEASLTGKTIVAAHRKGKNMWIQLDSPPFPSFQFGMAGAIYIKGVTVTKYKRSAVNDTDEWPSKYSKLFIELDNGLELSFTDKRRFAKVRLLKNPASVAPISELGPDALLEPLTEDELFKSLSKKKIGIKALILDQSFISGVGNWIADEVLYQARIHPLQSAASISKDSCAALHNSLKEVIRHSVEVDADCSRFPVIEKAVEVGADSSQFPSNWIFHSREKKPGKAFVDGKKIEFINAGGRTSAFVPELQKLSGEQAAKAAVKPQKRSSKKNKDEDDEPESEDEEIAKNAKPEGGKKTTQSRAKNPNTKRKSIENDDKSSDANDKKSATRKKSKGSSEVDEHQKGSKGHKKPPAKKKAQESEEDSDDDGEEEGEEEERVQVKGKKEVAKKVQTGRQTNKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWE1</accession>
    <name>A0A103XWE1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional coactivator Hfi1/Transcriptional adapter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_023692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003810">
        <property type="protein sequence ID" value="KVH98089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWE1"/>
    <dbReference type="Gramene" id="KVH98089">
        <property type="protein sequence ID" value="KVH98089"/>
        <property type="gene ID" value="Ccrd_023692"/>
    </dbReference>
    <dbReference type="OMA" id="MGMEDNV"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH98089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="412" mass="44988" checksum="4D75AE3043EBF17F" modified="2016-04-13" version="1">MQPPQQHSWINLAELKSQIIRKLGPERSKQYFDYLNRFLNLKLSKVEFDKLCLRTIGRDGIPLHNQLIHSILKNACTANDNPLRQAGNKKPSDGVYHQNGSISAVTQASNPLALPNGDTLSPSLRKARTGARERRGVDRRSALGPNGKTNYSSPSSSIPHSEDFSTPLENGNSSSPDTRRPVQHHQELNQQMENANENSSHHSAKLAASTSQSPDGLLAVHSKAESESLSRKDGKGVSGRISLHAPLGIPYCPVSIGGSRSAIPLASSSKCVGVSSTNSLLDTITLRARMDPIAATHDLQGVSVDCANALNNGLDAYLKGLIRSCSELNGARSGHVPLKNTPAHLRPLNGVRPGHHYQMQTSSWPLDTMQENEPKRTISLLEFRVAMELNPQQLGEDWPMLLEKICTHAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWK2</accession>
    <name>A0A103XWK2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histidine kinase-like ATPase, ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_023584</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MORC ATPase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWK2"/>
    <dbReference type="STRING" id="59895.A0A103XWK2"/>
    <dbReference type="Gramene" id="KVH98225">
        <property type="protein sequence ID" value="KVH98225"/>
        <property type="gene ID" value="Ccrd_023584"/>
    </dbReference>
    <dbReference type="OMA" id="LHIHPRF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF61">
        <property type="entry name" value="HISTIDINE KINASE_HSP90-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Morc S5" evidence="12">
        <location>
            <begin position="412"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Morc S5" evidence="12">
        <location>
            <begin position="464"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="603"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH98225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="664" mass="74326" checksum="2558E63DFEE6F784" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZ62</accession>
    <name>A0A103XZ62_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIGANTEA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_022186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003439">
        <property type="protein sequence ID" value="KVH99576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZ62"/>
    <dbReference type="STRING" id="59895.A0A103XZ62"/>
    <dbReference type="Gramene" id="KVH99576">
        <property type="protein sequence ID" value="KVH99576"/>
        <property type="gene ID" value="Ccrd_022186"/>
    </dbReference>
    <dbReference type="OMA" id="EYIGQFT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048586">
        <property type="term" value="P:regulation of long-day photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026211">
        <property type="entry name" value="GIGANTEA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36319">
        <property type="entry name" value="PROTEIN GIGANTEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36319:SF1">
        <property type="entry name" value="PROTEIN GIGANTEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02081">
        <property type="entry name" value="GIGANTEA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131750" checksum="400CD5B5DCEAF95B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZD6</accession>
    <name>A0A103XZD6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7870 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_022063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003419">
        <property type="protein sequence ID" value="KVH99696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZD6"/>
    <dbReference type="STRING" id="59895.A0A103XZD6"/>
    <dbReference type="Gramene" id="KVH99696">
        <property type="protein sequence ID" value="KVH99696"/>
        <property type="gene ID" value="Ccrd_022063"/>
    </dbReference>
    <dbReference type="OMA" id="GDHTMAN"/>
    <dbReference type="OrthoDB" id="1919622at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057192">
        <property type="entry name" value="DUF7870"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33597:SF12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33597">
        <property type="entry name" value="OS02G0760400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25276">
        <property type="entry name" value="DUF7870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7870" evidence="1">
        <location>
            <begin position="237"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH99696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="413" mass="48064" checksum="2B76EFF689F29423" modified="2016-04-13" version="1">MAAYVHRHLRSKFHDLVHLIKLLRVYGLRFRVRAFLMALFVVSSPWIGSTIRGEYNFVVFNQGDDHRVEFINDNSIELEVFLMLFQNLTNEGVLGMHDKGLIVNNDDEDEKLVDYYPSIDFISYVDLEHKHASHDYDFVFTHESVESVDKFLKLDGIMVVQKKGAIKDSESLQKPSNYETLFVKQLELPTTTEMITIIAMKKTRTVGDHDKNKNEVGSNTNIPHRRLMFEQKKAEAIKNIENVVLEPPRTISGKSSIYFKKTRYLPDLMDDSFLEEYPRRVFIDVNGDSTVWFTKNYPTKNKNFEIFKLETTIPETGTKEDVEDDVEGAFVETEITDWLRENVKKDEYVVMRGEAEVVEELIKSKAIGLVDELFLECKYQGIKCQKCRRPYWKCLALYGLLKDAGVAVHQWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZV5</accession>
    <name>A0A103XZV5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01003404">
        <property type="protein sequence ID" value="KVH99935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZV5"/>
    <dbReference type="Gramene" id="KVH99935">
        <property type="protein sequence ID" value="KVH99935"/>
        <property type="gene ID" value="Ccrd_021815"/>
    </dbReference>
    <dbReference type="OMA" id="THIAWIA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000047">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF182">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="514" mass="57131" checksum="15B07FF3FBF0556A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y040</accession>
    <name>A0A103Y040_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_021722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y040"/>
    <dbReference type="STRING" id="59895.A0A103Y040"/>
    <dbReference type="Gramene" id="KVI00052">
        <property type="protein sequence ID" value="KVI00052"/>
        <property type="gene ID" value="Ccrd_021722"/>
    </dbReference>
    <dbReference type="OMA" id="EWVAMKV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031:SF16">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="82"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="29899" checksum="CF1F66AA8983332C" modified="2016-04-13" version="1">MAHLYKSRLQNYAQKKNIAFPMYACEMQGPPHSRLFKARVTIDGVMYEGPEFCTTLKDAEHAAAKVAFTSLSPDGAKEDDCLYKSLLQELAQKKGLVLPVYATNRAGPPHMPSFASTVQIAGKCFVGQEARTKKQAEMNAAKVAYTDLTEGGPRVNNAAVFSDIQMVGTSSFGSSSAQMVVADKKEPTLISSTSKMGTTINDQASCSIAKEAEKAKGSGLNGKRSQQNQSSVTDLGAAKPVSTKIVIRPHVHGMTYEGPIEVADDEWVAMKVNVDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0Z7</accession>
    <name>A0A103Y0Z7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003385">
        <property type="protein sequence ID" value="KVI00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0Z7"/>
    <dbReference type="SMR" id="A0A103Y0Z7"/>
    <dbReference type="STRING" id="59895.A0A103Y0Z7"/>
    <dbReference type="Gramene" id="KVI00505">
        <property type="protein sequence ID" value="KVI00505"/>
        <property type="gene ID" value="Ccrd_021253"/>
    </dbReference>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12415" checksum="548B04E147361E28" modified="2016-04-13" version="1">MAKHHPDLIMCRKQPGIAIGRLCEKCDGKCVICDSYVRPCTLVRVCDECNYGSFQGRCVICGGVGISDAYYCKECTQQEKDRDGCPKIVNLGSAKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1F4</accession>
    <name>A0A103Y1F4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003261">
        <property type="protein sequence ID" value="KVI00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1F4"/>
    <dbReference type="STRING" id="59895.A0A103Y1F4"/>
    <dbReference type="Gramene" id="KVI00776">
        <property type="protein sequence ID" value="KVI00776"/>
        <property type="gene ID" value="Ccrd_020970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051861">
        <property type="entry name" value="NET_actin-binding_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258:SF14">
        <property type="entry name" value="GB|AAF19561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07765">
        <property type="entry name" value="KIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="248" mass="27224" checksum="1EBE1DC8C77978C9" modified="2016-04-13" version="1">MEGVESKITPEISTCLAENVEGFQKCVEEILKLIEWDADFFEITTQIYDHKNSKLTTQVTELSRMYTALADQDGHLIGEFSRNCPSGIEKQHLDASDSSSPQTFEDENTKLKSRMHENESIIEIASDMQSQLELAQDELITSPEQVSSVTACSYGDVVFDTEALDSIAALPGSVLHSSSGPSAKNSFQQQPFHKSHDRSSIGENKVLCEGNAHNVNLNSSGCTTGCQIQPLELLTNSESDSLHYTGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y256</accession>
    <name>A0A103Y256_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="4 13">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_020598</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="4 13"/>
    <dbReference type="EMBL" id="LEKV01003128">
        <property type="protein sequence ID" value="KVI01134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y256"/>
    <dbReference type="STRING" id="59895.A0A103Y256"/>
    <dbReference type="Gramene" id="KVI01134">
        <property type="protein sequence ID" value="KVI01134"/>
        <property type="gene ID" value="Ccrd_020598"/>
    </dbReference>
    <dbReference type="OMA" id="AGLDFHI"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07510">
        <property type="entry name" value="HAD_Pase_UmpH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000447">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF75">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01139">
        <property type="entry name" value="C2.A:_Pyridoxal_Phosphate_Phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00039">
        <property type="entry name" value="phosphoglycolate_phosphatase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVI01134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="306" mass="33702" checksum="71F24A19AE3E1948" modified="2016-04-13" version="1">MGDQKLTPPCHHLSPTNVRDLFDSLDAFLFDCDGVIWKGDTLIDGVPQTLEMLRSKGKKLVFVTNNSTKSRRQYAQKFQSLGISVTEEEIFSSSFAAAMYLKVNKFPPEKKVYVIGGEGILEELKLAGFTGIGGPEDAKKIVQLKANTLFEHDKSVGAVVVGLDQYINYYKLQYGTLCIRENPGCIFIATNRDATGNMTDLQEWPGAGCMVAAICGSTEKEPIVVGKPSTFLMDFLQKKYNIPTSKMCMVGDRLDTDILFGQNAGCTTLLVLSGVTSQSTLQDPSNQIQPDYYTNQISDILDLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2K0</accession>
    <name>A0A103Y2K0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_020366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003111">
        <property type="protein sequence ID" value="KVI01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2K0"/>
    <dbReference type="STRING" id="59895.A0A103Y2K0"/>
    <dbReference type="Gramene" id="KVI01364">
        <property type="protein sequence ID" value="KVI01364"/>
        <property type="gene ID" value="Ccrd_020366"/>
    </dbReference>
    <dbReference type="OMA" id="ACGRMYK"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009627">
        <property type="term" value="P:systemic acquired resistance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22269">
        <property type="entry name" value="DPBB_EG45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000005">
        <property type="entry name" value="Barwin-related endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044206">
        <property type="entry name" value="EGC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47295:SF10">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47295">
        <property type="entry name" value="EG45-LIKE DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119333" evidence="4">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="5">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="129" mass="13526" checksum="6B391B8DB1F860A6" modified="2016-04-13" version="1">MGSVIKALILIATVACLTSVAHSIAGQATFYTPPYVPSSCFGYQDRGVMILAANRGLFAGRAACGRRYRVRCTGPTNAGVPQPCTGKSVDVTVVDLCPGCAGNQVDLSQEAFAVIANRNAGRINIQYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y350</accession>
    <name>A0A103Y350_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_020083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002917">
        <property type="protein sequence ID" value="KVI01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y350"/>
    <dbReference type="STRING" id="59895.A0A103Y350"/>
    <dbReference type="Gramene" id="KVI01641">
        <property type="protein sequence ID" value="KVI01641"/>
        <property type="gene ID" value="Ccrd_020083"/>
    </dbReference>
    <dbReference type="OMA" id="ACVLEHE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF4">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="426" mass="48352" checksum="EDE34D418889AEAB" modified="2016-04-13" version="1">MVLRMIDRLDMLTADVSDEDARDDGRIRRLVSCVFLILANVLAERLMFFSERFDPKLFITRIHQFTAAADLEAGALALKTDLIGRTQQRKQLVKENFDCFVSCKTTIDDIESKLQMIEDDPEGCGTAHLNTCIQGVNSLANRAFEPLLERQAQAEKIRAVQGVLQRFRTLFNLPSAIRGNISKGEYDLAVREYRKAKSIVLPSHGGMLKRVLEEVEKVIHEFKGMLYQSMEDPQIDLTNLENVVRLLLELEPESDPVRRYFSIQNRRIRCLLEKCTSDHESRMETLQNKLHEKALSDEKWKKIQQDLHESVSNADVDCSLRYPSNLFVDTQTSDSGSDELDALRGRYIRRLTAVLIHHIPSFWKVALSVSSGKFAKVSEQNISTPANMTEEKAGHPLEVASGMIHNTISAYESKVEVFSGNLGHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y359</accession>
    <name>A0A103Y359_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002811">
        <property type="protein sequence ID" value="KVI01679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y359"/>
    <dbReference type="STRING" id="59895.A0A103Y359"/>
    <dbReference type="Gramene" id="KVI01679">
        <property type="protein sequence ID" value="KVI01679"/>
        <property type="gene ID" value="Ccrd_020042"/>
    </dbReference>
    <dbReference type="OMA" id="GFPFIRI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF551">
        <property type="entry name" value="2-HYDROXYISOFLAVANONE DEHYDRATASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI01679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="304" mass="33972" checksum="A56607F6FD4444C5" modified="2016-04-13" version="1">MLSDQEEEVTVELLPFLRVRKDGTVERLYNPTLSPPSPSATTTGVCSKDTVISPNVSARIYLPNPASLHSKKLPILVYFHGGGFCIESAFSTHCHRYITTIASLANALIVSVDYRLAPENPLPAAYEDSWTALQWVASHANKEHNKKDEPWLVQHADFDRLYIDLHGRVKILGVFLSHPYFLGSKPLGSEPITGREMSLLYKTWIIAYPGAPDGIDNPRINPFAKTAACLTGLGCRRLMICVASEDELRDRGVRYYDAVKESGWQGEISLFEVQGEGHSFHIFNPETKNAMEMFTRLAGFLQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3S0</accession>
    <name>A0A103Y3S0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein alpha subunit, helical insertion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_019750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3S0"/>
    <dbReference type="STRING" id="59895.A0A103Y3S0"/>
    <dbReference type="Gramene" id="KVI01956">
        <property type="protein sequence ID" value="KVI01956"/>
        <property type="gene ID" value="Ccrd_019750"/>
    </dbReference>
    <dbReference type="OMA" id="MLPRSAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053057">
        <property type="entry name" value="XLG_GTP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36486">
        <property type="entry name" value="OS01G0977800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36486:SF4">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="737"/>
            <end position="740"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="855" mass="96343" checksum="7F348701B94DEB7D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4F1</accession>
    <name>A0A103Y4F1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_019394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002658">
        <property type="protein sequence ID" value="KVI02320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI02320">
        <property type="protein sequence ID" value="KVI02320"/>
        <property type="gene ID" value="Ccrd_019394"/>
    </dbReference>
    <dbReference type="OMA" id="CEYDEPL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF544">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="2">
        <location>
            <begin position="567"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI02320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="789" mass="89291" checksum="B022231250FC43BE" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4H9</accession>
    <name>A0A103Y4H9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_019320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002654">
        <property type="protein sequence ID" value="KVI02362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4H9"/>
    <dbReference type="STRING" id="59895.A0A103Y4H9"/>
    <dbReference type="Gramene" id="KVI02362">
        <property type="protein sequence ID" value="KVI02362"/>
        <property type="gene ID" value="Ccrd_019320"/>
    </dbReference>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI02362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="325" mass="35060" checksum="85A0EF77F25A84B8" modified="2016-04-13" version="1">MVRMELLKKDLTDEIKSRFFHLQISLEMESPFKPEILKGKVALLTGGASGIGLEISTQFGKHGASIAIMGRRKTIVDSAVSSLQSLGIPAVGFAGDVRNQKDAKRVVESTIERYGKLDILVNAAAGNFLVSPEDLSPNGFRTVMDIDSVGTFTMCHEALNYLKKGAAGRSSDSGGIILNISATLHYTAAWYQIHVAAAKAAVDAITRNLALEWGTDYDIRVNGIAPGPISDTPGMRKLGPDEIKSKSREVMPLFKLGEKWDIAMAAIYLASDTGKYVNGTTLIVDGGLWLSRPRHLPKGEVKLLSRVVEKRARATPTGVPPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4N0</accession>
    <name>A0A103Y4N0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein beta WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_019241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4N0"/>
    <dbReference type="STRING" id="59895.A0A103Y4N0"/>
    <dbReference type="Gramene" id="KVI02449">
        <property type="protein sequence ID" value="KVI02449"/>
        <property type="gene ID" value="Ccrd_019241"/>
    </dbReference>
    <dbReference type="OMA" id="DSRVHTY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="398" mass="43697" checksum="825748BCDFD99FA8" modified="2016-04-13" version="1">MPILLECSLETLVFFADKARICEWLAHDNAIFDVCWIKIKLWDSEERKDLAVLTGHTGSVKSISAHPSNYDMIVSGSRDGSFALWDLRSSKLVPGAHSSNNKARGRHGKAASMSITSVLYLKDEVSIATAGAADSVVMFWDTRNLTAPVTKVWSHDNRPRKWSKYQVRSHGISSLSQDLNGVYISASCMDSRIYLYNVLRLEDGPVKSFSGCDISTFFVKSSLSPDAAHILSGSSDGNAYVWQVDKPQADPIKLNGHGGEVTAVDWCSSEIGKIATTADDSVVRLWNINTSCYSNTRSTSSIRRRLFALPKTDRTMLFTNEPEPDSPLEPLVQISSPNPSSNPEMRTPESLGKQSSKSYIREPCDGSPDATLGSPSSVLNPPPSLKRKTILDYFLAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4X7</accession>
    <name>A0A103Y4X7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_019118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002650">
        <property type="protein sequence ID" value="KVI02592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4X7"/>
    <dbReference type="Gramene" id="KVI02592">
        <property type="protein sequence ID" value="KVI02592"/>
        <property type="gene ID" value="Ccrd_019118"/>
    </dbReference>
    <dbReference type="OMA" id="QETIMEP"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000025">
        <property type="entry name" value="putative methylesterase 11, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF872">
        <property type="entry name" value="METHYLESTERASE 11, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI02592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="382" mass="42461" checksum="2484C3D2AE088A4A" modified="2016-04-13" version="1">MGICFSRKSTRATRIYSKRIANQSSASINKSSVNRWSRVRSSSVKKEKFDDALLHEQAIAAALLFQQHQQNGDYLPHFDRSTSIRHPPGGANSKCQQVVSRSSSTRRRSVTDPMPPPHLIQEVKHDELETSHIVLVHGGGFGAWCWYKTIALLQECKFKVTAIDSSGSGINQFDANAIGSLSQHVKPLTDFLEKLADGEKVILAGHDFGGACISYAMELYPSKVAKAIFIAASMLKTGQSTLDMFSHKENTNDLMRQAQKFLYANGNNQPPTAIDLDKSLLKDLLFNQSPAKDVALASVSMRPIPFPPVLEKLSLSDSNYGSVRRFYIETPEDNAIPITLQQRLINENPPEKVFRLKGADHCPFFSKPQALHKLLVEIAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y554</accession>
    <name>A0A103Y554_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_019017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002644">
        <property type="protein sequence ID" value="KVI02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y554"/>
    <dbReference type="STRING" id="59895.A0A103Y554"/>
    <dbReference type="Gramene" id="KVI02704">
        <property type="protein sequence ID" value="KVI02704"/>
        <property type="gene ID" value="Ccrd_019017"/>
    </dbReference>
    <dbReference type="OMA" id="ARETGFF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="292" mass="32599" checksum="856DFB14396DB1FD" modified="2016-04-13" version="1">MSTDFQSIPLIDISPLVAKCDDPDVGEDKDVAEVVRLLDQACREAGFFYVKGHGIPDSLIKEVRDMTHEFFDLPYEEKLKIKLSDATGYRGYQRVGENITKGIPDRHEAIDCYKELNKGMYGELSRKIMRGIALALGGSVDEFEGKIAGDPFWVFRIIGYPGAEGLQKNDVGCGAHTDYGKFLQFRLGIPWIIVRNVSGEWISAVPIPGTFVCNIGDMLKILTNGLYESTLHRVVNNSPKFRVCVAYFYEPNFNAAISPLDMCVKKSGGNKKFESAVYGEHLVSKVLTNFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5L0</accession>
    <name>A0A103Y5L0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002610">
        <property type="protein sequence ID" value="KVI02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5L0"/>
    <dbReference type="STRING" id="59895.A0A103Y5L0"/>
    <dbReference type="Gramene" id="KVI02954">
        <property type="protein sequence ID" value="KVI02954"/>
        <property type="gene ID" value="Ccrd_018753"/>
    </dbReference>
    <dbReference type="OMA" id="CAYIIMA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004320">
        <property type="entry name" value="BPS1_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070:SF109">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF241)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070">
        <property type="entry name" value="OS06G0725500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03087">
        <property type="entry name" value="BPS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56258" checksum="7096C73420415BD6" modified="2016-04-13" version="1">MDASASFSSSSTSVRHVRSISLPNQSHPSTLQVEEELTYLKTWETSSSSIATVDTVCGSLAALERLYTSVNDLLNLPLTQQALFTKDEKLVDELLDRSMRLLDVCGSIKDAMEQVREHVKNVQSALRRKKAYLTMDASSLRKLMKDANRAILALKKIDNKIGDNIALLNLDDHLSAVIRSLRDASAVSVSVFGSVLSLESIFLSKPKSTKWSVVSNLIRKGNRVSVNHPQISDEALESHIEVIQNPSSSSSSTSVRHVRSISLPSQSHPSTLQVEEELTYLKTWEASSSSMATVDTVCGSLVVLERLYTSVNNLLSLPLTQQALFTKDEKLVDELLDRSMKLLDVCGSIKDTMEQVKEHVKNVQSALRRKKSNLSMDASLLRKLMKDANRAISALKKSDNKTGDDIALLDLDHHLSTVIRSLRNAGEVSISIFGSVLSLKSIFVSKPKSTKWSVVSNLIWKGNTMSIDQPQISNEALESHIEVIQSSLECVFRTLMKTRVCLLNIRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y827</accession>
    <name>A0A103Y827_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor IIIC, subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_017459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002294">
        <property type="protein sequence ID" value="KVI04225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y827"/>
    <dbReference type="STRING" id="59895.A0A103Y827"/>
    <dbReference type="Gramene" id="KVI04225">
        <property type="protein sequence ID" value="KVI04225"/>
        <property type="gene ID" value="Ccrd_017459"/>
    </dbReference>
    <dbReference type="OMA" id="NDANMRC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.160:FF:000002">
        <property type="entry name" value="Transcription factor IIIC, subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="230"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI04225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="419" mass="47591" checksum="9D28898A20E48AB7" modified="2016-04-13" version="1">MGVIKDGTIAGVLPNNKLFAVNYPGYPSSMERALVTLGGAEGIAKVRQSPSNNLELHFRPEDPYSHPVIGERFPCNNFLLKISKHNTKGSQSETDSSAHLKEDEALSQGSEDKIYANIIGCVPEAYYFNGMVDYQHVLAVHADIVQRKKRNWADVEPQFEKRGLIDADQEDLMILLPPLFSVKNIPENVVLKPSIDSSTKKKQEGAMQYPEKVKWEMFIQEGTDDWNYQMAVCELFDERPIWIKQSLSEHLSDKGLKIGDNTMKMLLFVAAYYFSNGPFLKFYIRRGYDPRKDSESRMFLSVYPDPGAESLLKSASLRLGKLKRTKPVIKEQTVNEEEHQQLNRENVITEEKEMSSDEDDDGVDDDDDDDDSGGKRNMRAFSDFQVRMLLGNLRTRSFPSDGNQQIHNFQVKATVSCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y854</accession>
    <name>A0A103Y854_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein TypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002256">
        <property type="protein sequence ID" value="KVI04274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y854"/>
    <dbReference type="STRING" id="59895.A0A103Y854"/>
    <dbReference type="Gramene" id="KVI04274">
        <property type="protein sequence ID" value="KVI04274"/>
        <property type="gene ID" value="Ccrd_017415"/>
    </dbReference>
    <dbReference type="OMA" id="MYKTEIG"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.250:FF:000001">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="entry name" value="bipa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048876">
        <property type="entry name" value="BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21018">
        <property type="entry name" value="BipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TypA/BipA C-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="141" mass="15937" checksum="AF8D9E91701024AB" modified="2016-04-13" version="1">MHRAFMAYEKYRGPLGNVRKGVLVSCARGTTTSYALMSLEPRGTLFVSPGVEAYDGMIVGEHSRDTDLDVNPVRNKELTNIRSAGKDENVKLSPPRRMTLEEAIGYVASDELIEVTPHNIRLRKRYLDANKRKTMSKRPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y8K3</accession>
    <name>A0A103Y8K3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_017174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002020">
        <property type="protein sequence ID" value="KVI04507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y8K3"/>
    <dbReference type="STRING" id="59895.A0A103Y8K3"/>
    <dbReference type="Gramene" id="KVI04507">
        <property type="protein sequence ID" value="KVI04507"/>
        <property type="gene ID" value="Ccrd_017174"/>
    </dbReference>
    <dbReference type="OMA" id="WMVYKCA"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000212">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="178"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI04507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="44706" checksum="0E641EB0C1AC1AA7" modified="2016-04-13" version="1">MNALAATNRNFRHAARLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLVSYVGFRVQHDNSRGPMKGGIRYHPEVDPDEVNALAQLMTWKTAVADIPYGGAKGGIGVTPRDLTLSELERLTRVFTQKIHDLIGVNTDVPAPDMGTNAQTMAWILDEYSKFHGHSPAIVTGKPIDLGGSLGRDAATGRGVVFATEALLAEHGKSIKDMTFAIQGFGNVGSWASRLIQERGGKIVAVSDVTGAVKNLNGIDILALLKHKETTGSLSNFNGGDSMNADELLVYECDVLIPCALGGVLNRENAGEVKAKFIIEAANHPTDPEADEILSKKGVIILPDIYANAGGVTVSYFEWVQNIQGFMWDEEKVNDELKKYMTKAFHNIKSMCQTHECSLRMGAFTLGVNRVARSTLLRGWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAA2</accession>
    <name>A0A103YAA2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_016267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001873">
        <property type="protein sequence ID" value="KVI05405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YAA2"/>
    <dbReference type="STRING" id="59895.A0A103YAA2"/>
    <dbReference type="Gramene" id="KVI05405">
        <property type="protein sequence ID" value="KVI05405"/>
        <property type="gene ID" value="Ccrd_016267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17041" checksum="AD2C9B87CFCEE269" modified="2016-04-13" version="1">MGYLSCKAESTIAVHNPSKKSDKIHGNEDLIHKKIQHFDYSDLEAATNNFSDQKLLGRGRLVAVKKPSHQNNHHSALSAVPENEVENEIDILSKLHSPRLRVPTVACRLRSSHRRRPTVACRLRSNRRRPTVACQRVPIDGDHLIETTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YAT4</accession>
    <name>A0A103YAT4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">alpha-glucan, water dikinase</fullName>
            <ecNumber evidence="15">2.7.9.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_016003</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.4" evidence="15"/>
    <dbReference type="EMBL" id="LEKV01001865">
        <property type="protein sequence ID" value="KVI05666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YAT4"/>
    <dbReference type="Gramene" id="KVI05666">
        <property type="protein sequence ID" value="KVI05666"/>
        <property type="gene ID" value="Ccrd_016003"/>
    </dbReference>
    <dbReference type="OMA" id="IFVWIRF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050521">
        <property type="term" value="F:alpha-glucan, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000033">
        <property type="entry name" value="alpha-glucan water dikinase, chloroplastic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055495">
        <property type="entry name" value="CWD_DUF7067"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056301">
        <property type="entry name" value="GWD-like_N_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054481">
        <property type="entry name" value="GWD1_pHisD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46999:SF1">
        <property type="entry name" value="ALPHA-GLUCAN WATER DIKINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46999">
        <property type="entry name" value="ALPHA-GLUCAN WATER DIKINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23229">
        <property type="entry name" value="DUF7067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22973">
        <property type="entry name" value="GWD1_pHisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23166">
        <property type="entry name" value="Ig_N_CWD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alpha-glucan water dikinase-like N-terminal Ig-like" evidence="19">
        <location>
            <begin position="91"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7067" evidence="20">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7067" evidence="20">
        <location>
            <begin position="274"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glucan water dikinase-like N-terminal Ig-like" evidence="19">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glucan water dikinase phosphohistidine-like" evidence="18">
        <location>
            <begin position="909"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="17">
        <location>
            <begin position="1164"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVI05666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152392" checksum="D1639B863C521085" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YBB2</accession>
    <name>A0A103YBB2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1677 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_015715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBB2"/>
    <dbReference type="STRING" id="59895.A0A103YBB2"/>
    <dbReference type="Gramene" id="KVI05935">
        <property type="protein sequence ID" value="KVI05935"/>
        <property type="gene ID" value="Ccrd_015715"/>
    </dbReference>
    <dbReference type="OMA" id="SSHMNTC"/>
    <dbReference type="OrthoDB" id="673856at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012876">
        <property type="entry name" value="DUF1677_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33108:SF83">
        <property type="entry name" value="DUF1677 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33108">
        <property type="entry name" value="OS01G0745000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07911">
        <property type="entry name" value="DUF1677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI05935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20337" checksum="BEFB2A32442DEF97" modified="2016-04-13" version="1">MAPHGDTIVTQCAHPKHSFSKPPRLSSDALKRTVSDMSFELSKDAIDIKSLTTISEVVDAKCECCGMVEECTPEYMENIHNRFLGKWICGLCSEAVKEEMEKNGGNKEAALSSHMNTCVRFNKRDRAYPVLCQAEAMRDLLKKTRLRGKSLSPRDTGSVKRGGIARSSSCIPAITKEINGVNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YCD8</accession>
    <name>A0A103YCD8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_015171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001823">
        <property type="protein sequence ID" value="KVI06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YCD8"/>
    <dbReference type="STRING" id="59895.A0A103YCD8"/>
    <dbReference type="Gramene" id="KVI06486">
        <property type="protein sequence ID" value="KVI06486"/>
        <property type="gene ID" value="Ccrd_015171"/>
    </dbReference>
    <dbReference type="OMA" id="ANEDACI"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF52">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="17819" checksum="E51F1AC425CD8B29" modified="2016-04-13" version="1">MSGLPEDQLQQLREIFARFDLDKDGSLTHLEVAALLRSLGLKPTGEQIHKLFKNMDSDGSGTVEFDELVNAMSSQMMSEDILINQHQLLEIFQSFDRDGSGFITPAELAKSMTKMGQPLTYRELSEMVRNADTDGDGVISFKEFQGIMAKSAADSFGFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YD91</accession>
    <name>A0A103YD91_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_014687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001538">
        <property type="protein sequence ID" value="KVI06951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YD91"/>
    <dbReference type="STRING" id="59895.A0A103YD91"/>
    <dbReference type="Gramene" id="KVI06951">
        <property type="protein sequence ID" value="KVI06951"/>
        <property type="gene ID" value="Ccrd_014687"/>
    </dbReference>
    <dbReference type="OMA" id="MQINIQP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000194">
        <property type="entry name" value="Actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI06951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24999" checksum="5E47E00E270ECA1B" modified="2016-04-13" version="1">MPFISQTQRQSDYNLIPPSCPIVIDNGASYFRIGWAGESEPRIIFRNIVQRPRHKITGETVTIVGDHDPALLKYFDCTRSGPRSAFDNNVVFQFEIMEYILDFAFDRLGADQTPINHPILITECACNPVQSRSKMAELLFETYGVPSIAFGVDAAFSYKYNQQLGICDRDGLAICSGFTTSHVIPFINGEPAYEACCRTNVGGYHVTDYLKQLLSLKYPHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDD6</accession>
    <name>A0A103YDD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_014613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001529">
        <property type="protein sequence ID" value="KVI07029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDD6"/>
    <dbReference type="STRING" id="59895.A0A103YDD6"/>
    <dbReference type="Gramene" id="KVI07029">
        <property type="protein sequence ID" value="KVI07029"/>
        <property type="gene ID" value="Ccrd_014613"/>
    </dbReference>
    <dbReference type="OMA" id="TICHFTI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000104">
        <property type="entry name" value="trihelix transcription factor ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044823">
        <property type="entry name" value="ASIL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307:SF40">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ENAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="9">
        <location>
            <begin position="367"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI07029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="549" mass="61292" checksum="50B3548FC87E61A8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDN4</accession>
    <name>A0A103YDN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24e, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_014464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001515">
        <property type="protein sequence ID" value="KVI07178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDN4"/>
    <dbReference type="STRING" id="59895.A0A103YDN4"/>
    <dbReference type="Gramene" id="KVI07178">
        <property type="protein sequence ID" value="KVI07178"/>
        <property type="gene ID" value="Ccrd_014464"/>
    </dbReference>
    <dbReference type="OMA" id="QVFRRMH"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF51">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL24Y-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="18336" checksum="D1AA474BECBF4191" modified="2016-04-13" version="1">MVLKTELCRFSGQKIYPGRGIRFIRSDSQVFLFANSKCKRYFHNKLKPSKLTWTAMFRKQHKKDIAQEAVRKRRRATKKPYSRAIVGATLEVIQKKRAEKPEVRDAAREAALREIKERIKKTKDEKKAKKAEVVSKQKTQGKGGNVPKGKGPKLGGGGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEH3</accession>
    <name>A0A103YEH3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_014058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001502">
        <property type="protein sequence ID" value="KVI07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEH3"/>
    <dbReference type="STRING" id="59895.A0A103YEH3"/>
    <dbReference type="Gramene" id="KVI07581">
        <property type="protein sequence ID" value="KVI07581"/>
        <property type="gene ID" value="Ccrd_014058"/>
    </dbReference>
    <dbReference type="OMA" id="YAGIFGM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000050">
        <property type="entry name" value="glucose-6-phosphate exchanger SLC37A2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="531" mass="57851" checksum="46BC8E35A3918548" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEN5</accession>
    <name>A0A103YEN5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_013952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001495">
        <property type="protein sequence ID" value="KVI07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEN5"/>
    <dbReference type="Gramene" id="KVI07687">
        <property type="protein sequence ID" value="KVI07687"/>
        <property type="gene ID" value="Ccrd_013952"/>
    </dbReference>
    <dbReference type="OMA" id="WISSEVY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF573">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="246" mass="29405" checksum="B548F8EE6634091B" modified="2016-04-13" version="1">MAREIVREESNIPGKRSRLWISSEVYDVLNKNEGTEAVEVLHLLVREYYPKVHIDGKGFAQMKNLRILKIYDEELRHRWHAFDLKLWKESKVNYDGKLKFLSNKLRLLYWHGFPFKCFPSDFYPENIIAIDLSYSHIKNLWTSPKVDMRRGFGLDGGVQFLKLHGFQSWIHSKHRHRSWQKAKNFVTVSIGHDDDFEVKECGFRLVFDEDIEEETNFSLIQEFQTPTQEGGAIKMRRNNQHFNWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGL7</accession>
    <name>A0A103YGL7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_012860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001091">
        <property type="protein sequence ID" value="KVI08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGL7"/>
    <dbReference type="STRING" id="59895.A0A103YGL7"/>
    <dbReference type="Gramene" id="KVI08739">
        <property type="protein sequence ID" value="KVI08739"/>
        <property type="gene ID" value="Ccrd_012860"/>
    </dbReference>
    <dbReference type="OMA" id="EYFQHRY"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF114">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="202"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="412"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="667"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="821" mass="92428" checksum="F987D0DC63FB8CF4" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGM3</accession>
    <name>A0A103YGM3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_012924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001096">
        <property type="protein sequence ID" value="KVI08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGM3"/>
    <dbReference type="STRING" id="59895.A0A103YGM3"/>
    <dbReference type="Gramene" id="KVI08708">
        <property type="protein sequence ID" value="KVI08708"/>
        <property type="gene ID" value="Ccrd_012924"/>
    </dbReference>
    <dbReference type="OMA" id="MEICWNT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37740">
        <property type="entry name" value="OS02G0193500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37740:SF1">
        <property type="entry name" value="OS02G0193500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="95" mass="10811" checksum="50E1842118885C62" modified="2016-04-13" version="1" fragment="single">PSKRSSKKEAPQTFQQQEKSNSDSLPDSSTGDEYRSLRRKYLLLEEESFNLGRETKDIQDAVNSLEEEKLSLLDELVVLEGLVDPSELDASRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YI23</accession>
    <name>A0A103YI23_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_012081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001057">
        <property type="protein sequence ID" value="KVI09516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YI23"/>
    <dbReference type="STRING" id="59895.A0A103YI23"/>
    <dbReference type="Gramene" id="KVI09516">
        <property type="protein sequence ID" value="KVI09516"/>
        <property type="gene ID" value="Ccrd_012081"/>
    </dbReference>
    <dbReference type="OMA" id="WHVYEES"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048653">
        <property type="term" value="P:anther development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080186">
        <property type="term" value="P:developmental vegetative growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009553">
        <property type="term" value="P:embryo sac development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034089">
        <property type="term" value="P:establishment of meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060772">
        <property type="term" value="P:leaf phyllotactic patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI09516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="40289" checksum="ECDE3E94A2F94F57" modified="2016-04-13" version="1">MQLKINSFFKSSSPSTVQRETLDLPLSPLEDLSNEVDFTKEPEIPIIYTRRAPNSDRRDDGEWTGKDPKKLDSRRPLVVVKSEKVLNKKRKYAQFHLDLGQSDFLLRTCKTCGFKFAPGDEGDEKAHKEFHKNYTHGIGFKGWRNERVIDMLSLECGRVILVLKDDPPAHSKKVKEVIGMMETELGDGWIFHEQCKVYLFICSQRVAGCLVAESINKAYQLVSNSDEKSDVTTAPEEDRRLTSTTLKFGGVSFQREIVTKNPLAKNERKANDDLLGAIICEKDAVPAVCGIRAIWVTPSNRRKHIATHLLEATRKSFCPGLSLEHRQLAFSQPTNVGKLLASSYTNTKSILVYTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJQ5</accession>
    <name>A0A103YJQ5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_011249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001021">
        <property type="protein sequence ID" value="KVI10349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJQ5"/>
    <dbReference type="Gramene" id="KVI10349">
        <property type="protein sequence ID" value="KVI10349"/>
        <property type="gene ID" value="Ccrd_011249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI10349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="416" mass="42841" checksum="4F7B8DAFD1986FC1" modified="2016-04-13" version="1">MIIVSSLCCDSLFHYSHYLCTSSNQQQMKTDTRVPMSLVANRLHVSWVPNPHLPAASHVVNRQLPVSCLVISFPVSHEELTSFYECLTKFGDCTSQPFSIKNGCFLDILQLTTQPGHHLKTKGAIIFICISLTRISSSFFFKKIIGFKAGGTLGLLGCFRSSNTFCPNDLQYYKMQKSQTALQFQGEKDPRYTALASTPPLQLVPSSAITSGDEVGVNNDSKELPSLSASQTSFVVTFRVAITLSQKNGFSLALLESSASGSPGPNAWRGVLRPPPGGRGGALPPLGGGGGRGPSFRGGGGGGAPPDGGGGGGGRLAEGARRGGGEGAAAGAGVGDGDGTAAGDRGGAEAVLADGGCTDRSVLPGGGFNVDSALPGGGFRGGILEALKLSGGSSDAKANDTLEFTEESVFCRSGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSD3</accession>
    <name>A0A118JSD3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005361">
        <property type="protein sequence ID" value="KVH88617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A118JSD3"/>
    <dbReference type="Gramene" id="KVH88617">
        <property type="protein sequence ID" value="KVH88617"/>
        <property type="gene ID" value="Ccrd_026313"/>
    </dbReference>
    <dbReference type="OMA" id="QSMRMMN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="84"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="3">
        <location>
            <begin position="380"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH88617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1415" mass="159461" checksum="8CF7D3EB8364FB02" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT12</accession>
    <name>A0A118JT12_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_007835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005115">
        <property type="protein sequence ID" value="KVH90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT12"/>
    <dbReference type="STRING" id="59895.A0A118JT12"/>
    <dbReference type="Gramene" id="KVH90157">
        <property type="protein sequence ID" value="KVH90157"/>
        <property type="gene ID" value="Ccrd_007835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01958">
        <property type="entry name" value="HPS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027923">
        <property type="entry name" value="Hydrophob_seed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051636">
        <property type="entry name" value="Plant_LTP/defense-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14547">
        <property type="entry name" value="Hydrophob_seed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159637" evidence="1">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrophobic seed protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="15215" checksum="E2A9BABA26D90828" modified="2016-04-13" version="1">MASSALRTMAFLLALNLLFFTLVSSQTLPAEATCPTTGLKFGVCAGFLSNLLGGIVVGTPPSIPCCNLIFGLVDLEAAACLCKAIKANLLGTNLDASASFNLVYNNCGKEVPSGPSEIRHPSLPRRSVRDGCRIPVDEALLMNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT23</accession>
    <name>A0A118JT23_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005315">
        <property type="protein sequence ID" value="KVH89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT23"/>
    <dbReference type="STRING" id="59895.A0A118JT23"/>
    <dbReference type="Gramene" id="KVH89052">
        <property type="protein sequence ID" value="KVH89052"/>
        <property type="gene ID" value="Ccrd_008964"/>
    </dbReference>
    <dbReference type="OMA" id="GNYYQHN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF696">
        <property type="entry name" value="OS07G0601900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="40738" checksum="6F58593A25A9D837" modified="2016-04-13" version="1">MESKSRCKVCVTGGAGYIGSALIHSLLQIGYTVHATLRNLEERLHLFEADIYKPQEFEEAIQGCVYVFHVATPIYHTSGYKYNDKIEATISAIKKIADVCIQSRTVRRLIYTASVVAASPLKDDGSGYKTTMDESCWTPLYISVPYSNDFVKEYTEAKTRAEQEILKIGEDKANELEVVTLSCGLVGGGGHLPYTTSSVMLLISQVINNETQYQMLRYLEELMGKIPIVHIKDVCRAHIFCIEMPMVNGRFLCSSSYITGTWKDQRGISNGAQESLKMKGFLTNTMSRRSWMIVSNMQRDQAISNKNLSLCFVSCFRYTEGPKREIKWGSTKLRDKGFSYKHDTKTTLDDCIECAMRSDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT29</accession>
    <name>A0A118JT29_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005325">
        <property type="protein sequence ID" value="KVH88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT29"/>
    <dbReference type="Gramene" id="KVH88930">
        <property type="protein sequence ID" value="KVH88930"/>
        <property type="gene ID" value="Ccrd_024667"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726162at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159645" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15271" checksum="BF26CEC3B9CECD6B" modified="2016-04-13" version="1">MKTILSPLLAILIIHHLLQANSASIQPDPGTVISGRNRYLRTLPSSPPSPELDRSSHYFSFFQPPPPPTEQMQSTTTNFRVVRKGSPPAPKVSRPRNFRIPYLPKPRPPLSPLLPPPSPPLVAGPPTKYNIPPPPPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JT52</accession>
    <name>A0A118JT52_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF936 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_008374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005193">
        <property type="protein sequence ID" value="KVH89636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JT52"/>
    <dbReference type="STRING" id="59895.A0A118JT52"/>
    <dbReference type="Gramene" id="KVH89636">
        <property type="protein sequence ID" value="KVH89636"/>
        <property type="gene ID" value="Ccrd_008374"/>
    </dbReference>
    <dbReference type="OMA" id="FANGVKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049172">
        <property type="entry name" value="DUF6857_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048297">
        <property type="entry name" value="DUF936_dom_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010341">
        <property type="entry name" value="DUF936_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928:SF4">
        <property type="entry name" value="OS08G0541500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21647">
        <property type="entry name" value="DUF6857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06075">
        <property type="entry name" value="DUF936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF936" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="390"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH89636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="79340" checksum="994CABBD1D4FC1A0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUI3</accession>
    <name>A0A118JUI3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_005858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004851">
        <property type="protein sequence ID" value="KVH92111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUI3"/>
    <dbReference type="Gramene" id="KVH92111">
        <property type="protein sequence ID" value="KVH92111"/>
        <property type="gene ID" value="Ccrd_005858"/>
    </dbReference>
    <dbReference type="OMA" id="RIPMHAM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="3">
        <location>
            <begin position="141"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH92111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="782" mass="86732" checksum="5E3B5DD5F18170C9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JV80</accession>
    <name>A0A118JV80_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_005569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004820">
        <property type="protein sequence ID" value="KVH92382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JV80"/>
    <dbReference type="Gramene" id="KVH92382">
        <property type="protein sequence ID" value="KVH92382"/>
        <property type="gene ID" value="Ccrd_005569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH92382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="94" mass="10736" checksum="1966762DCF2F5702" modified="2016-04-13" version="1">MAIATYFNSITTIERRLSTSSECSSTSSGSDGEQYVKVDSNVRRSRKWRKMMKKLVEESKKSIYGTSKSLTFGYDAVSYSLNFDEGNHSDEYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVE4</accession>
    <name>A0A118JVE4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Ccrd_005310</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01004811">
        <property type="protein sequence ID" value="KVH92652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVE4"/>
    <dbReference type="STRING" id="59895.A0A118JVE4"/>
    <dbReference type="Gramene" id="KVH92652">
        <property type="protein sequence ID" value="KVH92652"/>
        <property type="gene ID" value="Ccrd_005310"/>
    </dbReference>
    <dbReference type="OMA" id="NCLALQI"/>
    <dbReference type="OrthoDB" id="1896041at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048508">
        <property type="term" value="P:embryonic meristem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009942">
        <property type="term" value="P:longitudinal axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009945">
        <property type="term" value="P:radial axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000192">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000260">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000679">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF63">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007159714" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="27"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="828"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="856"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KVH92652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120124" checksum="1C0807FE2E8D9BD7" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWH1</accession>
    <name>A0A118JWH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004544">
        <property type="protein sequence ID" value="KVH94597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWH1"/>
    <dbReference type="STRING" id="59895.A0A118JWH1"/>
    <dbReference type="Gramene" id="KVH94597">
        <property type="protein sequence ID" value="KVH94597"/>
        <property type="gene ID" value="Ccrd_003337"/>
    </dbReference>
    <dbReference type="OMA" id="CESGMIT"/>
    <dbReference type="OrthoDB" id="778241at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012862">
        <property type="entry name" value="DUF1635"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431:SF12">
        <property type="entry name" value="HIGH MOBILITY GROUP BOX PROTEIN, PUTATIVE (DUF1635)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07795">
        <property type="entry name" value="DUF1635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33342" checksum="980CE413B8438BE9" modified="2016-04-13" version="1">MEEMSSLWSYQESVDELKLKIQYTAQELEAVKARANEEMNRNSESVKQLLQLLKFVCHERDQARDQIQKLFIKIMPPMHNTMMISDCFAIDQLHHLHQSPLSKPAKANSSMAESNSFSDAYNHCLSPVDSLFDPVTSPEFSNMNTNTTLVSANGLHASGSVPKTDHATLMMESMIKGKTLPRKGNLLQAVMEAGPLMETVLAASPVPNWQNMSLSSFHIPTVSGSNNAQNPMSMMILRQSQPFVEMSCGNFSQLTDVRGGGSSILSFDDVNLSDSRRRMVTGCPRSCSFGQIDKRQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWR2</accession>
    <name>A0A118JWR2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_002076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004375">
        <property type="protein sequence ID" value="KVH95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWR2"/>
    <dbReference type="STRING" id="59895.A0A118JWR2"/>
    <dbReference type="Gramene" id="KVH95859">
        <property type="protein sequence ID" value="KVH95859"/>
        <property type="gene ID" value="Ccrd_002076"/>
    </dbReference>
    <dbReference type="OMA" id="THGTHYN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF221">
        <property type="entry name" value="TAXADIENE 5-ALPHA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="443" mass="50326" checksum="C03B725E624B1D5D" modified="2016-04-13" version="1">MAALTFISVLASFIFLILFLRRNNRRQRPNKLKLPSGEMGLPWIGETIEFYNAQRTNQLFENFFRPRIAKYGKVFKTRLMGSPTVVVHGPAANKFFMSNEFKLVVSSWPTSSVELMGKNSIMEKQGDSHRCLRGIVTSTLSHSGLQAMVPRMCTSIQKHLQKNWQNKEEISLYRSTKMLTFTIVLECLFGIGIEPETMFGVFERILEGVLSPPVNFPGTKFSRAKKARAEIEKVLVGEVRRKREAMEGGRDEEDGMLLSKLVGALIKGEITEEEVVDNIVLLVFAAHDTTSYAITMTFKMLANHPDCYSLLLKEHEKIGGKKSPGEVLTFEDVKKMEYTWQVARETMRLCPPIFGSFRKAITDIEFEGCFIPKGWKVLWTTYGTHYDEECFPDPMSFNPSRFADPVAAYSFIPFGGGPRLCAGYQLAKLNILVLIHYVVTQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWY2</accession>
    <name>A0A118JWY2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anion-transporting ATPase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004335">
        <property type="protein sequence ID" value="KVH96309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWY2"/>
    <dbReference type="STRING" id="59895.A0A118JWY2"/>
    <dbReference type="Gramene" id="KVH96309">
        <property type="protein sequence ID" value="KVH96309"/>
        <property type="gene ID" value="Ccrd_001602"/>
    </dbReference>
    <dbReference type="OMA" id="SWYVRRF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053262">
        <property type="entry name" value="ArsA_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43868">
        <property type="entry name" value="OS02G0711200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43868:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA HSP20-like" evidence="3">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="399" mass="43139" checksum="52782123548A1F3A" modified="2016-04-13" version="1">MAFCNPPTLLPSSSYPPPPPFYSNFNRILVRSMPPRFLTITMAKSPTTQSDGNDGSTKFVTFLGKGGSGKTFSAIFAAQHYAMAGLKTCLVIHSQDPTADYLLGCKIGTTPVTCNDNLSAVRLETTKMILEPLSQLKQADARLNLTQGVLEGVMGEELGVLPGMDTIFSAMALERLVGFLKNKIQKNNPKDNFDIVTDMGRLAGPSLLRLADEALNAGTSTSGFNGQLSGEIWDKLDQLLENGSSFITNPHLFGCYLVTDLNNPISLNSALRYWGCAVQAGALISGAFGVTHLSCSEEHLETAKRTFSPLPFASYPPISFKTPLNWEDIMHNGHSNDARDLLSTSKSGSSGYVQSYRGGSELLIEAGDQRRVICLPSQIQGKVGGAKFIDRKLIITMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JX53</accession>
    <name>A0A118JX53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004458">
        <property type="protein sequence ID" value="KVH95005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JX53"/>
    <dbReference type="Gramene" id="KVH95005">
        <property type="protein sequence ID" value="KVH95005"/>
        <property type="gene ID" value="Ccrd_002932"/>
    </dbReference>
    <dbReference type="OMA" id="KGIWFCY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011230">
        <property type="entry name" value="PAP14/16/28/29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF2">
        <property type="entry name" value="INACTIVE PURPLE ACID PHOSPHATASE 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030250">
        <property type="entry name" value="Ptase_At2g46880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="382" mass="43115" checksum="5D8C70D51160BA7F" modified="2016-04-13" version="1">MQSTKSWIYALFYLTLITILLYLMQVWILSDKLMVSHHRITSKKHPNLPLRFNFDGTFKILQVADMHYGTGLTRCRDVLSSEFQWCSDLNTTLFLKRMIDAEKPDFIAFTGDNIFGSSTDDAAESLFKAFGPAMDSRLPWAAVLGNHDQESTMTREELMSFISLMDYSLSQPNPSTEDTSDPAKQQVITDIDGFGNYDLRVWGAPGSYLANQTILNLFFLDSGDRAVVNGGHKQENHQSEDIPMVPTPPPALAFFHIPIPEIRYGPFMEIFGEYHENVACSVVNSGVLQTFVSMGDVKAVFIGHDHLNDFCGNLDGIWFCYGGGFGYHGYGKAGLSRRARVILAELKKGKNEWMGVETIKTWKRIDDKKLTKIDEQILWTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXA5</accession>
    <name>A0A118JXA5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004393">
        <property type="protein sequence ID" value="KVH95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXA5"/>
    <dbReference type="Gramene" id="KVH95320">
        <property type="protein sequence ID" value="KVH95320"/>
        <property type="gene ID" value="Ccrd_002625"/>
    </dbReference>
    <dbReference type="OMA" id="MDGEMDP"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46993">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46993:SF6">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="307" mass="35224" checksum="0DE80F6D07D01400" modified="2016-04-13" version="1">MDIDVSGWILEFLLRQTSVDDHTLDELIRVLPLPDHNLSLKKSLLLRKIESDILKGTVSEPVLELLETIQELDQKEGVVEVPETMKTAYCAVAVHCALRLLRGNITKKEKYSDVVKMIWKDRALQMEKFFDMPVAASSGMEWISEELKNWMCNMKAGVWDPTSVCKNVSVMKYIKCKDVVEMVRLYVVEAKEKMGPSFLELAAEKLSGDVIKEVTDGVGKVQNEQQEGERNESSLIKGLLKRRPKRAWGFEEENALWIGVKKYGKGNWKLILTMYPDIFVGRSVVDLKDKWRNMSRYESYLESKNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXV0</accession>
    <name>A0A118JXV0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004258">
        <property type="protein sequence ID" value="KVH96657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXV0"/>
    <dbReference type="STRING" id="59895.A0A118JXV0"/>
    <dbReference type="Gramene" id="KVH96657">
        <property type="protein sequence ID" value="KVH96657"/>
        <property type="gene ID" value="Ccrd_001252"/>
    </dbReference>
    <dbReference type="OMA" id="PWGLSAW"/>
    <dbReference type="OrthoDB" id="1929829at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34656">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34656:SF1">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18410" checksum="81226E74C5B4BCE7" modified="2016-04-13" version="1">MADSTNKLEDDQPPPSTASPTYLILLRLMSKRRTWVFLFLFVYTILLSSSWNLLKSVLSWYDSTVTTSPSSSTGWPAIYASVALGVIFGLLSMAAALAVAIPATLVTWISVLVLLTFFGKPRKSLVVEGKKLTAEITRTVGKILIKEGNLVAAVCAVLGYILLVRNGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZK5</accession>
    <name>A0A118JZK5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003401">
        <property type="protein sequence ID" value="KVI00030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZK5"/>
    <dbReference type="STRING" id="59895.A0A118JZK5"/>
    <dbReference type="Gramene" id="KVI00030">
        <property type="protein sequence ID" value="KVI00030"/>
        <property type="gene ID" value="Ccrd_021712"/>
    </dbReference>
    <dbReference type="OMA" id="TRVNQWW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000008">
        <property type="entry name" value="RHOMBOID-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="432" mass="47688" checksum="7284265AEDEC0E96" modified="2016-04-13" version="1">MLIWKGLFDNRTVIKTLRTSRTTGECKPRINVQNTLPISSKQFAVNDEIKHCIGGFPTRFKQWWEGIPFLTSVVVAVCAVIYLVCLLVGYDSFAEVCFWPSAVISKFQVYRVFTSIFFHGSILHLVFNMLALVPLGSELERVMGSIRLLYMIVLLATSSAIFHLLITLIAAYNPIHSYYHFMDECAIGFSGVLFSMIVIETSLNGVQSRSVFGLFNVPAKLYPWILLVVFQLLMTNISLLGHLCGILSGFAYTYGLFNFIIPGSSFYSGIESSSWLSTCVRRPKYIMCTGGEPSGYIPTYSTRNTASSESLSGNMWSNLSSWMPRREVPSQSTEESSRFPGRGRTLGAPQMETVSNNSSDSSLQARLLETPPGIDNTAAATMGSPVSQVTVASDEDIQKLLAMGFDKTQVEVAIAAADGDVNKDSEVNRVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZZ4</accession>
    <name>A0A118JZZ4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_021159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003370">
        <property type="protein sequence ID" value="KVI00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZZ4"/>
    <dbReference type="STRING" id="59895.A0A118JZZ4"/>
    <dbReference type="Gramene" id="KVI00598">
        <property type="protein sequence ID" value="KVI00598"/>
        <property type="gene ID" value="Ccrd_021159"/>
    </dbReference>
    <dbReference type="OMA" id="GNINWIG"/>
    <dbReference type="OrthoDB" id="5314306at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF10">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="415" mass="48315" checksum="2F6AFE5D39B0A35F" modified="2016-04-13" version="1">MASLIPDELIVEILSRLPSKSLLRFRSVCKSWLSLISSTEFRLMHFHNFNKPNPRHLLRRFELRENKEVYTVHLDDQHFTVDAEAPIKFPFKIVGPDIYCYKIIGCCNGVVCLCNANTTDEEVILWNPSVRRNITLVPPIFPNNYWYELILVLGFGYDTTSDDYKVVRVANDGLFFFARPHVEIYTVKTAVWRAVTFPDDLRCFSILPNQSQVFFNGSLHWIACDPMLEVSDYSIMTFDMSTELFGEIQLPNDLELESMTEVVVTVVEEFLGVIYSCRHSSSWWGSSTYVIWAMKEYKNPATWTKMHTMYYPDEDVGRALQVRSNGDLITVSNYGDVTIYNREMCHYVYTSSMGLMLADSIFFERYQESLALLDAEHDALDEERVEEGHDEGFDDEWLARYEATYLIPLFDEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K051</accession>
    <name>A0A118K051_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003307">
        <property type="protein sequence ID" value="KVI00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K051"/>
    <dbReference type="STRING" id="59895.A0A118K051"/>
    <dbReference type="Gramene" id="KVI00733">
        <property type="protein sequence ID" value="KVI00733"/>
        <property type="gene ID" value="Ccrd_021014"/>
    </dbReference>
    <dbReference type="OMA" id="KPIKIQH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000540">
        <property type="entry name" value="Serine/threonine-protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146:SF23">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="51505" checksum="22EA177A553C28C2" modified="2016-04-13" version="1">MGYLSCKAESTIAVHNPSKKSDKIHGNEDLIHKKIQHFDYSDLEAATNNFSDQKLLGRGSHGLVYKALLRNGRLVAVKKPSHQNNHHSAISAVPENEVENEIDILSKLHSPRLVNLVGFTNTPHQNRLLVVEFMSNGTLYDTLHLSQQPPNWGRRIRLAVQTAKAIEILHSSVPPVIHRDIKSANVLIDRNFNARLGDFGLALRCHVDDYRLLSTPPAGTMGYLDPGYVTPDNLSTKTDVFSFGILLLEIISGRKAIDVSHSPPSIVDWAIPLIRRGKLLSVFDPRIPPPKDPMVRKQLGVIAAKCVRSCRERRPSMNEIVESLSFLTKLVPLRSWNGLSNPCMMVENVGRPVEVVSSRPKTGGGVDEGKTLSNPRRVYSDLGFRNNLMDLMAGRVENEEDDTMKTQVHRRSRLKNEGSSFRSIVSGNKFERNRSAGETSANISTRRCYAVARSKSYAQTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K227</accession>
    <name>A0A118K227_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_018020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002335">
        <property type="protein sequence ID" value="KVI03675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K227"/>
    <dbReference type="STRING" id="59895.A0A118K227"/>
    <dbReference type="Gramene" id="KVI03675">
        <property type="protein sequence ID" value="KVI03675"/>
        <property type="gene ID" value="Ccrd_018020"/>
    </dbReference>
    <dbReference type="OMA" id="FMERESC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000740">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI03675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="411" mass="44427" checksum="F31D2DBBB6B93607" modified="2016-04-13" version="1">MGTGSSMNLDSTSHGIGEDHAGGQLYVSLKMENYSPRGDLVPHVYGSGPLVGSWDASKALPMERESTSMWELSFVVPPNHETLDFKFLLKSKNNNGPCIVEEGPIRQFMGGALQGVARLALFRLTAEEVLEYRVCITADRVSPFDLAASWRAYQENLEPSTVRDIPDVSINALPEGEENGSSTSLDLDLEQYVVPTPPTSLVYAANLTETPRCLQHGRGVTKGDGSEKGVGVSVDRPPTIKEREVVVQEKESDSPKVYYSPGMVESKSVGTFSVVQKQDGQKGLLVDRGVGSSRLNSMPAAAGAVAAAAVADQMLGPKEDMHLAIVLVGLPARGKTFTAAKLTRYLRWLGHDTKHFNVGKCADFFRGDNPEGMEARNEVAALAMDDMIAWMHEGGQAGFRSRISGLQKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2L2</accession>
    <name>A0A118K2L2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AWS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_017134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001998">
        <property type="protein sequence ID" value="KVI04548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2L2"/>
    <dbReference type="STRING" id="59895.A0A118K2L2"/>
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        <property type="protein sequence ID" value="KVI04548"/>
        <property type="gene ID" value="Ccrd_017134"/>
    </dbReference>
    <dbReference type="OMA" id="DIAICVC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="172"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVI04548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="567" mass="63243" checksum="91AE326C331D5768" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2X6</accession>
    <name>A0A118K2X6_CYNCS</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_016645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
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                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001891">
        <property type="protein sequence ID" value="KVI05040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="59895.A0A118K2X6"/>
    <dbReference type="Gramene" id="KVI05040">
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        <property type="gene ID" value="Ccrd_016645"/>
    </dbReference>
    <dbReference type="OMA" id="DDWASAV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell division"/>
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        <property type="project" value="EnsemblPlants"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
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            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI05040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="294" mass="32245" checksum="BC2DA975F476792A" modified="2016-04-13" version="1" fragment="single">AVADESEGRRPSTVAARFLTRFLICQFLNKPVFGKKQRSVFKYNNLCKFDALFAVTMVGRYSDDDEDETFYYRYASVAPQPPSSSSSDKTLSKSSSHRGGGSGSRSGGLAPSKSTVYVSNLDYSLTNSDLFTIFSTFGKVAKVTILRDRVTRESRGVAFVLFVARDDAIKAVKGISGKVLNSRTLTASIAADNGRAPEFIRRRVYKDKSRCYECGEGGHLSYECPKNQLGPRVPPQPSKRGRREGRGGSSGGYRRSKEEEWGGDDDETGGDEVFEDDNWASVVDNGADERLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K3Z3</accession>
    <name>A0A118K3Z3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_014939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001741">
        <property type="protein sequence ID" value="KVI06705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K3Z3"/>
    <dbReference type="STRING" id="59895.A0A118K3Z3"/>
    <dbReference type="Gramene" id="KVI06705">
        <property type="protein sequence ID" value="KVI06705"/>
        <property type="gene ID" value="Ccrd_014939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI06705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="153" mass="17582" checksum="DF8889F31789EB92" modified="2016-04-13" version="1" fragment="single">MEEEELRVDGLSMGDFDSNQKENSELASDFNAMDDKNNGFTQENQAEDSDAEEEYDDEEEEDAEETYSLRFEGETDPLALKEDDSFGVQAYECLEQPGHEYEALAAKKRKESLNYNHLGMPPIKKLRQEDYPGPSFEDLLAEITHGKRRKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K418</accession>
    <name>A0A118K418_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001590">
        <property type="protein sequence ID" value="KVI06825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K418"/>
    <dbReference type="STRING" id="59895.A0A118K418"/>
    <dbReference type="Gramene" id="KVI06825">
        <property type="protein sequence ID" value="KVI06825"/>
        <property type="gene ID" value="Ccrd_014820"/>
    </dbReference>
    <dbReference type="OMA" id="CKCGDFM"/>
    <dbReference type="OrthoDB" id="614712at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF7">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI06825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="160" mass="17940" checksum="CA5DCB8CAA96FB11" modified="2016-04-13" version="1">MKSRKDDKDFCYSLTLPLSSPSSSPSSSSSSISLSQILKMGFIQSSSFSPNSKTFFIVFLILTSSHAQGESNWKLIHKDIQMERRNLLIGSRPPRCEKGYCRNCGHCEAVQVPISPRFIRTTHQALGTTTRSIVDSRGDAISNYKPMCWKCKCGDFMFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K597</accession>
    <name>A0A118K597_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001092">
        <property type="protein sequence ID" value="KVI08728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K597"/>
    <dbReference type="STRING" id="59895.A0A118K597"/>
    <dbReference type="Gramene" id="KVI08728">
        <property type="protein sequence ID" value="KVI08728"/>
        <property type="gene ID" value="Ccrd_012898"/>
    </dbReference>
    <dbReference type="OMA" id="LERHMYM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="337" mass="38165" checksum="A7A7C76E49BDCE8D" modified="2016-04-13" version="1" fragment="single">YAKSPINLIISPRIYSTSFNSPTPSIYNRRKGLSGSTQMAEDPIIATDNSLKKLELERSDDTVSRFLGGLNHTIRKLVFRVISSGPIPQHIAFILDGNRRFAKKWKMTEGAGHKAGFLALMSVLKYCYEIGVKYVTVYAFSLDNFNRRPDEVQYVMDLMQEKIEGFLKELSLVNKYGVRVMFIGDLKRLYEPVRVAAEKAMAATAGNTKTYLLVCVAYTSSHEIPRAVYESCEEKNGVMNENGSVNGDVNTGNGSEVVVKMVDIEKHMYMAVAPDPDILVRSSGETRLSNFLLWQTTNCLLYSPKELWPEMGFWPLVSCILEFQKNYKYLEKKKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAP8</accession>
    <name>A0A124SAP8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAR1 DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_024417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005527">
        <property type="protein sequence ID" value="KVH88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAP8"/>
    <dbReference type="Gramene" id="KVH88192">
        <property type="protein sequence ID" value="KVH88192"/>
        <property type="gene ID" value="Ccrd_024417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="297" mass="34572" checksum="764409940930DDEC" modified="2016-04-13" version="1">MKNTDDFDTGLSSYNHVEGLTNQDIEGEIGLIEDVVSHGMDERAGYKYNNDMQDAKVENKYFVCNKSGFPLKKSFDSLIRHKHQREVRNSNTKRTRCTACVKFRLMKGTITYECYGFEEKDNHFLLRHNDIDFSRKARQMKILDQCFVHDTSISNIGSILSHKFQTSLRECYEYGGPMVVDYQNDKRDSDNFVGCDDAKVLVDLMTKKRISIQNYSEFGDVISFDATLCTNIHFMVFVSFTAVDNYNCIVVVGLTLVGHEHNPHHHHKYLAMHRWKDESLLAQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAW8</accession>
    <name>A0A124SAW8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_025345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005332">
        <property type="protein sequence ID" value="KVH88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAW8"/>
    <dbReference type="STRING" id="59895.A0A124SAW8"/>
    <dbReference type="Gramene" id="KVH88825">
        <property type="protein sequence ID" value="KVH88825"/>
        <property type="gene ID" value="Ccrd_025345"/>
    </dbReference>
    <dbReference type="OMA" id="SHDFNTI"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44991">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44991:SF1">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50480" checksum="2DDC18F15F57EF85" modified="2016-04-13" version="1">MVGWIHISLVVASAGIFLLLFLFFHCFCHTKQPEPVAGPPSIQNGISKLHHQDNAFNNKRRTNYYVSRRGLSSKPLFNWSDNPSLIADAVENGWSQFAFTDYASSLSVRSNRFLLGSCASSGDGSGGDAEEVEISWEVCQGSADFMQKIHLNSGLKKMASSTSSSMAAGSVIKSALPLPGPALGNSSPFPQEAYFEITILSICENENGIDSDGKARLNTGEGENIKLIQEHGEMHANCEESNDRTSVSKDTVEGKNEVFIMLSVGLTGGGSLPVKLPGSYPGSVGFNSDGSIYLDGVKLITELEIERWERNEKVIGCGYNPSQKKVFFTIDSKLVQEIHCKTEEYGTPLYPTLAANSDIMVLVNFGQSIFKYAPANSQRTQNPCFVGPMANSSSSGYEDSKEFFSMGRIDSQWLNRPTTRSGQYNLNVNKGKTKDYDEASEGDLFEIVLDSNSYRKSPGTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB42</accession>
    <name>A0A124SB42_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_008569</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB42"/>
    <dbReference type="STRING" id="59895.A0A124SB42"/>
    <dbReference type="Gramene" id="KVH89452">
        <property type="protein sequence ID" value="KVH89452"/>
        <property type="gene ID" value="Ccrd_008569"/>
    </dbReference>
    <dbReference type="OMA" id="ENCMELI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000217">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g53430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF72">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RFK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="252"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="517" mass="57327" checksum="DA98FA9F78885D38" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBI4</accession>
    <name>A0A124SBI4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_007231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBI4"/>
    <dbReference type="STRING" id="59895.A0A124SBI4"/>
    <dbReference type="Gramene" id="KVH90757">
        <property type="protein sequence ID" value="KVH90757"/>
        <property type="gene ID" value="Ccrd_007231"/>
    </dbReference>
    <dbReference type="OMA" id="FAMICFS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000048">
        <property type="entry name" value="High affinity nitrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000053">
        <property type="entry name" value="Nitrate transporter 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH90757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="399" mass="42436" checksum="4A2BB92C07AFFEE5" modified="2016-04-13" version="1" fragment="single">MPEIEGSPGTSMHGVTGREPVLAFSVASPMVPTDSTAKFDLPVDSEHKAKVFKLFSLAKPHMRTFHLSWLSFFTTFVSTFAAAPLVPIIRDNLNLTKSDIGNAGVASVSGSIFSRLVMGAVCDMLGPRYGCAFLIMLSAPTVFCMSFVEDASGYIAVRFMIGFSLATFVSCQYWMSTMFNSKIIGLVNGTAAGWGNMGGGATQLLMPVLFEIIKKAGATPFTAWRIAFFIPGWLNVIMGILVLTLGQDLPDGNLGALQKKGNVAKDKFGKLHLAGIVAAVFGMANIVARPFGGFTSDFMAKKWGMRGRLWNLWLLQTAGGIFCLCLGLVNSLPLAITFMILFSVGAQAACGATFGIIPFISRRSLGIISGMTGAGGNFGSGLTQLIFFANSQFSTAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCJ8</accession>
    <name>A0A124SCJ8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxiredoxin Q, chloroplastic</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Thioredoxin-dependent peroxiredoxin Q</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_003902</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004577">
        <property type="protein sequence ID" value="KVH94045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCJ8"/>
    <dbReference type="STRING" id="59895.A0A124SCJ8"/>
    <dbReference type="Gramene" id="KVH94045">
        <property type="protein sequence ID" value="KVH94045"/>
        <property type="gene ID" value="Ccrd_003902"/>
    </dbReference>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009543">
        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000122">
        <property type="entry name" value="Peroxiredoxin Q chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="69"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH94045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="215" mass="23695" checksum="59CFDCB9452FEA13" modified="2016-04-13" version="1">MVSLVKQPLLSLLPSCNATTQSPKQYPFANTPFKSSQSHFHGLKLTFSNPSSSLTPLISKTSVIVSAKVNKGSVPPSFTLKDQDGRNVSLSKFKGKPVVVYFYPADETPGCTKQACAFRDSYEKFKKAGAEVVGISGDDGVSHKAFAKKYRLPYTLLSDEDNKIRKEWGVPSDLFGTLPGRQTYVLDKNGVVQLIYNNQFQPEKHIDETLKSAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SED5</accession>
    <name>A0A124SED5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_022007</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01003414">
        <property type="protein sequence ID" value="KVH99757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SED5"/>
    <dbReference type="Gramene" id="KVH99757">
        <property type="protein sequence ID" value="KVH99757"/>
        <property type="gene ID" value="Ccrd_022007"/>
    </dbReference>
    <dbReference type="OMA" id="MSSVDIY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <sequence length="1758" mass="189505" checksum="0A822442343B27A8" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFE2</accession>
    <name>A0A124SFE2_CYNCS</name>
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        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">Ccrd_018750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-aspartate + O2 = iminosuccinate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
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        </reaction>
    </comment>
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        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Plastid</location>
            <location evidence="11">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:L-aspartate oxidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:NAD+ biosynthetic process"/>
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        <property type="entry name" value="L-ASPARTATE OXIDASE"/>
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    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="12">
        <location>
            <begin position="80"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="13">
        <location>
            <begin position="520"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI02953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="639" mass="71063" checksum="2A5358CF23208D8D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFK4</accession>
    <name>A0A124SFK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_018157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002345">
        <property type="protein sequence ID" value="KVI03526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SFK4"/>
    <dbReference type="Gramene" id="KVI03526">
        <property type="protein sequence ID" value="KVI03526"/>
        <property type="gene ID" value="Ccrd_018157"/>
    </dbReference>
    <dbReference type="OMA" id="XYLANNI"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000545">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI03526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="365" mass="42334" checksum="A6988D62310A5B20" modified="2016-04-13" version="1">MEKYQRIREIGRGSYGVVFKALNTENGELVAVKKMTDRKYYSSKECMNLREVRSLCKMRNHPNIVKLKEAVVQNNILFLVFEYMECSLWHRMRHRTNPFSEIEIRNLCFQIFQGLAYMHNEAGYFHRDLKPDNLLVSKDVIKIADLGQAREINGEPPYTDYITTRWXRAPEVLLHARAHDSSVDMWAMGAIMVELFTLRPLFDGSSATEVMRKICSVIGTPTETTWSLGXYLANNINYRFPEFPGVDLSSLIPCASPEAINLISTLLSWSPCARPTAKEALEHPFFYGCYYHIPHPQFDCVTWSRMMRDRALPLVFKMAMRREMLKQITRRLESCLGGLKGSESPREDLVHHLPEFLFEFDGEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFK6</accession>
    <name>A0A124SFK6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phox homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_018162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002345">
        <property type="protein sequence ID" value="KVI03538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFK6"/>
    <dbReference type="STRING" id="59895.A0A124SFK6"/>
    <dbReference type="Gramene" id="KVI03538">
        <property type="protein sequence ID" value="KVI03538"/>
        <property type="gene ID" value="Ccrd_018162"/>
    </dbReference>
    <dbReference type="OMA" id="LWETFLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000028">
        <property type="entry name" value="sorting nexin 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI03538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="41032" checksum="8B2BF9FE103A0E73" modified="2016-04-13" version="1">MITTQRSATGGGGLQSPRSPSSQPPYLTVSVTDPAKMGNGVQAYISYKVITKTNFPDYQGPEKIVIRRYTDFVWLRDRLFEKYKGIFIPPLPEKSTVEKFRFSAEFIEMRRQALDTFVNRIAMHHELQQSEDLRTFLQADELTMERARSQDTGIFKRKPSDLMQIFRDVQSKVSDVVLGKEKPVEETNPEYEKLKRYIFELEDHLAEAQKHAYRLAHHLLMNFEEPLKDYVRAVQSIKGTIAERANAFRQQVELAETIKLKEIDLNKFRLTRSEKMSEAEHEYEELKADGEEATKRFETIVRLMNEEIVRFQDQKTQDMGLAFHEFAKGQARLANGIADAWRSLLPKLEALSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SGP6</accession>
    <name>A0A124SGP6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_014603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001528">
        <property type="protein sequence ID" value="KVI07038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SGP6"/>
    <dbReference type="STRING" id="59895.A0A124SGP6"/>
    <dbReference type="Gramene" id="KVI07038">
        <property type="protein sequence ID" value="KVI07038"/>
        <property type="gene ID" value="Ccrd_014603"/>
    </dbReference>
    <dbReference type="OMA" id="PLATENW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF323">
        <property type="entry name" value="AMINO ACID TRANSPORTER AVT6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="213"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="418"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI07038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="814" mass="89056" checksum="C6F591F090F6C515" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SH73</accession>
    <name>A0A124SH73_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanosine nucleotide diphosphate dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001099">
        <property type="protein sequence ID" value="KVI08668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SH73"/>
    <dbReference type="STRING" id="59895.A0A124SH73"/>
    <dbReference type="Gramene" id="KVI08668">
        <property type="protein sequence ID" value="KVI08668"/>
        <property type="gene ID" value="Ccrd_012967"/>
    </dbReference>
    <dbReference type="OMA" id="GRICKVP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000002">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF28">
        <property type="entry name" value="GUANOSINE NUCLEOTIDE DIPHOSPHATE DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI08668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="448" mass="49831" checksum="FD5A1420684E9603" modified="2016-04-13" version="1">MDEEYDVIVLGTGLKECILSGLLSVDGLKVLHMDRNDYYGGESTSLNLNQLWKRFKGSDSPPAELGASRDYNVDMIPKACLFMMANGALVRVLIHTSVTKYLNFKAVDGSFVYNKGKIHKVPATDVEALKSPLMGLFEKRRARKFFIYVQDYDDNDPKSHEGLDLTKVPARDVLSKKYGLDDNTIDFIGHALALYRDDKYLDQPAVDFIKKVKLYAESLARFAGGSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFQDGKVFGVTSEGETAKCKKVVCDPSYLPDKVKKVGKVARAICIMSHPIPNTNDAHSTQVILPQKQLGRKSDMYLFCCSYSHNVAPKGKYIAFVTTEAETDSPEQELKPGIELLGPVDQIFFDAYDRYEPTNQGAEDHCFISTSYDATTHFETTVQDVIAMYSQITGKTLDLSVDLSAASASNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SHS6</accession>
    <name>A0A124SHS6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_011142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the early nodulin-like (ENODL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001019">
        <property type="protein sequence ID" value="KVI10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SHS6"/>
    <dbReference type="STRING" id="59895.A0A124SHS6"/>
    <dbReference type="Gramene" id="KVI10471">
        <property type="protein sequence ID" value="KVI10471"/>
        <property type="gene ID" value="Ccrd_011142"/>
    </dbReference>
    <dbReference type="OMA" id="KSHYESC"/>
    <dbReference type="OrthoDB" id="2015640at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11019">
        <property type="entry name" value="OsENODL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000010">
        <property type="entry name" value="Early nodulin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041846">
        <property type="entry name" value="ENL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF375">
        <property type="entry name" value="PHYTOCYANIN DOMAIN, CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007176265" evidence="11">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="12">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="260" mass="26719" checksum="0C01238C3891D1CF" modified="2016-04-13" version="1">MESFHKTLCIFFTFFFALLSSSRAYTFNVGGRDGWTLHPSENYNQWSGRLRFIVNDALHFKYNGGSDSVLEVNNGDYDNCNTKNPITKLAGGDSYFTLNRSGPFYFISGNKSNCDQGQKLNVVVISPKTKSSPPPAGVASPPTSFSPIPSEFPISAPPQPGTTIPASPASSPGGTGSGGSSSPASSPDGSDSFSPAGSPASSPGVSDSSSPAGSPASSPIGNPADINAPPPSGSSSEKLAASAILTFPLAIIIFGFGSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SI52</accession>
    <name>A0A124SI52_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_009966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000067">
        <property type="protein sequence ID" value="KVI11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SI52"/>
    <dbReference type="STRING" id="59895.A0A124SI52"/>
    <dbReference type="Gramene" id="KVI11627">
        <property type="protein sequence ID" value="KVI11627"/>
        <property type="gene ID" value="Ccrd_009966"/>
    </dbReference>
    <dbReference type="OMA" id="VPLQTMY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="232"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="401" mass="44608" checksum="67CFC5BD387537AC" modified="2016-04-13" version="1">MFTSACTVAGGQHSHYLSSYCVGNLCSHRRNFPIMISSISKIRSHSFTVNRNSVAAAAAVSSSSSTRNTNNSINDGSSSFTWDDVFQISESRHVSSDLGGFFQKINLCNRGWDRRADFIPFVIEDQIVGYIHNGFLNHLSKFKDVFTCIKDNTYGSQSGHVTLQSALKTPEYRTEALENVVKCLGEEVIPGIRNEVLTYQNNGPLFPVTSSYGQRTYFSLERAAAPYFGIKAYGVHMNGYVERDGQKYLWIGKRSETKPTYPGMLDHLVAGGLPHGISCGENLVKECEEEAGIPNSISSRAIPVGAVSYMDIDGYRFKRDVLFCYDLKLPESFIPSNQDGEVGSFKLLPITLVADAIRSTQFFKANCNLVIIDFLFRHGYIKPEYLGYLKLLQSLRSGDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5C4</accession>
    <name>A0A103D5C4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01012818">
        <property type="protein sequence ID" value="KVD98097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5C4"/>
    <dbReference type="Gramene" id="KVD98097">
        <property type="protein sequence ID" value="KVD98097"/>
        <property type="gene ID" value="Ccrd_024312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053106">
        <property type="entry name" value="Plant_Male-Germline_Reg_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47996:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVD98097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="115" mass="13667" checksum="4D26935888EB0AD0" modified="2016-04-13" version="1">MEKQILFDLQGKYGNKWAKISTYLPGRSVYHVKNVWYNHQTKMARFYKGNTECLKFGSSPDEKKKKERKRKKKKERKRKKNKEKGTAGRKKVQQGGYILVIQETNYDASRAQYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103K592</accession>
    <name>A0A103K592_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant DMP1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009398">
        <property type="protein sequence ID" value="KVF44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103K592"/>
    <dbReference type="STRING" id="59895.A0A103K592"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007770">
        <property type="entry name" value="DMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621:SF5">
        <property type="entry name" value="PROTEIN DMP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621">
        <property type="entry name" value="PROTEIN DMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05078">
        <property type="entry name" value="DUF679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVF44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="122" mass="13829" checksum="FD5D1F32D9B70660" modified="2016-04-13" version="1" fragment="single">FIDPSDGKLYYGIDTFKGFYIFDYGTRPRCCDQEDEDEEGLKRFKISGIDIGHAFLSLIVFLVFAISDTDVQSLLFPESEANMNVLLMNLPLSVGVLASFRFTIFPTTHRGLGYTDFPLHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103L5L1</accession>
    <name>A0A103L5L1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteinase inhibitor I13, potato inhibitor I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_026716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01009146">
        <property type="protein sequence ID" value="KVF69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103L5L1"/>
    <dbReference type="Gramene" id="KVF69647">
        <property type="protein sequence ID" value="KVF69647"/>
        <property type="gene ID" value="Ccrd_026716"/>
    </dbReference>
    <dbReference type="OMA" id="XTIEREN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091:SF109">
        <property type="entry name" value="PROTEINASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00285">
        <property type="entry name" value="POTATO_INHIBITOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVF69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="11338" checksum="AE68608078463B52" modified="2016-04-13" version="1">MTDCAGKSSWPELVGRTGEAAXVIIERENPLVDAIVLLDGKRSWPEVVGRRGEDAVXTIERENPRVDAFVILDGTSVIGDFRCDRVRVRVNSRGIVVRTPEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103QIH4</accession>
    <name>A0A103QIH4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01008072">
        <property type="protein sequence ID" value="KVG50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103QIH4"/>
    <dbReference type="Gramene" id="KVG50054">
        <property type="protein sequence ID" value="KVG50054"/>
        <property type="gene ID" value="Ccrd_026388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835:SF90">
        <property type="entry name" value="AMINOTRANSFERASE-LIKE PLANT MOBILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34835">
        <property type="entry name" value="OS07G0283600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVG50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="163" mass="18074" checksum="B25426E467F13D44" modified="2016-04-13" version="1" fragment="single">NAYFSKDVIRNNEVPNRRLTGSDQGNGLCVSFGYDDTAAMNITMNASVIPITVKSIYDVLGLPMGGVDLNSVDPSSAIDDIITAWRKQFSKDRMRLKDVMTVVQKSGDSGAMFKISFLVIVINTLAECSRVGVCNLHFLSRIRSLNMIPHINWCKYIFDCIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103S159</accession>
    <name>A0A103S159_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ent-kaurene synthase</fullName>
            <ecNumber evidence="5">4.2.3.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22220"/>
            <dbReference type="ChEBI" id="CHEBI:15415"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58553"/>
            <dbReference type="EC" id="4.2.3.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22221"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.19" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01007653">
        <property type="protein sequence ID" value="KVG77632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103S159"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009899">
        <property type="term" value="F:ent-kaurene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033331">
        <property type="term" value="P:ent-kaurene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.130:FF:000002">
        <property type="entry name" value="Ent-copalyl diphosphate synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF4">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01014">
        <property type="entry name" value="Terpene_Cyclase_Like_1_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01605">
        <property type="entry name" value="Terpene_Cyclase_Like_1_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="7">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG77632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124381" checksum="0598B0C0712651E3" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103S986</accession>
    <name>A0A103S986_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007574">
        <property type="protein sequence ID" value="KVG81972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103S986"/>
    <dbReference type="Gramene" id="KVG81972">
        <property type="protein sequence ID" value="KVG81972"/>
        <property type="gene ID" value="Ccrd_026176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043459">
        <property type="entry name" value="NFD6/NOXY2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156">
        <property type="entry name" value="OS02G0230000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156:SF43">
        <property type="entry name" value="OS02G0273900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG81972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15882" checksum="857C94555FCBDE0A" modified="2016-04-13" version="1">MASSRAVSRLCSRLHSLSPKFTTKRSPSLSLDSSSFVKSTSNPQVSSSSRRFSRLPVELSALITMMPLHSAIASACLKSGLSLESESWGLVPQEISMHHVSTNYDCMKWIKAFQCLYDDTVPEADVRMSRNTSRTSSNFRNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SPX1</accession>
    <name>A0A103SPX1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_026118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007456">
        <property type="protein sequence ID" value="KVG90338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SPX1"/>
    <dbReference type="STRING" id="59895.A0A103SPX1"/>
    <dbReference type="Gramene" id="KVG90338">
        <property type="protein sequence ID" value="KVG90338"/>
        <property type="gene ID" value="Ccrd_026118"/>
    </dbReference>
    <dbReference type="OMA" id="DCKSNIG"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF821">
        <property type="entry name" value="AGAMOUS-LIKE 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVG90338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="197" mass="22765" checksum="12F327AC8268EF29" modified="2016-04-13" version="1">MARLPSKDRKKIQLKRIENEKERAVTLSKRCNDIFKKANKLATLCHIQIAIILFSIIGKRLSFGSPNVQSVVNKFLNPNQLDQQPNDFINMAVNSNHESKLQDFNKEFDEVNEHLANEKKQGQMLDEYIKRLLGGKTYKEYVAIRGYYGFMQIKFKMEELQRNKECTLVAVCGPSSSNDENEAYLSKIGVPKDYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103T1R8</accession>
    <name>A0A103T1R8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007251">
        <property type="protein sequence ID" value="KVH02537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103T1R8"/>
    <dbReference type="Gramene" id="KVH02537">
        <property type="protein sequence ID" value="KVH02537"/>
        <property type="gene ID" value="Ccrd_026005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH02537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="68" mass="8071" checksum="CCCE5C7A4D27C076" modified="2016-04-13" version="1">MQKNVELPVRWWRRGEGRRSIGGWGRRRIPELVLQVLLCTKNLNIALWKSCLEYIFDRQACRLSSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103USY1</accession>
    <name>A0A103USY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Triosephosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_025793</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + H2O = (2R)-3-phosphoglycerate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LEKV01006874">
        <property type="protein sequence ID" value="KVH40997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103USY1"/>
    <dbReference type="STRING" id="59895.A0A103USY1"/>
    <dbReference type="Gramene" id="KVH40997">
        <property type="protein sequence ID" value="KVH40997"/>
        <property type="gene ID" value="Ccrd_025793"/>
    </dbReference>
    <dbReference type="OMA" id="NLVCRVN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008886">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07082">
        <property type="entry name" value="ALDH_F11_NP-GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000016">
        <property type="entry name" value="NADP-dependent glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000013">
        <property type="entry name" value="NADP-dependent glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051020">
        <property type="entry name" value="ALDH-related_metabolic_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH40997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="482" mass="51587" checksum="CFB4D9777BA67461" modified="2016-04-13" version="1">MAGTGVFEDIIEGDVFKYYTDGEWKKSASGKSVAIINPTTRTTQYKVQACTQEEVNKVMESAKIAQKQWAKTPLWKRAELLHKAAAILKEHKAPIAECLVVRSGDLISYCAEEGVRILGEGKFLVSDSFPGNERTKYCLSSKIPLGVVLAIPPFNYPVNLAVSKIGPALIAGNSLVLKPPTQGAVACLHMVQCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGGDTGVAISKKAGMVPLQMELGGKDACIVLEDADLDLVAANIIKGGFSYSGQRCTAVKVVLVMESVADALVEKVNAKVAKLKVGPPEDNCDITPVVSESSANFIEGLAKDAKAKGATFCQEYKREGNLVWPLLLDNVRPDMRIAWEEPFGPIVPVIRINSIEEGIHHCNASNFGLQGCVFTKDINKAILISDAMETGTVQINSAPARGPDHFPFQGLKDSGIGSQGITNSINMMTKIKSTVINLPTPSYTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UVK9</accession>
    <name>A0A103UVK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L18/L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006853">
        <property type="protein sequence ID" value="KVH42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103UVK9"/>
    <dbReference type="Gramene" id="KVH42608">
        <property type="protein sequence ID" value="KVH42608"/>
        <property type="gene ID" value="Ccrd_025781"/>
    </dbReference>
    <dbReference type="OMA" id="NEVICKF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF7">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="422" mass="47720" checksum="3D9B70E0D184E857" modified="2016-04-13" version="1">MLGKRLFVVSGSILQNFYIRDYNLNFEYLKVETKFEISILRAVHNRTEAVCDSLLRSKVETTSSCYDHSLHHSPLFSKIGDQSNDYKIDIVDDETWQVSTGFANAWKDATAPSLVTNASHAQVANDTPRNSLDRDSKEYEEYNIDFHRRKSSKRKTDQRESKAKENPNSTSGNMVENVSKRKDEIRESKXNGNPRNNYGISMFDEMEKPEGSFIEKKQRVPTFNQLTAPYHEPFCLDIYISKASIRACIVHRATSKVVAVAHSISKDMKFDLGSTRNAAACAAVGKVLAQRAFADDIHNVVYTPRKGEKLEGKLQIVLQSVINDGVRVKVKIKKTKLNKSAAFSAVKSSNFITQHETKVAGQGPDCCVSDNLVSSLTSSYNEVICKFDQWQKQLGLPTSQEKKRFVVELFQPQTFLKLNQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103WQ89</accession>
    <name>A0A103WQ89_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_025537</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01006509">
        <property type="protein sequence ID" value="KVH76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103WQ89"/>
    <dbReference type="STRING" id="59895.A0A103WQ89"/>
    <dbReference type="Gramene" id="KVH76412">
        <property type="protein sequence ID" value="KVH76412"/>
        <property type="gene ID" value="Ccrd_025537"/>
    </dbReference>
    <dbReference type="OMA" id="RMDGQYG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000258">
        <property type="entry name" value="Probable serine/threonine-protein kinase PBL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="412" mass="46300" checksum="11969579C1DBA50F" modified="2016-04-13" version="1">MGTCFSSEYDEHHSFQTKPGEIQPSPSKEALKIPPKQSSLESPNIKSPSSVVVITKNVKDLRQNPGYSNLDIFTYDEMRMATKLFRPDQVLGEGGFGVVYKGVIDENVRPGYAKTQVAVKELDPEGIQGDREWLAEVNYLGQLQHPNLVKLIGYCCEEDHRLLVYEYMASGSLEKHLFRRVCATLTWSRRMKIALDAAKGLAFLHDAERPIIYRDFKTSNILLDADFNAKLSDFGLAKDGPMGDQTHVSTRVMGTYGYAAPEYVMTGHLTARSDIYGFGVVLLEMLIGRRAMDKSRPSREHNLVEWARPLLVHNKKLVRILDPRMEGQYSSKTAIKVANLAYQCLSQNPKGRPIMSQVVDTLESIQTCENGQEEALFQSGCGSVTLFEAPKKNENQVKEGDRQIKSPKETKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBM7</accession>
    <name>A0A103XBM7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_024978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005877">
        <property type="protein sequence ID" value="KVH87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBM7"/>
    <dbReference type="STRING" id="59895.A0A103XBM7"/>
    <dbReference type="Gramene" id="KVH87738">
        <property type="protein sequence ID" value="KVH87738"/>
        <property type="gene ID" value="Ccrd_024978"/>
    </dbReference>
    <dbReference type="OMA" id="AHGEMEI"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22464">
        <property type="entry name" value="KH-I_AtC3H36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF184">
        <property type="entry name" value="CCCH-TYPE ZN-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="29699" checksum="498D592A61733D4B" modified="2016-04-13" version="1">MDFGGRKRGRQDGGWNGAPKRARDEMESFTPGVGSKSKPCTKFFSTSGCPFGEGCHFLHYVPGGYHAPSPLTNMGGPLGRKSQMQQPFTDGLAPAVKNKLCNKINTPEGCKFGDKCRFAHSEAEIGGRPSFPGYENQRGPMNYGGGGYQASPPGLAGANFGQSATAKISIDASLAGAVIGKGGVNSKQICRITGVKLAIRDHETDENQKNIELEGSFDQIKQASAMVREVIMNLGGGNGGARKGGGGGNNFKTKMCENFGKGLCTFGERCHFAHGPNELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBQ6</accession>
    <name>A0A103XBQ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S10, serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_024934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005847">
        <property type="protein sequence ID" value="KVH87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVH87783">
        <property type="protein sequence ID" value="KVH87783"/>
        <property type="gene ID" value="Ccrd_024934"/>
    </dbReference>
    <dbReference type="OMA" id="CNLDMKY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF382">
        <property type="entry name" value="PEPTIDASE S10, SERINE CARBOXYPEPTIDASE, ALPHA_BETA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="467" mass="52755" checksum="4997A5437AAA6184" modified="2016-04-13" version="1" fragment="single">IYIHIHSTIKPITILLSYPPCQNKVNTHPKAHMMHTVSSLIPIYVGFLVWATSTTLIASQTIVKSLPGYPGPLPFKLETGYIGVGEDEAVQLFYYFVESEGNPDEDPLIIWLAGGPGPMQIRYGNYMDNVPALQLDPNSWTKFVKNHPRFLKNPMYVTGISYSGIIIPIITEELYKGNEEGLEPIVNIQGYMGGNPLTDKTGDINSRLEYAYRVALISQELYEATQNDCQGDYAEANSNELQCMSRIDEVNKRVGDINIQQILDPDCDPATNLVRSGNPIISGNRKSLRAANPIKMLPALSLHKDTFCRGDYYNYATLWANDENVMEALNVRKGTVKEWLLCNLDMKYNYGEPSMPLYEFNVKSSVVYHEKLSKRNCRALIFSGDHDMMVPHVGTRNWINSLNLTITESNWXAWYSNGQTAGYKTTYARDNYSLVFATVKGAGHTAPEFKPEECFQMVKRWFANKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCR9</accession>
    <name>A0A103XCR9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA/RNA helicase, DEAD/DEAH box type, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005422">
        <property type="protein sequence ID" value="KVH88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XCR9"/>
    <dbReference type="Gramene" id="KVH88388">
        <property type="protein sequence ID" value="KVH88388"/>
        <property type="gene ID" value="Ccrd_023935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="136"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="674"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1207"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1456" mass="160901" checksum="D39B81576E8CEE11" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCV5</accession>
    <name>A0A103XCV5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeate O-methyltransferase (COMT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_023910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005420">
        <property type="protein sequence ID" value="KVH88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCV5"/>
    <dbReference type="STRING" id="59895.A0A103XCV5"/>
    <dbReference type="Gramene" id="KVH88410">
        <property type="protein sequence ID" value="KVH88410"/>
        <property type="gene ID" value="Ccrd_023910"/>
    </dbReference>
    <dbReference type="OMA" id="LHDMIVY"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000357">
        <property type="entry name" value="Caffeic acid 3-O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000061">
        <property type="entry name" value="Caffeic acid O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="132"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="355" mass="38783" checksum="41C172CBCF99D078" modified="2016-04-13" version="1">MASQNQQEEEAFLFAMQLASASVLPMVLKSAIDLDLLETIAKAGPGAYVSPADLAAQLPKADNPEAAVMLDRICRLLASYSVLSCSLKKVGDDVERLYGLAPVCKFLVKNEDGVSMAPLLLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMSAFEYHGKDPRFNKVFNSGMFNHSTMTMKKILDVYDGFNGVSSLVDVGGGTGASLSMILSKHPSIKGINFDLPHVIEDATTYPGIEHVGGDMFKSVPEGDAIFMKWICHDWSDAHCVKFLKNCYKALPENGKVIVAECILPETPDSSLATQNVVHIDVIMLAHNPGGKERTQKEFEALAKSAGFKGFRKACCALNTWVMEFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XD69</accession>
    <name>A0A103XD69_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_026457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005368">
        <property type="protein sequence ID" value="KVH88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XD69"/>
    <dbReference type="STRING" id="59895.A0A103XD69"/>
    <dbReference type="Gramene" id="KVH88573">
        <property type="protein sequence ID" value="KVH88573"/>
        <property type="gene ID" value="Ccrd_026457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14938" checksum="89FE10BAEF4C46B3" modified="2016-04-13" version="1">MVKFLPILLLSTIKTSNSAPRRLFSSLKLVRSKLAFLQSYNFAQMDDFRLQIHGSQDDCPELKEHLKSNPCFRGERGNAFTVHHYAGEIFASNMRSQPEKLVASSLNISGGVDSQKLSVMSKFKVASLKTIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XEI5</accession>
    <name>A0A103XEI5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005291">
        <property type="protein sequence ID" value="KVH89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XEI5"/>
    <dbReference type="Gramene" id="KVH89208">
        <property type="protein sequence ID" value="KVH89208"/>
        <property type="gene ID" value="Ccrd_008804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="87" mass="10049" checksum="4C287340A34CFFE2" modified="2016-04-13" version="1">MLTDETKCCILEWPQHFYIIDGIAIDVGGNVDNEVEDDQKFENHMDEDVVFESVETEKLISNEVMADNIVYEEEEMEDTGELVDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XET6</accession>
    <name>A0A103XET6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_008553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005210">
        <property type="protein sequence ID" value="KVH89443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XET6"/>
    <dbReference type="STRING" id="59895.A0A103XET6"/>
    <dbReference type="Gramene" id="KVH89443">
        <property type="protein sequence ID" value="KVH89443"/>
        <property type="gene ID" value="Ccrd_008553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296:SF1">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH89443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="126" mass="14121" checksum="34FF5D1D5113D6F7" modified="2016-04-13" version="1">MASLKVYEPWWCWSSLAVLISNESIIPFLSRNDPESSNVVHCFNPAFVHAIAVPEVDMLDKFDKICFVARGDGVVDVINIKSDFSTAKSNGFRNREKVNWLCTIPTDSENLVVCDTSKVAKFYTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XF17</accession>
    <name>A0A103XF17_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MOR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein GEM1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein MICROTUBULE ORGANIZATION 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_008447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005198">
        <property type="protein sequence ID" value="KVH89565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103XF17"/>
    <dbReference type="Gramene" id="KVH89565">
        <property type="protein sequence ID" value="KVH89565"/>
        <property type="gene ID" value="Ccrd_008447"/>
    </dbReference>
    <dbReference type="OMA" id="NWKERKE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000121">
        <property type="entry name" value="Protein MOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000137">
        <property type="entry name" value="Protein MOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000155">
        <property type="entry name" value="Protein MOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="274"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="446"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="576"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="818"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1672"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1715"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1750"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1681"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH89565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1810" mass="199200" checksum="1CC29116E5677EA1" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGH2</accession>
    <name>A0A103XGH2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-rich protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005110">
        <property type="protein sequence ID" value="KVH90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGH2"/>
    <dbReference type="STRING" id="59895.A0A103XGH2"/>
    <dbReference type="Gramene" id="KVH90276">
        <property type="protein sequence ID" value="KVH90276"/>
        <property type="gene ID" value="Ccrd_007736"/>
    </dbReference>
    <dbReference type="OMA" id="FRFAMAF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132">
        <property type="entry name" value="OSJNBB0118P14.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132:SF53">
        <property type="entry name" value="SERINE-RICH PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32159" checksum="3EAA8F6A45A1CF52" modified="2016-04-13" version="1">MGTSSRKSNAPVMPLTSTFHRSSSPSGRFGVHSSAFAAEVSSPFASSTSSSFYSSPSPSHVYGRPSSPTRVNLHGLAPVTSSSVRFSLASRSGSPNRSMAMSSRDQVVRKQNAGNPLKNLPKKTCMCSPTTHPGSFRCSLHKNYNTSHGMTYSPNRLNARRSAMTNSLVRIGTVEGGDLVKRALAALIRPSSHQQRRRSAFEPRPSHLPALVLGFWRRLQFVIRFRVRPVMFRAVHQNPCYVPLSAVTFRYPSPFTVLFAVIFEEQAAGYHGSSGGICLSCKKIEVRDGSETIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XIV8</accession>
    <name>A0A103XIV8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IQ motif, EF-hand binding site-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_006490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004942">
        <property type="protein sequence ID" value="KVH91487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XIV8"/>
    <dbReference type="STRING" id="59895.A0A103XIV8"/>
    <dbReference type="Gramene" id="KVH91487">
        <property type="protein sequence ID" value="KVH91487"/>
        <property type="gene ID" value="Ccrd_006490"/>
    </dbReference>
    <dbReference type="OMA" id="CATKTSI"/>
    <dbReference type="OrthoDB" id="654277at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH91487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21983" checksum="AF0E06C4D8C0B41C" modified="2016-04-13" version="1">MLTFAYLLQWQAGSRQQTSPSGFGPDKTNWGWNWLERWMAVRPWENRFLDINTRDGLKIQENGSAKQEQEQEPNIRNQLKSAGKKSIASNLQLEFPNEKMGQSHSDGSGSDPIKSTSMQEAPATVCIDPTSNAFLADSVGELRLRPGVGSRSHSNPRERSSILGNQGKKRQSLPSSGKTGQGVGSHMARQPGKCATKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJU1</accession>
    <name>A0A103XJU1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_005928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004869">
        <property type="protein sequence ID" value="KVH92042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJU1"/>
    <dbReference type="Gramene" id="KVH92042">
        <property type="protein sequence ID" value="KVH92042"/>
        <property type="gene ID" value="Ccrd_005928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH92042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="298" mass="34949" checksum="0A9F9CD398118E33" modified="2016-04-13" version="1">MDGSYREVLSSRSSVVERYSGNNLFQSMLGFEIALEKQHREQRRLDYHTRTTLPKWLTYSKLERHACEGCLDMFNEGVNADEEVDTYLFEHLDKRDEKIAEYKVVRHLKESTIVCSCNHIGRHGYLCRHVFQVLLNADVESILEKYILRRWRRDLMPIELQNSRQRIYDVGEDQRRIINDIYDAFDDVLDILRDAKEKLESFVATIKELRDDLAKERTYEPSMKRKERGIEQILGFLRTDNIGIHPATGIRNKSCGTSKRLIVAVEKTVVKSFRPKRMCSGCKLLSNHDICNCLAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XP93</accession>
    <name>A0A103XP93_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_003669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004559">
        <property type="protein sequence ID" value="KVH94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XP93"/>
    <dbReference type="STRING" id="59895.A0A103XP93"/>
    <dbReference type="Gramene" id="KVH94303">
        <property type="protein sequence ID" value="KVH94303"/>
        <property type="gene ID" value="Ccrd_003669"/>
    </dbReference>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="353" mass="39331" checksum="A8EF99121A2108EA" modified="2016-04-13" version="1">MALLMEKGAEPQTEKELADLDAIAALKESAAIELKEEGNKYVKMGKKHYSEAINCYTRAINQNALSDTETSIIFSNRAHVNLLLGNYGRALSDSEEAMKLSPTNVKAFYRAAKASLSLNKLVEAKTFCENGLDQNPDNEELKKLLKQIDSQISEHQQHEAQVSKALTSAKGLVSAIEDRALNIGKAMFQELTGLKKPILDKDHILHWPVLLLYAEVMSSDFIEDFCETDISAPLPWDKENAYTRDAIELYYEAGSGVRLSKREIISTFLQGTVASHLESFGDDEIDGVKSSPKGISSIGEGRSKWVKVNERRTLHAVLKEPNLIIPGIPVFFVVSKRSSFYKEFKSGNWSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQ00</accession>
    <name>A0A103XQ00_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox KN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_003148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/BELL homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQ00"/>
    <dbReference type="STRING" id="59895.A0A103XQ00"/>
    <dbReference type="Gramene" id="KVH94770">
        <property type="protein sequence ID" value="KVH94770"/>
        <property type="gene ID" value="Ccrd_003148"/>
    </dbReference>
    <dbReference type="OMA" id="CSTGQRH"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000117">
        <property type="entry name" value="BEL1-like homeodomain protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006563">
        <property type="entry name" value="POX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07526">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00574">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="323"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="325"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH94770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="529" mass="59998" checksum="F396E2872694D3F6" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XRY6</accession>
    <name>A0A103XRY6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_002163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004377">
        <property type="protein sequence ID" value="KVH95779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XRY6"/>
    <dbReference type="STRING" id="59895.A0A103XRY6"/>
    <dbReference type="Gramene" id="KVH95779">
        <property type="protein sequence ID" value="KVH95779"/>
        <property type="gene ID" value="Ccrd_002163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH95779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="143" mass="15698" checksum="1BBCB6F17EACCE02" modified="2016-04-13" version="1">MKAQAFALTTWSNSKLGTGKPDLATIEPNQSGLNHSPAILMPSLESQARVTKPGDNPTPFAAYKQVEIEKMSTSSLRSMLAQAAVRGVTEARAKIFGHVLNPTGQRSAHKILRKKFIGEKVASWYPKDIEKEDPLVVARKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XS60</accession>
    <name>A0A103XS60_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial</fullName>
            <ecNumber evidence="5">1.6.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">External alternative NADH dehydrogenase NDB1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">NADH:ubiquinone reductase (non-electrogenic) NDB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ccrd_002021</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="5"/>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XS60"/>
    <dbReference type="STRING" id="59895.A0A103XS60"/>
    <dbReference type="Gramene" id="KVH95901">
        <property type="protein sequence ID" value="KVH95901"/>
        <property type="gene ID" value="Ccrd_002021"/>
    </dbReference>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000008">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF3">
        <property type="entry name" value="EXTERNAL ALTERNATIVE NAD(P)H-UBIQUINONE OXIDOREDUCTASE B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KVH95901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="637" mass="71582" checksum="4CE72F513BDBE770" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSS7</accession>
    <name>A0A103XSS7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO/COL/TOC1, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004347">
        <property type="protein sequence ID" value="KVH96214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSS7"/>
    <dbReference type="STRING" id="59895.A0A103XSS7"/>
    <dbReference type="Gramene" id="KVH96214">
        <property type="protein sequence ID" value="KVH96214"/>
        <property type="gene ID" value="Ccrd_001701"/>
    </dbReference>
    <dbReference type="OMA" id="NGAVVKW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018467">
        <property type="entry name" value="CCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040390">
        <property type="entry name" value="TIFY/JAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077:SF149">
        <property type="entry name" value="PROTEIN TIFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33077">
        <property type="entry name" value="PROTEIN TIFY 4A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09425">
        <property type="entry name" value="Jas_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="275" mass="29291" checksum="FBC1615653AB9A47" modified="2016-04-13" version="1">MERDFMGLNSRATVVKEEALKEPVFSISSDVRWPFSNGFEAFNNHQLGEIQSANFLQLHHDTKQAVPVSMSSPFFRHHLAGASVNPQLFGGVPVMSPHLVLPSTGSFFAPTTESWDSSKAASASAQLTIFYGAGKGAFVAAANGPQPRGQAPTNPAGDAVYMSQPISTQPCSAVSSPMSVSSHPVPQSTANKSEAAKRIGGSTTPVTQMDTPRVMSSFRQARQSAVPQARKASLARFLEKRKERVMASVPYRLGKNSIGSVANSTAVIAASEQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTC8</accession>
    <name>A0A103XTC8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004284">
        <property type="protein sequence ID" value="KVH96495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTC8"/>
    <dbReference type="Gramene" id="KVH96495">
        <property type="protein sequence ID" value="KVH96495"/>
        <property type="gene ID" value="Ccrd_001419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="86" mass="9293" checksum="5BD95B0C3B28E5EC" modified="2016-04-13" version="1">MSLFQSTVSHNLHYFNISFFVLHLVAFSFAFTAVILCSPPILPPHLIPLAGTTSKPSGVCQLVAIGGIGMDVAFQTTERDSHVYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTH6</accession>
    <name>A0A103XTH6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_001338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01004268">
        <property type="protein sequence ID" value="KVH96593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTH6"/>
    <dbReference type="STRING" id="59895.A0A103XTH6"/>
    <dbReference type="Gramene" id="KVH96593">
        <property type="protein sequence ID" value="KVH96593"/>
        <property type="gene ID" value="Ccrd_001338"/>
    </dbReference>
    <dbReference type="OMA" id="CHENFLH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH96593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="698" mass="78221" checksum="72DF251FC5A9D0C2" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTN1</accession>
    <name>A0A103XTN1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_001214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004252">
        <property type="protein sequence ID" value="KVH96693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTN1"/>
    <dbReference type="STRING" id="59895.A0A103XTN1"/>
    <dbReference type="Gramene" id="KVH96693">
        <property type="protein sequence ID" value="KVH96693"/>
        <property type="gene ID" value="Ccrd_001214"/>
    </dbReference>
    <dbReference type="OMA" id="CTHVYVE"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF47">
        <property type="entry name" value="OS09G0298500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH96693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="523" mass="57532" checksum="322B6AE014AD1018" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU46</accession>
    <name>A0A103XU46_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_001024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004127">
        <property type="protein sequence ID" value="KVH96883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU46"/>
    <dbReference type="STRING" id="59895.A0A103XU46"/>
    <dbReference type="Gramene" id="KVH96883">
        <property type="protein sequence ID" value="KVH96883"/>
        <property type="gene ID" value="Ccrd_001024"/>
    </dbReference>
    <dbReference type="OMA" id="RLVMIKE"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051762">
        <property type="term" value="P:sesquiterpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943:SF2">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943">
        <property type="entry name" value="CYTOCHROME P450 93A3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH96883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="500" mass="56578" checksum="E7F239A646501A67" modified="2016-04-13" version="1">MDSFSLALLILLTGTLFCYWCFTHLRHNKLPPGPMPLPIIGSLHLLGNLPHRALHKLSQKYGPIMSIRLGCVPFVIVSSPDAAKLFLGTHDAVFASRPEIQASKYLSYGSRGMTFAEYGPYWRSVRKFCAAELLSATKINSFLGMRREEIGLMLAEIRAASTVHKVVNVNETVGGLIEAMTCRMLFGKKNDERFVFKTLIDDSMEATGTFNLTDYVPVFAWFDLQGLTKRFKSLSKDIDEMFEIMIKEHEERSSTCSQRPDQMDFIDVLLSLNHHNSNTHDELSSTIDRSSMKAILLDMVAGSIDTAKTSIEWIMSALIRHPRVMKKLQKELNMIVGDTKMVEETDLTKLCYLHMVIKETLRLYPVGPLMVPHESIEDTLINGYNIPKKTRVLVNVWAFGRDPKVWSENWAEFLPERFLGRETDFRGSDFQLIPFGAGRRGCPGMNLGLLNIGLVVSNMVHGFDWVLPNGMSPNDLDMKEKFGLTTPREKPLLAIPINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUG0</accession>
    <name>A0A103XUG0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochodrial transcription termination factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_000770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003854">
        <property type="protein sequence ID" value="KVH97130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUG0"/>
    <dbReference type="STRING" id="59895.A0A103XUG0"/>
    <dbReference type="Gramene" id="KVH97130">
        <property type="protein sequence ID" value="KVH97130"/>
        <property type="gene ID" value="Ccrd_000770"/>
    </dbReference>
    <dbReference type="OMA" id="NIIRSHY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000005">
        <property type="entry name" value="Transcription termination factor MTERF4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF24">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH97130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="348" mass="39864" checksum="3CBD5CCE783134D1" modified="2016-04-13" version="1">MGEFVKKYPQVLHASVVVELVPVIRFLRGLDVERQDIGYVLVKYPELLGFKLEGTMSTSVAYLVSIGVNPRDIGPMVTQYPYFLGMKVGTMIKPLVEYLISLGLPKKVLARMFEKRAYVIGYDLEEMVRPNVDCLISFGIQREALASIIAQYPQILGLPLKAKLSSQQYFFNLKLKIDPNGFARVIERMPQLVSLSQKVIMKPIEFLVGRGISTEDVAKMIVKCPQLAALQVGIMKNSYYFFKSEMGRPLKELVEFPEFFTYGLESRIKPRYQRLQHKGIRSSLSWFLNCSDQRFEERLYADYIETEIEGPSFVMGGKLELSGDHDQMVSDEEDESDDEKLYRRTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUZ7</accession>
    <name>A0A103XUZ7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_000497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003833">
        <property type="protein sequence ID" value="KVH97388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUZ7"/>
    <dbReference type="STRING" id="59895.A0A103XUZ7"/>
    <dbReference type="Gramene" id="KVH97388">
        <property type="protein sequence ID" value="KVH97388"/>
        <property type="gene ID" value="Ccrd_000497"/>
    </dbReference>
    <dbReference type="OMA" id="RITNHNI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985">
        <property type="entry name" value="OS07G0668900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985:SF92">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PBL23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH97388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="259" mass="29064" checksum="FB12E21EA66C6EE6" modified="2016-04-13" version="1">MIGVQGNREFLAEVLTLSRVHHPNLVNLVGYCAHGHQRLLVYEYMMNGSLEEHLFDLDENTAPLDWHTRMKIAKGVAKGLEYLHDVADPPVIYRDLKSSNVLLDGDMNPKLSDFGLNKFAPREGEDHMSARVMGTYGYCSPEYAMTGELTTKSDVYSFGVVFLELISGRRVIDDTRPTEEENLVIWAKPLFKDPSKFPMVADPLLNDNYPIKSLHQAVAIAAMCLQDEASTRPYMSDVVVALDYLAMVQDHDVPSEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XVH5</accession>
    <name>A0A103XVH5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bet v I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_000233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003823">
        <property type="protein sequence ID" value="KVH97649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XVH5"/>
    <dbReference type="STRING" id="59895.A0A103XVH5"/>
    <dbReference type="Gramene" id="KVH97649">
        <property type="protein sequence ID" value="KVH97649"/>
        <property type="gene ID" value="Ccrd_000233"/>
    </dbReference>
    <dbReference type="OMA" id="VITWHVE"/>
    <dbReference type="OrthoDB" id="1072116at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051761">
        <property type="entry name" value="MLP-like_ligand-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31907">
        <property type="entry name" value="MLP-LIKE PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH97649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="151" mass="17233" checksum="A7D5BD5AD64DC624" modified="2016-04-13" version="1">MALTGKLIMYVDITSHGDIFHEMFRHRVHDLASISPDHFHGCEIDGQPGAVGSIIFFNYTRDGKKLTAKSMLEEVDEKNHKVVFNVIEGDLVEELYKSLKVIFHVEPKGDGQLAIWTLEFEKMNTNMPYPTSYMDFLLNVTTDLDSHCTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXE6</accession>
    <name>A0A103XXE6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prolamin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_023163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the plant egg cell-secreted peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003783">
        <property type="protein sequence ID" value="KVH98614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXE6"/>
    <dbReference type="STRING" id="59895.A0A103XXE6"/>
    <dbReference type="Gramene" id="KVH98614">
        <property type="protein sequence ID" value="KVH98614"/>
        <property type="gene ID" value="Ccrd_023163"/>
    </dbReference>
    <dbReference type="OMA" id="LREYCEF"/>
    <dbReference type="OrthoDB" id="782765at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009567">
        <property type="term" value="P:double fertilization forming a zygote and endosperm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080155">
        <property type="term" value="P:regulation of double fertilization forming a zygote and endosperm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000008">
        <property type="term" value="P:regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044711">
        <property type="entry name" value="EC11-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008502">
        <property type="entry name" value="Prolamin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35293:SF9">
        <property type="entry name" value="EGG CELL-SECRETED PROTEIN 1.4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35293">
        <property type="entry name" value="EGG CELL-SECRETED PROTEIN 1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05617">
        <property type="entry name" value="Prolamin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0278">Fertilization</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119188" evidence="9">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Prolamin-like" evidence="10">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVH98614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="135" mass="14783" checksum="47797A871734A946" modified="2016-04-13" version="1">MAFVRVLPITLLLLSCLMIMTFEVGSTARKMHVIEPGQGPVVRVQGEKNGVGGLMECWNALLELKSCTNEIILFFLNGDSYLTMECCRAIRIITYGCWPSMLTSLGFTSEEGDILRGYCGGAPLPQPVMLLGPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYK9</accession>
    <name>A0A103XYK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_022451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003613">
        <property type="protein sequence ID" value="KVH99318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYK9"/>
    <dbReference type="STRING" id="59895.A0A103XYK9"/>
    <dbReference type="Gramene" id="KVH99318">
        <property type="protein sequence ID" value="KVH99318"/>
        <property type="gene ID" value="Ccrd_022451"/>
    </dbReference>
    <dbReference type="OMA" id="LVNAWCS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044578">
        <property type="entry name" value="BIR6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47003">
        <property type="entry name" value="OS01G0970900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47003:SF9">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119215" evidence="3">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH99318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="52768" checksum="32FE09F2E76C76AB" modified="2016-04-13" version="1">MLLFARLIVLKRTALTLSDRTAFRTLKTAAGNHLSNVGVGGGGRDGTNDDYFATVHHISNIVRRDIYLERTLNKMCISRIVNSELVYRVLRSCCNSGIESFRFFNWVRTQHPQYEPTTVEFEELLMILARTRHWETMWKVAHQMKTQKLPISTSVVSFIIEHYGKNGLIDQAVELFNRCKNFNCSQTTEIYNSLLFALCEVKNFQGAYALVRRMVRKGVLPDKKTYSVLVNGWCSAGKMKEAQSFLEEMSLKGFNPPVRGRDLLIDGLLNAGYLESAKGLVRKMTKEGFVPDVSTFNSLAEAICQSGEIDFCVGLYHDVCRLGLCPDIETYKIMIAATSKVGRIDEAFSILYRSLEDGNKPFPSLYAPILKGLCRNGLFDDAFSFFSDMKVKGHPPNRPVYTMLLKMCARGGRYIEAANYLMEMTEFKLSPMSRHFDMVTDGLKNCGKHDMAKRIEQLEISLRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0N4</accession>
    <name>A0A103Y0N4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_021391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0N4"/>
    <dbReference type="STRING" id="59895.A0A103Y0N4"/>
    <dbReference type="Gramene" id="KVI00372">
        <property type="protein sequence ID" value="KVI00372"/>
        <property type="gene ID" value="Ccrd_021391"/>
    </dbReference>
    <dbReference type="OMA" id="MEAKRIY"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008922">
        <property type="term" value="F:long-chain fatty acid [acyl-carrier-protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052987">
        <property type="entry name" value="Chloroplast_AMP-bd_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43813">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 16, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43813:SF1">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 16, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="747" mass="83818" checksum="8EB8608C3C07D4A8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0P1</accession>
    <name>A0A103Y0P1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-locus glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003390">
        <property type="protein sequence ID" value="KVI00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0P1"/>
    <dbReference type="STRING" id="59895.A0A103Y0P1"/>
    <dbReference type="Gramene" id="KVI00387">
        <property type="protein sequence ID" value="KVI00387"/>
        <property type="gene ID" value="Ccrd_021341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF4">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="S-locus glycoprotein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12572" checksum="7C2BA4DAB6710E1E" modified="2016-04-13" version="1">MRSAVIIQYNIVYGIFSYKLSDNLDGNLRVYSLNESSGLWLITWQAIAQPCNVHGICGRNGICTHGEKLECSCPSGYEWSDPTDLTQGCMPPFNKTCGNPTSFGFLELPHTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y2A3</accession>
    <name>A0A103Y2A3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">phosphatidylglycerophosphatase</fullName>
            <ecNumber evidence="10">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_020515</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Exhibits phosphatidylglycerophosphate phosphatase activity. Involved in root growth and columella cells organization. May possess protein phosphatase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01003124">
        <property type="protein sequence ID" value="KVI01196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y2A3"/>
    <dbReference type="STRING" id="59895.A0A103Y2A3"/>
    <dbReference type="Gramene" id="KVI01196">
        <property type="protein sequence ID" value="KVI01196"/>
        <property type="gene ID" value="Ccrd_020515"/>
    </dbReference>
    <dbReference type="OMA" id="TIVEYKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000051">
        <property type="entry name" value="Dual specificity phosphatase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="64"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="132"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI01196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="279" mass="31210" checksum="126E1C7BD40C039A" modified="2016-04-13" version="1">MKIVDLDDSCEVKNSKQIVDYNYSRQIVTVDAKRVLVGAGARILFYPTLLYNVCRNKIQAEFRWWDQIDQYLLLGAVPFPKDVPRLKQLGVGGVITLNEPYETLVPTSLYRAHGIDHLVIPTRDYLFAPSFVDIDRAVNFIHKNATSCRTTYVHCKAGRGRSTTIVEYKHMTPASALEYVRSRRPRVLLAPSQWKAVQEYRQWRIASTATPSPSGDAVLITKADLEGYHSPSQGKELALVPRGARTRPMIAKLSCLFASLKVSGGCAPINMKLTEAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3A5</accession>
    <name>A0A103Y3A5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_020001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002712">
        <property type="protein sequence ID" value="KVI01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3A5"/>
    <dbReference type="Gramene" id="KVI01720">
        <property type="protein sequence ID" value="KVI01720"/>
        <property type="gene ID" value="Ccrd_020001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="22" mass="2693" checksum="A22B729215DF39FF" modified="2016-04-13" version="1">MVNRRCLDRFKVFISQGLSEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5W5</accession>
    <name>A0A103Y5W5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H2, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_018640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002572">
        <property type="protein sequence ID" value="KVI03069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5W5"/>
    <dbReference type="STRING" id="59895.A0A103Y5W5"/>
    <dbReference type="Gramene" id="KVI03069">
        <property type="protein sequence ID" value="KVI03069"/>
        <property type="gene ID" value="Ccrd_018640"/>
    </dbReference>
    <dbReference type="OMA" id="SQFTYWN"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI03069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="165" mass="18363" checksum="7CF4C3F699015091" modified="2016-04-13" version="1">MEGENASMETGIIDLGSVRSSSSVDLTDQVHQLPCCIKYNGPSPVSHYFKPKPNGIEVDGLNVKEAYFRGRRLQGTTVPLPDDYSGFVIGRKSSAKRKACNNDANTTYWQMNAKFENITLWNHDNLPSKEDGFLRAFHWLHVAKALHKPVTTEDLESASNPGAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5X5</accession>
    <name>A0A103Y5X5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine aminopeptidase 2</fullName>
            <shortName evidence="12">MAP 2</shortName>
            <shortName evidence="12">MetAP 2</shortName>
            <ecNumber evidence="12">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_018596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01002547">
        <property type="protein sequence ID" value="KVI03110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y5X5"/>
    <dbReference type="STRING" id="59895.A0A103Y5X5"/>
    <dbReference type="Gramene" id="KVI03110">
        <property type="protein sequence ID" value="KVI03110"/>
        <property type="gene ID" value="Ccrd_018596"/>
    </dbReference>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000003">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="15">
        <location>
            <begin position="117"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI03110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="427" mass="47750" checksum="10BA89C78A539EA6" modified="2016-04-13" version="1">MAKEDTNGGAGTSNGMVSDVPATVEEVNDKVDELTLADSSETGVQEAAKKKKKKNKSKRKKETKEQTDPPTIPVSELFSQGNFPEGEIQQYKDDNLWRSTSEEKRDLERLEKPMYDSVRQAAEVHRQVRKYIRSILKPGMLMVDLCETLENTVRKLISENGLQAGIAFPTGCSLNWVAAHWTPNSGDKTVLQYDDVMKLDFGTHINGHIVDCAFTVAFNPMFDPLLEASREATNTGIKEAGIDVRLCDIGAAIQEVMESYEVEINGKVFQVKSIRNLNGHSIGPYQIHAGKSVPIVKGGEQTKMEEGEFYAIETFGSTGKGYVREDLECSHYMKNFDVGHVPLRLPRAKQLLATIDKNFSTLAFCRRYLDRLDETKYLMALKNLCDAGVVQPYPPLCDTKGSYVSQFEHTILLRPTCKEVISRGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y641</accession>
    <name>A0A103Y641_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01002407">
        <property type="protein sequence ID" value="KVI03221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y641"/>
    <dbReference type="STRING" id="59895.A0A103Y641"/>
    <dbReference type="Gramene" id="KVI03221">
        <property type="protein sequence ID" value="KVI03221"/>
        <property type="gene ID" value="Ccrd_018480"/>
    </dbReference>
    <dbReference type="OMA" id="ISNYGEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF54">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119425" description="mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="62"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="424" mass="48624" checksum="4E224AF2177291BC" modified="2016-04-13" version="1">MDIHKTIFLMAILFIYSHHTNSLLLGLYQDQDSDIMLEKTSNHFSEHRIDDMDEMEDDSWAMVQKSGNQFVVNDQPFYVNGFNTYWLMVLAADESTRGKVTEVFRQASAVGLTVCRTWAFNDGQWRALQKKPSVYDEDVFKALDFVVSEAKKFKIRLILSLINNWGGYGGKPQYVKWGNEAGLNLTNEDDFFSHPTLRSYYQSHTVLNRVNTVSNMTYKDDPTIFAWELMNEPRCPSDPSGDKLQDFMGLQHLTRFNIIQILMLNKWELISSETIKFLVLILLLISPSISDAHISFTKSWMQSHIDDAEQYLGMPVVFSEFGVSAKDQGYNISFRDTLISTVYNTVLDSVRKGGSGGGSLLWQVFPDGTEYMDDGYAIVLSKSPSTSNIISRHSTRLTLFNSLCKWKCHWGCKKKHGFQYHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y6L2</accession>
    <name>A0A103Y6L2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_018242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002350">
        <property type="protein sequence ID" value="KVI03456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y6L2"/>
    <dbReference type="STRING" id="59895.A0A103Y6L2"/>
    <dbReference type="Gramene" id="KVI03456">
        <property type="protein sequence ID" value="KVI03456"/>
        <property type="gene ID" value="Ccrd_018242"/>
    </dbReference>
    <dbReference type="OMA" id="HPGLTQQ"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000268">
        <property type="entry name" value="Centrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000256">
        <property type="entry name" value="probable calcium-binding protein CML20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI03456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="168" mass="19203" checksum="632C9CA4D6432DFC" modified="2016-04-13" version="1">MGVYGEQSRRDKPGRRNHGLTQQKRQEIKEAFELFDTDGSGTIDAKELNVAMRALGFEMTEEQINQMIADVDKDGSGAIDFDEFVHMMTAKIGERDSKEELTKAFHIIDQDKNGKISVEDIKHIAKELGEHFTDAEIHEMVEEADRDHDGEVGAEEFMRMMKRTSYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7M6</accession>
    <name>A0A103Y7M6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_017689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01002317">
        <property type="protein sequence ID" value="KVI04017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7M6"/>
    <dbReference type="Gramene" id="KVI04017">
        <property type="protein sequence ID" value="KVI04017"/>
        <property type="gene ID" value="Ccrd_017689"/>
    </dbReference>
    <dbReference type="OMA" id="KYAYHCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000021">
        <property type="entry name" value="ATP-dependent RNA helicase DEAH13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="243"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="573"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI04017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1253" mass="141323" checksum="3307F1B82BE601F5" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7R5</accession>
    <name>A0A103Y7R5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nickel/cobalt transporter, high-affinity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002312">
        <property type="protein sequence ID" value="KVI04074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7R5"/>
    <dbReference type="STRING" id="59895.A0A103Y7R5"/>
    <dbReference type="Gramene" id="KVI04074">
        <property type="protein sequence ID" value="KVI04074"/>
        <property type="gene ID" value="Ccrd_017629"/>
    </dbReference>
    <dbReference type="OMA" id="NSVSCKH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052776">
        <property type="entry name" value="Chloro_ReproSupport/MetalTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33876:SF4">
        <property type="entry name" value="CHLOROPLAST PROTEIN FOR GROWTH AND FERTILITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33876">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="408" mass="44067" checksum="B953F54730782793" modified="2016-04-13" version="1" fragment="single">QDFYPEIHHFSVNSVEQLLTHSERGGDNGRHGGATMEKLIYNPNHHILSKHLKPRPFFPHLARFQPTKLFNPSHYTIRVNSISCKHEQNPSFDSSSPVIKTPERDLTFSENKGSVIPKPQFLQQLSQAFSHKQKAAAAGTVILLSALLVFVVQPVFVSPAFASFQTATKTGSGAFARSELLSSAWTGFFAGCLHTLSGPDHLAALAPLSIGRSRVESAMVGALWGCGHDAGQVIFGLLFLLLKDRLHIEIIRTWGTRVVGFTLLVIGAMGIREASEVPTPCVALENGECDVSVYEASIADPTVGKKKKIGFATFATGIIHGLQPDALMMVLPALALPSRMAGAAFLGMFLVGTVIAMGSYTVFIGSCSQALKDRIPRITEKLTWISSLVAIALGLGIIVSQLFGFSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7Y0</accession>
    <name>A0A103Y7Y0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="12">HMG-CoA reductase</shortName>
            <ecNumber evidence="12">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_017513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="12"/>
    <dbReference type="EMBL" id="LEKV01002301">
        <property type="protein sequence ID" value="KVI04181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y7Y0"/>
    <dbReference type="STRING" id="59895.A0A103Y7Y0"/>
    <dbReference type="Gramene" id="KVI04181">
        <property type="protein sequence ID" value="KVI04181"/>
        <property type="gene ID" value="Ccrd_017513"/>
    </dbReference>
    <dbReference type="OMA" id="QMFKANN"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016135">
        <property type="term" value="P:saponin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000002">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF56">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI04181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="602" mass="64526" checksum="1E39EDE867512B90" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y942</accession>
    <name>A0A103Y942_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NERD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_016889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001910">
        <property type="protein sequence ID" value="KVI04790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y942"/>
    <dbReference type="STRING" id="59895.A0A103Y942"/>
    <dbReference type="Gramene" id="KVI04790">
        <property type="protein sequence ID" value="KVI04790"/>
        <property type="gene ID" value="Ccrd_016889"/>
    </dbReference>
    <dbReference type="OMA" id="NCRPSYA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287:SF1">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119500" evidence="1">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI04790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="320" mass="36071" checksum="47DB6375C0446C9E" modified="2016-04-13" version="1">MWVELIFGLVVIYRVVRRFFYDDEDHVDFGSSGSNALFAVAERLQALYGGKAYVGLRIPDPDTASRQNIDLVLVTKKEAVVVSVINASGIASIDGDGTWVCTDGSKHKTERLQDPMVEAKRQAAVLESYLEQRGVALPDGYLSCKIVCPNPNFRTIHPDYFPPEVVTYEQWTELKPERKSISGWIKGALHGDKKEMQESVQNLGFILSTAPMWDRLELKNNIQLLGEFLEFKGKQDDILSLRNIKRSKVSRLTIQKTSMFAHSKLQLLYAPRDYRSEGGSGLDWNEVTVRSSTEVLFQLQDPAKVQKIKLSSIINMSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YB99</accession>
    <name>A0A103YB99_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_015717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001857">
        <property type="protein sequence ID" value="KVI05933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KVI05933">
        <property type="protein sequence ID" value="KVI05933"/>
        <property type="gene ID" value="Ccrd_015717"/>
    </dbReference>
    <dbReference type="OMA" id="NMEMQHV"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009914">
        <property type="term" value="P:hormone transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000032">
        <property type="term" value="P:regulation of secondary shoot formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000179">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000532">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000059">
        <property type="entry name" value="ABC transporter G family member 40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
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                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
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                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
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                <person name="Faccioli P."/>
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                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001852">
        <property type="protein sequence ID" value="KVI06071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YBJ9"/>
    <dbReference type="STRING" id="59895.A0A103YBJ9"/>
    <dbReference type="Gramene" id="KVI06071">
        <property type="protein sequence ID" value="KVI06071"/>
        <property type="gene ID" value="Ccrd_015579"/>
    </dbReference>
    <dbReference type="OMA" id="DLGQWVG"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000013">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI06071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="144" mass="15278" checksum="FCC7F6669672049B" modified="2016-04-13" version="1">MAGEEAVVPVEVAAPAPAPALGEPMDIMTALQLVLRKSLAHGGLVRGLHEAAKVIEKHAAQICVLAEDCNQPDYQKLVKALCADHNVSLITVPSAKTLGEWAGLCKIDSEGKARKVVGCSCLVVKDYGEESEGLHIVQEYVKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDF9</accession>
    <name>A0A103YDF9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_014583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001525">
        <property type="protein sequence ID" value="KVI07061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDF9"/>
    <dbReference type="STRING" id="59895.A0A103YDF9"/>
    <dbReference type="Gramene" id="KVI07061">
        <property type="protein sequence ID" value="KVI07061"/>
        <property type="gene ID" value="Ccrd_014583"/>
    </dbReference>
    <dbReference type="OMA" id="SKMAPNW"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057649">
        <property type="entry name" value="PUB62-63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33644">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33644:SF7">
        <property type="entry name" value="ZINC FINGER, RING_FYVE_PHD-TYPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23112">
        <property type="entry name" value="PUB62-63_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI07061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="462" mass="50353" checksum="F6FE662D2C7BB420" modified="2016-04-13" version="1">MASEETGLVLSHRLDSNHPQLLFQDDSNSGFVCNPPNQRPGSGPDRPAAGTTSNNGKATRELTGFIDHQHRYYQTQSTTEFRQSMYNPGPVHHRGLQNWHGGNGRASNSASGDGSDGNDNDDDVEGLVNSSDNKNNNSSNTSGHSSEKDGNAKLNHLSSFGSSREVVKVGSVVPSRNDLNGVRPSSSENHQQGQVGQYQNAVALVDRDGELYYSQYLHRAEGSGAGLKDVMVANGCGFSGRKDVSYSGESGDSLRAILSDPLTGALMDDAMILPCGHSFGSDGMQHVMKMKVCCTCSHPVSEGSVASNLSLRSAVLAFRREEELQVHHASKRRRERLEQDRLNHGDSMFMDTPRGRGLQFPFSVSDRVIIKVFVKSRLKRLDVFACLLNSTTLNQGNKRTPERFVGCEAVITTQCLNGWSVLYVVKTLDNAESIKLQYRSLAKVSDDSSSHPTSSKMTPNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YDN3</accession>
    <name>A0A103YDN3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_014456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001513">
        <property type="protein sequence ID" value="KVI07184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YDN3"/>
    <dbReference type="Gramene" id="KVI07184">
        <property type="protein sequence ID" value="KVI07184"/>
        <property type="gene ID" value="Ccrd_014456"/>
    </dbReference>
    <dbReference type="OMA" id="HLVEWAT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF92">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI07184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="181" mass="20282" checksum="466C123EE92BF516" modified="2016-04-13" version="1">MESALDVGILGRDRHKNLLEIRGFHAWGDQRIIVYDYMHNHSLLTHLHGQLAANCLLDWPQRMNIAIGSAEGLADINANNVLLDSEYLAKVADFMMAKLVPDGVTHMSTRVKGSLGYLAPDYAMWGKVSRRSDVYSFGLLLLEILSAKKPLEKLPEGFNLHLVEWATPLVEHDAYDQLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YEY6</accession>
    <name>A0A103YEY6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_013779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001480">
        <property type="protein sequence ID" value="KVI07857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YEY6"/>
    <dbReference type="STRING" id="59895.A0A103YEY6"/>
    <dbReference type="Gramene" id="KVI07857">
        <property type="protein sequence ID" value="KVI07857"/>
        <property type="gene ID" value="Ccrd_013779"/>
    </dbReference>
    <dbReference type="OMA" id="EYFANTR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF166">
        <property type="entry name" value="OS02G0617400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI07857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="119" mass="13554" checksum="3FC5DEC2298DDCC1" modified="2016-04-13" version="1" fragment="single">MGMESPLPYLNPLLKGETLLSGANFASAGIGILNDTGIQFLNIIRIWKQIEYFEQYQIRLASIIGRDRARQIVSNAISLISLGGNDFVNNYYLLPFSARSRQYALPDYVRYLVSEYRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YFU4</accession>
    <name>A0A103YFU4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, ATP binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_013297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001138">
        <property type="protein sequence ID" value="KVI08336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YFU4"/>
    <dbReference type="STRING" id="59895.A0A103YFU4"/>
    <dbReference type="Gramene" id="KVI08336">
        <property type="protein sequence ID" value="KVI08336"/>
        <property type="gene ID" value="Ccrd_013297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF140">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI08336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="78" mass="8775" checksum="90F076D9AD09084E" modified="2016-04-13" version="1">MFGKPNSQFQFVNLQPLNNVTAMAANSPTTTTRKESQFLILGRYEIEKLLGHGTFSKVYLARNVKTNESVAIKVIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YGZ3</accession>
    <name>A0A103YGZ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_012690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001078">
        <property type="protein sequence ID" value="KVI08921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YGZ3"/>
    <dbReference type="STRING" id="59895.A0A103YGZ3"/>
    <dbReference type="Gramene" id="KVI08921">
        <property type="protein sequence ID" value="KVI08921"/>
        <property type="gene ID" value="Ccrd_012690"/>
    </dbReference>
    <dbReference type="OMA" id="YYGRLTM"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES17W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI08921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="146" mass="16431" checksum="0CD731A26438C39C" modified="2016-04-13" version="1">MGRVRTKTVKKSSRIVIERYYGKMTLDFHTNEKILEEVAIIPSKRLRNKIAGFSTHLMKRIQKGPVRGISLKLQEEERERRMDFVPDESAIKTDLIEVDKETIEMLTALGMADLPGVVTKSVEPQALPSVPAFGRGGDGGGFARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHA2</accession>
    <name>A0A103YHA2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dyskerin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_012546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001070">
        <property type="protein sequence ID" value="KVI09087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHA2"/>
    <dbReference type="STRING" id="59895.A0A103YHA2"/>
    <dbReference type="Gramene" id="KVI09087">
        <property type="protein sequence ID" value="KVI09087"/>
        <property type="gene ID" value="Ccrd_012546"/>
    </dbReference>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI09087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="621" mass="69096" checksum="21E749CFA57BCAA8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHP1</accession>
    <name>A0A103YHP1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_012327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001067">
        <property type="protein sequence ID" value="KVI09290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHP1"/>
    <dbReference type="Gramene" id="KVI09290">
        <property type="protein sequence ID" value="KVI09290"/>
        <property type="gene ID" value="Ccrd_012327"/>
    </dbReference>
    <dbReference type="OMA" id="MFVANER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI09290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="136" mass="15467" checksum="19FBDFFD49C22822" modified="2016-04-13" version="1">MGMEGESINQRVVLIHDASGGVRTNAVRWIIDGFSLKPGDMFTFLSVLHEIHHPSMFDSFQILTSKLVHLLLSDLVLVGYKIRVDGSMFGANQKAIDKELERRKKEYKDNLELVQISKLYEMHEVTEGNFVFLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YHV7</accession>
    <name>A0A103YHV7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_012288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001064">
        <property type="protein sequence ID" value="KVI09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YHV7"/>
    <dbReference type="STRING" id="59895.A0A103YHV7"/>
    <dbReference type="Gramene" id="KVI09352">
        <property type="protein sequence ID" value="KVI09352"/>
        <property type="gene ID" value="Ccrd_012288"/>
    </dbReference>
    <dbReference type="OMA" id="ICLMSMK"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23114">
        <property type="entry name" value="RING-H2_WAVH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01466">
        <property type="entry name" value="vWA_C3HC4_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF158">
        <property type="entry name" value="RETROELEMENT POL POLYPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="248"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="711" mass="77607" checksum="EA3D03EDDD7863D3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIH6</accession>
    <name>A0A103YIH6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_011928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001047">
        <property type="protein sequence ID" value="KVI09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIH6"/>
    <dbReference type="STRING" id="59895.A0A103YIH6"/>
    <dbReference type="Gramene" id="KVI09685">
        <property type="protein sequence ID" value="KVI09685"/>
        <property type="gene ID" value="Ccrd_011928"/>
    </dbReference>
    <dbReference type="OMA" id="ILMESSY"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000006">
        <property type="entry name" value="Agamous-like MADS-box protein AGL62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF629">
        <property type="entry name" value="OS02G0164450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="219" mass="24584" checksum="7230D5C6DF65308E" modified="2016-04-13" version="1">MAKKPSLGRQKIKIAKIQIKNHLQVTFSKRRSGLFKKASELCTLCGVEIAIVVFSPAGKVFSFGHPKVESIVDRFLTRNPKLNSTSLHVIEAHRIASIPELNMQLTHLLNELEVEKKRSETLDEMRKASQSQFWWEAPIADLTLHELEQLKDSMEELKKTVAIQANKLFVENSNSVPIFGANNNIRGGLDHYDIKPPPIISSSSSASHIHNYGYGLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YII6</accession>
    <name>A0A103YII6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar pre-ribosomal-associated protein 1, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001044">
        <property type="protein sequence ID" value="KVI09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103YII6"/>
    <dbReference type="Gramene" id="KVI09717">
        <property type="protein sequence ID" value="KVI09717"/>
        <property type="gene ID" value="Ccrd_011905"/>
    </dbReference>
    <dbReference type="OMA" id="EVGNPRM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="1848"/>
            <end position="2037"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="2423" mass="271830" checksum="97B7BC39F8FB2C4C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YIJ0</accession>
    <name>A0A103YIJ0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_011847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001043">
        <property type="protein sequence ID" value="KVI09754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YIJ0"/>
    <dbReference type="STRING" id="59895.A0A103YIJ0"/>
    <dbReference type="Gramene" id="KVI09754">
        <property type="protein sequence ID" value="KVI09754"/>
        <property type="gene ID" value="Ccrd_011847"/>
    </dbReference>
    <dbReference type="OMA" id="MEWHEPA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF6">
        <property type="entry name" value="PROTEIN RETARDED ROOT GROWTH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="390" mass="43733" checksum="69CACCA2126F1C2A" modified="2016-04-13" version="1">MLRPPVKMWRHHRSIDVHMKTATTMLFLHSLSSSHTLSFKKMGTIISLSTNPNAILSTSGPPQKSVQINPRRSSINLCRLSHSSSSPIAPTGRGYLGSSSNSIVAKCFSYSSSSSSSPSVSVADTMEWHEPAACAEVDDSYNDDVSEEDLKPSIPVRAYFFSTSVDLRSLVDQNKSNFIPPTSRMTNYVVLRFGSTKPELIGSGASISGSDCCYMVVFQYGSIVLFNVRDHEIDGYLKIVERHASGLLPEMRKDGEVDGMVGEFTDINRGMEKTGTFTMKRKKLFQLVGKANSNLADVILKLGLFERSDIAWKDAKYAQIWEYLRDEFELTQRFASLDFKLKFVEHNIRFLQEILQNRKSDFLEWVIIILIVAEILISVYDIAHKSVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ32</accession>
    <name>A0A103YJ32_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plant bHLH transcription factor ACT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_011612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001032">
        <property type="protein sequence ID" value="KVI09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ32"/>
    <dbReference type="STRING" id="59895.A0A103YJ32"/>
    <dbReference type="Gramene" id="KVI09998">
        <property type="protein sequence ID" value="KVI09998"/>
        <property type="gene ID" value="Ccrd_011612"/>
    </dbReference>
    <dbReference type="OMA" id="SHADNDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04873">
        <property type="entry name" value="ACT_UUR-ACR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant bHLH transcription factor ACT-like" evidence="4">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="191" mass="22039" checksum="7E3BA0F9A9F72CCD" modified="2016-04-13" version="1" fragment="single">GNKRERERERERGRERSRERERGEIVKKQQLNMVSREHKKATLHEKLQLLRSITNSHANNDSSIIRDASKYIQELKHKVQILNQDIASGQSTSSYQNSWPMVTVEALEKGIQVNLYSERSCPGLLVFVWKVFEELGLNVLEARVSCTGSFQLEALGVERQENGETIDVQMVKQAILHAIENWSQNNDHQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YJ65</accession>
    <name>A0A103YJ65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clp, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_011509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001029">
        <property type="protein sequence ID" value="KVI10059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YJ65"/>
    <dbReference type="STRING" id="59895.A0A103YJ65"/>
    <dbReference type="Gramene" id="KVI10059">
        <property type="protein sequence ID" value="KVI10059"/>
        <property type="gene ID" value="Ccrd_011509"/>
    </dbReference>
    <dbReference type="OMA" id="IDWAINE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044217">
        <property type="entry name" value="CLPT1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47016">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPT1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47016:SF1">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPT1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="120"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVI10059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="277" mass="31295" checksum="41BDA4BE83EF4D3A" modified="2016-04-13" version="1" fragment="single">YIYILFKDRKKNRKRRLRFHGRRLNKKLVRVFFVSPMAAQSLSVLPVSPSSSGCRCRNSYNSSFLAPRIITSRVMVTSFVGLHLSIQQSKSRHRTFGRYSSIVATVESSPTTPTSEKETPEKSAKWSFRFIKSFAMGELEARKLKFMNTGTEALLMGILVEGTSLAAKLLRESGVTLFKVREETVRLLGKSDMYIFSPEHPPLTEPARRAIDWAINEKLKSGETGEVTTSHLLLGIWAEKESAAHKIMATLGFDDDKAKELAKSMDKEIILSYKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKH1</accession>
    <name>A0A103YKH1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_010786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000997">
        <property type="protein sequence ID" value="KVI10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKH1"/>
    <dbReference type="STRING" id="59895.A0A103YKH1"/>
    <dbReference type="Gramene" id="KVI10811">
        <property type="protein sequence ID" value="KVI10811"/>
        <property type="gene ID" value="Ccrd_010786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47459">
        <property type="entry name" value="KINESIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47459:SF1">
        <property type="entry name" value="KINESIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVI10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="242" mass="27298" checksum="B60877DE00D3B855" modified="2016-04-13" version="1">MDASFDHHELGLASLKIGLKLDEEGEYPEKVFDYANKSLKILDEIDNGLSLPLEEHGKALKQNQLSQKVLKNWVRTSDLLRAEIDATNMQIALGKFDEAINTLKGVVLLTDKESEERAMIFVSIAKALCNQEKFQEMKRCLQMACGILDKKEKSSPLEVSEAYMEISIQYVTMNEFKTAISLLKRAQAMLEKISEEQHSVGRASARIGWLLLLTGKVQESVSYLEDATERLKKIFGSKHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKT6</accession>
    <name>A0A103YKT6_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Squalene monooxygenase</fullName>
            <ecNumber evidence="5 14">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ccrd_010728</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways. Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25283"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="5 14"/>
    <dbReference type="EMBL" id="LEKV01000988">
        <property type="protein sequence ID" value="KVI10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKT6"/>
    <dbReference type="STRING" id="59895.A0A103YKT6"/>
    <dbReference type="Gramene" id="KVI10870">
        <property type="protein sequence ID" value="KVI10870"/>
        <property type="gene ID" value="Ccrd_010728"/>
    </dbReference>
    <dbReference type="OMA" id="KNCEAPY"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046246">
        <property type="term" value="P:terpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000074">
        <property type="entry name" value="Squalene monooxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF19">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="15">
        <location>
            <begin position="213"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KVI10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="470" mass="51133" checksum="A90B71AB03D66A16" modified="2016-04-13" version="1" fragment="single">MELKILQQYILGGIIATWLGFALIYFLGVKKSKPADDNLDLHKQVNELVRIQPQNDGSPEVIIVGAGVAGAALAYSLGKDGRRILVIERDLGLQDRIVGELLQPDCVENIDAQKVFGYALFKEDKSTRLAYPLEKFTRDVSGRSFHNGRFVQRMREKAATVPNSLTIHVRTFSVRLEQGTVTSLIEEKGAVKGVRYKTKAGQDITANAPLTIVEIPSSFVALLLKNCEAPYPNHGHVILADPSPILCYRISSTEIRCLVDIPGKKIPSVGNGEMALYLKTKVAPQIPPELQGGFIAAVDEGKIKTMANRSMPAAPQPTPGAILLGDSFNMRHPLTGGGMTVALSDVVVVRDLLRPLDNLNDSIALCKYLDSFYTLRKPVASTINTLAGALYKVFSASPDQARTELRQACFDYLSLGGMCSSGPIALLSGLNPKPSSLVLHFFSVAIFGVGRLLLPYPSPRRTWLGARLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YKY9</accession>
    <name>A0A103YKY9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_010549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NIPA (TC 2.A.7) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000938">
        <property type="protein sequence ID" value="KVI11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YKY9"/>
    <dbReference type="Gramene" id="KVI11044">
        <property type="protein sequence ID" value="KVI11044"/>
        <property type="gene ID" value="Ccrd_010549"/>
    </dbReference>
    <dbReference type="OMA" id="DMIEYPK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF89">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="39414" checksum="70E232FA1083EEB0" modified="2016-04-13" version="1">MASHSWKDAYRGMSVDNIKGLVLALSSSLFIGASFIVKKKGLKKAGASGIRAAILSIQISFRMYVLWLAFSICFDNTVDLVPLTNFTLFSGVGGYSYLYEPLWWVGMITSDAVLAHIILREKLHIFGVLGCVLCVVGSITIVLHAPQERPIESVTEVWDLATEPAFVLYAVLVLIAVFILVFHYIPSYGQTHIMCYIGVCSLVGSLSVMSVKAIGIALKLTLSGMNQLVFPQTWAFTFIVLLCIITQMNYLNKALDTFNTAVVSPIYYVMFTSLTILASVIMFKDWDRQNPSQIITELCGFVTILSGTFLLHKTKDMVDGPIPLSVRSPKHMEDEEDGIDSESIPLRRQDTSTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103YMY5</accession>
    <name>A0A103YMY5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ccrd_009507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000016">
        <property type="protein sequence ID" value="KVI12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103YMY5"/>
    <dbReference type="STRING" id="59895.A0A103YMY5"/>
    <dbReference type="Gramene" id="KVI12069">
        <property type="protein sequence ID" value="KVI12069"/>
        <property type="gene ID" value="Ccrd_009507"/>
    </dbReference>
    <dbReference type="OMA" id="DCGPTLE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08378">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04019">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000119">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000128">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047257">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047258">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF50">
        <property type="entry name" value="FT-INTERACTING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="186"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="348"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KVI12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="776" mass="89233" checksum="ACE64E7015B9DB1F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118I1T4</accession>
    <name>A0A118I1T4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_026192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007612">
        <property type="protein sequence ID" value="KVG79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118I1T4"/>
    <dbReference type="STRING" id="59895.A0A118I1T4"/>
    <dbReference type="Gramene" id="KVG79775">
        <property type="protein sequence ID" value="KVG79775"/>
        <property type="gene ID" value="Ccrd_026192"/>
    </dbReference>
    <dbReference type="OMA" id="YNYKNED"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19124">
        <property type="entry name" value="AKR_AKR4A_4B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000014">
        <property type="entry name" value="NAD(P)-linked oxidoreductase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000013">
        <property type="entry name" value="NADPH-dependent codeinone reductase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044497">
        <property type="entry name" value="AKR4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="303"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVG79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="591" mass="67370" checksum="0D8D855C6336D5F9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JRP0</accession>
    <name>A0A118JRP0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_024850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01005779">
        <property type="protein sequence ID" value="KVH87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JRP0"/>
    <dbReference type="STRING" id="59895.A0A118JRP0"/>
    <dbReference type="Gramene" id="KVH87834">
        <property type="protein sequence ID" value="KVH87834"/>
        <property type="gene ID" value="Ccrd_024850"/>
    </dbReference>
    <dbReference type="OMA" id="PFEMTIN"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="346" mass="38237" checksum="89675F8AA7B659D3" modified="2016-04-13" version="1">MGCSFSGLNALYDAVSGGADVWINDNRFKVVSQLGEGGFAYVFLVKEVINDASGGGVSKKFKDPSHISEDGTYAMKKVLIQNNDQLEMVKEEIRVSSLFSHPNLLPLLDHAIIPVKGTPEQTWTHEAYLLFPVHLDGTLLDNAKTMKSKKEFFSTSDVLQIFRQLCAGLKHLHTLDPPYAHNDVKPGNVLLTHRKGQPPLAILMDFGSARPARKQIRSRSEALQLQEWAAENVSAPFRAPELWDCPSQTDIDERTDVWSLGCTLFAIMYGASPFEYALGESGGSLQLAIINGQIKWPSASGGGPKPPYPEALHQFVSWMVQPQATVRPHIDDIIIHVDKLISKFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JSS7</accession>
    <name>A0A118JSS7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005264">
        <property type="protein sequence ID" value="KVH89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JSS7"/>
    <dbReference type="SMR" id="A0A118JSS7"/>
    <dbReference type="STRING" id="59895.A0A118JSS7"/>
    <dbReference type="Gramene" id="KVH89292">
        <property type="protein sequence ID" value="KVH89292"/>
        <property type="gene ID" value="Ccrd_008722"/>
    </dbReference>
    <dbReference type="OMA" id="WRYTRTE"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000131">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="145" mass="16457" checksum="7A994CAC44AEC38C" modified="2016-04-13" version="1">MPKNKGKGGKNRKRGKNEADDEKRELVFKEDGQEYAQVLRMLGNGRCEAMCIDGTKRLSHIRGKMHKKVWIAAGDIILVGLRDYQDDKADVILKYMPDEARLLKAYGELPENIRLNEGIAGGLDEEDDNAGDDYIEFEDEDIDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JU31</accession>
    <name>A0A118JU31_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_007459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005099">
        <property type="protein sequence ID" value="KVH90582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JU31"/>
    <dbReference type="STRING" id="59895.A0A118JU31"/>
    <dbReference type="Gramene" id="KVH90582">
        <property type="protein sequence ID" value="KVH90582"/>
        <property type="gene ID" value="Ccrd_007459"/>
    </dbReference>
    <dbReference type="OMA" id="HRNMNAG"/>
    <dbReference type="OrthoDB" id="1904011at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35286">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35286:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH90582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="211" mass="24096" checksum="5C5DF37797B6A108" modified="2016-04-13" version="1">MSSYTNTPNLDHLLLQTLMGRLQIRPPNPLQPQLSPSFNKTLEDLLMDTINNISDAEDDQDDDDDDDENNRRSKTRLAKEESKLEKEVIKIILSGNTEEALKPNSGQAVTIGEHHICVGYHMEAGSEYRVWEWHGHIMLFDDENGYDPEYIYGNYFERLRVVPEKMKEEEAVMKEEEKPMNSGLKDLIGSSEDGGSGRILHRNMNTGSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JUB2</accession>
    <name>A0A118JUB2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_007079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YTHDF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005087">
        <property type="protein sequence ID" value="KVH90942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JUB2"/>
    <dbReference type="SMR" id="A0A118JUB2"/>
    <dbReference type="STRING" id="59895.A0A118JUB2"/>
    <dbReference type="Gramene" id="KVH90942">
        <property type="protein sequence ID" value="KVH90942"/>
        <property type="gene ID" value="Ccrd_007079"/>
    </dbReference>
    <dbReference type="OMA" id="FMDPTMC"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF99">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN ECT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="6">
        <location>
            <begin position="436"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH90942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="671" mass="73921" checksum="A9BB7345A0B78723" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVS1</accession>
    <name>A0A118JVS1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">11-S seed storage protein, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_004452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 11S seed storage protein (globulins) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004757">
        <property type="protein sequence ID" value="KVH93489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVS1"/>
    <dbReference type="STRING" id="59895.A0A118JVS1"/>
    <dbReference type="Gramene" id="KVH93489">
        <property type="protein sequence ID" value="KVH93489"/>
        <property type="gene ID" value="Ccrd_004452"/>
    </dbReference>
    <dbReference type="OMA" id="RAMMGEM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02243">
        <property type="entry name" value="cupin_11S_legumin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006044">
        <property type="entry name" value="11S_seedstore_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050253">
        <property type="entry name" value="Seed_Storage-Functional"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189">
        <property type="entry name" value="OS03G0336100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189:SF45">
        <property type="entry name" value="OS09G0552500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00439">
        <property type="entry name" value="11SGLOBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0708">Seed storage protein</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="173"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH93489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="340" mass="36806" checksum="45124D2B79C67158" modified="2016-04-13" version="1">METNLVAEKADQTVYEGEGGAYYAWTPSKSPLLSEWKLGAGELILHPLGFALPHFSDSSKIEETVVVIKKGDVMPLPRGQISWWFNGGDTDLTIIFLGETAKAQVVGEMSYFFLSGAQGMLHGFQSDIVAKVFDLNNKEAEDLVSSQPGSLIVKLRKGTEFPNPSEHVKEKVYAAIDTPAADVVVEGGGIINSLTEKEFPVLMGMDLSARFVRLEGKAMLAPSYVADGTGRVIYVAKGSGRIRVVGNEGKPSFDGDVKEGELMVLPQFLAASVIADEGGMELFSVINSSKPTFEQLAGNVSVWKKLSSVVLQSTLNINPELEELFMSKNTQSLMIIPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JVY1</accession>
    <name>A0A118JVY1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_003157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004526">
        <property type="protein sequence ID" value="KVH94779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JVY1"/>
    <dbReference type="STRING" id="59895.A0A118JVY1"/>
    <dbReference type="Gramene" id="KVH94779">
        <property type="protein sequence ID" value="KVH94779"/>
        <property type="gene ID" value="Ccrd_003157"/>
    </dbReference>
    <dbReference type="OMA" id="FQPLYKD"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000434">
        <property type="entry name" value="Aladin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="2">
        <location>
            <begin position="118"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH94779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="454" mass="49436" checksum="F0F65FBED6E7EBAD" modified="2016-04-13" version="1">MCEKGGKFAATSTSPTPPSPTANFNSRSLKNAIVSSARLGYLTAESLSDDQAKETYGKILGVVFSAIPYQLDYPLSQSPDRGVESPVSRLWGLLQAVSYGPLKNLVGSDDERLLPNVDLRCLSWHQKKDILAFVSARNQVTIRDYGDSGEGKDPCVLMNDLQREVKLLEWRPNAGKTLSVACKGGICIWSASYLGNSACMRSGINSGSLSRGSGVRWTLVDFLRSHGDEQISALSWTSASYESSSFTIWDVAQGVGTPIRRGLGSISLLKWSPTGDYFFAAKFDGTFYLWETNTWTSEPWSSTSGFVTGAAWDPDGRMILIAFSESSTLGSIHFATKPPSLDAQLFPVDLPELKSLTNSGGIEKIAWDASGERLAVSYKDGNELYKGLIALYDVKRATLITPSLIGFIRGPGDDPKPLTFSFHDKFKQGPLLSVCWSSGICITYPLMIRSHVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JWK9</accession>
    <name>A0A118JWK9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004365">
        <property type="protein sequence ID" value="KVH96007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JWK9"/>
    <dbReference type="STRING" id="59895.A0A118JWK9"/>
    <dbReference type="Gramene" id="KVH96007">
        <property type="protein sequence ID" value="KVH96007"/>
        <property type="gene ID" value="Ccrd_001911"/>
    </dbReference>
    <dbReference type="OMA" id="AINMPRI"/>
    <dbReference type="OrthoDB" id="625231at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="90" mass="10356" checksum="CBE74B3541A03401" modified="2016-04-13" version="1">MGIFRLRSVVANAKQLVKRQDVPKGYLAVYVGEVQRKRFVVPLSYLDQPLFQDLLRRSEEEFGFNHPMGGLTIPCHEEAFVHLTAQLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JXJ3</accession>
    <name>A0A118JXJ3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_001421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004284">
        <property type="protein sequence ID" value="KVH96491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JXJ3"/>
    <dbReference type="Gramene" id="KVH96491">
        <property type="protein sequence ID" value="KVH96491"/>
        <property type="gene ID" value="Ccrd_001421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH96491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="61" mass="7059" checksum="6DE6ED19D46336B1" modified="2016-04-13" version="1" fragment="single">MTIHSSRKRFRRLTVFINDEARFTLLSRDSQIPHDSADFVEATTFGGSNIDPTAWEEKKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JY10</accession>
    <name>A0A118JY10_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_023776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003813">
        <property type="protein sequence ID" value="KVH98032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JY10"/>
    <dbReference type="STRING" id="59895.A0A118JY10"/>
    <dbReference type="Gramene" id="KVH98032">
        <property type="protein sequence ID" value="KVH98032"/>
        <property type="gene ID" value="Ccrd_023776"/>
    </dbReference>
    <dbReference type="OMA" id="SHNMEER"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH98032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="621" mass="68749" checksum="5D0E542F8ED499C0" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118JZX7</accession>
    <name>A0A118JZX7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding WRKY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_021210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003378">
        <property type="protein sequence ID" value="KVI00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118JZX7"/>
    <dbReference type="STRING" id="59895.A0A118JZX7"/>
    <dbReference type="Gramene" id="KVI00540">
        <property type="protein sequence ID" value="KVI00540"/>
        <property type="gene ID" value="Ccrd_021210"/>
    </dbReference>
    <dbReference type="OMA" id="NSSDHDC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF137">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVI00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="291" mass="33643" checksum="E785EF566CC11D83" modified="2016-04-13" version="1" fragment="single">PNGPNPPYVKKKYTTNPHPQHPHPQARVRTHALQIQTPLARTTSSRSSSSSGIVVEEQEKLYKFWSSRIMEGSERGLASFDLQVNSFSNPIHDHMGFPHFQDHHHHQSQVLRFLPPTLSLPQLSQPPLHTAATTTTTTSTTAAGNFNSDAHMVHRDSWHKEQVGSLDPKSVNEEKCTDDHNSWWRSSSNPEKGRMKMRRKLREPRFCFQTRSDVDVLDDGYKWRKYGQKVVKNSLHPRSYYRCTHTNCRVKKRVERLSEDCRMVITTYEGRHNHSPCDDSNSSEHECFTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K0Y8</accession>
    <name>A0A118K0Y8_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002664">
        <property type="protein sequence ID" value="KVI02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K0Y8"/>
    <dbReference type="STRING" id="59895.A0A118K0Y8"/>
    <dbReference type="Gramene" id="KVI02100">
        <property type="protein sequence ID" value="KVI02100"/>
        <property type="gene ID" value="Ccrd_019620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083:SF25">
        <property type="entry name" value="C-JID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60277" checksum="6B590F8547B9BB6D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K136</accession>
    <name>A0A118K136_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002670">
        <property type="protein sequence ID" value="KVI01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K136"/>
    <dbReference type="STRING" id="59895.A0A118K136"/>
    <dbReference type="Gramene" id="KVI01950">
        <property type="protein sequence ID" value="KVI01950"/>
        <property type="gene ID" value="Ccrd_019773"/>
    </dbReference>
    <dbReference type="OMA" id="TTRRENQ"/>
    <dbReference type="OrthoDB" id="642765at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF181">
        <property type="entry name" value="OS02G0764700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="277" mass="30252" checksum="91A6159168504E14" modified="2016-04-13" version="1">MQRMIKEEATTAGHHQLPLIRHPPWRRLTNDEEATVMVNALKNVMMGGSGSTSVNHQNGYDLRLLPPTEYTTVNGGAAGCSVPVPVSVPETCAICRIKGCLGCNYFKDDMNLNGFGGGGGGGGVGAGGPIKKKKKNYRGVRQRPWGKWAAEIRDPRKAARVWLGTFETAEAAARAYDRAAIEFRGPRAKLNFLFSDYTTSSLPEHNQQQAAPPISRKKPEGNTSRKFELAGEKGKKPITENEFLDATGEEEIQEWMMIMDFNGNSSDSTLSGTVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K256</accession>
    <name>A0A118K256_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate kinase PfkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002327">
        <property type="protein sequence ID" value="KVI03823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K256"/>
    <dbReference type="STRING" id="59895.A0A118K256"/>
    <dbReference type="Gramene" id="KVI03823">
        <property type="protein sequence ID" value="KVI03823"/>
        <property type="gene ID" value="Ccrd_017858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI03823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="443" mass="48459" checksum="BD4C14748C69379B" modified="2016-04-13" version="1" fragment="single">KLGYCAILCHAPPHRADNDSHILYCHHVPDLHLLFFTIRIVNSLLHYLQVSFFTRSSHYSPLFRVNMSSTSTPPETPIVLGVGGVAVDLLATVASYPNPDDKIRSTSMKVQGGGNAGNALTCAARLGLNARLISKVANDAQGRGVLEELQVDGVDVSFFVVMNIAVEENKIYRAMLYHMIRFPKREIHHSPMKTRTCIHTPGSPPMIPSDLSSLTLSSALDGVKLTYFDVRLHETALVVAHEANRRSIPILIDAEKLRDGLDDFLYLSDYVAWTKAPTVPSALVSMLLRLPKVKFVIVTLGADGCIMLERKDGQAEEMDADNLVEQLRQKINSGKAAPTLFLGTAEKIPESELVDTTGAGDAFIGAILYGSYCMSSFGSSNGSPVSLGSSIDAFFRVEAPSDSNGIVVADRVGKSGPGFRIWLFVLVCFFGYFWFDFLLLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2C0</accession>
    <name>A0A118K2C0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin responsive SAUR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_017568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002306">
        <property type="protein sequence ID" value="KVI04127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2C0"/>
    <dbReference type="STRING" id="59895.A0A118K2C0"/>
    <dbReference type="Gramene" id="KVI04127">
        <property type="protein sequence ID" value="KVI04127"/>
        <property type="gene ID" value="Ccrd_017568"/>
    </dbReference>
    <dbReference type="OMA" id="RIAYSNR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI04127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="103" mass="11681" checksum="0CB60D79624340C2" modified="2016-04-13" version="1">MAILMPRIIQAKQILRRSLSNGSSNTYMAIPKGYFAVYVGEQEKKRFVVPVSLLSQPAFQELLYQTEEEFGYIHPMGGLTIPCNEDIFTDLASRIAYSNRVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K2D4</accession>
    <name>A0A118K2D4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002301">
        <property type="protein sequence ID" value="KVI04183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K2D4"/>
    <dbReference type="Gramene" id="KVI04183">
        <property type="protein sequence ID" value="KVI04183"/>
        <property type="gene ID" value="Ccrd_017511"/>
    </dbReference>
    <dbReference type="OMA" id="RIEPMME"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000125">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001050">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g33760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000470">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g66520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001087">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF402">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY, DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="587"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI04183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="637" mass="71249" checksum="A56B0F3F6032E8B8" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K4V9</accession>
    <name>A0A118K4V9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_013483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001230">
        <property type="protein sequence ID" value="KVI08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K4V9"/>
    <dbReference type="STRING" id="59895.A0A118K4V9"/>
    <dbReference type="Gramene" id="KVI08148">
        <property type="protein sequence ID" value="KVI08148"/>
        <property type="gene ID" value="Ccrd_013483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000007">
        <property type="entry name" value="Outer envelope protein 80, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF40">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 36, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="1" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="5">
        <location>
            <begin position="121"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVI08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="396" mass="43939" checksum="DFFAEA3E166B3E5C" modified="2016-04-13" version="1">MLDQQERKEERRGKSAGNPNRISNQNRYKQPISYVFHWQPISYPFRRTSIYPSLLSLPTELVGVPLPRFSSLSKPSEIWDFEWWKKLSDGSSEERPCWQRNSDRGSPLSLIVGSLCIKHPNLFGKSEKLDVLWDKGLSDSNILIAYRKPRPEWLAQHSFVIQHSVSPEIGIHGVPVDNFSRTGSGGVNLCRFSAGLDLDEPGSSNWSSKTSIKFEHVRPVNDDGHSITRDIHGFTVTSSGSCHDSMVVLKQESRFAKANDHSFTRFSLQIEQGIPLMSKWLIFNRFKFAASKGVRAGPGFLLASITGGSIVGDIAPYQAFAIGGLGSVRGYGEGAVGSGRSCLVANTELTFPMNQMLDGALFCDVGSDLGSGRYVPENPNRVEEKPSLISFFIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7C2</accession>
    <name>A0A118K7C2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_009573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. AP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01000020">
        <property type="protein sequence ID" value="KVI12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7C2"/>
    <dbReference type="STRING" id="59895.A0A118K7C2"/>
    <dbReference type="Gramene" id="KVI12016">
        <property type="protein sequence ID" value="KVI12016"/>
        <property type="gene ID" value="Ccrd_009573"/>
    </dbReference>
    <dbReference type="OMA" id="NWAWQPH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000004">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF118">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="465" mass="50956" checksum="8861477BB5D48052" modified="2016-04-13" version="1">MLDLNMSFVHEDERMAFRGEVEESATSNSSVINAEGCNSSNAGEGDDDSISAAMDGDSFRCFNFDILKVGDTAALPSNGNSNSNDEDRMSQTQSEFVTRTLFPVSHGEGGGGGRLNQGQQVNSLLLFPNNNELQDTRMIQVPQQKPTVQLNQVGKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVDADINFNLSDYEDDMNQIKNLSKEDFVHILRRHSSGFSRGNSKYRGGVTVQKCGGSEAQMGEFLGKKAHEKAAIKINGGEAVTNFEANTYKGETVSASHCGSDHNLDLNLGISTPSCLGKCSSRTENLEHMQLNHGLHDIRRLQVENPATMTLRGLPVISEHGQSWTGMYPTFFPSYEVGATYSRFVGGSSQGPSNWAWQFHGQSRPPTTLFTAASSGFPAPTAATNSPHHHYQIRPRPSPPPAPPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A118K7N0</accession>
    <name>A0A118K7N0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_009043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01000001">
        <property type="protein sequence ID" value="KVI12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A118K7N0"/>
    <dbReference type="STRING" id="59895.A0A118K7N0"/>
    <dbReference type="Gramene" id="KVI12498">
        <property type="protein sequence ID" value="KVI12498"/>
        <property type="gene ID" value="Ccrd_009043"/>
    </dbReference>
    <dbReference type="OMA" id="LKPHPWS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF77">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="460" mass="52471" checksum="FD8A3093A09E8FFB" modified="2016-04-13" version="1">MASLPASGVREPTGTTLAAQTLPNEMNDMKIRDDRTISYMAERVVGHGSFGVVFQAKCLETGEAVAIKKVLQDKRYKNRELQTMRILDHPNVVALKHCFFSTTENEQLYLNLVLEYVPETVHRVIKHYNKMNQRMPMIYVKLYGYQIFRALAYIHGSIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDIWSGGCVLAELLLGQITLVHNYENGCDNQRNKLMGHTTYVALIMAFIDLMGHKTYLLVVFIDLMGHTTYLLVVFIDLMKAYGRLPIQCNFGGVDREVEDQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEYKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRSTALEALIHPFFDELRDPATRLPNGRFLPPLFNFKPHELKGVAVEMLTKLVPEHARKHCAFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124S5L3</accession>
    <name>A0A124S5L3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_025592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006551">
        <property type="protein sequence ID" value="KVH72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124S5L3"/>
    <dbReference type="STRING" id="59895.A0A124S5L3"/>
    <dbReference type="Gramene" id="KVH72116">
        <property type="protein sequence ID" value="KVH72116"/>
        <property type="gene ID" value="Ccrd_025592"/>
    </dbReference>
    <dbReference type="OMA" id="NEAWADP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044821">
        <property type="entry name" value="At1g28695/At4g15970-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038:SF38">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="406" mass="47054" checksum="00B6217EE9104123" modified="2016-04-13" version="1">MRLESPERRRRTAIVRLRRSSQAAIYSSATCLFSGEMLRVCYWEIRPSFVLHRLRIATLFVVVFVFSYLVFDRAFDSGRIRLPEYFVPSTRIFPSSLFDSLPDSADTNLETVLKDASMQDHTVILTTLNEAWADPENSILDLFLESFRIGYQTSKLLNHLVIIALDQKAFMSCKRVHTHCFALITEGADLSREAYFMTPDYLKMMWLRIDFLRSVLEMGYNFLFTDADVMWFRDPFPHFYPNADFQIACDHYSGNSTDVESNHPNGGFSFVRSNVRSIEFYKYWYSSREMYPGLHDQDVLNNIKFDSFLIDIDLQLRFLSTAYFGGFCEPSKDLNKVCTMHANCCVGLGNKVHDLRIMLQDWKNFMALPPSMKISQTLTWSPPDNCTLALRRHFGLSGNGTRVHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAP4</accession>
    <name>A0A124SAP4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_024473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LEKV01005552">
        <property type="protein sequence ID" value="KVH88137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAP4"/>
    <dbReference type="STRING" id="59895.A0A124SAP4"/>
    <dbReference type="Gramene" id="KVH88137">
        <property type="protein sequence ID" value="KVH88137"/>
        <property type="gene ID" value="Ccrd_024473"/>
    </dbReference>
    <dbReference type="OMA" id="YWVAGDN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1061">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH88137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="582" mass="66401" checksum="683074B2CAC865E9" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SAT9</accession>
    <name>A0A124SAT9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_026514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005372">
        <property type="protein sequence ID" value="KVH88555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SAT9"/>
    <dbReference type="STRING" id="59895.A0A124SAT9"/>
    <dbReference type="Gramene" id="KVH88555">
        <property type="protein sequence ID" value="KVH88555"/>
        <property type="gene ID" value="Ccrd_026514"/>
    </dbReference>
    <dbReference type="OMA" id="ACDKNRI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602:SF4">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH88555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="342" mass="37720" checksum="7C3F82201F861ECF" modified="2016-04-13" version="1">MAEQQEGYQIDLGNLTAFDPQHQFQSIPDKREDLVKECITHATKLIQAVADSLFSLPSTEDASGPIVPLPQPTTKLPREKPLPKPAPPTKWEVFAKKKGIQNRKKDKLVFDEQTSSWKRRYGYDRVNDDNDVPIIEAKMTDEPGVDPFATRRSEKKQRVEKQEKNRLYNLKEAAKVGALPSHVQLAATALPITGTQAAPRKVSKDELQNVAGMAGTSTASGGKFDKKLAGEKPPKHDKKYRKFLPVVEGSGMGSLEKQQTDKILNKLMAKNSHEIFNVSKAVDMYNVKSDKKRRNQQGKSSAMSSKLKVKKSPYKNASKGSSKKGGSSSKGKSGSSSKGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SB27</accession>
    <name>A0A124SB27_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005245">
        <property type="protein sequence ID" value="KVH89320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SB27"/>
    <dbReference type="STRING" id="59895.A0A124SB27"/>
    <dbReference type="Gramene" id="KVH89320">
        <property type="protein sequence ID" value="KVH89320"/>
        <property type="gene ID" value="Ccrd_008693"/>
    </dbReference>
    <dbReference type="OMA" id="YLEVEWI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04038">
        <property type="entry name" value="C2_ArfGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000190">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044518">
        <property type="entry name" value="ARF_GAP_AGD11/12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220:SF19">
        <property type="entry name" value="ARF GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="108"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="30759" checksum="E9EAACC3858A3006" modified="2016-04-13" version="1" fragment="single">SPPLGVFVCLKCCGVHRTLDPSISKVLSVTLDEWTDEEIDAMVEVGGNSSANSIYEGHFPEGVTKPGPDASHEQRAKSKYELQDFLKPSLKISSTNAKRNTSERANSLPATSSIQMPEGMEGAIGMLKITILQGANLAVRDMLSSDPYVVLTLGEQAQTTVQKSNLNPIWNEELILSVRQDCGPVKLQVFDYDTFSADDIMGEAEIDIQPMLTSALAYGEASMFGDMQIGKWLKSHDNALLEDSTVNIVDGKIKQEVSLQLQNVESGIIYLEVEWIPPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SBC2</accession>
    <name>A0A124SBC2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP citrate synthase</fullName>
            <ecNumber evidence="3">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_007777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterooctamer of 4 alpha and 4 beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005114">
        <property type="protein sequence ID" value="KVH90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SBC2"/>
    <dbReference type="STRING" id="59895.A0A124SBC2"/>
    <dbReference type="Gramene" id="KVH90172">
        <property type="protein sequence ID" value="KVH90172"/>
        <property type="gene ID" value="Ccrd_007777"/>
    </dbReference>
    <dbReference type="OMA" id="RFIEICT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000136">
        <property type="entry name" value="ATP-citrate synthase beta chain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="13">
        <location>
            <begin position="173"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="618" mass="66949" checksum="9C45216C9A14E371" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCV8</accession>
    <name>A0A124SCV8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_002909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004443">
        <property type="protein sequence ID" value="KVH95022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCV8"/>
    <dbReference type="Gramene" id="KVH95022">
        <property type="protein sequence ID" value="KVH95022"/>
        <property type="gene ID" value="Ccrd_002909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH95022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="274" mass="31586" checksum="FE56CB0535BDD052" modified="2016-04-13" version="1">MESPIWPESLPINRKKAIQELTQGQEWTDKLREILQQSENIESDSASLDGVVDRILGMFDNTLSIMGSRTSNEPLQFLTNYLQTSYSFDEQKSKTSDLQSLCSLELDERKLRKSDETFSLQTSYLESPRSSDENKSKKYDETSRMVIPVKMKRGCHKRDTSILLNFKAKELTGNKQVNHFFQPMKHEPNEGSPSLGNQRDNQSTPSDDCLLWDLIMKVPQVPLESVSMSVGLDHEIYLWSEHGDMTSSYSSMASTERHEMDYMFESNDFKDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SCW2</accession>
    <name>A0A124SCW2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_002852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LEKV01004400">
        <property type="protein sequence ID" value="KVH95067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SCW2"/>
    <dbReference type="STRING" id="59895.A0A124SCW2"/>
    <dbReference type="Gramene" id="KVH95067">
        <property type="protein sequence ID" value="KVH95067"/>
        <property type="gene ID" value="Ccrd_002852"/>
    </dbReference>
    <dbReference type="OMA" id="MPFCIKA"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043617">
        <property type="term" value="P:cellular response to sucrose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009646">
        <property type="term" value="P:response to absence of light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF14">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVH95067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="505" mass="55315" checksum="ECE3FCBF37A589C0" modified="2016-04-13" version="1">MLLSRRILSGRSWNSGRRCLCYLTSIPPTTVVKPPTIAQFSSAALPFSKAKFDCSYKLNNCYNVMGHYFSTNALDSQAVDGVVDVPLAQTGEGIAECELLKWFVHEGDQVEEYQPLCEVQSDKATIEITSRYKGRVFKVLHIPGDIVKVGETLLKLTVDDSPVAFAVSETLLSSDTSNSDTSNSDDLKPELRKTQQGGALSTPAVRVLAKQHGIDIDDVLGTGKDGRVLKEDILKYSVEKGIITDKPVFNPSSIEPMSGPEEKLHEIAESLYQDKILSLRGYQRAMVKSMTAAASIPHFHYVEEINFDGLVELKAAFQKENSDPDVKFTFLPVMIKSLSMALTTHPIVNSTFNLEKYEVTLKGSHNIGIAMATPAGLVVPNIKNVQSLSILEITKELSRLQKLAMANKLPPSDISGGTITLSNIGSIGGKFGSPLINVPEVAIIALGRVQKVAHFRDDGTVYPVSLMTVDVAADHRILDGANVALFCKEWKLFLEKPELLLLHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD02</accession>
    <name>A0A124SD02_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_002510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004390">
        <property type="protein sequence ID" value="KVH95380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD02"/>
    <dbReference type="Gramene" id="KVH95380">
        <property type="protein sequence ID" value="KVH95380"/>
        <property type="gene ID" value="Ccrd_002510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH95380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="14990" checksum="60253D7C3C199DE8" modified="2016-04-13" version="1" fragment="single">MVIFHCLASSCSGHWIWYLDELSSRWLSKVSHAASYGPWLRDLSNIGYWVSGGSKEQLYIVMDVFGHAVLGFGGDPYLYCLGVQRVSTPRSWFLVCKESKCGYPAVNASYYDLSFHPVSSNNDCKLYKNSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD53</accession>
    <name>A0A124SD53_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_002034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPR family. PCMP-E subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004374">
        <property type="protein sequence ID" value="KVH95875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SD53"/>
    <dbReference type="STRING" id="59895.A0A124SD53"/>
    <dbReference type="Gramene" id="KVH95875">
        <property type="protein sequence ID" value="KVH95875"/>
        <property type="gene ID" value="Ccrd_002034"/>
    </dbReference>
    <dbReference type="OMA" id="AICWTSV"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000690">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000285">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001535">
        <property type="entry name" value="Putative pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF525">
        <property type="entry name" value="EMB2261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH95875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="609" mass="68563" checksum="F026B73A13CFEC68" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SD63</accession>
    <name>A0A124SD63_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_001993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004371">
        <property type="protein sequence ID" value="KVH95932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A124SD63"/>
    <dbReference type="Gramene" id="KVH95932">
        <property type="protein sequence ID" value="KVH95932"/>
        <property type="gene ID" value="Ccrd_001993"/>
    </dbReference>
    <dbReference type="OMA" id="LERFCMQ"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF46">
        <property type="entry name" value="PROTEIN ACCELERATED CELL DEATH 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="8">
        <location>
            <begin position="61"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH95932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="299" mass="33099" checksum="482A9962A8E1ABB1" modified="2016-04-13" version="1" fragment="single">MSPSGVHPQKLLERFCMQRLTWTALMSAGTPRALVGNKDILSSKKHDLSGKDERHYVDYSKDRVNTLLLVATLVATVTFAAGFTMPGGYVXTEPKXGQAALLHKLLLQTFVICDTIALYSAIMVAVTLIWAQLGDLTLVVNALKFALPLLGLSLTTMSVAFMVGVFLVVADLTWLANFVLIFGIISLANMLTLFIPLCLPYTSTSLVLRYITYYPFRLLVLASGSSDDRQIKEHLLKDVSIHIFGEGTKQVQIWSWIRMQRIGSTNAEELRKKESSMCEVGSIAPRAYRKRAEVSTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SF65</accession>
    <name>A0A124SF65_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine alpha-hairpin motif superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_019502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002660">
        <property type="protein sequence ID" value="KVI02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SF65"/>
    <dbReference type="SMR" id="A0A124SF65"/>
    <dbReference type="STRING" id="59895.A0A124SF65"/>
    <dbReference type="Gramene" id="KVI02266">
        <property type="protein sequence ID" value="KVI02266"/>
        <property type="gene ID" value="Ccrd_019502"/>
    </dbReference>
    <dbReference type="OMA" id="TQMENAG"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="113" mass="12503" checksum="06E082736B9013EA" modified="2016-04-13" version="1">MATQMENAGNEVSCPWKSTAYCLYSAISMVNTGELVIMSGLQTQDFPSTLRLTKTPKDQGPTVSESKPKKKICCACPDTKKLRDECIVEHGETACSKWIEAHRLCLRSEGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SFD6</accession>
    <name>A0A124SFD6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_018816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002619">
        <property type="protein sequence ID" value="KVI02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SFD6"/>
    <dbReference type="STRING" id="59895.A0A124SFD6"/>
    <dbReference type="Gramene" id="KVI02896">
        <property type="protein sequence ID" value="KVI02896"/>
        <property type="gene ID" value="Ccrd_018816"/>
    </dbReference>
    <dbReference type="OMA" id="WESELLM"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="386" mass="41003" checksum="3FE1942B0AB49ABC" modified="2016-04-13" version="1">MAEGTRTRVLEDSVKTVQEAQVSMQKHLDGVVSAIDSLQKTMNELLLRLAAPAIASGVGALAPTLGTIVPVIGAGGFAAVASAAGSVAGSVAVAASFGAAGAGLTGTKMAKRTGSVDEFEFKAIGENHNQGRLAVEIMVSGFVFEEDDFLRPWEGQTDHSERYALQWESEHLIAVSTAIQDFITSKLALELMKQGAMMTVLSSLVAALALPATLLTITDIIDSKWSIAVDRSDKAGKLLTEVLINGLQGNRPVTLVGFSLGARAIFKCLQHLAETDHSGVVERVVLLGAPVAIKDENWEAVRKVVSGRLVNAYSTNDWMLGVAFRASLLSQGLAGIQPVDVPGIENVDVTEAIEGHSSYLWGTREILDRLDLDGYYPVFKIANTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A124SG41</accession>
    <name>A0A124SG41_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AMP-binding, conserved site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_016489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01001886">
        <property type="protein sequence ID" value="KVI05191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A124SG41"/>
    <dbReference type="STRING" id="59895.A0A124SG41"/>
    <dbReference type="Gramene" id="KVI05191">
        <property type="protein sequence ID" value="KVI05191"/>
        <property type="gene ID" value="Ccrd_016489"/>
    </dbReference>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106286">
        <property type="term" value="F:(E)-caffeate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050563">
        <property type="term" value="F:trans-feruloyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05904">
        <property type="entry name" value="4CL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF413">
        <property type="entry name" value="PEROXISOMAL OPC-8:0-COA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="45"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVI05191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="549" mass="60060" checksum="153A6666A4EE5395" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103D5E4</accession>
    <name>A0A103D5E4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_024309</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Na(+)(in) + H(+)(out) = Na(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01012773">
        <property type="protein sequence ID" value="KVD98098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103D5E4"/>
    <dbReference type="STRING" id="59895.A0A103D5E4"/>
    <dbReference type="Gramene" id="KVD98098">
        <property type="protein sequence ID" value="KVD98098"/>
        <property type="gene ID" value="Ccrd_024309"/>
    </dbReference>
    <dbReference type="OMA" id="IMILMSY"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF159">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="14">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVD98098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="80" mass="9176" checksum="A230840F4C3EC8A0" modified="2016-04-13" version="1" fragment="single">MILMAYLSYILAEVFGLSGILTVFFCGIVMSHYAWHNVTMNSQVTTKHAFATMSFIAEIFIFMYVGMDSLDMGKWRFVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103RLK3</accession>
    <name>A0A103RLK3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Extracellular solute-binding protein, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_026262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007771">
        <property type="protein sequence ID" value="KVG70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103RLK3"/>
    <dbReference type="Gramene" id="KVG70065">
        <property type="protein sequence ID" value="KVG70065"/>
        <property type="gene ID" value="Ccrd_026262"/>
    </dbReference>
    <dbReference type="OMA" id="WITLVCA"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="129"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVG70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="483" mass="54780" checksum="1E2682024CCBD3AA" modified="2016-04-13" version="1">MEHQNHIVSLVFLVAMLCVCFMVDFVQASILVTXEKGXTEEKYTKLRSTKTMTSTAIKDASSRKRRSIQEQGDTGQVDVCAGFLFLIYFSFGLCFKMKKKMTDERDEAKRNIIGPXWKIKKQGKGPCPTLVVWVPKKTGFTEFVKVNXQLKVEGGFSVATCXAVAGDVTVRGARAQYVDFTIPYLSSEVYMLVHATHEWNQTLWTFVRPFTKRLWITLLGACIFIGLAXAILEYRVSNPKFTSPFYQKLIMVIWFPISTFFFHEGKILNRCSKIVLVIWLSMIFIVVQIFTATLSSWLTLDQLRPRLPSSFENVGYQDGSFLKDLIAQKSNYSGRNIVPLKGVEEFKNALSNGSVNAIYDELPYIQLFLAKYGSDYMKFGPINQESGIAFAFPRGSPLLQNFSRAVINVTESELMMEMKTKYLGFSTLDKSQQNQALPQSLDVQSFIGLFIFMGSVTIVAVIWSEISLRRRNNKILPLTSTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103SPA7</accession>
    <name>A0A103SPA7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_026126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01007472">
        <property type="protein sequence ID" value="KVG89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103SPA7"/>
    <dbReference type="Gramene" id="KVG89788">
        <property type="protein sequence ID" value="KVG89788"/>
        <property type="gene ID" value="Ccrd_026126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVG89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="63" mass="6871" checksum="6DB39A87ADCBA1C9" modified="2016-04-13" version="1">MVDDCSGVKIAPMVRWVSTALGSTDMLGLPSSFASFDYFLLLVPCFAKLFLSECPICCMLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103UMQ9</accession>
    <name>A0A103UMQ9_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEK, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_025802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006894">
        <property type="protein sequence ID" value="KVH38510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103UMQ9"/>
    <dbReference type="STRING" id="59895.A0A103UMQ9"/>
    <dbReference type="Gramene" id="KVH38510">
        <property type="protein sequence ID" value="KVH38510"/>
        <property type="gene ID" value="Ccrd_025802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH38510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="128" mass="14118" checksum="A1B9540F91CA00FA" modified="2016-04-13" version="1">MVSDSELVGRLREFLSTSDLTTTTRPSIRRQLEQDFEIDLKNKKAFIREQVDLYLESQQQNEEDEEEEAAMAKCGDLGTKISEDILFGINFLTFCVKDFGSSGMSSIGSPLGASIAGSKSVVHFVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103VLU5</accession>
    <name>A0A103VLU5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5, heme-binding site-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_025681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01006703">
        <property type="protein sequence ID" value="KVH56143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103VLU5"/>
    <dbReference type="STRING" id="59895.A0A103VLU5"/>
    <dbReference type="Gramene" id="KVH56143">
        <property type="protein sequence ID" value="KVH56143"/>
        <property type="gene ID" value="Ccrd_025681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF41">
        <property type="entry name" value="GEO08203P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH56143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="139" mass="15764" checksum="131B0801E62124ED" modified="2016-04-13" version="1">MFKHPTQPENQSGGWMACEKHLEISSELAHPTLKNSVSSPFMNTASLTYTMFEVKKHNSADSAWIVVHGHIYDYTKFLKDHPGGSDNIHINAGIDCTKEFDAIHSDKAKKLLTKQTIRFNWVSPVQRHRFGKGCHRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103X5G3</accession>
    <name>A0A103X5G3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Starch synthase, chloroplastic/amyloplastic</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_025454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Plastid</location>
            <location evidence="9">Chloroplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Plastid</location>
            <location evidence="9">Amyloplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01006381">
        <property type="protein sequence ID" value="KVH84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103X5G3"/>
    <dbReference type="STRING" id="59895.A0A103X5G3"/>
    <dbReference type="Gramene" id="KVH84541">
        <property type="protein sequence ID" value="KVH84541"/>
        <property type="gene ID" value="Ccrd_025454"/>
    </dbReference>
    <dbReference type="OMA" id="ATECHPW"/>
    <dbReference type="UniPathway" id="UPA00152"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000073">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000090">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825:SF3">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="3 9" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Starch synthase catalytic" evidence="11">
        <location>
            <begin position="85"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="396"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="641" mass="70274" checksum="D580720A051B1D2B" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBN0</accession>
    <name>A0A103XBN0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_024975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LEKV01005877">
        <property type="protein sequence ID" value="KVH87737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBN0"/>
    <dbReference type="STRING" id="59895.A0A103XBN0"/>
    <dbReference type="Gramene" id="KVH87737">
        <property type="protein sequence ID" value="KVH87737"/>
        <property type="gene ID" value="Ccrd_024975"/>
    </dbReference>
    <dbReference type="OMA" id="WPFISMI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13985">
        <property type="entry name" value="STKc_GAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000349">
        <property type="entry name" value="probable serine/threonine-protein kinase DDB_G0280111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KVH87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="662" mass="73646" checksum="4F3BAB1B0A118982" modified="2016-04-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBS7</accession>
    <name>A0A103XBS7_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YGGT family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_024874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005803">
        <property type="protein sequence ID" value="KVH87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBS7"/>
    <dbReference type="STRING" id="59895.A0A103XBS7"/>
    <dbReference type="Gramene" id="KVH87814">
        <property type="protein sequence ID" value="KVH87814"/>
        <property type="gene ID" value="Ccrd_024874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010020">
        <property type="term" value="P:chloroplast fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219:SF14">
        <property type="entry name" value="PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="YLMG HOMOLOG PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="CCB3_YggT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007118669" description="YGGT family protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30763" checksum="2A73B6BDFDEEC325" modified="2016-04-13" version="1" fragment="single">WESAYIIWLISIHLQILSSPLPPFQRRKHRKKTMHSSSSRRKDSCDNDPAANSVIVGLPLSSLLFFKSTTTNHFQRIVTESSNTLIRNLRNSIHKCLNFLQNPLFTKWHSEYHNFCQINCRKQRNLKSLSNHDFAAIIPGDSVAGLVVSNGVLNFLNIYNTLLVVRLVLTWFPNTPPAIVSPLSTLCDPYLNIFRGVIPPLGGTLDLSPILAFLVLNALTSTASALPAELPVPSTDQKGSSRPSFHTALSHLTSSQKKWMKRFSTNRSSDSSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBS8</accession>
    <name>A0A103XBS8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005802">
        <property type="protein sequence ID" value="KVH87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF585">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="785" mass="89363" checksum="2218A59C1681274A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XBY7</accession>
    <name>A0A103XBY7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_024766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005707">
        <property type="protein sequence ID" value="KVH87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XBY7"/>
    <dbReference type="STRING" id="59895.A0A103XBY7"/>
    <dbReference type="Gramene" id="KVH87921">
        <property type="protein sequence ID" value="KVH87921"/>
        <property type="gene ID" value="Ccrd_024766"/>
    </dbReference>
    <dbReference type="OMA" id="FGKVESW"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000200">
        <property type="entry name" value="Outer arm dynein light chain 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000505">
        <property type="entry name" value="Outer arm dynein light chain 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF37">
        <property type="entry name" value="OUTER ARM DYNEIN LIGHT CHAIN 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVH87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="636" mass="70189" checksum="F9E936CCB07B4B7F" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XCK4</accession>
    <name>A0A103XCK4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_024361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005497">
        <property type="protein sequence ID" value="KVH88232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XCK4"/>
    <dbReference type="STRING" id="59895.A0A103XCK4"/>
    <dbReference type="Gramene" id="KVH88232">
        <property type="protein sequence ID" value="KVH88232"/>
        <property type="gene ID" value="Ccrd_024361"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925139at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34555:SF8">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34555">
        <property type="entry name" value="INTEGRAL MEMBRANE HEMOLYSIN-III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="248" mass="27732" checksum="95CB284B230A9F9E" modified="2016-04-13" version="1">MVEQMVSSNLSKYGLGNCATIMTSSDSQPVPTMRDVQNDNKNGPFDNSALQKDEAVTQPFQAKSPPGSTSNNNNVNRNLVYARRKSDAELSNSRTSDKNRISSYQQLGDQNHIPHTEAKIKANDSVPSFSRTPANSAAARIRNCENEQSVILNSPAMDNWNARFVQLQKYLKQCDSSNPEVYLQKVRSFSTDECSRRAVELERRAIQLMLEEGREIQRVKDLNVLGKSAANHPLLRPMAAVFKSEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XE92</accession>
    <name>A0A103XE92_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_008927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005312">
        <property type="protein sequence ID" value="KVH89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XE92"/>
    <dbReference type="Gramene" id="KVH89093">
        <property type="protein sequence ID" value="KVH89093"/>
        <property type="gene ID" value="Ccrd_008927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="227" mass="26146" checksum="82DE66E628E00C0A" modified="2016-04-13" version="1">MTEHVFQTESSWESSTAERQKSFDIGKEEQVQETSKAKKEVVRSQICSVYFPLQKKDPFSPLSKMMNMKPGRGTIDPLTPNRGLFLSTLGSHQPTIIRVATDLRRSEHRYARLLSCLRTGITRQLVRLEQHCMRTYYPYSRTRGETTSRSTYYSPRIKIFFLVVDTGKTQPDDVCWLVVRGLLVPAYPKGRQFPLTQSTEIPRNPWWISPTTQQQCGIFFSSVGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFJ6</accession>
    <name>A0A103XFJ6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aluminum-activated malate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_008269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aromatic acid exporter (TC 2.A.85) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005150">
        <property type="protein sequence ID" value="KVH89729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFJ6"/>
    <dbReference type="STRING" id="59895.A0A103XFJ6"/>
    <dbReference type="Gramene" id="KVH89729">
        <property type="protein sequence ID" value="KVH89729"/>
        <property type="gene ID" value="Ccrd_008269"/>
    </dbReference>
    <dbReference type="OMA" id="MEMEDPI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH89729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="542" mass="60157" checksum="E04784C0A3897769" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XFS3</accession>
    <name>A0A103XFS3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_008151</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005133">
        <property type="protein sequence ID" value="KVH89849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XFS3"/>
    <dbReference type="STRING" id="59895.A0A103XFS3"/>
    <dbReference type="Gramene" id="KVH89849">
        <property type="protein sequence ID" value="KVH89849"/>
        <property type="gene ID" value="Ccrd_008151"/>
    </dbReference>
    <dbReference type="OMA" id="MTSLCSW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000104">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000335">
        <property type="entry name" value="Serine/threonine-protein kinase MHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="120"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVH89849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="576" mass="64482" checksum="47A1E6416C4AF84D" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XGS1</accession>
    <name>A0A103XGS1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Delta(14)-sterol reductase</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ccrd_007523</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="17">Steroid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01005102">
        <property type="protein sequence ID" value="KVH90465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XGS1"/>
    <dbReference type="STRING" id="59895.A0A103XGS1"/>
    <dbReference type="Gramene" id="KVH90465">
        <property type="protein sequence ID" value="KVH90465"/>
        <property type="gene ID" value="Ccrd_007523"/>
    </dbReference>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000011">
        <property type="entry name" value="Delta(14)-sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KVH90465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="357" mass="40736" checksum="DA840036AE7DE1B0" modified="2016-04-13" version="1">MDFSSLLNSFIPSWNSVGLLLGFFSYLGIAGSILPGKLVPGASLADGTRLHYRCNVIGAWMDYVSPTAISDRGCELLSTTFIFSVVATLLLYVAGCKSSDRSSSLKPHITGNIIDDWWFGIQLNPNFMGVDLKFFFVRAGMMGWLLINLSVLAKSFQDANLSHSMILYQLFCVIYIMDYFFYEEYMTSTWDIIAERLGFMLVFGDLVWIPFTFSIQGWWLLNNKVDLTIAAVIANCCVFVIGYVVFRGANKQKHDFKKNPKALIWGRPPNVIGGKLLVSGYWGIARHCNYLGDLLLALSFSLPCGMSSPVPYFYPIYLLILLIWRERRDEARCAEKYKDVWEKYRRAVPWRILPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XHE7</accession>
    <name>A0A103XHE7_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ccrd_007218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005095">
        <property type="protein sequence ID" value="KVH90768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XHE7"/>
    <dbReference type="STRING" id="59895.A0A103XHE7"/>
    <dbReference type="Gramene" id="KVH90768">
        <property type="protein sequence ID" value="KVH90768"/>
        <property type="gene ID" value="Ccrd_007218"/>
    </dbReference>
    <dbReference type="OMA" id="KKFFMQN"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19907">
        <property type="entry name" value="DSRM_AtDRB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19908">
        <property type="entry name" value="DSRM_AtDRB-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000036">
        <property type="entry name" value="Double-stranded RNA-binding protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044450">
        <property type="entry name" value="AtDRB-like_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044451">
        <property type="entry name" value="AtDRB-like_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031:SF26">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KVH90768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="364" mass="40269" checksum="3205596FDFFB0B1F" modified="2016-04-13" version="1">MYKNQLQELAQRSCFNLPSYTCIREGPDHAPRFKAVVNFNGDSFESPNYFSTLRQAEHAAAEVALCSLSSQSLAARILDETGVYKNLLQEISQRVGAPLPRYTTYRSGLGHLPVFTGMVELAGITFTGEHAKNKKQAEKNAAMAAWSSLKQLAKQDASSSSEPENSDEQEQIRIARALLNYRLKQKIGTANYSDLPIPFQKKFTTPAPRPPSPQRPPLTTSKILPLFYRKAVPPMTTQNRPISPAPHEPSSSSSPHQNHPIRPPHFPAASPSPYISLPQVHRYRLPHQGLAPPVTMRTAVPVFSAPPMPPSPNRQVMQPRPVKIAPPICIRQAVPVFSAPPVKKDEPSNKNECEAVKCLDNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XI23</accession>
    <name>A0A103XI23_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01005074">
        <property type="protein sequence ID" value="KVH91138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XI23"/>
    <dbReference type="Gramene" id="KVH91138">
        <property type="protein sequence ID" value="KVH91138"/>
        <property type="gene ID" value="Ccrd_006849"/>
    </dbReference>
    <dbReference type="OMA" id="DSRFGMI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF246">
        <property type="entry name" value="3-ALPHA-(S)-STRICTOSIDINE BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="83" mass="9768" checksum="8EA3F6E745FA0246" modified="2016-04-13" version="1">MDSFEWQSGYDSRFGMIYVDYANNLQRYPKNSAIWFKKFLFETKVGVSKRTLMDGEEEDEVNNMVFEAEKATEVIPKLKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ16</accession>
    <name>A0A103XJ16_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">CTLH, C-terminal LisH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ccrd_006353</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004915">
        <property type="protein sequence ID" value="KVH91638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ16"/>
    <dbReference type="STRING" id="59895.A0A103XJ16"/>
    <dbReference type="Gramene" id="KVH91638">
        <property type="protein sequence ID" value="KVH91638"/>
        <property type="gene ID" value="Ccrd_006353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF467">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="20">
        <location>
            <begin position="257"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="20">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="584"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="20">
        <location>
            <begin position="890"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KVH91638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1119" mass="129908" checksum="F9823C86106534E3" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XJ95</accession>
    <name>A0A103XJ95_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">APO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_006200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004905">
        <property type="protein sequence ID" value="KVH91761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XJ95"/>
    <dbReference type="STRING" id="59895.A0A103XJ95"/>
    <dbReference type="Gramene" id="KVH91761">
        <property type="protein sequence ID" value="KVH91761"/>
        <property type="gene ID" value="Ccrd_006200"/>
    </dbReference>
    <dbReference type="OMA" id="RNATHVW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023342">
        <property type="entry name" value="APO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05634">
        <property type="entry name" value="APO_RNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51499">
        <property type="entry name" value="APO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APO" evidence="2">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="APO" evidence="2">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH91761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="354" mass="40050" checksum="BA50804AAB5A2BF2" modified="2016-04-13" version="1" fragment="single">MHRRYLSSTIIVPFNYLKKLQINPTHRLGPSRTLTVETTKEPDANGDHLYADIPKPAKSKSERKPYLTPMKILVRRAKQEREARKAQPCKLLEEPPGNGLLVPELVGVAHQVYRARESVLLGLSKLVKAIPVLRCRHCFEVHIGPVGHEIRTCTGPKSGLRNATHVWRRGRVHDVIYFPKCFHLYDRVGKPRIIHNESRAVKQLPAIVELCIQAGLNLENYPTKRRTRPVYSIEGRIVDFDSTPSELATMTLDSWFEMISGAKKMMERYKVHTCGYCPEVQVGPKGHKVRMCKASKHQSRNGMHAWQEATIFDLVGPNYVWHVADPSGSLLSNGLKRYYGKAPAVVELCVQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XK74</accession>
    <name>A0A103XK74_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like calcium-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_005757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004834">
        <property type="protein sequence ID" value="KVH92209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XK74"/>
    <dbReference type="Gramene" id="KVH92209">
        <property type="protein sequence ID" value="KVH92209"/>
        <property type="gene ID" value="Ccrd_005757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like calcium-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="5">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVH92209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="149" mass="16889" checksum="95D718778265A7F6" modified="2016-04-13" version="1">MLTFPLYLDINECHYPEKFPCYGTCVNTVGNYTWKCKEGYSGDAKIRDGCRRKPFHPLVLYIASGKYPTYETYRLVNATDLAKSGCDGRYTDECKNVEKFPCYETCANTPGNYTCKCKRGYSGDAKIHDGCRHKPFPLLLLSSGNPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLL3</accession>
    <name>A0A103XLL3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphotransferase</fullName>
            <ecNumber evidence="9">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_004994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LEKV01004800">
        <property type="protein sequence ID" value="KVH92988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLL3"/>
    <dbReference type="STRING" id="59895.A0A103XLL3"/>
    <dbReference type="Gramene" id="KVH92988">
        <property type="protein sequence ID" value="KVH92988"/>
        <property type="gene ID" value="Ccrd_004994"/>
    </dbReference>
    <dbReference type="OMA" id="TEYRECL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF89">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="11">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="12">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="12">
        <location>
            <begin position="266"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVH92988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="367" mass="39744" checksum="0B3B19A796094149" modified="2016-04-13" version="1">MGKVAMGVAVIGAATICALIVRHRMRSSGRWSKVAEMIKELEDKCDTPNAKLKQIADAMAVEMHAGLASEGGSKLKMLISYVDNLPTGDEEGVYYALDLGGTNFRVLRVQLAGKSGIKSQEFAEVSIPPQLMFHLLPGRQRELGFTFSFPVMQLSVASGELMRWTKGFSIDDMVGQDVVAELTQAMKRQAGGRYDNKDVAIAVILGTGSNAAYVERAQAIPKWHGPPPKSGEMIFEKMISGMYLGEVLRRVLYRMADEAALFGDTVVVELCNIIATRGARLAAAGVLGILKKLGRDIEEMPETVIAMDGGLYEHYTEYSKCMGNTLHELVGDEVSKRIKLIHSNDGSGIGAALLAASHSQYLEVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XLR0</accession>
    <name>A0A103XLR0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily domain, general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_004873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004796">
        <property type="protein sequence ID" value="KVH93080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XLR0"/>
    <dbReference type="Gramene" id="KVH93080">
        <property type="protein sequence ID" value="KVH93080"/>
        <property type="gene ID" value="Ccrd_004873"/>
    </dbReference>
    <dbReference type="OMA" id="HEYRTHL"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH93080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52049" checksum="CF2CC7A4F957C000" modified="2016-04-13" version="1">MGVSMNLVTYLRGRLHLSSSESANIVTNFMGSLNLLALFGGFLADAKLGRYMAIIFFASICAAANRTQRAMLYIALYTIALGAGGIKSNVSGFGSDQFDKSNPKEEKAMVYFFNRFYFCVSLGSLFTVTVLVYIQDHVGRKWGYGISAGTMIIAIVLLLSATMVYRYKKPHGSPLTVIWRVVFLAWKNRRLSYPDHPSFLNGYNSSKVPHTEKFRSNPWIVSTVTQVEEVKMVIKLIPIWSTCILFWTVYSQMNTFTIEQATTMNRKLGGFDVPPGSFSVFLFVSILLFTSINERVVVRVARRITRNPKGLNSLQRIGIGLVFSVAGMVAAAVCEKRRKEMQLNGGTKMSAFWLVPQFFLVGAGEAFAYVGQLEFFITEAPERMKSMSTGLFLTTLAMGYYVSSLLVSLIDVVTHESWLKNDLDQSKLNNFYWLLAVMGVLNFLIFLILSSRHQYKLQHLNGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XMI5</accession>
    <name>A0A103XMI5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ccrd_004430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LEKV01004755">
        <property type="protein sequence ID" value="KVH93513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XMI5"/>
    <dbReference type="STRING" id="59895.A0A103XMI5"/>
    <dbReference type="Gramene" id="KVH93513">
        <property type="protein sequence ID" value="KVH93513"/>
        <property type="gene ID" value="Ccrd_004430"/>
    </dbReference>
    <dbReference type="OMA" id="HIERSIK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14662">
        <property type="entry name" value="STKc_SnRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000132">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000045">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF376">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SRK2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WRKY" evidence="17">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY" evidence="17">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="290"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="584"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KVH93513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="640" mass="73713" checksum="975A689FC21A0B35" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XN71</accession>
    <name>A0A103XN71_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_004147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004599">
        <property type="protein sequence ID" value="KVH93800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XN71"/>
    <dbReference type="STRING" id="59895.A0A103XN71"/>
    <dbReference type="Gramene" id="KVH93800">
        <property type="protein sequence ID" value="KVH93800"/>
        <property type="gene ID" value="Ccrd_004147"/>
    </dbReference>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030029">
        <property type="term" value="P:actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904159">
        <property type="term" value="P:megasporocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009910">
        <property type="term" value="P:negative regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009845">
        <property type="term" value="P:seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000187">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000041">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVH93800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="435" mass="48609" checksum="5FAAFBEDE7A19453" modified="2016-04-13" version="1">MASNVVVVLDNGGGLIKAGIGGERDPTAVVPNCTARPLSSKKFLLADQLLSPTEDLTSAVLRRPFDRGYLINQELQSTIWSHIFSSLLHITPSSSSLLLTEPLFNLPSIQRATDEIVFEEFNFKSLFVSDSPSLVHLYEASRRPYDVVSKAQCSLVVDVGFSFTHAAPVFQNFTVNYGVKRMDLGGKALTNYLKELVSYRSINVMDETFLMDDVKEKLCFVSTDVARDLQIARRRGNDNYFRCTYVLPDGITHTKGFVKDPVEAQRWLTLSEDGELPHLAGTDEADQTEVKSKPSERNKVDLTKNEFSLSNERFLVPEMIFRPADLGMNQAGLAECIVRAVNSCHPHLHPVLYESIILTGGSTSFPGFAKRLENELRPLVPDVYQVKITTQEDPILGVWRGGSLLASSPDFDAMCVTKTEYEELGSSRCRRRFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XQU3</accession>
    <name>A0A103XQU3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAAX amino terminal protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_002721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004395">
        <property type="protein sequence ID" value="KVH95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XQU3"/>
    <dbReference type="STRING" id="59895.A0A103XQU3"/>
    <dbReference type="Gramene" id="KVH95203">
        <property type="protein sequence ID" value="KVH95203"/>
        <property type="gene ID" value="Ccrd_002721"/>
    </dbReference>
    <dbReference type="OMA" id="CGRDEMK"/>
    <dbReference type="OrthoDB" id="1913265at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36736">
        <property type="entry name" value="OS03G0100030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36736:SF1">
        <property type="entry name" value="OS03G0100030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="180"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="361" mass="39286" checksum="9425E6850FA369D5" modified="2016-04-13" version="1">MEFLSISTTPTKCFACCCSRDVVRLPTRLKNRKYVGRKRVASVRALVGGDGRETQSRGGVVGGYRSFGMEVTTFDKSFSADAEFPAGDNIDAVVRLAYGIGIYGIMALAGKLICLAVGIDSSGGCSASFDAIVTGVGYAVPPIMALLFILDDEVVKVSPHARAIRDVEDEELRSFFYGMSPWQFVLIVAAGSVGEELFYRAAIQGALADVFLRGTELVSDARGMAALTGMLPPFVPFAQAFAAVITAALTSSFYYVAASPEDPTYIVAPVLSSACGRDEMKKLFAAWYERRQMKKIYSPLLEGIVALYLGFEWNQTNNILAPIITHGIYSATILGHGLWKIHDHRKKLRQLKLEDKNSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSB1</accession>
    <name>A0A103XSB1_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004366">
        <property type="protein sequence ID" value="KVH95971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSB1"/>
    <dbReference type="STRING" id="59895.A0A103XSB1"/>
    <dbReference type="Gramene" id="KVH95971">
        <property type="protein sequence ID" value="KVH95971"/>
        <property type="gene ID" value="Ccrd_001928"/>
    </dbReference>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH95971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="318" mass="36765" checksum="DF677C6C047CD91B" modified="2016-04-13" version="1">MIMSEIMYLRMEELGLGLVSLLRAAWIAATLPILLACLPLPGLGWFRRALLGFAKRGKILPSNSTKLTVPQRFFSHFYVVAIFWTTILLVAVWFYALKMLPSLIEHDLFSTITSHLTGGSHAFSWHKSLSTREHVYNVWLSVFLLLLMEVQVLRRFYETIYVFNYSSSARMHIFGYLAGLFFYTAAPLSLCCTFAPEVFDFVKNLVAEFIVKGKDRMSKPEFNIWMFGSLREKTETLEEYVIPYGDWFEYVSSPHYSAEIVIYGGLLVASGGADLSLWLLFTFVVANLVFAATETQRWYHHKFDDYPRNRYAIFPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSL3</accession>
    <name>A0A103XSL3_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HVA22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004354">
        <property type="protein sequence ID" value="KVH96113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSL3"/>
    <dbReference type="Gramene" id="KVH96113">
        <property type="protein sequence ID" value="KVH96113"/>
        <property type="gene ID" value="Ccrd_001771"/>
    </dbReference>
    <dbReference type="OMA" id="EHGTHEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF157">
        <property type="entry name" value="HVA22-LIKE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="161" mass="19082" checksum="733A331F65A94114" modified="2016-04-13" version="1">MASQNFFSVVAKNIDVLVGYASIKAIETRSQTDDQQWLTYWVLYSLLTLFELTFSKFLEWFPIWPYAKLFATCWLVLPYFNGAAYVYKHFIRPFYKNPKVQIWYLPRRKGIFGKPDDILTAAEKYIAENGTEEFERLISRADREARSRRGGYTIFDDNYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XSX4</accession>
    <name>A0A103XSX4_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_001638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004338">
        <property type="protein sequence ID" value="KVH96269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XSX4"/>
    <dbReference type="Gramene" id="KVH96269">
        <property type="protein sequence ID" value="KVH96269"/>
        <property type="gene ID" value="Ccrd_001638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH96269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9674" checksum="2D16C70249100817" modified="2016-04-13" version="1">MRLLMPKLSKTYATISRQRATTTIIVVHNYYYEKSFEQDSHKSNVYSYGMMILEMVGGRKNVEVEVYMSLNSKISCLRNVRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XTW3</accession>
    <name>A0A103XTW3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_001148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004210">
        <property type="protein sequence ID" value="KVH96763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XTW3"/>
    <dbReference type="Gramene" id="KVH96763">
        <property type="protein sequence ID" value="KVH96763"/>
        <property type="gene ID" value="Ccrd_001148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVH96763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="41" mass="4766" checksum="865348BFE0C6E8B2" modified="2016-04-13" version="1">MQMFRLVTRVYGFWWHSTLGANCFGYPIIVARGIKGMVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU38</accession>
    <name>A0A103XU38_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-binding EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004080">
        <property type="protein sequence ID" value="KVH96918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU38"/>
    <dbReference type="STRING" id="59895.A0A103XU38"/>
    <dbReference type="Gramene" id="KVH96918">
        <property type="protein sequence ID" value="KVH96918"/>
        <property type="gene ID" value="Ccrd_000989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF5">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH96918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="100" mass="11582" checksum="F6947AB24FF5824D" modified="2016-04-13" version="1">MIEKLGAEGFMNELYKGFESLEDRDTKGFITFESLKRNASWIGLEKMNDDELRCILREGDVDGDGKLSEMEFCVLMFRLSPGLMDGSHRWLESTILMEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XU47</accession>
    <name>A0A103XU47_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 32, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_001042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01004129">
        <property type="protein sequence ID" value="KVH96870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XU47"/>
    <dbReference type="STRING" id="59895.A0A103XU47"/>
    <dbReference type="Gramene" id="KVH96870">
        <property type="protein sequence ID" value="KVH96870"/>
        <property type="gene ID" value="Ccrd_001042"/>
    </dbReference>
    <dbReference type="OMA" id="GMWECAN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH96870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="133" mass="15009" checksum="58933415C73DC940" modified="2016-04-13" version="1">MALDDHPIGADPNGPKYFNGVYHLFYQYNPAGPLFTDQMHWGHSASYDLINWIPLDLAIAPTESFDINNCWSGSATILPGNKPVMFYTGIDSEKCQVQNLAVPKDLFDPYLREWVKYTGNPVINLPQGITKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUC2</accession>
    <name>A0A103XUC2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ccrd_000836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003865">
        <property type="protein sequence ID" value="KVH97073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUC2"/>
    <dbReference type="STRING" id="59895.A0A103XUC2"/>
    <dbReference type="Gramene" id="KVH97073">
        <property type="protein sequence ID" value="KVH97073"/>
        <property type="gene ID" value="Ccrd_000836"/>
    </dbReference>
    <dbReference type="OMA" id="HPADGEF"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF125">
        <property type="entry name" value="OS08G0506700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KVH97073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="356" mass="39405" checksum="3B4BA6C8B375DAEB" modified="2016-04-13" version="1">MYGHGGGGSSDAISRDMNSLLYSSTFKHPADGEFAKIKQLISLDPYPNYDHHDHNQQQQDENHGSNHSSLLRYRSTPSSFFSNLLDDNGDEEFPDPVTASSNHQSKAEESYFTGNQQKKSESDARDFLQFESSSSKPERKESAIQNQDLPPPSTAAMHGGSSRRAPNLPPSNNNSSYGYTNQNNLDSASSFRVMDSTSSNLIRQSSSPDGFLSCLTVDNGFGGMKDARKGSSSSSSLNNHISFSLGPSSSSRFLPQIVENESDSTFGSLKRSRDGEMADVENILHFQQESLVPWKARAKRGFATHPRSIAERVRRTRISERIKRLQELFPNMDKSLNEAQARCKCSSKQLQPGSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XUZ2</accession>
    <name>A0A103XUZ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_000622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003845">
        <property type="protein sequence ID" value="KVH97276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XUZ2"/>
    <dbReference type="STRING" id="59895.A0A103XUZ2"/>
    <dbReference type="Gramene" id="KVH97276">
        <property type="protein sequence ID" value="KVH97276"/>
        <property type="gene ID" value="Ccrd_000622"/>
    </dbReference>
    <dbReference type="OMA" id="RMQTYAI"/>
    <dbReference type="OrthoDB" id="1909968at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04051">
        <property type="entry name" value="C2_SRC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044750">
        <property type="entry name" value="C2_SRC2/BAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246:SF69">
        <property type="entry name" value="CALCIUM-DEPENDENT LIPID-BINDING (CALB DOMAIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246">
        <property type="entry name" value="INGRESSION PROTEIN FIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH97276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="30965" checksum="D720BCEAF5DA43B2" modified="2016-04-13" version="1">MAQTRILEINLISAQGLKIPPSAKMRRMHTYAIAWVHPTAKLRSHLDRVGGENPTWNEKFIFRVSPDFIYGDTSAVQFEIYACGYIRDYLIGNVRYLLSSSTLTSSKTGAVIGTPAFSAVHIRRPSGRVHGVLNIAATVYESSAFAAFTGKSAVCFRDLIGENDNDDKRRRERRLSWNLSRDGSRRSEQSSGAESCDFPIRESTDFSDGNDSTTSSSSSSRTTAAFKDLNGVRSSVKVAGKKELKSDGGGMLCGLMLQRRFSFCPSDQNLLTLAGFHGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XWI8</accession>
    <name>A0A103XWI8_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003806">
        <property type="protein sequence ID" value="KVH98175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XWI8"/>
    <dbReference type="STRING" id="59895.A0A103XWI8"/>
    <dbReference type="Gramene" id="KVH98175">
        <property type="protein sequence ID" value="KVH98175"/>
        <property type="gene ID" value="Ccrd_023561"/>
    </dbReference>
    <dbReference type="OMA" id="RGCCKIS"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="150" mass="16976" checksum="A8204527B7E792DA" modified="2016-04-13" version="1">MSSPSKRREMDVMKLMMSDYVVETPNDRLNEFSVEFHGPKESVFMRAVCGNIVVSNRGCCKISDLLNIFEVFLPQLLLYPNPSDPLNGDAASLMMKDKQQYEEKVKEYCERYAKNNSKSAGEEEESGEEDISDGQYTSSDDDEIPGHADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXB0</accession>
    <name>A0A103XXB0_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ccrd_023247</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="LEKV01003792">
        <property type="protein sequence ID" value="KVH98536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXB0"/>
    <dbReference type="STRING" id="59895.A0A103XXB0"/>
    <dbReference type="Gramene" id="KVH98536">
        <property type="protein sequence ID" value="KVH98536"/>
        <property type="gene ID" value="Ccrd_023247"/>
    </dbReference>
    <dbReference type="OMA" id="PSAMMDT"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="242"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KVH98536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="649" mass="73768" checksum="35B2B156A4C4636A" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XXH2</accession>
    <name>A0A103XXH2_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_023110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003770">
        <property type="protein sequence ID" value="KVH98672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XXH2"/>
    <dbReference type="STRING" id="59895.A0A103XXH2"/>
    <dbReference type="Gramene" id="KVH98672">
        <property type="protein sequence ID" value="KVH98672"/>
        <property type="gene ID" value="Ccrd_023110"/>
    </dbReference>
    <dbReference type="OMA" id="RIGCKAC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF12">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH98672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="236" mass="27411" checksum="AC298E41A811B816" modified="2016-04-13" version="1">MRESPGGTKVWVPKVDSNICPKVGDFFSLVESVENMYRKYGDVAGFDIWLASKKMNSLGGVQTRYFVCSKEGNPPKKEFDSLEVSSGERKRRNTNFKRIGCKACLKVHYVKESARYEVYHFIEGHNHMLCRSDEKMFTRSRRQLDYKDRRNEMNKAAWFCGVVEVVEVGDKMIYNITHKNKNSEVKATYKVVHDVRNESFDCSCNHFVRNGILCHHAFKVMLNSEVQSIPEKYILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYL5</accession>
    <name>A0A103XYL5_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003627">
        <property type="protein sequence ID" value="KVH99268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYL5"/>
    <dbReference type="STRING" id="59895.A0A103XYL5"/>
    <dbReference type="Gramene" id="KVH99268">
        <property type="protein sequence ID" value="KVH99268"/>
        <property type="gene ID" value="Ccrd_022500"/>
    </dbReference>
    <dbReference type="OMA" id="KQMDCEL"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF4">
        <property type="entry name" value="BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0092">Biotin</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="281" mass="29595" checksum="12922E50C9ABC388" modified="2016-04-13" version="1">MASFAIPSPKTSALLAAQPSHKQNFSPKHRNNSVVLFHSDLKSKCALVAGSSSLGFQASKKNQNDGMRVSAQLDEAALQKSDSTPSSEKSVVDSTRETSSEITIPDAASITAFMNQVAGLVQLVDSRDIVELQLKQQDCEVLIRKKEALPTPPAAPMVMTQSPQPLAMLQSQPPPPQATPPSSGPAPSASAPASPTPAKPKSSHPPLKCPMAGTFYRSPAPGVAPFVKVGDKVKKGQVVCIIEAMKLMNEIEADQSGTVVDILAEDGKPVSLDTPLFVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XYQ2</accession>
    <name>A0A103XYQ2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ccrd_022406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003589">
        <property type="protein sequence ID" value="KVH99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XYQ2"/>
    <dbReference type="STRING" id="59895.A0A103XYQ2"/>
    <dbReference type="Gramene" id="KVH99362">
        <property type="protein sequence ID" value="KVH99362"/>
        <property type="gene ID" value="Ccrd_022406"/>
    </dbReference>
    <dbReference type="OMA" id="MIMDIWR"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KVH99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="104" mass="11532" checksum="BAD082DB8F18F590" modified="2016-04-13" version="1">MQPNQSKNSILNPKIANVGTQLPLLFLPNDDAPMAKKLYSCSSSYYDQLHSYVADDLTVGYPSCHKLLNRRLSYVAGSGAEKLTAEDGGFVKGVVTYMIMDIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZE4</accession>
    <name>A0A103XZE4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbohydrate-binding, CenC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ccrd_022109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003425">
        <property type="protein sequence ID" value="KVH99646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZE4"/>
    <dbReference type="STRING" id="59895.A0A103XZE4"/>
    <dbReference type="Gramene" id="KVH99646">
        <property type="protein sequence ID" value="KVH99646"/>
        <property type="gene ID" value="Ccrd_022109"/>
    </dbReference>
    <dbReference type="OMA" id="IFWEVEN"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000104">
        <property type="entry name" value="Endo-1,4-beta-xylanase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000103">
        <property type="entry name" value="Glycosyl hydrolase family 10 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF62">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="509"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KVH99646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="861" mass="95781" checksum="ACFCD581013DCF23" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZN4</accession>
    <name>A0A103XZN4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-heme dioxygenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_021915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003412">
        <property type="protein sequence ID" value="KVH99844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZN4"/>
    <dbReference type="STRING" id="59895.A0A103XZN4"/>
    <dbReference type="Gramene" id="KVH99844">
        <property type="protein sequence ID" value="KVH99844"/>
        <property type="gene ID" value="Ccrd_021915"/>
    </dbReference>
    <dbReference type="OMA" id="TQEEINW"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="198"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVH99844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="343" mass="38052" checksum="400D911550D9237B" modified="2016-04-13" version="1">MSTLSEAYGDYPIPSDITPLDFNSIDKVPETHIWSQPDLQTHQYHPQDPIIPVIDLTDPNAIDQIRQACETLGMFQVINHGVPSVLVNKVESEIRRLFGLPIQEKCKVLRSPTGATGYGTARISPFYDKGMWHEGFTIMGSCLDDAKTLWPHDFQGFCDTMDAFQNQMKLLAHNLLRLIFQSLDATQEEINWATSSHGSQGALQLNSYPSCPNPDGTLGLAAHTDTLLLTLLHQGGGVNGLEIFVEGSGWTPVKPVEDGFVVNLGDLMHIFSNSKFPVVYHRVMVNQSKQRISAAYFCGPPVESVVAPSSKFRNPCFRPLVVKEYISLKAKHFNKALSLIGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103XZY1</accession>
    <name>A0A103XZY1_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ccrd_021837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003405">
        <property type="protein sequence ID" value="KVH99915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103XZY1"/>
    <dbReference type="STRING" id="59895.A0A103XZY1"/>
    <dbReference type="Gramene" id="KVH99915">
        <property type="protein sequence ID" value="KVH99915"/>
        <property type="gene ID" value="Ccrd_021837"/>
    </dbReference>
    <dbReference type="OMA" id="SGWEYRW"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021864">
        <property type="entry name" value="DUF3475"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007700">
        <property type="entry name" value="DUF668"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31371">
        <property type="entry name" value="BNAC09G50660D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31371:SF4">
        <property type="entry name" value="DUF668 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11961">
        <property type="entry name" value="DUF3475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05003">
        <property type="entry name" value="DUF668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3475" evidence="2">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF668" evidence="1">
        <location>
            <begin position="405"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KVH99915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65861" checksum="63012704D7F1F402" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y0C3</accession>
    <name>A0A103Y0C3_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Modifier of rudimentary, Modr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ccrd_021566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003397">
        <property type="protein sequence ID" value="KVI00189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y0C3"/>
    <dbReference type="STRING" id="59895.A0A103Y0C3"/>
    <dbReference type="Gramene" id="KVI00189">
        <property type="protein sequence ID" value="KVI00189"/>
        <property type="gene ID" value="Ccrd_021566"/>
    </dbReference>
    <dbReference type="OMA" id="ECEAMDE"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KVI00189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="206" mass="23343" checksum="F1E2AFF3F613B945" modified="2016-04-13" version="1">MFKFWGSQEQQVDPRPQEITTNSWYPPSVVSSPSSSNPATPNSSNSDTHTQRVGDRSHLSSPVSPTEAAGIIVYLKDKSVDELRKLLSNQEAYQQFLLSIDPVRTQNNVRNELRNETMQLATSAEEKLNDLTKRKAEILKYYSPGSLLHKLQECMDKTDKESEALHEQLLGKEIDLATFVQKYKQLRNVYHKRSLTYLAAKTSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y1J5</accession>
    <name>A0A103Y1J5_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ccrd_020905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01003217">
        <property type="protein sequence ID" value="KVI00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y1J5"/>
    <dbReference type="STRING" id="59895.A0A103Y1J5"/>
    <dbReference type="Gramene" id="KVI00839">
        <property type="protein sequence ID" value="KVI00839"/>
        <property type="gene ID" value="Ccrd_020905"/>
    </dbReference>
    <dbReference type="OMA" id="EYEITCK"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KVI00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="164" mass="18516" checksum="7E886374010A98B6" modified="2016-04-13" version="1">MNERDYQRKKNKFLPKIHSWVQEHGGEPIIPFSCALERNLSDMPQDEAAKYCEDNKVQSALPKIIKTGFSAISLIYFFTAGIDEVKCWQIRRQTKAPQAAGAIHTDFERGFICAEVMKFDDLKDLGSEAAVKAAGKYKQEGKTYVVQDGDIIFFKFNVSVGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3H6</accession>
    <name>A0A103Y3H6_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamine amidotransferase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002678">
        <property type="protein sequence ID" value="KVI01849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3H6"/>
    <dbReference type="STRING" id="59895.A0A103Y3H6"/>
    <dbReference type="Gramene" id="KVI01849">
        <property type="protein sequence ID" value="KVI01849"/>
        <property type="gene ID" value="Ccrd_019871"/>
    </dbReference>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000040">
        <property type="entry name" value="Gamma-glutamyl peptidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF13">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE CLASS-I FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI01849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="270" mass="30660" checksum="59A6D6C506888A81" modified="2016-04-13" version="1">MEELGRMKRFAVLLCAEDSDYVKKKYGGYFGVFVAMLAEEGEIWDVFRVSSGHFPSDDEIGLYDGFVITGSCNDAHGNDAWICKLLILLKKLDSLNKKVLGICFGHQILARALGGKVARATTGWDIGVRSINFSTSMKMFTNLKLPTRLSLIECHRDEVRELPSKVEVLASSDKTKVEMFRYGDHIMGVQGHPEYTKDILLQLIDRLLQHNLIEEWNAIKGRGSMEENEPDRETWKQLCTSFLKGKLWTLRISRGTNTQVRTSIVNPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3M2</accession>
    <name>A0A103Y3M2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family, basic secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ccrd_019831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">2C</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002673">
        <property type="protein sequence ID" value="KVI01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3M2"/>
    <dbReference type="Gramene" id="KVI01897">
        <property type="protein sequence ID" value="KVI01897"/>
        <property type="gene ID" value="Ccrd_019831"/>
    </dbReference>
    <dbReference type="OMA" id="LKWQFTS"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF15">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007119354" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KVI01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="229" mass="25823" checksum="5DD76394C00D2AB1" modified="2016-04-13" version="1">MAPHSFFVYTFLTFSLSFHGIAALEYRVINVAAATPGGIRFNNKIGNPFTKQIMGTINNYIWSAIFQQNDPSDQKQVDSVNTYIVEFDEAAGIAWGNNNINVSSSYINGLVGDLKWQFTSLMLHEMTHVFQWNGEGTTPSGLIEGIADYTVLRANHTQWGFANPGDGDRWDKGYAVTARFLEYCDGITPAFVAKLNKLMRVTYDVKYFEDLTGKPVDQLWQDYKAKYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y3S4</accession>
    <name>A0A103Y3S4_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">4Fe-4S binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ccrd_019732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May donate electrons to ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002669">
        <property type="protein sequence ID" value="KVI01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y3S4"/>
    <dbReference type="STRING" id="59895.A0A103Y3S4"/>
    <dbReference type="Gramene" id="KVI01971">
        <property type="protein sequence ID" value="KVI01971"/>
        <property type="gene ID" value="Ccrd_019732"/>
    </dbReference>
    <dbReference type="OMA" id="WYPDFFR"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KVI01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="225" mass="25783" checksum="E1F5B5ED3EABF11C" modified="2016-04-13" version="1">MAAILARKSISAIRYRQLALAGQVLQGPNTVSGARSFATKHSFSTDKDDEEREKLAREISKDWSSVFERSINTLFLTELVRGLSLTLKYFFEPKVTINYPFEKGPLSPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFATETHEELLYDKEKLLENGDRWETEIAENLRSESLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y4Q2</accession>
    <name>A0A103Y4Q2_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase interacting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_019189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002652">
        <property type="protein sequence ID" value="KVI02470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y4Q2"/>
    <dbReference type="STRING" id="59895.A0A103Y4Q2"/>
    <dbReference type="Gramene" id="KVI02470">
        <property type="protein sequence ID" value="KVI02470"/>
        <property type="gene ID" value="Ccrd_019189"/>
    </dbReference>
    <dbReference type="OMA" id="MAMEHVI"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF8">
        <property type="entry name" value="PAIRED AMPHIPATHIC HELIX PROTEIN SIN3-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="6">
        <location>
            <begin position="459"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="878"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI02470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129443" checksum="8A1F1D3AA7D75907" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y5Z0</accession>
    <name>A0A103Y5Z0_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ccrd_018556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002471">
        <property type="protein sequence ID" value="KVI03149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y5Z0"/>
    <dbReference type="Gramene" id="KVI03149">
        <property type="protein sequence ID" value="KVI03149"/>
        <property type="gene ID" value="Ccrd_018556"/>
    </dbReference>
    <dbReference type="OMA" id="GLAYDEC"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18660">
        <property type="entry name" value="CD1_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
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        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 1-like isoform X1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009463">
        <property type="entry name" value="DUF1087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF28">
        <property type="entry name" value="PROTEIN CHROMATIN REMODELING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01147">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="306"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="613"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="783"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="869"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1453"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1520"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1520"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1668"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KVI03149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="1677" mass="187076" checksum="D099C8BBA770999C" modified="2016-04-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y7X9</accession>
    <name>A0A103Y7X9_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ccrd_017527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002303">
        <property type="protein sequence ID" value="KVI04163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59895.A0A103Y7X9"/>
    <dbReference type="Gramene" id="KVI04163">
        <property type="protein sequence ID" value="KVI04163"/>
        <property type="gene ID" value="Ccrd_017527"/>
    </dbReference>
    <dbReference type="OMA" id="REXEVIH"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="3 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11 13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KVI04163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="97" mass="10739" checksum="C01E300151B6555E" modified="2016-04-13" version="1">MEQEQKSSPPWHGPNRAKYLGPFSGEAPTYLTGEFSGDYGWDTTVLSADPETFAKNREXEVIHCRWAKLGALACVFPEFLTRNGVKFGEAVLFKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y882</accession>
    <name>A0A103Y882_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ccrd_017371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">2C</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="LEKV01002233">
        <property type="protein sequence ID" value="KVI04319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y882"/>
    <dbReference type="STRING" id="59895.A0A103Y882"/>
    <dbReference type="Gramene" id="KVI04319">
        <property type="protein sequence ID" value="KVI04319"/>
        <property type="gene ID" value="Ccrd_017371"/>
    </dbReference>
    <dbReference type="OMA" id="HERKSCC"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KVI04319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="223" mass="24779" checksum="3111D807500AB9FB" modified="2016-04-13" version="1">MANEQEKNLIEILEENNPIDINKYTNYVQSPQCGAIATFYGNTRDTFDGKTVIELRYEAYVPMAIRCLTSICSSARSLWDLNAIAVAHRLGPVSVGETSVFVAVSSVHRVDALDACKFVIDEIKASVPIWKKEVYSNGEVWKENLEFLERRQEVGKDLKRVCCKPKVKVEEEVVAAPLKNGCCRPKVKVDVVAAPVENGCCRPKVKVVEEEEGGCVESCNPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y883</accession>
    <name>A0A103Y883_CYNCS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myc-type, basic helix-loop-helix (BHLH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ccrd_017372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">2C</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LEKV01002233">
        <property type="protein sequence ID" value="KVI04316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y883"/>
    <dbReference type="STRING" id="59895.A0A103Y883"/>
    <dbReference type="Gramene" id="KVI04316">
        <property type="protein sequence ID" value="KVI04316"/>
        <property type="gene ID" value="Ccrd_017372"/>
    </dbReference>
    <dbReference type="OMA" id="CCDYKHE"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000243975">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04873">
        <property type="entry name" value="ACT_UUR-ACR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045847">
        <property type="entry name" value="AIG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844:SF3">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KVI04316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000243975"/>
        </source>
    </evidence>
    <sequence length="278" mass="31490" checksum="CBE1BABA5158BDBE" modified="2016-04-13" version="1">MDFPPNCFKGFTSSEEYALKEMMMMRGGCGRTTSSSSSLVLDSERGEIVRALVRPGTIHHHLHPHSHQHHHQRHHQKGAKAEKALMALRNHSEAERRRRERINGHLSMLRSLIPGTNKMDKASLLAEVISHLKQLRRNATDTTKGVLIPMDIDEVKVEQQDDNSLDGSSYSIKASLCCEYKHEVLSDLKEALDGLHLKTIRAEIATLGSRMMNLFVITGSKDDVNIKDVMSSVRQALKSVLDKFYASQEFSESNTLSNKRRRMSFFTPSNSSSLEDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A103Y944</accession>
    <name>A0A103Y944_CYNCS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ccrd_016888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cynara cardunculus var. scolymus</name>
        <name type="common">Globe artichoke</name>
        <name type="synonym">Cynara scolymus</name>
        <dbReference type="NCBI Taxonomy" id="59895"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>campanulids</taxon>
            <taxon>Asterales</taxon>
            <taxon>Asteraceae</taxon>
            <taxon>Carduoideae</taxon>
            <taxon>Cardueae</taxon>
            <taxon>Carduinae</taxon>
            <taxon>Cynara</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19427" last="19427">
            <title>The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny.</title>
            <authorList>
                <person name="Scaglione D."/>
                <person name="Reyes-Chin-Wo S."/>
                <person name="Acquadro A."/>
                <person name="Froenicke L."/>
                <person name="Portis E."/>
                <person name="Beitel C."/>
                <person name="Tirone M."/>
                <person name="Mauro R."/>
                <person name="Lo Monaco A."/>
                <person name="Mauromicale G."/>
                <person name="Faccioli P."/>
                <person name="Cattivelli L."/>
                <person name="Rieseberg L."/>
                <person name="Michelmore R."/>
                <person name="Lanteri S."/>
            </authorList>
            <dbReference type="PubMed" id="26786968"/>
            <dbReference type="DOI" id="10.1038/srep19427"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">2C</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="LEKV01001910">
        <property type="protein sequence ID" value="KVI04791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A103Y944"/>
    <dbReference type="STRING" id="59895.A0A103Y944"/>
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